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<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K0I746</accession>
    <name>K0I746_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Archaeosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ordered locus">Ngar_c01410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01410"/>
    <dbReference type="EnsemblBacteria" id="AFU57091">
        <property type="protein sequence ID" value="AFU57091"/>
        <property type="gene ID" value="Ngar_c01410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01410"/>
    <dbReference type="HOGENOM" id="CLU_066739_1_0_2"/>
    <dbReference type="OMA" id="IPQTHKM"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="246" mass="27579" checksum="CE3DAD836A531201" modified="2012-11-28" version="1">MQQKVAASARVKLSEIFTSIEGEGILFGTKTMFVRLSGCPLKCHWCDTPYALPLDSGSDYSIDEAKELILKNLHPNTYKVNFTGGEPLVQHEAVIELAKFVRQKGLRTFLESACYDAARFAKVLPYIDLVKVEFKLKDSKVVDEKHYGSLLMSELDCLKLAVGSGGKTTYIKVVVTNSSSLKEFKELVREVFSVARPTEIAGFIIQPSYKIDEPTLDVLFGFYDAVYPLYDQVRVVPQLHKIIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7L8</accession>
    <name>K0I7L8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02980"/>
    <dbReference type="EnsemblBacteria" id="AFU57246">
        <property type="protein sequence ID" value="AFU57246"/>
        <property type="gene ID" value="Ngar_c02980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02980"/>
    <dbReference type="HOGENOM" id="CLU_2875197_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-298-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7241" checksum="E60144EAD15E225D" modified="2012-11-28" version="1">MIPQNITKEHILKAMQEIDKNGVPEERLSTKYYLQYNGKNYPPKYTISLANKYANGRAGPIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7Q5</accession>
    <name>K0I7Q5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c03380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57286">
        <property type="protein sequence ID" value="AFU57286"/>
        <property type="gene ID" value="Ngar_c03380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03380"/>
    <dbReference type="HOGENOM" id="CLU_1088267_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-338-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="22878" checksum="0354F6D22742690A" modified="2012-11-28" version="1">MSAIPYALLKDSVAIKIKSLAEHAPADGEKIFFAFPRQDLSPSVVTADIFFASIYSDGSWSIRPLGVYQRPGVTAPPEAWWGGMDFVIDHGTTRCPDCLSRSWVATGYPLKQPYQFYKITSQEPTPSQTTTTSTTPSQSQNQGTTPTEAISQPTIPGVTPTPTPTPTPTPSQTTTTSTTPKQWYEDVTTLIVLAVVAMISIAVVIVVRQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8I2</accession>
    <name>K0I8I2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06430"/>
    <dbReference type="EnsemblBacteria" id="AFU57586">
        <property type="protein sequence ID" value="AFU57586"/>
        <property type="gene ID" value="Ngar_c06430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06430"/>
    <dbReference type="HOGENOM" id="CLU_046006_11_2_2"/>
    <dbReference type="OMA" id="YKQAFGA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-641-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17406" checksum="82BA552B742C26CA" modified="2012-11-28" version="1">MAKVNPIPKGYHTLTPGLAVRNADQAIEFYKKAFGAKEKGRMPGPDGKIMHAELQIGDSRIMLGEENPQMNPSPQSLNGSPVGLYIYVRDADKAFNQAVKAGATMTMPIMDMFWGDRAGMVTDPFGHKWWVASRKRNLSPKGLKKAAEEWFAQQAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I973</accession>
    <name>K0I973_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57876">
        <property type="protein sequence ID" value="AFU57876"/>
        <property type="gene ID" value="Ngar_c09340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09340"/>
    <dbReference type="HOGENOM" id="CLU_2857202_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-932-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8387" checksum="9208C6E57805F4C7" modified="2012-11-28" version="1">MLHWIWVKKNIQAVLKRDDGRIVREAKLKKQADQILQFLKGTDAAVVMESGYNYQFLYDLLKERRTMMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I976</accession>
    <name>K0I976_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57881">
        <property type="protein sequence ID" value="AFU57881"/>
        <property type="gene ID" value="Ngar_c09390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09390"/>
    <dbReference type="HOGENOM" id="CLU_1665552_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-937-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="17404" checksum="A7937DB095C72CD4" modified="2012-11-28" version="1">MTAAAVKNPLSRKRHFILTPALFCTSCSRYLITSAMDSSALTTCFRARVNLLPYNSITYVLAYMKKWVVPLSAAPRLTSPSFSGWLAMVGTLVMSKAMSAAFEPRTSMTRSCCCSTLLTAALTREMSILARWYYTSSRDGMRAKEPHVSVIDVAPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9Z5</accession>
    <name>K0I9Z5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nuoB2</name>
        <name evidence="3" type="ordered locus">Ngar_c12060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12060"/>
    <dbReference type="EnsemblBacteria" id="AFU58146">
        <property type="protein sequence ID" value="AFU58146"/>
        <property type="gene ID" value="Ngar_c12060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1152"/>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="GPYWEHG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="16669" checksum="CEDA170EF7FE1D2D" modified="2012-11-28" version="1">MVRALDRPLGYAINWSRVWSLWPVHLETGCCSVELGAASGPRFDAERFGILEAFGSLRQCDLLIVLGTVNRKMAPRLRLVYDQMPEPKYVVAMGACSITGGLYFDSYNVLPGVDSVVPVDIYVPGCPPRPETLIQGIMLLQEKIKRSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC85</accession>
    <name>K0IC85_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58976">
        <property type="protein sequence ID" value="AFU58976"/>
        <property type="gene ID" value="Ngar_c20440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20440"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_2"/>
    <dbReference type="OMA" id="HEIVKFA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2042-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="16403" checksum="449F0991BCB73A33" modified="2012-11-28" version="1">MAKPILVPHDGTEMSDRALDKAIEFARVLKSEIIIVHIVDSRFVPPSATLGLISEKTTLENAKTQLIRILKTGAEIMLKDRIQKAREGGVSARFLLGVGSPAEEIVSIANAEKAEMIIIGSRQLKATKMITLGSIARRVSETASCPVMIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICX0</accession>
    <name>K0ICX0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59206">
        <property type="protein sequence ID" value="AFU59206"/>
        <property type="gene ID" value="Ngar_c22760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22760"/>
    <dbReference type="HOGENOM" id="CLU_2875209_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2274-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7482" checksum="BACB51216AA89953" modified="2012-11-28" version="1">MKAQPRQQKQSSVKPRKDYDYNKPIGKCVVCYTLSGWHCYDCNNDFCQMHFHDHKQKNLCKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID26</accession>
    <name>K0ID26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nickel/cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06220"/>
    <dbReference type="EnsemblBacteria" id="AFU57565">
        <property type="protein sequence ID" value="AFU57565"/>
        <property type="gene ID" value="Ngar_c06220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06220"/>
    <dbReference type="HOGENOM" id="CLU_059308_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-620-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="25476" checksum="C0403D7E487487E3" modified="2012-11-28" version="1">MQQDPVLLGIIAFGLLHGLNPSHGWTVAVLYSIRSKAPLRSSIISSGIIAGAHFFSSIVVVVAFILVTTFVEVPQLYLNYVVAAALAVLAYIFWKEKGTDVVESQHGHLHHDIMGHTEHKHLHWHEDTGNHVHLHVHEKIFVPTLAAMAGLALALGFAHEEEFVILTLAVGGVNPLFLMLAYATAVSASLIGTTVLAVKIYARIERRVIRYAKYLPKVSAVILAAMAAGFALGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID76</accession>
    <name>K0ID76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC uptake transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mntA</name>
        <name evidence="3" type="ordered locus">Ngar_c06720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06720"/>
    <dbReference type="EnsemblBacteria" id="AFU57615">
        <property type="protein sequence ID" value="AFU57615"/>
        <property type="gene ID" value="Ngar_c06720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06720"/>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_2"/>
    <dbReference type="OMA" id="DPHIWFD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="323" mass="35285" checksum="372CA2ABF3A24190" modified="2012-11-28" version="1">MYAAGGGNNNSDNTISSSVAEDNVSSRKLNVVTSVAPITNIVRNVGGDRIELTGIVPEGVNSHTFELTPSDAVVVRGADLVIINGLHLEVDFERVVDAAGNPNLQLLKLADNTITSDQWVFDFSFPEEEGDPNPHLWLNVQHAMKYAELVRDKLIEMDPANSDYYSSNAKKYLALLEELDQGIMQSVQTVPPDNRKLVTYHDSWAYFAPRYGMTVIGAVQPSDFGEPTPQEVARIIEQIRAEGVPAIFASEVFPSKVVDQIAREANVQIVETLRDDDLPGEPGDPENTYVGMMVANMNTMLTSLGGNTDALEGIDPSNTYTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID87</accession>
    <name>K0ID87_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57625">
        <property type="protein sequence ID" value="AFU57625"/>
        <property type="gene ID" value="Ngar_c06820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06820"/>
    <dbReference type="HOGENOM" id="CLU_120323_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-680-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="195" mass="22397" checksum="A53DFB7E683BAB85" modified="2012-11-28" version="1">MGDKDGMNVFLGHGVHKKIQFWSDAQGKEFAVRLSNEPDFRAVSNPSVKYIKLVEEADYFSDMNYDWKFLLEYWMGVKNGKIEPFGLNGKEEPNHITLDLIDTQTASVKADKKRIKRDRARPLLKCRYCMLSYNSEKERQEHELAWHAEKMKKDSSGQANNKLLLKSSSSNNNNSLKFSSDANDDPGRNKMRGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDF1</accession>
    <name>K0IDF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24980"/>
    <dbReference type="EnsemblBacteria" id="AFU59421">
        <property type="protein sequence ID" value="AFU59421"/>
        <property type="gene ID" value="Ngar_c24980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24980"/>
    <dbReference type="HOGENOM" id="CLU_140794_0_0_2"/>
    <dbReference type="OMA" id="WMLSLWY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2497-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="154" mass="17587" checksum="C5FF0396047150D5" modified="2012-11-28" version="1">MKIINAMPGIGAMTKDEVDRFLESKLNIQLATIDEMGDPNIQPLWFYYDKGDNKLYVMTRKTTKKVQNVRNNPNVYFSIDDENFPYKGVKGKGTATISGDTSKVMPIVEKIHLKYLGTLDHPIAKGNIEAARSRHEVLIEIDPRFFSTWDFGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDW3</accession>
    <name>K0IDW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57935">
        <property type="protein sequence ID" value="AFU57935"/>
        <property type="gene ID" value="Ngar_c09930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09930"/>
    <dbReference type="HOGENOM" id="CLU_2629847_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-991-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8548" checksum="FD6F9FC352FCA56A" modified="2012-11-28" version="1">MVEESFVRILTVVALFSVGTVSAITTATKESRIAAAPATVHRYGTLAETKWHEVMIDDYYRIESALLHVKENGFAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEB0</accession>
    <name>K0IEB0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01940"/>
    <dbReference type="EnsemblBacteria" id="AFU57143">
        <property type="protein sequence ID" value="AFU57143"/>
        <property type="gene ID" value="Ngar_c01940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.194"/>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_2"/>
    <dbReference type="OMA" id="EILCKHE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-194-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="419" mass="44540" checksum="DFEB5FE4C82A1B1D" modified="2012-11-28" version="1">MAAKVAVVDCQVAGIAGDMLMASLVDAGANKAKVIDAIFACQDSLKGSKISKVDFAKVVSHGFTATQLQMKYSDSVHERKGAEMHRSLARCCDSLGLDQKAKTFALESLKTIISTEARIHGEDFASIHLHEASSIDTLADLVGCAVALQDLGLFDGSRIYSTKVAVGGGLLKFSHGTVPNPASAILEIFKNRQFVLVGGPVEDELTTPTGAAMLVNLASGSINYYPNIAPEKIGYGVGTKKFDGFANVVRVLVGTSGVGVTEIAKDTVCVVETNIDDVSGELVGNLVEKLSEIAKDVTVIPGTTKKSRPTYLIRIISENAELNNVLDVLFSESGTLGARVQEVERYVLPRAVLIVPVDISGSTFNVHVKVVKDRAGRITNAKPEFEDVRVIASRCHMPVKRAMELVNAQVAKRIGGGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEU8</accession>
    <name>K0IEU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59881">
        <property type="protein sequence ID" value="AFU59881"/>
        <property type="gene ID" value="Ngar_c29630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29630"/>
    <dbReference type="HOGENOM" id="CLU_2662489_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2963-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8344" checksum="452E5B86B5003D20" modified="2012-11-28" version="1">MKTLDKSLPKLFEAVASGEHIREVKFSGTTDTTNKKTRGDYFIITLTDVIVTRTSRADQVETADPRKASASTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEU9</accession>
    <name>K0IEU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58290">
        <property type="protein sequence ID" value="AFU58290"/>
        <property type="gene ID" value="Ngar_c13520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13520"/>
    <dbReference type="HOGENOM" id="CLU_2490568_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1350-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="10016" checksum="2DFE84F5F4BE350B" modified="2012-11-28" version="1">MVDSRIKTIPDTVRFYRLLKRDPSLMLKEEGDFVFGYTWGLMIAGVASVFRDVQRQINEKEMDEAVQVLNSRMHQIRQAILNASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF48</accession>
    <name>K0IF48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57433">
        <property type="protein sequence ID" value="AFU57433"/>
        <property type="gene ID" value="Ngar_c04890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04890"/>
    <dbReference type="HOGENOM" id="CLU_119855_0_0_2"/>
    <dbReference type="OMA" id="HIVALMM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-487-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="14955" checksum="DDC20C2A30D2AA20" modified="2012-11-28" version="1">MDRPTGVTIIAVLMAIAGIVMIIAGISALAFAPFIPIAVPSQDLPAGLSMTMLGGIAVASGAFMLALGIAGLVISYGLFKGNGWAWTAAVVLSIIGIATSVLAIVTGNFGSVISLIINGVILYYLYRPHVKAYFGKAVSAPASDTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA7</accession>
    <name>K0IFA7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60056">
        <property type="protein sequence ID" value="AFU60056"/>
        <property type="gene ID" value="Ngar_c31400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31400"/>
    <dbReference type="HOGENOM" id="CLU_1709193_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3140-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="153" mass="17039" checksum="3319CB71FFD29C63" modified="2012-11-28" version="1">MAKVTKAQTAQEYRVQKVTAKVIMEVVEGCSHSGLSVKDAAEYVGVSVEYARRAVDIATQFGMPVESSGTYSLAPDVENVAKADEEQKRIIFRKYLQRYEPIIIFISLLSKGNNPEVAARKVGVIYAINNGKDNIENMFLEWGRYAGIIEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA9</accession>
    <name>K0IFA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c15560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15560"/>
    <dbReference type="EnsemblBacteria" id="AFU58490">
        <property type="protein sequence ID" value="AFU58490"/>
        <property type="gene ID" value="Ngar_c15560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1525"/>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OMA" id="TRSVECE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1554-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="258"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="486"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="700" mass="77136" checksum="9B97C8DCCA9ACF84" modified="2012-11-28" version="1">MGELEKNEKVGEIIAQEQAAPQKRGRPAADIDSSVTKVTTESEEAVGKIILKSIPPDSQITLVRFEGPNIALYTKNAKFALTELTYYLSSLSKTLKKRFIIRTDPSVRLPEDQTRQAVVKLLPRDVLVSAVFCDDATGEVVLEVSKPEAIDPNMIVQIAQSTGWIAHTRRSPHIPSTSINTIHSTLKGSAKERTDFMQKLGKRIFRGSLVVGNGNGNGSAHYQQQAAVSEPGSAKPQSWSTSKEEVMLFCLGGVKQVGRSCFIVVTPESKVMLDCGINPGEMSGLNAYPRLDWFNFDLDDLDAVIIGHAHIDHQGFLPALFKYGYKGPVYCTEPTLPLMTLLQMDSVKIANSNGTYLPYEARDVNEVIKHCITLPYGKPTDISPDITITLQNAGHIMGSATVHLNISGAHNILYSGDYKYARTQLLDSAVSMYPRVETLITESTYGNTTDVMPDQQVVYRSFTESINKTLIEGGKVLIPVPAVGRAQEIMLVMAKEMREGRLVESPIYIEGMISEASAIHMSYAHYLGSEVRKSVSQGINPFQSEYFTVISGHGKRDDVLNDENPAIVMATSGMLEGGPSVEYFKELAPNPKNKIMFVSYQINGTLGRRVLDGAMSEVSMMDKTGKVKVVPVRCQTQKIDGFSGHSDFNQILNFVSRVKPKRVLVNHGERSKSENVASAIYSRLKIRSGVPDNREIVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFN5</accession>
    <name>K0IFN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PUA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16920"/>
    <dbReference type="EnsemblBacteria" id="AFU58625">
        <property type="protein sequence ID" value="AFU58625"/>
        <property type="gene ID" value="Ngar_c16920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1669"/>
    <dbReference type="HOGENOM" id="CLU_090468_1_1_2"/>
    <dbReference type="OMA" id="CREHREI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1690-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022430">
        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03684">
        <property type="entry name" value="arCOG00985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="89"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="19053" checksum="F8E78B6DBB10389D" modified="2012-11-28" version="1">MERINTIARIIALISLKTFVLSKSETGELLDKLGSVWPQGVVPKVKSIKIYEVEEGRRLLIADETVAVQVQDSIVPFLGSKPEVLQRFPSVTVDMGAVKFVCNGAKVMRPGITNFDSFKKGDIVVVKDQTHGKALAVGVALEDSESAKAMAKGYVVENLHYISDKMWEAYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFP2</accession>
    <name>K0IFP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCM family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17020"/>
    <dbReference type="EnsemblBacteria" id="AFU58635">
        <property type="protein sequence ID" value="AFU58635"/>
        <property type="gene ID" value="Ngar_c17020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17020"/>
    <dbReference type="HOGENOM" id="CLU_421900_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1700-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="1">
        <location>
            <begin position="238"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="649" mass="72561" checksum="0565119B515C6982" modified="2012-11-28" version="1">MTGKEARLPDSMIPEDARAVKSLDNLLDIETPGLSGQEVQVPATIASNSISYTIPVIMKVKCLNHDDKHTCEKEASFAVDLKDYPKFTEVSDFVRERILINLFKNSENTGFNHKCSLVVKDPQTTTIKRIRARPVVKNLLSKDGKFYDSMGREWKSIDIFVLQNGLATQPGKHIELTGLVLPDPRSSRITMMARHVNEAQEASADIEEMNRLAKLFENWTVEQRMDWIIKNVATYAKVVKRENVIHGALLCFFSPLYLNFNGEKIKGWMKIVIIGDSTAGKSKTVRTVINELFGLGQIISGEMASMAGLAAANMQASSGQWMIEYGPFVLMDAKLLAVDGAHKVSASDWAAIGEAERDGILRVTKAGKAEANARTRLILIYNPVTEDRRFTRAMDTFRRGAQAIETVMDATSIARTDLAIFVNASDVTPEDIHIVHKGTTDPELQCLTSLCRHVWTGKYETIFEDKALEKILSEATRIQKKYYLTRIPLASPDIDKKLARLSASLAALTCSFSSDWSTLTVKQEHVDYVVNLLESEYENAGLGSLAMDDRQEVTPDEAATLIQNMQTALGQKALDDKVIHEMINWISGKEKFTREDMMHKFRLSDKEQLRPLVHQMKEDGLLKQGNRGFTATLKLTKLSKVIGDKNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFV3</accession>
    <name>K0IFV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57688">
        <property type="protein sequence ID" value="AFU57688"/>
        <property type="gene ID" value="Ngar_c07450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07450"/>
    <dbReference type="HOGENOM" id="CLU_2165143_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-743-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12319" checksum="2D22A852B85CCFAD" modified="2012-11-28" version="1">MYKPKSTRDIYMESLSVNSASIERQLADQSVLAGEIKSFLDAVSKLYQENVDRIVEECDKDMMALERVPSPLKLFVDCLAQVEKSANLSPQARALVQRYASAWEDWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFW6</accession>
    <name>K0IFW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33710"/>
    <dbReference type="EnsemblBacteria" id="AFU60286">
        <property type="protein sequence ID" value="AFU60286"/>
        <property type="gene ID" value="Ngar_c33710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33710"/>
    <dbReference type="HOGENOM" id="CLU_037990_2_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3371-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="21636" checksum="353BC545137876B5" modified="2012-11-28" version="1">MLAIARERAKENGLANIIEFHEADAESLHLPPSSIDAIVCRFGLMFMPSSWYFESNESCPCPGGRIAAAVWSAPDKVPSFVVPLQIVMKEMATPPPPPESPGPFSLADTKLLRQKFEQAGFHDINIEAILSDFKLPSPKEFVDFVRSTAGSLGAMMAGLPAARQDEICNKVADAVRKHADPRIGTVSFTNDVILVSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG86</accession>
    <name>K0IG86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c18730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18730"/>
    <dbReference type="EnsemblBacteria" id="AFU58805">
        <property type="protein sequence ID" value="AFU58805"/>
        <property type="gene ID" value="Ngar_c18730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18730"/>
    <dbReference type="HOGENOM" id="CLU_042632_1_0_2"/>
    <dbReference type="OMA" id="EPHSHWH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1871-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="162"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="299" mass="31438" checksum="A8E0D9E2D28CAD02" modified="2012-11-28" version="1">MAAEKAEGHRQYAVAGYLSVLLASALFGSVFTLAKVPLATMDPLALSAIIYTIAGLGLLPFAKASFRLATRREYYYLAIVTIFGAVAAPVLLLYGLQQTNAADAAILANGEIVFTILLSAMFFGEKPHGRVGLFAVILVVIGLFIATTDLKVSETILEFNAGNLMILVSMLMWAIDNNISRRLTSNVSPAKIAMVKSLSGGLVLLAIALALGKSDSIASIEPSLWLIIAGMSVSGFGGALLLFLQGIKRIGTVKTMSVFSMTPIFGIVIAAIALGESISVFQGIATGLIIMGILLVSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG89</accession>
    <name>K0IG89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="5">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c18780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18780"/>
    <dbReference type="EnsemblBacteria" id="AFU58810">
        <property type="protein sequence ID" value="AFU58810"/>
        <property type="gene ID" value="Ngar_c18780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1861"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="LHMSIIG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1876-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="217"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="490"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="728" mass="80961" checksum="54ECE11C22493592" modified="2012-11-28" version="1">MRTGSDESSPIQLRVAEAKHRDVGKRRARIDARYMDHLGIQAGEVVELVGKRSTAVTAWPADEEEKESDIIRIDGQTRKNAGVGLNDLLNVRKIDCKQAKSVTLMPLGDSTITVDKEFCDFVKNRIKGYPVNEGDEISVVILGNQMDFKVERVSPKAIARIERQTKLTIMAEITSDRKPRVTYEEIGGMKEQIKRLREIVELPMRHPEVFARLGIEPHSGILMYGSPGCGKTLIAKALASESEANFFIINGPEIMNKYYGETEARLRDIFKEARESSPSIIFIDEIDAIAPKREEAFGDVEKRVVAQLLALMDGMSERGQVIVLGATNRPESLDPALRRPGRFDREIEIGVPNAEGRLEILQIHTRGMPLSDDINLQELASELHGYTGADIKALCREAAMKALRRYLPEIDLEGDKISPEILEGMVITNRDFKEGMKEIVPTAMREFYVEVARIKWNDVGGLYEAKRTLHDNLITAIREPDKFAKMGIRPPRGALLYGPPGTGKTLLAKALATESNANIIVVRGPEVLSKWVGESEKAIREIFRKAKSSSPCIVVFDELDSLARPRGQEEDMSGNERVLSQILTEMDDSGSAGVVVIGITNRPDLIDTSLLRPGRLDLILYVGPPDEKARQEILRIITQPMPLANDVDLAGIAQSTKSFSGADLVALCREAAVNAMQSKSEIISNADFAKAIRLVRPSITKDVEDWYESIKKNITYAMPKQIDKTFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGC9</accession>
    <name>K0IGC9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58855">
        <property type="protein sequence ID" value="AFU58855"/>
        <property type="gene ID" value="Ngar_c19230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19230"/>
    <dbReference type="HOGENOM" id="CLU_2433964_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1921-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10123" checksum="780825D1A4B8F8E4" modified="2012-11-28" version="1">MAFGRTASYFFSRLLSHAVVSKKSGICIIADMGAFFLINRVTEMGLGRRMKVKGFCTYHQRDFDMLSECQKTTIFGEGYKVPLVVVQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGE5</accession>
    <name>K0IGE5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57903">
        <property type="protein sequence ID" value="AFU57903"/>
        <property type="gene ID" value="Ngar_c09610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09610"/>
    <dbReference type="HOGENOM" id="CLU_3163251_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-959-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="47" mass="5929" checksum="8ADAA565B8C4FED6" modified="2012-11-28" version="1">MLEKRIKVLIEGHYRERNCLRLVKRLKREKGMLFFTFLKEKKRSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM1</accession>
    <name>K0IGM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57978">
        <property type="protein sequence ID" value="AFU57978"/>
        <property type="gene ID" value="Ngar_c10360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10360"/>
    <dbReference type="HOGENOM" id="CLU_1269965_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1034-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="25463" checksum="DCA87A8C9D672C50" modified="2012-11-28" version="1">MSSQLKVMPETIVSYGVPIEMSKRKEIAVEYWQNFLAWFNTAYPQMQRTNTINAYRSFLAAHNINFAHGEGKRYGLSTTLERLGEYKDIMLTPDQIDKINKRLENGNDWESWSFMNIDLHTGARAFAMASMSRDRIAFSPLFRVEQFESKIKRGEWYLTREGKWWVKYPTEECKAVVETAYDRLPKDRKFLFFKDAKSDKANCLQAGYKVQKDIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGP9</accession>
    <name>K0IGP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20740"/>
    <dbReference type="EnsemblBacteria" id="AFU59005">
        <property type="protein sequence ID" value="AFU59005"/>
        <property type="gene ID" value="Ngar_c20740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20740"/>
    <dbReference type="HOGENOM" id="CLU_139738_0_0_2"/>
    <dbReference type="OMA" id="RYWYHAW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2072-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="13732" checksum="BD927003EFDCF98C" modified="2012-11-28" version="1">MSADNNRLEELAKHKYINLETYRKNGQPVSTPVWFMIDNGLVYVVTSADTGKAKRLRNNPAVRIMPSGFRGEPKGEWIEGKARFAEGAEAERAIQLRKKKYGLQARLAGMIRGASTVIAIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGT0</accession>
    <name>K0IGT0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mvk</name>
        <name evidence="12" type="ordered locus">Ngar_c11110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11110"/>
    <dbReference type="EnsemblBacteria" id="AFU58053">
        <property type="protein sequence ID" value="AFU58053"/>
        <property type="gene ID" value="Ngar_c11110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1053"/>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_2"/>
    <dbReference type="OMA" id="NTVCTYG"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="101"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU58053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="326" mass="34138" checksum="C0C038E5EDED5880" modified="2012-11-28" version="1">MTKGGRASAPAKVILFGEHFVVYGNPAILASINRRITVDARTIDKEDKIVIRSDIGLAGEYSSSGFKAIEGGTEARSALDPLHSAITQVLVARGKRTGIKVAISSDVPPGIGLGSSAAACVATVAAVNSLFQKKPSRHKICEMAIESERLIHKNSSGADCYISTFGGLIHYSSKAKGFKEIRSKGGLALVVASTGVRHSTGDLVAGVMRFKERNESLFQNLAKQAADICTQAQSAMVSGRRDKLGTLMNENQAILRQIGVSHYKVDDLIDICGKAGALGAKITGAGGGGAVIALAATKQDSARIAARARAAGYESFEVEIDRKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH75</accession>
    <name>K0IH75_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12580"/>
    <dbReference type="EnsemblBacteria" id="AFU58198">
        <property type="protein sequence ID" value="AFU58198"/>
        <property type="gene ID" value="Ngar_c12580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12580"/>
    <dbReference type="HOGENOM" id="CLU_1615361_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1256-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="36"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="18761" checksum="07F3CDFCDF11478D" modified="2012-11-28" version="1">MLGKRHPNRISVTKNFRQHIANMAGSRVLPADARVRVLGISAANMNDDVAPWTSTSEAALEFALDYAKNKHNTDTIMLDLRQLNFRHCEGYYSKNAKACIFLCSISEMDEKDQMIEIYDRAIVWTDVVIVATLIRWESTSSLYYQMAQRMNCVQNQIVTHNTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA9</accession>
    <name>K0IHA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58268">
        <property type="protein sequence ID" value="AFU58268"/>
        <property type="gene ID" value="Ngar_c13300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13300"/>
    <dbReference type="HOGENOM" id="CLU_3075476_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1328-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5889" checksum="8259C9E84A5257E4" modified="2012-11-28" version="1">MLPAGIAGVTVEKLDRIYFCTECKTVFLFKLDASDHKKESGHTQLREMPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHL1</accession>
    <name>K0IHL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N6 adenine-specific DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25170"/>
    <dbReference type="EnsemblBacteria" id="AFU59440">
        <property type="protein sequence ID" value="AFU59440"/>
        <property type="gene ID" value="Ngar_c25170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25170"/>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_2"/>
    <dbReference type="OMA" id="FIDINPV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2516-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="18335" checksum="2BD8C20D1B130BA8" modified="2012-11-28" version="1">MYVPSDDTFLLADCIREYSGKWALEIGVGSGVLLNLLEKSFANVAGSDIDLRALEHCRGRSGAMLVCCDAASAFAGRFDLIVSNPPYLPDDKVRDTTVHGGPAGVETTMHFIQSALPLLARGGKMLFVVSSLADSTALDRLIKEKKMHKKAVKEKKLFYETLTVVELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT5</accession>
    <name>K0IHT5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59505">
        <property type="protein sequence ID" value="AFU59505"/>
        <property type="gene ID" value="Ngar_c25830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25830"/>
    <dbReference type="HOGENOM" id="CLU_2857214_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2583-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7587" checksum="C91856F84B508082" modified="2012-11-28" version="1">MERQELKIQKAWQRLDARAARKLPKREVEFYSEIGKKGGEARAEDKESLREAGRNRRTEIRSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ5</accession>
    <name>K0IHZ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chaperonin Hsp60/Cpn60/TCP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thsB</name>
        <name evidence="5" type="ordered locus">Ngar_c06140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06140"/>
    <dbReference type="EnsemblBacteria" id="AFU57557">
        <property type="protein sequence ID" value="AFU57557"/>
        <property type="gene ID" value="Ngar_c06140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.590"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="HILITDR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="518" mass="56705" checksum="5AF6AD5D36F4461F" modified="2012-11-28" version="1">MSNPNFGVWRPVAENVELNALESNSNAVMAVADTVRTTLGPKGLDKLLIDQAMNRHVSNDGVTILLSLKAIHPVARMIVEIAERQEQLVGDGTTTAVVMSAEMIKEGKRLVKELGVHPTKVVEGIDSGVRHACQLLESEAKRISINDVELEQIVRTSLASKLDGKRLAELVISALRTVGENARYNGQYDFNKSIMVIRKTSMEDQIINGVVLERKKLDPELPMEIHNAKVMITKLDLKPVKESWIKENNKYQEILLMENDRIKKSKEMVDAMLATGANVILIASPEVDQAVEDMLVAKRVFAARIATEEIEHLSRYTGAKPVRVMEDLSRPDILGTAERVREDEDNNMIYLEGGSGRNMVTIVVSGTTKETSLERWRAAIDGVNAAEAALNKGVVPGGGAAELHVVEKVKSLRLKGLEQVGLEVVTSALESIMRQILTNAGFNGLEKVMAAKASPPGFGIDINSGEPVDMWKMGVIDPLMVKTMALQAAGEIAKSVLRIDRNLAAEDLSQQALSETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ6</accession>
    <name>K0IHZ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26330"/>
    <dbReference type="EnsemblBacteria" id="AFU59555">
        <property type="protein sequence ID" value="AFU59555"/>
        <property type="gene ID" value="Ngar_c26330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2607"/>
    <dbReference type="HOGENOM" id="CLU_026821_3_2_2"/>
    <dbReference type="OMA" id="MENSAFT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2633-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="422" mass="47631" checksum="CAFDCBF474543173" modified="2012-11-28" version="1">MEFAGEITDPVHRSIRFSEVEKEVIDSPAFQRLRRIRQLAGAHLIYPSAQHSRFEHSLGAMHIAGLAGETLLGKGYIDHAEAVQDLRLAALLHDIGHGPFSHLFEEVLEYRCNTTHEEMGRRIITQTEIADILDRHGHSADQICQLSFGQPKVNFMNEIISGGLSADIMDYLPRDGLFTGAEYAKVDYHRLTSSLEVSRNRLAINRSALNSLESMLISRYEMFKAVYFHKTVRSAEVMLLHSMIAADEALGLTDTSLDNYLGLTDEATLERLCALDSSGKYAFAGKMARDYRDRRLLKSVYEKFLHKRDKQKMDRKALQATAARIADAAGVDRNHVFVDASRAHSMPLTPSKEEMYSVLVVDKDRVYEMPVSEIPLVESISGFFDMLRVYTTAENRQKVERSVKKVLGEQETLYMGAGKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II86</accession>
    <name>K0II86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57687">
        <property type="protein sequence ID" value="AFU57687"/>
        <property type="gene ID" value="Ngar_c07440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07440"/>
    <dbReference type="HOGENOM" id="CLU_1307858_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-742-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="210" mass="22821" checksum="E3105D677BC0C527" modified="2012-11-28" version="1">MAGGRFADEKADMHPRSWLSRYRRTSIGYLTKMLLFYHGIGIGLLLVGSAIIEQALPDHEEPSIPRSLSGVLAAGPLEETTFFGIPFYIFGNAYSVLVTGAVWVAMHLLNTDTLSVNSLAFGNLLFVLPSLFFSLRTWVSGKGWFSVVTHSAWNGIFFAAGCSAGEFTCTAIDSDANTTVISIGLSAALIGATYVLYKRKEGKERQRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0II96</accession>
    <name>K0II96_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rps3p</name>
        <name evidence="6" type="synonym">rps3</name>
        <name evidence="10" type="ordered locus">Ngar_c17350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17350"/>
    <dbReference type="EnsemblBacteria" id="AFU58668">
        <property type="protein sequence ID" value="AFU58668"/>
        <property type="gene ID" value="Ngar_c17350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17350"/>
    <dbReference type="HOGENOM" id="CLU_058591_1_1_2"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="23492" checksum="08A8042E7AAF01FB" modified="2012-11-28" version="1">MELNEFLADALKDAGYGGVEVQKTPVGARITIYVTRPGLVIGRKGTGIKDLMTKIEQKFGLQNPQISVLEVTNPELNPHIMCNRIAQLIERGTAFRRAAMWSLNTIMNAGALGVEVVISGKLRTERAHFEKHTIGVVPKSGDIAGQIVTTGVSHVLTKMGLMGIQLRIASKAALPQEFELKDGSAAGMQAAAAPVPETPSEVAEAATAVEQPEGGGKQDGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA9</accession>
    <name>K0IIA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like monooxygenase family protein</fullName>
            <ecNumber evidence="2">1.5.99.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mer</name>
        <name evidence="2" type="ordered locus">Ngar_c17500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.99.11" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17500"/>
    <dbReference type="EnsemblBacteria" id="AFU58683">
        <property type="protein sequence ID" value="AFU58683"/>
        <property type="gene ID" value="Ngar_c17500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17500"/>
    <dbReference type="HOGENOM" id="CLU_027853_5_0_2"/>
    <dbReference type="OMA" id="FYIGGMG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="327" mass="36016" checksum="81BC6EC9E062D1AE" modified="2012-11-28" version="1">MTTTIIGYSLGPLLSMQEVLACAKMADSHQSVDSIWVPESWGRESFVTLGAISQVTKRVKLGTSIISIYARTPATVAMAATTLDMLSGNRTIIGLGASTAAIVENWHGLKFERPVSRMREYIECLKLMASGEKVNYSGKFFKVNNFKILYQPQRKQIPVFMAAINKRMVKLASELADGVLLYLRPLDELKKTVADIKQNTKGKKSFEVASSFICALSNKEPEKARERAAKTLAFYVAVGKYYNKFLSENGFRDEVESITAEYGRGGADAASKFVSDRMLDSLTICGSGEECRKSLTKFVSAGVTLPIIQLNPVGDSESSFREMLSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID5</accession>
    <name>K0IID5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dUTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18150"/>
    <dbReference type="EnsemblBacteria" id="AFU58748">
        <property type="protein sequence ID" value="AFU58748"/>
        <property type="gene ID" value="Ngar_c18150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1793"/>
    <dbReference type="HOGENOM" id="CLU_105318_2_0_2"/>
    <dbReference type="OMA" id="IDIWHFV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1813-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014871">
        <property type="entry name" value="dUTPase/dCTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08761">
        <property type="entry name" value="dUTPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12467" checksum="ACDE8FD5EA67BBCE" modified="2012-11-28" version="1">MDTLEAIFSMQKELASMMDLSRYPTSAEGRVSALSTAIIHEAVELQRLTSWKWWKKPAAFDSMAAKEELIDIWHFVVQASIELGMSPADILEEYKKKNKVNRDRQASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF3</accession>
    <name>K0IIF3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c18500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18500"/>
    <dbReference type="EnsemblBacteria" id="AFU58783">
        <property type="protein sequence ID" value="AFU58783"/>
        <property type="gene ID" value="Ngar_c18500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18500"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1834"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_2"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1848-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="67"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="373" mass="41196" checksum="31F617A822BCFBD5" modified="2012-11-28" version="1">MGIPEKIKEIQDQIHRTQINKATEFHIGLLKAKIARLKREMEENTHGRTVHTGGENVGFDVRKTGDATVVLIGLPSVGKSTLLNRITNAKSRVASYQFTTLTAVPGMLHHRGAKIQVLDLPGIIEGASSGKGFGKRVLSVARSADLVLIVLDVFQPHHLGVLKKELAEAGIKLDERPPDVVIEKTSTGGIGVNAQVPIKVSERLIKEMMRLYGIPNGRIIIREPNLTDDQLIDVLNGNRVYIPSLIVLNKIDLVNKGFIQEVQSKIGNNFIPISADAGVNIDALKEAIYQKLDLIRIYMRPKGGETDYEEPMIMKNGSTVQDVCNKIHRNMAKNFRYGLIWGKSAKFDGQKVGLDHRLEDEDVLTIIKLAGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH3</accession>
    <name>K0IIH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c19010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19010"/>
    <dbReference type="EnsemblBacteria" id="AFU58833">
        <property type="protein sequence ID" value="AFU58833"/>
        <property type="gene ID" value="Ngar_c19010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19010"/>
    <dbReference type="HOGENOM" id="CLU_803196_0_0_2"/>
    <dbReference type="OMA" id="QWDIART"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1899-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="358" mass="41235" checksum="AE8BC8BE4BCC71F2" modified="2012-11-28" version="1">MVDTIRTIKLLGKWSTNRAIGRRRPIIAVFSMTHYCNFYCPMCPFGDSDKEGQMKLVRSRDLTTEQWKAIFDKVSKHCVWSIIEGGEPTSRPDFMELVKYLHSIKMPVTLITNCSLLHTIDLDELKKYIQFITCSVDSTYEEPYCKVRGVTPQVFKRVTDNVRLLTDHKVPHYFNSVITKYNTQEFIDQTYFDRARELGANAVSLTFVEDRSDVNYSLLPDSKTMKEVCESVLDYMKKPGSLPLMIPPEYFQQIIEHGQTLFDECGVWKSVFVNGNGTVMVPCWKFNSPENVYSLLEKSVDEIWDAPQWDIARTCHDCKVLGCIWYSSQPVITFAKNYMRGLGRIIGQKSPELAEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH4</accession>
    <name>K0IIH4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
            <ecNumber evidence="3">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ino1</name>
        <name evidence="3" type="ordered locus">Ngar_c19060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19060"/>
    <dbReference type="EnsemblBacteria" id="AFU58838">
        <property type="protein sequence ID" value="AFU58838"/>
        <property type="gene ID" value="Ngar_c19060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1890"/>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OMA" id="GTKEWAD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="197"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="362" mass="39580" checksum="83A2FE4AEE09D28F" modified="2012-11-28" version="1">MGRKVKVAIAGVGNCASALIQGTRYYRDNSDAHKTDKDWIGLTAYNIAGIEPSDIEFVAAFDVADTKVGKDLSEAIFAKPNNTVRIVKEMDKMDVKVMKGEVHDGVGRHLSQKVKIANTPAVNVAQVLKDTGAEMLLSYLPVGSRRGTQYYAEAALDAGCGFINAIPVFIASTPKWQQAFANRGLPCAGDDVMSQLGATVLHKTLVKLFVDRGVKVDETYQLNIGGDMDFYNMLDEERLEDKRISKTSAVAAMAPYEIPMRIGPSDFVSFLDNDKICYISIKGQYFGGIPVELDLKLKVVDAYNSAGVMIDAVRATKIAIDRGISGPLESISAYCFKHPPVQMPYSVAKANFLEFVEGKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH6</accession>
    <name>K0IIH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type II restriction enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="55351">
        <property type="entry name" value="Nga92ORF27850P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59705">
        <property type="protein sequence ID" value="AFU59705"/>
        <property type="gene ID" value="Ngar_c27840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27840"/>
    <dbReference type="HOGENOM" id="CLU_1100985_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2784-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.91.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038365">
        <property type="entry name" value="EcoRII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015109">
        <property type="entry name" value="Restrct_endonuc_II_EcoRII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09019">
        <property type="entry name" value="EcoRII-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EcoRII-C" evidence="1">
        <location>
            <begin position="101"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="252" mass="29528" checksum="6EB0476B317F283C" modified="2012-11-28" version="1">MLELTESEIAAFLDPALKSIPPPIKILQESIDSLPFKKLEPEYVKNHFSEVMELVTDNAFAKFKVYQRMASRPVIQKFMEKYGPEIEANTKNQKEFVSELLDIFMPVAVSFEFRTSQMRKSRAGTTFEHITVFLLQKCGIKCERTAKSVRKKMNRMDIVIPNQEVALKKPDQAKFLSCKHTLRERWKQALPEKNRNWVMYLITMDDDIPDQKAKEINDHNLIVYVKDQVKAKSYLAKKDWIRKLSDLPKDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0III5</accession>
    <name>K0III5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19310"/>
    <dbReference type="EnsemblBacteria" id="AFU58863">
        <property type="protein sequence ID" value="AFU58863"/>
        <property type="gene ID" value="Ngar_c19310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19310"/>
    <dbReference type="HOGENOM" id="CLU_054974_3_1_2"/>
    <dbReference type="OMA" id="TSMLHWH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1929-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="238" mass="26656" checksum="86A6CDB00C7E1632" modified="2012-11-28" version="1">MLYDNTGLLLQRKTILSVQNIVCETLGTLEQMFRDDGFEIVKINAQSDHVPASSQGYDAIVILGGPMAVYDNLPYLQRQQDLIKDAIKNNTPVLGICLGSQLIAQAAGGRVYKGKKKEIGWQDVYVTPASSNDIFRGVTDKTIRVFQWHGDTYDLPANAKMLAYSDLYPQAFRIGSAVGIQFHLEVDRQLIESWIREYSTEISAERIEPESILPAPGNLEQLAARCRLVYNNFSKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0III7</accession>
    <name>K0III7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57887">
        <property type="protein sequence ID" value="AFU57887"/>
        <property type="gene ID" value="Ngar_c09450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09450"/>
    <dbReference type="HOGENOM" id="CLU_2784237_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-943-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7309" checksum="EBA22E83AF2224C8" modified="2012-11-28" version="1">MLFFTFLKEKKRNATGTTTCSAERAIRPSVVVRKVTYGEPVNDRGQGACSADEYKGDVQAAKGGGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ9</accession>
    <name>K0IIQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29060"/>
    <dbReference type="EnsemblBacteria" id="AFU59825">
        <property type="protein sequence ID" value="AFU59825"/>
        <property type="gene ID" value="Ngar_c29060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29060"/>
    <dbReference type="HOGENOM" id="CLU_1032956_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2906-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="269" mass="29617" checksum="2B80553E9D2D0220" modified="2012-11-28" version="1">MYTGTSVYPSGTKSILDRACTHFVFFYNCKIHPLSIKNCTTLVMQKGSHHSDAHVGHSQGGGYDIGLWTDPANLQSSKSSELSMIVTEQQTGGRVGQFEIIHDKLMHLVVVSDDLSYFAHVHPKFNDREKVFAITHTFPAAGRYRMWVDVKPKGAGQLIKKFDLNVDGKPARQPIPIVADRNFAKDIVAAGGQKHYRVQLKVPERINAGKDTEIMFELSDSQGRPITDLEPLMAAGGHCVIISSDAEVSPCPSYRGGGCRMARRAKSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ2</accession>
    <name>K0IIZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21320"/>
    <dbReference type="EnsemblBacteria" id="AFU59063">
        <property type="protein sequence ID" value="AFU59063"/>
        <property type="gene ID" value="Ngar_c21320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21320"/>
    <dbReference type="HOGENOM" id="CLU_1529281_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2130-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19688" checksum="2ABB4888D20D0826" modified="2012-11-28" version="1">MMPVDTYTHTGRHMILGKGDFGSFMLQKIAELEARSGIQLGLAQKILLAETGTVEQVLSILTNSTIRVKVLEQKENARTITRQSIITNDAGRVLIKAHSKVFKRNLPAKVVSQIKRKESGIGTIIATHGLETFRKIVQVGYDPVSKSVFRKYQIICRKKVAFEIREELVGEFTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ9</accession>
    <name>K0IIZ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59073">
        <property type="protein sequence ID" value="AFU59073"/>
        <property type="gene ID" value="Ngar_c21430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21430"/>
    <dbReference type="HOGENOM" id="CLU_3003264_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2141-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6773" checksum="D2D4CB272093584E" modified="2012-11-28" version="1">MSLYRIKKVEHYLSNPNIAKKTRFRRGQTRWLEASLMTGLQEDNFLIVEWKFPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ18</accession>
    <name>K0IJ18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c30840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60000">
        <property type="protein sequence ID" value="AFU60000"/>
        <property type="gene ID" value="Ngar_c30840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30840"/>
    <dbReference type="HOGENOM" id="CLU_1122649_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3084-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002386">
        <property type="entry name" value="Amicyanin/Pseudoazurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00155">
        <property type="entry name" value="AMICYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="4">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="247" mass="25091" checksum="9914373046042868" modified="2012-11-28" version="1">MAPEPKKDDAQKGGYSPDMKTVGLAILAMGISLLLVIIAWMAIGVDPDYSAEVMQEQQASLREQYGLPPEETLTAAQLETPPSLRGLENATDNATSLATSSNATGSNQTTTIVGNQTAAGNATGIGNQTSAAPGNQTNQTAATGNATAAAPAGGTAAVSIVQGASSKTNDAYNPNPAQISAGSAVTWTNDDSVPHTATSGQNATPDGTFDSGILQQGASFSFTFEEAGEYPYFCTLHPNMVGTVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ80</accession>
    <name>K0IJ80_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59158">
        <property type="protein sequence ID" value="AFU59158"/>
        <property type="gene ID" value="Ngar_c22280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22280"/>
    <dbReference type="HOGENOM" id="CLU_160448_0_0_2"/>
    <dbReference type="OMA" id="CIYEETA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2226-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041183">
        <property type="entry name" value="Cyclophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18050">
        <property type="entry name" value="Cyclophil_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="13879" checksum="4B8F3AA9A8AA97B3" modified="2012-11-28" version="1">MQQPPAGSVSRFKLTIEIANKGSASAELVRHLAPLTSNAILKALPLQDRIHRYADKFAYIETGLVIGAEKQKTQFRRGDLAYLTTNGSICVFLQDATVQPMNPLGIITGNIEVVESSQPGDVMVVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ86</accession>
    <name>K0IJ86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58297">
        <property type="protein sequence ID" value="AFU58297"/>
        <property type="gene ID" value="Ngar_c13590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13590"/>
    <dbReference type="HOGENOM" id="CLU_1801757_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1357-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="16422" checksum="6AA1C33B683253D0" modified="2012-11-28" version="1">MSQKNSDDKMVLQIRGGEMRLVAATSDAGRKYMEQVMQEDEQRNNYVDEIIARKLELGKIGQGQVKEEKEKLYKLSIDTLAEISATLEEALQQQHTVAQTHTIQPRPAEYRPHFKASEQEGYYSSGKMGDEVIKRFRDISRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ91</accession>
    <name>K0IJ91_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58307">
        <property type="protein sequence ID" value="AFU58307"/>
        <property type="gene ID" value="Ngar_c13690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13690"/>
    <dbReference type="HOGENOM" id="CLU_1709039_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1367-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="19899" checksum="473167E05BFEB78D" modified="2012-11-28" version="1">MQRGWLDFRNGHSVYLSFILTFMNSILIAYNFAVSQFAFLNNIFYSVGLFALFFLGVYIPTSVIIGYWHRRHQWIVENEALLQENWVWAWIARYQIRLIEGKATYEETKQVLDYLEAILQRQKNGACLTGGKDIAMNHGANTWKRSSADSGNTKEEKIYSLTLAQSQIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ5</accession>
    <name>K0IJJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c32750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32750"/>
    <dbReference type="EnsemblBacteria" id="AFU60190">
        <property type="protein sequence ID" value="AFU60190"/>
        <property type="gene ID" value="Ngar_c32750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32750"/>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="OMA" id="TIRAENN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3275-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="389"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="610" mass="67903" checksum="6C2404A7B14724BC" modified="2012-11-28" version="1">MSLCTWNDVVMEKRLEKNASRWLIPAVIGVAVVAGLAFAILYVTYNNTEANIRQSLFEQQKDRQLETTKALAQHIGSDMDSILMRLEALANIELLQNGDLTSPEVRQLAQKYFDTANEISYVDYLFVFDKDDVAVLNIVDSPEQQTLEGADFSERDYVQQAHATRAPVFSDGFQGIDGKYRIAIVHPIINRETKEYVGLVGVAIPTIDLFGRYGNIYQIKSQYLAVLDTNANHLVHGNHDLIGKNFFDEYTQQFTQQNADLNNAMRQVLSGQPAHTVYTIEAGERLTSGHPVFVQNKLAYVVFVVTPTSVIYSNINSILAAERTQVFVQQVALATAVGLFVAFAVWLNRNLNKEVKRRTQELENANRQLAEANEQLKANDRLQKEFINIAAHELRTPIQPILGATELIDAGFENKDRVEITKPELDLIVRNAKRLERLSSTILEVARIESNSLKLNRKILDINERITNIIADVRVTLDSNGKTKKKGLKLLFEPKNSPILVEADEERITQAISNIVGNAVKFTESGSIVVTSEAKDDHAIITVKDTGSGIDPEVFPKLFTKFASKSEKGTGLGLFLTKNIVEAHGGTIRAENNENGKGATFTFTLPIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN7</accession>
    <name>K0IJN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60270">
        <property type="protein sequence ID" value="AFU60270"/>
        <property type="gene ID" value="Ngar_c33550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33550"/>
    <dbReference type="HOGENOM" id="CLU_154322_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3355-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="159" mass="18513" checksum="728D837EA3399C52" modified="2012-11-28" version="1">MPSTTVPSKIEWPDILNESVHTSDDVDIGDIYALSRDFVVVKRGIIHKIHYYYIPINKVEGWDGNVLWLKITEDEVKRNYERDRNPNPLRYSLKDYPAYSGATYPELMIISPKGEKIAYTDTTTAQTEKEEERVIYKCDLCDSQFRTEEELSRHVPASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX2</accession>
    <name>K0IJX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60410">
        <property type="protein sequence ID" value="AFU60410"/>
        <property type="gene ID" value="Ngar_c34970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34970"/>
    <dbReference type="HOGENOM" id="CLU_1242980_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3498-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="25586" checksum="CDBF20324BA27C5E" modified="2012-11-28" version="1">MVVEEVRYDFEEFPRYADDFIRDLLKLMIISKMNAAVKNPTSANHFLHLVSQIEGCDAYVVKYGQPLLYAKYHGMEFTDQKVTSQFVRSKNHVIDVTMESVFGDFVKRFDSLASATKSKVKWGVVPKEKKEDKPDPLFALLDSFVGTVVRLTSLDPVSEDSLVGKRFGIRNASMARKSLHIEFLINGHLNILEINPEKKRKEDKAKLLFAKSEAAKAIVALMKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJY8</accession>
    <name>K0IJY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58592">
        <property type="protein sequence ID" value="AFU58592"/>
        <property type="gene ID" value="Ngar_c16590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16590"/>
    <dbReference type="HOGENOM" id="CLU_2730542_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1657-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8362" checksum="9FB68DF9245EFD48" modified="2012-11-28" version="1">MHICVYIKNTYYKLICQGALNLCMMKLYICQSCDAVFWSDLDAQHHSRNNLYGKYSEYDLEDLLARFLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK69</accession>
    <name>K0IK69_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ordered locus">Ngar_c17390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17390"/>
    <dbReference type="EnsemblBacteria" id="AFU58672">
        <property type="protein sequence ID" value="AFU58672"/>
        <property type="gene ID" value="Ngar_c17390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17390"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1713"/>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_2"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="15714" checksum="C7B1C17850984616" modified="2012-11-28" version="1">MATGAKSRAVSAKGVEEFRPYITRALPVTAELVCADNTGAKVLRIAMVNRYKGRHSRMPAAAVGDFVTVTVKKGPAELRKQIFGAVIVRQKYPIRRLNGVRVSFEDNAAVLVTPEGEIKGTDIKGPVAAEAAEKWPRIANLAGMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKD2</accession>
    <name>K0IKD2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58842">
        <property type="protein sequence ID" value="AFU58842"/>
        <property type="gene ID" value="Ngar_c19100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19100"/>
    <dbReference type="HOGENOM" id="CLU_2911652_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1908-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6431" checksum="9DDF764024958D55" modified="2012-11-28" version="1">MTVTVPAEEQGTIKHIDMVVAASAGFASGEFIAPIAVNLAPSFNYGYLVLVGFIFDICIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKL0</accession>
    <name>K0IKL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20810"/>
    <dbReference type="EnsemblBacteria" id="AFU59012">
        <property type="protein sequence ID" value="AFU59012"/>
        <property type="gene ID" value="Ngar_c20810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20810"/>
    <dbReference type="HOGENOM" id="CLU_2313875_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2079-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="10439" checksum="17CB81879FA4257F" modified="2012-11-28" version="1">MLYTGVGLTTIAAAIGVFVSLKNRQEIQTKSFYTAFKLLIIGAAIQLVSGPGDFMWHSVFGVDGLMSPPHLALATGILVNAVAVVVGLARILPHMQSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR6</accession>
    <name>K0IKR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59928">
        <property type="protein sequence ID" value="AFU59928"/>
        <property type="gene ID" value="Ngar_c30100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30100"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3010-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="21632" checksum="A3BD671A6079E5C0" modified="2012-11-28" version="1">MDNKSSSYFYREVMSLDCPMIGHVVRETEDRIVVFGLGDDRYDILKTEIQSDSSERIMIGLPLYEIARRYKRSRRESLPRSRKDLEDGVYQLSSEGEKEHQIIPSLSYKSVVTMDKEHVGHIISETKNKIIVFGHYMYRFDIPKSEIHSINTKNTVILRMRYDNVFRYGVDRNAQLPGSQFSAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS5</accession>
    <name>K0IKS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative heavy metal transport/detoxification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c22120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22120"/>
    <dbReference type="EnsemblBacteria" id="AFU59142">
        <property type="protein sequence ID" value="AFU59142"/>
        <property type="gene ID" value="Ngar_c22120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22120"/>
    <dbReference type="HOGENOM" id="CLU_134973_10_4_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2210-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8589" checksum="F923597946DDA44D" modified="2012-11-28" version="1">MTSTQKARFKVVGMYCTTCKPIVENQLKGNQAIKKVEINFMTDSVIVEYDPALITKEEIKERLQNSGYQFVRLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKV1</accession>
    <name>K0IKV1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60013">
        <property type="protein sequence ID" value="AFU60013"/>
        <property type="gene ID" value="Ngar_c30970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30970"/>
    <dbReference type="HOGENOM" id="CLU_1891503_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3097-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031876">
        <property type="entry name" value="DUF4760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15956">
        <property type="entry name" value="DUF4760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="16383" checksum="A20F29A3FB09CF92" modified="2012-11-28" version="1">MAKRTTAQDIDILFRLAELYNTDYDFQSIEWFWGRFHERTIEEFTSKYAHGSREYQFFERFTSKFELAGLLVEKGFLNEDLFFDRYGSLQAEWNKCKPIVYGLREKWNEPRHRENFELLAERGKKWQDKHPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL00</accession>
    <name>K0IL00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60078">
        <property type="protein sequence ID" value="AFU60078"/>
        <property type="gene ID" value="Ngar_c31620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31620"/>
    <dbReference type="HOGENOM" id="CLU_1381444_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3162-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="22687" checksum="C9A4A7E4EB9B5432" modified="2012-11-28" version="1">MTNLMVYSPVEDDRLSRFLSDRPKFKLYAATQHLNNLKSIEARHESLVAPKARIPAEMEIDSFLDKMLGAVDSLFVQINEKLDLGIPIDQLDFGHVQSALSAKTKRIDLLSDLDKARQYGNWYRQLIELRNSSMRESLSKLVIVGPDSMKAYFKKNSKDPDNSPPMELEVIPYFEQCLSSMERLIEMIRNSDPRFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL86</accession>
    <name>K0IL86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme-containing membrane protein CtaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctaA</name>
        <name evidence="6" type="ordered locus">Ngar_c00040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00040"/>
    <dbReference type="EnsemblBacteria" id="AFU56954">
        <property type="protein sequence ID" value="AFU56954"/>
        <property type="gene ID" value="Ngar_c00040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00040"/>
    <dbReference type="HOGENOM" id="CLU_1860763_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU56954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16450" checksum="56BD1310827CDA87" modified="2012-11-28" version="1">MEEVQHSRPKVAVGLSFSALAMLYSVMLVGVYITASHQGLSCPDWPLCPNGFDLPPERYFFEHYHRLMVVVAAGLIYATAIYAVKNAHPARKTAVIAAIVVSVQIVIGMFVVLTKLQALLVATHLSTGILLFAMLLMTFLTSYRLARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC7</accession>
    <name>K0ILC7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57004">
        <property type="protein sequence ID" value="AFU57004"/>
        <property type="gene ID" value="Ngar_c00540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00540"/>
    <dbReference type="HOGENOM" id="CLU_958524_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-54-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="319" mass="34931" checksum="A33E8062DEF4AC5B" modified="2012-11-28" version="1">MGQNVVSRTSVVLLILIVPLSALMVATLFMEEGLFSSPEEVDEEIAHGEEIGRLNATIFKLGDVTDSSLTNVNLAIFDYFMAEKKPLTVGVIVEDFGNAAPHGIIYKKVKQGHDSGLFEMAIHGFSGGGTTYDQLDYETQLKHFKFANTKLTKLLGSPSEIFAPPRNKFSADTIRAMANSDPPISIISVGNQSDNITLNPYKLNSTYDTGKGIVGGISDVNGTKIYHVVHDISYLKFRTQNYTGDSLQDVVVQRAQANIEKYGFAVVILHPTDFCVIDEATGMCTNQVDPERFKILTDTVDELESLGYGFAKMGDVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH7</accession>
    <name>K0ILH7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60428">
        <property type="protein sequence ID" value="AFU60428"/>
        <property type="gene ID" value="Ngar_c35150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35150"/>
    <dbReference type="HOGENOM" id="CLU_1444622_0_0_2"/>
    <dbReference type="OMA" id="WYCVSRI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3516-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="20914" checksum="DA2798CC8AC6C18A" modified="2012-11-28" version="1">MRATVEKDDLKARKIFLGIFYFCAFMMAIITFYAIYVSLNEYMQTGRVVIGEVLVETEFPFPGLAKLVTYLMIVSVVGWYCVVRLGGDKVKSIPKWLKSILQLIVLAIAVVSLYEFVYNFIVWNSLMTADVMRGIINFDDINVEYPSPNTPWNLVFATKMSLAAFLISAHGFYTMSKPERKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI4</accession>
    <name>K0ILI4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="11" type="ordered locus">Ngar_c01490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01490"/>
    <dbReference type="EnsemblBacteria" id="AFU57099">
        <property type="protein sequence ID" value="AFU57099"/>
        <property type="gene ID" value="Ngar_c01490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.149"/>
    <dbReference type="HOGENOM" id="CLU_007952_3_0_2"/>
    <dbReference type="OMA" id="HRCLQMT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="62"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="345" mass="40368" checksum="4EAC1E76F2E3134E" modified="2012-11-28" version="1">MSCSDEHVSHSTDNNLIQITPQLKARLQKAKYGVYNHSAVELCHWTKKSFANEGTCYKHKFYGISTHQCMEMTPTAMNCENRCIYCWRPTEFYDTLEMPEELVDEPDVIVQQLMVERKKLINGYYGNAKNDKKKLDESLLPAHYAISLSGEPTMYPKLPQLIKYLKSLKATKSIFLVTNGQEPDMLKRLAAEDALPTQIYLSTNASNKKMFHQVNRPLHKDAWERWWESLRFLATVNTRTVLRMTLIRGYNDSDSFVGEFAEMMAQGDPHFIELKSYMHIGMSNQRLEQDHMLEMHEVRDFAGRLCEKMPSFKVMDESEISRIVVLQNQVRYTDRWIREYLTPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU6</accession>
    <name>K0ILU6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57364">
        <property type="protein sequence ID" value="AFU57364"/>
        <property type="gene ID" value="Ngar_c04170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04170"/>
    <dbReference type="HOGENOM" id="CLU_3075466_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-416-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5755" checksum="CFE8B5BCA08CED3F" modified="2012-11-28" version="1">MYTTDIDSGTVSIINATNNMLIRQIDTGERAVHGIAIFNDMLYVGMSMAERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX3</accession>
    <name>K0ILX3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57419">
        <property type="protein sequence ID" value="AFU57419"/>
        <property type="gene ID" value="Ngar_c04750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04750"/>
    <dbReference type="HOGENOM" id="CLU_2191105_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-473-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12623" checksum="4ACF5B8F678C3815" modified="2012-11-28" version="1">MDVFISMMENNGNNYSAMMQWLKATFSKIPNEYGNILIYATLVGPRPDEACQSINLIQTDLDNYLKKDWMTLEHYKYPEIFIRRTKKAYISIINQEVIELARSCKNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM08</accession>
    <name>K0IM08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c29440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29440"/>
    <dbReference type="EnsemblBacteria" id="AFU59862">
        <property type="protein sequence ID" value="AFU59862"/>
        <property type="gene ID" value="Ngar_c29440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29440"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2919"/>
    <dbReference type="HOGENOM" id="CLU_1010542_0_0_2"/>
    <dbReference type="OMA" id="FFINRKY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2944-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="275" mass="31125" checksum="EEC6136A7808A52C" modified="2012-11-28" version="1">MTNERVVLDNDLRYIERGRLLRSRSELSVAKMLSFLGHDYQYDASVKLPEGKSVKIDFKAGSKYIEVIDSEDDAAKFKQVRDRLPDLDIIAVGHSKYASKISEMDSLFFYDSTEDHLQTGSIFIEDPSLAFDYAHILPLVEKCSVLHGHTSTVMVEIIGSMKNNLVIDFGEAKRIIKETLNAIDHKFFINRKYLQKEDDVHYYVAFDGPKGYFSLQLPKSTTYMLSGEATVENLSSEIIRLLAPKMPQNVQALGVYIYEGVNKGAHIIAGVKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM47</accession>
    <name>K0IM47_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease subunit gamma</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureA</name>
        <name evidence="3" type="ordered locus">Ngar_c06110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06110"/>
    <dbReference type="EnsemblBacteria" id="AFU57554">
        <property type="protein sequence ID" value="AFU57554"/>
        <property type="gene ID" value="Ngar_c06110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.587"/>
    <dbReference type="HOGENOM" id="CLU_145825_1_0_2"/>
    <dbReference type="OMA" id="MQLTPHE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11198" checksum="AF0DD10FF39CC28F" modified="2012-11-28" version="1">MMLAPREMEKMWIWTASQIAEGRKKRGVKLNYPETVAYIANYVVEGAREGKSVAELMQSARSILKKSDVMPGVPELIHTVQVEATFPDGTKLVTVHDPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM79</accession>
    <name>K0IM79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60077">
        <property type="protein sequence ID" value="AFU60077"/>
        <property type="gene ID" value="Ngar_c31610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31610"/>
    <dbReference type="HOGENOM" id="CLU_166567_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3161-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11248" checksum="E22C6BF970E90EBE" modified="2012-11-28" version="1">MRKSTQPVSSSTLVVRNNNVDEGVIAFGLWLNFEGKDSPAVPITMKKFDQNREVVLHDNVLQKDVSVGIVEGVPICNECRTNDCAHVGFAICAEQMHFSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME5</accession>
    <name>K0IME5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60197">
        <property type="protein sequence ID" value="AFU60197"/>
        <property type="gene ID" value="Ngar_c32820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32820"/>
    <dbReference type="HOGENOM" id="CLU_1381445_0_0_2"/>
    <dbReference type="OMA" id="HVLRWIS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3282-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="22114" checksum="A04ECBE77510957F" modified="2012-11-28" version="1">MAGFSNQFSKKEASILQLIIEENLSNFIFDGIKRKIGMHQETLSRALDELERAGVIAKTNQGYRVADNIREEHHFATPLSYNPSSSVYVAVPLIQTILPEDVDSQSILSGLQGKWFGMLRWFGSSETESSITLKWLTVDGKVQIDALFSDSSLIIEGKLLQNKNNNKNKDLSNAVRASHQLMEQIIKLYSKQNNAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML3</accession>
    <name>K0IML3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60387">
        <property type="protein sequence ID" value="AFU60387"/>
        <property type="gene ID" value="Ngar_c34720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34720"/>
    <dbReference type="HOGENOM" id="CLU_153619_0_0_2"/>
    <dbReference type="OMA" id="YDHAIVT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3473-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="11766" checksum="46B16D79AC2FE574" modified="2012-11-28" version="1">MANELWSAIVFVVGLLISTVIIYIAAKLLGQKEGIGRAFVTAIIGTIVYSIMYFIFGTGWIAAIVGGFVWLIALRGLYDIGWLKAFVIAVIVWIAATIVGLLLPTAPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM7</accession>
    <name>K0IMM7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cysteine desulfurase</fullName>
            <ecNumber evidence="3 5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sufS</name>
        <name evidence="7" type="ordered locus">Ngar_c10870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10870"/>
    <dbReference type="EnsemblBacteria" id="AFU58029">
        <property type="protein sequence ID" value="AFU58029"/>
        <property type="gene ID" value="Ngar_c10870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1030"/>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_2"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="29"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="414" mass="46445" checksum="D2E4469C1BB75544" modified="2012-11-28" version="1">MQKSALNIEKIRADFPILNRKVSGGKPLVYLDNAATTQKPLTVIDAIHDYYMNYNSNIHRAVHQLAEEATLAFEKTREKVAKFINAKSTEEIIFTRNATEALNLVAYSWGRANVKKDDKIVITEIEHHSNIVPWQILTSEKGAKLEYIGVDDNGYLKMHEYKSHLDSNKVKLVSVTHMSNVLGTIVPVKDIIKMSHEKGIPVLIDGAQSVPHMTVDVQKMDCDFMAFSAHKMLGPTGVGVLYVKKEILEKMPPFMGGGDMIKEVHKYETRYNDLPYKFEGGTPNIADVIGFAAAIDYLNNLGMDRVREHEIELTKYAIDRISGVKGVTLYGPRNTNDRGGVVSFNIGDIHPHDLATIMNDHGVAIRSGHHCAQVLMERLDVSATSRASFYIYNTKEEIDTFIGALDEARRLFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM9</accession>
    <name>K0IMM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58034">
        <property type="protein sequence ID" value="AFU58034"/>
        <property type="gene ID" value="Ngar_c10920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10920"/>
    <dbReference type="HOGENOM" id="CLU_2177958_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1090-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="13226" checksum="7FBBC67B969F62C3" modified="2012-11-28" version="1">MAYDLVAIPTIHDFFERHKSEMADKYVDTLFVIYRPHNNEIFFSIWYSLPLYKTMNATVMPDRYTLTSLDEISFKIPILKQFPELNDENYQPWIDFNILQYNFCCRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR1</accession>
    <name>K0IMR1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60502">
        <property type="protein sequence ID" value="AFU60502"/>
        <property type="gene ID" value="Ngar_c35890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35890"/>
    <dbReference type="HOGENOM" id="CLU_1640044_0_0_2"/>
    <dbReference type="OMA" id="ETHSIRQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3590-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="162" mass="19062" checksum="01C6065ECA8A3442" modified="2012-11-28" version="1">MVDWDEQIKAHLFWVWNEGESFFKRGREGMLVITDKRLAFITKTEMSYKMHETHSIRQAKRFEAGENVFRPAEGYKLEHLERDLDKSPDNLEILFSQIIDITSEEKRWGTLLKVKVNLGDRSKVYKFSIAKGWLKYPAKDPMGFQKMDWSPLINLVKTSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU2</accession>
    <name>K0IMU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58219">
        <property type="protein sequence ID" value="AFU58219"/>
        <property type="gene ID" value="Ngar_c12790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12790"/>
    <dbReference type="HOGENOM" id="CLU_2730539_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1277-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7965" checksum="0E9AFB191DA6E2FD" modified="2012-11-28" version="1">MCKTLQTKWFKAASNITSMKDSRKKEEKDAAATTDYDNDKRFQNLLEYLGLSQYPGLISILKKLGSGTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW4</accession>
    <name>K0IMW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58329">
        <property type="protein sequence ID" value="AFU58329"/>
        <property type="gene ID" value="Ngar_c13920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13920"/>
    <dbReference type="HOGENOM" id="CLU_2461865_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1390-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10156" checksum="92BC2BA247D37368" modified="2012-11-28" version="1">MMLYDLQADTKKAPPILIRGRVSLDFRINGGVSQVIIDYEYYPSNDTLNYVDVRYTNNKLKSKVEGDPTMMRNIDSYLRRLLAQNPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW6</accession>
    <name>K0IMW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14020"/>
    <dbReference type="EnsemblBacteria" id="AFU58339">
        <property type="protein sequence ID" value="AFU58339"/>
        <property type="gene ID" value="Ngar_c14020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14020"/>
    <dbReference type="HOGENOM" id="CLU_083583_0_0_2"/>
    <dbReference type="OMA" id="PFYAVGQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1400-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="23047" checksum="02A64E5FD40349C0" modified="2012-11-28" version="1">MKKFRDRVDAGNLLAERLAKTSHTHVIVLGIPRGGVILANIVAKKLGADFDIVIPRKLGAPGNEELAIGAVMEDGTSYINRYIVDALRISQDYVESETARQAAEIRRRSAAYRKPGAYRIAGKNTILVDDGIATGATVIASARWARKQSPSRLIVAVPVAPSQSVEALEQEADSVVVLATPRDFTSVGQFYEEFAPVSDEQVMEIMRSRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY6</accession>
    <name>K0IMY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58439">
        <property type="protein sequence ID" value="AFU58439"/>
        <property type="gene ID" value="Ngar_c15040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15040"/>
    <dbReference type="HOGENOM" id="CLU_3245477_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1502-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="42" mass="4753" checksum="B8260F1E2EDA099C" modified="2012-11-28" version="1">MFLQAKPQCRQISFGVSCAAAYIRNDFQEPLSVLPGFFKMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN04</accession>
    <name>K0IN04_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c15960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15960"/>
    <dbReference type="EnsemblBacteria" id="AFU58529">
        <property type="protein sequence ID" value="AFU58529"/>
        <property type="gene ID" value="Ngar_c15960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1564"/>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OMA" id="GEYMRTG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1594-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="2"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="404" mass="44840" checksum="4F72B68E4A12FE4F" modified="2012-11-28" version="1">MIKIGLIGKTNTGKTTFFNSATLLSAEISNYPFTTKQPAIGNAHAITLCVHKEFNVQDQPKNSRCIDGWRFIPVELVDLPGLIKGAWEGKGLGNQFLTIAAQSDVLLHIVDASGSIDASGKIAEPGSGDPIADVADIEEELVMWYLKLLEGNRDKISHAISTGTETVPAITEVFRGIGVREEHVKLALAQNNLTDVPFEDFGPQESKDFCWSLRDISKPTLIVANKVDLPTATENFNRLREEYKDVIVVPASADAELTLRRAESKGIIRYLPGDERFEINDQTKLNDKQKWALNFIRKDILGEYMRTGVQFAINVAVFKLLKMNAVYPVADAQKFSDKHGNVLPDVYLMRSGSTVEDLAREIHSELAKGILYALDARDGLRLPTNYQLKDRDVLSIVSARTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN27</accession>
    <name>K0IN27_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58644">
        <property type="protein sequence ID" value="AFU58644"/>
        <property type="gene ID" value="Ngar_c17110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17110"/>
    <dbReference type="HOGENOM" id="CLU_1168604_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1709-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="237" mass="26336" checksum="BBD109B8FB401617" modified="2012-11-28" version="1">MEQGQDHDCSVFSATDFETGEQVCIKCGMVTQEADNRDIYVSDLEGRMMNATSSYAGNGLLNSETENMDYVSKKNPGLAYKINRGGKDFQGRRVKTSLNDAYRSGCIAGGKEMIVKQDPLTGEVSLKFNGYDKPMLRMVKERAMSELSRYNLDTVEMTIVAKECKRIVSQLFFGPMLEYAWMAAAINAGVLKKRDALAIEKAMYDLMEPIRVLLLSHGDKTLAAELTKPAQPIEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN47</accession>
    <name>K0IN47_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA repair and recombination protein RadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">radA2</name>
        <name evidence="2" type="ordered locus">Ngar_c18110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18110"/>
    <dbReference type="EnsemblBacteria" id="AFU58744">
        <property type="protein sequence ID" value="AFU58744"/>
        <property type="gene ID" value="Ngar_c18110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18110"/>
    <dbReference type="HOGENOM" id="CLU_041732_2_0_2"/>
    <dbReference type="OMA" id="GNTLEHW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="24459" checksum="47290698DB274A93" modified="2012-11-28" version="1">MATTISTGSKAIDSLLGGGGIRTGMLTDVYGESGSGKSQLCFTLCANCARAGGTAIFVDTAGTFRPERIVEISGSPGALEKINFIRALNTLDQTNAIRKILDTGPQLVVVDTLTSLFSAEYSGPARHLAVMKHMHELALAAINAGCAVVVTNMVRNAPITVVDQAGRNIAQAVVPSQQREYLGSSVSIYSHIKVKLEIVDAAKSSFRALLVQSAGKEPVPFSITPRGISDIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN65</accession>
    <name>K0IN65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58834">
        <property type="protein sequence ID" value="AFU58834"/>
        <property type="gene ID" value="Ngar_c19020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19020"/>
    <dbReference type="HOGENOM" id="CLU_2420145_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1900-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10170" checksum="C6D4E6AD99A80963" modified="2012-11-28" version="1">MGSSLLSSDNYERFLHNVQEQIDNADKEMKKNAEKTLRLIADNYHKLVSERLAIELGLIDDALATGNDAAARHHRVLADVYRSMLDGCQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN85</accession>
    <name>K0IN85_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58934">
        <property type="protein sequence ID" value="AFU58934"/>
        <property type="gene ID" value="Ngar_c20020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20020"/>
    <dbReference type="HOGENOM" id="CLU_049414_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2000-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="331" mass="38547" checksum="72001DC036D07DC6" modified="2012-11-28" version="1">MQYLVNVVHGISDQLKLMPEIIVSYGVSLDSAKRKEIAIEYWRNFLACFNTAYPQMQKTNTINTYRSFLAAHNINFAHGEGRRYGLSTTPERLGEYKEIMLTPEQIEKINRRLENEGDWEAWSFMNIDLHTGARAFAMASMSWERIAFSPLFRVEQFEPKVKRGDWCLTKEGKWWVKYPTEECRTVVETARERLPKGRRFLFFEDVKSDRANALQASYLMSRMAVRFKKIFLELDRDSWLNEKTRVYALGDGVYFSGHPLHLFRHTMAQYYLAATNWSLAYVAGLGGWENTEVLNKCYGGIPEHIKAQVAKSIHVRFDTLDLSTTVRVVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN98</accession>
    <name>K0IN98_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) polymerase subunit PhaC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">PHB synthase subunit PhaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phaC1</name>
        <name evidence="7" type="ordered locus">Ngar_c20680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20680"/>
    <dbReference type="EnsemblBacteria" id="AFU58999">
        <property type="protein sequence ID" value="AFU58999"/>
        <property type="gene ID" value="Ngar_c20680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20680"/>
    <dbReference type="HOGENOM" id="CLU_035017_0_0_2"/>
    <dbReference type="OMA" id="YLIDWGY"/>
    <dbReference type="UniPathway" id="UPA00917"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010125">
        <property type="entry name" value="PHA_synth_III_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01836">
        <property type="entry name" value="PHA_synth_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0583">PHB biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="378" mass="42904" checksum="DC8B9B06882E261F" modified="2012-11-28" version="1">MAKQELRPDQKPEVQPPAAAAEKAKEAKKKEPTVLEEFEEAYRKLEKAKNILHTAGNIEVGQTPHEILAETRTYRLLHYQQMVSKTAKTPILVVYALINKSYVLDLQPDKSWIRSLLSQGFDVYLIDWKAPTAVDKYVTFDDYVNCYIDDCVNIVLKKTKADKLTLHGYCMGATMSTMYTTLHQEKVRNLAVIAPVVDTEKDTTVIGNLAKNIDVDKMVSVIGNLPVEQLYACYSALKPFKQGVNKYFNLVQNIDNDQFVGNFLRLEKWLYDTPPIAGETFRQWIADIYQKNLFVKNELKLGNELIDLSKIKVPLLNIVADEDHLVSPQCSAPLNDVVSSTDKRLMRFHTGHVGLIASLYSQNNVLPKVGQWLKARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB0</accession>
    <name>K0INB0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59059">
        <property type="protein sequence ID" value="AFU59059"/>
        <property type="gene ID" value="Ngar_c21280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21280"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2112"/>
    <dbReference type="HOGENOM" id="CLU_1998647_0_0_2"/>
    <dbReference type="OMA" id="KHEYIRE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2126-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="15257" checksum="8F3042673B477D66" modified="2012-11-28" version="1">MDDFERDFPDFDWKNTPAYKHPGGKDCPCPKHEYIREQINVAKTVSENNKDVSPEFRQRAQVTLKFCPDHYDVYFNEVVPSMPLKYRFMTKVALKLGAISIQKLTYMQSDQCFYCKFGSGGFDKKAELPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF7</accession>
    <name>K0INF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59294">
        <property type="protein sequence ID" value="AFU59294"/>
        <property type="gene ID" value="Ngar_c23690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23690"/>
    <dbReference type="HOGENOM" id="CLU_2313876_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2367-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="10837" checksum="645ECC460B54380F" modified="2012-11-28" version="1">MLDAIVDGIEDVMGKDSGRLIMQTMKTVYKINEEAILSNPSLFQEKMQKMLGSTSKMVLDSASKKIKEIVLLAGIIAVIHPCIFFNNAIPETGIISPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF9</accession>
    <name>K0INF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nucleotide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c23790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23790"/>
    <dbReference type="EnsemblBacteria" id="AFU59304">
        <property type="protein sequence ID" value="AFU59304"/>
        <property type="gene ID" value="Ngar_c23790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23790"/>
    <dbReference type="HOGENOM" id="CLU_109674_0_1_2"/>
    <dbReference type="OMA" id="GCGREFD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2377-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_6" evidence="4">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="18119" checksum="78A58977A2793F97" modified="2012-11-28" version="1">MDSQNSSSRYALDASAFYAGTPFLSSAVSYYCTTQAILDEVKHIKKSHGAIEALSAAGNLEIIDPGKSSIEKVKAAAKKTGDYRKLSQADVSIIALALQLETTLLTDDYAVANVASALKIPVKSSSGKGIKETRKWISYCSACGRAFGPEAKECPLCGNKLRRKYRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK2</accession>
    <name>K0INK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59519">
        <property type="protein sequence ID" value="AFU59519"/>
        <property type="gene ID" value="Ngar_c25970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25970"/>
    <dbReference type="HOGENOM" id="CLU_2646048_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2597-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8969" checksum="C996F03A9466358E" modified="2012-11-28" version="1">MLRQAAIHNKDTSVEQFAKGLGIRLDKLVVLNEKDCIKIKPKGWLEKKEWREINDILRMQGFNWLANDKNSCWIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM7</accession>
    <name>K0INM7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF151 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27230"/>
    <dbReference type="EnsemblBacteria" id="AFU59644">
        <property type="protein sequence ID" value="AFU59644"/>
        <property type="gene ID" value="Ngar_c27230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2702"/>
    <dbReference type="HOGENOM" id="CLU_1782437_0_0_2"/>
    <dbReference type="OMA" id="HMRAFSG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2723-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="16017" checksum="B2C4E012F9DCD133" modified="2012-11-28" version="1">MPDLQDEEYIPARISYVGFVDQVGLEGVVVLKSEDGKEFPMRAFSGEVARHISRFQEGDKGSIPTIYNLVEEIAVMQDLLLVEVHVYQSGSVLRANLYFKSKKDGELVLRNYRASDSIALAAYYDIPIKVRKNLFEEAIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN2</accession>
    <name>K0INN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59669">
        <property type="protein sequence ID" value="AFU59669"/>
        <property type="gene ID" value="Ngar_c27480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27480"/>
    <dbReference type="HOGENOM" id="CLU_140803_0_0_2"/>
    <dbReference type="OMA" id="FIGVFMY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2748-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15903" checksum="F5EBC662FF4480A4" modified="2012-11-28" version="1">MNSGYPAEKANHWDIKCMQGEYEHFGVFWYRYGTPFDKEPVHGICFYFNDIPRKTVDELASFLQSKFGGQLLYRQARGFLQGSKEFADGKSVAILANELSLKFNAPVELTIEFEKATKEEIDQEAFKLPASKALPIPGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT2</accession>
    <name>K0INT2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30010"/>
    <dbReference type="EnsemblBacteria" id="AFU59919">
        <property type="protein sequence ID" value="AFU59919"/>
        <property type="gene ID" value="Ngar_c30010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30010"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2973"/>
    <dbReference type="HOGENOM" id="CLU_018383_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3001-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="814" mass="89552" checksum="3DC8F559F540BE6F" modified="2012-11-28" version="1">MYTGYLKPFLIFLLVVLFFASLSTILFELALTRVFSIILWYDYAFMAISVAFFGLGIGSLVIHIQKDSAKWKSIYERKEQLSSRIIYFAVAYAISVPVFVFLISAIPPSTSNIHLFYLVSSVPFFFAGSVMALVFYAMPQKISKLYFADLVGAAAATLLLDPLMRGFGAEYVILLTAPMVAGSAIAGALALKGLPSGIAVITDRLKMLAGIVLAATLLVPIAGNASAFDAFEVRPGSNKGLYYQLKNPERFEHLSKEWNSFSRIDVTRETKVNSTLNNYDSTEDSRELAAIIIDADAGTPIFRWNGSQSDLLWMQKYMDYLPYEIDKVESTLVIGGGGGEDILVALAGGSEQVTVVELNPLIVSAAKRFADPAGSPYERDNVQLFIDDGRRFISSTEEKYDAIMIKLVDSWAAQLAGGYALSENYLYTTEAFQQYLRHLNEDGMLVMIRWNFELPRLMPLMADSLMKETGKSREEVSKHVMVVEDRPGLFFGRTDDAQTYYPVLVVVKPTPFTDAQIDLTREKAEQGRADIIMLSDEYIEPPYDKLFSSEGYNDYFAQVSNPKVPTDDSPFYFAREPVPQQMIVLLETVLGISAGLSVLLMWNARKKKARMDATSGSHVLFAVFIGLGFMILEITFIQKFLLLLGTPIMALTVILFSILLSSGIGAYLSGRLFGGRPYRAVFVSVPILAGMILFNFYFLQGIIDSSITMDLTARAALTVALLFPAGLLMGFQFPSLISMASLVKNKEDNTTLLWGVNVIASIIGTVLAATLAMIVGFSGNLLIGLGLYAGAAVSALFALLSIKRAQVAVMGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV2</accession>
    <name>K0INV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60019">
        <property type="protein sequence ID" value="AFU60019"/>
        <property type="gene ID" value="Ngar_c31030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3079"/>
    <dbReference type="HOGENOM" id="CLU_2911655_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3103-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6784" checksum="3E5A80F7FB9B530E" modified="2012-11-28" version="1">MRLAFGTFLGLPDPVKFMGDASYVDTRYRVDPPAALTAEVDCRIVGSNFALDWGAWEFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW4</accession>
    <name>K0INW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60079">
        <property type="protein sequence ID" value="AFU60079"/>
        <property type="gene ID" value="Ngar_c31630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31630"/>
    <dbReference type="HOGENOM" id="CLU_207595_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3163-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="6883" checksum="E91050DD341152B0" modified="2012-11-28" version="1">MPTEWATFVHNIVTQLTQENVALTYDLNNVKIAVPGSPNDNGAEKAQWVIDGSITVRGTRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW7</accession>
    <name>K0INW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60094">
        <property type="protein sequence ID" value="AFU60094"/>
        <property type="gene ID" value="Ngar_c31780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31780"/>
    <dbReference type="HOGENOM" id="CLU_121269_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3178-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="186" mass="20680" checksum="A6C53DF0C8938FEB" modified="2012-11-28" version="1">MAAASLALYFSLSLYVFPQLYLIEPRRPEAVITNVNLSASEVELGETFTISVAGTNRGEEADMQIVSVGFPNLTRSDSIEVLRHNFAQTPLRISIGTEVGSEYSGERMVNAQYPSIEASSRPWAGGGTYNIDLQVRPETEGTFVIFVKSIAFPHSWNRAHWPQEGVSDYQKEFVDVYQVQVVTTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY3</accession>
    <name>K0INY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32590"/>
    <dbReference type="EnsemblBacteria" id="AFU60174">
        <property type="protein sequence ID" value="AFU60174"/>
        <property type="gene ID" value="Ngar_c32590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32590"/>
    <dbReference type="HOGENOM" id="CLU_419582_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3259-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="653" mass="68461" checksum="4F9F6EA07F3FA891" modified="2012-11-28" version="1">MMPASAQSGVPVKNALVVVNGQEDLILQSIIATGGSPSNVRNALETAELLSAFTPHVSTDAFGRFELNESLDPGIYNVTVFVPGFVASSNNIVVVDGTSAAKNLTIFMQPSAMVSGRITDEQGRPIPGIVVAASSPHSANYDITMDDGVFVLDTGLKTGQYDIYAFKPGIDIAILQNLLNNTELGSLQNKVPILFKTQDAGYISHVSEVQLEQGKLTTLNVQLKNSHAISGRVTDSAGNAVPDVAVFAFDSNGIMVDTAAITDSDGRYTLDNDLAPGEYTIIIPSLFSKEYAPASAAVTLPAENNTVNFTLHKSGTISGRVVEPNGNPVADATIFAMPKGLHVDDTQLALFLAAGTATAKTDQDGRFTLDSGISSGTYVVTASFGSVPVSSLIEVQAGSLANIVLDFGETITIRGKVTDSSSGRPIENASVVPSFASVIPSAELFAAKTGPHGAYELIIPIKDNSTRSLFDEVTVSADGYKSATVPSSAATVIRLDKMPATKITGVVIAQKPLSPPVETVLVRKGTVVFEHEGMQYGVGLQTNSRIVDAAFDPPSRSINISLEGVQDASGRSEFSIPKEFMAGPFAVSLDGTSAAEGVSTAENQTHAMITIEHEHDLQKITIQGTTAVPEFPLPAAIAAAGLAAILAWKRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6W7</accession>
    <name>K0I6W7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57001">
        <property type="protein sequence ID" value="AFU57001"/>
        <property type="gene ID" value="Ngar_c00510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.58"/>
    <dbReference type="HOGENOM" id="CLU_170073_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-51-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8766" checksum="DCFE6EDFA250A17A" modified="2012-11-28" version="1">MAKPVMLSDEAYKALKAEKREGESFSDVILRKFQKGNAGAILAYYKKRGPNYDLANAVEEASRKLRKNFKTRKVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6X2</accession>
    <name>K0I6X2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00610"/>
    <dbReference type="EnsemblBacteria" id="AFU57011">
        <property type="protein sequence ID" value="AFU57011"/>
        <property type="gene ID" value="Ngar_c00610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00610"/>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OMA" id="PYDLQIA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-61-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14341" checksum="E5030E095F8876D2" modified="2012-11-28" version="1">MACFDSNFLIAWLQNDADALKKLEKLQHSPASTTMINAFELYKGIYRSKDKEKDIQKVKELLNSLELLTLDHESARMAGELDANMKSNTIGEADLLIASIVLTNGETLITRNTKHFERVPGLMVESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0I999</accession>
    <name>K0I999_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
            <ecNumber evidence="9">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rcsC</name>
        <name evidence="9" type="ordered locus">Ngar_c09690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09690"/>
    <dbReference type="EnsemblBacteria" id="AFU57911">
        <property type="protein sequence ID" value="AFU57911"/>
        <property type="gene ID" value="Ngar_c09690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09690"/>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="OMA" id="SAIQMNM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="365"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="632" mass="70604" checksum="80C229EEF48F0F8C" modified="2012-11-28" version="1">MAVAVILSASSFQYYSSNADRIAKMAADDIRLNAKIEAHDLSGIVENKLAKVVAVLNTLTASKNIQSLDVEGGKDLINQSQQSTADITEGYFWLDKDGTTVWNSIFATNQTLQEEYGKLNLNFRAYFIEPKETGQPYYSSVVESLDGIPRIYFSMPVLSDEDKSFKGVLVAAIKSTTLAEQVKQELFPGIESRVSLIDRNGVFMYNANTSWIGRTIYGEEVRTEIERSLSLDSTQISKIYNEILQGKSGSVDAVATSTQIMTTIAYQPVFLYNQQDRDDHHHLFTVIISIPHILAEDVVLLIDQQRIYSTVIVTGIGIIAIGIAIVVLMWNKKLREVVSKRTAELREANEQLKIREDLQKEFINIAAHELRTPIQPILGLADIKELQLQDDRKGGGEEIKITKDEMNIIIRNAKRLEKLSSDILEIARIESGNLRLNLQEFDLNNDVIMPLVKDLQNSMNGKDLKINLSIQGGKKMPVKGDVNRITQALWNLLDNALKFTDKGSISIIAKKENDYIVITVKDTGSGINSKILPRLFTRFATMSEKGTGIGLYISKKIVEAHGGKISGQNNEDGPGASFSISLPMYYNNNGDGDDDGGGKKEGEEEYLRFREKEEEQVRAKTWPDISSMRIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9T5</accession>
    <name>K0I9T5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation protein TolB signature-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58086">
        <property type="protein sequence ID" value="AFU58086"/>
        <property type="gene ID" value="Ngar_c11450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11450"/>
    <dbReference type="HOGENOM" id="CLU_2191106_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1143-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="11890" checksum="946F3B35B61D3DFB" modified="2012-11-28" version="1">MPSVGRKVEVGLHFINADGTNKVHLTDSSDGLIGCYVWSPDGTKIAYEANEDIFVVNVDGTNNIKNLANDGGTTDDFKPTWASNDKIIFESVVFDKDKRSFRASSFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA83</accession>
    <name>K0IA83_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12930"/>
    <dbReference type="EnsemblBacteria" id="AFU58231">
        <property type="protein sequence ID" value="AFU58231"/>
        <property type="gene ID" value="Ngar_c12930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1239"/>
    <dbReference type="HOGENOM" id="CLU_014051_4_1_2"/>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1291-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="695" mass="78120" checksum="BD068AFF286EF752" modified="2012-11-28" version="1">MQEEHASRGKPNKLAKETSPYLLQHAYNPVDWYSWGEEALERAKKEDKPIFLSVGYSACHWCHVMAHESFEDDEIAKIMNEHFINIKVDREERPDLDDIYQRVCQLATGTGGWPLSVFLTPDQKPFYVGTYFPKEGGHYNMPGFKTILLQLATAYKSKKQEIEAASGEFMDALAQTARDVALGAAGKASLERSILDEAAVGLLQMGDPIYGGFGQAPKFPNASNLMFLLRYYDISGMSCFKDFVAFTADKMAAGGIHDQLGGGFARYATDQKWLVPHFEKMLYDNALLAQLYSELYQITKAEKYLQITRKTLDFVIREMTHPEGGFYSAQDADSEGEEGKFYVWSKKEIASILGDQAATDIFCEHYGVTEGGNFEGKNILNVRVPVSSVGLRYGKTPEQTAQIIADASAKLFAAREKRVRPARDEKILTSWNGLMISGFAKGYGITGDQKYLQAAKDAVKFIETKIVTGDGRLLHTFKDGKSKLNAYLDDYAFYTGGLLDLFAIDSRQEYLDKAVKYTDFMLAHFWDEKEENLFFTSDDHEKLIVRTKSFYDLAIPSGNSVAASNLLRLYHYTQNNSYLDCAVKIMKASAKPAAENPFGFGQMLNTIYLYVKKPVEVTVITRNDHSSKMAEWLNQQFVPDGINAIVSTNELASLQKYAYFKGRVGDGETAFVCRNFTCSLPIKSQQELERQLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAK5</accession>
    <name>K0IAK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58351">
        <property type="protein sequence ID" value="AFU58351"/>
        <property type="gene ID" value="Ngar_c14150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14150"/>
    <dbReference type="HOGENOM" id="CLU_2191109_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1413-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12470" checksum="C4F10CD398CD0178" modified="2012-11-28" version="1">MPENEIVYLKYQNLEDMLKVIIYSAQSMLGVIPMLYHISHNGRHVLFIQTGTVGGVTVHYVIQNEKPAKKFIQLKRLSGEYTFIDNLGTDAQSLYVPILQLDKSTLAFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAN5</accession>
    <name>K0IAN5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-lysine/[LysW]-ornithine hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.130</ecNumber>
            <ecNumber evidence="2">3.5.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">lysK</name>
        <name evidence="4" type="ordered locus">Ngar_c14550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:48684"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="3.5.1.130"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:52676"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:13328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:136763"/>
            <dbReference type="EC" id="3.5.1.132"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family. LysK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.130" evidence="2"/>
    <dbReference type="EC" id="3.5.1.132" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14550"/>
    <dbReference type="EnsemblBacteria" id="AFU58391">
        <property type="protein sequence ID" value="AFU58391"/>
        <property type="gene ID" value="Ngar_c14550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1419"/>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_2"/>
    <dbReference type="OMA" id="HMDTVPG"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00039"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01120">
        <property type="entry name" value="LysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="148"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="363" mass="39519" checksum="7AC09E9013D154BB" modified="2012-11-28" version="1">MKKALELYTPSRSEAALANMIKDKCVNELGFEQVNIDNVGNIIATKGTGEPRILLCGHMDTVPGQVPVRIEDGHIYGRGASDAKAPLIAMLLAASEFPKQSGTVIFAGVVDEEGNATGVKHLVKSKLGVDYAVFGEPSGVENITVAYKGRLAVRLTCDVGDSAHASAPWLAKNSIEEMYDFWKAIKSEIERVGTAENKAKSISCSLTEITGGSSHNVTPQKCKITIDIRVPTITTCDNVLRIVDTVITKVALEKGVKATYRIEDKTEPFEADHASPLVRALLLAVLDVRNKRPTLLRKTGTGDMNVLGHSFKIPVITYGPGDPHASHTADERVNIDEYVASIEVYERALFHLSRLHHLKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAQ5</accession>
    <name>K0IAQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58416">
        <property type="protein sequence ID" value="AFU58416"/>
        <property type="gene ID" value="Ngar_c14800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14800"/>
    <dbReference type="HOGENOM" id="CLU_123156_0_0_2"/>
    <dbReference type="OMA" id="MITEWEF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1478-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="22944" checksum="63A9535FA23294FC" modified="2012-11-28" version="1">MLPIILLTTTTEGKAPKVTEAVKTVAIDVDSVLADVMLVWADEYSKRSGTRVTKKEIIRWDIPTVLPITPDTVYRYFSHVWKHRWREIPPTEPNIGDVTKRIHRKGYRISIITKRERPTVPYVAMWLDLHRVYADELLFIYDSVPKASYPFDVLIDDAPKNLVDITAPKSAILFNQPWNKDFEWPVRVNSLSEAEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAS5</accession>
    <name>K0IAS5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c15010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58436">
        <property type="protein sequence ID" value="AFU58436"/>
        <property type="gene ID" value="Ngar_c15010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15010"/>
    <dbReference type="HOGENOM" id="CLU_926276_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1499-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="2">
        <location>
            <begin position="140"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="300" mass="33394" checksum="A41D0C97B12EADD3" modified="2012-11-28" version="1">MLNAIMASMFNKMVSKEKRVGGSESEIHATGRAKEDDSATADAASIRPSEVFDSAKYNAMSDMAQGASLHAKNVESLIKTREAKTLESRQVDNESITAGRSNPDNMQTQITPMMVEERARTIRAANKEIQQMTSNTHSRNDKFVLYLNLMLSIENAAVERLHARIQQSPLAQIRQQLVHHLKETREQKERLISLITRLGGQPTGERAELPGYSPPKLLADALNASATAPEEQELKTLEADALIEHAEMIAYNTLIQMAVKMNIGEAMVPLRQSLQEEEEMVAWTRANLPSNFAQLWAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBT7</accession>
    <name>K0IBT7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c18030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58736">
        <property type="protein sequence ID" value="AFU58736"/>
        <property type="gene ID" value="Ngar_c18030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18030"/>
    <dbReference type="HOGENOM" id="CLU_490742_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1801-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="94"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="536" mass="60444" checksum="AD80A9BE48725F07" modified="2012-11-28" version="1">MHFEGTYMLQVTVAKGREPVIIFLAVVAIGLAAAFYLYFVVDKYSLLYYWDAVSHSVAARKFVDWGENPGLGQIGTVWMPLPHFLLLPFTLINALFTTGFAGTALSLPCLGLTSVYLYKIIKSLKMPSIAVIPSFAAFAGAMLYATNPNIMYLGITSMTEAPFMLFFVASAYYFQSWYQNGNRLRDLILCSIFLSFATLTKYEAWFLPIFLIIVAAVFMIRSKSQSPNKQKIFAILASVLSLSNIVFWLVWNQYHYGDALEFSNAQYYSASWYAQNRPFREILFLQPANVLSIYGVTAFAMYGPLLLGAGILGYWIFRKANVSGKKLVLLFLALPPIFTITSLLIGIGEMSYWFNSRFMVLLSPLIIVIACIFLANTNNNNNIKEDRRRIIIIGAIGVLFASQLAMPAFFTIITMNDAIGGYSVKENLLAIDTGEALKSLYDGNGKIMILTGSGLEHRVMITSGIPLANFDEIIEHSTWKASFKEPWSHDRWVVITEKPGTDALSTTQYWLDRMAELETHYRTVYENEYYKILVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC46</accession>
    <name>K0IC46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01660"/>
    <dbReference type="EnsemblBacteria" id="AFU57115">
        <property type="protein sequence ID" value="AFU57115"/>
        <property type="gene ID" value="Ngar_c01660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01660"/>
    <dbReference type="HOGENOM" id="CLU_1922865_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-166-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="15451" checksum="3F2EC0FDD379F8D7" modified="2012-11-28" version="1">MEGNWNENYKITIPAHKLYPYQWSWDSAFIAIGNSYLNVNRAITEFENLFSAQWKNGMLPQVVFYESSDSYWPEPEYYQIERSKDSPSHVMISDMTQLPVNAISCCYISMKMSEMLTSTKQRNSSRECFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC50</accession>
    <name>K0IC50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57120">
        <property type="protein sequence ID" value="AFU57120"/>
        <property type="gene ID" value="Ngar_c01710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01710"/>
    <dbReference type="HOGENOM" id="CLU_2875196_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-171-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7201" checksum="B7A0D627B220DD33" modified="2012-11-28" version="1">MATKDNNKEEQKVKVDGTEVKVKTPPPRKVRPVYYCQTCDTLFPSQLDLEEHMKIDHSKIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICC4</accession>
    <name>K0ICC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57195">
        <property type="protein sequence ID" value="AFU57195"/>
        <property type="gene ID" value="Ngar_c02470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02470"/>
    <dbReference type="HOGENOM" id="CLU_1998813_0_0_2"/>
    <dbReference type="OMA" id="NAANYER"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-247-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="14814" checksum="8BB4EB57AC5C8283" modified="2012-11-28" version="1">MHYVLRTDVVLLKPPKSQEIELRRLAEQSSLLWNAANYERRQAYFKHHKIPTYHEQCKTLKHSEYFKAIGTGKGQALLKKLQEAWNSFFALKRLQRQGKLPPNIQKVRIPSYWKNRITNRAQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICF4</accession>
    <name>K0ICF4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21250"/>
    <dbReference type="EnsemblBacteria" id="AFU59056">
        <property type="protein sequence ID" value="AFU59056"/>
        <property type="gene ID" value="Ngar_c21250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2108"/>
    <dbReference type="HOGENOM" id="CLU_062565_0_0_2"/>
    <dbReference type="OMA" id="YGVPLYA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2123-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009995">
        <property type="entry name" value="DUF1512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07431">
        <property type="entry name" value="DUF1512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016495">
        <property type="entry name" value="UCP016495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="39591" checksum="1FB0D2AD5C48FDD4" modified="2012-11-28" version="1">MWVYIISIAIIPFFMMYAQKFQSRVILGEISKSLVKLKTMKEGARKEAVDYIKTTVKTTTSPSSDPAAGVDRFLEYFAIMPVDLDPNGIVRKLDHIMRVRDDRLRAEVRKLCAGASDQEVSKIENILEAATALNMIYKIVRHFYLMGKRTTSMFVLVQLQMVMPLLLEEAEALQKAINAFKRGQPIGDGIGPMVVGKMMLGKEKKLAARETVYSEDEYKGRKLYLLKAEGPAGTVGRPGEAITRLAGDMGIKIDAIIMIDAALKLEGERTGEVAEGIGAAIGGIGVEKYQIEEVATRLDIPVYAVIVKQSVQDAITIMRKEIADAFDKVTNTVYSVIEDKTSEGQSVMVIGVGNTMGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICI4</accession>
    <name>K0ICI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03220</name>
        <name evidence="3" type="ordered locus">Ngar_c03520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Enrichment culture Ga9.2</strain>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57270">
        <property type="protein sequence ID" value="AFU57270"/>
        <property type="gene ID" value="Ngar_c03220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57300">
        <property type="protein sequence ID" value="AFU57300"/>
        <property type="gene ID" value="Ngar_c03520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03220"/>
    <dbReference type="KEGG" id="nga:Ngar_c03520"/>
    <dbReference type="HOGENOM" id="CLU_1329510_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-322-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="22350" checksum="7BB7569FCB743648" modified="2012-11-28" version="1">MFEALFLQQAPTGESLTAIILGAIATLIPTISIILKQWSNGKFTSQQLAEKGLELQGAIASEQTQRRASERLSCIVAQLIIANNDGRIDQREFDHIIGLARAALVETSREAGLDITEIVTAAEKLLAKPGSGQPIDIKSIPYYSPTGTPMLKPEELLQGFDLDAIRQAPAPTQIPGADKMNLPQFQAAFRVWSEAHGFKPMTPVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICL2</accession>
    <name>K0ICL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative SirA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21760"/>
    <dbReference type="EnsemblBacteria" id="AFU59106">
        <property type="protein sequence ID" value="AFU59106"/>
        <property type="gene ID" value="Ngar_c21760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21760"/>
    <dbReference type="HOGENOM" id="CLU_165255_1_2_2"/>
    <dbReference type="OMA" id="CPEPVFR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2174-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9005" checksum="890B67F7E5426F9E" modified="2012-11-28" version="1">MSASPTTKSIDVRGLYCPEPVFRTKMEIERLKIGDTLKVIADDPESEEDISRWVNRNGHQLVSLTKSDKDLEFVIKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICZ1</accession>
    <name>K0ICZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59236">
        <property type="protein sequence ID" value="AFU59236"/>
        <property type="gene ID" value="Ngar_c23100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23100"/>
    <dbReference type="HOGENOM" id="CLU_1745603_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2308-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="15963" checksum="D57091D71F1B8C83" modified="2012-11-28" version="1">MHKFPSLASPEVLEGSIIIDETSLEPNLSIAAEMVDLPARQQLLLSLAGNPPDVPLQARITGPNGETLVLYNVTNTLFSSTTVTVSTGNHTLEIKNAGSRPVTVSGALLISPIGQQDDGSIENDDVLHETRLKLQLFAGTLDWIITMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID13</accession>
    <name>K0ID13_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nirK1</name>
        <name evidence="8" type="ordered locus">Ngar_c23400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23400"/>
    <dbReference type="EnsemblBacteria" id="AFU59266">
        <property type="protein sequence ID" value="AFU59266"/>
        <property type="gene ID" value="Ngar_c23400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23400"/>
    <dbReference type="HOGENOM" id="CLU_031740_1_1_2"/>
    <dbReference type="OMA" id="HAMDFHA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="66"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="357" mass="38158" checksum="7434D269D5B39062" modified="2012-11-28" version="1">MNKAIVAGLAAGVLVVGLIFSPLFTGFPLSTAQAQGTGNTKHFTLIADEMELQVAPSNPLHPGGIMYKAMVFNGTIPGPVISVHQGDTVEITLRNEGNVIHSLDFHAGIGPSKALSGNVAAGESKTWTFDAVNAGAFLYHCGADGLNGVWEHIANGMYGGVVIHPHNEKPAKEFYVSFGEIYNSADKGPFVGTNGTVGSFDLVKLWNDSPDLILTNGMAHKYVPEIGAASKIPLNPDAEVFMVKPGELTRWYIVNPGPNDYVAFHFIAGQMDVRDGSIKNRYGTQLKNDETWTIPPGSATVIEAVFPEEGVYVGVDHNMSHVLKGGAFAVVADDASTDNDHPEGTYVMSMEETMMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID41</accession>
    <name>K0ID41_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c06370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06370"/>
    <dbReference type="EnsemblBacteria" id="AFU57580">
        <property type="protein sequence ID" value="AFU57580"/>
        <property type="gene ID" value="Ngar_c06370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06370"/>
    <dbReference type="HOGENOM" id="CLU_081251_3_4_2"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-635-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20134" checksum="E6EDA373FE13494D" modified="2012-11-28" version="1">MRTFIAVDASVAGAIAKLQNEIMSAAGWSTRDIKPVETQNFHFTLIFLGEKSDSDVGRIKSKLAEVQFEPFTLTYTGVGAFPKPALARVVWVGVDQEGGQKLTALANDVIAKMGELGFSADKPFSPHMTLFRARSRPVQINNIAAKYLGRTFGSDLIERVHLKKSDLSPSGPIYSNIYTVEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDJ7</accession>
    <name>K0IDJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57740">
        <property type="protein sequence ID" value="AFU57740"/>
        <property type="gene ID" value="Ngar_c07980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07980"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-796-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="13717" checksum="859BD841E637DDDF" modified="2012-11-28" version="1">MKAWHLEHVEKTIVRFIKGLSPDASSFEKRNYKKYGTISYCIKQIEYDMKHGVDKTEVMEILRKIRLAANYADLRQNAEAVERLERLEDQLSGAQKVEESLSWYNNAYREKSGRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDK5</accession>
    <name>K0IDK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25590"/>
    <dbReference type="EnsemblBacteria" id="AFU59481">
        <property type="protein sequence ID" value="AFU59481"/>
        <property type="gene ID" value="Ngar_c25590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2536"/>
    <dbReference type="HOGENOM" id="CLU_076368_1_1_2"/>
    <dbReference type="OMA" id="IDTDVMV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2558-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="24999" checksum="F4AB0A3B11552E70" modified="2012-11-28" version="1">MIARDCHYMKIGIVGGTGGMGEGFALRWCKKHDVIVGSRDAQKAKEAAENYSKIAREAFGTITGSITGDDNIALGKDVDVLILSIPYEFIDDTCGRLVGKIRDDCVVVSPIVPMTRTDAGFVYIPLEQGKKQAAEMVADKLPPRSRVVSAFHTISEVKLKNVNQGLDADTFICGDDQGAIAKLTELVSEISGLRPVYLGPLSLTYQAEILTPMLLNAAKKNKMKNPSVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDZ5</accession>
    <name>K0IDZ5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl15e</name>
        <name evidence="5" type="ordered locus">Ngar_c26750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26750"/>
    <dbReference type="EnsemblBacteria" id="AFU59596">
        <property type="protein sequence ID" value="AFU59596"/>
        <property type="gene ID" value="Ngar_c26750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26750"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2650"/>
    <dbReference type="HOGENOM" id="CLU_080796_1_0_2"/>
    <dbReference type="OMA" id="KYMQELY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_L15e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="16374" checksum="785B17D112A1DE70" modified="2012-11-28" version="1">MWKENSDELKSKAIAWRTEPTIHRIERPSRLDRARRLGYKAKQGIVVVRARVGRGGMRKQRPVAGRRPKHIGVVHIKQGINMRKVAERRVSEKFPNLEVLGSYYLYKDGMNIWYEVVLADPSHPAISKDREMRGKLKAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE54</accession>
    <name>K0IE54_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleoside-triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01480"/>
    <dbReference type="EnsemblBacteria" id="AFU57098">
        <property type="protein sequence ID" value="AFU57098"/>
        <property type="gene ID" value="Ngar_c01480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.148"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_2"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-148-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20429" checksum="8540219AEFA3C5E7" modified="2012-11-28" version="1">MRAVTFASTNQNKYREVQSILSAYGISVDFAQVNPVEIQSDSLEEIAREKAKSAFSQVGRAVIVEDDGLFIDMLKGFPGQYSSHAFKTLGNAGIMKLLEGSADRSASFRSLIAFYDGKSLSISEGRVDGRISDRIAEGGWGYDPIFVPDGTDLTFAELKEKKNEYSHRKKALDNFAQWYKHTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEE4</accession>
    <name>K0IEE4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59701">
        <property type="protein sequence ID" value="AFU59701"/>
        <property type="gene ID" value="Ngar_c27800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27800"/>
    <dbReference type="HOGENOM" id="CLU_2581212_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2780-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9988" checksum="1179B981C751DB8B" modified="2012-11-28" version="1">MALMEEESEWKGFRKCLERKERKILDGMFDKSRLYIPSCMYSANPIVIYPIFLSMLLHHYRELSEIVNRVEQLTGERYDTIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEV3</accession>
    <name>K0IEV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58295">
        <property type="protein sequence ID" value="AFU58295"/>
        <property type="gene ID" value="Ngar_c13570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13570"/>
    <dbReference type="HOGENOM" id="CLU_770780_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1355-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="359" mass="41124" checksum="364CAC822CBA2719" modified="2012-11-28" version="1">MMAERLHSENVTNQEWLQHSGRCKRLAAFALEKGTAGFTRRDIVREGISKNENAAKVMLKRAVDAKIIKVNEEDHSRRRRYYHASVIADVMADFYTQNVTERPTGPARRAMQALELATYDWIESNILQMLPGSPQYIHNMHFRLKLSDKWLASGLYSSLSGEPAKGNRAKRFEKYLSGHFVEGQNRPAAGHLVEFLIYPNGTVVINTSTSRAPHRIETPEDLDALNQWLGRIEQALADVLSCRHSDMVPPVREWILTRCDLNIDIEVPHELQLYGPNLQWKYYGHLFRLYVKSMGDRTVARPEISPSPKEPVTESLAKVFTLAGHEKRLTLHDDQIMEMKGQILSLQKQVAELERRAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF06</accession>
    <name>K0IF06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57383">
        <property type="protein sequence ID" value="AFU57383"/>
        <property type="gene ID" value="Ngar_c04360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04360"/>
    <dbReference type="HOGENOM" id="CLU_3057242_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-435-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5939" checksum="DC0D52BDFFF571F1" modified="2012-11-28" version="1">MHYFLVENKPLSVEIIVSNFGGSYPHGKVHMDTIDMLESKGYSFGKIKSVLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF68</accession>
    <name>K0IF68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh</name>
        <name evidence="4" type="ordered locus">Ngar_c30950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30950"/>
    <dbReference type="EnsemblBacteria" id="AFU60011">
        <property type="protein sequence ID" value="AFU60011"/>
        <property type="gene ID" value="Ngar_c30950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3068"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_2"/>
    <dbReference type="OMA" id="WAKAQSF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="374" mass="41331" checksum="F21A9799A6DE7810" modified="2012-11-28" version="1">MKAVVYHGPMDVRVDDKPKPKIEHQEDIVLKVTRTTICGSDLHLYHGNVKGMEPGQTLGHEFAGVVEQVGDSVDEVKAGDRVVIPFNISCGRCWFCRHQFWSQCDRSNPKGELGAVYGYGQMMGGYDGGQAEYVRVPYANTDPLKIPDNVSDDQALFLTDVLATGYFGADIANVQPGDDVAVFGAGPVGYFSAMSSLLRGAARVFVVDHWPTRLDKVAKIGAEPINFDKEDPVERIKKEAMGKGAVCIDAVGYEAVGHHSHDASSNPAYIPQNSLQVINWIVQVAHKFSTVGIPGVYMTEFANFPFGQFFQRELQIKMGQCPVKLYNEQLLHLIEVGRIDPTQLISHRMKLDEAKRAYDIFDKKGEATKIVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA1</accession>
    <name>K0IFA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate--CoA ligase (ADP-forming) beta subunit</fullName>
            <ecNumber evidence="8">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sucC</name>
        <name evidence="8" type="ordered locus">Ngar_c15460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.5" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15460"/>
    <dbReference type="EnsemblBacteria" id="AFU58480">
        <property type="protein sequence ID" value="AFU58480"/>
        <property type="gene ID" value="Ngar_c15460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15460"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1513"/>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_2"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="368" mass="40025" checksum="23E6CFAEF8F0540E" modified="2012-11-28" version="1">MKLLEYQGKELFDQYGIRIPRSHLAHTLLDAREGGRKLGYPLVLKSQLTVGGRGKAGAIVKCKSESELESRFNELLHKEVKGELPRGILLEEMADIKKELYLSLFLNRSKRCYSLISSSEGGVEIESARNKVMVDVPIDGLTAHTAEETASKLGLDGKTVVSFVDFTTKLSRLVSEKEAELAEINPVAILGDGSLMALDAKVIIDDNSMFRHPELKKYEHVSELERQAEVSGFSLVELDGNIAIIGNGAGLVMSTLDMVSDAGGKAGAFLDFGGRATTETIYEALKVISKIKQIDAILVNLFGGIVRTNLVAQAILDAYKNNLITVPVFARISGAESEKAREMLNGSRAKLYNTVEEAIQAAVAAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFI0</accession>
    <name>K0IFI0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16370"/>
    <dbReference type="EnsemblBacteria" id="AFU58570">
        <property type="protein sequence ID" value="AFU58570"/>
        <property type="gene ID" value="Ngar_c16370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16370"/>
    <dbReference type="HOGENOM" id="CLU_1340764_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1635-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="22518" checksum="7217BFA4E4B49276" modified="2012-11-28" version="1">MEERFRTDFGKVRIHTGLQAARLSSNLNAIAFTVGNSIMFAEGKYSPDSQAGRQLLAHKLTHVVQQQGAELHSIQRAKTDTTNSCSGLADSMSDVNSRINKALANAHKAAGASLPVQMWHRNFMQSWLKIPLRAQGEDRAMGRGIGRIKSAPSGPKFNQVCRRDISSVEQSLISDTQSDNACERSLYWKRQVGSLFATGLRVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG11</accession>
    <name>K0IG11_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcription regulator, containing CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c08010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08010"/>
    <dbReference type="EnsemblBacteria" id="AFU57743">
        <property type="protein sequence ID" value="AFU57743"/>
        <property type="gene ID" value="Ngar_c08010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08010"/>
    <dbReference type="HOGENOM" id="CLU_116133_0_0_2"/>
    <dbReference type="OMA" id="HYKAVMI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-799-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="22495" checksum="0B6A6663E44CA08C" modified="2012-11-28" version="1">MPVQLPTLASIRKRRLALGMTQQQFAQVCRLSQSMIAKIENSRTDPSYSTAIKIFETLERLEAQEINRIPRLITAKDIMTKKLISAAPTDLLFKAALVMLENNISQMPVLSREAATDIVVGGLTERLLLTAWNGDSNFKGKKVSDIMSEPFPIIGQDTTISTIRNILTDEPAVLVSDSASKRIVGIITKQDLIKVTARVRGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG12</accession>
    <name>K0IG12_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">purA</name>
        <name evidence="8" type="ordered locus">Ngar_c34310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34310"/>
    <dbReference type="EnsemblBacteria" id="AFU60346">
        <property type="protein sequence ID" value="AFU60346"/>
        <property type="gene ID" value="Ngar_c34310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34310"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3428"/>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_2"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="334" mass="36125" checksum="4633F2DD89A190A3" modified="2012-11-28" version="1">MPCLVTVGGFYGDEGKGKIIAYLARKDNPSIAVRGGVGPNAGHTFTFEGKEYKVRMLPSAALNPTTRLLIGAGVLVNPQVLLKEIAMFQSDDRTFVDAQCGIIEQAHIDRDKGEDHLKSKVGTTGTGTGPANADRALRTLKLAKDIPELSLYIEDVSNSVNCALENNENVLVEGTQGTYLSLFHGGYPYVTSKDVTASGICSDIGIGPKRVDDVLVVFKAYVTRVGGGPLQNELSEDEAKKRGWLEFGSVTGRQRRASPFDMDLAKKAIRINSATQLAVTKMDVLYPQCASVRDYAKLPAEAKKFIENIEGETGLKVTLIGTGPELYDVIDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM3</accession>
    <name>K0IGM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00070"/>
    <dbReference type="EnsemblBacteria" id="AFU56957">
        <property type="protein sequence ID" value="AFU56957"/>
        <property type="gene ID" value="Ngar_c00070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.8"/>
    <dbReference type="HOGENOM" id="CLU_057456_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-7-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="300" mass="33478" checksum="1DD7C943EF5FC071" modified="2012-11-28" version="1">MAESQQQTIINLYNSGIPPDIIALQLDISQEEVDRVIASAEKSRPTETTTLASFYLDAVVDLDKAIKMAQERVWKALKVESRFDLSTEETQEILSKLAKSKATFVILHIDLVGSTRLSSSLPADRLAAIIQAFTQEMSITIAAYGGYVLKYVGDAILAFFLANDDTYLPCVNAVNCARSMIKIIRDGINPILNQYDYPEISVRVGIDLGENVVVQYGWDTHTVDGKKVRSPHYDILGYTINIATKMTTLAKPDQIVIGQMVYDVLDDRQKSTFHPLRISPEVWNYVSDYSHGIYPLYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN5</accession>
    <name>K0IGN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin</fullName>
            <ecNumber evidence="7">3.4.21.62</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apr</name>
        <name evidence="7" type="ordered locus">Ngar_c10560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10560"/>
    <dbReference type="EnsemblBacteria" id="AFU57998">
        <property type="protein sequence ID" value="AFU57998"/>
        <property type="gene ID" value="Ngar_c10560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10560"/>
    <dbReference type="HOGENOM" id="CLU_011263_15_7_2"/>
    <dbReference type="OMA" id="MTYPATH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="118"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="417" mass="44332" checksum="A47B067162534082" modified="2012-11-28" version="1">MYYIAFFLITLILLAPSFTTYVSQNAAVIVSFADGKYNPAIVVTAGGRIFEEFKNMGMLYAIVSQRALTSLEQNPAIEFVESDGRFEIAEEASTSEYAESWALKDISAEPAHLSNYTGRGVKIAVLDTGIDYNHPELAPNYKGGYDFINNDNDPMDDNGHGTHVAGILAAARDGRGIVGVAPDAEIYAIKVSDERGKGSFSGLVKGIGWSIENGIDIVTMSITGNSGSKALAKAVESAYNEYGLVLVAAVGNGNGNVLYPAAYEQVIGVGSVTEDNELSSFSMTGSEVELVAPGSRIKSAAIGGGYRLSSGTSMATPFVTGAIALLFGSDEKAWGNTGMVDGDGAWTNDEIRNVLRYTAKDLGDKGKDDLFGYGLLNLDFLRGQPSIITPSVPETEDKPIVLKLAWFTFKVSLQPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS8</accession>
    <name>K0IGS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57032">
        <property type="protein sequence ID" value="AFU57032"/>
        <property type="gene ID" value="Ngar_c00820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00820"/>
    <dbReference type="HOGENOM" id="CLU_2340265_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-82-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10671" checksum="5A772B3D751314D5" modified="2012-11-28" version="1">MKASHPLSPTKVLQQLNSRPFVDTPVSELGKVEERLGISMGAYLLPCKAETGVRPDTLPVERREFTPGEIRSSVTEPGKVLLNHVTVEGEANGFSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGU3</accession>
    <name>K0IGU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c21350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21350"/>
    <dbReference type="EnsemblBacteria" id="AFU59065">
        <property type="protein sequence ID" value="AFU59065"/>
        <property type="gene ID" value="Ngar_c21350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21350"/>
    <dbReference type="HOGENOM" id="CLU_037162_14_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2133-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="16271" checksum="975B59A8BC7E5117" modified="2012-11-28" version="1">MALEQSIGAVIKYRNSLEDGGASSEFLLLKNRRGFWGFPQGHKEKGESEIQTLIREVLEETGIKELDIHSYIGKINYSYFKGDGMKSEKEVTFYFATTPTREVRISEEHADFRWVTLADALNMLDHAKLKLILSKGHRKGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX3</accession>
    <name>K0IGX3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="2">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoJ</name>
        <name evidence="2" type="ordered locus">Ngar_c11570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11570"/>
    <dbReference type="EnsemblBacteria" id="AFU58098">
        <property type="protein sequence ID" value="AFU58098"/>
        <property type="gene ID" value="Ngar_c11570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11570"/>
    <dbReference type="HOGENOM" id="CLU_085957_2_2_2"/>
    <dbReference type="OMA" id="WPALILM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="18384" checksum="B9CACDF6AB2F5A25" modified="2012-11-28" version="1">MADPVFIAVAVLTVGTAIIALEARELIYGAVALAISMLGIAGFFLLLDAPFVAMFQIAVYVGAVAVLIIFTVMLVRTQALFTTKEDKKRKGAGIALMLIIMASLGALLLISGLNGQFGNFGGPQNVDFTQIGELMLTYYAPALIILGLTLAGSVIAALALARREDVEQQHERAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGY3</accession>
    <name>K0IGY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 4-oxalocrotonate tautomerase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57077">
        <property type="protein sequence ID" value="AFU57077"/>
        <property type="gene ID" value="Ngar_c01270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01270"/>
    <dbReference type="HOGENOM" id="CLU_148073_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-127-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018191">
        <property type="entry name" value="Tautomerase_Pseudo-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00013">
        <property type="entry name" value="taut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via imino nitrogen" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR618191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="7101" checksum="10EE170271A1C4FA" modified="2012-11-28" version="1">MPVIQITMSQGRTVEQKRELVKVLTKETARILNTKEESIRVLIYEVSKENWGNAGVLGLDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH60</accession>
    <name>K0IH60_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylation subunit</fullName>
            <ecNumber evidence="7">6.3.4.14</ecNumber>
            <ecNumber evidence="7">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">accC</name>
        <name evidence="7" type="ordered locus">Ngar_c01880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="7"/>
    <dbReference type="EC" id="6.4.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01880"/>
    <dbReference type="EnsemblBacteria" id="AFU57137">
        <property type="protein sequence ID" value="AFU57137"/>
        <property type="gene ID" value="Ngar_c01880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.188"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_2"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="6">
        <location>
            <begin position="4"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="123"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="503" mass="55847" checksum="C64222A2A9271BA3" modified="2012-11-28" version="1">MSKKISSILIANRGEIALRVIRACKELGIKSIAIYSDEDVRAVHVKRADEAYHIGPAAPAQSYLNMAKIVETAKAAGADAIHPGYGFLSENENFPEMCEKNGMIFIGPTAKAMEITGDKMKCKEVMKKAKVPTVPGSDGIIEDVEKAADIAHKAGYPVLLKSAFGGGGRGIRLANNEKQLRQEFEMASAESRAAFGKAALFVEKYLQKIRHIEFQLIRDSHGNGRHLFERECSIQRRHQKLIEMSPSPVVDQKTRERIGEIAVRAAAAVDYLNAGTAEFLRDPEGNFYFIEINSRLQVEHPVTELVTGLDLVKLQIAIAQGEEIPFKQEDLKMNGCAIECRINAEDPFYEFAPSTGIVPNCNIPYGPGIRVDTYLYPGCNVSGYYDSLTAKLLAWGKNFEEARVRMRNALDEFTIEGINTTIPLYKTIIDEPNFIKGELSTDYLERFKIFDRMNEQAKERAKEKARAAVAAVLLQSEFVKKVGAAQTAATAAKSSKWKMMRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH81</accession>
    <name>K0IH81_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="6">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c12730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12730"/>
    <dbReference type="EnsemblBacteria" id="AFU58213">
        <property type="protein sequence ID" value="AFU58213"/>
        <property type="gene ID" value="Ngar_c12730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12730"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1221"/>
    <dbReference type="HOGENOM" id="CLU_018697_4_2_2"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1271-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="138"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="435" mass="48230" checksum="59135166615D75E2" modified="2012-11-28" version="1">MLRRSKPKVWVEAYGCSASMADSEMISGLLKGAGYEIASKQSEGALNLIVTCSVKDTTEHRMVSRIKAMSKSGKPLVVAGCLPKADRAKVESLNSLASLLGPHSIEKAVDVVGSALAGGRLVALEDSVADKVNIPRVRLNPMVSIVEIASGCMSECTFCQTKIAKGWLRSYRIGDIMRQIKADINAGCKEVWLASTDNGCYGKDMGTDLVELLRACCSIEGDFKIRLGMMNPMYVPEMLNRMVDVFYENEKLFRFLHIPVESGSDRVLRKMKRGHTTKTFLDAVQAFRSKIPEMTISTDVIVGFPSETEDDFKETLDLVERAEPDIVNISRYSARPGTEAAKWKGMRVSSQVAKERSERLHVLAKKVAKKRNSLWQGWQGEIIIDEMGKVVQGRNYAYKPVVVLSSNLGKVSLGDRKRVQVYDFSNFSLKARIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHL5</accession>
    <name>K0IHL5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RadB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radA3</name>
        <name evidence="8" type="ordered locus">Ngar_c25220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RecA-like protein family. RadB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25220"/>
    <dbReference type="EnsemblBacteria" id="AFU59445">
        <property type="protein sequence ID" value="AFU59445"/>
        <property type="gene ID" value="Ngar_c25220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2500"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_2"/>
    <dbReference type="OMA" id="GGINDPD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011939">
        <property type="entry name" value="DNA_repair_and_recomb_RadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003336">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="6">
        <location>
            <begin position="37"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="7">
        <location>
            <begin position="213"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="30758" checksum="071775F8677D41E5" modified="2012-11-28" version="1">MEMDESVEICNKARVMLEELGVIDKSFVTATSLYSRRRDRISTGSKSFDDLLGGGLETKAVTEVYGEFGTGKTQLCHTLCVMVQQSRLAGGLDAKALYIDTENTFRPERIVSIAEARGFDPRKSLENVIVAKAYNSAHQELIIEEAGAVIEDNSIRLIVVDSAVAHYRAEFLGRATLSERQQRLNKFMHILVRIAETYEVAVVLTNQIQASPDAYFGDTVRPTGGNVVAHTSTYRIHLKRSGKNRIARMVDSPYHAEREILFTLTDRGISDVNEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II10</accession>
    <name>K0II10_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57602">
        <property type="protein sequence ID" value="AFU57602"/>
        <property type="gene ID" value="Ngar_c06590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06590"/>
    <dbReference type="HOGENOM" id="CLU_2629845_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-657-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="9445" checksum="F37C3BEF9AD1FB38" modified="2012-11-28" version="1">MEFKAIFRDYFRYRGCNARRQDGLDKKEKRRWSVPEDEVFRAVLKEHLECIGKRDRKRYEQLVKQIQETGGNAFFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0II45</accession>
    <name>K0II45_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hemB2</name>
        <name evidence="12" type="ordered locus">Ngar_c26840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26840"/>
    <dbReference type="EnsemblBacteria" id="AFU59605">
        <property type="protein sequence ID" value="AFU59605"/>
        <property type="gene ID" value="Ngar_c26840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26840"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2659"/>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU59605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="341" mass="37378" checksum="BC0B1DF757125D49" modified="2012-11-28" version="1">MNFADDSSSTEKHIFIAARQAMTLQQLQRDNEQRYREIFAAAGLRRSHLIFPVFVSDRPGMIESMPGMTVTPIEKITQHVQTIVDSGILSLIVFGIPKSRDRIGSSAFDRKGVVQRAVRAIKSSFGSSVNVVTDICVCQYNLSGHCGIVASGNKRVDNDATLQILAQVAASHAEAGADVVAPSSMMDGQVRAIKSALVGFFTKTMILSYSAKHASSLYTPFRSAAFAKMKPRLDKSSYQVSYANPRQVLLEIETDISEGADIVMIKPALAYLDLVRMVKDRFCGHPVAVQNVSGEYAMIKAAAMHNLIDEEEWKVCSIASIKRAGADRIISYFALDVSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0II79</accession>
    <name>K0II79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c27290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27290"/>
    <dbReference type="EnsemblBacteria" id="AFU59650">
        <property type="protein sequence ID" value="AFU59650"/>
        <property type="gene ID" value="Ngar_c27290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27290"/>
    <dbReference type="HOGENOM" id="CLU_084115_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2729-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="70"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="17311" checksum="F53B76655EA89D50" modified="2012-11-28" version="1">MTNENSNNTDKRKGQESRRRAIIAALVAGVSVAVFTGIIINTTLPRNTFALDVIHPPQSVTVTIPAGASLADNNVNFTPKDITVVLGVNNTVVWVNENVNPERVIGQDEDMPGGFGKIRTLIEPEGGTFAFTFTEEGTYNYLSAAHPWLQGTVTVKKADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA8</accession>
    <name>K0IIA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative archaeal preflagellin peptidase FlaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flaK2</name>
        <name evidence="3" type="ordered locus">Ngar_c08050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08050"/>
    <dbReference type="EnsemblBacteria" id="AFU57747">
        <property type="protein sequence ID" value="AFU57747"/>
        <property type="gene ID" value="Ngar_c08050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08050"/>
    <dbReference type="HOGENOM" id="CLU_1127120_0_0_2"/>
    <dbReference type="OMA" id="EEIWVTP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009655">
        <property type="entry name" value="Preflagellin_peptidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06847">
        <property type="entry name" value="Arc_PepC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Arc_PepC_II" evidence="2">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="299" mass="32356" checksum="08B0F1002C8634E1" modified="2012-11-28" version="1">MKVSLNHSEVELVFLTISKRNADMHEIISTDTHSFITTSRQAPHCQLTMITGIDFELVRILLAAGMLGSASFFDIRRREVSDMLWVFFGITALAVYALEFAYGGAFDLLNTSVPILIAAVVSFGIYKSGLFGGADALALTTLAAILPTFSGGIAERVLLPAGSAFLVHPIAPLIVLSNAVILSLSLIGFNLASNAAYASKNPGKLFEGLEHESTGKKILAVTVGYKTGSKPGYAFPIEQLVDGRRQFSFALKNAETTEYETRRDVWVTRGTPFLAFMLAGFVSMLFVGDIAAIIMRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID0</accession>
    <name>K0IID0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cobalamin (Vitamin B12) biosynthesis CbiX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c18000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18000"/>
    <dbReference type="EnsemblBacteria" id="AFU58733">
        <property type="protein sequence ID" value="AFU58733"/>
        <property type="gene ID" value="Ngar_c18000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18000"/>
    <dbReference type="HOGENOM" id="CLU_1109476_0_0_2"/>
    <dbReference type="OMA" id="VDYCFLE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1798-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="252" mass="28359" checksum="F08A6531D9B57EE5" modified="2012-11-28" version="1">MKKALLIVDRGSREPDVRQELQEICSIAKRRAGYDYADYCFLEVLPPFIGEGISKCVASGAGFVTVMPYFLYPGMKLKDTVKQSAKIGKDRKLQMAITKPLSYHPMMAQLIVDRISELKKDRGITYPDKECDVVLIGHGSSDKNARDAFIHAANMIRPHYRSVHFCFLELDHPNIEEGIGQAIAGNPKVILMMPYFLHRGAHIKTDVVKDVNAALDKHGFTSAFMARHLGVDEKLVDLVIERAREVEKRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE0</accession>
    <name>K0IIE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08600"/>
    <dbReference type="EnsemblBacteria" id="AFU57802">
        <property type="protein sequence ID" value="AFU57802"/>
        <property type="gene ID" value="Ngar_c08600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08600"/>
    <dbReference type="HOGENOM" id="CLU_153620_1_0_2"/>
    <dbReference type="OMA" id="DDYGAVY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-858-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15490" checksum="6F72D2A877477D31" modified="2012-11-28" version="1">MHLLPLSCLGSISFFQFSGLLGYLRVLASGRPSSGGYVDPRFKRVLWYLIGSTKGGVNRAKIIELLNSRPANPNQIANELKLDYKTVLHHLKVLSDNGLIITDNKESYGAAYFLTPLMENNYQSFVEILAKIKRSSGNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE1</accession>
    <name>K0IIE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58763">
        <property type="protein sequence ID" value="AFU58763"/>
        <property type="gene ID" value="Ngar_c18300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18300"/>
    <dbReference type="HOGENOM" id="CLU_2433962_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1828-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="9650" checksum="F87C7D39A68DCEEA" modified="2012-11-28" version="1">MNKKTMFILMGAGLVVSGIVTIILIYQGLSVGDVLVYQPLASETAGEMNKFNLEEIHSVSLAKHDHVLLTMLVDSQPAVVPEGIGMSPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH5</accession>
    <name>K0IIH5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57862">
        <property type="protein sequence ID" value="AFU57862"/>
        <property type="gene ID" value="Ngar_c09200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09200"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.880"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="YNACATG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-918-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="2">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="1">
        <location>
            <begin position="191"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="308" mass="35891" checksum="115F17D2DF8A8CC3" modified="2012-11-28" version="1">MVTTTTTRKRTYKFRLYPTKQQEILLDNTIETCRHLYNDSLGERSTDWDVGFYEQKQILTLRKQDSKYLKQVHSQVLQDVLLRLDKAYQAFFKKLARYPKFKRKGKYNSFTYPQYNNGWKIIRDNNKLVLSCIGAIKIKMHRSPVGTLKSCTIVRDVDQWYACITAAVVDVVDDDCDGIGIVTSTSKYDLSKPVGVDVGLINWLTLSDGNKIQNPLNFEAQARKIRQLQRNLARKQKGSKNREKARIALAKAWRQVRRCRDDFVHKTSRTIADQGYTFVVFEKLNIKNMVKNHRLAQAIMDAAWVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH8</accession>
    <name>K0IIH8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative adenylate cyclase</fullName>
            <ecNumber evidence="1">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19110"/>
    <dbReference type="EnsemblBacteria" id="AFU58843">
        <property type="protein sequence ID" value="AFU58843"/>
        <property type="gene ID" value="Ngar_c19110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19110"/>
    <dbReference type="HOGENOM" id="CLU_2299430_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1909-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="10799" checksum="E17C8FC1D139BDCE" modified="2012-11-28" version="1">MKFKNVLDCGLTMGIASIMLNAKMLSEKLPPIQYRISADYGEVSVARSASSQSEDLFGSAMNICAKINSKAKPNGLVIGEALFDKGMNMSLSHLKRDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ1</accession>
    <name>K0IIJ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6036 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57892">
        <property type="protein sequence ID" value="AFU57892"/>
        <property type="gene ID" value="Ngar_c09500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09500"/>
    <dbReference type="HOGENOM" id="CLU_1507432_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-948-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045792">
        <property type="entry name" value="DUF6036"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19502">
        <property type="entry name" value="DUF6036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6036" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="20173" checksum="047FF63EA680E20B" modified="2012-11-28" version="1">MPLDKSGLLGLLEAVDDELTKKITLVAAGGTAMTLLDLKPSTIDIDFTGPHEDIAEFNRVQKSIPHGFEVQTWTNGMVFSQQLPDDYLKNSIPIKTKLKKTDLRALHPVDIVATKIGRLNERDIQDIESCIKKFKLKKSQISKRAKMVQYAGNEMVYENNLQYVLKGFFTGKLKKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN1</accession>
    <name>K0IIN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate synthase subunit alpha</fullName>
            <ecNumber evidence="6">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">korA</name>
        <name evidence="6" type="ordered locus">Ngar_c28550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28550"/>
    <dbReference type="EnsemblBacteria" id="AFU59775">
        <property type="protein sequence ID" value="AFU59775"/>
        <property type="gene ID" value="Ngar_c28550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2827"/>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OMA" id="AGYYIYG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="259"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="537"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="655" mass="71525" checksum="84B01694F35FBD7D" modified="2012-11-28" version="1">MEKTVTNSLSWVIGGAQGSGVDSAANIFSRACAAGGLHVFGKREYYSNIKGEHSYFTVRVSEKPVHSHVNDINVLVSFDAETVFRHFEEVTPGGAIIYDTDVADTLLSEVPTIDDHAMARIKKALEKAGLGLSVKDALEHARKRGVVLFPIPFFQILQEFAQKTNDPALSKLTRMVNVMALSASMAIMDFDSEVLARAIQFIFRAKKKVADLNVSASIHVYNYAKAKFAGSNNFAYRLKTRPTAKDLIIVQGNQSSALGKMVAGCRFQTYYPITPASDDSEFLEANEILDLNDSGKKGSTVVVQTEDEIAAIAMAIGSALTGARSATATSGPGFSLMAEALGWAGINEVPVVISLYQRAGPSTGLPTRHEQGDLNFAINAGHGEFPRIVLASGDIEESFYDTIKAFNLADRYQMPVIHMLDKAIANSVTTCRNFDPGKVKIDRGAIVRQVITEKDKGLAGNYLRFKLSSDGPISPRVVLGTKDAIFWNTGDEHTEEGHITEDPELRVQMMDKRMDKLQVALKEIPDEDKAVAYGDGDIAIVSWGSTKGAILDMKEKLAGEGIRIKFVQVRLMNPFPSELVKSMLKGAKTVIDIEMNYSGQLGSLVRQHTGIEADYQIVKYNGRPMSLDEIYNAVKRIMNDGGRNAPRRQVLKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ6</accession>
    <name>K0IIQ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c29010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59820">
        <property type="protein sequence ID" value="AFU59820"/>
        <property type="gene ID" value="Ngar_c29010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29010"/>
    <dbReference type="HOGENOM" id="CLU_1163829_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2901-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="238" mass="24985" checksum="12AA144A90385F05" modified="2012-11-28" version="1">MTKFPTYGMAGIGIAAAIGFVFALSFVSNNNAAVETGGREEDAGLLSSEPSSLLVQHKSGGDQGMAAERTQAEDDGMPPSAEGDNASMMMQQQKATTSPALLTLASITASDGITGEAIGDVVPEMQFEMHRPVFIKSSFVNANDAPLPSHLITMGIGSKNDSSATFEEQDQLLYQQAATFHGDIGANGSVELELYWNPASPGEYALLLFSVAPEDLASSGEPIRPVESIPIRVVQNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ7</accession>
    <name>K0IIZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59970">
        <property type="protein sequence ID" value="AFU59970"/>
        <property type="gene ID" value="Ngar_c30540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30540"/>
    <dbReference type="HOGENOM" id="CLU_1340767_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3054-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="205" mass="23635" checksum="C0A5A311DA2DB209" modified="2012-11-28" version="1">MFYISRICYYWIAELPVVSDSYMGIFMPPDISFRIKQFMAAKVDFPFIRKDELMAAFYLFGKDYGVPESEVKAATDIAKTTVEQVARDIRLYAATPQKMDARFTRENYTKRSLQIVVDSGAQADLDSRVAGDPAILSDCFAQHVAYHKQGFFFELFHPFKGEQLSASLKNRLEGRMLLLGFNVKDRQSLPFKSSLEPFFKWMLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ19</accession>
    <name>K0IJ19_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="6">IMP dehydrogenase</shortName>
            <shortName evidence="6">IMPD</shortName>
            <shortName evidence="6">IMPDH</shortName>
            <ecNumber evidence="6 12">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 14" type="primary">guaB</name>
        <name evidence="14" type="ordered locus">Ngar_c30890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 12">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 11">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="6 12"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30890"/>
    <dbReference type="EnsemblBacteria" id="AFU60005">
        <property type="protein sequence ID" value="AFU60005"/>
        <property type="gene ID" value="Ngar_c30890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30890"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3061"/>
    <dbReference type="HOGENOM" id="CLU_022552_1_0_2"/>
    <dbReference type="OMA" id="GSHCTTR"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 12" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6">
        <location>
            <begin position="381"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="6 7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU60005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="477" mass="51334" checksum="90E6436186021A0C" modified="2012-11-28" version="1">MDIREGLTFDDVLLVPKRSPIVSRSQTDLRTKLSRNITLNIPIISANMDTVTESGMAIALAREGGIGIIHRFMTIEDQVDEILKVKRSESVMIEQPYTIKPDVTVAEAKKAMAEYGVSGLLVEEGGKLAGIITRRDITFENNNRRKVSELMTKEVITAKAGLTIDQAKEILHKQRIEKLPVIDDKRRIVGLITSKDILKMEQYPHASKDKKGRLLVGAAVGVKGDYLERAEALLEAGADVLVVDIAHGHSDNAINTVHMIKKAFPSCELIAGNVATGEGARDLIKAGVDAVKVGVGSGSICITRVVTGSGVPQLTAVIDSVSVARDYDIPVISDGGIRNSGDITKALAAGASSVMVGSLFGGTDESPGKTLVKNGKKFKMYRGMASFYASLGRKYREEGPQVVDSDDLNDYVPEGVEAMVPYKGSVVEIVRQLAGGLRSGLSYCGAKTIAEMQKNAEFIRMTSAGYTESQPHDVDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ72</accession>
    <name>K0IJ72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c13290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13290"/>
    <dbReference type="EnsemblBacteria" id="AFU58267">
        <property type="protein sequence ID" value="AFU58267"/>
        <property type="gene ID" value="Ngar_c13290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1284"/>
    <dbReference type="HOGENOM" id="CLU_065506_1_0_2"/>
    <dbReference type="OMA" id="YQWTPLK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1327-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018688">
        <property type="entry name" value="DUF2182_TM_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09948">
        <property type="entry name" value="DUF2182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="27243" checksum="B3B7665F28774ACC" modified="2012-11-28" version="1">MAAPQSALSVSLFVAVWTAGMAAMMFPAISPVVLLYNRLAKNSDSNATLLVEGGKGPYSVKMVLFIGCYLAVWALTGLVLLLGWSLLLNSAIAATGLSSIIYGSILVAAGAYQFSPLKAKCLGYCESPMSFFMRRWRNGTLGAVTMGTYHGLYCLGCCWSYFLLMVALGWMDILWMALFAGIIFGEKMWSRGIWIARAAGIGLAIAGGIAALGMIDISGYGAMTSDQGMQEPSSMQDRMEDSGMQDQMSDGGMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA5</accession>
    <name>K0IJA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58332">
        <property type="protein sequence ID" value="AFU58332"/>
        <property type="gene ID" value="Ngar_c13950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13950"/>
    <dbReference type="HOGENOM" id="CLU_3130972_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1393-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5753" checksum="7565099B9B08CFB4" modified="2012-11-28" version="1">MSGDPERLKWYICRICGAKFAFVYDKEQHAVQTGHEEFSEKEMNNSDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB9</accession>
    <name>K0IJB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59203">
        <property type="protein sequence ID" value="AFU59203"/>
        <property type="gene ID" value="Ngar_c22730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22730"/>
    <dbReference type="HOGENOM" id="CLU_1976605_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2271-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="13981" checksum="AE200AFE7AD02855" modified="2012-11-28" version="1">MTTTLYKNLYFYSLLHGKFKIIADEADEGGEMRYGGWTALKRPADGVWVKDYCFYTYKSKDCGSSCGSTVYTIPSTNVIFVKGYNAGSYSIVVKGYNAGSYSIGSLFDAYAWVISHSALKALLMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF7</accession>
    <name>K0IJF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14610"/>
    <dbReference type="EnsemblBacteria" id="AFU58397">
        <property type="protein sequence ID" value="AFU58397"/>
        <property type="gene ID" value="Ngar_c14610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14610"/>
    <dbReference type="HOGENOM" id="CLU_067068_0_0_2"/>
    <dbReference type="OMA" id="NSSYCNG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1459-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005357">
        <property type="entry name" value="UCP005357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="375" mass="42084" checksum="1499B99005F19A4F" modified="2012-11-28" version="1">MSTELPRSSLRYTSSGLQKVFPLASGYKSCLKKKIWFDILTPKQVMFFRRAVTLLRDSGHDVLCTSRQYREAIELARIKKLDLIVVGSHGGADRYGKLRQSANRTFELAEVVERFRPDAAVTFASPEGARVAFGLGIKHISFNDSPHAEAVARLTVPLTSNLLCPWVIPYSAWTGYGIAKKDITRYHALDPVAWLKHDETSEIEQDKKNTILLRLEESKASYIADRKLGTAKTIDDFVNDLWQSANIVMLCRYQDQIAEIEARYGSKVQVLKDVVDGTALIKSIHLFVGAGGTMTAEAALLGKPTISIAPLRFHIEKYLVRSGLVKRASNSKSLVKMGRKMISDEHYMKAQKKKAARILARMEDPTDRMINALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL2</accession>
    <name>K0IJL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58467">
        <property type="protein sequence ID" value="AFU58467"/>
        <property type="gene ID" value="Ngar_c15330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15330"/>
    <dbReference type="HOGENOM" id="CLU_2930311_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1531-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="7097" checksum="73B1A7B1A1D2EFF1" modified="2012-11-28" version="1">MSLDKDIRNIIETPIENDLAAPKVPKKRMPKLKRVWKCEHAYDFTVIEPATTRVWSKVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ3</accession>
    <name>K0IJQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60300">
        <property type="protein sequence ID" value="AFU60300"/>
        <property type="gene ID" value="Ngar_c33850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33850"/>
    <dbReference type="HOGENOM" id="CLU_1582946_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3386-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="19928" checksum="3283092F69520A36" modified="2012-11-28" version="1">MVEEVPLTAIAVIVGTATAVISAFTIYYRKKQYEIMAKQYNLNALLEVFQLLNNETHRKARQAVYRYHRSRLDGKNPDEEEVGQEIAMVRSDFDMIGTFIRNELISKEVFLDAYWDTTLICWDALKDNIAKERELRQNQHYMANFEHLAYEARQYKEKYMPRESVEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ5</accession>
    <name>K0IJQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58512">
        <property type="protein sequence ID" value="AFU58512"/>
        <property type="gene ID" value="Ngar_c15790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15790"/>
    <dbReference type="HOGENOM" id="CLU_2748319_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1577-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8178" checksum="EF27E563808BB4AD" modified="2012-11-28" version="1">MREALIMTAGTELIFTLKCSCGKTPNAYNVEGLCSFRKHLMECKTAEHEPLTYFWLYTIGEIIREWRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJU6</accession>
    <name>K0IJU6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58542">
        <property type="protein sequence ID" value="AFU58542"/>
        <property type="gene ID" value="Ngar_c16090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16090"/>
    <dbReference type="HOGENOM" id="CLU_1096677_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1607-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="264" mass="29008" checksum="0D6A19B63C66FD66" modified="2012-11-28" version="1">MCGHEIIIAMAVLDPNVLNPFVLVSPAVAPALAVAITAISVSLSLMISRYFFKSYTFSGFGYLLGLPVGFAFLGASFLFELSSLMYRADPLLYPAFFWIQMSLQSEALALIALSYYYKSSDASESGKRVRARDVLVTTLPLVMVAIPFLVPTFSLASQPYFNYAGLADLSFYMRIFNMAVIGYIFKSTIASLVRAANIKLLYVPAAFALLWLEQYSLVLAYFDNSAIAFIGSAAARMAGLALFAYIMHSVTSRRKMEIEARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX4</accession>
    <name>K0IJX4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c16390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16390"/>
    <dbReference type="EnsemblBacteria" id="AFU58572">
        <property type="protein sequence ID" value="AFU58572"/>
        <property type="gene ID" value="Ngar_c16390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16390"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1637-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="9852" checksum="37C485DB9E152E58" modified="2012-11-28" version="1">MPGAYVMVNTLPGMEKPVLDEIAQIPGVVSVEGVYGEFDLIVRIEVPVGNTVDFVINKLRKVSGIKSTRTVSTIDGERKSGTGMDYLGPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX9</accession>
    <name>K0IJX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative membrane alanyl aminopeptidase</fullName>
            <ecNumber evidence="12">3.4.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Ngar_c35070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="12"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35070"/>
    <dbReference type="EnsemblBacteria" id="AFU60420">
        <property type="protein sequence ID" value="AFU60420"/>
        <property type="gene ID" value="Ngar_c35070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35070"/>
    <dbReference type="HOGENOM" id="CLU_014298_0_1_2"/>
    <dbReference type="OMA" id="CFDYPGQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3508-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="11">
        <location>
            <begin position="52"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="10">
        <location>
            <begin position="253"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU60420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="843" mass="96534" checksum="89BBDCA002A5A560" modified="2012-11-28" version="1">MRCRDTFILSSAASSAYPTMHTTHGEDDARKKFELPGSRPHYPPSLLFTITHMRLAIEPDLQERSISCEQKLSITILHDTDTIELDAAELQIKSVSAASKLEFRSLDDKLAVKLGRIIKEGSKIELAIAYSAKPRQGFYFVAPDKHYPDKHLEAWTQGETTQAKHWFPCIDHPQVKFSSEISVTVQSGFTAISNGRLQRVEQRGNKKQVFHWLESNPHPAYLASVVVGKYAEIKDGSLQYYVPPERKADAPRTFDQTPKMIKFFEEYLGTKYPYEKYAQVAVQDFIYGGMENSSCTTLTLDTLHDKKAHVDFTSDYLISHELAHQWFGDLVTCRDWQHIWLNEGFATYCEALYWEASRGNDEFQYYVMQTADDYFEEAGTRYTRPIVTKVYKHPDDLFDRHTYEKGGCVLHMLRHHVGDKYFRRSLKTYLQRFANSTAETDDLRKIFELETGKSLQQFFDQWIFREGHPELKVDFSQDGDIAKIKVEQVQAGDPFEFALDVNLAFARGKKTRYTFKISEKESVFQIPVDSEVEWFSVDPEFKILKTISIRAPKEMLVRQLRDGDTVIERVEAARALKDKSSDAVIDALKDAVLHDKFWGVAAEAAKALGAIRTDYAYEALKGCLLVKHPKARRAVVKAIGEFKKEETLELLKPVLQKDESYFVESEAATAIGKTKSRQAIAILKKAAATETFQNVVAQGAIAGLKEFAGDKDIADFLVEKSKYGNYHRVREAATFALGKFADNHAVFDHLKSLLTDRWFRVRINACRALADAELTKAIPDLTWVAEHDLDHRVRRVADECINIIKEATKKPKEVAQMREELDRVKSKNLELLQKVDRLERELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK13</accession>
    <name>K0IK13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58627">
        <property type="protein sequence ID" value="AFU58627"/>
        <property type="gene ID" value="Ngar_c16940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16940"/>
    <dbReference type="HOGENOM" id="CLU_3094241_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1692-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5879" checksum="C831AB9DE5BB443E" modified="2012-11-28" version="1">MQILTVETEKREGIADGDAFVCNRCKSKPAEIFQVNGEYCLDCWQAITHTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK44</accession>
    <name>K0IK44_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59598">
        <property type="protein sequence ID" value="AFU59598"/>
        <property type="gene ID" value="Ngar_c26770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26770"/>
    <dbReference type="HOGENOM" id="CLU_1830651_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2677-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15928" checksum="51047875E915AE51" modified="2012-11-28" version="1">MPQNKSLVSEEPSSFILKIQNDELERRLFVAHSFYVSIKRDWMRGTHMLFVRKDAFIGSGTIDRIVMLDDLQEEEEKKMCIKNNWYAKIIFSKLARFLPTVPVQDTPAAAQNPLALHGASISGPEALQIEILARAKIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK50</accession>
    <name>K0IK50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58662">
        <property type="protein sequence ID" value="AFU58662"/>
        <property type="gene ID" value="Ngar_c17290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1703"/>
    <dbReference type="HOGENOM" id="CLU_080344_1_0_2"/>
    <dbReference type="OMA" id="DVHDKPA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1727-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="30032" checksum="D07F388AEB707999" modified="2012-11-28" version="1">MSSNQNVNKNTKIALFAGILAVGLLVAVLVGSFPLTSRGAAAQESGLQHPVLHNNTSIVSATGTATTSVKPDKVSIAVGVETNGTSAEEAASKNADLIAQIIAALKELGITEDQIGTSNYNVFPVYQHKEPAEVCIMIYPPPPKCQPGQEIVGYRAVNSITVTLDVDGEIDAGEVIDTAIEAGANNVNGIYFFLSDERQEEVRDSLIKEAIDSAKYRAEVAASALGYTISGVQSIHLNDVNFPIFYGRSALSESAVSSTPIMPGEQQVSTSVTVVFYMPDIAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKD3</accession>
    <name>K0IKD3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c27670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27670"/>
    <dbReference type="EnsemblBacteria" id="AFU59688">
        <property type="protein sequence ID" value="AFU59688"/>
        <property type="gene ID" value="Ngar_c27670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27670"/>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2767-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="376"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU59688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="596" mass="65726" checksum="C8138AFAF985BD45" modified="2012-11-28" version="1">MKIRAKLTIVTISLIIASIVIPSIIALESFSQELESQITHNLEQESIRSIDKISRFLFERQGDIKLLTDPSNSIMRGPSISQKLEYLQSVEKTYQVYSAFSIYDKNGIKIADTHDFSIGADSSNEPFFVNAMKGNIHYDSVPTFSNDVGQYVMHFSGPLLNEDGNIDGVLAGIIPISRIYDIVEQASQSRENLQADLVSSGGLVIYSNYDKEAIMQKNLSYLPIFGKIAVSGNPSESYIGSVNDVDEAEFFSNDETIYVAASEQGFLDYKGNQWILIIAVPTEVAFKEVTQLQNNFIIVAIAILSAAIIPVIIFSKAYTQSLIKLKNAAAEIAKGNFDIAVEINSNDEIGELSQQFDKMKNDLKDRERLKDEFINIAAHELRSPLQPIISYNELALKGLMDKDEALRIIDSESQRFIKLANDILDVTRIEGGALSYNMQRIKIIDIISRIVSSTKISDKLGSDVSIDLVKDKISDAVEVYGDENRLSQVFMNIIDNAVKFTRKGRIRIETRVQENKLGIKISDTGGGIPAEIMPKLFGKFVTKSVQGGTEHGTGLGLFISKAIVTAHGGEIYAQNNSEGGATFTILLPIADGGVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG1</accession>
    <name>K0IKG1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59743">
        <property type="protein sequence ID" value="AFU59743"/>
        <property type="gene ID" value="Ngar_c28230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28230"/>
    <dbReference type="HOGENOM" id="CLU_2821042_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2823-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7931" checksum="DC621A7AFB394F56" modified="2012-11-28" version="1">MEQTAEDERMKHTIVNIVPHINMKVEEITGTTRYRISKDKEPQYRHLLKLLGEWKLINFEKLIPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM4</accession>
    <name>K0IKM4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59042">
        <property type="protein sequence ID" value="AFU59042"/>
        <property type="gene ID" value="Ngar_c21110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21110"/>
    <dbReference type="HOGENOM" id="CLU_191934_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2109-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="9362" checksum="A0E1468DB5BF5E5A" modified="2012-11-28" version="1">MRHHYAYLRKVLGEKKETLLQMIRKVGNTEQRKVNDILYTRSAEREREKKKEKKKERKRELVNIAKQNNTCIFCLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKY9</accession>
    <name>K0IKY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60063">
        <property type="protein sequence ID" value="AFU60063"/>
        <property type="gene ID" value="Ngar_c31470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31470"/>
    <dbReference type="HOGENOM" id="CLU_820436_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3147-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="338" mass="36873" checksum="F46F59B4F9479259" modified="2012-11-28" version="1">MKNALWPKRWQLPLLLAVASLSFHLLSFTSVVNANDQANSSPIIINEVEIDAPSNADDPLAWVELLNTGGTPVPLSRLNLTIITGDKEGDNVTHVSLKPDNGDPTMPAHSHHVVPVRTNLDHYLVGLQLFEDGVLLDEVQGLNDALADDRTWQRYPDGEDTGSFEDWVFAESTKGEDNGNLGKAIAECYLNPLCMSLDTPAHKSHVLNVDETAFTVDTFSTSSVTGMDLDQEEKKLVVRLSKSSEESDLSFIHISFPKTLLSGDFIVNIDQGESQQPFFAVENNTHSRLIIEFGPGDRTVEIVGTNVAPEFGGASILLAIASTTLALIIVARRYLAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL68</accession>
    <name>K0IL68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase alpha chain</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ordered locus">Ngar_c32680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32680"/>
    <dbReference type="EnsemblBacteria" id="AFU60183">
        <property type="protein sequence ID" value="AFU60183"/>
        <property type="gene ID" value="Ngar_c32680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3264"/>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_2"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="21157" checksum="7176FAE645C882D7" modified="2012-11-28" version="1">MFTGIVEGMGRVRSVSKSKRGADTIMRVSLGRLGRSLKRGDSVCINGACLTVTKLSKGEAEFEMVAETIRRTNLGKVKAGDKVNIERSMKVGDRLEGHFVLGHVDGTGIIEDIQKLPSETKLWIKLDKGLAGSLVSKGSIAVDGVSLTLVDIDGDRVSVSLIPHTLSVTTLGLRRKGDRVNIETDILGKYVASNLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL69</accession>
    <name>K0IL69_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c24280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24280"/>
    <dbReference type="EnsemblBacteria" id="AFU59352">
        <property type="protein sequence ID" value="AFU59352"/>
        <property type="gene ID" value="Ngar_c24280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24280"/>
    <dbReference type="HOGENOM" id="CLU_1136086_0_0_2"/>
    <dbReference type="OMA" id="VTWINAS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2426-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018024">
        <property type="term" value="F:histone-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="PTHR13610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="4">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="29136" checksum="21DB5BDBE7F07D5A" modified="2012-11-28" version="1">MELEEFLSSLPQAIISGEAVSLPDNVIRRIFKFAKLKKSDVFYHLGCGEGNAIKIAAEEFGVKRSVGIELNEATAAKARERVAGIKNAEIVNADIRKADISDATVLFFWFNDPEMVDAMTRRFKKLRDDTRVITIWAPLGMTLPDRVDFPFFVSKKPFKRAKSIRQQIKAIYRTDCIDFTAAWLLAERYIDALEVVPSDYRRFVNMLQGMVIWINAWNMGVACEDKIPPPVQTYVGILRTFFNIDLTSMIKKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE1</accession>
    <name>K0ILE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59452">
        <property type="protein sequence ID" value="AFU59452"/>
        <property type="gene ID" value="Ngar_c25290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25290"/>
    <dbReference type="HOGENOM" id="CLU_1551873_0_0_2"/>
    <dbReference type="OMA" id="FWTRNPK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2528-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="19662" checksum="D86A55FB51D92B03" modified="2012-11-28" version="1">MADNSFIASASLTKSQDSVKSGQPLTLSLSFKIEGAIREVFSQKNWERAYNKHDNGFRMTIEVDLKSGRRTVMPIKFVRKAALFWTRNPKIPYRIWVSIVKDDAPFYPLTEEEARSLLFDVNKVIELSGNDLDSGTQKLYADIRVSWGKHDYTEPTEIKGRSNEVELMRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG1</accession>
    <name>K0ILG1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfoX_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25500"/>
    <dbReference type="EnsemblBacteria" id="AFU59472">
        <property type="protein sequence ID" value="AFU59472"/>
        <property type="gene ID" value="Ngar_c25500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25500"/>
    <dbReference type="HOGENOM" id="CLU_2152690_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2549-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12482" checksum="3D49F13A30917C30" modified="2012-11-28" version="1">MMVSNEQLASKIRALTKYKGLSEKKMFGGIAFMLNGNMCFGTIKNDLVVRVGPERYEDALTTKANGLHGPVDQGIRVRRSERMVKRRNSQKMAGHGHRLCLFASKKAIAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK4</accession>
    <name>K0ILK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60478">
        <property type="protein sequence ID" value="AFU60478"/>
        <property type="gene ID" value="Ngar_c35650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35650"/>
    <dbReference type="HOGENOM" id="CLU_204970_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3566-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6206" checksum="DC28B30457746BC5" modified="2012-11-28" version="1">MAGRDTCILCGKPIVARPIVEKINGREYSFDKQECALTLKKLKSVYGSDFCFNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK6</accession>
    <name>K0ILK6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57134">
        <property type="protein sequence ID" value="AFU57134"/>
        <property type="gene ID" value="Ngar_c01850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01850"/>
    <dbReference type="HOGENOM" id="CLU_1987688_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-185-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="13777" checksum="78CB9F5FF03263D9" modified="2012-11-28" version="1">MSTNGDGSTKRRDLPLPPVSGYPDEAEALRRNQGLGMARPAQKVAAETGAANELSDILSGIDYPADRDSILDFLDRSKPDMRDFDIVVNAVRLLLKGKQYRSPSEIAADLGNINEEYNRTRGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM5</accession>
    <name>K0ILM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c26450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26450"/>
    <dbReference type="EnsemblBacteria" id="AFU59567">
        <property type="protein sequence ID" value="AFU59567"/>
        <property type="gene ID" value="Ngar_c26450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2620"/>
    <dbReference type="HOGENOM" id="CLU_062658_5_1_2"/>
    <dbReference type="OMA" id="IFVRQYR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2645-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19307" checksum="C3FCC4304E2C9B0B" modified="2012-11-28" version="1">MGRGSVRAIRSSTIYSGGINLRRDRFMLGGKVIDKEIVEHKDSVGIVAISGSDDVILVTQYRRAADRVLLEIPAGKMEKGETPRQAAIREMAEEIGYSGKLEPLTRWYLAPGYSTELMHVFVATNLRKIVRGPLDDDENIKIKKVKLSAAVKKCLSGEIQDSKTVAALLVYSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ7</accession>
    <name>K0ILQ7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps10p</name>
        <name evidence="4" type="synonym">rps10</name>
        <name evidence="6" type="ordered locus">Ngar_c02910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02910"/>
    <dbReference type="EnsemblBacteria" id="AFU57239">
        <property type="protein sequence ID" value="AFU57239"/>
        <property type="gene ID" value="Ngar_c02910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.284"/>
    <dbReference type="HOGENOM" id="CLU_122625_0_1_2"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11564" checksum="491043F7A77EE3AB" modified="2012-11-28" version="1">MPQAARIKLTSTNLATLEGVCTEIKGMTEKSGIKLKGPHPLPTKKLKVVTRKSPCGQGTNTYDKYEMRIHRRVIDVGADDRAIRQLMRLKIPDDVYIEVSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU2</accession>
    <name>K0ILU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57354">
        <property type="protein sequence ID" value="AFU57354"/>
        <property type="gene ID" value="Ngar_c04070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04070"/>
    <dbReference type="HOGENOM" id="CLU_2985796_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-406-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6739" checksum="527DE3FD92B53D56" modified="2012-11-28" version="1">MFVGAEYIKVDEKEKRVNNSAKYYRAKIEKVDHNPFFRLYCFGFLCNDCGTLPKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU9</accession>
    <name>K0ILU9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59687">
        <property type="protein sequence ID" value="AFU59687"/>
        <property type="gene ID" value="Ngar_c27660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27660"/>
    <dbReference type="HOGENOM" id="CLU_3075476_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2766-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6326" checksum="8CC9CD58CEE8F337" modified="2012-11-28" version="1">MGVSVNGHQGMLDRIYFCNNCKAVFLFQADVEYHNMTSGHSSIKTLSFDEYYNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV5</accession>
    <name>K0ILV5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57384">
        <property type="protein sequence ID" value="AFU57384"/>
        <property type="gene ID" value="Ngar_c04370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04370"/>
    <dbReference type="HOGENOM" id="CLU_142654_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-436-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="16885" checksum="80602FF6C846B3CD" modified="2012-11-28" version="1">MKFSRQVVVWSVVLYFALGIPISLLHEAGHAYVCSASGFDYQIWVDATGGHMICFGRVQDSFVYNAMGGVFGLAGSVAIITAWLLLAKRHYAILAVGLAYSADQAAKIILEGLYASVYESGAIDGYITAMQVVSWIGFMLYFARVKEPAKIAASDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM05</accession>
    <name>K0IM05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57484">
        <property type="protein sequence ID" value="AFU57484"/>
        <property type="gene ID" value="Ngar_c05410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05410"/>
    <dbReference type="HOGENOM" id="CLU_856899_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-539-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="324" mass="35792" checksum="CD1CE9442A6255CD" modified="2012-11-28" version="1">MQRPRYELPLPQPQKICRHAAIVKNLAEKLAEFQASEIIDADMILGRIGRIDTAKLIWENHEEHFLNNSGQFQVTEPDGTNLYLWYTMDEASDTPNVMTDHSGGGRHGTVQLGSGVKLENKIVANYTAGKRLSKSFYCTGNGTEVIRRAHDSDLVVNQNQSFSLWLYPTDLSLDGGTSRRCVHKFEDANNGFQVTYDDMARIQYVVEKAGVGYSARCATGALLLNAWNLIVCLWQNSTNTPTIVVNNVAYSNVGGVPGFNSGTTDLVIGRQGNNTTSGRTKGYIDDFRYWQSKVLSTTEYGNLWANKLSIVALPGRVGLCDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM19</accession>
    <name>K0IM19_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA-type ATPase domain-containing putative archaeal cell division protein Vps4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c05660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05660"/>
    <dbReference type="EnsemblBacteria" id="AFU57509">
        <property type="protein sequence ID" value="AFU57509"/>
        <property type="gene ID" value="Ngar_c05660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.542"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_2"/>
    <dbReference type="OMA" id="ATIMSKW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-564-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="SSF116846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="3">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="169"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="413" mass="45886" checksum="96B85CE8B4622438" modified="2012-11-28" version="1">MSLAPQELENSASKYAAEAIRLDSQGSRGMAIQSYQRAIEALVKLVQIYPDYKLNKVYMERANAYQNRIKALQMSHGLEEEERPPTHIDNSSGKQEPSNGHGTKPAASSSGSSKSANVETLKADFDDLVMKEKPKVSWNEVIGLEDAKRAIRESIVYPMKRADLFPLGWPRGILLYGPPGCGKTLLAAAAAAEIDGYFINVDAASMMSKWLGEAEKNISKLFKMARNLNESEGVPVLLFIDEIDSLLGTRNSEVGGEVRVKNQFLTEMDGINGKSKESQLYVIGATNKPWSLEAGFLRRFQKRIYVTLPDTASRTNLFAQYTGPLNVEGTLRVEELAKVSEGYSASDIKDICQSVQLRVVNELFESGKAMEAGANPRPINMLDFKEILKIRKPSVSIDMIRAYMRWSDQFKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM20</accession>
    <name>K0IM20_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59902">
        <property type="protein sequence ID" value="AFU59902"/>
        <property type="gene ID" value="Ngar_c29840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29840"/>
    <dbReference type="HOGENOM" id="CLU_036012_2_0_2"/>
    <dbReference type="OMA" id="GHYDHTD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2984-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="339" mass="37304" checksum="516C8416BFE860C4" modified="2012-11-28" version="1">MQQPSKLLFAQLALSHSMRLLPVSKMSITLLMDNVTDRLLASSPHAHRPPLGRDGKFLPAPLAEHGFSALIEIQYGGEDGGSVQQQKTYLFDTGTSENGVIFNSDLFGIDLLKIDAIVLSHGHFDHFTGLQSVLKRISRPVRLYAHPDAFLRRWDIFPDGTRLINPVLDEAALKEYGSIIHKNEGPTGLPDEKDPRLIISGQIPRETSYEKGFPPQYAEVEGKGLVHDPLVKDDQALIAKVKGKGLVVVSGCGHAGIINTINYARRLGGTEKIHAVLGGFHLSGRLQEEAIEPTLKDLQSADPDYIVPCHCTGWKAVNTIIQRMPEKFIPPSVGTRFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM21</accession>
    <name>K0IM21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59907">
        <property type="protein sequence ID" value="AFU59907"/>
        <property type="gene ID" value="Ngar_c29890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29890"/>
    <dbReference type="HOGENOM" id="CLU_128582_0_1_2"/>
    <dbReference type="OMA" id="TYYISIN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2989-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14958" checksum="558741259F3B57D6" modified="2012-11-28" version="1">MSRPQADPETRKYKEKCNSILAISPRIRYAGIMNRFGRTLAGGLRKGVVPLLKQDEARNEYFIEATRNQLRKNFERSIGKTEYTFTENEKVKILTIASEEHFYYITMEKDTPANEVARIIEEARKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM3</accession>
    <name>K0IMM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10770"/>
    <dbReference type="EnsemblBacteria" id="AFU58019">
        <property type="protein sequence ID" value="AFU58019"/>
        <property type="gene ID" value="Ngar_c10770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10770"/>
    <dbReference type="HOGENOM" id="CLU_075000_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1075-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="240" mass="26222" checksum="CBE35E7368ADE1C0" modified="2012-11-28" version="1">MKLDKLKDIKADEFMVFASLPDMGRVGGLVSSFLSQHLKAEQVAEITSSDKPWVSYTDGVVKSASDAYKIFYDKRHKLLIFTGESQPQDPAELHRLCNMLLDYVQSIGGKVTRLYGAGGYLREQVTGAPRVCGVVNRPELKRVLAKAGIDFVGNEITSITWFNGLILGLAAERGIDAIGLFGEIAETTVPQPLAAKTIISAFSKLEDIPIDTKPLDRQYESILEEIQKTKGSSKFGPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ1</accession>
    <name>K0IMQ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35640"/>
    <dbReference type="EnsemblBacteria" id="AFU60477">
        <property type="protein sequence ID" value="AFU60477"/>
        <property type="gene ID" value="Ngar_c35640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35640"/>
    <dbReference type="HOGENOM" id="CLU_766412_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3565-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="361" mass="41362" checksum="0FF8C57772E0F9A4" modified="2012-11-28" version="1">MGKIADNNNNQDAFGTVTDDDQDSYNSIFWRLLSGASKRIDCYFDHVSKLDPSFAKELMDLLAGPKKRKELQIHIVTNITKDSLPIIKQLMKSSEVYHMEGFSGSFYIVDSSAYLYDVQESDGVDDHQKQRPHRLLYSTHPQFVKMQQQLFENLLSRVVPAKEKLKQIERGTEREFIETIQDPSSALQLAKELVRSASFEILVLFSTINSFYRAEKDGLLDLLGEASSHGVAVKVLIKIDDEAVKDASKQKIKQKHERINVNFIERSVRSKITTIIIDQTFSLAIEVGDDSKNDFSAATGLSTYSNSESTVFTYYSMFENLWIQAELERQGKVRQAYFQMFKGQKLKDEVYRRKWSLADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY0</accession>
    <name>K0IMY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58409">
        <property type="protein sequence ID" value="AFU58409"/>
        <property type="gene ID" value="Ngar_c14730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14730"/>
    <dbReference type="HOGENOM" id="CLU_2748318_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1471-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7943" checksum="1D30906077117159" modified="2012-11-28" version="1">MTGILHYSYGLGTVEPDENGIYRLTFVTPCEAQVELSDELDMLSYERSNCVADDGNLTIPHFDIIFRISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN33</accession>
    <name>K0IN33_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rps4e</name>
        <name evidence="9" type="ordered locus">Ngar_c17410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17410"/>
    <dbReference type="EnsemblBacteria" id="AFU58674">
        <property type="protein sequence ID" value="AFU58674"/>
        <property type="gene ID" value="Ngar_c17410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17410"/>
    <dbReference type="HOGENOM" id="CLU_060400_0_0_2"/>
    <dbReference type="OMA" id="FPVGLMD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="237" mass="25905" checksum="6A44354C65A01DEE" modified="2012-11-28" version="1">MGKKGGDTRVKRQMAPTFWAIKRKQSQFVLRVKPGPHPKHRAYPLGMVLRDVLKVASTMHEAQRILNAGKVKVDGTVRRDSNLAVGLMDVVELATGQAYRMVPKNSALLDSIAIEQSEKGVKLVKVTSKATIKGKKIQYGFHDGKTLISDQKLKVGDTCVIDLPKVQVKDHIVFEKGATALIITGENAGTVGKIEDIQDGIFSLPKRALVSFDGKSVELPVEMVMVVGKDKPVIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN45</accession>
    <name>K0IN45_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58734">
        <property type="protein sequence ID" value="AFU58734"/>
        <property type="gene ID" value="Ngar_c18010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18010"/>
    <dbReference type="HOGENOM" id="CLU_1821075_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1799-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15657" checksum="4DE167E70F955B7A" modified="2012-11-28" version="1">MLPVQNGKITKISNGTTFLRDWSSDGRFIIGDNLVMISPNGIILQVPEGLEEISIPSISPSNDQLLFIAKHEIEMDTNYDVFKYKLSDGSIQQLTNNPKLTAQGLVERIVGAEWLSNGRILYVQSETDTKDTSHQTSSLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE6</accession>
    <name>K0INE6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpl19e</name>
        <name evidence="7" type="ordered locus">Ngar_c23130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23130"/>
    <dbReference type="EnsemblBacteria" id="AFU59239">
        <property type="protein sequence ID" value="AFU59239"/>
        <property type="gene ID" value="Ngar_c23130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2288"/>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_2"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="6">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16930" checksum="7B9B78E98B7A9568" modified="2012-11-28" version="1">MVVNIAKKRELVARILGVGANRVRFEPDRLEDVADSITRENIRSLVKSGAIWTVQPAGTSRGRAMEKRSVWKVHGKGPGSKKGKKTARVGKKEVYVIKVRSMRYHLKVLKERKDITNEIYWQLYKKVNGGQVRSLAHLRELVKEAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING1</accession>
    <name>K0ING1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl18e1</name>
        <name evidence="2" type="ordered locus">Ngar_c23890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59314">
        <property type="protein sequence ID" value="AFU59314"/>
        <property type="gene ID" value="Ngar_c23890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23890"/>
    <dbReference type="HOGENOM" id="CLU_2565859_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="8632" checksum="19C4D5292E87687B" modified="2012-11-28" version="1">MRRGMSPSLWATASSCITDEFSSITTSSIASVGTSLIASLRSEFTYCLGILLNLTTILSSDFSTTSTDGEANTCESRPKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI1</accession>
    <name>K0INI1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59414">
        <property type="protein sequence ID" value="AFU59414"/>
        <property type="gene ID" value="Ngar_c24920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24920"/>
    <dbReference type="HOGENOM" id="CLU_117489_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2490-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="17721" checksum="FD7C44D5EAB8DB9C" modified="2012-11-28" version="1">MSTKNLLSKKVVIVAIIAAGAVAAILAASSVVQATAQQEQQKMIWAGEGVPEINGSVSVANETMDFIRENVGVSFVAAAETAQGHVTDGAVLGGHLGVVQGYLVYKFLVANTANQTGYLVIVDAGNGDVLYTSEGQQLGSFGPMSGHWGGHGYGEWGGPWKGHGLGWGIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK3</accession>
    <name>K0INK3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59524">
        <property type="protein sequence ID" value="AFU59524"/>
        <property type="gene ID" value="Ngar_c26020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26020"/>
    <dbReference type="HOGENOM" id="CLU_2748325_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2602-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8159" checksum="85CDF43D798C7C9E" modified="2012-11-28" version="1">MAKKQEKDEGEQKVKVDGTVVKVKTLPPSKVRPAYYSETCDICLLLPSQLDIWKSIERLTMPRRYLQLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM6</accession>
    <name>K0INM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59639">
        <property type="protein sequence ID" value="AFU59639"/>
        <property type="gene ID" value="Ngar_c27180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27180"/>
    <dbReference type="HOGENOM" id="CLU_2021580_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2718-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13311" checksum="7CA7A2167E3B696B" modified="2012-11-28" version="1">MPRLAVHTIVSVLAAAIILFPAFAANATAVMNKVAETTIIVNERCDGPVIAPDLFVKDRAGNVIISQATAGTQLLIEGSVFMDCFQYPENLQTAIFEVKDEQGHTTHLGSRLFLQRTWAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN5</accession>
    <name>K0INN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59684">
        <property type="protein sequence ID" value="AFU59684"/>
        <property type="gene ID" value="Ngar_c27630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27630"/>
    <dbReference type="HOGENOM" id="CLU_094456_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2763-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="20870" checksum="37B5E695387DDEA1" modified="2012-11-28" version="1">MIERQTGSPHLLSSGWLQFFRHVKSLYAAALGIEILCIAAAEIGENLGLHLFGFNLVGIPIAYAMGYALAGFTTFATILGRCDHGRIDSCCSVLEQGTGITSNLKMTFRNFAVGTTRITRLHKQRNLKHILKTSGYILVTAESACILTAEAVDLIFYQYSILLAVPLALLAGAFTVVVPEAYRKMNAAKSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP6</accession>
    <name>K0INP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative major facilitator superfamily MFS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c28190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28190"/>
    <dbReference type="EnsemblBacteria" id="AFU59739">
        <property type="protein sequence ID" value="AFU59739"/>
        <property type="gene ID" value="Ngar_c28190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2784"/>
    <dbReference type="HOGENOM" id="CLU_656603_0_0_2"/>
    <dbReference type="OMA" id="FNEISGW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2819-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="406" mass="43292" checksum="9F5537CC2DF342C6" modified="2012-11-28" version="1">MNASSSGLSTIIPIYMLGLGGQVRDVAIALFLSNLAVTLGAVFWGRLIDAMQWRKTIIAACSAAIAITCGAMYFVSSIPVLMVLSALVGFFSVGPAPVTNLLVMEKSRKEDWLKTFSWTSFISAAGLVVAMVAGYLWLMKYDAQSYAVICSAIAISSLALTIVFVRDPPATLKRRAIAMSPAALVDRLRQVPVMFLKPVADLSLSKLQASVSRKEFLFFAGTGLYFLSGNLLFTPYTPFLKDSGVTDSQVFLAYTILHMSRVFFLPFNHRLVARGGEETMGRLAYLPRMFGIVLAVVAAFLFANNPASILAMTVVAFVAVEVGFSIWSTTTTSSLFKMIPDGRAGSVLGVNSAIIGSGLLIGSIAAGEVAATFGYGATFTLAIAFLGASFALVSKHFKRIVVKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ3</accession>
    <name>K0INQ3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS2</name>
        <name evidence="8" type="ordered locus">Ngar_c28540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28540"/>
    <dbReference type="EnsemblBacteria" id="AFU59774">
        <property type="protein sequence ID" value="AFU59774"/>
        <property type="gene ID" value="Ngar_c28540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28540"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2825"/>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="OMA" id="TSYYSGC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="438"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="591" mass="64087" checksum="98BBCB8CF650FA13" modified="2012-11-28" version="1">MCCSIIGIISSKNVVAPALVDSLKRMEYRGYDSVGVATLATTNRISVRKGIGKVNQVNSSLNLTEMEGFVGIGHSRWATHGGVTDYNAHPHPCCTEDIAVVHNGIIENYLPLKEELVKKGHRFRSETDTEVIAHLLEDHYNASRDIKAAMLETVSQLEGSYAFVAMFANGSLACARLDEPLVIGVSDNAYYASSDVLGFLQYTDQAMFLDNRDIAIIDRDGAHIFTFAGEPVTRGVTKVAWELADVNKGEFAHYTIKEIFEQRTSVKAATYQEEHKIKVFCDTIAAAGNIIVTGSGTSYHTSLITSMAGCRALKKRFEPVMASEFKYNMDSIDKDTVVLAISQSGETADVLSATKLARAAGAKILSIVNVSTSSLARAADVSLAINSGPEIGVAATKSFTGQVSLAYSVLDRISGGRIGFDRDAVSDKITKMLAGSAAIERLVNVTMPKVNDIYLLGRSIHFPIALEGALKMKELAYVHAEGIAAGELKHGPLALMDKNAVVFVLNPDDKTYGDTLSSAHEVKTRGAKIIGISNVSNDIYDAMIEIPKMENELLYPLVEVIPLQLFSYYLALRNNVDPDFPRNLAKSVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP50</accession>
    <name>K0IP50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative molybdopterin biosynthesis protein MoeB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35960"/>
    <dbReference type="EnsemblBacteria" id="AFU60509">
        <property type="protein sequence ID" value="AFU60509"/>
        <property type="gene ID" value="Ngar_c35960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3604"/>
    <dbReference type="HOGENOM" id="CLU_013325_5_1_2"/>
    <dbReference type="OMA" id="VIDGMDH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3597-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="103"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="441" mass="48215" checksum="D4109008334D670D" modified="2012-11-28" version="1">MAKVEFVVPSVLNKGQGEKKIPLEASDLQDAFTKISEQMGDDFKRRVFDHNGKPRSLINIYINGKNMRFGGGLATQLKDGDSVYILPAVAGGAELTSEELQRYSRQVMLEEIGFEGMEKIRSAKVCVVGAGGIGNPVITQLTAMGVGKLRIVDRDVIEVTNLHRQHLYTDDDIGRVKVEAAAERLRKLNPTVEIEPVPTSVTKYTAEGIVKGFEVVIDALDSVDARYALNDACIKYNIPLIYAGAIGVTGSVCTILPNKSACLRCMFPELNEEEMPACSTEGVHPSILYLVAGIQVSEAVKIIIGKEPTLVNRLLYMDLNELSFDRVQMFRQEECPSCGRARKESEVVTRELIIEELCGRDRGKRTWTVTPAEPAPINLVSISKNAESLGYQVKTRGNLGITAINSGKMSVSFLSSGAATIVGAKDEEDAIKIYKTFVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0I710</accession>
    <name>K0I710_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01010"/>
    <dbReference type="EnsemblBacteria" id="AFU57051">
        <property type="protein sequence ID" value="AFU57051"/>
        <property type="gene ID" value="Ngar_c01010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01010"/>
    <dbReference type="HOGENOM" id="CLU_098907_0_0_2"/>
    <dbReference type="OMA" id="GMGEKPC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-101-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="21916" checksum="3A5A05120979BABF" modified="2012-11-28" version="1">MCGGKATRMQQQTDRGGSEKPLLNVGGVPMVECVISALAGSNRFGRIIAAVSPNTPETKEFLKSKGIEIIETSGVGYPQDLSWLLSKLKPERVMVVPADIPLLDAQAVGDIVDSASNKQEPAVSIVLEKEFVENIGAKPSVVFGRYCHSGITIFDTSKVVGETVQERYLVMNRKEIALNVNTKQELELAEKLYSSRAPKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7H7</accession>
    <name>K0I7H7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57186">
        <property type="protein sequence ID" value="AFU57186"/>
        <property type="gene ID" value="Ngar_c02380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02380"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-238-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14462" checksum="4BF648EE2A3A9CA4" modified="2012-11-28" version="1">MYDIAKRFKISREEPLPTGKATKDPWTKVENIDLASYEREYPKSLFNKGVRTNNEDHVGHVVKETDDKIVVFGHYDYRFDIPKSEIVAAGRNVIVGIDFPELLKYGVDRNAPLPTGEPIDKLAEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7W6</accession>
    <name>K0I7W6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57356">
        <property type="protein sequence ID" value="AFU57356"/>
        <property type="gene ID" value="Ngar_c04090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04090"/>
    <dbReference type="HOGENOM" id="CLU_142273_1_0_2"/>
    <dbReference type="OMA" id="CIALDMD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-408-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005560">
        <property type="entry name" value="DUF326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03860">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12848" checksum="8A9A63F62E98BEC1" modified="2012-11-28" version="1">MSTATLQNTKWQSCIDACMRCAEACEFCATSDLREQDVKMMATCAQINRECAVVCWTSASLMSMDSQFAKQFCRLCADICDACAQECDRHNVDHCKRCAQACRSCAEECRRMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8N7</accession>
    <name>K0I8N7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose 1-dehydrogenase 2</fullName>
            <ecNumber evidence="1">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gdh</name>
        <name evidence="1" type="ordered locus">Ngar_c06980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57641">
        <property type="protein sequence ID" value="AFU57641"/>
        <property type="gene ID" value="Ngar_c06980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.673"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_2"/>
    <dbReference type="OMA" id="VWDTTMA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="265" mass="29031" checksum="8048E3F29C705652" modified="2012-11-28" version="1">MNTGRKIAVVTGSSKGIGKTIALAFAKSGEYRGIVVNSRKQAEAEQTAEEIISLGKSDCIAIEADMSKENDCIKLIEETTTHYGRIDVLVDNAGIQHEVPFEETSKEIWQKIIDVDLTGPFVCSREAVKHMMKNQNPKVGCIINISSVHQEIPKPFYVAYAAAKAGIKMMTKTMALELARYNIRVNAVAPGAIETEMNRELKVDEAELRNVLRRIPLERIGTTQEVANVVEFLASDKGSYVTGSIYFVDGGMTLYPAFGPSLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Z6</accession>
    <name>K0I8Z6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57736">
        <property type="protein sequence ID" value="AFU57736"/>
        <property type="gene ID" value="Ngar_c07940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07940"/>
    <dbReference type="HOGENOM" id="CLU_2679061_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-792-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8549" checksum="988395E8898AFDF4" modified="2012-11-28" version="1">MQLHIRDARGFDPAGEGLMLGKGEIPIKDVLKNVHSLKRTIRGTIELDNRHFDHSRCQLEAVRWLVKNVKDVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I941</accession>
    <name>K0I941_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57831">
        <property type="protein sequence ID" value="AFU57831"/>
        <property type="gene ID" value="Ngar_c08890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08890"/>
    <dbReference type="HOGENOM" id="CLU_209485_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-887-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6108" checksum="810DEF420E1F9C2A" modified="2012-11-28" version="1">MLPQPDQIPKEIDVHLATFRKEPWDVDYNLFGYCPICNSRIDEFGFCACGGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA73</accession>
    <name>K0IA73_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58216">
        <property type="protein sequence ID" value="AFU58216"/>
        <property type="gene ID" value="Ngar_c12760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12760"/>
    <dbReference type="HOGENOM" id="CLU_3338594_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1274-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4547" checksum="176228351938EE7C" modified="2012-11-28" version="1">MEDGKSQQVDAVWVHFPSLTLEWLQQRYTGIDRRHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAB4</accession>
    <name>K0IAB4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c13230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13230"/>
    <dbReference type="EnsemblBacteria" id="AFU58261">
        <property type="protein sequence ID" value="AFU58261"/>
        <property type="gene ID" value="Ngar_c13230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1278"/>
    <dbReference type="HOGENOM" id="CLU_012062_16_0_2"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1321-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="17630" checksum="F665407F51F08C18" modified="2012-11-28" version="1">MTATPTGKIQTKFGDISIEFFPDAAPKTVENFIKLAKSGFYDGLLFHRIVPGFVIQGGDPNTKSAANRSRWGTGGPGWTVKAEFNKNKHSRGALSMARAQDPNSAGSQFFIVLKDANFLDGQYTVFGRVTAGMDVVDKIAALKCDAVDAPVDANQARMIKVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAH6</accession>
    <name>K0IAH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58316">
        <property type="protein sequence ID" value="AFU58316"/>
        <property type="gene ID" value="Ngar_c13790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13790"/>
    <dbReference type="HOGENOM" id="CLU_1801612_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1377-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16417" checksum="AC393253FED1FDE5" modified="2012-11-28" version="1">MVHKNFKRQRRLESRLDETVRIASIVQKGMATGRSSYVEMRALDRLIKHNIRTRVSALKKSVKLSVELDELLSKIPQAVSDGYTKVLTPNGIVREGELDHLLSIDADIVMCIGMFESEKSRRGVVETLKELVEERKKLIDSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBV6</accession>
    <name>K0IBV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c00850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57035">
        <property type="protein sequence ID" value="AFU57035"/>
        <property type="gene ID" value="Ngar_c00850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00850"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="RDINACH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-85-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="196"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="307"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="411" mass="48242" checksum="B84EBF8EA7D0503F" modified="2012-11-28" version="1">MNLFLYPPPHPPAKVPETLNSSSNSDVYKKMLNYKFRLYPTKEQELLLEQTLDGCRWVYNYFLSLPSPMSEYDMNYALTELKEQHPWLRKYYHSKMLQMVAKQVAAARKVAKGRKLSYRKDSDFNSFTYNQSGFRLENNNRLSLSKIGRIRIVLHRQPVNVKQVTISRTKTGNKWYAIVACDVLRRSFSTIIRYAKPVGIDVGIAKFCHHSDNHVEDNPQFLTKMLRPLRRAHRRVSRRQIGSNNRKKAKRMLARLYERINNKRKDFLHKKSAYYASRYDLIFLERLRVMNMTKNHRLARKILDASWSAFKNMLQYKANRVVEVEPSYTSINCSRCGHPVPKSLAVRIHVCTKCGAILDRDYNSAINILKRGLESLVLLLLPVERREVTPVEIVLQQRSLKQEEAHVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC23</accession>
    <name>K0IC23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19640"/>
    <dbReference type="EnsemblBacteria" id="AFU58896">
        <property type="protein sequence ID" value="AFU58896"/>
        <property type="gene ID" value="Ngar_c19640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19640"/>
    <dbReference type="HOGENOM" id="CLU_1691592_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1962-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17029" checksum="338AA374A588CED2" modified="2012-11-28" version="1">MDRPVKEISSPIVALENDASVGNALAAMVQNNVRNMVIRAEKGSGANNMQIINDRKILEFLLSHDGRQMMSEKGLTGLYEIKVAELEMLVPKQVEPDMPARKAGELMSDISTPCLLVNAAEHPHHPDSIITPWDIVMRGFRNKDGSAAQEIDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC81</accession>
    <name>K0IC81_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c20390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20390"/>
    <dbReference type="EnsemblBacteria" id="AFU58971">
        <property type="protein sequence ID" value="AFU58971"/>
        <property type="gene ID" value="Ngar_c20390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20390"/>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="OMA" id="PHWVWVL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2037-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="447" mass="47125" checksum="4FBBAE9C1C58349F" modified="2012-11-28" version="1">MKVGEQKEPGLKRNINLFQAVMYGVGLILGAGIYVLIGDVAGIAGNAMWISFVIAAVIATFTGLSYAELSSMFPKSAAEYVFAKNAFKNNLVAFITGWLITFVAVASAAAVAIGFSGYLASFLPQFDPVLSAVALLAALSAINFIGIRESVWMNTTFTLIELAGLAIVVLAAVLLGSFAGVDYYELPPAASTLSLSVGAIIGAAGLVFFAYYGFENLANISEETKNAPRTIPKALIISIAVTTGVYILIAVSAIALVGWEALSSTGAPLALAAEKAFGRPGVTVLSAIALFATSNTVLMMLIAGSRIMYGMSRERALPAVLGRVHPATKTPWIAVVLMMLLTSAMVVFSRGSISAVANIAVFAIFMVYALVNLALIWLRHKQPELERPFRSPVRIGWFPVLAGLGFITSLAMLSQFDSGTMIAGAATVAIGLASYAAIERYRSKRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICA9</accession>
    <name>K0ICA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c20850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20850"/>
    <dbReference type="EnsemblBacteria" id="AFU59016">
        <property type="protein sequence ID" value="AFU59016"/>
        <property type="gene ID" value="Ngar_c20850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20850"/>
    <dbReference type="HOGENOM" id="CLU_116578_1_0_2"/>
    <dbReference type="OMA" id="HPNEYMG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2083-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="15140" checksum="7028C2C7BEC3ECE3" modified="2012-11-28" version="1">MLVFKKREKVQRHVIITRQAADGIITWSKTHHPNEAILILQGRNTRDAVIVDGLVIPPFAQSGPFFSGFSVHDLPYTIPNVGTAHSHPGGSNRPSLEDLNHFSGYVSIIISHPYEDENIGAYDRSGNSLEIKIVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICH5</accession>
    <name>K0ICH5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57285">
        <property type="protein sequence ID" value="AFU57285"/>
        <property type="gene ID" value="Ngar_c03370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03370"/>
    <dbReference type="HOGENOM" id="CLU_2327341_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-337-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11038" checksum="B5FB43D71881A6E3" modified="2012-11-28" version="1">MSVIKFRIPPGFNIKGKGTFFDSDEVRRRLKGKYPQMADETKKAQYVLGAITYDDTTGLVTIEINTPNTALMTEGQKQTIKNEIASWVEFMGWEADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICW1</accession>
    <name>K0ICW1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinine amidohydrolase</fullName>
            <ecNumber evidence="4">3.5.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c22660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.10" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22660"/>
    <dbReference type="EnsemblBacteria" id="AFU59196">
        <property type="protein sequence ID" value="AFU59196"/>
        <property type="gene ID" value="Ngar_c22660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22660"/>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="OMA" id="YAIEWMW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2264-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047789">
        <property type="term" value="F:creatininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="25797" checksum="148FF4EB4A6024EA" modified="2012-11-28" version="1">MSVPVFGMSEHDFRSALKKTKRAIIPVGSLEQHGSHLPVSTDSLIVEYIARLAAEKVGAFVLPVISYGISFEHKPMFNVSLRNSTLSTMICDACISLAENRIKEIIILNGHHGNMGALQYIAQELHGRLPRDVRVHTIHYWHMMKSEFDHAGEVETSLVLAIAPELVRMDRALPNSKKLSKSKAAYSSITNTPGSFPKITGNGVWGDPRKATAAKGEKWIKEVTAGLAKTITELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDG4</accession>
    <name>K0IDG4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57680">
        <property type="protein sequence ID" value="AFU57680"/>
        <property type="gene ID" value="Ngar_c07370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07370"/>
    <dbReference type="HOGENOM" id="CLU_3075470_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-735-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6038" checksum="DFBD30E68D97319F" modified="2012-11-28" version="1">MQIAAYLRGVFIDNSVQYSVVRFHFGIIFADFMIIALQSLFIVIFNRGRLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDI8</accession>
    <name>K0IDI8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57720">
        <property type="protein sequence ID" value="AFU57720"/>
        <property type="gene ID" value="Ngar_c07780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07780"/>
    <dbReference type="HOGENOM" id="CLU_2679060_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-776-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8211" checksum="230196757AA8A375" modified="2012-11-28" version="1">MQSQQPVANSNTATELVKKKKGEKKLHRGTRAHTHIVLSVSGAATDKAQNLRDGSSKRRQENHVIRQEPQTLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDU6</accession>
    <name>K0IDU6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c00380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00380"/>
    <dbReference type="EnsemblBacteria" id="AFU56988">
        <property type="protein sequence ID" value="AFU56988"/>
        <property type="gene ID" value="Ngar_c00380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.43"/>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-38-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="199"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="349"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU56988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="376" mass="42883" checksum="0AE3D0B49E9F11D1" modified="2012-11-28" version="1">MLRLITWTGLERVSTKTILVSYPDSFRLEEGKSLVESADCKIVKIFTQKYLNHSQYGIGAGKAEEIRDFVKGEEEGIQQLVVDEHLTSKQLYNLSKLVEVQAIDRERLILNIFYSRATTTEAKLQIELAEIQYEIPRVREIAKMTSGNERAGKGGMGEYTVDVKFRDLKRRMNFIREKLVEAKKKRDLYHQQRTRTQMPVVSLVGYTGSGKTTLFNLLTKEHRETSSSLFTTLSTTTRVMKFNDEKQGDLLLTDTVGFISRLPPYMIDAFKSTLEESLAAHLILLLVDASEDVQNIDIKYSSCWDVLDELKVDHAKVLVVLTKQDAVDAQKMQEVMQQLQLKEPIMIISSKTGYGIRKLKNMMVSKSRPKMVGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE15</accession>
    <name>K0IE15_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c10630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10630"/>
    <dbReference type="EnsemblBacteria" id="AFU58005">
        <property type="protein sequence ID" value="AFU58005"/>
        <property type="gene ID" value="Ngar_c10630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10630"/>
    <dbReference type="HOGENOM" id="CLU_044569_0_0_2"/>
    <dbReference type="OMA" id="IVNFHCR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1061-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="221"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="314"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="402"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="477" mass="50757" checksum="829268F9A1D6B8CE" modified="2012-11-28" version="1">MAERLKTADAGAIKRNALRLSLVAITSVFVFEFTAGIFTNSLALITDSTHALLDAVVTAILIIATTLALKPRDIDHTYGHGKIETIGGFIGGTALFVVAIFFIYEATVRISLAGPVPLVNPGMIGFAAVIYTLAVDGFRIIVLGRAMKKTAAGTTALNADFYHAFADLASTSVAFAGLWLVTAGFGHGDSVAAMILGSFLAYLSSRFAYQNAMELTDVISPKLVAKVRQAANDTEGVLGSDDIKMRRVGKEIFVEATITLPAEISFENAHDISAHVESNIAKSLAGSGLNVRPRNITVHFEPTTGNNADLPPESMIEKAASGVSGVKGVHNILVSKIGKTDSMDVSLHIQVNRSATLTEAHSIANAVEDSIRGRLKGAETITVHLEPLMPEIGGIEPVADVKMQDSIREIILGASDVKKVDRVATYRAAGNVLKIDVACAFNSDMTIEQIHERVSDIEKQIRAKYPGSIVTIHAEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM0</accession>
    <name>K0IEM0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28820"/>
    <dbReference type="EnsemblBacteria" id="AFU59801">
        <property type="protein sequence ID" value="AFU59801"/>
        <property type="gene ID" value="Ngar_c28820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28820"/>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_2"/>
    <dbReference type="OMA" id="AREENSY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2882-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="21704" checksum="D2FABABCF3711CA6" modified="2012-11-28" version="1">MSATDDLLQDHVTIRRLQAVIERCYTLLYDNKDVPFGDLVKIADIMEQFVDQFHHGKEENGYFPETEGKDHYYSEEIRKFLVEHELGRRIAKRARIHLEEFLQGKDAREPLARYLKAYSVFILDHTSKEDRFFTDVKERRSLSESEEKELKREFEHMKHECVRRSGNLVEVLAQLESAEWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM1</accession>
    <name>K0IEM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative threonyl/alanyl--tRNA ligase, SAD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02750"/>
    <dbReference type="EnsemblBacteria" id="AFU57223">
        <property type="protein sequence ID" value="AFU57223"/>
        <property type="gene ID" value="Ngar_c02750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02750"/>
    <dbReference type="HOGENOM" id="CLU_893161_0_0_2"/>
    <dbReference type="OMA" id="IACQHTA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-275-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="174"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="311" mass="33971" checksum="9F162B751DBB8A4E" modified="2012-11-28" version="1">MHDRLAHTAEHAFIGSLQKLLGQTLRVRKVEHKGSGNTAFIVIPQLDLDTVLKAESEVNLLITEGRKVVARTFPSLEKAKKNIPNLRANEERIAAAGEVRVVEIENHDVAACAMDHASNLQECDFFLVTRLSKSGSEYEVDFAVGRQAKETAVTLAAKLMRVCSELGANINTVENTAKKLRSENESNARKLKALGREKLSGIKPVTNDRVTLLKGVFENLADDQLQEFAGDKIADANNNTVVLVANVGSGEMANVVFARNEKMKGIDCNKLFKQFAGPDGRGGGKPHFVTGVIKKEAVSSVLDRIVNEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEV5</accession>
    <name>K0IEV5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59891">
        <property type="protein sequence ID" value="AFU59891"/>
        <property type="gene ID" value="Ngar_c29730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29730"/>
    <dbReference type="HOGENOM" id="CLU_200883_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2973-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8174" checksum="B00F01DBE0722482" modified="2012-11-28" version="1">MVELKILKGKKNEGLSVYLAKKSITINSEGDVPVLEVTNEYGNSVRYEISDSYRFDNLHANLWQFIKDSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF37</accession>
    <name>K0IF37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57418">
        <property type="protein sequence ID" value="AFU57418"/>
        <property type="gene ID" value="Ngar_c04740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04740"/>
    <dbReference type="HOGENOM" id="CLU_2613746_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-472-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9408" checksum="1122A014F2E91EEA" modified="2012-11-28" version="1">MEMKMKNCRSIFATYLRTKRIETEFIDLLQGRIPKSVFARHYFRPDFKDNCKKNSKDNSITASRASYSLTWQKIQHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF55</accession>
    <name>K0IF55_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminopimelate decarboxylase LysA</fullName>
            <ecNumber evidence="3">4.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="3" type="ordered locus">Ngar_c30800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30800"/>
    <dbReference type="EnsemblBacteria" id="AFU59996">
        <property type="protein sequence ID" value="AFU59996"/>
        <property type="gene ID" value="Ngar_c30800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30800"/>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_2"/>
    <dbReference type="OMA" id="QFTVCEY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="2">
        <location>
            <begin position="52"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="1">
        <location>
            <begin position="302"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="450" mass="49946" checksum="1B0B69F598127C99" modified="2012-11-28" version="1">MAENSQVQLVQKPIAAALNRFVKPVDISKLVEQYGTPLYLVDEDTLHAKARELHSAYSKFKGPVKVAYSIKANFTPAIIKAFMKDGVTFDLTSLGELHFIKQCRADPENVIYTSVTEEPEEYVEVLQSGVRRVVVSSFNGMTNLAKAASKVGGARPLTMIRVNPEVGVKAEVRASYRNGKFGVPFNGGTIDSAAKMVKHLMGSDLLKFEGFHFHLGSQITDFSCYTHALDKMDAFMTKMKKEHPAFQVNTFDIGGGTPVFYNDPVPTPAQMAENHVGKLNQLAETHGTFTLMIESGRFLVAESSMLVSRIVNTKEYNEHKIVIVDAGYHILLDAALLKQEYPQEVVPLVNSKDRTTALAPVAVKNTHLAGRLCDTYDVFPLSKVSDLNESEVGRYISFYNVGAYSVVFNMPFHCQTKPPIVMKDSDGKFRLVRKGTTYEHLFREEGGDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFQ3</accession>
    <name>K0IFQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57663">
        <property type="protein sequence ID" value="AFU57663"/>
        <property type="gene ID" value="Ngar_c07200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07200"/>
    <dbReference type="HOGENOM" id="CLU_2519873_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-718-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9950" checksum="1518FB7B6511EA88" modified="2012-11-28" version="1">MSLKDVCQQLKRYGVEIDADALRKTYPDEDQLARVERNLWQMLRRIEEERRTGMPALSPFFKVRLPCDIWTGRQRKCFSSAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFT9</accession>
    <name>K0IFT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57668">
        <property type="protein sequence ID" value="AFU57668"/>
        <property type="gene ID" value="Ngar_c07250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07250"/>
    <dbReference type="HOGENOM" id="CLU_2433699_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-723-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10355" checksum="FF99D7CDB1B6EAFF" modified="2012-11-28" version="1">MANTSFRVQTHKFSQDSIQTTLVCSKCDEVFSKEFPLDLEGQTIEFKCPVCGAPGEADLPYKSAEEREELEEDFEEVEEEESGEEFEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG24</accession>
    <name>K0IG24_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08160"/>
    <dbReference type="EnsemblBacteria" id="AFU57758">
        <property type="protein sequence ID" value="AFU57758"/>
        <property type="gene ID" value="Ngar_c08160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08160"/>
    <dbReference type="HOGENOM" id="CLU_032903_4_6_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-814-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="11127" checksum="B5581DC4CBBDE36D" modified="2012-11-28" version="1">MQNYKFRLYPTYEQKLVLEQTLDGCRWVYNYLLDKNMSEYDMNYALTELKEQHPWLCKYYYHSKMLQMVAKQLAAAARKTASGGKLSVIQKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG50</accession>
    <name>K0IG50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58765">
        <property type="protein sequence ID" value="AFU58765"/>
        <property type="gene ID" value="Ngar_c18320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18320"/>
    <dbReference type="HOGENOM" id="CLU_2327344_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1830-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="10672" checksum="1F380A929D7D3BF9" modified="2012-11-28" version="1">MVSLFRARAATALAISVAVDALDYVAAPLFATPVIGDISDAIVTSVLYAITRSKRSALINMAEFVPLVGDFVPVYTISTLMWIHSELKKEKVVMKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG57</accession>
    <name>K0IG57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, N-terminal subunit</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tktA</name>
        <name evidence="2" type="ordered locus">Ngar_c34770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34770"/>
    <dbReference type="EnsemblBacteria" id="AFU60391">
        <property type="protein sequence ID" value="AFU60391"/>
        <property type="gene ID" value="Ngar_c34770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3478"/>
    <dbReference type="HOGENOM" id="CLU_490605_0_0_2"/>
    <dbReference type="OMA" id="CPGVEFC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="546" mass="60920" checksum="D54A60179F65AB26" modified="2012-11-28" version="1">MGFNMRYLDLKRRIRDVRMWAIQGIAEAGSGHPGASFSAAEIMGTLYFRKMRHDPSNPSWEERDYFINSKAHSAPGFYSTLAVAGYFAPEEVKTLRKLGSRLQGHPVRYSDHQKHHSVPGVEYSGGSEGIGLSVGIGIALANKLDGKKNKVFVLIGDGESNEGQIWEASMAAGKFKLDNLVAILDRNRIQQDGFTEDIMPLDPTKDKWAAFNWQVFEVDGHKVEQLVDALNKAARVHDKPVMIIANTIKGNGIRHMANNPQWHGKAPPKRHTEVLLEELDSECLIAPSIIAGERENYEDKIRKVEREGVDMIHLDVMDGRFVPNTTFFADTIKKLRTSTSLPFDAHLMIERPLEQIQEYIDARCDIITVHAEACTENEFREIQERLIDAGISPGIAINPGTAVPKWLYGCLHDLDVIIVMSVNPGFAGQKFIPEVLPKMVAVNKELREHGFRGYIEADGGIDATTLQYAYDAGARIFVAGAAVYGGGDIHSAVIQLRHKAAVALEKRLLNHATQLNIRPDWMKARKHILIPYANELGIEEELHAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG77</accession>
    <name>K0IG77_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58795">
        <property type="protein sequence ID" value="AFU58795"/>
        <property type="gene ID" value="Ngar_c18630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18630"/>
    <dbReference type="HOGENOM" id="CLU_2821039_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1861-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7576" checksum="922FD87505D0D554" modified="2012-11-28" version="1">MKAIKANRQAQSYKSDFEQEMIRLMRENNKSLQAIDDNVRKLEKNRNPARAKLQGKAKVGGKGIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG79</accession>
    <name>K0IG79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase, IS605 OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c08810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57823">
        <property type="protein sequence ID" value="AFU57823"/>
        <property type="gene ID" value="Ngar_c08810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08810"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="DRRRDWH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-879-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="136"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="349" mass="40860" checksum="6C7788A7F4683588" modified="2012-11-28" version="1">MYIDKNMSEYDMNYALTELKEQHPWLRKYYHSKMLQMVAKQVAAAARKVVVAAATGKLKYRKGDDYNAFTYNQSGFKIEEDGKLYLSKIGRIRIVLHRQPVNVKQVTVCRKNGKWYADVACETLRRSFSTIIRYRKPVGIDVGITKFCHDSDNHVVEDNPQFLTKMLKPLRKAHRRVSRRQIGSNNRKKAKRMLARLYERIHNKRRDFLHKLSAYYASHYDLIFLERLKVLNLTKNHRLARKILDASWSTFKNMLQYKANRVVEVEPAYTSVDCSRCCYPVPKSLAVRTHVCTECGAVLDRDYNASLNILKRGLESLMMLLPVERREVTPVEIAMQSRKQEEAHVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGG5</accession>
    <name>K0IGG5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58895">
        <property type="protein sequence ID" value="AFU58895"/>
        <property type="gene ID" value="Ngar_c19630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19630"/>
    <dbReference type="HOGENOM" id="CLU_843633_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1961-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="329" mass="36464" checksum="43EC94F367B1B7E7" modified="2012-11-28" version="1">MIEVRPFQISSSQKYPSDGYVELLQNLHSSGRSCKILLQCDKSQTYPDKLSVRYFIDIDDHDKRQVVNSLSKMPVQILTGSPRPRHYGYFAELKLRRPYPLPLIDHSSKGENNSINPFSSAAGNIAESLYGVPSMLEIVFKADTHAAARIWSYLEKFEKKLPSSDILSQLASIGTGFASEAARFGSTKKGASMGPAKQDKELSLFEKNLLDAMKTKARSHAFFLTKITVFGESSGHVENIAKQFPNWHNGFSARVKKVDQKEGPLPGAAPPALSRSRASLLFSFHEYRLAVLSMEEILSMISVHPSPQQSAHFEQGVSRPGADSSMPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGH2</accession>
    <name>K0IGH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphate ABC transporter, periplasmic phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c35780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35780"/>
    <dbReference type="EnsemblBacteria" id="AFU60491">
        <property type="protein sequence ID" value="AFU60491"/>
        <property type="gene ID" value="Ngar_c35780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35780"/>
    <dbReference type="HOGENOM" id="CLU_978665_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3579-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="3">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="284" mass="30902" checksum="8B5AC6EA794ACAE4" modified="2012-11-28" version="1">MSKVSPEWADQVGKGKSVQRPTGISAPGNEGVSSSIKSTPYAIGYIEFHYALTTGMPYAYLQNQEGNFIELSIDSVRTAIAASAGSLPNGEKSWEHVSTTDAPGEDSYPISSFSYLLLYKELSTNPRIDSMDKAIALVDFAEWAITDGQQFADDLAYVPLPEEAVQINEETLESITYNGQPVLAEERVTSTDSLGLFSPIIAASIILAIAAGSAIYIWRKRRGSLAPKEISTEPRERRETRDKISYPLLRGTLAGDRIFRFIVISAAGYMMLLLGLVAVSIFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS4</accession>
    <name>K0IGS4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21090"/>
    <dbReference type="EnsemblBacteria" id="AFU59040">
        <property type="protein sequence ID" value="AFU59040"/>
        <property type="gene ID" value="Ngar_c21090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21090"/>
    <dbReference type="HOGENOM" id="CLU_1363593_0_0_2"/>
    <dbReference type="OMA" id="ITEDYAF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2107-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="23643" checksum="34DA307A64753976" modified="2012-11-28" version="1">MTTAAIYLAHLNPMTRAHESIISMLKQEHRVYVFPVRFIKDGREINTKSFPFSYELRKSMVESVFGDSVSVLPDYTFYAPYIKYMPPLLSSRSWKLRNQIIAQIKEEKFVSYTGDKAERLMLKAYRLNPLKADRLEISASSVKEELYRQAIEGGNDEKWRDKVPEPVAEIIKKNWDVIEKFARMEDGTMRKVGMKFPKEGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH16</accession>
    <name>K0IH16_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mercuric reductase, MerA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59150">
        <property type="protein sequence ID" value="AFU59150"/>
        <property type="gene ID" value="Ngar_c22200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22200"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2199"/>
    <dbReference type="HOGENOM" id="CLU_016755_4_2_2"/>
    <dbReference type="OMA" id="SNMARRW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2218-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="20831" checksum="2CF23022A3BEFA6D" modified="2012-11-28" version="1">MASKDAKYDLIIIGGGAAAFSAAIKADMHNVKTALVERAALGETCVNVGCVPSKNLLGTAEVLHSVKELPYPYILPCDSGFDFAKTISDKDRLVRSLRKQKYQDVVSGLKNIELIKASAAFVSKKRIRLDNGRTLEADKFILAAGSSPSVPPFKGIDEVDYLTSNEALSLKAVFNDRHWRQGFGLGIRTNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH70</accession>
    <name>K0IH70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58188">
        <property type="protein sequence ID" value="AFU58188"/>
        <property type="gene ID" value="Ngar_c12480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12480"/>
    <dbReference type="HOGENOM" id="CLU_1773258_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1246-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16700" checksum="484DA01B1D389E13" modified="2012-11-28" version="1">MKLATKETPVFQEGIVAYLDILGFSRKKDEDEVDRCFTDFPNPLIYAAKIFDKVRFSMFSDCAVLAADQKDAADLIATIRSAFRNWSFDGILVRGSICLGTYVERKSIFYETAPPNFRGVYHFGYWPCKSCEAGRKEASRVAFHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH82</accession>
    <name>K0IH82_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="3 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">adkA</name>
        <name evidence="10" type="ordered locus">Ngar_c02030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="3 8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02030"/>
    <dbReference type="EnsemblBacteria" id="AFU57152">
        <property type="protein sequence ID" value="AFU57152"/>
        <property type="gene ID" value="Ngar_c02030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02030"/>
    <dbReference type="HOGENOM" id="CLU_119371_0_0_2"/>
    <dbReference type="OMA" id="HRDEMRK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="21924" checksum="4126DF02ECFE1DBD" modified="2012-11-28" version="1">MAENNKRAVIVGIPGVGKTTVITRAAEMLNEKRKTTVVVFGTVMFEEAKKMGLKSRDEMRRMPVEEQRRLQEMAAQRIAEMRDSIVLIDTHLFINTAEGYYPGLPMRLLNIMKPTNMIMVAADANEIAERRRTDQTRQRDIASAENIQKELDISRVMVSSCSILTGAPFAIIMNNDGQVDEAAANIAKILLVGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA0</accession>
    <name>K0IHA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23600"/>
    <dbReference type="EnsemblBacteria" id="AFU59285">
        <property type="protein sequence ID" value="AFU59285"/>
        <property type="gene ID" value="Ngar_c23600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2335"/>
    <dbReference type="HOGENOM" id="CLU_881675_0_0_2"/>
    <dbReference type="OMA" id="DCIFCLA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2358-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="340" mass="37479" checksum="7F2765EC26ADC2EA" modified="2012-11-28" version="1">MSALLKDRVWTMLSEVAKRGVYPLHGNKLGIYRIPIEITEKSDISSIMNDLRSSGFKMDTHADRIYITYKWTEKGNDPITGEDLSADLNVTVEIVTGEVVDLIYQIRQLEYFGDPYWIKNYRQKADQNAKMVIDTIIRNTRIGDKLLAHWQKVEKLTMEQALKKLEELTPLAKNPKARSATAPPPAGPSAAPRPAAAAPQMPPPPAIPAAPSAPAAGGPTTISLSGTGTNYGKVEGPIDPKFKEKRQQVGTYQGIKVWGPYDAPGQLGIWGDYVCIDFDICVADGACIEACPVNVYEWLQTPGHPASDKKAFMIREKDCIFCMACENVCPPQAVKIFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA3</accession>
    <name>K0IHA3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59290">
        <property type="protein sequence ID" value="AFU59290"/>
        <property type="gene ID" value="Ngar_c23650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23650"/>
    <dbReference type="HOGENOM" id="CLU_2550383_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2363-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8740" checksum="18C7F2B56564D7DF" modified="2012-11-28" version="1">MRDAAGVIVRLSPYTPNAMSLIPYTKGAIAIIKATSKTPKKGEIKAMPAMTTVARPRQYLLLLTSWVSSISYSGQNAGNAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR9</accession>
    <name>K0IHR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58493">
        <property type="protein sequence ID" value="AFU58493"/>
        <property type="gene ID" value="Ngar_c15590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15590"/>
    <dbReference type="HOGENOM" id="CLU_3075477_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1557-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6125" checksum="58AE0634A7EF04C7" modified="2012-11-28" version="1">MSTTFFSYDRYRTLLLDFVLTGQFHSHQCPKCGVVYDCDQHGCLKFQRGCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ1</accession>
    <name>K0IHZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16250"/>
    <dbReference type="EnsemblBacteria" id="AFU58558">
        <property type="protein sequence ID" value="AFU58558"/>
        <property type="gene ID" value="Ngar_c16250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16250"/>
    <dbReference type="HOGENOM" id="CLU_2985800_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1623-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6468" checksum="680084DE22B16D07" modified="2012-11-28" version="1">MTVRGKVVEQTTNGADEHIDKMAKKYVGLDKYPGHAPGEKRVLLKIKPERVSHIKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0II15</accession>
    <name>K0II15_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57612">
        <property type="protein sequence ID" value="AFU57612"/>
        <property type="gene ID" value="Ngar_c06690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06690"/>
    <dbReference type="HOGENOM" id="CLU_2968566_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-667-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6618" checksum="4590F773E7FC7414" modified="2012-11-28" version="1">MQVTVLIQMINNEKIRKFRKGIMIAFAVIALIVGIMLILNSFNDVFGRLRKLASTGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0II23</accession>
    <name>K0II23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59575">
        <property type="protein sequence ID" value="AFU59575"/>
        <property type="gene ID" value="Ngar_c26530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26530"/>
    <dbReference type="HOGENOM" id="CLU_034350_0_0_2"/>
    <dbReference type="OMA" id="MEMPERR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2653-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="465" mass="50625" checksum="6B0620CE70D86926" modified="2012-11-28" version="1">MEMPERRKILASVLTLAFFVTLMISALALPSAFAHGGHQPPPADFGGKKASLFVSLEPLVVTTSTDPVYINARFFDENTNENFKEVTYRVYFKKDGNEVPIVTEGGQFGGQGFFYDPEGDLQIKIVPKDSETAVARGEAEPQFGGIWNRGGPVVVEGPIFTDPGLYNLFVEIYTVGTTRTQVEPVLQYDVWVTPGREEVIDVEGQQIKVRNYYGAIDSSNYDEETKTIEFSMPFDWTSDMPSRIGMLHTEVFIPKALADFNKQSLNATVNGISVPVAVDTYTPENTIVHFTISKQNLINIAEKVKSENLTPDKAVFALSPPTTEVKVAQVTTDSQNYKVALTWPEQVFPGQPVTFGIRVTDKSDQPLSAATYELVILDKDGNEVTRAGGVTTPEGVSSQDMTFASQGSFTVRVDKINASSESVQSSLSVVPEFPVGIASIAAALAIGGIIVAAKRISLFATGKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0II88</accession>
    <name>K0II88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57692">
        <property type="protein sequence ID" value="AFU57692"/>
        <property type="gene ID" value="Ngar_c07490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07490"/>
    <dbReference type="HOGENOM" id="CLU_2353299_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-747-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="10951" checksum="1B7850ABA7E8BCA5" modified="2012-11-28" version="1">MSYLICTGNEAVSKEASIIINDWRPLRIDSRGWVVVVKNVNGLDNVKEFYPAGEWKKAYEYLKIQSELRALLFSELTAEQINEYRMAIGLPPSEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF1</accession>
    <name>K0IIF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59690">
        <property type="protein sequence ID" value="AFU59690"/>
        <property type="gene ID" value="Ngar_c27690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27690"/>
    <dbReference type="HOGENOM" id="CLU_2784240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2769-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7521" checksum="177C839AEA700C85" modified="2012-11-28" version="1">MSDIAVQESHKDDTGLFAAAFSRLANTDGSILIETPPHGPRGKIYEIYMQSKLAAAKRENVEGQFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF5</accession>
    <name>K0IIF5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name evidence="3" type="ordered locus">Ngar_c08900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08900"/>
    <dbReference type="EnsemblBacteria" id="AFU57832">
        <property type="protein sequence ID" value="AFU57832"/>
        <property type="gene ID" value="Ngar_c08900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.848"/>
    <dbReference type="HOGENOM" id="CLU_046932_2_1_2"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20094" checksum="8E671E414C2ED566" modified="2012-11-28" version="1">MRKGFVLWLTGLPGSGKTTISGILKQQLQSRGLQVEILDGDEVRKNLSPNLGFSKEDREIHAKRVAYVSQLLARNGINVIVALISPYRSFRDNARAMIGEGFFEVWVKASPETCRQRDPKGLYKKASAGQISNLTGIQDTYEEPLNPELVVDTEARNVNECVNMILGLLKQYRYLSNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH2</accession>
    <name>K0IIH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c18960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58828">
        <property type="protein sequence ID" value="AFU58828"/>
        <property type="gene ID" value="Ngar_c18960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1880"/>
    <dbReference type="HOGENOM" id="CLU_076510_0_0_2"/>
    <dbReference type="OMA" id="EIMFLPW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1894-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027561">
        <property type="entry name" value="Thauma_sortase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04297">
        <property type="entry name" value="thauma_sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="348" mass="38470" checksum="7443FDEDBF95A1ED" modified="2012-11-28" version="1">MSGDKAVASGEAAGYTIFGINSSIAATIILIVPIIYTIIVYPDSFSLSWNEGRGGFLFAMAFIAAELVGLRYRISKTRFLIVVGLAALTTTYFVALPYGLSEYIKNGATYYNVSLELSWIWMWDFVVMFVYVTSSLVILFGKKWYKIAPAGAIYLAGSAVILALDAFFPFDSLGPLQFIVPIYLIIDEATINFIDDYVTNVGPEDPNHPANPVRATGNLLILNGLHGPFALQVFWPSAGVHSMIIYTLVMLAFLLKMDLPLKRKLIYFAIGTFGTVAVNVIRITSLSLYALVVTTNVREWEAFHSVAGEIMFLPWLGIYLGIVMFVENKRMRRMQAESATPASSRPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL3</accession>
    <name>K0IIL3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58903">
        <property type="protein sequence ID" value="AFU58903"/>
        <property type="gene ID" value="Ngar_c19710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19710"/>
    <dbReference type="HOGENOM" id="CLU_1458237_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1969-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="20060" checksum="394B85AED5AC23C7" modified="2012-11-28" version="1">MQCVNRHSRFWPILDVLSERRYAAILIVSGLAYGILYMVVVGVVSYVPGLHSVTGPYPIIRFTSLGISAIIAGNVFFFIFYGAIAFLAASSFLVGLNISLMFYARRMTRACRMNRFSKSKGLLGLLPAFFTSFSCCGTGPLTLAIGSAAFSSLSLYSQYMAPMTIAVLVAGTYMMSSKVSKTEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM8</accession>
    <name>K0IIM8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aconitate hydratase</fullName>
            <ecNumber evidence="6">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aco</name>
        <name evidence="6" type="ordered locus">Ngar_c28500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28500"/>
    <dbReference type="EnsemblBacteria" id="AFU59770">
        <property type="protein sequence ID" value="AFU59770"/>
        <property type="gene ID" value="Ngar_c28500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28500"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2820"/>
    <dbReference type="HOGENOM" id="CLU_006714_2_3_2"/>
    <dbReference type="OMA" id="GCIGMGQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="5">
        <location>
            <begin position="515"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="646" mass="69932" checksum="66377651DB8905F2" modified="2012-11-28" version="1">MASLNLAQKIISAHLADGKMEPGQEIGLKVDRVLMQDATGTMACLQFEAMGIPRVKVEHAAIYVDHNILQTGFENGDDHRFLQTFAAKYGIHYSKPGNGICHQVNLERFSIPGKLLIGSDSHTPTAGGAGMMAIGVGGLDVAVAMAGAPFYTKMPKIVGVKLTGRLRPWVTAKDVILEMLRRLTVKGGVGKIFEYYGEGIKSLGVPQRGTICNMGAELGATTSLFESDEITQDYMTRQGRPQDYKRIAADPGCSYDENMEINLSELEPMIALPGSPDAVHKVRDVQGQDVHQVLIGSCTNSSYIEIMTVAHVLKGKKVHPNVTMAINPGSKQVLETVARDGSIYNIIASGARLLESGCQGCIGMGSAPGTDWVSIRSFNRNWPGRSGTKDDKVYLTSPEVCVACAITGKITDPRDLGEYPNIPWPDKFVIDDSGIVPPAPAQYADTLEISRGPNIRPLPLRQPMEAILQGEVLIRVGDNISTDAIMPAGAKILPLRSNVPAISEYVFYWLDPDFAKRAKEKHGGFIVGGENYGQGSSREHAALAPMYLGVKGVIAKSFARIHRANLINFGIIPFEFQNASDFDLLAQGTPVTIENIVGNLKQGSKTMEATTDKDKKITLKVDLTPRQRDVLVAGGLLNYIRSTTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP7</accession>
    <name>K0IIP7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58943">
        <property type="protein sequence ID" value="AFU58943"/>
        <property type="gene ID" value="Ngar_c20110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20110"/>
    <dbReference type="HOGENOM" id="CLU_2550380_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2009-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9365" checksum="CDE00F87E2611024" modified="2012-11-28" version="1">MSATENHPLAATSKKGKLRNFIEGKLMDAQKSGQVSVVIPRFPDYYGSNVVNRLMAPIFFRIQEYFSESFVQQEICKFVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU8</accession>
    <name>K0IIU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dihydroorotate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c29720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29720"/>
    <dbReference type="EnsemblBacteria" id="AFU59890">
        <property type="protein sequence ID" value="AFU59890"/>
        <property type="gene ID" value="Ngar_c29720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2945"/>
    <dbReference type="HOGENOM" id="CLU_661598_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2972-MON"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="4">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="344" mass="38244" checksum="30AAEB034C8E1C03" modified="2012-11-28" version="1">MTDKFRQNASYFDPGDQLAVEIGNYKLKGPVGLAAGFDKNCDVLEPTSYVFGFLNPGSVLKNPRAGNPQRPKSEGTIRIAVDDEREAIINAQGYPHKGLDYTLRNLKKFSEGRRGNAKILLNFSGITDTYTEDAVLDSCKEILTRTAPYVDFGFEENRTSPNTDFNKVLQTPEFTKKMIDLMNAHMPGKVKASKISPYTRLPPSDEETQAKLKSIKVFYENGGQVVTLGNTRPVDTKTAKITKNFARGVAGESGRPLLPYMLKLVQDVHRAFPDLAIIACGGIFSGEDAWKAYESGATLVSLYTVLTFYGFGVVRDIHDTLKKKLGKEETLQSFMEKRDSRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ4</accession>
    <name>K0IIZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58107">
        <property type="protein sequence ID" value="AFU58107"/>
        <property type="gene ID" value="Ngar_c11670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11670"/>
    <dbReference type="HOGENOM" id="CLU_938813_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1165-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="296" mass="34831" checksum="371187EF869C4D19" modified="2012-11-28" version="1">MENVWFAGISSKRYVIYQKYEHNDNLKILKASSHGLKHLLNPFPCTGDDNTWHEQLWIDILNHHHGKVSFEELNEKYGNAYAMSELVISTTNVMRRFDRLNKGRSYSKKIKPFNFCIVGVGNIADNETGEVIKPVSPYRKDAYQCAFDEFIDYNSKKTLKGQKYWRQFNDYFWEYLNHPEAKFDGDTGVLSRKHVKISSVVHIGKESNELDDTEVLGIGKETYTTYVSYVELIMQHRELILNLRPKDAAPFGIMKEVLRNVKRSIMNKTLWRLSRKTKVRLLKIIERHLYTPMTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ30</accession>
    <name>K0IJ30_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31040"/>
    <dbReference type="EnsemblBacteria" id="AFU60020">
        <property type="protein sequence ID" value="AFU60020"/>
        <property type="gene ID" value="Ngar_c31040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31040"/>
    <dbReference type="HOGENOM" id="CLU_1976606_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3104-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="14550" checksum="A11A7D77C37485CC" modified="2012-11-28" version="1">MSTGRRKFKFIMTPHVHHWDSMMIFEETTKSLFTSDLFIQPGDNKPVSSDDLSESMVKLYQAVGIFASEQPVRQTVQRLARLKPEMVYPMHGSCFDSSMFPKYEDALMKNQFAFTNMLLGQKLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ41</accession>
    <name>K0IJ41_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalt transporter family protein, subunit CbtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbtA</name>
        <name evidence="2" type="ordered locus">Ngar_c12270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58167">
        <property type="protein sequence ID" value="AFU58167"/>
        <property type="gene ID" value="Ngar_c12270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12270"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1177"/>
    <dbReference type="HOGENOM" id="CLU_090632_0_0_2"/>
    <dbReference type="OMA" id="VPYLKYP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="242" mass="26111" checksum="290AF87EE22C8B4E" modified="2012-11-28" version="1">MKTITFIAITLISGAIAGTILGAVNQVVVEPYIERAIELEMQNAAQNGEIINPIEFAAYRFWQRGGEVAAGTILGLSLGSLFGIVFAYGRGSVPGSSNKKKALVIAGIMWFTLFLIPALKYPANPPAVGDPDTILYRQGLYLAFLAISGFSALGLAFLYRRLGATMKAKKALIPAIYAVIMAGTYFAMPPNPDPISAPMDLVISFRIASAFTISMFWGLLGITLGAFWDKLRPHETARISMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ43</accession>
    <name>K0IJ43_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58172">
        <property type="protein sequence ID" value="AFU58172"/>
        <property type="gene ID" value="Ngar_c12320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12320"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1230-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11749" checksum="8AC7E0681FD1F3D3" modified="2012-11-28" version="1">MMSERKNNRGKIQIMGDVLELATSGIKKTHIMYKANLSYEQVHLYLSELIEKNLIAQDTSQNGVVYRTTDKGREFLLYYTRIVEFLEEPRVELSTPYVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ50</accession>
    <name>K0IJ50_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c12570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12570"/>
    <dbReference type="EnsemblBacteria" id="AFU58197">
        <property type="protein sequence ID" value="AFU58197"/>
        <property type="gene ID" value="Ngar_c12570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12570"/>
    <dbReference type="HOGENOM" id="CLU_055690_5_0_2"/>
    <dbReference type="OMA" id="QGGPLCS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1255-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11406" checksum="EC83054A9AC0FC42" modified="2012-11-28" version="1">MPENNNNFQYVSSVDEVSSGHSKAFSITGERGKIEIALFNLGQFYAISNICVHKGGPLSKGALEGDIVTCPWHGWKYFIKNGKSPHKGGDSISSYPCGFLEDGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ70</accession>
    <name>K0IJ70_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58262">
        <property type="protein sequence ID" value="AFU58262"/>
        <property type="gene ID" value="Ngar_c13240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13240"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1322-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9601" checksum="8C750BF17A56883B" modified="2012-11-28" version="1">MKKRSSPDIIATILEAANGGIGKTRLLTKANLTSTQLKKYVNLLLEKQLLAQCQDRSSNHATYKTTGLGLQYLALYNSIRSVTYINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ74</accession>
    <name>K0IJ74_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22230"/>
    <dbReference type="EnsemblBacteria" id="AFU59153">
        <property type="protein sequence ID" value="AFU59153"/>
        <property type="gene ID" value="Ngar_c22230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2202"/>
    <dbReference type="HOGENOM" id="CLU_1222478_0_0_2"/>
    <dbReference type="OMA" id="CQDVIDV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2221-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="24750" checksum="A00DD715BBA4F119" modified="2012-11-28" version="1">MIAAMQDMGNVGSIAIDFINKSLDTKCFRYVSPPYPNYVVDKGGHIDFQQEQWEYRYGNGIIVFGGGVGQPQTNQELYELCQDVIDVAKSYSVQLVYTLGAFHTDRNYGKNPRTLVTTTSRELTDQIARLGLELTPGSSMITGFNGLILGYAKKNNMQGIGLYAEIDDPQVPQYRSAKSLLVSLEKLTYQKFKGMEELDEIAGAIDSELDRMRGSGDSLYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ84</accession>
    <name>K0IJ84_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60065">
        <property type="protein sequence ID" value="AFU60065"/>
        <property type="gene ID" value="Ngar_c31490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31490"/>
    <dbReference type="HOGENOM" id="CLU_1006918_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3149-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="30635" checksum="9CCA3A62A03605F1" modified="2012-11-28" version="1">MGEAIGQSAQDHEVLWEGIVKIDPSISAHMPEAIEAGGSLKLFTITDTSFPYGDNAQLDNHDLLADFPNEISVYVVGGKMLEYMKCSVIKQYQFSKVQKSSYFKRKKQDTNDNYSAKKIVAKKGFLLSPVDAPASQHPVGCLASVKVSNEYGESLIFEKTGLVIFASGSKTSEITFTNQKRSVTVVFVASNEKPFLAYMRSKPLLVKLLCDSNGIKTEKILQEEGQDMPSRQKVEDPLKILKVRLAKGEISAEEYNKLRKLIADDEEKVGQGSNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA6</accession>
    <name>K0IJA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="12">6.3.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">carB</name>
        <name evidence="12" type="ordered locus">Ngar_c22480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="12"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22480"/>
    <dbReference type="EnsemblBacteria" id="AFU59178">
        <property type="protein sequence ID" value="AFU59178"/>
        <property type="gene ID" value="Ngar_c22480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2228"/>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_2"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="97"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="646"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="11">
        <location>
            <begin position="904"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU59178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116455" checksum="C24DFE2F6FCE0080" modified="2012-11-28" version="1">MAEEGVKSVLINPNIATIQTDTRFADKVYPVPINVATVEKVIQMEKPDSIMLGFGGQTALNCGVALHEQGILEKYGMRVLGTQIHGIEITEDRQKFKDAMIKSDVPVLQSYAVNSLQEAFKAAKEIGYPVIIRVAYTLGGRGGGVAYNEYELQEIAQRGLNLSMVHQILIERYVGHWKQIEYEVMRDYKGNSVIVCNMENVLSMRVHTGDNIVIAPSQTLNNYEYHMLRSAAIRATSYCGIVGECNIQFGLDPQSEEYTAIEINARLSRSSALASKATGYPLAYMAAKIGLGYTLPELINRITKATTACFEPSLDYVVLKMPRWDFSKFELVKRKLGSAMKSVGEVMAIGRTFEEVVQKAIRMCDMGKDGLVANANSPPPPAPEDIERIEQALIHPNDEIIFHVVQAMKAGLSIERIYQLSFIDPWFLVKIKNIVDMEAQLRKTTFDENLVRKAKKLGFSDRQIARCQNLDEMQVRAFREKFGIKPVVKQIDTLAAEWPAKTNYLYLTYGGSEDDVKVESNNGKSSRMIVLGAGPYRIGSSVEFDWGTVNMVWGLKENGVKEISVINCNPETVSTDYDICDRLYFEELTLERVLDICGKENPTGVVTCVGGQTANNLTPKLAKNGIKIIGTSAEDVDRAEDRSKFGQLLDTLGIKQPAWRKFTSLTEAKEFADTVGFPVLVRPSYVLSGAAMKVVWGEQQLEQFLTDATNVSPDHPVVISKFLQDAAEVEVDAVSDGNDVIIGSVIEHIDNAGVHSGDAMMSIPPWRLERETIDTIVDNSVKIGKALNVKGPFNIQYLVKNGEVSVIEANVRASRSMPFVSKFVGFNLINLAAKAMTGRKLPPAAKDLWLKTTGFGIKVPQFSFMQLEGADVVLGVEMQSTGEVACFGNTFYDALSKAYMAAGYSLPLSGSALVTVGGPKNKEMLLPIVSLISSMGYKIMATEHTAEFMENNNFKDVQLVYKISEPDRKPNIADLLYERKIDFIINIPATSTIEKYVGMLYDEYQIRRKAVEMGIPVLTTIEAASSFTKTLQWLSSNTPTLAPLRNYVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC1</accession>
    <name>K0IJC1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58357">
        <property type="protein sequence ID" value="AFU58357"/>
        <property type="gene ID" value="Ngar_c14210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14210"/>
    <dbReference type="HOGENOM" id="CLU_1811513_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1419-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="13692" checksum="A74AC02EEDB5F3FA" modified="2012-11-28" version="1">MMNKDIYVKSLAPIAIVSVVFSAADGANTSLFDILSSILHYFGIEIHGNEIELNGHEVNSNQNTSLAKGGDGSNGVAIGGDGGNGGDGGDGVGIGGLPGIGIGGNGGDGGDGGDANANSGNTANGKDGQDGKDGVSMSGVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD8</accession>
    <name>K0IJD8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59243">
        <property type="protein sequence ID" value="AFU59243"/>
        <property type="gene ID" value="Ngar_c23170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23170"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2315-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11398" checksum="BCA4705E6E410A37" modified="2012-11-28" version="1">MKNRSRYEVIAAILKSVNKEETRTKIMYKAMLSNDQCKLYLDSLIKSGLVHEVNNGDKTLYKITPKGSRFLSYYDQMKELLPVGIEENLADEYYHLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL8</accession>
    <name>K0IJL8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59398">
        <property type="protein sequence ID" value="AFU59398"/>
        <property type="gene ID" value="Ngar_c24750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24750"/>
    <dbReference type="HOGENOM" id="CLU_211863_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2473-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6360" checksum="E0702591D6334DAB" modified="2012-11-28" version="1">MKGRDAQYYEETLRLLSEILATLKENNSMLKEHNSVVSSIDERVRRIGVNTSNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM9</accession>
    <name>K0IJM9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60255">
        <property type="protein sequence ID" value="AFU60255"/>
        <property type="gene ID" value="Ngar_c33400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33400"/>
    <dbReference type="HOGENOM" id="CLU_3227954_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3340-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="43" mass="5161" checksum="D79CC89137D84AD2" modified="2012-11-28" version="1">MYPEVQRRVEYFLNEKGMALKSVLEQLAAFSIQNYPDQIFHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJY3</accession>
    <name>K0IJY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60425">
        <property type="protein sequence ID" value="AFU60425"/>
        <property type="gene ID" value="Ngar_c35120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35120"/>
    <dbReference type="HOGENOM" id="CLU_2476125_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3513-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9805" checksum="E816F104A16B930D" modified="2012-11-28" version="1">MGQVYEIHKYRGESFLYVVARTNKHSENYVRGDVEKMNAMLTPEMRSEGVRYVFALGTVDSMGKKTGDRTRKKDKSILDPEGAAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE2</accession>
    <name>K0IKE2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">polB2</name>
        <name evidence="8" type="ordered locus">Ngar_c27820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27820"/>
    <dbReference type="EnsemblBacteria" id="AFU59703">
        <property type="protein sequence ID" value="AFU59703"/>
        <property type="gene ID" value="Ngar_c27820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27820"/>
    <dbReference type="HOGENOM" id="CLU_000203_6_2_2"/>
    <dbReference type="OMA" id="GYTQNTQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="350"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="753" mass="86952" checksum="C2249D6EA35577E8" modified="2012-11-28" version="1">MTVSGWLFDSYTLGDRMIFWILTESGRAIKLEDQWTHSFYVASDNLKGIAKNKELAGFIKGIEITSKYERLTDRVKSELLKITLADSRKAEMLANRIWQSGDYGQFRLYNVDLLPAQSYFYEHDLFPLAFCKVKPLRSRLQWEVQDDVWLTDYRLPDFRTIRLDIKLQREGRLPSFTDRIKSVSIKKNDDDTTIDIEKQSEAEIIQELISTVTELDPDFVLLHDGDAFVFPYLIRRAEMNGIDLLLNREKLKVSMPSYEGTSYVSYGKIHFKPATVPLLGRIHLDFSNSFVYDESGMQGFFEVARICRMPLHTAFRASIGKCLSSLQFYHAIKNDRLVPWKPDEAEHFKTLEELLLADRGGLILVPMIGVHEKVAEFDFVSLYPNIMYKKNVSAETISCNCCIDSDRRVPELNFNTCKQRTGIVPTALEIVIKKRSKYKQLKKAAKDSKSKAIYDSRQNALKWINVTSFGYLGFNNAKFGRIDSHQAVCAYDRQTLLRAVKVAEKQGFRVLHGIVDSLWVQKRDASDDDYLKLKQDIEDATGFEISFEGEYNWVVFLPSKRNEKLPVPNRYFGVFTDGSIKVRGLEARRHDTPPLFSKFQQEALKIMAKGKTIHEVKALMPEVKNLFNQYVLRLKEGRVLLEELMFTKQLSKDSDQFENRNTAEISSIHQLSEEGKPLKAGQVLRYIVTDYYQKKSKQRTVPEELIDGRTTYDAKRYVELLAETCNSITEPFGYELQINEEGQDLMGFPYSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF0</accession>
    <name>K0IKF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58882">
        <property type="protein sequence ID" value="AFU58882"/>
        <property type="gene ID" value="Ngar_c19500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19500"/>
    <dbReference type="HOGENOM" id="CLU_361187_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1948-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="774" mass="88338" checksum="254CAA97719CADE4" modified="2012-11-28" version="1">MKLSITNNCTNENENKIKATATEAVRIYKPTLLKEDPLPLDRAELSYAEKLLQASSDGLIPVKLEEDVVIQRISHDLYASAESGFRELYNNEARACRIARNHYYNDDASPRIEVTLVPSERKLVIHGIDSMGMSQEKFLTVYTVLGRSDNFDSKEVGQFGCGRASYVTLSDIMVLETYSRETGEKYAVMGKNGIGYNVLPPPTDLNEYGTRITLTLRHGISIVNLVKYMMKVCMFSGVDTYLNLEEDISTDGLPSYRIEKVHTKAGRYRLGTITFAEYLENKVQTAETWRPLVKMVFVEAKEDTDFYLYGIIAIRKGYDNDLVAEIPDNSSGETYLLGTPIEADGIQLPFSHWVLNIKDERKYPPTADRERLSDNAINAIEDKVKSSLKEKLQFLNLKSVQEYVESQYKPIYRVLEGMGLGEYLSEYTVDLAKFVEISVKTPEYPNRTKIRDLLAQSQNLFYLDSLNENKIALIRSKVPDAIVFKLSSGKKEREQSSSSTVVVDPFQLFRRFDVKFGEEFIRENNLKMKRRERIVPEDLPVHEAGAGWYSWGRFRTVKRHTTRTAREDIGRDTIRVPEGSMRTYLRLLSMVKTRYKIVKDDRELESSGTGTTLKSFVDSIGRKMVQTSDGKMRVTDTITHSSKKKMKLVLYSDPSITRHMHSEEHLSIAGDDDLLFELMAFCEFHRIEYTADVDGSEALAHVEGHNYRRSEFIADPSYPKIGDSEILYSVAHAAKAVKDGKMLNIFLNAVRYSKEAAEVREMREYLISKEVGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG8</accession>
    <name>K0IKG8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58922">
        <property type="protein sequence ID" value="AFU58922"/>
        <property type="gene ID" value="Ngar_c19900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19900"/>
    <dbReference type="HOGENOM" id="CLU_1127119_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1988-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="28593" checksum="E9CBEBA6836D6030" modified="2012-11-28" version="1">MIILQNGEQLIRKDGAELFSDEKKFGKGTLYLTNIRMMFETENGMVQRLIVLHSIQSVVPVKKHEFTVSYMNDDSTGIFTDRYKIMDGEKCEDWIEDFRNICNTSMLSGANSVYSKSTTEGRENRIESLQDDRQNVNDVVVDVNSKTLSWKKIEGWRKFPDEHIWQGTKRLDSMTNEEWHAFKQESFALDDRLFKLKHEYLNAKKRGDKQRCAEIGEEMQIINLELTGRKVIPFKSITREQFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI5</accession>
    <name>K0IKI5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh3</name>
        <name evidence="4" type="ordered locus">Ngar_c20250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20250"/>
    <dbReference type="EnsemblBacteria" id="AFU58957">
        <property type="protein sequence ID" value="AFU58957"/>
        <property type="gene ID" value="Ngar_c20250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20250"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="OMA" id="YTACKRS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="6"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="353" mass="38294" checksum="0269D5326F2B4844" modified="2012-11-28" version="1">MQMLSARIHQYQRPLVVERVPKPSNVHGEAVLVRVGAAGLCHSDLHLINGEWKDAIPLALPKIPGHENAGWVEEIGNTVPEGLFSKGELVAIFGGWGCGICTFCKRGDEQLCVAPQWPGLSQRDGGYSEYILVPSYRFLVKVPKKGRLTPEELAPLTDAGLTPYRAVKKVTHMLGPGTNIAIVGMGGLGAYGIQYARLLAPHSTVIAVDRKDKKLSLAENFGADRTVNSATTRNIRDEVLELTDGRGIDVVVDTVGAENTIADSVRMLAKGGALVVVGLFGSQIKIPLLPAIVNEYQVIASLWGNYNELKEVIELASQRKIKHAYQSFSLKEINQAIDQLRQGQIIGRAVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK7</accession>
    <name>K0IKK7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S17e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps17e</name>
        <name evidence="5" type="ordered locus">Ngar_c20760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20760"/>
    <dbReference type="EnsemblBacteria" id="AFU59007">
        <property type="protein sequence ID" value="AFU59007"/>
        <property type="gene ID" value="Ngar_c20760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20760"/>
    <dbReference type="HOGENOM" id="CLU_137726_1_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9380" checksum="21C5A72BCDD925E8" modified="2012-11-28" version="1">MNRIKRISTELLQKYPDRFGLEFDANKKALNDLAVVRSKVLRNELAGYITAHLRKQEAQAKASMAAAAGETEEEQESEEEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS2</accession>
    <name>K0IKS2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59943">
        <property type="protein sequence ID" value="AFU59943"/>
        <property type="gene ID" value="Ngar_c30270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30270"/>
    <dbReference type="HOGENOM" id="CLU_2140281_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3027-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="11520" checksum="D3F6A3B244C8B37B" modified="2012-11-28" version="1">MVVSAAVPAFALNQSTIINSNDNVNQGNVQLSKQWAKATTTTNQGVNRPQASTNQLAVGSVQVGVTSQDNSQTSTSGNFIGQSSTQSANNIHVSSRTTTTSQTAVCAVFAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKY8</accession>
    <name>K0IKY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acsA1</name>
        <name evidence="7" type="ordered locus">Ngar_c22900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22900"/>
    <dbReference type="EnsemblBacteria" id="AFU59217">
        <property type="protein sequence ID" value="AFU59217"/>
        <property type="gene ID" value="Ngar_c22900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2266"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="6">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="5">
        <location>
            <begin position="526"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="647" mass="72302" checksum="2AACFEF17F6079A9" modified="2012-11-28" version="1">MSSPSKLYEESGRIKVNVTPGRRLEKVSKEALAEPEKFWAEQARNLVWFKEWDRVLDWKPPFARWFVGGQLNASVNCLDRHVKTDTKNKTAIIWEGESGETRTLSYFQLYRQVNKFANVLKSLGVGKGDRVTIYMPMVPELPIAMLACARIGAIHSVVFSGFSSQALVDRANDAQSKIIITADGGVRKGRLIELKKVVDESLPSIQSIDHVIVLKRAGNEVGMGPRDLWWHDLMEGAKTYCPPEPVESTHPLYILYTSGTTGKPKGVMHGTGGYLTHLYATAKWVFDFNKQDIFFCTADIGWVTGHSYIVYAPLMHGATEIMYEGAPDHPRPDRYWAIVEKHGATILYMTPTALRMYMKYGDVVPNSFDLSSLRLLGTVGEPINPEVWMWYFKTIGKEICPIVDTWWQTETGGIMLSMCTGIETIPMKPGSATFPVPGVDAAVVDENGKPVPPGTKGYIVVRRPWPGMLLTLWGDDEKYKQVYWSKFAGMYYPGDYAMIDQDGYLWLLGRADDVLKVAGHRLGTMELESAFVSHKAIAEAAVTSKPNNTKGESIIAFLVPKEGFTHSDDMRTEIVAHIRNTVGPIATPDEVYFVNKLPKTRSGKIMRRLLKSIACGDKIGDITTLEDGAAIDEVKQAYEDLKKVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL64</accession>
    <name>K0IL64_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59347">
        <property type="protein sequence ID" value="AFU59347"/>
        <property type="gene ID" value="Ngar_c24230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24230"/>
    <dbReference type="HOGENOM" id="CLU_2103585_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2421-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="13229" checksum="AD1FBFE4D99A0975" modified="2012-11-28" version="1">MQVLSTRFTNAHGLDLLDIMSGQQINIVVTFKNYQQVEQNYALIIQVEDSNGIVTHIDWVEGKLAYGQTTQHTRQWITPTEQGLYRIKIFIWDGIFIIAPTPLSERTVENIHVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL65</accession>
    <name>K0IL65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60173">
        <property type="protein sequence ID" value="AFU60173"/>
        <property type="gene ID" value="Ngar_c32580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32580"/>
    <dbReference type="HOGENOM" id="CLU_2821045_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3258-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="6983" checksum="A739CAC9E0AC5E90" modified="2012-11-28" version="1">MSATSSKSRIVLFLLVVIALVFFITSFVAAAFTNSVNNSIQEASSQASCIIVQTGEDKVFGECGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF8</accession>
    <name>K0ILF8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60388">
        <property type="protein sequence ID" value="AFU60388"/>
        <property type="gene ID" value="Ngar_c34740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34740"/>
    <dbReference type="HOGENOM" id="CLU_1418731_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3475-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="191" mass="21534" checksum="18D5213E78F25041" modified="2012-11-28" version="1">MPVFQLSALIDALEEQGFSCRVGSMELDVHPMKRPYFERWLSNRDGFLRMASGSVDFIGIEDVVRMGPFYNVYCLVENDFIVDTDDNAHKLLDAAPYFQLHNGKVTSMGWSGGVIANMLAKDTALSEEFACNIMKEEVKMITVKAANYCCIIETRAWEPVGLASAFATIDRIAHNIRRLVKTIHLGEYIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI1</accession>
    <name>K0ILI1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c01440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01440"/>
    <dbReference type="EnsemblBacteria" id="AFU57094">
        <property type="protein sequence ID" value="AFU57094"/>
        <property type="gene ID" value="Ngar_c01440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01440"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.144"/>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OMA" id="QIDCACA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-144-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="326"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="400" mass="42714" checksum="6127C58C42B592F9" modified="2012-11-28" version="1">MIIGLIGKANVGKSTFFNAATELAVPAANYPFTTIEPNVGVAYARVKCVCREFGVQDNPVHSMCIDGNRFIPIKLVDVAGLVPGAHAGKGLGNKFLDDARQADALIHVVDASGTTDSNGRSVPAGAGDPMFDITFVEEEFDLWLAALIGRDWGKNTREAEGLGQKLEQMLAKRLSGLAIGEPVIAAAIHASGLAMKKPVSWTEEDILAFCKILRAKAKPFVIAANKADLPSAEVNIEKMKSAGLEVVPCASEAEALLRKASKKGVLHYLPGDSSFDVKPNVALNIQQQKALDIVRTLMQKYGSTGVQEAINIACFKLLRMVAVYPVEDEFKLADKKGNVLPDVRLLPEGSTAKDLAGTVHADLAKGFLYAIDARTKQRIGADHKLKSGDVIKIVSATSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI3</accession>
    <name>K0ILI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59497">
        <property type="protein sequence ID" value="AFU59497"/>
        <property type="gene ID" value="Ngar_c25760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25760"/>
    <dbReference type="HOGENOM" id="CLU_3338595_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2575-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4360" checksum="CD2DF27E553E727E" modified="2012-11-28" version="1">MLVQNGLLEYEKDIQTFKTTNKCHKFVKVYNQIGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM9</accession>
    <name>K0ILM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59572">
        <property type="protein sequence ID" value="AFU59572"/>
        <property type="gene ID" value="Ngar_c26500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26500"/>
    <dbReference type="HOGENOM" id="CLU_2550386_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2650-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8478" checksum="8A7A75596E3758E5" modified="2012-11-28" version="1">MISPGIQMLEVAIGIKDSLMAAGFTSIDSLLRSNPTDIAAVLGIEIYVAKLIIDAAKRASGRESKVDAAESNNNATAVAAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW5</accession>
    <name>K0ILW5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c28170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28170"/>
    <dbReference type="EnsemblBacteria" id="AFU59737">
        <property type="protein sequence ID" value="AFU59737"/>
        <property type="gene ID" value="Ngar_c28170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28170"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2782"/>
    <dbReference type="HOGENOM" id="CLU_945332_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2817-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="294" mass="31553" checksum="5B3E820F035BE59C" modified="2012-11-28" version="1">MFMTYGAVPDRLFNDFPASAPTILTSMFMHGGIAHIIGNMVFLFVFGDNIEDKYGRIKYILIYIGWGVAAALAHSAYAVSTGEGEIPAVGASGAISGILGAYMVMFPRARIFTVIAAFFLYTVRIPVLIYIPLWFAMQVIFAVIGQLGPAGTAGVAYLAHIGGFVAGVAVGLAWKALPDSIKYKEGIAAAAGGAKPAFRGPMFRKTRPRIEDVATAAPEVIEGPDYYEVIAEIRGVSDASDITASYDADSRQVRIVAHGTRKYEMSAKLPATAVNPVVKYIQYLNGIARIRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW7</accession>
    <name>K0ILW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28220"/>
    <dbReference type="EnsemblBacteria" id="AFU59742">
        <property type="protein sequence ID" value="AFU59742"/>
        <property type="gene ID" value="Ngar_c28220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28220"/>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="OMA" id="ELMITAF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2822-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="270" mass="31112" checksum="0B5275C6FEE54D58" modified="2012-11-28" version="1">MSDQQPNEGVGSLFFELAGDLRLSMLTKLSQKNYRLSQLASELDATMQEAHRNMTRLVDSGLVAKDKEGELVLTAYGRTVVTMISGYDFLYRNRDFFLDHSLGDLPPKFIQRMGALQNCEIVHGVMAILQRWKNLYSESEKYIREIMAQVPLDLIETVSSRVEAGVKFHYIFASNSVVPKGRTQLLQKVGWRNFISKGLVERRMLPEVKVMMIFNEKQGCVLFPNMKGEPDLNVMFYGEDKEFLEWCADLFNYQWEKAGPFDESKLKHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX5</accession>
    <name>K0ILX5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">pdxT</name>
        <name evidence="7" type="ordered locus">Ngar_c28470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28470"/>
    <dbReference type="EnsemblBacteria" id="AFU59767">
        <property type="protein sequence ID" value="AFU59767"/>
        <property type="gene ID" value="Ngar_c28470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2817"/>
    <dbReference type="HOGENOM" id="CLU_069674_2_0_2"/>
    <dbReference type="OMA" id="VFIRAPI"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="216" mass="23585" checksum="3A35838027F717AC" modified="2012-11-28" version="1">MSSSKKKPVVTIGVLGFQGDIEENIAATKQALQEMQVEGNVELVRYPEEVEKVDGLILPGGESTVQSTLAAIQRSLPVIKKRISEGMPVMGTCAGMIMLSRRAFDRVVGDTKQKLIGNLDIVIERNAFGRQNDSFEADLSIGMLGKEAFKGVFIRAPAVSEVGKDVEVLAKLNNKVVAVRQKNIIGTAFHPELSGDSRMHRHLVKMAIDFKHKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM13</accession>
    <name>K0IM13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59877">
        <property type="protein sequence ID" value="AFU59877"/>
        <property type="gene ID" value="Ngar_c29590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29590"/>
    <dbReference type="HOGENOM" id="CLU_3178705_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2959-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="4925" checksum="1D9B5D84FF4593DE" modified="2012-11-28" version="1">MLLTREYSRKAGSKAGDKKQAGIYAAGSQAVVQLQPHLTNAECMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM64</accession>
    <name>K0IM64_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c31210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60037">
        <property type="protein sequence ID" value="AFU60037"/>
        <property type="gene ID" value="Ngar_c31210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31210"/>
    <dbReference type="HOGENOM" id="CLU_1485939_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3121-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="181" mass="19430" checksum="C5D05F7825B8006D" modified="2012-11-28" version="1">MFRFELLDTGTGQPPVPEGEAFVPTPPLSQTTGRGTYIVKLDWSPEAIEPGQQVTFEVTFEDNTGFPLNRVNYDLIVQNANGSTIEEFTVQNTDATGTGTHQIIFENAGSISVAVVINTVEGRQPGGGQFIERADFNVVAVPEFPMGGITTTTIISATAIGLVVIVLRLKANRNAQGYPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM95</accession>
    <name>K0IM95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32060"/>
    <dbReference type="EnsemblBacteria" id="AFU60122">
        <property type="protein sequence ID" value="AFU60122"/>
        <property type="gene ID" value="Ngar_c32060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32060"/>
    <dbReference type="HOGENOM" id="CLU_153620_0_0_2"/>
    <dbReference type="OMA" id="DRPMNAN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3206-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12725" checksum="FDC843D92353EEEE" modified="2012-11-28" version="1">MPDPNAKRLLWYLFAGSRGGENRIRIIDLLKERPHNMNQLAEEMGIDYKAVQHHIGVLEKNNMVTKTGEKYGVLYFISNYLEVNIEAFNEVRAAIEKKRSSSSRDLEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN8</accession>
    <name>K0IMN8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58059">
        <property type="protein sequence ID" value="AFU58059"/>
        <property type="gene ID" value="Ngar_c11170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11170"/>
    <dbReference type="HOGENOM" id="CLU_2550378_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1115-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9011" checksum="542A4C5442A44CF3" modified="2012-11-28" version="1">MAMFQPVDTVKIHIDQDVKKPDGTQVTIDDIRPDYLFGNGVTCCGFTLKDGTDVAAVFFVVDQAYDTQVRAILEDIKTAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMS3</accession>
    <name>K0IMS3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58144">
        <property type="protein sequence ID" value="AFU58144"/>
        <property type="gene ID" value="Ngar_c12040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1149"/>
    <dbReference type="HOGENOM" id="CLU_1559540_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1202-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="19933" checksum="BFA3771969B908E6" modified="2012-11-28" version="1">MRNKLDHPADLDPLLERIGDKRHVLLGEASHGTSEFYTWRAEITKRLITEKGFSFVAVEGDWPDCYKVNRYIKGFQNSGSNASDVLYSSFKRWPTWMWANMEMVGLVEWFKSYNNNSCQKGEEEKVGFYGLDVYSLWESMEAVVQYLQKIIPMPYKRRLEPTGALSLLEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN25</accession>
    <name>K0IN25_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58634">
        <property type="protein sequence ID" value="AFU58634"/>
        <property type="gene ID" value="Ngar_c17010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17010"/>
    <dbReference type="HOGENOM" id="CLU_2629854_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1699-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8737" checksum="6BC2747527EF96E4" modified="2012-11-28" version="1">MSPLKSVLLVNRTLFLDNDPRCNYLLPLTNGITVNEFASEIMRACANYDKSVTWEGAKFLARELLESDTKGVEMPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN60</accession>
    <name>K0IN60_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Elongation factor 1-beta</fullName>
            <shortName evidence="6">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ef1b</name>
        <name evidence="8" type="ordered locus">Ngar_c18770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18770"/>
    <dbReference type="EnsemblBacteria" id="AFU58809">
        <property type="protein sequence ID" value="AFU58809"/>
        <property type="gene ID" value="Ngar_c18770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18770"/>
    <dbReference type="HOGENOM" id="CLU_165896_1_0_2"/>
    <dbReference type="OMA" id="YELEYFS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="PTHR39647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006521">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="SSF54984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF1_GNE" evidence="7">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10176" checksum="76A199193D0B93BD" modified="2012-11-28" version="1">MARLVARIRIMPADAESNLDSVVNSIKSSLPEGMEMKGHAMEPIAFGLKAIVGDFLLEDAEGQMDKLEESIKNVEGVGEIEVMNISRQSVKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB3</accession>
    <name>K0INB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59074">
        <property type="protein sequence ID" value="AFU59074"/>
        <property type="gene ID" value="Ngar_c21440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21440"/>
    <dbReference type="HOGENOM" id="CLU_2839486_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2142-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7315" checksum="D6A800BC8243BB38" modified="2012-11-28" version="1">MANGIIYDRLDFDDDLNTCLIFFNTKNVSAIDIPPLEKAAQEVNAELSAVIDSSKDQLCFFVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB5</accession>
    <name>K0INB5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59084">
        <property type="protein sequence ID" value="AFU59084"/>
        <property type="gene ID" value="Ngar_c21540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21540"/>
    <dbReference type="HOGENOM" id="CLU_113981_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2152-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="209" mass="23538" checksum="59F26061B442878C" modified="2012-11-28" version="1">MSIIPNKRDVIVDNDAKSTFLVNDKNFYANGVLDNNNGATLSSSENIIATIDEALKPYGEESRKLILHCIRHKYGLDPVLLAKYKEEFGHYLCEIIGNQAAEVILSKVRQDNVSNLKIVESKSSLIIADSLKKKEADRRKRISDKVYFVICDSCFWCASYLKPIPASSSTMQCASCGYNIESAMPIALDESMRLGECASEKTMIWYFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC8</accession>
    <name>K0INC8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mercuric reductase, MerA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59149">
        <property type="protein sequence ID" value="AFU59149"/>
        <property type="gene ID" value="Ngar_c22190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22190"/>
    <dbReference type="HOGENOM" id="CLU_1912408_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2217-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="132" mass="14901" checksum="7507913DFABD022D" modified="2012-11-28" version="1">MKHYRSKPSSMIVIGGRALGLEFAQMYARFGTKVTLLQRSDRIIPDHEPEISDALRHLISTDDRIDIVTGVQVDQVYQKDGSKYVKASVDTGKKVLVFEAEQLLMATGRRPNTAVAFGKCWHQNKKRRGCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI6</accession>
    <name>K0INI6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isocitrate/isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
            <ecNumber evidence="2">1.1.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">icd</name>
        <name evidence="2" type="ordered locus">Ngar_c25160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EC" id="1.1.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25160"/>
    <dbReference type="EnsemblBacteria" id="AFU59439">
        <property type="protein sequence ID" value="AFU59439"/>
        <property type="gene ID" value="Ngar_c25160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25160"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2494"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_2"/>
    <dbReference type="OMA" id="KLFRQPS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="342" mass="37503" checksum="AEF1A53C54FEAEDB" modified="2012-11-28" version="1">MASTKTAAVIRGDGTGPELVNAMIKVLKACNSKVELVPCDAGSEWWEKNGGTSYISPEVWKLLEESDACFKGPTTTVPVPNAPRSVAVSIRQKFELYANIRPIKTYKNAEKQLDFVCVREATEGLYAGIEFKTSDDSAVAIRKTTRKGCDRVAKAGFEVAKKRGFGKVYAITKRNILKETDGIFWAAVENAQKQFKNIQVEEYYIDNMTQQLVKNPERFNQSVLLSTNLFMDIVSECASGHVGSIGNVYSGNYGDKYAMFEPAHGSAPKYAGQNKVNPVATVLSGAWMVEYLGEKHISDAIFKATEDVINEGKYVTYDLGGSATLSQMADQIAARAGKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ4</accession>
    <name>K0INJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phage shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25570"/>
    <dbReference type="EnsemblBacteria" id="AFU59479">
        <property type="protein sequence ID" value="AFU59479"/>
        <property type="gene ID" value="Ngar_c25570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2534"/>
    <dbReference type="HOGENOM" id="CLU_056466_1_0_2"/>
    <dbReference type="OMA" id="MIFRAKA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2556-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="94"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="28310" checksum="4BB605B02C27C2E3" modified="2012-11-28" version="1">MGLMNRFSAVIKQKVNTLLDKFEDPREALDYSYIRQLEMLNKVRRGLAEIITSRKRLEMQKSKLWDNIRLLDEQASRALDAGREDLARLALERKNTNLLQIQDLDKQIAELQEEARKMEEAEKRMAVKVEEFKSKKEVIKARYSAAEAQVKIKESVTGISEEMADVGMAMNRAEEKTESMRAKAQALDEMINSGVLTDYTSNKDEIERELEKITVQNSVEEELAKLKSEKERKKKQRVEQEAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK6</accession>
    <name>K0INK6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59539">
        <property type="protein sequence ID" value="AFU59539"/>
        <property type="gene ID" value="Ngar_c26170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26170"/>
    <dbReference type="HOGENOM" id="CLU_2177962_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2617-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12014" checksum="FF3B59B324665C3D" modified="2012-11-28" version="1">MTPEQTAEAIKNIARRIREESTKMRETVKIIRQSGAIEELTEAVREATLAARDSAKEINEVANDLKKRGVIRETLSAAEETGATARDTAQTMRETVSREASKEKTTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL9</accession>
    <name>K0INL9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gabD</name>
        <name evidence="3" type="ordered locus">Ngar_c26830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26830"/>
    <dbReference type="EnsemblBacteria" id="AFU59604">
        <property type="protein sequence ID" value="AFU59604"/>
        <property type="gene ID" value="Ngar_c26830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2658"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="463" mass="51257" checksum="4065A05E8896BBA0" modified="2012-11-28" version="1">MPKIETINPSTGKVIAAYENEGPEQVSRRVKAARDAFAKWKKMDLAERSECMRRLGGVMRKNREEYARLVTEEMGKPIRQALAEIEKCAWVCDYYAERAEVFLRDEIIPTEFRKSFVSFEPLGVVAAIMPWNFPFWQVMRFAVPALTAGNVGVLKHSSICLGSALKLEQAFRDAGFPENVFQSVIGDYRAGEALVQADVDAVSITGSVNTGRRVAELASQDLKKFVLELGGSDPFVVLEDADLNQTAYMATQSRLLNTGQSCIAAKRFIVVQEIADKFTKLFVENTQAEVVGDPLDSKTTVGPLVRDNQRQALAKQVEDAKGKGGKVLTGGQPLKREGFFYEPTIISNVNHDMDVVREEVFGPAAPIIVVKNEEEAIREANNSEFGLGASIWTNNIERGMRLARQIESGIVSVNEMVKSDPRLPFGGIKKSGIGRELSEFGIREFVNIKSVVVKDITSKLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN1</accession>
    <name>K0INN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59664">
        <property type="protein sequence ID" value="AFU59664"/>
        <property type="gene ID" value="Ngar_c27430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27430"/>
    <dbReference type="HOGENOM" id="CLU_1431693_0_0_2"/>
    <dbReference type="OMA" id="ISIPCHC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2743-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20632" checksum="885FF12650582D49" modified="2012-11-28" version="1">MVNKKYATIGGAAVAAVIIAVAAMSSSFQTSNSLSLTTVSGNEKAEGLKVGNSAPSFSLTDPENGSITKQTFVGKPVLIFFTTTWCTPCQIGAQNIAKLDDETGGNAFNVLIVFVDPRETDEQYLQWKQNYGRDDWYVAESEQMPQEYHVRYLDTKYVFDSNGIVKWVDVNPLEYSKVKQVLEPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP8</accession>
    <name>K0INP8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl24e1</name>
        <name evidence="3" type="synonym">rpl24e</name>
        <name evidence="5" type="ordered locus">Ngar_c28290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28290"/>
    <dbReference type="EnsemblBacteria" id="AFU59749">
        <property type="protein sequence ID" value="AFU59749"/>
        <property type="gene ID" value="Ngar_c28290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28290"/>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OMA" id="FCGRHIT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="PTHR10792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8204" checksum="272ABDD14EBA4CF3" modified="2012-11-28" version="1">MSKTTATSLRNCFFCGRHITTGHGVMLVRNDGQVQWTCSSKCKKNLRVLQRDARKLKWTSRYVKGGLRMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR2</accession>
    <name>K0INR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59819">
        <property type="protein sequence ID" value="AFU59819"/>
        <property type="gene ID" value="Ngar_c29000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29000"/>
    <dbReference type="HOGENOM" id="CLU_1567210_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2900-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="18681" checksum="039064D974456F7F" modified="2012-11-28" version="1">MYFFISAERQEEIRDSLIVDAIANARHRAEVTAEAVGMSIYRIQSINLNYVYFPVFSRGIAAAEPVATPILPGEQQVSSMTVNIVFYMSGAAVSSGGSEDDGGGSFGLTEPAMEFLLSKLPELGIQIKDKLNVHMDQVVHISENEYHVEFSVRDVNGQMHDAHIEVVDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP18</accession>
    <name>K0IP18_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrF</name>
        <name evidence="6" type="ordered locus">Ngar_c34340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34340"/>
    <dbReference type="EnsemblBacteria" id="AFU60349">
        <property type="protein sequence ID" value="AFU60349"/>
        <property type="gene ID" value="Ngar_c34340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34340"/>
    <dbReference type="HOGENOM" id="CLU_067069_2_0_2"/>
    <dbReference type="OMA" id="EMSHPGA"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="248" mass="26321" checksum="DC5758D6FA142EB9" modified="2012-11-28" version="1">MSNSREPFRERIARAADAKKSPIVLALDLPTSKRNLPAFAAKTIRAVGQHICAVKMNFHLILPLSASEISRINKLVHSYGLQSIADIKLNDIENTNEVAIDHLTRMGFDAVIANPFIGKGGLAALVQKAHKAGAGVIALVYMSHPGAKEGFGLEVGGRGLYSEFLERATGAGADGIVVGATQLDILRQVAKQQLPVYSPGIGAQGGDAEQAIRSGADYLIIGRSIVEAAQPAKVAKEIQSRILLSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7R2</accession>
    <name>K0I7R2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03180</name>
        <name evidence="2" type="ordered locus">Ngar_c03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57266">
        <property type="protein sequence ID" value="AFU57266"/>
        <property type="gene ID" value="Ngar_c03180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57296">
        <property type="protein sequence ID" value="AFU57296"/>
        <property type="gene ID" value="Ngar_c03480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03180"/>
    <dbReference type="KEGG" id="nga:Ngar_c03480"/>
    <dbReference type="HOGENOM" id="CLU_2968564_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-318-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6388" checksum="7399AFF741FF1FBE" modified="2012-11-28" version="1">MSQEIPIEIGVICKCGQAFKHVLNFVNHAKKCDKFAKTDSGLKRIAEQLLSLKEGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I826</accession>
    <name>K0I826_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57426">
        <property type="protein sequence ID" value="AFU57426"/>
        <property type="gene ID" value="Ngar_c04820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04820"/>
    <dbReference type="HOGENOM" id="CLU_2534789_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-480-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9111" checksum="4682AB50E4CAE723" modified="2012-11-28" version="1">MMIPAMEEASRVAEVVDSLHDLIESKQVGADIAIVSLVSAAGEVALSLIVAQPELKEAYLKVFNSAVEQVRRQLRHEIKARKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0I879</accession>
    <name>K0I879_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp20</name>
        <name evidence="4" type="ordered locus">Ngar_c05330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05330"/>
    <dbReference type="EnsemblBacteria" id="AFU57476">
        <property type="protein sequence ID" value="AFU57476"/>
        <property type="gene ID" value="Ngar_c05330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05330"/>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="180" mass="20609" checksum="EB6D8167E482D32B" modified="2012-11-28" version="1">MWRDFDLGFGTTRRLFEDIDREFRDAEEMLNRMFRTVREMNPSDIAGTFPYYYGYQITIGPDGKPHVREFGNVRPSARGLVEQSGVREPLVDTKLEEKDNTLTITAEMPGVTKQDIKVKVSPEYVSIHAEKGDKKYHTDIPVDVELDDKSAKATYSNGILELKIKLKAPPKPKETEVQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I894</accession>
    <name>K0I894_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57491">
        <property type="protein sequence ID" value="AFU57491"/>
        <property type="gene ID" value="Ngar_c05480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05480"/>
    <dbReference type="HOGENOM" id="CLU_854227_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-546-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="325" mass="37374" checksum="C90D0B4D6CA47166" modified="2012-11-28" version="1">MPWITRGGRPQFVGDWGSLSDGERWAAIHNRNAAREESESWGEEKDEVTTYESSEAIKRLRLENYGYFALRRHSSWNYSIDIESKDMQIVYALKFSKDQVFAMIDEIEQEIVGPKQELHPKKIKIKLEKDREGYLLNVELDSVSALLPFQNMNDVVHFQSELKSITSWTRDNSSLVPQKVLDYLNQNSDAGIADEIVSFVKNEYPKEKLAFAGNYDFPSMIRGFWSRKGLDRGDFHRYPDEIRSRIDSAEALASKELTKVAFVHKLELFESLISEGVKYAGEIGRPTLRLKDLDALLAKKEVHLNTKLKQLLFAVVNNRLLPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8V4</accession>
    <name>K0I8V4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c07280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57671">
        <property type="protein sequence ID" value="AFU57671"/>
        <property type="gene ID" value="Ngar_c07280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07280"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="DTCRQVY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-726-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="164"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="274"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="375" mass="44220" checksum="76F9369C0411CCF5" modified="2012-11-28" version="1">MLNYKFRLYPTKEQELVLEQTLDGCRWLYNYLLDKNNMSEYDMNYALTELKEQHLWLRNYHSKMLQMVAKQVAAARKVVAKGGKLSYRKKEDFNSFTYNQSGFRLESDKQLSLSKIGSIRIVLHRKPVNVKQVTICRSKAGRWYALVACQLPRRSFTVIRYRNPVGIDVGIAKFCHDSDDHVEDNPQFLTRMLRPLRRAHRRVSRRQIGSSNHEKAKHMLARLYERISNNRRDFLHKLSTYYSSRYDLIFLERLRVSNLTRNHRLARKILDASWSTFKQMLQYKANRVIEVEPAYTSVDCSRCGHPVPKSLAVRTHVCTKCRAVLDRDYNASLNIRKRGLESLLLLLPVERREVTPAEIVQRSLKQEEAHEFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I913</accession>
    <name>K0I913_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57771">
        <property type="protein sequence ID" value="AFU57771"/>
        <property type="gene ID" value="Ngar_c08290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08290"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-827-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11117" checksum="86E10310D326B7D9" modified="2012-11-28" version="1">MIKYRSRTDIASQMLEAANGGTTKTKIMYKAFLSYSQLREYLSMLTDNGLLEYDKSTETFKTTEKGTRFLRICNEMGKYASPETATTETKGKMQSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0I917</accession>
    <name>K0I917_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57781">
        <property type="protein sequence ID" value="AFU57781"/>
        <property type="gene ID" value="Ngar_c08390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08390"/>
    <dbReference type="HOGENOM" id="CLU_204995_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-837-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7549" checksum="AB3527D11E396289" modified="2012-11-28" version="1">MRMPGMNGFELARKVKAANPEIKIFLMSAFELSISEFEKVLPSIKVNGMLEKPVSMHMLVSLIVKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0I964</accession>
    <name>K0I964_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PilT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09240"/>
    <dbReference type="EnsemblBacteria" id="AFU57866">
        <property type="protein sequence ID" value="AFU57866"/>
        <property type="gene ID" value="Ngar_c09240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09240"/>
    <dbReference type="HOGENOM" id="CLU_135601_1_1_2"/>
    <dbReference type="OMA" id="CEGYINI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-922-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="14664" checksum="81AE12079A3D275D" modified="2012-11-28" version="1">MPKKIVFDSQPLLSFFLQEEGAAKVENLINQIERGSCEGYINIVNLIELRYILARAGKDLAEESLISSGMKIIPLVVGEDIWQIAAELKASHPISLADACAAATARVLDCQLVVSADPEFKALESKNLIKIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9V9</accession>
    <name>K0I9V9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blue (Type1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11760"/>
    <dbReference type="EnsemblBacteria" id="AFU58116">
        <property type="protein sequence ID" value="AFU58116"/>
        <property type="gene ID" value="Ngar_c11760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1116"/>
    <dbReference type="HOGENOM" id="CLU_626452_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1174-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="356"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="437" mass="44432" checksum="D083CD3CE179C750" modified="2012-11-28" version="1">MLGSLTFGVTGFAGAQVNVTSNATTVDNTTSTASTGNATGTNQTGGGEGTTTAAADDTFRARGTINDFISSAMSDNATAANATSDGYILGGRWRVDVIGGEVRQVQANISMAKPDGSDFHMHLIDNFTAGGGANETTTANATGANMTGGGGDSGMDNATAGNMTEGNETTTTLPQVMTGGNNTTGDNATTRVGNATTPGNETTTAQVTLSEDGTFEISGTATIYTNNDPQWENVPITIKNTGRVLTINVDHEMTDNHFMGLPIYGFVTGLIGGDNRSVLPPLEGVEPSPTTPAPTIPNATTPTGNATAPTGNETSGNQTTEGPAPSPTTNETTGGGGGQTIAVSITPGSSSKTTDSFDPNPVEASVGDTVTWTNDDSTPHTVTSGSNGQPDGRFDSSPNLNPLMNPGQTFSHTFEEAGEYPYYCALHPNMVGTVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAF1</accession>
    <name>K0IAF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58291">
        <property type="protein sequence ID" value="AFU58291"/>
        <property type="gene ID" value="Ngar_c13530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13530"/>
    <dbReference type="HOGENOM" id="CLU_2010158_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1351-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="14261" checksum="1FB30D3A530AA1B3" modified="2012-11-28" version="1">MATPADSDPSQAWQVVHKPTGHKYLMYTVPSREIAQTINWKRKRLSTLLYDYQHAKSPEERAAKRSEFDSENKHLEWIMVEFLQDCLGLTMDQIKAIGTQECVEIFVEVIDYCEKNGPSERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAJ7</accession>
    <name>K0IAJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58341">
        <property type="protein sequence ID" value="AFU58341"/>
        <property type="gene ID" value="Ngar_c14050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14050"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1403-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="15056" checksum="50B528DFFAED2CFF" modified="2012-11-28" version="1">MIVDDDEIYHLPEVVLRLSKSIRHCEVVDRSGNIVASKARNDLQPFTDENGHRQALEAAMRYFRTPSWARNIGKMYYNASRYEKVIGAVIPIADRYLLLVSFDHNMNDFDKIIMKKIMLLVKRISESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBU6</accession>
    <name>K0IBU6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58751">
        <property type="protein sequence ID" value="AFU58751"/>
        <property type="gene ID" value="Ngar_c18180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18180"/>
    <dbReference type="HOGENOM" id="CLU_2406453_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1816-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="9705" checksum="23A380BF9892904B" modified="2012-11-28" version="1">MSLEVLAKSGAIVSSAGVALLVAFVVVLLAFPVIKECEDSKERCSYTSTAPEQLAAIVQPGFLAVTLLIIAAGVFMVRFSRWRSDKKTSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBY6</accession>
    <name>K0IBY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58826">
        <property type="protein sequence ID" value="AFU58826"/>
        <property type="gene ID" value="Ngar_c18940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18940"/>
    <dbReference type="HOGENOM" id="CLU_2875207_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1892-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7520" checksum="55CCD375D4E3990B" modified="2012-11-28" version="1">MTNKIPCKQHGTEKMMMDRLYKRGSKQNDQQFEEIGGYCEKCGYIEYDSALLNHKREKRLQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC00</accession>
    <name>K0IC00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58851">
        <property type="protein sequence ID" value="AFU58851"/>
        <property type="gene ID" value="Ngar_c19190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19190"/>
    <dbReference type="HOGENOM" id="CLU_3021091_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1917-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6710" checksum="539DE0815230F85C" modified="2012-11-28" version="1">MMGQSHITIDATKCLLIAQEWLPVYDYFERQFEIMKNIRGLEQDVDFPYILRYCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC27</accession>
    <name>K0IC27_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NIFsuperfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01500"/>
    <dbReference type="EnsemblBacteria" id="AFU57100">
        <property type="protein sequence ID" value="AFU57100"/>
        <property type="gene ID" value="Ngar_c01500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01500"/>
    <dbReference type="HOGENOM" id="CLU_075763_0_0_2"/>
    <dbReference type="OMA" id="PLNHNRA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-150-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="29511" checksum="E3694F1C58C2BFF4" modified="2012-11-28" version="1">MAVDTEKIMQVGLDLAGWKKMPADSAVHVKGRNINKVLIAIDVGAAELMLARQLGCDAVIAHHPIGVASVNFYKVFDRHVDFMMEHGVPTKTAKEAVAKLKERVETRNHADIYSEVVGAAKALGMPLVNIHQPCDEYMRQVILKAIKSGRTEYVSDIVRSIGKIPEFSNAATKVQVRLGSEKNRAGHWALVVAAGTNGGYHIAKAYMQHGVSTVIYLHVDYGDLMKMREDKLDGNLVVMGHLAGDSIGLNGLADQLEGLGVETVRVGILPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC95</accession>
    <name>K0IC95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58981">
        <property type="protein sequence ID" value="AFU58981"/>
        <property type="gene ID" value="Ngar_c20490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20490"/>
    <dbReference type="HOGENOM" id="CLU_3075479_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2047-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6027" checksum="58EA2B1F927C7380" modified="2012-11-28" version="1">MTRMRMSHNYHEVKAFNPETFCTKCGTATPRVCEWCGACYTCHKGAPEEKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICB0</accession>
    <name>K0ICB0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb1</name>
        <name evidence="6" type="ordered locus">Ngar_c02220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02220"/>
    <dbReference type="EnsemblBacteria" id="AFU57170">
        <property type="protein sequence ID" value="AFU57170"/>
        <property type="gene ID" value="Ngar_c02220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.220"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="REVACVI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="201"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="310" mass="34730" checksum="CCB3639CC3856EEB" modified="2012-11-28" version="1">MVVTDPDTGELIRKDTGEVISDNALSQEKEWRAFGSEGDADRARTGAPVSLAFHDMGLSTVIGKESTDASGNQIDSATQMRMGRLRMWHSISHSHSPKERSLQQAFTMLSKIKDRLGLPDYVIEKAAYVYRKAQERGLIRGDSIGSVLAASIYTAVRQSGVLRTLDEISASIDVKPKQAGRSYRRIVTELDIKVPMIDHARYIIRIANRLELDERTKRKALELIEQARKKDLLAGRDPIGMAASILYLVNLEEKSYRTQADIAKAAGVTEVTVRNRSKELRNRLDMDSNSRSTLRGQKFPLLNESNTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICE2</accession>
    <name>K0ICE2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02820"/>
    <dbReference type="EnsemblBacteria" id="AFU57230">
        <property type="protein sequence ID" value="AFU57230"/>
        <property type="gene ID" value="Ngar_c02820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02820"/>
    <dbReference type="HOGENOM" id="CLU_109676_2_0_2"/>
    <dbReference type="OMA" id="TVSWHVS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-282-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="20356" checksum="210FFE8B50E5222E" modified="2012-11-28" version="1">MIEEQAVEEVVEEGTRTMLLKHIEENPGIRYRELLRMTGLANGVLTYHLAALEKADVVKVDRQSRMTRYYPVSVSEDESTILKFVRHEPIRQIVLFILNHDLCTFNEIVDHTKKAPSTVSAHLKRLKEAGIISVRYGEYQLYRLADKELVAEVLSKYRASFTDKVVDNYAEMVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICH7</accession>
    <name>K0ICH7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03120</name>
        <name evidence="2" type="ordered locus">Ngar_c03420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57260">
        <property type="protein sequence ID" value="AFU57260"/>
        <property type="gene ID" value="Ngar_c03120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57290">
        <property type="protein sequence ID" value="AFU57290"/>
        <property type="gene ID" value="Ngar_c03420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03120"/>
    <dbReference type="KEGG" id="nga:Ngar_c03420"/>
    <dbReference type="HOGENOM" id="CLU_153621_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-312-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="16319" checksum="2E690EB3F637BC5F" modified="2012-11-28" version="1">MAKGWTVLTVRDQVKSRLEEIYEKDTKRPKNQKFTAYLDNLLTQYIDYHEKLQQYGPFIEYKDKRDNYVELYDHRKRQYVNVYINDQEKQLFCEFDNSADCCHVGFCFAIKEVYEILIDHGFRPPKIRASKGSATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICJ4</accession>
    <name>K0ICJ4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltA</name>
        <name evidence="7" type="ordered locus">Ngar_c03720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03720"/>
    <dbReference type="EnsemblBacteria" id="AFU57320">
        <property type="protein sequence ID" value="AFU57320"/>
        <property type="gene ID" value="Ngar_c03720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.359"/>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_2"/>
    <dbReference type="OMA" id="NEAVMHM"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="394" mass="44009" checksum="247EA2CA7627CE21" modified="2012-11-28" version="1">MDARNIGLRNIEVADTKICSIDGENGKLIYRGYDILDLVKHSTFEETAYLLLFGELPTASQLKDFSRRLTEARGIPEPLIKNLKNRPKRAQPMDVLQSCVSELADYDLNIEDSSKEAHVRRAITLIAKIPAIVAAWNRVRNGQHVVDPLEEGSHAANFLYMLRGVEPSAEEVKVMDICLILHAEHSFNASTFAAREIASTRAHMYACISGAVGALSGELHGGANVQVMKMLLEIADPANVDKWVASRLQSGGRIMGMGHAVYRTTDPRADVLARLSKEISREKNNKWYEITERVERATKKYMLEHKRQAIYPNVDLYSASLYYSMGIPMDLNTPIFAISRIAGWSAHVIEEKFAEAAPKPALYRPKAVYVGKYCGPMGCEYTPLSGRQEQQHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICT8</accession>
    <name>K0ICT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hemerythrin HHE cation binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c05320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05320"/>
    <dbReference type="EnsemblBacteria" id="AFU57475">
        <property type="protein sequence ID" value="AFU57475"/>
        <property type="gene ID" value="Ngar_c05320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05320"/>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-530-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="209" mass="23838" checksum="A55679713F55B528" modified="2012-11-28" version="1">MRKKDTMSFFPQPPSSTAGQVTASLRQDHDIIKKVLKATDACIKLLKEGKEIPPAILLDTVDFITNFIDRCHHAKEEQGLFPALEATGMPRENSVIGTMLREYEEARKIAEHIKNAVESHIQDKSEESRSKIIQYCEAYVNHIDRHILKEDTRLFIITERRLKGKENDVKKMVDSVEIEKVGGAEGRKQYEENADRFLSSVRQLGSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICV4</accession>
    <name>K0ICV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57495">
        <property type="protein sequence ID" value="AFU57495"/>
        <property type="gene ID" value="Ngar_c05520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05520"/>
    <dbReference type="HOGENOM" id="CLU_1745601_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-550-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16492" checksum="2427DE9E510B7F20" modified="2012-11-28" version="1">MWNYQKPVHNMERGRSSLLIKRQLAIIGSIAAVAAVALFMTIFSFGADDSFSITEIPFFFMNGQEITVRGTFEECAPTKMLLICYPGFRSDDGNYFVLTDHDTKDLRSLIKQGHFQVTGKFSPEIPEEFAAADVAGVISVSSITPIDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICY7</accession>
    <name>K0ICY7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59231">
        <property type="protein sequence ID" value="AFU59231"/>
        <property type="gene ID" value="Ngar_c23050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23050"/>
    <dbReference type="HOGENOM" id="CLU_1292063_0_0_2"/>
    <dbReference type="OMA" id="MNDGIQK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2303-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="23313" checksum="C0440546763A062D" modified="2012-11-28" version="1">MFATDTGSERATSIEDYQNTCTEFITDISRDYMDWVDRYQLGEQETARRKAAISSIVKTTNDWIVKYGNTIKKVDIVMNDGVNKMAESTAGYPFNFDIFVNKMKRYTTHPVGEIRMNIRAMPRPGRLARVGNYHKDQLLLVNASSPVNFSLSKESMKGADILDDYVIIDAKGCQKHDLISLTAVVEEVEGDYVTESRGYSTLILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDA0</accession>
    <name>K0IDA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59371">
        <property type="protein sequence ID" value="AFU59371"/>
        <property type="gene ID" value="Ngar_c24470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24470"/>
    <dbReference type="HOGENOM" id="CLU_3003267_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2445-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6322" checksum="DD061A56A8781E6F" modified="2012-11-28" version="1">MGKVVMQLVCDTCGKVLLEKPGVSEERFPITSEEAQQLDKDHRGHECHIEAVEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDK6</accession>
    <name>K0IDK6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57760">
        <property type="protein sequence ID" value="AFU57760"/>
        <property type="gene ID" value="Ngar_c08180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08180"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-816-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9163" checksum="78AD6CCBF32EEB02" modified="2012-11-28" version="1">MRDVLQTAMGPGAGISRIMFSACLSHSQATAYLQQMMEDGLVVNDIEQGKKYYRTTPKGVEYLAALNRMCELLQMETRASEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE36</accession>
    <name>K0IE36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58035">
        <property type="protein sequence ID" value="AFU58035"/>
        <property type="gene ID" value="Ngar_c10930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10930"/>
    <dbReference type="HOGENOM" id="CLU_2911646_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1091-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="7189" checksum="57CBCD431EF23217" modified="2012-11-28" version="1">MKKWSEFYSGKILEYDAGATRLVQLRLFGSNLKPNEPIPYFKPVNPTVKIYFTVHILLKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEC6</accession>
    <name>K0IEC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c02040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02040"/>
    <dbReference type="EnsemblBacteria" id="AFU57153">
        <property type="protein sequence ID" value="AFU57153"/>
        <property type="gene ID" value="Ngar_c02040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02040"/>
    <dbReference type="HOGENOM" id="CLU_1335111_0_0_2"/>
    <dbReference type="OMA" id="MEMMQMN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-204-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="23144" checksum="EC474DD04223D326" modified="2012-11-28" version="1">MNFQDLLMQFFSPQYTTNPWFPDMLSATIVALIIAVAMNFAFAMLRKKTTDIEKMNRVMKETNEWRKQYTEAIKKQDKPRIEELKKKQAYVNKMALEMQQQQMRPMLIYMVPSFLIWIFVFPAIFGGTVAMSPIELPFVTCSQDNVNTDTQTRTNEDGTTALTGPCRIPGQVYLWGWFLIGSFGFSGIISKITKTSMPSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IED1</accession>
    <name>K0IED1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27650"/>
    <dbReference type="EnsemblBacteria" id="AFU59686">
        <property type="protein sequence ID" value="AFU59686"/>
        <property type="gene ID" value="Ngar_c27650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27650"/>
    <dbReference type="HOGENOM" id="CLU_2010161_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2765-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="14026" checksum="48171EA0E84E96D3" modified="2012-11-28" version="1">MVIKLILEKQRYVVHALADPRLALEHIEKGCKDCSIAVSDIRMPHMTGLELVKYLKKIRPDLRIILMMAFPDYHKCIHIFWSRLPIRTCAIFGILSGTNPDEPRIDHPLRDFLILLAPAGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEI4</accession>
    <name>K0IEI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59756">
        <property type="protein sequence ID" value="AFU59756"/>
        <property type="gene ID" value="Ngar_c28360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28360"/>
    <dbReference type="HOGENOM" id="CLU_2949427_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2836-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6869" checksum="CEAE1BB343FC79E2" modified="2012-11-28" version="1">MPRINLTVNDDNYQFLKQMKDSGRAASLSHAVRLAIQEYRKSVARKSRDGENKRRFDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IES8</accession>
    <name>K0IES8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_OrfB_IS605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59861">
        <property type="protein sequence ID" value="AFU59861"/>
        <property type="gene ID" value="Ngar_c29430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29430"/>
    <dbReference type="HOGENOM" id="CLU_032903_4_6_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2943-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9605" checksum="696FA08B76C26813" modified="2012-11-28" version="1">MLNYKFRLYPVMEQEQRLVKVLEINRIMYNYFILNNFRSRNDMNFALTELKEQQPILRNYYSKMLRMISTTVAAAWMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF24</accession>
    <name>K0IF24_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57403">
        <property type="protein sequence ID" value="AFU57403"/>
        <property type="gene ID" value="Ngar_c04570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04570"/>
    <dbReference type="HOGENOM" id="CLU_2165343_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-456-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12353" checksum="06F1512167EAA328" modified="2012-11-28" version="1">MVPTFFEPFARDLIQLSNLEQTSGSILDVACGTGILSYLVADSHNIIVRRVVVGIHVNPSMLRMARHSYSRKSIEWIEGSAISLPFPDDESFILVMCQQGLQFFPVGFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFE2</accession>
    <name>K0IFE2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60086">
        <property type="protein sequence ID" value="AFU60086"/>
        <property type="gene ID" value="Ngar_c31700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31700"/>
    <dbReference type="HOGENOM" id="CLU_1998816_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3170-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="13257" checksum="88E57174CD786BAA" modified="2012-11-28" version="1">MAHTGNLPHAVVFALPLRDDGKIYTGRVTFTASKPIEVEVLHVYNPDQTPDAEHGAPPTAVINGTTITYSHLTGIVDNNYVLGDVPTASGTFEFAGSGLVFHKRSSEPFTVTYTIDAAARSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFI5</accession>
    <name>K0IFI5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58575">
        <property type="protein sequence ID" value="AFU58575"/>
        <property type="gene ID" value="Ngar_c16420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16420"/>
    <dbReference type="HOGENOM" id="CLU_2285136_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1640-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11950" checksum="B2A3E9656FA1D32A" modified="2012-11-28" version="1">MTDRGFKVDILNDSVKFYLPRVEGYLEIVRDMAFRYKGMSLIEFDGYFEGKMEPTKYTRVEIHTNDVDENKMTEVANELRIRLKQKSLAFEFNNKLILVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFM5</accession>
    <name>K0IFM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60166">
        <property type="protein sequence ID" value="AFU60166"/>
        <property type="gene ID" value="Ngar_c32500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32500"/>
    <dbReference type="HOGENOM" id="CLU_165240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3250-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="11296" checksum="9536326DF61563B7" modified="2012-11-28" version="1">MLAGLFAISSHGDASAQYGGSGAAGGQVTQEQLARCEELGIERSQCTDVNILARERLTAAQENPSSGSGTPMLSTETGQMAVFIGILGAIFGGVAAIFFFKGRGSKPITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG08</accession>
    <name>K0IG08_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">bPH_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58720">
        <property type="protein sequence ID" value="AFU58720"/>
        <property type="gene ID" value="Ngar_c17870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17870"/>
    <dbReference type="HOGENOM" id="CLU_2243945_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1785-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_3" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="12012" checksum="E0744C65A63E14CD" modified="2012-11-28" version="1">MLFNIKQRKYRPSINIESATITNKRIILRRPSMLRIKKSYVDYSYGDITNIVLDKGPLRSTIMLNLKMDANDLVLEDIPNEMAQQAFRLIREGIDRAREAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG98</accession>
    <name>K0IG98_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase/reductase Sdr</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdr4</name>
        <name evidence="2" type="ordered locus">Ngar_c35180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35180"/>
    <dbReference type="EnsemblBacteria" id="AFU60431">
        <property type="protein sequence ID" value="AFU60431"/>
        <property type="gene ID" value="Ngar_c35180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3521"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_2"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="26999" checksum="8881F239DE523491" modified="2012-11-28" version="1">MTIKGKVAIITGASSGIGYATALALSKAGAKVAAGARRTDRLESLQSEIAKNGGEVFIQRLDVTKKQECDAFVDAVIKKWGTVDILINNAGLMPLSFFKNLKVDEWDRMIDVNIKGVLYCTAAVITHMINKKSGHIINISSVAGRTVFPAGSVYCATKHAVVAFSEGLRQEVSQRANIRVTCIEPGVVATELLNTITDKSLEKYVQTTKQQEAQQLQSEDIANAILFAVQAPDHVSVNEILIRPTTQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR1</accession>
    <name>K0IGR1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma-54 factor interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20890"/>
    <dbReference type="EnsemblBacteria" id="AFU59020">
        <property type="protein sequence ID" value="AFU59020"/>
        <property type="gene ID" value="Ngar_c20890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20890"/>
    <dbReference type="HOGENOM" id="CLU_1149844_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2087-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="45"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="241" mass="27465" checksum="0122DC185DD71EC8" modified="2012-11-28" version="1">MVSAEEDELPVGVHGERVSEPVAEKLSKQEPLFDSIVGYDDVKRLFQMSLSSDKPVHILLVGPPASAKTLFMLECMKLERSYFTLGSHSTKSGMIDYLFEKRPRYLIVDEIEHMPMKDQTALLSLMETGIVSETKFQKTRNTQLKTWVFATSNGTDRMLTPLLSRFVVLHFKQYSFGSFQKVCMHILGREGVAPDIAIAIAEAVWMRLKSKDIRDCIKIGRLAKTKQDVEWIAQTLKTYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR2</accession>
    <name>K0IGR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57012">
        <property type="protein sequence ID" value="AFU57012"/>
        <property type="gene ID" value="Ngar_c00620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00620"/>
    <dbReference type="HOGENOM" id="CLU_170073_1_1_2"/>
    <dbReference type="OMA" id="MAHKTIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-62-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9288" checksum="7A06C861897EC683" modified="2012-11-28" version="1">MASKTIMISEEAYEILKKRKRPNESFTDVIIRLGYEKGSAKRLLELAKSREPISSDTAKIMEETSREFRKNFKTRDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGT9</accession>
    <name>K0IGT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58058">
        <property type="protein sequence ID" value="AFU58058"/>
        <property type="gene ID" value="Ngar_c11160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11160"/>
    <dbReference type="HOGENOM" id="CLU_1801756_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1114-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="15368" checksum="DE1CAEBD3DFB0D6B" modified="2012-11-28" version="1">MPTKVIIFAVAISALILGGTVMVFGLTAYYNSISNDAQTAAPPPPKDPHLLLPIAETKENSDKEEEQQQQQLTGKLSLYILPLDYGVRYQSSEIVSRIGNSLLPKITAAYYTTSGASPQGSHTFESVTLTEQNIAANLKADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGZ1</accession>
    <name>K0IGZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC1</name>
        <name evidence="1" type="ordered locus">Ngar_c01420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01420"/>
    <dbReference type="EnsemblBacteria" id="AFU57092">
        <property type="protein sequence ID" value="AFU57092"/>
        <property type="gene ID" value="Ngar_c01420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.142"/>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_2"/>
    <dbReference type="OMA" id="CESCMRR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="250" mass="27601" checksum="ABD4AF38EF5CF659" modified="2012-11-28" version="1">MTRPAAVCIVSGGLDSVCYAASLAANDGYDLYLLTFVYGQRAKREIERARFFAKVLKARDHKVVDISFMKSLYGRSNALTDNRQELSRDFSQSLVVPVRNAVFLTIATAWAMSINAKVVAYGAHTGDIPHYPDCRPAFVNAINEALNIAESDSIIAGKRQEITVLSPAVMGLDKPALLKAGYKVLGDKIFQTWSCYSDGVRAGKKYLHCGSCESCINRKDAFTTARIEDKTDYATESRSKRKGKAKRDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF7</accession>
    <name>K0IHF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58333">
        <property type="protein sequence ID" value="AFU58333"/>
        <property type="gene ID" value="Ngar_c13960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13960"/>
    <dbReference type="HOGENOM" id="CLU_3323104_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1394-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="38" mass="4696" checksum="D1B5620A123304A8" modified="2012-11-28" version="1">MTERTYFCKSCKAMLFSFSDMRKYMSHRQATKKNIMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ1</accession>
    <name>K0IHJ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nrgA1</name>
        <name evidence="10" type="ordered locus">Ngar_c14320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14320"/>
    <dbReference type="EnsemblBacteria" id="AFU58368">
        <property type="protein sequence ID" value="AFU58368"/>
        <property type="gene ID" value="Ngar_c14320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1398"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_2"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="76"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="496" mass="52081" checksum="7E2A1851B22FEEFA" modified="2012-11-28" version="1">MADGKVKTLSSKIAVLGLASVLAALVAINFSGTALAYTPDDPAAVYHLWETDEEGNYVLDEEGNLIPAAIDTGDHAWMLTSSALVLMMTPAGLAMFYGGLARQKNAVNTIHMVFITTGVIAVQFTLWGYSLAFGPDATGHGFIGTLDWAGLQNVLHDAPSSQYAVTIPHTSFVVFQMMFAIITPALIVASVAERMKFSAFIIFIVIWATFVYDFAAHWTWQIAAPDNYGRNPDYCGFGWTGCLGSLDFAGGTVIHITSGWSGLVIALMLGRRLGYGKMPMEPHNVSLVVLGAALLWVGWFGFNAGSAGAAATNASSAFMATQIATGMAAVTWALVSWGHTGRPSTVGAASGAVAGLVAITPAAGFVSPMSAIVIGILAGIVCYAAVAFKNRRKWDDALDTWAVHGIGGLAGAILTGVFAEARFTSWGDNGLAFGNPAQLYENAVGAFAALAWAMGITAIIIKVMDVVWPGGIRVTPKEEEIGLDLAQHGERAYVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP2</accession>
    <name>K0IHP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58453">
        <property type="protein sequence ID" value="AFU58453"/>
        <property type="gene ID" value="Ngar_c15190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15190"/>
    <dbReference type="HOGENOM" id="CLU_2271124_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1517-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11536" checksum="815D2B58B7942085" modified="2012-11-28" version="1">MGRVGKYHSLRLYNMLEDAFITIKSNSPQACQMAYTGLPCGCMMQWDEDETAVVFCSRHTVDYITGKEAIGTCQNDSHAKRQGWQEVACKDDAVKAFILFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV6</accession>
    <name>K0IHV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydroxypyruvate reductase</fullName>
            <ecNumber evidence="3">1.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ttuD</name>
        <name evidence="3" type="ordered locus">Ngar_c16000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.81" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16000"/>
    <dbReference type="EnsemblBacteria" id="AFU58533">
        <property type="protein sequence ID" value="AFU58533"/>
        <property type="gene ID" value="Ngar_c16000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16000"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1568"/>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_2"/>
    <dbReference type="OMA" id="GKAAWRM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="337"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="449" mass="48047" checksum="BF943C8822A7BCAE" modified="2012-11-28" version="1">MITNKRELTTFHSDRSSHLVLGALEAAVDSVMPAALVKHAVKFEKELSVRDINGKIIRLRNFDRVYIVGAGKATAGMAGALVPMLQDRMAGGAITVPYGIKAKIKGISITYASHPVPDRSGMEGTKKILNVLKKVQKNDLIFVLISGGGSALMPLPAPGVSLANKQKITNLLMRSGASIHEINAVRKHLSAVKGGQLLRHIDGACTVVSLILSDVVGDDLEVIASGPTCADRSTFADALKILKKYRIKDPDAALAHIADGAKGNIEETPKPQDPVFSHVHNMLIGNNTIACTSAISYLKKRKVQAVHLGSEFDGEARDFGTFLARLASDLSNSKPFAIVTGGETIVRLNKSKSGTGGRNQEAAMAYMMELRRQHDVAAAFMGTDGIDGNSDAAGALVSPKTITNAKKMNLKKYLDNHDSYHAFKRLRSLIFTGYTGTNVNDIAIVCKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0II04</accession>
    <name>K0II04_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59560">
        <property type="protein sequence ID" value="AFU59560"/>
        <property type="gene ID" value="Ngar_c26380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26380"/>
    <dbReference type="HOGENOM" id="CLU_2613749_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2638-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8597" checksum="ABCC69E0B9728FC7" modified="2012-11-28" version="1">MKNEFLAVENIIDREDGKARYTMFVNAYNMDREHGGIGGLTPQERWSQLQLLNTPTRNRNRLRSVTHLCKYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0II65</accession>
    <name>K0II65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c27090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59630">
        <property type="protein sequence ID" value="AFU59630"/>
        <property type="gene ID" value="Ngar_c27090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27090"/>
    <dbReference type="HOGENOM" id="CLU_2152691_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2709-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="13039" checksum="9779BED70BE50678" modified="2012-11-28" version="1">MSDSEFMVSPDISEEKPPIDGVYSNVDSMIRQQWYVFETIWNHVVPVEERIRELESEISDTQQDADTSKKGKAIDRFYVCEHCRLVFILGEEVDEHKMLTGHKKMKEYPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II76</accession>
    <name>K0II76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17250"/>
    <dbReference type="EnsemblBacteria" id="AFU58658">
        <property type="protein sequence ID" value="AFU58658"/>
        <property type="gene ID" value="Ngar_c17250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17250"/>
    <dbReference type="HOGENOM" id="CLU_135994_0_0_2"/>
    <dbReference type="OMA" id="AEHASTF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1723-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15563" checksum="E9DB9EF52170E5A5" modified="2012-11-28" version="1">MVQDEVIFYGHPNVQSLHGKTVEITKDEHLTLRGDCIIGVRASKACADLDETLKRRLASNDSVVSIEIMVGSETFVINGRGDERISLQNPHDIVIRKTNFVCPRTLSVRCDKASSDVPRKIVKMLQDKDAKGIFRITIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA7</accession>
    <name>K0IIA7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl6p</name>
        <name evidence="3" type="synonym">rpl6</name>
        <name evidence="5" type="ordered locus">Ngar_c17450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17450"/>
    <dbReference type="EnsemblBacteria" id="AFU58678">
        <property type="protein sequence ID" value="AFU58678"/>
        <property type="gene ID" value="Ngar_c17450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1719"/>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_2"/>
    <dbReference type="OMA" id="VFQDGIY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_L6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_L6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20658" checksum="CA9DBE5189C8CA49" modified="2012-11-28" version="1">MATSTDQEMIMAEVEAPASVKITKEGNVLSVKGKLGTVKKDFTKLPATITVQGNKVTIKPYGTRKRDLAVTHTARSIIESMIKGVEKGYTYKLKIIFAHFPISVKVKGKEVNVENFFGERSPRVSRIVGDATKVHVVGEDVVVQGPSLEDVSQTAANIELSTRIKDKDQRVFLDGLYVYSREEGMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE6</accession>
    <name>K0IIE6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59685">
        <property type="protein sequence ID" value="AFU59685"/>
        <property type="gene ID" value="Ngar_c27640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27640"/>
    <dbReference type="HOGENOM" id="CLU_2420148_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2764-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10516" checksum="82A8D89FCEFB21E4" modified="2012-11-28" version="1">MLASEGSSDSARDFLIKEVCLWIAIQQQTSFWQIIQHCSAMAFVVQFWGAHWHSAHLITAMMDYANNEFLDIKTCYPQIKFPAPSKMQNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG6</accession>
    <name>K0IIG6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative blue (Type 1) copper domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c18860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18860"/>
    <dbReference type="EnsemblBacteria" id="AFU58818">
        <property type="protein sequence ID" value="AFU58818"/>
        <property type="gene ID" value="Ngar_c18860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18860"/>
    <dbReference type="HOGENOM" id="CLU_051300_0_0_2"/>
    <dbReference type="OMA" id="TFIDGMH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1884-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="4">
        <location>
            <begin position="186"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="3">
        <location>
            <begin position="332"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="411" mass="42682" checksum="5C430DD51C512FF2" modified="2012-11-28" version="1">MSDWDLLTPGIGLTSIGIVGVAISLSGIAKTFIDGMHAVSLLTMFIGMIFLASGLFKDGFPSTGRAKSATFITLGFLVTFGFAAAVTVSTQVPSIYAYIGLMLIISIPAAVLAFASYKQIPYIKALAVIFIGAAVVGGSTFYAFGLVTPRPPAPPEEEEPAEEPAPPANIINATILAGASAQGNPDYEPDPITVNKGDGVRWVNEDNVPHTVTSRQEGVFDSSIINAGGNWLLNTAELDSAEYEYFCTLHPNMVATLTVTEGGAAAPAEGSGNATAPENATAPEGSSNNQSSTTSNETTASTPNATTGGSGASVTSVSIVVGSSVPTNGEFYNPENVETTVGSMVAWTNDDSVPHTVTSGVVENNSPKPDGKFDSSIMNHGASFRFVFDEAGEYPYYCSLHPYMTGKVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM7</accession>
    <name>K0IIM7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19860"/>
    <dbReference type="EnsemblBacteria" id="AFU58918">
        <property type="protein sequence ID" value="AFU58918"/>
        <property type="gene ID" value="Ngar_c19860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19860"/>
    <dbReference type="HOGENOM" id="CLU_115699_0_0_2"/>
    <dbReference type="OMA" id="GCSDCRC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1984-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10441">
        <property type="entry name" value="GIY-YIG_COG1833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="16270" checksum="F8D142B5271A4BE9" modified="2012-11-28" version="1">MNGVYVLLMHIGRPVTARTGSLGRLRFEKGVYAYVGSALNGLEPRISRHLSKRKENMHWHIDYLTSSPYASIEYAIMGETSKRVECKVSKAIASKTFSNRVPAFGSSDCNCNSHLYRIDMSIDESLQEMKEIFSVLGLSPITLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR5</accession>
    <name>K0IIR5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59835">
        <property type="protein sequence ID" value="AFU59835"/>
        <property type="gene ID" value="Ngar_c29160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29160"/>
    <dbReference type="HOGENOM" id="CLU_2392991_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2916-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="11289" checksum="66804F54BC93252E" modified="2012-11-28" version="1">MKMANIRFDDPEDLGRPSRVFIELMMRLELLDYARRYFERKGDSSSLKRAGEIRKFYKQTICDSVYIVRSIIPDELMHEHSKLFCKRIRKERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV2</accession>
    <name>K0IIV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20820"/>
    <dbReference type="EnsemblBacteria" id="AFU59013">
        <property type="protein sequence ID" value="AFU59013"/>
        <property type="gene ID" value="Ngar_c20820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20820"/>
    <dbReference type="HOGENOM" id="CLU_1451451_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2080-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="186" mass="19130" checksum="DC0BF251E8EB40F6" modified="2012-11-28" version="1">MFVLPLSNGENFRFNPDPAAAVVIATTALPFMSALIFLVSARAVGKQGAASTAAGVVIGMNVLANIVPAYQFLGALLPWQLLAVIPAIVGADIAIHRTGPRAGMIVAGALIGVTFHIFNFPMLPMAFAELLGQPNETIGDILPSIYATLSQVTAVTAAPSVLAGIVGAIMGSKKIEVPQVNVAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX0</accession>
    <name>K0IIX0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="16">BCAT</shortName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ilvE1</name>
        <name evidence="16" type="synonym">ilvE</name>
        <name evidence="17" type="ordered locus">Ngar_c21070</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 16">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 16">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21070"/>
    <dbReference type="EnsemblBacteria" id="AFU59038">
        <property type="protein sequence ID" value="AFU59038"/>
        <property type="gene ID" value="Ngar_c21070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2088"/>
    <dbReference type="HOGENOM" id="CLU_020844_3_1_2"/>
    <dbReference type="OMA" id="GMQCYEG"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFU59038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="311" mass="34690" checksum="AAEA6B9A5F14BF6E" modified="2012-11-28" version="1">MKEKGGEFVWFDGKFVKWEDAKVPVFTHALHYGTAVFEGIRGYAAKNNLYIFRLQDHMERLHRSAGVYSISLNYSAKELASATVELLQKNKMKESCYIRPLTFVGLHGIDLNVTKSSPTHTVIITFPFAKYFKGEGIKVCVSSWRRINDSTTPPLAKAAGNYLNSIMATQESKRNGYDESILLDLSGNVSEASGENIFLVRRGKIYTPHLADSALEGITRESAIKIAKDLGYEVTERPISRTELYMADEIFLTGTAAEIVSVSSVDGHVVGNNGKEGPVTKGIREMYEKIVSAGAKEYMNWLTPVWQTQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ36</accession>
    <name>K0IJ36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58162">
        <property type="protein sequence ID" value="AFU58162"/>
        <property type="gene ID" value="Ngar_c12220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12220"/>
    <dbReference type="HOGENOM" id="CLU_2985798_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1220-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6530" checksum="886447C5894AD2B8" modified="2012-11-28" version="1">MSHKKEIEEPLDVEQAKELELDEMPKPTRKVSNPSVPVPDNAEPSTHDRIKGRRVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB7</accession>
    <name>K0IJB7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58347">
        <property type="protein sequence ID" value="AFU58347"/>
        <property type="gene ID" value="Ngar_c14110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14110"/>
    <dbReference type="HOGENOM" id="CLU_2968574_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1409-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6373" checksum="D19020204BE766B2" modified="2012-11-28" version="1">MAPGKFQCSCGKTIEYIDRVVGGNNAQSTTLVCSKCQKEHQITFYGFLSEIKGASIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH2</accession>
    <name>K0IJH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S9p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps9p</name>
        <name evidence="4" type="ordered locus">Ngar_c23930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23930"/>
    <dbReference type="EnsemblBacteria" id="AFU59318">
        <property type="protein sequence ID" value="AFU59318"/>
        <property type="gene ID" value="Ngar_c23930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2364"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17139" checksum="291D992C0D7A9E73" modified="2012-11-28" version="1">MEGRAIIMTNKVELYPGQRKSSRAVATIAKGSGKVRINNTPAELITPDIAKEMVLTPLTLVGDYRNKVDIDVQVHGGGFMGRAFASAVAISRALTGQEKGGKDPKEHPFTKSVREEIRKKITEYDRHLLSGDSRQTESKKFGGPGARRRKQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJP7</accession>
    <name>K0IJP7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33700"/>
    <dbReference type="EnsemblBacteria" id="AFU60285">
        <property type="protein sequence ID" value="AFU60285"/>
        <property type="gene ID" value="Ngar_c33700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33700"/>
    <dbReference type="HOGENOM" id="CLU_1575002_0_0_2"/>
    <dbReference type="OMA" id="VSAMHIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3370-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="18898" checksum="7E8624E777D01443" modified="2012-11-28" version="1">MGFLALFGENDMIDITDRVADAIKDGGIKDGIVTIFVSGSTAAVATIEYEPGLRKDFPAMLDRVAPKAIEYEHDNTWHDGNGHSHVRASLIGPSLTVPFKDKRLMLGTWQQIVLMEMDTRARARNYFANNGRIIRTPTQTISRHIIYHSCGREANGDPPTHQYMLFPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ6</accession>
    <name>K0IJQ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60305">
        <property type="protein sequence ID" value="AFU60305"/>
        <property type="gene ID" value="Ngar_c33900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33900"/>
    <dbReference type="HOGENOM" id="CLU_2067884_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3391-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="13947" checksum="F23DE3D1C38524C0" modified="2012-11-28" version="1">MFVNLMSEKEKEDDLAQELDAILDSYDKNNEVKQDNVDEEQIQEFLARFERIKVETIRPTMEQVGKYLEKRGHLYQIKDKADIHEDNPSITMEIYPRTSNDVPIQEHEFPTISFIANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ9</accession>
    <name>K0IJQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c25300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25300"/>
    <dbReference type="EnsemblBacteria" id="AFU59453">
        <property type="protein sequence ID" value="AFU59453"/>
        <property type="gene ID" value="Ngar_c25300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2508"/>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2529-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="69"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="352" mass="39629" checksum="06F9AD8972C3C5FB" modified="2012-11-28" version="1">MPGKDAELFTALPNGRVRCTACARLCEIPEGKVGLCGIRGVVNNKLRLFVYGRVIAGHIDPIEKKPVTHYMPGTDIFSISTTGCNWLCQYCQNYDISQRRKVEGAEMTPEQVAETAARYGSQGIAYTYNEPSIFIEFARDCGIEAHKRGIFNIFVSNGYDTPESVGMMSQFLDCITVDFKGNGEQKFVRRYIGIPGSDPIFQTLKEIRDKTKIHVEITDLVVPQVGDDLEAARKLCRFVHDELGPDTPIHFLRFHPDYKMMEFGNTPVETLEKHHAIAKQEGLKYAYLGNVPGHPLEDTYCPECKSLVVGRYGFAIESWNLDGNNCCKNCGYPIPIIGKLRKARKNLFQFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX1</accession>
    <name>K0IJX1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59523">
        <property type="protein sequence ID" value="AFU59523"/>
        <property type="gene ID" value="Ngar_c26010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26010"/>
    <dbReference type="HOGENOM" id="CLU_154322_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2601-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="18429" checksum="630CF6327BE83488" modified="2012-11-28" version="1">MVISDKPRVGKAQKKKWIDLINESVHSSDDIDIGDIDAVSRDFVVVKRGFVNVHYYYIPMGKVEGWDGDVLWLKVPEEYVKRNYERDILPDPSRYYMKEFPGYTAVFPEVEVILPKYTTPVYTAKHTTPEDFRVYLCELCRTAFDTEDDLSQHVSTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK16</accession>
    <name>K0IK16_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstS2</name>
        <name evidence="5" type="ordered locus">Ngar_c35570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35570"/>
    <dbReference type="EnsemblBacteria" id="AFU60470">
        <property type="protein sequence ID" value="AFU60470"/>
        <property type="gene ID" value="Ngar_c35570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35570"/>
    <dbReference type="HOGENOM" id="CLU_649922_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="4">
        <location>
            <begin position="101"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="369" mass="39844" checksum="F994D0AE43E3CD74" modified="2012-11-28" version="1">MVAIVVAAIAAIAMVVLAAVALLQPRPEAPGDGGTIVANGTEPAPKEVVGVMSARSAFPFVQRWASQYNNDENALGSIELNYYLERPNALGDLMIIEDVRHAASGSHNIPVSAQAAAIVYNIPSFPDVPSGLKLNATILSSILDGTVTRWNDPAIRDLNQNLNLPAERIVVVHENRNSSTLALLERYLSAEEDNNIIRWPDNSVGVIGPDELAATVRQTPYSIGYVDFSYATQTRMTFAAVANSHGEYILPSADSIWQAVNSSMQVQNITGVINQAAAIPPFLNASMFGNSSYPLTGLYYASLPGDDDMLEDTTKNATLDFVKWMIDRDNGQQTLSEVQYPAIYQDNGPLARYAEAVINSTAARVSKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK24</accession>
    <name>K0IK24_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35670"/>
    <dbReference type="EnsemblBacteria" id="AFU60480">
        <property type="protein sequence ID" value="AFU60480"/>
        <property type="gene ID" value="Ngar_c35670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35670"/>
    <dbReference type="HOGENOM" id="CLU_096711_0_0_2"/>
    <dbReference type="OMA" id="NDYLWHE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3568-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="295" mass="32876" checksum="9484EF9CF4B5BD1A" modified="2012-11-28" version="1">MTQSIAFHSYKGGTGKTTIACNLAAMLATKGYNVSMLDLDVYAPSLHAYFEKTPYKWINDLLSDNAKIDDVMVDMTSVIEEYAGLGKKGGKLWIGFSNPQKEEVYKLEGGGGKQANAKIQLLRKFIQLREDLISEYDSDYIIIDTSPGIRFWSINSLAIADTLFLTLKLGDLDIEGTRKMANDIYGSFTKFGAKSYLLLNRVGGYCVPNTPIVPRNNHHRSEEEGNDAVALPPQYDEADLGKSLSDEVSMDLISAIPCYCDIQFSRKEFLTVLQYPNHPFAKQLEKLATAKQIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK29</accession>
    <name>K0IK29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative SMF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17140"/>
    <dbReference type="EnsemblBacteria" id="AFU58647">
        <property type="protein sequence ID" value="AFU58647"/>
        <property type="gene ID" value="Ngar_c17140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1689"/>
    <dbReference type="HOGENOM" id="CLU_029601_3_4_2"/>
    <dbReference type="OMA" id="NEQCIAV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1712-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="25483" checksum="E8FEE7BDD10FED04" modified="2012-11-28" version="1">MGTADGAQGLVLTVEELLGRPLNDIEKKYAPKILYVKGSMRIPLPRPRVSIVGSRKASEEGLHAANRIASTLVKDGVVIVSGLAEGIDTSAHQAALESHGRTIAVIGTPLNKVFPAKNYQLQQEIMNNHLVISQFPIGHPTRPKDFVLRNRTMALISDATIIVEAGEFSGSLHQGWEALRLGRSLFIWKSILENKKLTWPRKMMQYGAMELSNPEDVLEVLPSDLQMPLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK65</accession>
    <name>K0IK65_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59618">
        <property type="protein sequence ID" value="AFU59618"/>
        <property type="gene ID" value="Ngar_c26970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26970"/>
    <dbReference type="HOGENOM" id="CLU_494028_0_0_2"/>
    <dbReference type="OMA" id="LMELIFY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2697-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="546" mass="61034" checksum="24A4BB93CB4FF50F" modified="2012-11-28" version="1">MSSSSSVSPQEFEVIKKCIVKVAKGCAVVAACFYGSRVAGYARPDSDIDVLVVLENYPYVVKYVYFSESGVKLSALAVDRAALERDAKNAFLGEFVVGRLLHIYEPITNADFFAQVEQAYKRRVILEEVQDIVCLTGVLGTEIIFPLEYVVFSKIRRRMSLYPSAAYSYYKTYASSNERNLEFALGGYRRALADIVSEDRELFAARQDGLLQVSGKRVFVEGGQTRLKLTKRLQEFSSYFVHTYAGRKIMHLAVSEAESKIRRHHTGKDVEMPYFMACPKGAYWTLPEGRLIVGSRDWLGDLGYSVARKKRLGNVNSRTVLYMLEDGRKVVVKELAKSKAVKWAALSLWTAPVKRFRVDPLFRLGSEYKAIRYIRSLGLRTPAIEAVVLDRKILVTQFIEGRTLASVIKDYIRGRGDDIALIGKAGAQIARIHSAGSTLGNVKPKNVIASSGSGDQYFTDVEQFMFQAGDPAWDLAQFISWGLKGTSNSSMAAKITREFLKGYVDIAGYGNVARLAKSRRYIESFYPVLAPSVARAIKKEIKEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK83</accession>
    <name>K0IK83_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58702">
        <property type="protein sequence ID" value="AFU58702"/>
        <property type="gene ID" value="Ngar_c17690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17690"/>
    <dbReference type="HOGENOM" id="CLU_1253623_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1767-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="220" mass="24855" checksum="8A9981DD7D092F3D" modified="2012-11-28" version="1">MTSSEARFTINVREGVVELEGKESFVDKHLEKFEEIFKMAVKEAITRGLEQNIALKAQPVQAALPQELQHQEIPIAAEQQMAPVQPQPKGGNGKHTPRPTVTIHPIPVDLKANESKVGLREFYAEKKPANHYEKAAVFVYYLTKFNKQQEVRFGEILSCYEEVNEKKPSIVDIVKNSIRYKGWLEQGSEKYTARLTISGENFVKFDLPAQGEKVAQATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ4</accession>
    <name>K0IKQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59097">
        <property type="protein sequence ID" value="AFU59097"/>
        <property type="gene ID" value="Ngar_c21670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21670"/>
    <dbReference type="HOGENOM" id="CLU_2875208_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2165-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7653" checksum="89221D1B13C0326E" modified="2012-11-28" version="1">MRRIILFLFQKLLSWLGNLSKIKMTDVDEKMLDDVHHYFFIKQSWHMYSYLFTSLNIGNKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKV4</accession>
    <name>K0IKV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60018">
        <property type="protein sequence ID" value="AFU60018"/>
        <property type="gene ID" value="Ngar_c31020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31020"/>
    <dbReference type="HOGENOM" id="CLU_2217137_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3102-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="12279" checksum="50972474CF62C8D3" modified="2012-11-28" version="1">MAAIAICHCRPGTEAESGKLLRKVRCYQALARHCQGLWQPLGCVRALRQIAERLAPCSWRQHWPAHAYKKMIERGFRTDMQGVAMQRPNELGYNLPDISYLIDDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKZ7</accession>
    <name>K0IKZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="9">4.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiC2</name>
        <name evidence="9" type="ordered locus">Ngar_c31570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31570"/>
    <dbReference type="EnsemblBacteria" id="AFU60073">
        <property type="protein sequence ID" value="AFU60073"/>
        <property type="gene ID" value="Ngar_c31570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3137"/>
    <dbReference type="HOGENOM" id="CLU_013181_2_2_2"/>
    <dbReference type="OMA" id="FMAIHTG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="445" mass="49073" checksum="495572F1B65514F2" modified="2012-11-28" version="1">MPTQMGSARRGIATEEMIDVAKQEDIDVSVIVQRVANGSIIIPRNNARKQKIKVTGIGKGLRTKVNVNIGTSTLHQNLDEEVSKAKVAVKYGADTIMDLSDGGNLNLIRQTLLEAAPITFGTVPVYQAYCHGVEKYKNPLNITEDDFLNAFEKNAKDGVDYTTIHSGITKELAKRMLEERRHGGIVSKGGTITAAWMLKYDKENPYYEHFDYLCEIARKYDVTFSLGDALRPGSILDSHDELQVAEMINVARLAKRAHDKDVQVMIEGPGHVPLNEVAANVRLAKSLIGDIPYYVLGPLVTDVAAGYDHIASAIGAAVSAAEGVDLLCYLTPAEHLGLPTAEEVKEGLIAYRIAAHAGDLVKIRDKAIKWDRDITEARRTLNWEKQIALSINPEEAARIHYRSSGQHEGNNVPCTMCGSAYVYIMLPQRRKPKDKDKDNTQAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL52</accession>
    <name>K0IL52_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60158">
        <property type="protein sequence ID" value="AFU60158"/>
        <property type="gene ID" value="Ngar_c32420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32420"/>
    <dbReference type="HOGENOM" id="CLU_3263940_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3242-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="41" mass="4395" checksum="716D7217560761BB" modified="2012-11-28" version="1">MRYKFDALGRGLVFLQAASLRHAASGMTAATSADNNNILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL55</accession>
    <name>K0IL55_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
            <ecNumber evidence="6">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">psmB3</name>
        <name evidence="6" type="synonym">psmB</name>
        <name evidence="8" type="ordered locus">Ngar_c32470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32470"/>
    <dbReference type="EnsemblBacteria" id="AFU60163">
        <property type="protein sequence ID" value="AFU60163"/>
        <property type="gene ID" value="Ngar_c32470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3241"/>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="VDKTGPH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="4 6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="5 6" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005066910" description="Removed in mature form; by autocatalysis" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023550186" description="Proteasome subunit beta" evidence="6">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 7">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="20513" checksum="AFD1034A486A3F23" modified="2012-11-28" version="1">MTTIVGIKTKEGVVLGSDKRASKGFFIGSKITQKIAKIDDTLAVAIAGQLSDAEYLIKVAKAERRLIELRRGFPLTVKESARLISNLAYSGMKNYQPYFVELLVAGVDQEGGHIYAADMSGAITSEDFASSGSGSPIAYGVLESMYHKEITNEEAKQVATKAVSAAMERDPGSGNGIDVLVIPNLVVQEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL96</accession>
    <name>K0IL96_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60258">
        <property type="protein sequence ID" value="AFU60258"/>
        <property type="gene ID" value="Ngar_c33430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33430"/>
    <dbReference type="HOGENOM" id="CLU_2565862_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3343-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="8565" checksum="9E1E2FD5258D090D" modified="2012-11-28" version="1">MMMIIIHLRPLLPPVSNKVVAGGGGAPPAGCPPFPLVDSFTAIFEEPGTYPYFYSIHPWMTCEVVVRGGGNDDSTTGTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC5</accession>
    <name>K0ILC5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA double-strand break repair protein mre11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mre11</name>
        <name evidence="2" type="ordered locus">Ngar_c34030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34030"/>
    <dbReference type="EnsemblBacteria" id="AFU60318">
        <property type="protein sequence ID" value="AFU60318"/>
        <property type="gene ID" value="Ngar_c34030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34030"/>
    <dbReference type="HOGENOM" id="CLU_026621_5_2_2"/>
    <dbReference type="OMA" id="HDFSYVR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="394" mass="43732" checksum="3B784C4B8E94A322" modified="2012-11-28" version="1">MLISHISDLHLGYSQFSLEEREEDVYQTFHEAIDISIKEGARLVIFAGDIFHNPRPCGKAIITLGNALKKLKEKQIPAAFILGEHDISRLRDVPFAHIYSNLGLAKKLRHDEPFVVDNCAVFGADKERRSNIDSLIERLRQAEQVAKRHNGKKVLVLHQGLDDFNKFAGELGSNALPASFNYYALGHYHDHIEKRFGHLGGPLAYPGSIDLTPSEGIKEVEKGFIMADMSGEEPSTHWIPLNSRRQQFSVRINYGDIADEVGRIIERAKCFGNKKPVARIEVAGRDIDSKVIAENLKRLNDYCLHYVWQPLEEGRLAATVYDSRPADIDSELYRLSAQALGSDELAKFAVGEILPLAAGRDAAARSVLEIVWQAYKAGKFVGRGEGGGGGSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF3</accession>
    <name>K0ILF3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59462">
        <property type="protein sequence ID" value="AFU59462"/>
        <property type="gene ID" value="Ngar_c25400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25400"/>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="OMA" id="MCDIFIN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2539-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9323" checksum="372FA350F5EAF477" modified="2012-11-28" version="1">MTCKGICIRHKAQKPVGSGRYASGQKRCQICEIFIKWDGLWCPCCGYRLRTKPRNLKYKAKLRARTSGRVEAPPVLTVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF9</accession>
    <name>K0ILF9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Probable cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">cobQ</name>
        <name evidence="8" type="ordered locus">Ngar_c01040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01040"/>
    <dbReference type="EnsemblBacteria" id="AFU57054">
        <property type="protein sequence ID" value="AFU57054"/>
        <property type="gene ID" value="Ngar_c01040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.108"/>
    <dbReference type="HOGENOM" id="CLU_019250_0_0_2"/>
    <dbReference type="OMA" id="PSGNGRM"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="7">
        <location>
            <begin position="8"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="283" mass="30880" checksum="686FB6A95CF3B8E0" modified="2012-11-28" version="1">MAKKARLVMVQGTSSGAGKSTIVIGLCRLFSGKGYKVAPFKAQNMSSNFFATAGGAKMALVQAIQAVAARKEPDPLMNPILLKPIGEYRSIVFLNGRFYSEMHAKEYYEKFVMQQGFSTVLKALDSLRSENDIVIMEGAGSPSEINIAKYDIANMLLAQKVGAPVIIVADIERGGCFASIVGTMQLLKPAHRSLVKGFLINQFRGDITLLAPAIKEVQKMTKKRILGVIPKIEFNLPEEDSLVGSMAGKAEIPREAWNWQIDLVAKAIKESVDMERISEVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH0</accession>
    <name>K0ILH0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adh1</name>
        <name evidence="2" type="ordered locus">Ngar_c01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01240"/>
    <dbReference type="EnsemblBacteria" id="AFU57074">
        <property type="protein sequence ID" value="AFU57074"/>
        <property type="gene ID" value="Ngar_c01240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01240"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.126"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_2"/>
    <dbReference type="OMA" id="SEKMLMH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="352" mass="38507" checksum="5EBC6F9F43A7CB89" modified="2012-11-28" version="1">MKAAVYREYSKDPTKVVKIEDIDIPKIKPNEVLIKVEAAAYNYNDLWGIWGEPIKIPLPHISGSDVAGTIVEVGSDVQKLKVGDRVVSHSNLSCRVCYECTSGREFDCSDRLVWGFQTGPLWGGFAQYTHLPEVNVVKIADNVSFNDAAAVSMVGMTSWHMLVGRAKIKPGQLVLVMGGGSGVGMVGIQIAKLYNCTVIATAGNKDKMDKCLEIGADYVVNHREADWYKKVREINKKLGQPGVDVVFEHIGKSVFPQEVALLKMGGTLVATGATTGYDSTIDLRYLFFRGTNLLGSTQGTKAELEDVMYWVSKGKIKPVIDTILPFSDMVQGHVMMAGAQQFGKILTTPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK1</accession>
    <name>K0ILK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59527">
        <property type="protein sequence ID" value="AFU59527"/>
        <property type="gene ID" value="Ngar_c26050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26050"/>
    <dbReference type="HOGENOM" id="CLU_2968570_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2605-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6391" checksum="FA3AF31950080F4C" modified="2012-11-28" version="1">MGVVMASPDGLEPWKHPASMQAAMIIVEFDRDILVEAGVTVQESFSQRYPLAWMGPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR4</accession>
    <name>K0ILR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03160</name>
        <name evidence="2" type="ordered locus">Ngar_c03460</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57264">
        <property type="protein sequence ID" value="AFU57264"/>
        <property type="gene ID" value="Ngar_c03160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57294">
        <property type="protein sequence ID" value="AFU57294"/>
        <property type="gene ID" value="Ngar_c03460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03160"/>
    <dbReference type="KEGG" id="nga:Ngar_c03460"/>
    <dbReference type="HOGENOM" id="CLU_1830648_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-316-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="16795" checksum="197E0F84118C93BA" modified="2012-11-28" version="1">MIKLLTLKDIAPKWAHRLRKKAEPRIIAENKELIYDYQTCIVTEAHGGKHPYKTPNGKICAECTEAAGLLSYYYRKRDHEEFEITLKRWILHWNARHAGKEYRKAVADWMIKHFKLEDVLNVQRYVDPIIEQFYQRRPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV1</accession>
    <name>K0ILV1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57374">
        <property type="protein sequence ID" value="AFU57374"/>
        <property type="gene ID" value="Ngar_c04270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04270"/>
    <dbReference type="HOGENOM" id="CLU_127465_0_0_2"/>
    <dbReference type="OMA" id="DLWEPRW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-426-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="17528" checksum="BE9FC9461F6C2B69" modified="2012-11-28" version="1">MYLYRQVFSHLHIFGKKQVVNCAVCGKELGRHKYKPGEDWGIEGLLCGDCHIEKTREFMLKQEETPDICAMCGKEIMGDGHKPRWQWEMEQGALLCKLCFDKKDSDYNRKTNFCAICNSKLGLFYYHPKPAWHIEGNLCRKCWDSRNSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM18</accession>
    <name>K0IM18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type 2 DNA topoisomerase 6, subunit A</fullName>
            <ecNumber evidence="7">5.99.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">top6A</name>
        <name evidence="7" type="ordered locus">Ngar_c29790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.99.1.3" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29790"/>
    <dbReference type="EnsemblBacteria" id="AFU59897">
        <property type="protein sequence ID" value="AFU59897"/>
        <property type="gene ID" value="Ngar_c29790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29790"/>
    <dbReference type="HOGENOM" id="CLU_037229_1_0_2"/>
    <dbReference type="OMA" id="NWGEARF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="6">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="368" mass="41730" checksum="EEAFB506DA653FD7" modified="2012-11-28" version="1">MPATDKRHQEVIKKIKTIMKDVSTDLMVQKMMPVLNVPKVGYDNTVWSDEKRMLTIGDKTVGISPDSTKKIPTFTQYLVMANAVRKLLDEEMESTIRGMYYATLSTVGDEKNKQKFWTGQEDSDDAIKAIELLTGVPREEFSVTSKPKGMISGPITLRVGGDVIDCNLGSRATSQLIPTNIRDVEIVKVKADFVMVVEKDTVLNNIRKSGFIQKYNAILMTGSGEPDRATRMMVKALNEEWKKPVVVFADADPWGLGIALRYKIGSESLSYDSDRLVTPDAKVLGMMFSDIYEYNIPEVARLAASDDDLNRANDMKKKPWFQDKQWQKELDLFLKKKEKCELDAFFKHGFKYLAEVYLPRKLREAGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM76</accession>
    <name>K0IM76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60067">
        <property type="protein sequence ID" value="AFU60067"/>
        <property type="gene ID" value="Ngar_c31510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3129"/>
    <dbReference type="HOGENOM" id="CLU_023853_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3151-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="292" mass="33179" checksum="538DE8C2B4E5519A" modified="2012-11-28" version="1">MLELRGIRPAAIQVRTCNSSFDRQAIKELADSIRQHGLIQPITVRPVDSGFEIVAGHRRYQACKLLRWRVIPARIRALSDKDAFEIQLIENMHRMTMDPIEEAEAFKAYILDYGWGGVSQLGRVISKSEQYISSRIQLLRLPKEIMEQVAQKKLKPSHALELVNIGEDKQKLIAEEIMNGGLSVHAVREIRRQIKNGAKVEQIFGFDGTMDDGIAAKETKDGSKSAEIKLLKRALLVLRMSLARLDMIIEEANGKLRSEERAEVVSELMQFRLKLHSMIDDDLKKISLLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA4</accession>
    <name>K0IMA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57694">
        <property type="protein sequence ID" value="AFU57694"/>
        <property type="gene ID" value="Ngar_c07510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07510"/>
    <dbReference type="HOGENOM" id="CLU_124803_5_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-749-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="13487" checksum="305F25612B313DFA" modified="2012-11-28" version="1">MTEMLSFYYEDALTILQELADAISQKIILSTIDTAKPAQQIAADNGLPLSSTYKKIRKLCNMKLLCVDRIQIDNSGKKVFFYKSKIRSCQFYLRQDGPLLQFERNEAACVIEGIRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML2</accession>
    <name>K0IML2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57989">
        <property type="protein sequence ID" value="AFU57989"/>
        <property type="gene ID" value="Ngar_c10470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10470"/>
    <dbReference type="HOGENOM" id="CLU_2165142_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1045-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13678" checksum="48D99F4354FAEC6D" modified="2012-11-28" version="1">MTDSPSSPYARFPVLETIDIREASDIRHAVDRLIESYITQVPEGKFSYRILLPRDPKSTAKAKRIGLAFQGEFVLGLRKRNIVPRVREVRYVHDESHYGWLLANPEVYERFERRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM8</accession>
    <name>K0IMM8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35090"/>
    <dbReference type="EnsemblBacteria" id="AFU60422">
        <property type="protein sequence ID" value="AFU60422"/>
        <property type="gene ID" value="Ngar_c35090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35090"/>
    <dbReference type="HOGENOM" id="CLU_951933_0_0_2"/>
    <dbReference type="OMA" id="WDRENIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3510-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="298" mass="34564" checksum="BEE4FA6CF9B56BD5" modified="2012-11-28" version="1">MNIIRPAKKSDREEILSFCINTFSWGDYIHRVWDYWFRSGRLLVAENEGKKIGMSHVAICPDSKSMWLEGVRVHPDYRRSKIATQLLEKMIEYGKKKGALQASAIVDVTNVASQHMMEKNGFEVVSRWAYYSTADGRPGRKRKKRSAARLATVADLGDIWEYLQNSKIYSLSAKRYVKSWHWYMLDKKVLRSFIRDKSVIIVTGRRPINGIAIINRHGYWDRENILQVVYLDAASVRPLDHLVSFVANIYLDGGFKELQVVCHNSKRLTSFIEKFMAKDEEQFLLYNKVFTAKAAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ0</accession>
    <name>K0IMQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative protease TldD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c11480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11480"/>
    <dbReference type="EnsemblBacteria" id="AFU58089">
        <property type="protein sequence ID" value="AFU58089"/>
        <property type="gene ID" value="Ngar_c11480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1088"/>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="OMA" id="MLYADYV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1146-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="119"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="235"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="468" mass="50034" checksum="63B623BF0434540F" modified="2012-11-28" version="1">MPSDGHNIIDSLRSLISSSKGASYVEARYQARVTTEVNFVNGELERIRVVENAGCGIRVLVDGCWGFSSTNNISLLKESLDQAISAARVLAQTKKNKVQGLAKSKMITGTFRAPANVSLSDVDIEQKVKVAREGEKAARSNNKVVKAASCTYREMLDHKAIVNSDGADVEIYDSKPEFSVVAIAKRGGQSATAHEGVGITGGWNDLFKKSHLEYAAAASERAAKLLDAKHVNGSKATVILDPAMVGLLSHEAIGHTVEADFVLSGSVVKDKIGEQVASNLVTLVDSGRSEIVGNAGGTIIIDDEGVAAGRTAIIEKGILKSFLHNRESAMTFDTESTGNARAFQYNDEPLIRMRNTFIEPGTDKLADMIKETKHGYIVKGARNGQADANGEFMFGAEEVYLIENGEVKELMKGASISGNAFHVLKSVDMVGDEFQYDIGTGYCGKYQLAKVDGGGPHIRCTAVIGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR4</accession>
    <name>K0IMR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58124">
        <property type="protein sequence ID" value="AFU58124"/>
        <property type="gene ID" value="Ngar_c11840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11840"/>
    <dbReference type="HOGENOM" id="CLU_2257455_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1182-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="12249" checksum="DD284346D7F118AD" modified="2012-11-28" version="1">MTKVKSGDTMQLRYALNESECTACSSHLEWQLDLKDINRPRYVSYHCNYQYVIYIDNVKVDVKRVDRKKQESLENKPVKDDEPRAILIAQTKKKERQRQEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR9</accession>
    <name>K0IMR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58134">
        <property type="protein sequence ID" value="AFU58134"/>
        <property type="gene ID" value="Ngar_c11940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11940"/>
    <dbReference type="HOGENOM" id="CLU_2091376_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1192-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="12827" checksum="46D0C2D63442A0DD" modified="2012-11-28" version="1">MSSTAVQAEASKPQKKMQECNRCKAAGFPNQPIAFEKVGEDPATGKIKWKLVDENGNEHVHKGTSAFASRRKRIVDIATVSDVGEARKLLALGWEYKTSYPATIANVPHYVLVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU9</accession>
    <name>K0IMU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13160"/>
    <dbReference type="EnsemblBacteria" id="AFU58254">
        <property type="protein sequence ID" value="AFU58254"/>
        <property type="gene ID" value="Ngar_c13160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13160"/>
    <dbReference type="HOGENOM" id="CLU_095977_0_0_2"/>
    <dbReference type="OMA" id="CEPVNPG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1314-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="17832" checksum="961EBF80EC99745B" modified="2012-11-28" version="1">MIEVYFDGLCQPINPGGIACYAFVVKSNGKTLHRDYGVAGEPFSKDSTNNIAEYTALAKALEWLVANNLAFDKVEIHSDSQLVVNQLEGNYKVKAKRIVPLYRKVLLLKAKFPDMKIKWVPREQNREADRLTNIAYNKTLRENPEYLNRVLKEEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN31</accession>
    <name>K0IN31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl4p</name>
        <name evidence="4" type="ordered locus">Ngar_c17310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17310"/>
    <dbReference type="EnsemblBacteria" id="AFU58664">
        <property type="protein sequence ID" value="AFU58664"/>
        <property type="gene ID" value="Ngar_c17310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17310"/>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_2"/>
    <dbReference type="OMA" id="WHQKVNV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="270" mass="29197" checksum="3B6D533DDFE8EBEC" modified="2012-11-28" version="1">MKAKVVAVSGKETGEIELPVVFDTPYRPEVIHKVYVNLLSHSYQRQGRYPAAGEMVSAESRNTGLGIARLARARGEGFPRAGQAAGVAGVRHGRVAHPPESWKIIYKKINHKEKQLGLCSAIAATTRKELVQQRGHKIGDNVKLPIIVSNDIESIAKTKDLKKALLDLGLGDDIARASMTRKAQSGTARRRGRPARSGTSALIVVGNNSKLVALSRSISGVDIKHAKDVSVIDLAPGSKPIRLTIFSQSAIDELKSLQAPMHKVMELINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN34</accession>
    <name>K0IN34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein, ArsR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58679">
        <property type="protein sequence ID" value="AFU58679"/>
        <property type="gene ID" value="Ngar_c17460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17460"/>
    <dbReference type="HOGENOM" id="CLU_1718128_0_0_2"/>
    <dbReference type="OMA" id="SMKHRDP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1744-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="19565" checksum="D10B7AA6F4F6578E" modified="2012-11-28" version="1">MRGVAICFIVKSYIGDSAALTKDIETPPPDDSSKKLPIEDQLKGKTLQVYMYMIKKKEPVGVREVQRDLGFSSPSVANYHIDKLVEMTLISQDEYGRYYVVQKVQVGVLQAFVNIGGLTVPRLSFFAAFFTTVLIAYVVLNLENLDIYAIGFALAGTVAFWFETIRVWIKRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN99</accession>
    <name>K0IN99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative THUMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20730"/>
    <dbReference type="EnsemblBacteria" id="AFU59004">
        <property type="protein sequence ID" value="AFU59004"/>
        <property type="gene ID" value="Ngar_c20730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20730"/>
    <dbReference type="HOGENOM" id="CLU_097042_0_0_2"/>
    <dbReference type="OMA" id="TGWRQER"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2071-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="PTHR13452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="19468" checksum="882AF5E5912A76B7" modified="2012-11-28" version="1">MANFNLIVSTSRFSEEEAQDEILDLLDMFGDPDAESEITEIKGLLLAQTALDPFEVIEKLKELIASEPWEVRYILRVLPVERVVPTELDAIRQAARDLAVAKIGNNESFRITVEKRHSALESIEVIKAIAGEIESKVDLENPSWIVLVEIIGGEAGLSVLRPEQIFSSVIEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF3</accession>
    <name>K0INF3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative deoxyribonuclease/rho motif-related TRAM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23490"/>
    <dbReference type="EnsemblBacteria" id="AFU59274">
        <property type="protein sequence ID" value="AFU59274"/>
        <property type="gene ID" value="Ngar_c23490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2323"/>
    <dbReference type="HOGENOM" id="CLU_154338_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2347-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="14147" checksum="88C4EA8444D56938" modified="2012-11-28" version="1">MEDSSSYGGSDSGGYRGGSGGSRRFGGNRFGGPRPFRPSPVRVGEEYDVKIESMSKRGDSGVARVQGLVIFVAGTKVGDSVKIRITKVGRGYATAEVAGQAALAGEAASEAPAAAEEPEGGVESETEEEAEEEKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM3</accession>
    <name>K0INM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59624">
        <property type="protein sequence ID" value="AFU59624"/>
        <property type="gene ID" value="Ngar_c27030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27030"/>
    <dbReference type="HOGENOM" id="CLU_2519879_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2703-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="8898" checksum="ACF64AA253CB386B" modified="2012-11-28" version="1">MDEAGAAAKVAVMANTGIESRLGRNIPIGMPVGANKPVRFAKEKEVMFALGIPEMENPVPAGVIEMTNGQRVPVSFDISYILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN9</accession>
    <name>K0INN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59704">
        <property type="protein sequence ID" value="AFU59704"/>
        <property type="gene ID" value="Ngar_c27830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27830"/>
    <dbReference type="HOGENOM" id="CLU_2893371_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2783-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="7340" checksum="D3CF0D115FF695EE" modified="2012-11-28" version="1">MNAMHTDTINLVRLKQLAIKYLDQDSAFRHLLLAEPDEVPFQEGVIKLMVYSRLFEFELKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP0</accession>
    <name>K0INP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59709">
        <property type="protein sequence ID" value="AFU59709"/>
        <property type="gene ID" value="Ngar_c27880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27880"/>
    <dbReference type="HOGENOM" id="CLU_1060141_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2788-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="262" mass="30595" checksum="1FC04575CECEF97C" modified="2012-11-28" version="1">MTRQKQTLGPDYNEIEQAIADMLKENTGMHFLDSGGAYGRHWQRNQAIADFRQLPELSIEIWDDRDFCISLDVFHYLTSFLELDGLAKDLQKQFDDYSELPDNKDKGWYELMQTFAEDILRDQYGYRIEESFNTYNYENLLGQVLQGLTFHVADIDYPDYIILQIHGGCDVRGGYTKPRIFKVPEFDYFTIVQFDLYASCKCTNCSSDDSGYHWYIDGSTADKSHEYKFPSYWIKSGTKNPSNSLKCTRCKSKVYFTPCLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ0</accession>
    <name>K0INQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59759">
        <property type="protein sequence ID" value="AFU59759"/>
        <property type="gene ID" value="Ngar_c28390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28390"/>
    <dbReference type="HOGENOM" id="CLU_117038_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2839-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="180" mass="18914" checksum="8AAE46EA02D4DBD7" modified="2012-11-28" version="1">MTARETVKKTGVWSSRFIIAAIVQGAVVMGLTISIVVAQMLVSNINIIQFLSLSFEGPAKWFFLGYILYLILVIAIAVTAVFYNHLEANLGKGIHGFRSVLAWVHLIGMNAGGAAATIGMIFAGLAGSGMLDVVAGGEELRPNPAIMDQFIVPIATSAGLLSIGVLAGGLAYISTYLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR4</accession>
    <name>K0INR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59829">
        <property type="protein sequence ID" value="AFU59829"/>
        <property type="gene ID" value="Ngar_c29100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29100"/>
    <dbReference type="HOGENOM" id="CLU_782157_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2910-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="354" mass="40468" checksum="8E446AB5EDF31D66" modified="2012-11-28" version="1">MSKIQIFRFLFQADPKIMNIQSYKQIAEKKGWRAHLTGPLVSMVERDILTFDTFSILATMANDELSFGGGTLLNWIQLCDSPRFSFDVDTQLQFPARTKQEVMTKIIEPINDSLRKSGKVTPIEINGKKFEVGLIYFDREKDHFPNMLSLKRSVHALTIGRDAHEYLRKEMNGLTDKEVMKLKSMYGGKFGKIEDVRIEIGFSESGDPKFPSKATVVEPLVNPEAGLTPVEAKVTVIEHTIASKIFRLGKRYTDAELEFAIPEFIKAISDLRYWESANLDEILEYIRQISASENYSVMEILDSSDNMLDWLKSERKAKDQFERGAQTSMLATKIGYLELINNSSELVQKIRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS7</accession>
    <name>K0INS7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c29760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29760"/>
    <dbReference type="EnsemblBacteria" id="AFU59894">
        <property type="protein sequence ID" value="AFU59894"/>
        <property type="gene ID" value="Ngar_c29760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29760"/>
    <dbReference type="HOGENOM" id="CLU_135915_1_1_2"/>
    <dbReference type="OMA" id="YDKMARR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2976-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9704" checksum="BB4A7FF1CCD9203A" modified="2012-11-28" version="1">MISMIGVAAAALTTSSFLPQIVRAYRTKSMGDVSRYLMSMFATGTVLWMVYGIFKEDLVIIGANATATAFNIILLYMKVVYKAKPAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP39</accession>
    <name>K0IP39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60454">
        <property type="protein sequence ID" value="AFU60454"/>
        <property type="gene ID" value="Ngar_c35410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35410"/>
    <dbReference type="HOGENOM" id="CLU_3094239_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3542-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="6202" checksum="E76EAE2E6B9C4CEB" modified="2012-11-28" version="1">MLLTFRLLNNTLERDRSIADNKLTEPIQHEKWIIISSNIFYLLVPKEQFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP51</accession>
    <name>K0IP51_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c36010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60514">
        <property type="protein sequence ID" value="AFU60514"/>
        <property type="gene ID" value="Ngar_c36010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c36010"/>
    <dbReference type="HOGENOM" id="CLU_127454_0_0_2"/>
    <dbReference type="OMA" id="EDEYNAP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3602-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="19862" checksum="628D42413AEAA5E5" modified="2012-11-28" version="1">MFVINIGRAGVKCYHVNRSSYLFGMISGKRKFRIELEDAEGSKYNLSLEGNVSKEKIMKIVEFMDLLNIESNGNNNSEGETLTRAPGSVGDRIWSLVESKFPYGSFTSTDILELYEDQYNEPIKLSIISTYLSRYSERGRLVRTRQGKEWVYRTATTRQQQAQPSPSASLDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0I798</accession>
    <name>K0I798_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA/ propionyl-CoA carboxylase, carboxyltransferase subunit</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accB</name>
        <name evidence="4" type="ordered locus">Ngar_c01870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01870"/>
    <dbReference type="EnsemblBacteria" id="AFU57136">
        <property type="protein sequence ID" value="AFU57136"/>
        <property type="gene ID" value="Ngar_c01870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.187"/>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_2"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="260"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="513" mass="56014" checksum="937C80BAE276141F" modified="2012-11-28" version="1">MHEEKIKRLATMKKSAESGGGNERIEAQHSKGKLTARERIALLLDEGTFVELDKYVTHRSDDPTLPKFYGDGAVTGFGTIAGRQVFVFSYDFTVLGGSLGEMTGKKIAKAMDHAMKVGCPIIGIIDSGGARIQEGVMSLDGYGDIFFRNTVASGVIPQITASIGPCAGGAVYSPAMTDFVIMVENIGQMFVTGPEVVKEVLSQEVSFEELGGARAHATKSGVAHFIAKNEYECFDKIKKLLSFLPQNNTEEPAMVETNDDPNRIDADLINKLPENPYQQYDMKEIIKSIVDNGDFFEVHELWAENILVGFARMGGRSVGIVANQPQYLAGALDINSSNKAARFIRFCDAFNIPIVTLVDTPGYLPGTDQEHNGIIRNGSKLLFAYCEATVPKVTCIIGKAYGGAYIAMGSKNLRADINYAWPSAEIAVLGPEAAVTIIHRRELKNAPNAAETKKKLAKEYRDKFANPYIAAEKGIIDVVIDPMETRPMIIQALNALANKKEARPWKKHGNINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7U8</accession>
    <name>K0I7U8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cell division control protein 6 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03930"/>
    <dbReference type="EnsemblBacteria" id="AFU57341">
        <property type="protein sequence ID" value="AFU57341"/>
        <property type="gene ID" value="Ngar_c03930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03930"/>
    <dbReference type="HOGENOM" id="CLU_2271123_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-393-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11184" checksum="B8A8C2081343D6D9" modified="2012-11-28" version="1">MKELVGFLVTYKQGFVVPFISVYGRSGSGKSTIVKFVCENLDGVSHCFVNLRKARTVFGCANLILAELGEPNLKSAQGINLTVEKIQNAIISTWQLATINYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8H3</accession>
    <name>K0I8H3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cupin 2, conserved barrel domain protein</fullName>
            <ecNumber evidence="2">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06330"/>
    <dbReference type="EnsemblBacteria" id="AFU57576">
        <property type="protein sequence ID" value="AFU57576"/>
        <property type="gene ID" value="Ngar_c06330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06330"/>
    <dbReference type="HOGENOM" id="CLU_1923882_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-631-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14383" checksum="7689AB1F68F33E76" modified="2012-11-28" version="1">MVIVVRNWRNVHPTIAHKSGLDWRLLGMPAKTSGDIEVEVDPKFQCLKTITYVSLAKLQPTLSYEPHDHQDHEEVYYIISGSGQIKVGGESARFRDGDVIYIPEKAVHSITNDGSEMIEFLAFGGLTGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8J6</accession>
    <name>K0I8J6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57606">
        <property type="protein sequence ID" value="AFU57606"/>
        <property type="gene ID" value="Ngar_c06630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06630"/>
    <dbReference type="HOGENOM" id="CLU_1521915_0_0_2"/>
    <dbReference type="OMA" id="HANPGAI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-661-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="20458" checksum="883A87476EC000A6" modified="2012-11-28" version="1">MDLLLTESGIAYSVHSYHANPGAIIAYVQFRGPLNHPNRIKLDISLSEKMALKPESRMIKSDFADLPDFKILAYSLKEIMSEKIRSIMQRGYSRDYYDVWRLLKENEFDKQEIKDLLVKKCKLKGIPYEPGLLFDKTRLEEARAHWSRGLSHLVKELPDFDEVISELKAGLLFLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8X0</accession>
    <name>K0I8X0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57696">
        <property type="protein sequence ID" value="AFU57696"/>
        <property type="gene ID" value="Ngar_c07530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07530"/>
    <dbReference type="HOGENOM" id="CLU_188388_0_0_2"/>
    <dbReference type="OMA" id="IYKMEGC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-751-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018592">
        <property type="entry name" value="DUF2024"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023122">
        <property type="entry name" value="NE1680-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09630">
        <property type="entry name" value="DUF2024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160766">
        <property type="entry name" value="SSF160766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9971" checksum="82692311199890E9" modified="2012-11-28" version="1">MECAVYDTYVTKKDGKIMHFDVVVQDGTPHEKAIEYGKKYLESVGQGGQKITQEECQFCHIQEAPPFVEKAIRQNGYWIQKMEGCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I920</accession>
    <name>K0I920_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57791">
        <property type="protein sequence ID" value="AFU57791"/>
        <property type="gene ID" value="Ngar_c08490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08490"/>
    <dbReference type="HOGENOM" id="CLU_119856_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-847-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="19845" checksum="36EFBBCA31994A31" modified="2012-11-28" version="1">MAGRSKLSDIKETASDAVEIMRELGTPGVQETFDKIREVAITAKEIMETMKTPEWQRNMENIRMISENFNQASERMDNTMKELKETGVIDDAKELIKTAKEKVGSFGGSGEGGGSMGMQDLKEMSKAVKEMLESIKGLVDELKVTVAESKRSGTFRSVEETARELSDTVKTVKRDIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9V3</accession>
    <name>K0I9V3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58111">
        <property type="protein sequence ID" value="AFU58111"/>
        <property type="gene ID" value="Ngar_c11710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11710"/>
    <dbReference type="HOGENOM" id="CLU_631089_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1169-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="434" mass="47480" checksum="E23E680C4FE18F79" modified="2012-11-28" version="1">MNFYALRGTVTDTDITWNSPVLLGYTFANSDACGSGGACAAAVAATDTDANIYAAFRYRSGGSSTYSYQIMKSTDGGLNWSVSLSQVDNVSNNRIVMALAPLTSGKMLFAYALYESPNLQYRVFDGTSWGSVQTASSTNMGTNTIKQISADSINSTKTAYVAYLSSGNSGSLYVARFANTTGAFEGNETATTSGSHQLPSITISFDDIIHIYTVSSGKLYETRKNASGWQAPVTPYGDTFYSINELTSQISGFESEGVFWREGSSAPYTLKYDGRFFGIGGVICWQYISNSQHCSDSKRLGSGTVKVETPDPQRSYWVKKKACGWVFKVKCVNTSVFVQYPSTFTEGGRTYNFVSGYVVVTAAHPLVYQQSKFWTGGNSKIFKFYDVPRESLLGWDMQVTVSTILVYESSCGCRISGKLYTHVMILYKGYDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA60</accession>
    <name>K0IA60_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HB_MCP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58191">
        <property type="protein sequence ID" value="AFU58191"/>
        <property type="gene ID" value="Ngar_c12510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12510"/>
    <dbReference type="HOGENOM" id="CLU_2044486_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1249-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="4HB_MCP_1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13635" checksum="F40206907D4A9F5C" modified="2012-11-28" version="1">MKLVIKLFSVFLTIAVLIIIAGYLGYNQVTNSSAFSKVESDDMPALWALGDIEAAILRIELEPSEYIVKSDKEHSEELQEAKEEILAALEVYGNGGVKKRQARWHRKWKSSSRWAKKYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAF6</accession>
    <name>K0IAF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58296">
        <property type="protein sequence ID" value="AFU58296"/>
        <property type="gene ID" value="Ngar_c13580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13580"/>
    <dbReference type="HOGENOM" id="CLU_1485938_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1356-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="181" mass="20385" checksum="4EAA7E9E92212C3C" modified="2012-11-28" version="1">MVRFKSAAESKAESEGKTVTLKEFQSIMAKKGNKGVKERREIISVYRYFDEGREKEFFYYHEQRSADTNTDGWISAYTSHVGFSEEFPPSEEFEWTPANLANIKKYFTTGTNFYAYIGDRRTAINRHDFETARLADIENRIATVRIDAQSLISAVNNVATAAAATTTTTAKKSTTTTSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBH8</accession>
    <name>K0IBH8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58631">
        <property type="protein sequence ID" value="AFU58631"/>
        <property type="gene ID" value="Ngar_c16980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16980"/>
    <dbReference type="HOGENOM" id="CLU_898982_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1696-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="309" mass="37064" checksum="DB85B2F5C9D9BA64" modified="2012-11-28" version="1">MHLFRYIAELERKGVLQKRLAFDIRPSDKDFFRHLTEYALNNEIFYAREIERYLKRKRSKEEMIHYVQKRKAMKHPHVNKHFKELANAGLIVKVEDKLLPHARARPFKISPLGWLYFWAMLRIPFRSYFEILKERYDSDPIVEAFIQPYFEKKTVQSLIHSTYVIDEYLSPGSFQPYLEKCCRDLISDLQSIRFSEEFFKARVRYRAKMFILEEILFMGREPVSFSILGKWKDKNLERYQVRSEIEAIRSLGHKKGSLLRQDRKFMTVLGEIRDELGRAMLYFVDSQKKNKKDDVSYLLAPELAKVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBQ3</accession>
    <name>K0IBQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Na+(Li+)/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c00500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57000">
        <property type="protein sequence ID" value="AFU57000"/>
        <property type="gene ID" value="Ngar_c00500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00500"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.57"/>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-50-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="16"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="413" mass="43485" checksum="CD2D056A94BB3D11" modified="2012-11-28" version="1">MAAEAAFLHVMISLGILLFAAKMMAELFHRVKLPIVLGELLAGIIVGPFALGALPLINGEPLVVLDETVRHIGEIAAIVILFIAGLEITPREFLRGGAAAFTVGSLGVIVPFFVGYYAFSAFGVEALQSILIATALTATSIAISIQVLTELGKMQSKEARLILGAAIVDDILAIAALSVVVTMVQTGNTEPAILDITLLIMQVLGTFAAILIVSVLVIPRMLHTERLWKSRGSMEGIVTAAFFAAAGIAAFVGLSPIVGAFAIGMAVASTRVIKQVHEYVDKLQIIFAPLFFAIIGAQVDLRGVNPNVLYLAGIMIAVAIVTKLVGTGLPSIIFLKDKARAMRVGVGMISRGEVGLIVAGVGVSSGALSNDIYTTVIIMVAATTIITPIWLKFAYRNESVEHASPPKTKHQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICL5</accession>
    <name>K0ICL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YVTN beta-propeller repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57365">
        <property type="protein sequence ID" value="AFU57365"/>
        <property type="gene ID" value="Ngar_c04180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04180"/>
    <dbReference type="HOGENOM" id="CLU_1544247_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-417-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="18971" checksum="E265C17988A54F5A" modified="2012-11-28" version="1">MLVIKDNEIKEEIQVGSGPEYTEVSPDGRYLYVANLWSPIPVVDLRNKTAIKEIDSGETPHGLSFTDDELRLFIVNMESDILSVIDVTKHEIIKTIPVGDRPEYVALTPDERFAFVTNLGAGTVSVVDADSLEVVKEIQGVGDGSHGIAFSADGDLAYISNMFQTILPSLYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICP6</accession>
    <name>K0ICP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59141">
        <property type="protein sequence ID" value="AFU59141"/>
        <property type="gene ID" value="Ngar_c22110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22110"/>
    <dbReference type="HOGENOM" id="CLU_2802397_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2209-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7340" checksum="2BD697B8E528A639" modified="2012-11-28" version="1">MSDPVAQLAELPAKNCKVQKVQPAVFASDAEVNIITVTVVCPDGATHKIRAYREQAQAVREFVRTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICY3</accession>
    <name>K0ICY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation initiation factor 2, subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eif2g</name>
        <name evidence="8" type="ordered locus">Ngar_c05820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05820"/>
    <dbReference type="EnsemblBacteria" id="AFU57525">
        <property type="protein sequence ID" value="AFU57525"/>
        <property type="gene ID" value="Ngar_c05820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05820"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.556"/>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_2"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="420" mass="45266" checksum="6BB45CBCFD0FE767" modified="2012-11-28" version="1">MHWKETLPDWYIKEYGYQPCVNIGTSGHVDHGKTTLIEAITGVWTSAHSEELRRGITIKVGYADAAFYKCPKCPTPEAYGTQPKCNNCGGKSELQRVVSFVDSPGHESLMANMLSGAALMDGAILVVAANEKVPQPQTREHLLALSVLGIQQIVLVQNKADLAEYDEALDNYKQIKDFVKGSVAEKAPIIPVSAQHKLNIDALIEAIENNIKTPARTKNVEPIMHVLRSFDVNKPGTSIKQVKGGIIGGALVQGEFNVGDEIEVRPGLLDEKKGKYEPITSQISTLGTGAGLVDAVKPGGLVAIGTKLDPTFTKSDSLIGSLVGKPGMLPKAVEDITVETHLFDTAVGTAEMVKVEPIKVREPIRLNIGTAASVGTVTNVRDSKIEVKLKKPVCLMPKSRVALSRRIAERWRLIGSGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID40</accession>
    <name>K0ID40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59301">
        <property type="protein sequence ID" value="AFU59301"/>
        <property type="gene ID" value="Ngar_c23760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23760"/>
    <dbReference type="HOGENOM" id="CLU_1840646_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2374-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="16857" checksum="F7D9231406681DE0" modified="2012-11-28" version="1">MQNRSVISRRRYVAAKEQQLLTLGDIAPSWDERLKQLPVSKWSLKWLKWYFDIASRETCIVGEAFGQSSAYWNECAECRTFSRQFPRHYKALSYKELERDVQRFVGHWNEKHRDVENNRRCLRWFDSFVRSDGYIRTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDI1</accession>
    <name>K0IDI1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59461">
        <property type="protein sequence ID" value="AFU59461"/>
        <property type="gene ID" value="Ngar_c25390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25390"/>
    <dbReference type="HOGENOM" id="CLU_177467_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2538-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9422" checksum="059B2F26D71EB1FB" modified="2012-11-28" version="1">MTKMLNVNIDTSGIDANEAKEWVNELANVYADMQISDVNVSGNKISFKAGFSGMDDTEPDDVKMKIEEYLTMNETFHAKSINVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDI5</accession>
    <name>K0IDI5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57715">
        <property type="protein sequence ID" value="AFU57715"/>
        <property type="gene ID" value="Ngar_c07730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07730"/>
    <dbReference type="HOGENOM" id="CLU_2217134_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-771-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="11688" checksum="8FC20210E22A74DA" modified="2012-11-28" version="1">MSTDVLLTNKSSSGIIYELKEKAKWSDDRQEKKTAIKQLSAYGSDALSALEEVFNVTAYDEIRVACVDAINTIKRAASKTEAAAETQTTTETTLTKSESMKEARNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV0</accession>
    <name>K0IDV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57915">
        <property type="protein sequence ID" value="AFU57915"/>
        <property type="gene ID" value="Ngar_c09730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09730"/>
    <dbReference type="HOGENOM" id="CLU_3130971_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-971-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5770" checksum="BA9A524F84AD95FA" modified="2012-11-28" version="1">MSGTATGQSIKENWDTELWQIEEGKFYTSRKIEFKPTGDSEPSLYIWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDY7</accession>
    <name>K0IDY7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57970">
        <property type="protein sequence ID" value="AFU57970"/>
        <property type="gene ID" value="Ngar_c10280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10280"/>
    <dbReference type="HOGENOM" id="CLU_1514664_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1026-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="177" mass="20210" checksum="A65806BF32F0DD38" modified="2012-11-28" version="1">MRYYHSVAIAALVIAIVFIQPAYSDDEPGVVILLYPPTDCKTDFDQDFWAKYDSAMAQEWGISSQTICLDQLNEQEKADLQTALHRVGLNVIVMQDNNQIIHGINDRAQGVAQPTVNFGAVEFNYEYSAKVVSHETLHLMLEERGYPKSCYVDAVHEHAYTLARYYDNIMIIQHFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE76</accession>
    <name>K0IE76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59661">
        <property type="protein sequence ID" value="AFU59661"/>
        <property type="gene ID" value="Ngar_c27400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27400"/>
    <dbReference type="HOGENOM" id="CLU_1431869_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2740-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021617">
        <property type="entry name" value="DUF3231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11553">
        <property type="entry name" value="DUF3231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="22007" checksum="58C5B957E70FE58C" modified="2012-11-28" version="1">MKNTAYAEERYRKHYADRDSLSSSEFTVVMEGLLREYVCMGQCNMYIAVAKDSEIKQAIKTYLMDVCNQNFMSMKKILQDGGYDVPVSEQNATSPDKVHDVQINAIDDQMIVVGQWFAARSFMQLWDMGAINSQRTDIRDAFIQNFHRANRWHVAFHDLAVSKGHLQKLPEISPTMTKMSKAGQKLKESLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEC5</accession>
    <name>K0IEC5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c27550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59676">
        <property type="protein sequence ID" value="AFU59676"/>
        <property type="gene ID" value="Ngar_c27550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27550"/>
    <dbReference type="HOGENOM" id="CLU_032903_9_1_2"/>
    <dbReference type="OMA" id="INIECEG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2755-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="26421" checksum="A8B8E6FEC6CCEB84" modified="2012-11-28" version="1">MTTDDNVEKSIKIDVTKSVGIDVGLINWLALSDGRMIENPLDFDAQAKKIKKLQRNLSRKEKGSHNREKARVALAKAWRQVRRCRDDFVHKTSKMLVDEGYTLVVFEKLNIVNMVKNHNLASAIMDATWGKLRQLTAYKVERRGGRCITVNPSGTSQKCSGCGVETKEKLDLSIRTFECHSCGLVLDRDMNAAKNILKSGLEQARAETEPLLIRQRISKFQSRKQEAHVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IET2</accession>
    <name>K0IET2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c13320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58270">
        <property type="protein sequence ID" value="AFU58270"/>
        <property type="gene ID" value="Ngar_c13320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13320"/>
    <dbReference type="HOGENOM" id="CLU_1259133_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1330-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="219" mass="23600" checksum="B1130862B62E5AD2" modified="2012-11-28" version="1">MAGSKNSSGGPKESDNGDKSLRGLIIALAVVGTIAGSVILLAYASSESPAPDEAASIVDEVALQPEEMPVIVEEIVDELAFTEKIEYINSTAEVKEEPSGVNNTTAEVEKEIPRAEQEQPAYDVNNTNDISGNLTGNDPDSEEESSDDLPSSDQSAEDNSQAPPTEPNEQENEDQDSSDETDKRELQDILPKRVLDLLDRVIDVDDDDKNKGKDRKGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEZ3</accession>
    <name>K0IEZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disulfide bond oxidoreductase D family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04210"/>
    <dbReference type="EnsemblBacteria" id="AFU57368">
        <property type="protein sequence ID" value="AFU57368"/>
        <property type="gene ID" value="Ngar_c04210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.402"/>
    <dbReference type="HOGENOM" id="CLU_838376_0_0_2"/>
    <dbReference type="OMA" id="KSFFMGL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-420-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="48"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="344" mass="37100" checksum="38DAD15E8F37A1F1" modified="2012-11-28" version="1">MQQKNLTPEQAKVRTAIIIVLFVLFSAIVLSLFSIFLGGFSPSLALSYAAGISMIFLPCTLPLVFIIVPLAMGKEPKKGMAMAGLFGLGLTITIGIYGIAIGAAGQYIGMNNVIRIAFLVAGAAALVFAWSELRVIKFSMPDIGVRIPEGIQKRGDYIKSFFMGLLLGNAGVGCPNPAFYVLIAYIASLGSLSAGAALGLIHGLGRATPLIFIALLAILGVNPTQAIVKRKVSINRWMGWGLLLVGGIIFNYGVFGMAWWESSIIHFGWNELVRAILGENVAEQESLEELVAEAAPPTDNPWLLYGPWVLLGAIVAATQFVVYKRRTWGESMETHKDQQKEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF60</accession>
    <name>K0IF60_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carbamoyl-phosphate synthase, large chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14900"/>
    <dbReference type="EnsemblBacteria" id="AFU58425">
        <property type="protein sequence ID" value="AFU58425"/>
        <property type="gene ID" value="Ngar_c14900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1454"/>
    <dbReference type="HOGENOM" id="CLU_052967_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1488-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="120"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="331" mass="37231" checksum="9230FC66D3E73F6F" modified="2012-11-28" version="1">MERSIRTVVVPGAASPAGINTIKALRMAGFKGRILATDSCHLAAGFFIATSYEVMPRVNDEKNYANRLFDLVSKHKVEVLMPSSGYDIYPYSKYRRQLEEMGAKAVVSDLESLETCYDRVLTFRSLSEKFSCILPLTTTDPYEIKEFPIFAKPRREKGGHYAARIDDQNDLNYFISKFKNENKRGDIIFQEYLPGTEYTIDVLCDLEKNPLIAVPRIRLETTAGISTRGQVMRNPEIEQTCMSIAEHIGIRGPCCIQMKESSEGTMKVTEINPRMGGGTIFAALAGANFPDMILKMVEGKAVAIPKISEITVVRYFEEIIVQGRKQLMPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFN6</accession>
    <name>K0IFN6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupredoxin containing protein with WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07000"/>
    <dbReference type="EnsemblBacteria" id="AFU57643">
        <property type="protein sequence ID" value="AFU57643"/>
        <property type="gene ID" value="Ngar_c07000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07000"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.675"/>
    <dbReference type="HOGENOM" id="CLU_013721_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-698-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="613" mass="65618" checksum="550316A3C8F58FE0" modified="2012-11-28" version="1">MIFIAPLSITNSFQMALAASGSGSSGSSSENRVQFDLVDEPGRWFKNVAGDITNSGTQSLAVGTPGVRVDFNIRSNTVHTVTSLIFPQNAQGMPFDQPKASKSSQSVTLQTPGLYVFTCKVHPYMFGAVIVDDPQTQGLDLGENISLVNGITVPTSSDLATRLLRTFFIATAPSNWQDYRQSTWHVTYPNVDIRIAGGAVVNLPTVLNARYGNDIALEAPFDPSTAGVGKVWVDTQFELTKNKSKPGTATKIDTTTWDIERKVALPSINMNNPHNMWTDRDQKLIYQTQWFDSKLTVFDAATGKLVKNISVGESPAHVMTRTDTDQVHVTLNGEEAVVELAPKATGIQREIPMQKEGEPESHPHAHWMSSDGQKMVTPNAFSADSTLYSFDSDSIEAKPTTGAIPIATGMMPDDSKYYVANLLDSTISVIDMDENSTTFGQVIKTINLIENYDPISGAITGPVGALPIQTPVSPNGKYMVTANTLTATITIVDTATDEVVTMLGCDAGCHGVQFGAKNGGGYYAYVASKFSNSLLVVDADPNNDGNVSDAKIAGRILLTASSTTAKDDTITGNAGMGGQGVLATPIPYNGWVQNLPATLKSQLTSEQQNPIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG18</accession>
    <name>K0IG18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c34360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34360"/>
    <dbReference type="EnsemblBacteria" id="AFU60351">
        <property type="protein sequence ID" value="AFU60351"/>
        <property type="gene ID" value="Ngar_c34360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34360"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3434"/>
    <dbReference type="HOGENOM" id="CLU_048986_0_1_2"/>
    <dbReference type="OMA" id="YSKFFLG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3437-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="390" mass="41858" checksum="37C8AD84BDE316E9" modified="2012-11-28" version="1">MPHSDFDKSSPAGAKSTSPSREAAHSKILVLCIDRDDDIGSKGGIETPIVGRDACINAGTRLAIEDPEDADSNAIFGAVKTYEELVSKGYTAEVAVVAGKFNRGVEADEKISLEVKSILEKYHADGAVIVSDGEDDETVLPIIQSRVPVISVQRVIIRHSRSVEYSYAVLGRYLKMLVYDSQYSKFFLGVPGVLLAAGALAVIFDAGKWITAIILAILGGAFIVRAFDIDKTLSSFGRLTPTSFIKIFSVIAGVLIILASFANGLSSIPMDMLRPDMSALDILSNRTIVGSFATGTITLLWIGIATILGGILLSNWFRGSTRTMSDILRLAVLALLYIPVLQFTAVLTEGTSPFTLISSLLIGLAVSLVAATFLYQYFRNKKGGSEVLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG35</accession>
    <name>K0IG35_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57773">
        <property type="protein sequence ID" value="AFU57773"/>
        <property type="gene ID" value="Ngar_c08310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08310"/>
    <dbReference type="HOGENOM" id="CLU_1478964_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-829-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="205" mass="22123" checksum="C6E1679491557A39" modified="2012-11-28" version="1">MQIESNKGSSLTAAKALAILVVGGSVLVSIGVVILGQMVGKGIESVMIIHDYYTVLAIMSGAGFIGVLIFGSTSMGQQVQRRLDSINVLKVLAFTAVASAFLIEITGTIGYIEYRLPTPDSAKSKILEIFPFAHAPMFEVMEYLGLVGTMWTGLVAYLTWHFKERMFTDAGVKNMMIILISLAIFYALYISLMGIVPTKIASVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG91</accession>
    <name>K0IG91_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35080"/>
    <dbReference type="EnsemblBacteria" id="AFU60421">
        <property type="protein sequence ID" value="AFU60421"/>
        <property type="gene ID" value="Ngar_c35080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35080"/>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_2"/>
    <dbReference type="OMA" id="ASTDHWR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3509-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="262" mass="29452" checksum="8B2C7CC00F28FCB4" modified="2012-11-28" version="1">MNYQYLQVDNLRLRYVDVGSGEPVFLIHGLGGSIKSWTNNIDHLAKSFRVIAVDLPGFGLSDKPKINYTIKFYKGFVVQFLKLLQLDQVSIVGSSLGGHIAAEVAINHPFLVRRLVLISPAGALPRSFKGSPALRKYVRVINAKSPQQVKRLLSAIDNKPVSDSYAQMVYQKFLMPGAKEAFLSSLAGSARAPRLTNRLNRIKAPMLLLWGKNDYMIPVKFAEPFVKMEKNCRIILIENCGHRPHFERPELFNKIVSDFLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGA4</accession>
    <name>K0IGA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58825">
        <property type="protein sequence ID" value="AFU58825"/>
        <property type="gene ID" value="Ngar_c18930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18930"/>
    <dbReference type="HOGENOM" id="CLU_2597865_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1891-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8943" checksum="BA56E4056D22E455" modified="2012-11-28" version="1">MLSKHEMAFLTGTLQLEGRAARNARHRIKKKLETLRQLGFNISYDGGKTSPLIETKTALFKVSICLQQARRQVPKNAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGL5</accession>
    <name>K0IGL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58955">
        <property type="protein sequence ID" value="AFU58955"/>
        <property type="gene ID" value="Ngar_c20230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20230"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_2"/>
    <dbReference type="OMA" id="IECDLIV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2021-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16182" checksum="60BF85BF9FE32505" modified="2012-11-28" version="1">MPSAILPKRILVPLDGSDPSFQAAKYAIKLAKMAKAEIIFMHAVVNPPYVEYKAAGLVIVRYIEEAKRHSEMWYKNLGELAAKEGVKASSETILDIASAADSIIKYAESKNVDLIVMGTHGRTGIKRFLIGSVANGVVTHAKCSVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGQ9</accession>
    <name>K0IGQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57007">
        <property type="protein sequence ID" value="AFU57007"/>
        <property type="gene ID" value="Ngar_c00570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00570"/>
    <dbReference type="HOGENOM" id="CLU_2839481_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-57-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7669" checksum="1DEF50A1819C7A40" modified="2012-11-28" version="1">MVVQMDILGPFYLRNSSTKNYIIVSCIDDCTRKVVSRWTERKRSTDVLDVLLQDWIYVPMGSQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGU0</accession>
    <name>K0IGU0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21290"/>
    <dbReference type="EnsemblBacteria" id="AFU59060">
        <property type="protein sequence ID" value="AFU59060"/>
        <property type="gene ID" value="Ngar_c21290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21290"/>
    <dbReference type="HOGENOM" id="CLU_1145252_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2127-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="26186" checksum="FB9D67CF9ED74912" modified="2012-11-28" version="1">MYFVNWQRKVSVEELNGQKVVVKRNKPTKEFHEFLLIYVYSLISMILIHPSAPPTFSEIMRNEGRDMRKQLEKIGISTPKLISISDIDLIEEYIEGGNLYVALASGQPAALAFGAGCLTGRLHKAGYAFVDNKAQNYLVRGDSVVRTDLGFIQKSSSHYARSMDIGSFLASVMDLGRYREIEKAFFDGYVSESGCKFSYLSIILRNIISLGFSSDSKMMFKNMVLDATMLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH84</accession>
    <name>K0IH84_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L39e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpl39e</name>
        <name evidence="5" type="ordered locus">Ngar_c12780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12780"/>
    <dbReference type="EnsemblBacteria" id="AFU58218">
        <property type="protein sequence ID" value="AFU58218"/>
        <property type="gene ID" value="Ngar_c12780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12780"/>
    <dbReference type="HOGENOM" id="CLU_2461864_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10481" checksum="67322F40FB402C5D" modified="2012-11-28" version="1">MLSVRFYTTTIRCQHTDASTITPTLKKRKKSILGSYMAARKNTSRKKRLLKRTRQNRPVPTWVVIRTNRKVRTNPKRRLWRRSDVNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH94</accession>
    <name>K0IH94_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23500"/>
    <dbReference type="EnsemblBacteria" id="AFU59275">
        <property type="protein sequence ID" value="AFU59275"/>
        <property type="gene ID" value="Ngar_c23500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23500"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2324"/>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2348-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="198"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="424"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="628" mass="69360" checksum="2607DE8A832A1551" modified="2012-11-28" version="1">MQRKSPYQESASQNIMAVILQSLPQESGLTKIEYEGPRIALYSKNPSYLMQNSQLVSNMVNTIKKRIVIRTDESIRKPQDESAKIISENIPKEAGVAGTLFDAVLGEAVVFAKKPWMLAQVGEDFDNIELAEKTGWKVRIRKAPQNMGLIEALYRTLGEAVGERTKFYREVGDKIFRDKLSESAEASLMTLGGFAEVGRSCMLLTTSESKVLLDCGLNIYAKDSLAAMPRFDAAGIGMEEIDAVVLSHAHMDHTGFLPALFKYGYSGPVYCTEPTLLLMSMLQRDYVRRSGNAALYSEKDIDSAVIHTITLTHGIVTDISPDVKLVLSNSGHILGSTSVHLHIGNGDHNLVYTGDMKFGRTLALENASWNFPRVETMIIESTYGGKEDIMCPREEAEARLASAISKTVSAGGHVLLPVPVIGISQEILLVLDRFMKGVQARVLVEKSISEATAVYEAYPEFLSKEVRQRVLESETSQFGSQFSIVESESLKNGSSEPAVILAPSSMLIGGPSVGYLKQIAGDPHNRLIMLSYQAVDTPGRIIQDGARQVTIKGEMINLQCQVERIDGFGSHSDYNQAMEYVKRLRPKLRRVLVNHGERQKAQNLASSINKFFKIQTQHPLVQEAIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF8</accession>
    <name>K0IHF8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57227">
        <property type="protein sequence ID" value="AFU57227"/>
        <property type="gene ID" value="Ngar_c02790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02790"/>
    <dbReference type="HOGENOM" id="CLU_851570_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-279-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="326" mass="35380" checksum="D3A2740F60CB0D9E" modified="2012-11-28" version="1">MKNRQAYALVLTGIICMGAIYAVPGQQAFAHEFSGDESASFLALIESIRVELGLVQSNFVSNVTLAEQHAEHAHKHLDEHTIKEISERNKRLGTALPAALEELHDSIGNSTTEQVQADIQEINNLLAETITVRISNEQLSNSTVWALVVANMADAVLEHYGAAYGMETEEGGGGHGHDEEESDNMTETTTTEDNNMTHGTREEAGGSMSMGEGNDAIVNVVHYQTSQGLAARTQVLFNEQVKNMAPANATQAVADLEAGLDHLIQAINNKELFADVEVIVHSEVHPNLQTAFNLQVIPEFPLPMLLIIPAIAGIIAATRFNALRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT8</accession>
    <name>K0IHT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57437">
        <property type="protein sequence ID" value="AFU57437"/>
        <property type="gene ID" value="Ngar_c04930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04930"/>
    <dbReference type="HOGENOM" id="CLU_2340267_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-491-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10995" checksum="F157C08C7AA8A666" modified="2012-11-28" version="1">MATIQQYKFKNGSAGLIETVYAIIRSKSGKVTSKDLDQMIGNKQDVRFAITRLTVQGRIKRVRGFGKVGIEYFYKDIASEPRKKPMEKVAATATTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU0</accession>
    <name>K0IHU0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58508">
        <property type="protein sequence ID" value="AFU58508"/>
        <property type="gene ID" value="Ngar_c15750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15750"/>
    <dbReference type="HOGENOM" id="CLU_1286376_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1573-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="23312" checksum="573F9EF76B4416E7" modified="2012-11-28" version="1">MVLGDYTIDSNVTLTSPNDSPTTNPSVRIVDNRSGSSLNSAPNIPSGNTINGVDIRGRNIGQVETYFMLDAISGATPIHGAGVYFRYIDANNWYCAGIHRRSDIVTKTWFVIVNNAGIKSEIATGNISQTINDATWYKMRITWWEATGQLFVRIEFSDNGGASWTQLNPGNTAHASNLHKSASNKIGWGAQNINLNGGAQSYAVQFDDFRVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0II09</accession>
    <name>K0II09_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57597">
        <property type="protein sequence ID" value="AFU57597"/>
        <property type="gene ID" value="Ngar_c06540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06540"/>
    <dbReference type="HOGENOM" id="CLU_2433957_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-652-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10567" checksum="FF5F5B492F3921D1" modified="2012-11-28" version="1">MQGLALLHPTDMVYFKMDSRNQLVDMRALSKNELKVLLEYYQRKLNRARQDDMKKAYNYCVQQISEFMYEGKASGPPDILSSRITQAIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II97</accession>
    <name>K0II97_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57712">
        <property type="protein sequence ID" value="AFU57712"/>
        <property type="gene ID" value="Ngar_c07700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07700"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-768-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="13836" checksum="859ED1D80A86D8EC" modified="2012-11-28" version="1">MDTKIRFAGIASLDGKILAAEYRQDIIIQKPLLTLQESELSMMQSLMRMSIRRTLEGKLGRTVYATAVYEKVKRATIPLFNEEEKNDSYLMVSFEREANHEAIINEKILPFLEKIGKGLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID9</accession>
    <name>K0IID9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58758">
        <property type="protein sequence ID" value="AFU58758"/>
        <property type="gene ID" value="Ngar_c18250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18250"/>
    <dbReference type="HOGENOM" id="CLU_2406454_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1823-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10068" checksum="65311C8700B4678F" modified="2012-11-28" version="1">MSSVLEDTDTLDCEDWDCEHVTIDPEDTDTLHFVDCEDLTTDTEDSPTTAVAETVKASGSRATAATNADVVTAATMKREFVIISLSDIMYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE5</accession>
    <name>K0IIE5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c08700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08700"/>
    <dbReference type="EnsemblBacteria" id="AFU57812">
        <property type="protein sequence ID" value="AFU57812"/>
        <property type="gene ID" value="Ngar_c08700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08700"/>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-868-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="361"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="579" mass="63812" checksum="1F8D2645B94CBC4E" modified="2012-11-28" version="1">MFIVILVALAAISGVSIFLTYTSLQSTEVRLSLAAAQELRSEIREHTNDAVADIGTELDTISKRIQTAASSPILLRGIDSEEARILLDATAVGMEEYVQSITYLDSNGVLLYTTEAELLDQIGSDRSDTMYYLQAKERNQPILAGPFLTENNRMSVSVLSPVFASSGSSFNGVLAAIIPIESIVDKIGQQLPPTTGKNQIFIVATDGTIIGYGDETAIGRNIFDEFRVRNEIAGRNLQLMIEGRSGVFEYDALDGQRRVAVYSPVTFSGAHTWSVLITAPASQSETFASVINDQRIFTIVAVILIGITSAILMIFILMINKRLQMIIQKQNVQIKNQLNELQDAYEKLTEQDKIKDEFINVAAHELRTPVLPIILSAEGLSEDIGTDNSKIEIILRNAKRINKLTNDILDVSRIKSNTFRLQKERTNVKKLIEEAIQDISFSKTAENKNPNLKIAFESQLPESKLEIVADRSRLHQVLANLLDNAVNFTDEGTITVSLQQNKDDPSFVEIRVADTGKGIDPSVRPRLFEKFVTKSTAKGTGLGLYLCKAIVEAHGGKIWAEDNSVGRGSVFVFTLPTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN2</accession>
    <name>K0IIN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58923">
        <property type="protein sequence ID" value="AFU58923"/>
        <property type="gene ID" value="Ngar_c19910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19910"/>
    <dbReference type="HOGENOM" id="CLU_449519_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1989-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="602" mass="63688" checksum="FC56729BE473A736" modified="2012-11-28" version="1">MDPAQAILAFLMVVVTAASGIVVDSNSADSTSQSDSSPPVPIAPDPVSIMADAFGQMFGLTVKAFTDGLAGAFGWILDSVGGEQGVYYFLVKLPVADPSVNNGGVETAILEVYPLIQNVALFFFVFVLLMAGLSYAVENFGILKEGTASHILSSSLFTLVVLFLILPIYNTTATMFNVITDPSSGMILKNGEITGLLKAAISPEFVNVPQGIVQTILSVFVFILVLVELLAVAILGTLRIFFVGAILVMMPLILILRLIPLTKGVADSLIEMEVGLILASLIAAIFLKFGYEVATEWGGLLSVLAAFGTLVATALMPTVLAPKVGSVFSSTVSMVTTAGTGAAVIGAMAGGGALAAGTSVMQTAGGFGKVFGPSTKFAGGSTFADIGNRVVGFTDGLRIMAPAMTLGGTKGYGKGLLEATKGISIGPNALPDKIQVSRQSMQGLDSIRSSAPYKTALLHMQGTISDMAFKPIEGESAKHGWQYINDIMDLDDKQLSDILARSLGQPSLSTKPEETAEKFRNDLNLMKQNPILASRISLNLRKVEEKGQLPKHTISNLLGLRQEFPSKLRNSVETLRQEKRLKERKMNYSDTIVSLSSLFPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR7</accession>
    <name>K0IIR7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c29210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59840">
        <property type="protein sequence ID" value="AFU59840"/>
        <property type="gene ID" value="Ngar_c29210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2898"/>
    <dbReference type="HOGENOM" id="CLU_027562_2_2_2"/>
    <dbReference type="OMA" id="ANLERYC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2921-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="454" mass="53492" checksum="433808F94E00D200" modified="2012-11-28" version="1">MALTEQLPPSQLEKTIVLLTANLERYCRSLFLKLANTNSENAQILADFITAEQNEINIKDSTKEWKIKIIFQLSAFHEHAKSFKDMTKDDILAYLNKLRKPESEDPTHKWIGTYNNRQMLLNKFFRWLYNPDEPDHRQRITPPCMRGVKRLPRKEKSPYKPSDIWTNEEHAVFLKYCPMKRDRCYHAIAYDTSARPHELLRLKIKDIKFKLSPDGIQYAEILVSGKTRPRTLPLISSIPYIKEWLQEHPLRNNPEAALFLSLGDSNYGRPITRDGLWWHFAKHYRTKYFPRLLEEPSVPATDKEHIKSMIAKPWNLYIFRHSALTQKSQILKETTLRDHAGWTMSSKMPQVYLHYFGTESSNSLLEAYGIIKHSQKQIEILKSKACPNCNEPNKPDERFCFKCKMVLTYDAYKDTLDQEQAKEERLKVVQDQLQALYRQLYREGLIKEQPRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT7</accession>
    <name>K0IIT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59875">
        <property type="protein sequence ID" value="AFU59875"/>
        <property type="gene ID" value="Ngar_c29570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29570"/>
    <dbReference type="HOGENOM" id="CLU_1933327_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2957-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="15149" checksum="CF6BAB63281ABE2A" modified="2012-11-28" version="1">MVVLSFWHCLAKIYVKNWHTLAFHLQAHMHWALDTVRNAPNILMLKGYVVHAAIDDLGTEKVLEEERDNVRNYRQFCSTLAFTRGYSDNLRYVWPRSIYLSRRRQLLSGMLAGKNGAADLEITCPTPKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU9</accession>
    <name>K0IIU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative TatD-like deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20770"/>
    <dbReference type="EnsemblBacteria" id="AFU59008">
        <property type="protein sequence ID" value="AFU59008"/>
        <property type="gene ID" value="Ngar_c20770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20770"/>
    <dbReference type="HOGENOM" id="CLU_031506_5_2_2"/>
    <dbReference type="OMA" id="DGPYEYR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2075-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="251" mass="27808" checksum="50BDE5E355D80130" modified="2012-11-28" version="1">MLFDAHIHLTDNEYSGYIEHVLTSLRAMKIVACSVTVDSETAFRSFRLFNSHHDIVRQFVGIHPEAAAREDLDKFKEIFDSNLQSIDGVGEIGLDGTYDVPYDRQKQVFGSMLALAESAKKPVSIHSRKALDDVLQMLPSYRIKGALLHWFAGSKKQLAKSMDMGLYVSYGPALVYLEDKQVLLKNTDRNRFLVETDGPVRYSRCFGNLPAVSTGFLVSVVASAARTLGMTYDEAAGLLEQNSKAYLSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ12</accession>
    <name>K0IJ12_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acyP</name>
        <name evidence="5" type="ordered locus">Ngar_c30790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30790"/>
    <dbReference type="EnsemblBacteria" id="AFU59995">
        <property type="protein sequence ID" value="AFU59995"/>
        <property type="gene ID" value="Ngar_c30790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30790"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3051"/>
    <dbReference type="HOGENOM" id="CLU_141932_3_2_2"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10476" checksum="B1FC8FB68DB963C3" modified="2012-11-28" version="1">MSDKKTRAHVLVSGKVQGVYFRQNTKQVATQHKVAGWVRNLPDGRVEAILEGDEAAVNEVIKWCHVGPPKASVQDVNVKFEKYTGEFAGFDISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA9</accession>
    <name>K0IJA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.35" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14000"/>
    <dbReference type="EnsemblBacteria" id="AFU58337">
        <property type="protein sequence ID" value="AFU58337"/>
        <property type="gene ID" value="Ngar_c14000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14000"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1362"/>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_2"/>
    <dbReference type="OMA" id="SVMEVFY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1398-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="191"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="385" mass="42821" checksum="1ECDD19C954D7606" modified="2012-11-28" version="1">MSLSTINKITVLGSGVMGHGIAQVSAMAGYNVVLRDIEQSFLDKAMEKIKWSLSKMVEKQKLSQADADRIFARITPIVDLKQALKGTDLLIEAVPEDMNLKKKVYAEVDSFAEAKTLYASNTSTLPITEMAALTSRPDRFIGLHFFNPPQLMPLVEVIPGGRTNQSMVDMAMGFVQKVGKQPVLCKKDVAGFIVNRVFIPLVHEAVYCQERDNNVPMTTIDSAVKFKMAFPMGIFELADYTGLDVIHKATVEMHSRDSKVIRPHPKVKQLFDEKSLGQKTGKGFYEYKGDKYERINLTEQEAAKYNPIALLAVAANNAAWLISSRVCSKEDLEKALKLGMGLKKELFATVRDFGPSNVVNTLRDLAAKHGSFYEPDQYLVNYRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF4</accession>
    <name>K0IJF4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59278">
        <property type="protein sequence ID" value="AFU59278"/>
        <property type="gene ID" value="Ngar_c23530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23530"/>
    <dbReference type="HOGENOM" id="CLU_2379507_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2351-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10049" checksum="404F0619DED2B49C" modified="2012-11-28" version="1">MIRNGRLLFTLIITAILKSSLIFAIDTQAFACSYVGPRPPAQMMQESDAVFSGFVIAASNADATFSIENAWKGVSEEVVTLLSGPGDCSYIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF8</accession>
    <name>K0IJF8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59288">
        <property type="protein sequence ID" value="AFU59288"/>
        <property type="gene ID" value="Ngar_c23630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23630"/>
    <dbReference type="HOGENOM" id="CLU_2271127_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2361-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11462" checksum="9D7D77494FFE6A95" modified="2012-11-28" version="1">MEVISTQGTFTANVEWIPADIGQPNNFSFNFRDGDGQPVTPAYDVELLRDNQMVPGTLRESQTSLEQEYTFNEAGNYTLRIHNVQTKHPGDVINIPLQVPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJU2</accession>
    <name>K0IJU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein containing KH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34500"/>
    <dbReference type="EnsemblBacteria" id="AFU60365">
        <property type="protein sequence ID" value="AFU60365"/>
        <property type="gene ID" value="Ngar_c34500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34500"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3448"/>
    <dbReference type="HOGENOM" id="CLU_064992_3_0_2"/>
    <dbReference type="OMA" id="DPLAVWK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3451-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="200" mass="22717" checksum="7DD79A873D60DD2D" modified="2012-11-28" version="1">MSFQHTMKIPKDRIGAIIGKGGKVKQQIEKRCGVEIEIDSESGDATISSTKPVEQMEAFRAVEVISAISRGFSPERAYRLFENDEIMFQQMDLHDYAGKSPNALERIKGRIIGEGGKARRMIEELSGAYISVYGHMVGFIGNFKEVKLASDAITLLAKGSMHKSVYNMLQDARRRDKMDRMRLWEDTYDNDKEEIKPSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJV0</accession>
    <name>K0IJV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c16140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16140"/>
    <dbReference type="EnsemblBacteria" id="AFU58547">
        <property type="protein sequence ID" value="AFU58547"/>
        <property type="gene ID" value="Ngar_c16140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1582"/>
    <dbReference type="HOGENOM" id="CLU_309646_0_0_2"/>
    <dbReference type="OMA" id="LIPYVDF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1612-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="969" mass="108470" checksum="05EF6659D35B6132" modified="2012-11-28" version="1">MWDTYNEDRARRTDIGRIVRIAVFAAIGVIIFGLVSNQSVNLLMNLEEFGEVFTKPLYYSILSGIILAAIVFVRVNFKARHSATWYSIKMLINFLKRGDYESQSKMSRYSEFQMGKTSFAFWQLTKVVLFAPLFANIMFGMAAEYIIQGNDIGLSSIGNIFAIPFADITTDGSYAQQNVMPMFPALTLLIPPLLAAVGLRLLLYVGVTSVVNIASQYAIDSKESKPKFLSYISTIEIIAGAAVFWIGFNMFFSINIDYNTRYAIAGAMTLGAAFITFGFVDRRHAKVIIYPTKRLVYSRLFTAAVIIGLAGSIMIVNNSIAETRKIEWNGPYIAQQIEVNRFMHGLDKIETKNYDIAQPPVSPSAIQSVVEQNGDVLGNIRLWDEANAEAKLKQQLGQRSDLGYFDFDVLRFNGEMYWTGTTVPVIPNTVASRDTWFNQHFIYTHSDVGMKMLEADTGNIVDESQFFNQRRIYYGESGNGGLFSTYWSAYPVTGTRSEEVGGAFYNGTGGVNVAPPLSWMFEPNFMAYSNTPVHVMRYKDIHDRMELLYPYFVYEFCFDCTQNNPQPKEVEAFVVTDGTRTYWLMPLIVAINTSNVPWSSATSTSFMLQLVGYSLIDAYDGTVQIIVTGNDYFSQMFFEQYRDIGATREVPRWLADQIRYPEEMFIWQISKFNTYHVTDPKAYIETKDFYSIADDSNEVVPYYAYAKPPEFESPEFVGLQPLQLKEPQSNSLVGYMTVQNDLEDLGRMTFFSIPRDSPTKLISPAAAKTTLTGSAEYKEAKRALFGDTNPPLGQVSLYKVGDYEVYFIPVFADTGGKQVGIVGAVGAASTTGTHYVGLGNTPAQAFENYLQKLSGVAPTDQPPVVVINQTAPDRQSKIQNLEKVFIDAGLTVIKPTAVSAPVEFREAQGVYRADSDLSQAEAAIQSFIQEFAPEGGRIFEWHDGTTVNFGVLREVEGIVENHYISIEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK76</accession>
    <name>K0IK76_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Elongation factor 2</fullName>
            <shortName evidence="6">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ordered locus">Ngar_c27120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27120"/>
    <dbReference type="EnsemblBacteria" id="AFU59633">
        <property type="protein sequence ID" value="AFU59633"/>
        <property type="gene ID" value="Ngar_c27120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2689"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_2"/>
    <dbReference type="OMA" id="GVMTQTE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="6">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="733" mass="81006" checksum="02DE501C47C345FC" modified="2012-11-28" version="1">MPKFKSTQDILRIIGNKDQIRNFGVIAHVDHGKTTMSDSLLAASGIISPSVAGQALALDSMKLEQNRQMTIRGANVTLFYETDGKEYVINMIDTPGHIDFTGRVTRALRAIDGVVVVSDSVEGIMTQTETVTRQALEERVRPVLYINKIDRLVKELKLGPEEMQKWLMNIISHFNQLVDIYAEPEVKEKWKVSIQGNSVAFGSAKDRWGFNFKMAKKTGINFKDVYDAYTSNDPALIKSLSERSPLSDAVLGMVVEHHPPPHVAQRYRIPKIWPGDLNSDIGKALLACDEKGPALMMVTTINVDPQAGRVATGRLYSGTIKDGDEVYLIDAKRPGRVQSVNIYMGNTREIVSVLPAGNIPALLGLDYAIAGETISTVKGAQAFESIKYVSEPVVTIAVEPKHPKDLPKLVEGLRTITVEDPNLIVKINEETGETLMAGMGVLHLEIATSLLQEKGLEIVTTQPLINYRETIRAKAGPIMSKSPNKHNKIFMRVEPLPDDILEMIRTGKIKEDMDKKEMAKLLRDKGWSADEARSVAAIDVSGNMLVDETKGVQFLQESMDSIRSGFDDVIRNGPIAHEQVRGVKFVLHHFVPHEDPAHRGLAQLMPATRRAMLGSMLIADPVLLEPILGIEIKCPQDLIGQVSSVLSGKRGKLLNVEQKGIIAIMQGEVPASETFDLSEKMRGATAGKALWNTYFKAWQPVPNSIFRTLVGDVRKRKGLNPEPPSPDEFIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK78</accession>
    <name>K0IK78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59638">
        <property type="protein sequence ID" value="AFU59638"/>
        <property type="gene ID" value="Ngar_c27170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27170"/>
    <dbReference type="HOGENOM" id="CLU_2985482_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2717-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7410" checksum="E738C9992897B36E" modified="2012-11-28" version="1">MFIMSASQSLAVQDRKYHKKKALVEKFIKKSGKIDHSVILNNVDVDYDTLMRILSDLRSEGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK90</accession>
    <name>K0IK90_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17890"/>
    <dbReference type="EnsemblBacteria" id="AFU58722">
        <property type="protein sequence ID" value="AFU58722"/>
        <property type="gene ID" value="Ngar_c17890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17890"/>
    <dbReference type="HOGENOM" id="CLU_099500_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1787-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15998" checksum="144A5F80D0FEA87A" modified="2012-11-28" version="1">MKINKVVETCIYSSDLDSMKKFYVEILDLPLVQEEKNKLVFLRAGKSMLLIFNPAKTSIDNYRLPTHGAQTPPASIHFAMEIEEHDYLRWKELLAKNRIAIEKEVDWNGSGSGGGSRSLYFRDPAGNLVELITPGEWPVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK99</accession>
    <name>K0IK99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59663">
        <property type="protein sequence ID" value="AFU59663"/>
        <property type="gene ID" value="Ngar_c27420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27420"/>
    <dbReference type="HOGENOM" id="CLU_1458237_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2742-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="18899" checksum="02E294D8115B46E1" modified="2012-11-28" version="1">MFRPIKHVLRTPKYRTIALASGLAYAIIYIITVGIISYVPGLSSASGIPVFRTSYLGISAIPTDNIFFFIFYGALAFLVASSFLVGINTALMFYSRRVAKVCGIQKKPESKGLFGIVPAFFTSFSCCGGGLLALAIGPAAFSSLSIYSKFMAPLTVVVLAAGTYFVSKKIAKMERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE5</accession>
    <name>K0IKE5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58872">
        <property type="protein sequence ID" value="AFU58872"/>
        <property type="gene ID" value="Ngar_c19400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19400"/>
    <dbReference type="HOGENOM" id="CLU_1393618_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1938-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="195" mass="22054" checksum="01AA524E3B55BC22" modified="2012-11-28" version="1">MVAAKELGIKARIRYINAETQFDSVVAVLNPYGEVYPEVDVKENISIQKIFSYVKNGGLFINVADVPLYYAYNSMLRRFVDTTEPVVTSAQEQHGAFEVGFTRFFQLNIIARELRLSLVGFSSGLQCNINHVIGSTGMVGLHKGQITSRRSVIIESNIETCVEPLPVTYQGQKKMTPILRKIRRWRFFALTCLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE8</accession>
    <name>K0IKE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59713">
        <property type="protein sequence ID" value="AFU59713"/>
        <property type="gene ID" value="Ngar_c27920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27920"/>
    <dbReference type="HOGENOM" id="CLU_1782544_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2792-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="16073" checksum="74E7B89ADE91E0AF" modified="2012-11-28" version="1">MSDEVGVTIPTIAGLAVGVALIVAFASFAKPAFTMSDDEVRQKVRNLPEVQAFYERYTPLEQIRHQGTTTYVEYQIGKTWYFSNDPTALQDDVTKSLRLYVKVDPYGKTSVALDCMSMSGGNSLPATIEMIKTTSCIEQPEQDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH9</accession>
    <name>K0IKH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb9</name>
        <name evidence="7" type="ordered locus">Ngar_c28530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28530"/>
    <dbReference type="EnsemblBacteria" id="AFU59773">
        <property type="protein sequence ID" value="AFU59773"/>
        <property type="gene ID" value="Ngar_c28530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28530"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="WEINRIC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="327" mass="36081" checksum="DA444A2658DE009E" modified="2012-11-28" version="1">MLSKHSSRPDDEQCSACGSPPITDNFTGELVCSSCGVVLKERVETLSPEWRSFSSADNRARGGFPSSLLIYDTGLSTYIGTTFVQDQKQQGGDQENNNNNKNEGGSVYVHRASCPIPVNRLRKLNAMSVSSAPVSRNLKKATWEINRICSSLGLAWQVAERSAYFYRKALQKNLIKGRSISGFVAASVYLACKERMIPRTIDEVCRATGVDRPFATRCYKILVSEMHIEPPPITDPFRNIAKISTRAGIEERVSRRAMEILSSVTSHTTIMGKNPLVLAAAALYLATVEHKLNMTKTMIADAAEVSTISLRKRLADITCALEDLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKJ1</accession>
    <name>K0IKJ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20400"/>
    <dbReference type="EnsemblBacteria" id="AFU58972">
        <property type="protein sequence ID" value="AFU58972"/>
        <property type="gene ID" value="Ngar_c20400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20400"/>
    <dbReference type="HOGENOM" id="CLU_2271125_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2038-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11535" checksum="5447D2D00A20548D" modified="2012-11-28" version="1">MMLQMSARDIMSKPVITIDAMGSIRDALQTMELNNIRRLPVIDKEKKIVGIVTDKDIFRALMRSQSLVASFCESLLVEYRPVYERLGEFMLGEVPFPGGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKL7</accession>
    <name>K0IKL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59027">
        <property type="protein sequence ID" value="AFU59027"/>
        <property type="gene ID" value="Ngar_c20960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20960"/>
    <dbReference type="HOGENOM" id="CLU_2044491_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2094-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13790" checksum="18215475C9CF3D64" modified="2012-11-28" version="1">MLLEGVLAIFAQSFGLTYSWLNENLIAPFMAFTRGFEFAVVFMAAALFFAISVFLLLKQAKKLPKSYAIEIIDLYGEQVSIDGVRQTFATHDAAESYARMYRDNFGYQYRFKVVGITDPGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM5</accession>
    <name>K0IKM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59848">
        <property type="protein sequence ID" value="AFU59848"/>
        <property type="gene ID" value="Ngar_c29300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29300"/>
    <dbReference type="HOGENOM" id="CLU_1280834_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2930-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="215" mass="23536" checksum="CD4A51B71C9B6C49" modified="2012-11-28" version="1">MSSIPPSGPQVEVTLYSIFASRKRNPVEEERQAQVAAITTTMIPSNFQVYAKIDEESRKDNRLTVSFLLTLNDVKGSVTYEFRGVCNIMGSTADFEAIMEAHKDSRIPKILDIIYQRLYPVVFMLAGMTTSSYPQSIALLTEMVSSEPIQVHQEAEALPKPEEKPKAPEKPAAEGVKPVPTAAEVEAPKPAMAKVKKPLQQPSTGDDAAKAAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKV7</accession>
    <name>K0IKV7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="6">2.3.1.182</ecNumber>
            <ecNumber evidence="6">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuA</name>
        <name evidence="6" type="ordered locus">Ngar_c22420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="6"/>
    <dbReference type="EC" id="2.3.3.13" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22420"/>
    <dbReference type="EnsemblBacteria" id="AFU59172">
        <property type="protein sequence ID" value="AFU59172"/>
        <property type="gene ID" value="Ngar_c22420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2222"/>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_2"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011830">
        <property type="entry name" value="LEU1_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02090">
        <property type="entry name" value="LEU1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="511" mass="55159" checksum="B4A68A6F703A3C93" modified="2012-11-28" version="1">MSKANSNNNNDNNKVRIFDTTLRDGEQTPGVTVTPDQKVQIAIKLDELGVDAIEAGFPIVSQGEMQAVKTIANQGLKAEICGLARATEADINAAIKCDLKYVHTFIATSDIHMQYKLKMTPEQVMDKAVKAVEYAKKHGMQVEFSAEDATRSDRQFLLKVFKAVTDAGADRIDIPDTVGYRTPDYIAEIVRDVKSVTALPISVHCHNDFGLAVANAIAGVNAGAACAHVTINGLGERAGNASLEEFVMALEILYNKKHNINTKLIYETSKFVSNAMGIIVQPNKAIIGENAFGHESGIHTHGIINNPLTYEPIAPELVGRKRWLQAGKHAGAHGIRAMLEDFGIKPTDEQLKQIVEKQKNIADKGKSITTSELLAIAGEIMGSTEFEEKFKLYDFHIVTGMNIIPTAVVRLNADGKDLIASNTGVGPVDAALKAIQKIAGEVANVKIRDFMLDSITGGSDALAVVTVKVEDKDGNIVSAKKAGEDIVVASVQAMMDAINKVLLRKVLYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKZ1</accession>
    <name>K0IKZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59222">
        <property type="protein sequence ID" value="AFU59222"/>
        <property type="gene ID" value="Ngar_c22950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22950"/>
    <dbReference type="HOGENOM" id="CLU_1727298_0_0_2"/>
    <dbReference type="OMA" id="AYENIAD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2293-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="17233" checksum="6379797F73C7AD2E" modified="2012-11-28" version="1">MVDTKSPSKDETRASDIYDTMRDNLIRTVDEFAKVQPQYSQSISNLQLDYIQTTKNMIQTAFAAQKQYASIWNIPSVPYGDLFTRQSNEMTNNAIRSVGINNQLTINALDAARENLKIYNRTVDAVTDFSTNVAKAWTTFFAQQQAQFTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL88</accession>
    <name>K0IL88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60238">
        <property type="protein sequence ID" value="AFU60238"/>
        <property type="gene ID" value="Ngar_c33230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33230"/>
    <dbReference type="HOGENOM" id="CLU_2476124_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3323-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="10021" checksum="1455C748BBB91684" modified="2012-11-28" version="1">MIKASCQQALFVIALAEEMPALEKITTAEHKFDGFFPAEKCTSIMFFPAYILISLLYKFEVSPKECCRRKIEKIGQEQGQKQHQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD8</accession>
    <name>K0ILD8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-3B methylase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
            <ecNumber evidence="6">5.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiHC</name>
        <name evidence="6" type="ordered locus">Ngar_c25240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EC" id="5.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25240"/>
    <dbReference type="EnsemblBacteria" id="AFU59447">
        <property type="protein sequence ID" value="AFU59447"/>
        <property type="gene ID" value="Ngar_c25240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25240"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2502"/>
    <dbReference type="HOGENOM" id="CLU_047948_2_0_2"/>
    <dbReference type="OMA" id="VWDDRMV"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="305" mass="33916" checksum="721334A08E319FCF" modified="2012-11-28" version="1">MRSWSTTATANRQSGRCMTSLSLPELREKDKWHLVNPNVANMSGNKGKLYVVGVGPGSHDHMTHRAKQVIDESQVIIGYDTYVSLVEDLIIGKEVYRYAMTQEVDRANQAIDFAEKGKVVSLVSSGDPGIYGMIGLIYEILAEKGWDREKGIYVECVPGVSSLNSCAALVGSPLMTDFAVVSMSDLLVPWEIIVKRVEAAAIGDYVTVIYNPASKKRVHQLRDTREIFLKYRKPDTPVAIVKGAYREGQQVVITTLDKMLEHQDMLGMITTVIVGNSSTFNYKGMMINPRGYTSKYELVKQPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE5</accession>
    <name>K0ILE5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amoA</name>
        <name evidence="2" type="ordered locus">Ngar_c25350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25350"/>
    <dbReference type="EnsemblBacteria" id="AFU59457">
        <property type="protein sequence ID" value="AFU59457"/>
        <property type="gene ID" value="Ngar_c25350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2513"/>
    <dbReference type="HOGENOM" id="CLU_1329513_0_0_2"/>
    <dbReference type="OMA" id="MAAWSKW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024656">
        <property type="entry name" value="AmoA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037001">
        <property type="entry name" value="NH3/CH4_mOase_suA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12942">
        <property type="entry name" value="Archaeal_AmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="22987" checksum="A0DB6BEFB418247D" modified="2012-11-28" version="1">MFIVVVAVNSTLLTINAGDYIFYTDWMWTSFVVFSISQSTMLVVGAIYYMLFTGVPGTATYYATIMTIYTWVAKGAWFALGYPYDFIVVPVWIPSAMLLDLTYWATRRNKHAAIIIGGTLVGLSFPLFNMVNLLLVRDPLEVAFKYPRPTLPAYMTPIEPQVGKFYNSPVALGSGAGAVLSVPIAALGAKLNTWTYRWMAAWSKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH2</accession>
    <name>K0ILH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase, pepF/M3 family</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF</name>
        <name evidence="9" type="ordered locus">Ngar_c01290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57079">
        <property type="protein sequence ID" value="AFU57079"/>
        <property type="gene ID" value="Ngar_c01290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.131"/>
    <dbReference type="HOGENOM" id="CLU_021290_3_0_2"/>
    <dbReference type="OMA" id="HPYMWAV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="208"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="605" mass="69594" checksum="D4CD07CAC13B1E78" modified="2012-11-28" version="1">MTTTAYTTMKVGRWNLADLVEDPSSDQFGSFLRSIEEQLAQFERSRQILRQDISPVEFEGLLHLLESISEKISIASGYAHLRYYADTSSNEASALVIRMEKMASDIGNRTLFFDLWFKRQLDDENANRLINAVPQVYREYLRHKRLVAKYSLSEPEEKIINTLEVTGIGALVKIYDKMTSGFEFTVKLRRGRKIVEKKFDNKEKLVSLVRSPDANTREAAYKSLLEVYRKNSGVLGEIYQNVAVQWRDEAISMRGYKSPISVRNIANNLDDVTVEALLASCRKNSAVFQEYFREKAKMLGMKKLRRYDLYAPITTKASDTKKFTYGKAVQSVLDTFGDFDPQFRTLAERVFSERHVDSEIRKAKRGGAFCYTVTPKMTPYVLLNFDGLTRDVSTLAHEFGHAIHSMLASDLPIMVSHAPLPLAETASVFAEMLLNEKLAEKMSARERRLLLAEHIDDMYATIMRQAYFTLFEIEAHRVIAESNATIDAVAKIYFENLNEQFGSSIAITPDFQWEWVYIPHFYHTPFYTYAYSFGNLLVLSLYRQYKLEGKSSFVPKYFKILAAGGSRKPEELLMEAGIDISREEFWQQGFDYVREMIQQLKSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH5</accession>
    <name>K0ILH5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60423">
        <property type="protein sequence ID" value="AFU60423"/>
        <property type="gene ID" value="Ngar_c35100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35100"/>
    <dbReference type="HOGENOM" id="CLU_1237954_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3511-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="228" mass="25689" checksum="A78AC09B10D1077D" modified="2012-11-28" version="1">MDVHITQFNVQLYFKQPILGMDRLNAAFSESEGFSASQMRPGDHPMQDTMSFFRQGFRIAPVQSNVLPFRILQVMSYPNALQNPDQDTMSCLHYVAAALRQHLGADIENDIYAVRVVFHSIVTGKDNNIHRILTKLDSIEGIPSLAGKYVGHKNPMDAIQLTSKTGNELSQKFWNDMRISQFDTHSYVVTIFNETDSLAAALDFIRGVRQFVATLMREMEEAAAVKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ2</accession>
    <name>K0ILJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59512">
        <property type="protein sequence ID" value="AFU59512"/>
        <property type="gene ID" value="Ngar_c25900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25900"/>
    <dbReference type="HOGENOM" id="CLU_2613756_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2590-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9327" checksum="B45DEC1A928A8192" modified="2012-11-28" version="1">MIVYNDVNTSNMWPSYSKYTLEEEDAIVLLATHYEHVNMVKDALRDYYDINVEDHEENGSLIIRDCQRLSREDAWQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ6</accession>
    <name>K0ILQ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative CorA ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">corA</name>
        <name evidence="7" type="ordered locus">Ngar_c26860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59607">
        <property type="protein sequence ID" value="AFU59607"/>
        <property type="gene ID" value="Ngar_c26860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26860"/>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_2"/>
    <dbReference type="OMA" id="VFKTVCY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="320" mass="36781" checksum="9F11251C2F3930BF" modified="2012-11-28" version="1">MSDPEKRLETISNNGVLWINLQKPSFSDMSTLGQKYPFQRLNLEDSLSKIQIPKIDRYADHIFIILHFPTPDKEKGFLFSQLAVFMGPDYLVTIHQGDLKPLDELFNMCKNDEKQRQAIMGKSSGYLLHKIIDTLVDDLLHILMKVVGNIDDIEDSVFDERISIPRQISLLRREITTLRRIVIPLRRTVVDLSKDVQRFSKEDMSLYFKDVLDHIEKVYEALEEAKETVEIYKDTDFMLSNEKTNKILAVLTIIFTLSIPATVIGQFYGMNIPLPGGNETGPWTQLGPYTTLIFVIVLSSVSALLMVFYFRRLGWLGPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ8</accession>
    <name>K0ILQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57244">
        <property type="protein sequence ID" value="AFU57244"/>
        <property type="gene ID" value="Ngar_c02960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02960"/>
    <dbReference type="HOGENOM" id="CLU_1140595_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-296-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="243" mass="28757" checksum="2C31306ED8FCD24D" modified="2012-11-28" version="1">MSKQLLLNEIERLYIEGIEPKENLRDELYVKKNYPHLDSLFAQYRSENEKWEQLVREVLFYDKQDITYMYNRTMLLVRRFGQATTDYFRSSSPTGTYILPDRLSDLNRMFELYHEFFSDIYPGIINELNFGIYAHERISNEISGVINWNKTILYSLERGTARVPIEFATSVPKPDFETPENQLLIISILRMRYDATFLLTYPFSEELSLQEKEILTRISTGCSKILKNTILHELIPKSSNIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR8</accession>
    <name>K0ILR8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="2">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mqnD</name>
        <name evidence="3" type="ordered locus">Ngar_c27110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27110"/>
    <dbReference type="EnsemblBacteria" id="AFU59632">
        <property type="protein sequence ID" value="AFU59632"/>
        <property type="gene ID" value="Ngar_c27110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2688"/>
    <dbReference type="HOGENOM" id="CLU_070326_0_0_2"/>
    <dbReference type="OMA" id="RGCGPLV"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="30560" checksum="001C86C1C62A57DB" modified="2012-11-28" version="1">MEITLGHTPDADDAFMFYGIASGKVRSGFAVKHVIQDIETLNRRALKHELDVTAVSAHAYAYLNDYVILKSGGSFGLNYGPIVITKKGSSKVTTPEQLQKATIAIPGKMTSANLLLKLAIGGRFREIEMSFEAIPDAVATGKVDAGLVIHEAQITFDKTKFASALDLGRWWSDNMGGLPVPLGINVASTRTMSKSQITEFSDIFTKSIKYGLDNIDAAVRYAMQYGRGQPKETITKFVKMYVNELTLNMGRSGKQAIERMFEIAKEKKIIDADVAVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILS9</accession>
    <name>K0ILS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03270</name>
        <name evidence="2" type="ordered locus">Ngar_c03560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57275">
        <property type="protein sequence ID" value="AFU57275"/>
        <property type="gene ID" value="Ngar_c03270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57304">
        <property type="protein sequence ID" value="AFU57304"/>
        <property type="gene ID" value="Ngar_c03560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03270"/>
    <dbReference type="KEGG" id="nga:Ngar_c03560"/>
    <dbReference type="HOGENOM" id="CLU_1182906_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-327-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="234" mass="26764" checksum="9D3BDBFFD2E7B7BE" modified="2012-11-28" version="1">MTYRINFCQGELSEHVAIIGDGKVGKTSFARDHLLRKLPGTFKKWCYDYNHNGFIGIGPPVRSLDALIDANMQYLPQEKSKEELNGFLEVALRLGNRVVAIDEFHAQQNSKSIPKPTQVFLKTFRHVSGSWIVIAQSPLELHDDVYHNADHIFAFFMKPTSRHTAWYYEKFGQPMTFKLMELHYEAVQLKAKRPYIYTGASSIEAVIYSHKGKFVQRFDAKGKPIIVQLKGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT5</accession>
    <name>K0ILT5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57324">
        <property type="protein sequence ID" value="AFU57324"/>
        <property type="gene ID" value="Ngar_c03760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03760"/>
    <dbReference type="HOGENOM" id="CLU_3039173_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-376-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6234" checksum="FF9AAA33A03667A6" modified="2012-11-28" version="1">MWVSVGDKFKPFFQSPLFGDSRFNLNVLFASCSTIFPFQSPLFGDSRFNLVQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ9</accession>
    <name>K0ILZ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59837">
        <property type="protein sequence ID" value="AFU59837"/>
        <property type="gene ID" value="Ngar_c29180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29180"/>
    <dbReference type="HOGENOM" id="CLU_516418_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2918-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="527" mass="61050" checksum="BC0C615BEC4FE367" modified="2012-11-28" version="1">MTQSSDAQANFEAYLQYLSYNDDRLLINGESKYPILLPQRVSKESIENAVYEYCQKYNIDYVSTENVNKWSIAMVKEYHLQRLKPKGKVEKTTTAQESKEQPIVLTDDLTREVTFQEVSAILSTSIKKDEAAKLITFCGMLLAQSNEDQLNLGFQSESSAGKSYIPIEVASYFPKEEVEILASASPTAFYHDGKWDNEKKVLFRDLEHKNLIFLDQPHFQLLEKLRPLLSKDMKELYYKITDKNQRQGLRTKNVIIRGFPSVFFCTTRTDPDEQEKTRMILLSPSTDQEKLRESLELVSLKKSNPEEYRKRIQHDPRRSWLVDRIKAIRQWGIREVLVPNDGKDVYERFMKEHAYLLPRHQRDFPRIFSFIKAHALLNCFKREKVLNGHADKPVAIIANQADIDAGFELYKEIEQSNELGLSPYIFKIYREVIQPLLNPQVGLSRKEIRSKYYTVFHKTLAAKLEESVIMQLEGAGLIEQSPDPEDKRKMLVYPTVSGNISSDRKCIPQDSGATPLEQYPREVQPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM01</accession>
    <name>K0IM01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59842">
        <property type="protein sequence ID" value="AFU59842"/>
        <property type="gene ID" value="Ngar_c29240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29240"/>
    <dbReference type="HOGENOM" id="CLU_1987693_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2924-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="15006" checksum="F1BE2A5BBCFA5EC6" modified="2012-11-28" version="1">MDFEKIIAHSPNPEAAIRAAYKLELCEEMIRLTNELERDIAKLNTREKLAFYEMIGSKEMVEFLQEKLWNKEVDAQLNLYMLIEERKRHGLKVDPDIEKWLRYDPHELLERRKRELGLSGNPMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM28</accession>
    <name>K0IM28_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 1A</fullName>
            <shortName evidence="1">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eIF-1a2</name>
        <name evidence="1" type="synonym">eif1a</name>
        <name evidence="4" type="ordered locus">Ngar_c30150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30150"/>
    <dbReference type="EnsemblBacteria" id="AFU59932">
        <property type="protein sequence ID" value="AFU59932"/>
        <property type="gene ID" value="Ngar_c30150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30150"/>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="OMA" id="LGGNHVR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10439" checksum="2B565D55F990314D" modified="2012-11-28" version="1">MKEMVMPQEGELLGRVIKLVGGDNIIVKCTDGKVRTCRIRGKIKRRMWIRDGDLVLIAPWDFKSDRADIIWRYISAHAEKMKADGLLQGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM36</accession>
    <name>K0IM36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59962">
        <property type="protein sequence ID" value="AFU59962"/>
        <property type="gene ID" value="Ngar_c30460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30460"/>
    <dbReference type="HOGENOM" id="CLU_1830652_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3046-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="14721" checksum="8125D3C8DBD461C8" modified="2012-11-28" version="1">MAIDPVKVKAADFINDGGTIKAINGTTSTVDSSSTSAATVIQYAIDNLPTTGGRIHMKSGTYTITSTITVNKAGIGIQGEGDGTLLQCNGSAVSPMFAMADTTKRSFNNFENFRMQSTSLGNGLAFNTSYFTRSVFQALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM40</accession>
    <name>K0IM40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57539">
        <property type="protein sequence ID" value="AFU57539"/>
        <property type="gene ID" value="Ngar_c05960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05960"/>
    <dbReference type="HOGENOM" id="CLU_2857206_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-594-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7493" checksum="0C3828C1E24CD72F" modified="2012-11-28" version="1">MTIIFHVGKRRTVIGSTCAELAQVIHAIYLHTWEQTECDLYRFWPEMVVKLTELIATKNTNKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM42</accession>
    <name>K0IM42_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisD</name>
        <name evidence="11" type="ordered locus">Ngar_c30660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30660"/>
    <dbReference type="EnsemblBacteria" id="AFU59982">
        <property type="protein sequence ID" value="AFU59982"/>
        <property type="gene ID" value="Ngar_c30660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3038"/>
    <dbReference type="HOGENOM" id="CLU_006732_3_0_2"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="430" mass="45609" checksum="358B2004B70C3B05" modified="2012-11-28" version="1">MKIINVAEPAIGAARLRKATAIPDSLFADAMAIMKSVAEHGDSAVLDYTAKFDGVRLDSLKVGEHEIKHAYRQVTKEQVRAVRLMKERLAKSELAVLKQLKGIAVSAEGVRINRMVKPVASVGCYIPGGKARYPSTVVMCAVPAKAAGVKRIVAVSPPMKDGTIDPLTLVAADICGVDEFYKAGGAQGIAALAYGTQSIKPVSKIVGPGGMFVTAAKLIASGNVSTDMVAGPTELLIYADTTADPRLVAVDLISQSEHSTDTICGLVTTSEKLASQVHAQVQSLVEKITRSDIVKSSLENNGFIAVCKNESECIEFVNEFAPEHLEIMCKNADAVAKKIDSAGLVLIGQYAPSSASDYSLGSNHVLPTLGFGKSRASLSVLDFIKIVNKVKVSKAGLAKVDRSVKEMAVAEGLLNHYEAVRARTEDDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM59</accession>
    <name>K0IM59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57584">
        <property type="protein sequence ID" value="AFU57584"/>
        <property type="gene ID" value="Ngar_c06410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06410"/>
    <dbReference type="HOGENOM" id="CLU_1567206_0_0_2"/>
    <dbReference type="OMA" id="DINTVRM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-639-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="19357" checksum="9D7BFECCD57146FA" modified="2012-11-28" version="1">MKAEQFSKNVLSLDPEIRFAGVMEKSGHLYASVRKNGTEEYLKGRSPEISLAQSAYIVDLRKMFTQELGNLKSIIYDYEKVKLISMPVKEHVLVISTEPKVNADHLVEKVIKYVKSVESELSLYPPSNIVNEEKKETLRNLHHSGISEDLIAEQLDLDINTVRMLIAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM71</accession>
    <name>K0IM71_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC uptake transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mntB</name>
        <name evidence="5" type="ordered locus">Ngar_c06710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57614">
        <property type="protein sequence ID" value="AFU57614"/>
        <property type="gene ID" value="Ngar_c06710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06710"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="256" mass="28284" checksum="A0C5536ED25679E1" modified="2012-11-28" version="1">MGTEDKTVSRKNNNVNALELKEVTSGYSYNRPVVEGINLQVPKGGFVGILGPSGSGKTTLLKIITGLHKPWYGTVEFYHYNNGGKPVIGYVPQVESVDWTFPVTVREVVSMGIWNQSGTGPMINKVAGEKIRYVLENLGIEEYMTRQISELSGGEQQRVFLARAMIRFPDILVLDEPTSGVDYNTRETILEVLANLNEKGTTIILTTHDISGIAKRLPWLVCMNKHIVSEGPPTEVLTTENLLETYGLVDTESVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM91</accession>
    <name>K0IM91_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">atpB</name>
        <name evidence="9" type="ordered locus">Ngar_c31910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31910"/>
    <dbReference type="EnsemblBacteria" id="AFU60107">
        <property type="protein sequence ID" value="AFU60107"/>
        <property type="gene ID" value="Ngar_c31910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3175"/>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_2"/>
    <dbReference type="OMA" id="MLMMDSV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="7">
        <location>
            <begin position="136"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="464" mass="50850" checksum="7AFBECF3E28C265E" modified="2012-11-28" version="1">MPETAAGVEYTKVAEIKGPLMVIDGITKASFDELVEIETADGERRLGKVLEVGFGKAIVQVFEGTTGLTITGTKAKFLGKTMEMPVSQELLGRVFDGLGRPNDGLPDPIADKFLDVNGEPMNPERREYPTSFIQTGVSVIDGMLTLVRGQKLPIFSGSGMPHNILAAQIARQATVVGTKEDFAVVFAAIGVQYSEAQYFKRSLEESGALRRSVLFLNLADDPAIERIITPRVALTVAEYLAFDLGMHVLAILTDMTNYAEALREISAAREEVPGRKGYPGYLYTDLANNYERAGRIKGKNGSVTQVPILSMPADDITHPIPDLTGYITEGQIVLGRDLFRKGIYPPVNVLMSLSRLMKDGVGEGKTRSDHMEVGNQLYDAYSRAQEVRALAEIVGRAGLTGVDLKYLDAGDMFEQHFLKQAPDENRALDETLGRAWDVLSSLPEGELTKIKEKHVKQYYKGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA8</accession>
    <name>K0IMA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c32310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60147">
        <property type="protein sequence ID" value="AFU60147"/>
        <property type="gene ID" value="Ngar_c32310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32310"/>
    <dbReference type="HOGENOM" id="CLU_1217619_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3231-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="25114" checksum="384095BDDB91B941" modified="2012-11-28" version="1">MEVGDLATILPLLSIFSSLGMSFVFKDYIADLIATVVIKKTKDIKVGNRIKITNGGATTKGDIMEIGILRTTVMEVGDGERLPSVRTGRLIKVPNYMLISNPVMIYGDTIIDEVVSYIPRPYPDSQLLEESMKQAIINNGHGLIEVGLYQKDDRLVIHGVFEVKTSEMGDERSKILREFLIRSRQIGADSNSAGKDSQVQKPAGAQQQELLVEPKVTIPLQNIEKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME0</accession>
    <name>K0IME0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57829">
        <property type="protein sequence ID" value="AFU57829"/>
        <property type="gene ID" value="Ngar_c08870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08870"/>
    <dbReference type="HOGENOM" id="CLU_136580_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-885-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="180" mass="20103" checksum="B3C98069DC860470" modified="2012-11-28" version="1">MAKVRPSITLKLKSGQTITLDLQEVNDIIKSLTKFVNERQRRLRRRQNIKDATTAVVKRRIARNGRMMITTTRKAGRKIPAASSSMSQAKRQEILEHVNKKLSTEPKTLSNLLKGVSYSPNYLPAIRNIIENQPNIAKQIIGKRTYYRTITSKNGEKKHRVSSGQSASSNASSLSAAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH5</accession>
    <name>K0IMH5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DprA_WH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60287">
        <property type="protein sequence ID" value="AFU60287"/>
        <property type="gene ID" value="Ngar_c33720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33720"/>
    <dbReference type="HOGENOM" id="CLU_1821077_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3372-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15844" checksum="9D0CA74F44D213FD" modified="2012-11-28" version="1">MIRQIGVKWLLFENQRAEKLGALDIQVLSCIKANAQTEKQLAKKTGIDILTLSPLVTELMLMGYVETFRRRRLLFFSREYVSITPEGLAALEKAKSPLQNIIELIRERALEALENVAASSPALKILFVLGKATYRTAKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP2</accession>
    <name>K0IMP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58069">
        <property type="protein sequence ID" value="AFU58069"/>
        <property type="gene ID" value="Ngar_c11270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11270"/>
    <dbReference type="HOGENOM" id="CLU_1615360_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1125-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="16923" checksum="CBE37B89F249090A" modified="2012-11-28" version="1">MAVAILSSFIAIQSIVNAPAAAQAPAANNVVVYIFKRDTSKFQWAGDLESKVSAAIGVNTVKDKNTGASKAGIYDASDKLVDGASVQFVIDPSVTKADGTLLTVADIPNDMAFGNGVTVGGIQLANGEIVDTIHFVFSSADAATVTANLEKIRQILATESPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMS5</accession>
    <name>K0IMS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58149">
        <property type="protein sequence ID" value="AFU58149"/>
        <property type="gene ID" value="Ngar_c12090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12090"/>
    <dbReference type="HOGENOM" id="CLU_2021577_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1207-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="12781" checksum="D59CCC867E5C8BA3" modified="2012-11-28" version="1">MNNKRYMLVLLLTILLIMAGAFAQTPSANDTGQQPTEEKQGGEYSGLEETGEQNEGLPRQGADPSPDAPITGVEPQQDQPTETAEVAKPASPLGIPMLAGIGAAVAAGIVAAAWYFRKNRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX8</accession>
    <name>K0IMX8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cutA1 divalent ion tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14630"/>
    <dbReference type="EnsemblBacteria" id="AFU58399">
        <property type="protein sequence ID" value="AFU58399"/>
        <property type="gene ID" value="Ngar_c14630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14630"/>
    <dbReference type="HOGENOM" id="CLU_098807_3_1_2"/>
    <dbReference type="OMA" id="VYTTFPD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1461-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13255" checksum="503745AEFAC8D7D7" modified="2012-11-28" version="1">MASSGTIILSTFPSEKSVVDVADKVVRDRLCACVNFTQIRSIYSWRGKIEDQKEFVALFKTTATSAKRLKAEIARLHPYEVPEIVELKMQDVSRPYLSWLAESTDGVPKKRHNAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN06</accession>
    <name>K0IN06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58539">
        <property type="protein sequence ID" value="AFU58539"/>
        <property type="gene ID" value="Ngar_c16060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16060"/>
    <dbReference type="HOGENOM" id="CLU_2476120_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1604-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9442" checksum="67C1505B82A0643D" modified="2012-11-28" version="1">MPIDAAEFDAHKDLATIITQFLCRNRDKGFSAKEIAQATGISEADVNSAMFKLGLSDLASAIAGRKKKIRIEDVTIGGTTYYRCVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN38</accession>
    <name>K0IN38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative histidine triad protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c17660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17660"/>
    <dbReference type="EnsemblBacteria" id="AFU58699">
        <property type="protein sequence ID" value="AFU58699"/>
        <property type="gene ID" value="Ngar_c17660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17660"/>
    <dbReference type="HOGENOM" id="CLU_056776_3_2_2"/>
    <dbReference type="OMA" id="RGFFWPR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1764-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="15766" checksum="1DB54BB545FDD7B8" modified="2012-11-28" version="1">MSKSCIFCAIIAGQEPGALVYRDSNFVVIMDKYPINPGHTLVMPVKHYEDLLHMPPAEVGKLHALVPTIAKAVVSAVKADGFNVGQNNGIAANQIVPHVHVHIVPRFNDDSPDGKWPARRVAPQEELAKIAHKIKQEITLIPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN74</accession>
    <name>K0IN74_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58879">
        <property type="protein sequence ID" value="AFU58879"/>
        <property type="gene ID" value="Ngar_c19470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19470"/>
    <dbReference type="HOGENOM" id="CLU_2712968_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1945-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8321" checksum="E666475AD55ADBDD" modified="2012-11-28" version="1">MSNDNICKNTVRLPKITSVRKLTRILNDAMRNGEKKLVKETVLENTETAKKAIPYLNMKYRHYVRKVLEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF2</accession>
    <name>K0INF2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59269">
        <property type="protein sequence ID" value="AFU59269"/>
        <property type="gene ID" value="Ngar_c23430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23430"/>
    <dbReference type="HOGENOM" id="CLU_1665555_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2341-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="17276" checksum="6A72669E8E2035D8" modified="2012-11-28" version="1">MAAMPKSIKLAIIFGTVGIAIGIGATFLIMNNQTEGQVFQQVVEFGDDNPWTDPSFLKSYNENIRTGAHYKTRLAVGEEGFFMSGAKGGKEPYTYEWKFSDGVTLNAANVTRSFDSAGRYYFDLIITDADGKQGKSTAMYVDVLGQLPEEEATNSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING6</accession>
    <name>K0ING6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59339">
        <property type="protein sequence ID" value="AFU59339"/>
        <property type="gene ID" value="Ngar_c24140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2387"/>
    <dbReference type="HOGENOM" id="CLU_076511_0_0_2"/>
    <dbReference type="OMA" id="PDCHNCC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2412-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="27956" checksum="A89D43287EE34B49" modified="2012-11-28" version="1">MQADTSVKDALDLLAQKWKIDPKLYDLQTGRRDDVVDNPVNVGGVVFHIPVLSKDNLYVLWKCLWPDCHNCCERQGRLPLTKDDIKMISRKIGYASEPEFLKNETLVSTWQEQGMLGNIITTLTMISLKRKVDERPDQDGTPLRCRFLDDKGYCGIHPDKPGVCWLYPFASWLEADARGQPVVHATFQFTGDCPGFYLDKSMDSMMPVLQEYSAKIYSYNMAVSRTTRENYGTVNFVDVRKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH3</accession>
    <name>K0INH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59374">
        <property type="protein sequence ID" value="AFU59374"/>
        <property type="gene ID" value="Ngar_c24500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24500"/>
    <dbReference type="HOGENOM" id="CLU_1405924_0_0_2"/>
    <dbReference type="OMA" id="ENDNDEC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2448-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="18824" checksum="1784D3AEEA723DB9" modified="2012-11-28" version="1">MSSKPSYWFKDFVGVGYRYHDVYMNVFPLFEDKIAAFRLWKKTIEWWPDDAIKLRFVEQDDSYWFILYGGSNYTGDNTGFVKKVPVSENYERFKVGYEKKAILRFGIYKENVKKKKDGSKFDLEVLKKSKSVYDIAFMKYDELAQDSIEWQCIQENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL0</accession>
    <name>K0INL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp21</name>
        <name evidence="4" type="ordered locus">Ngar_c26370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26370"/>
    <dbReference type="EnsemblBacteria" id="AFU59559">
        <property type="protein sequence ID" value="AFU59559"/>
        <property type="gene ID" value="Ngar_c26370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26370"/>
    <dbReference type="HOGENOM" id="CLU_046737_9_5_2"/>
    <dbReference type="OMA" id="YPPVDMY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14248" checksum="922C3AE931CCC5A0" modified="2012-11-28" version="1">MGIGGYVARSIAKELDNRSREFYEFVMPAIDMVEDGSDLVVTIDLPGFAKKDINLWITGNVLSISAKRGQEEALGTVYYRHRPVRIEKKVLLPISVKEEDKVVGKATYENGVVTLRVPIPKTTNIPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT7</accession>
    <name>K0INT7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59944">
        <property type="protein sequence ID" value="AFU59944"/>
        <property type="gene ID" value="Ngar_c30280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30280"/>
    <dbReference type="HOGENOM" id="CLU_2821044_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3028-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7991" checksum="AC073DF0A5387D9A" modified="2012-11-28" version="1">MSKPQIMHRVYLSYVQATDYLSLLTERRLVEYDAYTQTYNITERGQRFLRKYNQIGEVIGKMQIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV0</accession>
    <name>K0INV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60009">
        <property type="protein sequence ID" value="AFU60009"/>
        <property type="gene ID" value="Ngar_c30930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30930"/>
    <dbReference type="HOGENOM" id="CLU_1567211_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3093-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="17968" checksum="F69F41AC5517234D" modified="2012-11-28" version="1">MAIAVGFVTWVAIIAIVLVAIGLGVGVFFSGLIRGAEIVGERISESAVVREAQDFVEDRVDAGSSDRILVVTTDEATYDAGEPVTITVKNIGDRTLAFPDTSLGLEIVHAGSGQKYNVPSAKMITELAPGESKEITWDEEGAPAGDYIATVHTTPEEEDVSAQVRFMITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV3</accession>
    <name>K0INV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60024">
        <property type="protein sequence ID" value="AFU60024"/>
        <property type="gene ID" value="Ngar_c31080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31080"/>
    <dbReference type="HOGENOM" id="CLU_3021096_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3108-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6183" checksum="2773461557295E24" modified="2012-11-28" version="1">MAPLLPALFCMLKEKRITEESAKSRIGRFTKILLVGKMGVHPINPIVRCIEGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV8</accession>
    <name>K0INV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c31330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31330"/>
    <dbReference type="EnsemblBacteria" id="AFU60049">
        <property type="protein sequence ID" value="AFU60049"/>
        <property type="gene ID" value="Ngar_c31330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3110"/>
    <dbReference type="HOGENOM" id="CLU_057821_0_0_2"/>
    <dbReference type="OMA" id="DFDDQQY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3133-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="198"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="384" mass="43092" checksum="65B377F05FE7E9DD" modified="2012-11-28" version="1">MQTYMAASRVTKKDQKKKGAATAATGGGVLGIHHITAITRNAQRNIDFYSGTLGLRPVKITVNFDDPTSYHLYYGDYMGHPGTLLTFFVWPDIHKGTRGTGQVTTVAFLIPPKSLEYWVDRLRRNGVSVVGPSTRFNDAEQFISFHDPDGMMLELVAPSSVSSYVHSKKKIQNEDVSAINYYNVWKEGPVDAQHALRAFHSAAISEEGYEHTASLLTDTMKFQLVAKDEREGRFRFKAINNRKLGEVPEAIGSVVDVVCQPDITRGIVGIGSVHHIAWRASDDSHQLDLRRRIIKQAHLDPTPVIDRKYFHSVYFREPGGVLFEIATDPPGMTIDQKPEELGTKLTLPEWYEPLRSKLEQEVLPPVNLPPRNMTKQHKEESSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6V2</accession>
    <name>K0I6V2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00310"/>
    <dbReference type="EnsemblBacteria" id="AFU56981">
        <property type="protein sequence ID" value="AFU56981"/>
        <property type="gene ID" value="Ngar_c00310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00310"/>
    <dbReference type="HOGENOM" id="CLU_945330_0_0_2"/>
    <dbReference type="OMA" id="KMNKSMQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-31-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="294" mass="32733" checksum="39A9DEA93FFD0D99" modified="2012-11-28" version="1">MDVYRPEKFVVESGQLQHSFKWLMSYYSYYKKCKVIAKEILDKRAGLVVSDEDFASIAIGEEMGRRRVLITDITETHFTTGPASMIERKMNKSMQKMIQACDCVIIPDAGDDYGNIRHVGPIVRQASAGRDALRKQFGFTRNTIVVSTGGTDAGRYLIEKAIEAHRKLQSRLDSELVVVSGPSLKLPDSPDYRNLGFVDNLHELVYAADLVISLAGRSTIDESIAYGTPGIFIPIKGHFEQEEGAARLGFKYEDIFRLESLVEEKIGRRNNNNAVHAAGGGAERAAKIISDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6Y1</accession>
    <name>K0I6Y1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00710</name>
        <name evidence="2" type="ordered locus">Ngar_c09360</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57021">
        <property type="protein sequence ID" value="AFU57021"/>
        <property type="gene ID" value="Ngar_c00710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57878">
        <property type="protein sequence ID" value="AFU57878"/>
        <property type="gene ID" value="Ngar_c09360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00710"/>
    <dbReference type="KEGG" id="nga:Ngar_c09360"/>
    <dbReference type="HOGENOM" id="CLU_2930302_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-71-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="7030" checksum="5A4633AEAACF59EC" modified="2012-11-28" version="1">MCMYSTVIRFVIYNTALQQNQGSERKQHQDCYNGSCSKDDVCVRAIYVMLKEERSFRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7I3</accession>
    <name>K0I7I3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57196">
        <property type="protein sequence ID" value="AFU57196"/>
        <property type="gene ID" value="Ngar_c02480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02480"/>
    <dbReference type="HOGENOM" id="CLU_128582_0_1_2"/>
    <dbReference type="OMA" id="YTMSERE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-248-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13727" checksum="7EECEF5319E0C789" modified="2012-11-28" version="1">MPASDDLDKLCDRIFAADSNIRFVGAIDKMGTLVAGGMRKGIKPLEPREDRRKLYLEFALRNAMRSEFDPEYGKTIYTMSEREKIKIASFPYGDYLILISIEKKAQHDKVIAKVLKLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7P2</accession>
    <name>K0I7P2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57271">
        <property type="protein sequence ID" value="AFU57271"/>
        <property type="gene ID" value="Ngar_c03230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03230"/>
    <dbReference type="HOGENOM" id="CLU_3094223_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-323-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5646" checksum="D2173C574EE5C7F5" modified="2012-11-28" version="1">MRDTIANLFPYDPRFDQLIKSGAKVEITLKQPLAEKAPVPAQPVKAESPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7X8</accession>
    <name>K0I7X8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57371">
        <property type="protein sequence ID" value="AFU57371"/>
        <property type="gene ID" value="Ngar_c04240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04240"/>
    <dbReference type="HOGENOM" id="CLU_3148090_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-423-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="48" mass="5373" checksum="6ABFFE19B4FBBA5B" modified="2012-11-28" version="1">MPFVIGALIIGSEMQYIIDYYVRSSSCYFPNCPDVVPGYEGTCLGQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7Y8</accession>
    <name>K0I7Y8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04390"/>
    <dbReference type="EnsemblBacteria" id="AFU57386">
        <property type="protein sequence ID" value="AFU57386"/>
        <property type="gene ID" value="Ngar_c04390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04390"/>
    <dbReference type="HOGENOM" id="CLU_718874_0_0_2"/>
    <dbReference type="OMA" id="LINAAFM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-438-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="5"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="380" mass="41044" checksum="4EF770AB6553AB68" modified="2012-11-28" version="1">MISRAVLLVAICAAIVGVSYGMHSPIVPVFARDQLAADYSQVGLIGTINYLPYMFAPFFFGMLLDRLNKSYMLVSGVLLNMFSIFMLSTVQSVPEIMLYRTLAGVAHALFWPSAEVLVSTNTTPDRRVKSISTFIAAWILGFMVGPLIGKLILDVFNYIMLFQLAAAIMAAGMVPSMLLRRYGWPAVQKDLEVRAGTVQIMREVAARPTLSSVILYYAITFGVVLAVLPAYMNEASLTSQDIEVLFFLFGISRFATLMFVPRISVYGVLALALAVLATAIAMLLAFVFTSFLSFAIAIALVGLATSIFYPVTFSLVTRDTPSGQIGAKLGIYNALFGSGWTAGPIVAGLSSDAFGSGSPYFAFFVAGSILAGSIVMFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9G3</accession>
    <name>K0I9G3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative translin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10490"/>
    <dbReference type="EnsemblBacteria" id="AFU57991">
        <property type="protein sequence ID" value="AFU57991"/>
        <property type="gene ID" value="Ngar_c10490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10490"/>
    <dbReference type="HOGENOM" id="CLU_099315_0_0_2"/>
    <dbReference type="OMA" id="FAETVIY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1047-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="19761" checksum="BCF32FE6268DE0B4" modified="2012-11-28" version="1">MVMSCSKSIVALHHGQIDDAKSKMEEAKTMLEEFRKYAKEDLYRYISVAEQELVEAYALRAVMENTPIPSMQDLDVTGPSYLTGLLDCVGEIKRLVYDRMRSGNEKDAEKLFATMEEIYNAIYPFAVYDNIVSGLRKKLDVARILIEDIRAVVTEENRRKALIDAIDGLDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBX8</accession>
    <name>K0IBX8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01050"/>
    <dbReference type="EnsemblBacteria" id="AFU57055">
        <property type="protein sequence ID" value="AFU57055"/>
        <property type="gene ID" value="Ngar_c01050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01050"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.109"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_2"/>
    <dbReference type="OMA" id="RDPWSVN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-105-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="363" mass="39742" checksum="77E458DCEC70130B" modified="2012-11-28" version="1">MGQKVVASKGMSACSHGGVYSVNPRLVKVDCSSSINPLGTPLKAIAAIQKGAKSLAPMYPDPECRELKKSLSRYLRIGDPEWISVGNGAMEIIYWFAQAFAKGSRVVIPAPTFCEYELASHKSGAEVTFVPLHNFELDADEVIEKARGAGAVFLCNPNNPTGMLSTKGIRKIIENIDSSTKILLDECFIELVDEPDTNSMIGMIEKFDNLVILRSLTKSFGLAGLRVGYSICNPALAEKLSANRIPWNVNGLAQAAGVAALAADRMHLPRARAIIKKERKFLHDSIGRLKSFKPLRSDANYFLIHLQGKNSTQFRDALLKKTGVLVRDCSTFTGMEGSQYVRVAVKSHMENLHLLKALEEFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBZ2</accession>
    <name>K0IBZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gcn5-related N-acetyltransferase (GNAT) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19040"/>
    <dbReference type="EnsemblBacteria" id="AFU58836">
        <property type="protein sequence ID" value="AFU58836"/>
        <property type="gene ID" value="Ngar_c19040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19040"/>
    <dbReference type="HOGENOM" id="CLU_1182907_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1902-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="234" mass="26201" checksum="38D129832FC8ADC7" modified="2012-11-28" version="1">MWTERIRSGCATALLNSKLEGDYFFSRASVSGCSDTAAVAVQVAKVFWKKRLDCYLYDADGSLTGKGLDQIDTMYVLKAGKAGGRTIKTRVLQIDRPLLPVWIDVFCRSFAVPEWKEEVERIMDVNFDRLELLLSYRDKVPAGCAALYSKNGVTGLYCLGTISQLRRKGLANDILATAAQRSDNLFLQTLGSEELLPFYKKAGFVVAYTKKIYVLRRANKLKSLKKPCSEINLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC62</accession>
    <name>K0IC62_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58941">
        <property type="protein sequence ID" value="AFU58941"/>
        <property type="gene ID" value="Ngar_c20090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20090"/>
    <dbReference type="HOGENOM" id="CLU_2353302_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2007-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="10887" checksum="0A08BF6CAD825EB8" modified="2012-11-28" version="1">MKGTLDSITASSKWIEQTLSSKVRIRILVFLAANRGRAFSRYKISSATNVSAKEVSKHMKILVEAKLVKTVSGGVMLYSFDEGELALLFAEFLRRCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC71</accession>
    <name>K0IC71_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c01910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01910"/>
    <dbReference type="EnsemblBacteria" id="AFU57140">
        <property type="protein sequence ID" value="AFU57140"/>
        <property type="gene ID" value="Ngar_c01910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01910"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OMA" id="VCTKELC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-191-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="18329" checksum="15E77CBE721F8AD3" modified="2012-11-28" version="1">MSSASLASVPNIGDKAPDFELPDPDMKPRKLSEFYGKKTILAFFPAAESPVCTAEMCALRDSLDQLRDLGANVVGISVDGPFANKFFVQNRHLNFPVLSDYRRDVIKKYGIVMNKLGPLEGYDAAKRSVFILDEKGKVIYRWVSDNPLVEPNYNEIKDALKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICA5</accession>
    <name>K0ICA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59001">
        <property type="protein sequence ID" value="AFU59001"/>
        <property type="gene ID" value="Ngar_c20700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20700"/>
    <dbReference type="HOGENOM" id="CLU_2766237_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2068-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7758" checksum="B13A3D4E24F1856C" modified="2012-11-28" version="1">MRNKPYLPFCRLSGLNEQRNCLRLHMLAIGPIKGKYVNFAHKKVKKATEHNAAACRKSNAVTTASETMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICA6</accession>
    <name>K0ICA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20750"/>
    <dbReference type="EnsemblBacteria" id="AFU59006">
        <property type="protein sequence ID" value="AFU59006"/>
        <property type="gene ID" value="Ngar_c20750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20750"/>
    <dbReference type="HOGENOM" id="CLU_1076055_0_0_2"/>
    <dbReference type="OMA" id="GECPRTG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2073-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="256" mass="28049" checksum="3C15987F6A45E51F" modified="2012-11-28" version="1">MITIRLLGGAKKAVGKPAVDLDRQSASVAEILQFLTGISTDARLLQPNNLIVAVNGVDSAALQGQGTVAKSGDTVTIVTVVHGGTDYYMIDSNHRVSIIGIRRITEDAGKLVDRLRSEHPGVSIQAVNADAVYGIDHLLGVLRVTLEAEKRKVMLANRRETELLLRLARTDQISDAMKKAGLKNGSAGCLIAISQENEELRHFSESIKNRFEVDDSVLEPSRQKRDLLTGMLELKAKFDDHEFLQYLLERAAILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID25</accession>
    <name>K0ID25_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS</name>
        <name evidence="9" type="ordered locus">Ngar_c23560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23560"/>
    <dbReference type="EnsemblBacteria" id="AFU59281">
        <property type="protein sequence ID" value="AFU59281"/>
        <property type="gene ID" value="Ngar_c23560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2331"/>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_2"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="408" mass="46551" checksum="238FC2511248E899" modified="2012-11-28" version="1">MVKVVSGRRLFKRLTSSCCKQSMDPEDQSIASSNDDFKVTPWEVEGEVDYGKLIEKFGTQPITPELLQKVKGMTGEVHPMLKLGYFFSHRDFDWILDKKIKGENFYLYTGRGPSGMVHMGHLMPWMFTKYLQDKFDSKLLFQLTDDEKFLYGQDRTREEIARYTYENILDIIAIGFNPKKTKIIVDTKHIQHLYPIATEVAKRITFSTARAVFGFSNSTNIGMIGFPPVQAAPCFLPSVIEGKPTPVLIPAAIDQDPYWRMTRDVADRMGYYKPAQIHSKFLPGLGMLGKMSSSKPETAIFTTDDPEVVDRKVSTAFTGGQPTVALQRQLGANALGCPVFWYLRYFFDTEKQSDERMLKCRSGNLLCGECKADLTKGAKPFVVEFKKRREKAKDVVDRFMYDEKPFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID82</accession>
    <name>K0ID82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC1</name>
        <name evidence="10" type="ordered locus">Ngar_c06770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06770"/>
    <dbReference type="EnsemblBacteria" id="AFU57620">
        <property type="protein sequence ID" value="AFU57620"/>
        <property type="gene ID" value="Ngar_c06770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.654"/>
    <dbReference type="HOGENOM" id="CLU_013181_2_2_2"/>
    <dbReference type="OMA" id="PYFVFGP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="448" mass="49237" checksum="C1534BADABB4409C" modified="2012-11-28" version="1">MVQVAKDEDVGLNWLVQRVANGSIIIPKNNARKQKIKVVGIGHGLKTKVNVNIGTSTLHQNLDEEISKAKVAVKYGADTIMDLSDGGNLDTIRQTLLEAAPITFGTVPVYQAYWHGVEKYKNPLNITEDDFLNAFEKNVKDGVDYTTIHSGITKELAKRVLEVKRHGGIVSKGGTITAAWMLKYDKENPYFEHFDYMCEIARKYDVTFSLGDALRPGSILDSHDELQVAEMINVARLAKRAHEKDVQVMIEGPGHVPLNEVAANVRLAKSLIGDVPYYVLGPLVTDVAAGYDHIASAIGAAVSAAEGVDLLCYLTPAEHLALPTAEEVKEGLIAYRIAAHAGDLVKIRDKAIKWDAAITEARRTLNWEKQIALSINPEEAARIHYREGQHEGNNVPCTMCGSACVYIMLPQQRQQKQRRIDITSNNDDIYNDGGGVKEESTATMSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDF3</accession>
    <name>K0IDF3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Na+(Li+)/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c25030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59426">
        <property type="protein sequence ID" value="AFU59426"/>
        <property type="gene ID" value="Ngar_c25030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25030"/>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="OMA" id="EAKWIVS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2502-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="5"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="407" mass="42541" checksum="41A206672D915BC5" modified="2012-11-28" version="1">MDLAVIMVVAAIMLAITFKLKQPMVIGYIIAGMIIGPYTPPFSLVSSIETVSLMAEIGIILLLFTVGTEYPIAKLRSIGGKAIVIALSEALGTFAIGYFVGQQMGMALFDSLFLALSISVTSTVIVMRVLEELGMVREESAYLLLGVAVIEDIIIVSMLAILQSVASTGDLAFQEITVVVGVVLAFIGGVLFLGSRTIPKLVDIMGKTDRYDLILITVLAVAFGLSFIADAIGISVATGAFFAGVLVAESKTQAVAKIITIPLRDMFGAVFFISVGALMDIRLIPSFIVPALILIATSFGAKFGTVFASAKMLGLSKKVSARAGFGLSASGGELALVTAKGGADVGATSAFLLPMIGAMTIITTFLSPYVIRLGWKITKSPEGEPAKGNDNNSNKAKDTETSGAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDM9</accession>
    <name>K0IDM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57800">
        <property type="protein sequence ID" value="AFU57800"/>
        <property type="gene ID" value="Ngar_c08580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08580"/>
    <dbReference type="HOGENOM" id="CLU_798335_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-856-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="370" mass="40661" checksum="FF6D76174B2291C9" modified="2012-11-28" version="1">MNDNNGRKRTFALMPAAIIAASMLVLSIAVFPSAMQGQTVLADEYNDNHRGDIDRTVQRTANTDALPQPNDEKKVLTAEATNAVFQPAAGLSNVFGPGGLFPFENVFDCADSLECGVSAGDNAKFVGVFEEGNENELTGYEATYTSPITYGDQQMEGHQYKIELTDLKWNSSDAAMPTRQPEFAQMVNNVGLDQIQHGSSHIDRSDVPQLKVAFLYGHAKVTDLTEDRVVAEDIFTHVMVGHIMDEDAFYRSMKDLPASPDLVLLFAVNIPNDTELPGVGQLSAEQAQSFTPLPEDVSLDNPPPVDYPVEIPAPRQGTIDEPEPQSTTWPVANPEQPLFFTFLVYQDTEVKLTTIDDIVGDNYDNNKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDN3</accession>
    <name>K0IDN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57805">
        <property type="protein sequence ID" value="AFU57805"/>
        <property type="gene ID" value="Ngar_c08630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08630"/>
    <dbReference type="HOGENOM" id="CLU_3113191_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-861-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5859" checksum="6DC8EC5857A3F8BD" modified="2012-11-28" version="1">MDRAFNLFYLWLALLAPRIAKIDNRWQSATISNVRIAYSLCAPVVLWFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDS3</accession>
    <name>K0IDS3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56963">
        <property type="protein sequence ID" value="AFU56963"/>
        <property type="gene ID" value="Ngar_c00130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.14"/>
    <dbReference type="HOGENOM" id="CLU_2613744_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-13-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9215" checksum="3B88A6166E9AECD9" modified="2012-11-28" version="1">MYDPDDPELQTMASGIINAVKRYSIPYERLTGQEIWEELQRKGYRFPVSGRRIDFLYESARWFDALDLAIKKLKSEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDS6</accession>
    <name>K0IDS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57880">
        <property type="protein sequence ID" value="AFU57880"/>
        <property type="gene ID" value="Ngar_c09380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09380"/>
    <dbReference type="HOGENOM" id="CLU_1665551_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-936-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="18916" checksum="E70A7EECF2F7E876" modified="2012-11-28" version="1">MTDSATGEKCTFRLYAVSKYWKKRYRRRKKKHGVQYMYYATGNGVNIPVERMFDLYRQRFGIESSYRTMKKSRGRTSSKSAVLRLLHILVSFVIQNEWVYIKWQYLSKTTRGRYGKKYDTRFTYFRMRQFLRLALEMVYSAVNSVQMKNGRSVTILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDW1</accession>
    <name>K0IDW1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00580"/>
    <dbReference type="EnsemblBacteria" id="AFU57008">
        <property type="protein sequence ID" value="AFU57008"/>
        <property type="gene ID" value="Ngar_c00580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00580"/>
    <dbReference type="HOGENOM" id="CLU_2766230_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-58-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="8215" checksum="FE395682B61B72E6" modified="2012-11-28" version="1">MSSEIEETRFNLIHEHERTGESVTNNICRRKYGVSRKTCYKWKNRYLARGIDGLKDNSRKPHNIGHRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDW6</accession>
    <name>K0IDW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57013">
        <property type="protein sequence ID" value="AFU57013"/>
        <property type="gene ID" value="Ngar_c00630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00630"/>
    <dbReference type="HOGENOM" id="CLU_3210872_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-63-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="44" mass="5185" checksum="881EEED6FB99B325" modified="2012-11-28" version="1">MKESRYVKMARTMLHVLKHARMPLFLHNRKSKTIYSQSGSTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE05</accession>
    <name>K0IE05_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">cobD</name>
        <name evidence="13" type="ordered locus">Ngar_c01030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01030"/>
    <dbReference type="EnsemblBacteria" id="AFU57053">
        <property type="protein sequence ID" value="AFU57053"/>
        <property type="gene ID" value="Ngar_c01030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.107"/>
    <dbReference type="HOGENOM" id="CLU_054212_0_0_2"/>
    <dbReference type="OMA" id="WGYRNER"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU57053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="320" mass="34460" checksum="F4F863C1822C73E6" modified="2012-11-28" version="1">MLLGLLAALAAGVGVDWLFGDPPNKYHPVAWLGRLVGYCVPRLKGGAEKAKGAAFAVLLVIAVALAVHFLVFASMYLAGIVALAIASAIILKITIAVRGMERHAKAIMSCLETGDLAGARQNLSMIVRRKTNDLDEQHILSATIECVSESTVDGITGPIFYYSLFGPVGAFAYRAINTLDSMVGYKDDYFKDIGWMSARLDTAANYMPARITALLMIVSAKMLGADWKNSLSVLQRDHAKTFSSNAGYPMATMAGALRVRLEKIGHYALGDDQEPASLEKCKTAISIMKLTTLLFCIGVSAPIISILYLAGWWRLVLGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE48</accession>
    <name>K0IE48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11080"/>
    <dbReference type="EnsemblBacteria" id="AFU58050">
        <property type="protein sequence ID" value="AFU58050"/>
        <property type="gene ID" value="Ngar_c11080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11080"/>
    <dbReference type="HOGENOM" id="CLU_2230463_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1106-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11423" checksum="47DCB73D549DA22C" modified="2012-11-28" version="1">MVRDHGIENVLVLQGGGSLGAFSCGVFKAFAERNINIEILAGTSIGGINAAIIAGSKDRHPEVALEQFWLELAETSVDLTPRWEPPIDNESGSYYQYLAISHHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE70</accession>
    <name>K0IE70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58075">
        <property type="protein sequence ID" value="AFU58075"/>
        <property type="gene ID" value="Ngar_c11330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11330"/>
    <dbReference type="HOGENOM" id="CLU_1521920_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1131-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="20141" checksum="93A4B801EAF74869" modified="2012-11-28" version="1">MHPLIQEAMRITEDLGDVVFIGAVGIFLQTKATRESQDLDFAVAKELPAELLDEKRYFVRKVKGKEARYTPRGYKIDIYTRDVSGIPIDRVVATAKDIEVRKGVTVKAAGVEVLVVSKFRAAAKRRGTDDVDIRTLVQRKYNAIDWDVLKSLTDSEIEYQRIRNQMDALHRMQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEF5</accession>
    <name>K0IEF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59716">
        <property type="protein sequence ID" value="AFU59716"/>
        <property type="gene ID" value="Ngar_c27950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27950"/>
    <dbReference type="HOGENOM" id="CLU_1599072_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2795-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="166" mass="18601" checksum="B71594B82C5542F9" modified="2012-11-28" version="1">MRNICPRCGARGKIVSGKIVAAAIVGIAGLVAVYYALFNSEGISTIQNVLKSTTNEDVSVLPSGGAASRTPIATYRYCYSAIRGDLGKNGYIDTQCYEKFFAPFMREVDNDELANFKFTLPYELSDMTTIRTESSVYKYGENEFELGLYDQVGEKRYHVKLWEYPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP1</accession>
    <name>K0IEP1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29020"/>
    <dbReference type="EnsemblBacteria" id="AFU59821">
        <property type="protein sequence ID" value="AFU59821"/>
        <property type="gene ID" value="Ngar_c29020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29020"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2880"/>
    <dbReference type="HOGENOM" id="CLU_083287_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2902-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="161" mass="18271" checksum="4CAC96F3389FC037" modified="2012-11-28" version="1">MKEREQTIQAIIEKLGEMSAETVMFHQGVADVLGLHITDHKCLGLVHRFGAMPAGRLAELTGLTTGAVTGIIDRLEQAGYVKRTDDPKDRRRTIVEPVRNKKLERKIETIFVPLHKRMHKLLSSYSDSELDFLLTATTELIAQTREESRRLRAGGKDEHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEW1</accession>
    <name>K0IEW1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CRISPR-associated protein, Cas5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas5</name>
        <name evidence="2" type="ordered locus">Ngar_c03850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57333">
        <property type="protein sequence ID" value="AFU57333"/>
        <property type="gene ID" value="Ngar_c03850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03850"/>
    <dbReference type="HOGENOM" id="CLU_1227688_0_0_2"/>
    <dbReference type="OMA" id="FRVHITM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="25296" checksum="B9419579BABB84E2" modified="2012-11-28" version="1">MIKALVVEVSFFEALFKVHYTKGFRQSYLIPLPTSVAGIFGAMLGISRNNLHQEFHDILFGAAIKRYKGIVGENVTFFQDKPSNPTIGVAKTLIVNEPTYVIAMSGSVNRLEVFMEKLSRQVEYLPYGGQNDFFVKDFQVHSNLVDVENCDIVNNYAPSSWVDEIKSDGKTEIQILPVMHKLDASPNFHFILDGSLKLSRTVSCVKAYGIGLYSLHDFYLTGDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA3</accession>
    <name>K0IFA3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c31350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60051">
        <property type="protein sequence ID" value="AFU60051"/>
        <property type="gene ID" value="Ngar_c31350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31350"/>
    <dbReference type="HOGENOM" id="CLU_124258_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3135-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="23822" checksum="A89CDF2F7419C484" modified="2012-11-28" version="1">MSSSGYSEDDIRRAADIREWLIKQIEDKQEEVERLRTTLAIIDNLLKQGSFKAAASIGFATAAGGGGPTATTAQVQQTRQSPSSPRQQAVAPTLKSSDNRDIRPLKRAKDDFWLANAEVSPNAVVLVPAPNVNLNVNTPPFRSFFLNRILDGMKNKDASQGIKEPNALNYKVDEDNGEIKRIVINNYRDKDRLQEIFNTSTWVFTRMLEKSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFF6</accession>
    <name>K0IFF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16120"/>
    <dbReference type="EnsemblBacteria" id="AFU58545">
        <property type="protein sequence ID" value="AFU58545"/>
        <property type="gene ID" value="Ngar_c16120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16120"/>
    <dbReference type="HOGENOM" id="CLU_870458_0_0_2"/>
    <dbReference type="OMA" id="CFESERQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1610-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="321" mass="35878" checksum="D7E0E223A598200D" modified="2012-11-28" version="1">MLEKIAGTILESQPEHFLSLPLVSKNEESASLPLVINVVAKYWGENIAPQATAAETKGAAMIDGIMLAESRGFASYIYKGSTKDLKKRIDQGIPPIVIMPGIQGTVQHAMVVSGYNSEERRMLTYVPEPDTVGAIPEGKFEQDWEQDDMTVIIIVPSDMKDLLKNESLKFAKSNRICFEAEGLRQRGRVNDAIEKLQKATEIDIDNAQAWCLLAGMYNETNSEQAVPCYERAIRLNPKYYLAYRGLGNYYLKKKDYSLAEAYYSKAIGINPVRFGPIYKNRAIARIQLANNQGAKEDLVKYLEQTPAAEDKESIKQAIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFK7</accession>
    <name>K0IFK7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trpC</name>
        <name evidence="6" type="ordered locus">Ngar_c16620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16620"/>
    <dbReference type="EnsemblBacteria" id="AFU58595">
        <property type="protein sequence ID" value="AFU58595"/>
        <property type="gene ID" value="Ngar_c16620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1637"/>
    <dbReference type="HOGENOM" id="CLU_034247_0_1_2"/>
    <dbReference type="OMA" id="REIVWQK"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGPS" evidence="5">
        <location>
            <begin position="34"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="269" mass="29196" checksum="81F82686F6F560CC" modified="2012-11-28" version="1">MMSKFVRTGLGIKRLVDNSFKAIDEGAYDTTAYSLTHDAISLRKAITLCLHAPLISEVKFSSPSQGRIRSKTTSSLVEIATTMIKSGAIGLSVLTQPYLFEGSIEYLTAIRKAVSAPLLMKDIIVSTIQIDAGKKAGADCILLIKTIFDQDLAEESMEKLAEYATNKGLQVLVEVHTEQEFGEVLNAKYPLIGINNRNLDNLQVDIATTERLLKNHDKGKSLIISESGIAKPADIQYLRKAGADAFLVGTSIMETGDIGAKVAELYNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFL7</accession>
    <name>K0IFL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57623">
        <property type="protein sequence ID" value="AFU57623"/>
        <property type="gene ID" value="Ngar_c06800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06800"/>
    <dbReference type="HOGENOM" id="CLU_2875212_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-678-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8426" checksum="E0366DD536D3634C" modified="2012-11-28" version="1">MYNNVFMMHSYTNIHRAIKEMKRLQITLEDELYQWVTKEIEKLRFGSYSHAINFALKQLKESETAKDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG55</accession>
    <name>K0IG55_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58770">
        <property type="protein sequence ID" value="AFU58770"/>
        <property type="gene ID" value="Ngar_c18370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18370"/>
    <dbReference type="HOGENOM" id="CLU_175994_0_0_2"/>
    <dbReference type="OMA" id="HICQCIV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1835-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8704" checksum="FEBFD740DAA92253" modified="2012-11-28" version="1">MAQTDVQKCPVCSGKGLIEITDSDCPFCNGTGEFTKAAESYMKSHICQCVFLDRKNCPLCGKKCHHNTPNRPKILIAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG95</accession>
    <name>K0IG95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.14" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09010"/>
    <dbReference type="EnsemblBacteria" id="AFU57843">
        <property type="protein sequence ID" value="AFU57843"/>
        <property type="gene ID" value="Ngar_c09010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09010"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.859"/>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_2"/>
    <dbReference type="OMA" id="EPLGFHD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-899-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="374" mass="42032" checksum="0F3DB4BD4F7F4C1C" modified="2012-11-28" version="1">MYLKVLTKDELTDKIGIIVGTRPGIIKFSPIIRAFIEKKIEPLIIHTGQHYSYGLDRIFFEELDLPVPSHRVPEMEKTFYHGEQTAHMLVGIERVLLKEKPRAVIVGGDANTNLAGALAIRKLGINLVHLEAGLRSNDWRMPEEHNRVIIDHISDILLAPTSEAVNNLKTDGVKGKIFLVGNTISDAVNQNKIIAESKSKILETLNINKKKYLLCTIHREENVDNKMITSALCNAIEELAVRFDIPIIFPIHPRTDNRLKSFGISFKNERIKLIPPVGYFDFLKLLSNCSVVLTDSGGIQEEACILGIPCITLRDNTERPETVTIGANKIVGHDKARILQEVEYALNRKASWKNPYGSEVGRTITRIMQTEFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGC7</accession>
    <name>K0IGC7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60456">
        <property type="protein sequence ID" value="AFU60456"/>
        <property type="gene ID" value="Ngar_c35430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35430"/>
    <dbReference type="HOGENOM" id="CLU_2679068_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3544-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8445" checksum="5209980CC8629F39" modified="2012-11-28" version="1">MSGGIIGEEWKGKADVFVDRLIVMGVGHYIVIIAGVIAVCIFYRKDEQLPETRTSSYLFFFWKRNVLTVDKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGH9</accession>
    <name>K0IGH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c19780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58910">
        <property type="protein sequence ID" value="AFU58910"/>
        <property type="gene ID" value="Ngar_c19780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1958"/>
    <dbReference type="HOGENOM" id="CLU_000288_47_1_2"/>
    <dbReference type="OMA" id="EYHDILY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1976-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="52"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="247" mass="26587" checksum="99C79FF77AA60C5D" modified="2012-11-28" version="1">MSYRRSQNTATKKVIIAAAGGVAALAMLTVVFMYSNSSESKQTTGYSEVQGLSIATSTDKSALSTSNIKGEGSPLLGNPSAPITLVEFGDFQCPNCGRFARVTEPQIKEAYIDTGKINMVFRHFPVIGPDSVTAAMASQCANEQGKFWEFHDALYNNQGAENSGWANANNMKAFASKIGLDREKFDSCLDGGKYKGFVESDFNFARDYGLRGTPSFLIINGDGSNPEVLTGAYPFATFKATIDKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGI3</accession>
    <name>K0IGI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major intrinsic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c35830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35830"/>
    <dbReference type="EnsemblBacteria" id="AFU60496">
        <property type="protein sequence ID" value="AFU60496"/>
        <property type="gene ID" value="Ngar_c35830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3590"/>
    <dbReference type="HOGENOM" id="CLU_020019_3_1_2"/>
    <dbReference type="OMA" id="WTPGPLH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3584-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="23426" checksum="2DFA887FEA5FE8D3" modified="2012-11-28" version="1">MQRTSSRLTSSQKIFFVELAGTFVVVLLATGSVVIDAKVGGALGLPFVAFAPFAGVAAMVYAFGKISMAHFNPAVTIGFFVSGHIKKTQLSVYLGAEIIGALLASLSVLAFIGSEANLGANAPNYSFPLAVIFGVEVLVTGFLMAVIFAAVYTKGLRGWSGIAIGGMVGLDIFFFSFISGASMNPARSLAPALLSGAVSDLWLYWSATFAGSAIVALLCRKKFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGI8</accession>
    <name>K0IGI8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GCN5-like N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58920">
        <property type="protein sequence ID" value="AFU58920"/>
        <property type="gene ID" value="Ngar_c19880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19880"/>
    <dbReference type="HOGENOM" id="CLU_1544139_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1986-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="19505" checksum="44E5DB9B05359504" modified="2012-11-28" version="1">MINPDDLDFSHFTPKDDFSNNDFTEDDGSDPLGVDEFIRKKARLYEDSNLSRVYTVRYDGKVVAFCAVSMSAIEVKKLADGHAVEGATTKYYPAMLLGQMGVDKKYRNKRIGLSICKYCLGLAIEVGQKVGCAVLCLETNREKAGYYKKWGFVHAGRESTGSKVWMYVRTAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGK6</accession>
    <name>K0IGK6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW</name>
        <name evidence="2" type="ordered locus">Ngar_c10210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10210"/>
    <dbReference type="EnsemblBacteria" id="AFU57963">
        <property type="protein sequence ID" value="AFU57963"/>
        <property type="gene ID" value="Ngar_c10210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.972"/>
    <dbReference type="HOGENOM" id="CLU_048995_3_0_2"/>
    <dbReference type="OMA" id="FIQGVCH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="20358" checksum="106E0976CEB4D9D5" modified="2012-11-28" version="1">MSAKDQAGINPHSKIVVFSLSDANTKKKTDYGVSVEQVQEIGTLEDVTRVPGAPTHVKGVMNLRGKIITIIDMRKMLGISSDAASGTSGTSDRIIVAQIGQSIIGLLVDEVDQVIEISAGDIEPVPSVLSETAPYIKGIAKLKGDLYVLLDLRLLFANEGPLEDHVPTSGNGKSLDDIPTLSGQKKIVEANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGP3</accession>
    <name>K0IGP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00320"/>
    <dbReference type="EnsemblBacteria" id="AFU56982">
        <property type="protein sequence ID" value="AFU56982"/>
        <property type="gene ID" value="Ngar_c00320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.36"/>
    <dbReference type="HOGENOM" id="CLU_004253_10_0_2"/>
    <dbReference type="OMA" id="KWEVLPA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-32-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="340" mass="36091" checksum="649252D07193E96D" modified="2012-11-28" version="1">MAARTYAIIIGAGIATAAAAIAIAFAIFISPALTVSPTPAAPSPAWSEGEPMPTPRTEIAGAAVDGKIYIIGGFDRFGRAVSTVEVYDPENDQWNTSAPLPQPLHHAAAASYNGTLYVVGGYLEDNTPSNKLLAYDPETNEWQELAPMPTARGALTANFVNGILYALGGVNSSFGSPAAPLATNEAYDPETDSWTQKAPMPTPRQHLASVVLDRLYVIGGRIDSLSSNLDAHEAYDDQNDNWIKLSPMPSKRGGLAAAPSYADDHIYVFGGESPTGTFNNNERYNPLNDSWSSATPMPDPRHGLAAVTVDNKIYVIGGGPQPGLTVSGTNQIYPTYYPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS6</accession>
    <name>K0IGS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57027">
        <property type="protein sequence ID" value="AFU57027"/>
        <property type="gene ID" value="Ngar_c00770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.79"/>
    <dbReference type="HOGENOM" id="CLU_270603_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-77-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1151" mass="120181" checksum="FF24A815F56EA67A" modified="2012-11-28" version="1">MYVKVDNLGNPANTLGSAEDPQTPATPFSSTNTRLYIGTGGSGDNSAYPNTSGSAPNQTVERTISLNSVSGLEGGQITFSFGGVQKTVTWDDSTASVSLDRTNYGPGATAYVVVEDQDMNLDPTAVNTFSDTASAPANQNLTNGVDKGSSLTYTETGANTGKFEITYTIGILTTGTSQGRSLTVNDFKNFTASGTTIALGSGTGGSGSPIGSSSASYTVQRVSGGLGAVSSVTYAGELPLTVSDSDRNLNSKAQESLNTKLQVNEPSQTNKREFNLREQSQSSNTFVPAYGQDRIILTWKQNTTEAQGILKLLPGQEATIRYEDDVPSTGGPANTSSITIKPTNTAPTLSADKTTVGRSSVIGLTMNDPELNDDSQIVESYTVTFTGTTAATNVPAFPSTISPFSLKIDKNGAAMTISPNFSVTFTETGPNTGVFTAEVDLSDLAASPALADGDTLKIEVNDILEPGESETADVSLTVGLEKPTVKVDRSTVPVPRLATADDFVTHGIASNSTGSARDNIANTGPVDIVITITDPNRNNSTINEETLGSGTAFTTVTGGNVARQVFSYDGGRLVLTLDAAPGQLFANTAGITMTDALKETGFNTGIFQGTIRVDPSVAGNDDPLWIGAKLKIEYKGLSVASSTDDANAVTVTFTARQAVLSTDTSTVVNGGEVTFTVTDQDSNRDPDTAEKVKIRVAWTGANGNAQNRWLELEETGKDTGVFTETIAVGDDTIDGITFDVESDSEVDVFYYDATPSVSASTNWPALGSTNGRHEKTLQVGAASGSLDLGITGTSVGPSSEIDVTIFDTDVNTNPNTKQIIGQGTGSLITVATDAGIEVQLDAEETTGSSARFVGTIKLQADATPTQAEVAGDDSTEVTIPVSPGDVVSVRYEDQNDENGRRTTISKQFTVVSVDPEITTDKNVYAAGDQMKITLADLDRDRDPDSNDIVNVKATSTSDLVGLSSVQLIETGPNTGVFEGTLTLSAQFSSGSLTVKNGDVITIKYTDDFPADYEERVDAGGTTSKDFVKTVPVGTSGTTKTTTPSKPELKDAQGRPVTQVLAGQQVVLSTTVKNNEAASTPYAAIVEVRDSKGITVFLNWQTGTLQADGTTGIGLSWTPETPGTYTARVFVLSGLTNPQILSETITSTITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW3</accession>
    <name>K0IGW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21650"/>
    <dbReference type="EnsemblBacteria" id="AFU59095">
        <property type="protein sequence ID" value="AFU59095"/>
        <property type="gene ID" value="Ngar_c21650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21650"/>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OMA" id="QICSHYF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2163-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="1">
        <location>
            <begin position="183"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="345" mass="37071" checksum="FCEC8982DBDCE264" modified="2012-11-28" version="1">MAGDIMVAVIGVGNVGATFVQGVDYYSNGKNTIGLWHQKVAGLKPSNVKVVAAFDIDPAKVGKNLSQVAVESTRKYHDIKDLKITISPGILADSSNDKIERPVKTSPDEFAKELKKSGAQVALNLISSGMDKTSLEYAKAALAARVSFVNATPAKIATNPALAKKFASSRLVLAGDDLLSQFGGTAFHKGMIDFMVERGVHIKKSYQLDVGGSAETKNTMDERIRMLKRGMKTGSIGMEAPYKFESVAGTTEYTDFLGDSRNSYYWMSSEGFLGSSIVMDLTLRTSDGANAGNVLLDVVRAATTAKKAKVSKASEVISAYGFKNPPKQFKIREAYANFVSMFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH30</accession>
    <name>K0IH30_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57122">
        <property type="protein sequence ID" value="AFU57122"/>
        <property type="gene ID" value="Ngar_c01730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01730"/>
    <dbReference type="HOGENOM" id="CLU_1412403_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-173-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="22072" checksum="B2C6CF7FAF95AA52" modified="2012-11-28" version="1">MSFLDRIRRRKSKDEVFQGKNEEGQVERQQQVSGRSESMREERSNEPVRCETCGTDFSSPQDFERHAKEDHPDIPAKPRRGRILMYSSMDDLVRTAIMSKNVIEFSYHGYHRIAEPHVFGIHNGRKQLLVYQTGGQSSSGKIPGWRRVNVDEITSARITAQTFVGQRPFPSGEHSNFDTIIAVVTYRDEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH53</accession>
    <name>K0IH53_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59200">
        <property type="protein sequence ID" value="AFU59200"/>
        <property type="gene ID" value="Ngar_c22700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22700"/>
    <dbReference type="HOGENOM" id="CLU_3021092_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2268-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6176" checksum="EE8FC5F9E3AE0B35" modified="2012-11-28" version="1">MPFEPKVKLGKVGNSFKVTIPSEMIQDLGWKEGDFLRIGLDDNSLTIRKEIAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH63</accession>
    <name>K0IH63_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-alkenal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12330"/>
    <dbReference type="EnsemblBacteria" id="AFU58173">
        <property type="protein sequence ID" value="AFU58173"/>
        <property type="gene ID" value="Ngar_c12330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1183"/>
    <dbReference type="HOGENOM" id="CLU_020120_2_0_2"/>
    <dbReference type="OMA" id="SSYPEQD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1231-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="283"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="400" mass="42201" checksum="7108DCCE4FA4F4B0" modified="2012-11-28" version="1">MNKAILAASIVVAAVAIFFVYSQFIDLDFGDGGVPIIKDFVQVSENGKGRADLDDSAFQIGQVSTVQASSSELSLPDLFAKVEKSVVQITDSDETNPLDSRLGSGFVYDTNGHIITNYHVVNGGGRLDVTFLDGTVYRATLIGSDPFTDLAVLYVEDVPREKLVPLPLGNSSNIRVGEQVAAIGNPFGLSGSMSAGIVSGVGRLIPTQEAGGFSIPDVIQTDAPINPGNSGGPLLNMRGEVIGINSAIFSTTGQFAGVGFAIPSDTMTKVVPSLITTGSFKHPWLGVSGRDMTPGIADRLNLEEPRGFLVMEVVAGSPAEQAGIRGGNQEVVIDGVPVMLGGDVIISIDDRTVRKIDDILVYLQRDKEVGDELKLTILRDGREMNVTAVLAARPSQQESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH67</accession>
    <name>K0IH67_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="7" type="ordered locus">Ngar_c01980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01980"/>
    <dbReference type="EnsemblBacteria" id="AFU57147">
        <property type="protein sequence ID" value="AFU57147"/>
        <property type="gene ID" value="Ngar_c01980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01980"/>
    <dbReference type="HOGENOM" id="CLU_056222_2_0_2"/>
    <dbReference type="OMA" id="KSQFQGY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24573" checksum="C8A3A0AACE4B4B71" modified="2012-11-28" version="1">MTVKVSDQNIAAQVLKPTPTGDIVIASAHSRELEKQGWKGALNNLPACYLTGMLMAKKALEKGVKNAVLYVGKDHFTSRVAACMKGIVDGGVSMPVSEESLPDEERITGQHIAEYASTLKENQEEYNSRFSAILKNGLNPEDYPLHFEEIKSKLSGKPAPKRVAKEEEEGEEAPTAAPKEKKEAPEKEEKKAPKEKKETKKKEAKEEKGKEKKAKEGGKTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA1</accession>
    <name>K0IHA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58248">
        <property type="protein sequence ID" value="AFU58248"/>
        <property type="gene ID" value="Ngar_c13100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13100"/>
    <dbReference type="HOGENOM" id="CLU_2079493_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1308-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12200" checksum="98077A682B869631" modified="2012-11-28" version="1">MKHARTSILQRFKPRLAVAGSGLAAGAISSLAISALILLVEKIADLPVGTFYLVLVSALLQMQEHTVTTVALGFLLHLAAGSVMGVVISVPFCVSKRSFVSSGRYAPVYGLAAGFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE1</accession>
    <name>K0IHE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59350">
        <property type="protein sequence ID" value="AFU59350"/>
        <property type="gene ID" value="Ngar_c24260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24260"/>
    <dbReference type="HOGENOM" id="CLU_2490609_0_0_2"/>
    <dbReference type="OMA" id="HYQTRRA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2424-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10502" checksum="0EED64C895001FAE" modified="2012-11-28" version="1">MDARVKKAVLSKIDETVSNIDEISKIRHSLAHIPVGSQDDFAFGIAIGRIYNSFHYQTRRALKRNATEEEFAEFLEILSKQAGNIRKVLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE6</accession>
    <name>K0IHE6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59355">
        <property type="protein sequence ID" value="AFU59355"/>
        <property type="gene ID" value="Ngar_c24310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24310"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2401"/>
    <dbReference type="HOGENOM" id="CLU_3130973_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2429-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5642" checksum="A245CD42810CEAB9" modified="2012-11-28" version="1">MNIIERLRRKQIYHNVQRNVLTILLICAAMTGATVSIFILLDILLGFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHG5</accession>
    <name>K0IHG5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14070"/>
    <dbReference type="EnsemblBacteria" id="AFU58343">
        <property type="protein sequence ID" value="AFU58343"/>
        <property type="gene ID" value="Ngar_c14070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1370"/>
    <dbReference type="HOGENOM" id="CLU_149791_1_1_2"/>
    <dbReference type="OMA" id="MSVGLYA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1405-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12542" checksum="022E9985A00D794C" modified="2012-11-28" version="1">MTEEKVFELEDLVAQLEKEGGYFLDFLKIRNLEAGIIVLHPGEKDTQEPHSADELYYVIEGSGFMELGRSKWQPVKKGSIIFVPAGMHHRFYGNTEDLVVLYMFAEESTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHH0</accession>
    <name>K0IHH0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58353">
        <property type="protein sequence ID" value="AFU58353"/>
        <property type="gene ID" value="Ngar_c14170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14170"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1384"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OMA" id="ICEKGEN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1415-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9589" checksum="00F3503E208BBBEB" modified="2012-11-28" version="1">MKYRSRTDIVATILDAANGGSTKTKIMYKAYLSYAQLKEYLTILIENGLLEYEEGQLKYKTTEKGLRFMRTYNEIGEMVSTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ3</accession>
    <name>K0IHQ3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MTNA-like protein</fullName>
            <shortName evidence="2">aMTNA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnA</name>
        <name evidence="3" type="ordered locus">Ngar_c25430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25430"/>
    <dbReference type="EnsemblBacteria" id="AFU59465">
        <property type="protein sequence ID" value="AFU59465"/>
        <property type="gene ID" value="Ngar_c25430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2520"/>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_2"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="347" mass="37880" checksum="301D3C7A908B350D" modified="2012-11-28" version="1">MPRNLDLLLTVAWENNSVVLIDQTKLPNKLVYVKCKDYREVAEAIKKLVVRGAPAIGVTAAFGLALAAQQSKAKTLPELMTDLDTAFKVLRATRPTAVNLFWALERVMGRAKKAKTLQEAKKAVFDEALKMSDEDINANRQMGANGAKLFRDGDIVLTHCNAGSLATVAYGTALGVIRAARESGKRLSVIATETRPVMQGSRLTAFELQHDGIDVSLIPDTAVGHMMARGAIRRVIVGADRVLRTGHVFNKIGTYQVAILANKHKIPFYVAAPLSTFDFESNPEDVVIEERSVDEVVRVGKKRVAPKGVRVFNPAFDMTPPELITGIITERGVLTPPFEKNLKALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0II17</accession>
    <name>K0II17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58578">
        <property type="protein sequence ID" value="AFU58578"/>
        <property type="gene ID" value="Ngar_c16450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16450"/>
    <dbReference type="HOGENOM" id="CLU_069867_4_0_2"/>
    <dbReference type="OMA" id="RYPEWNP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1643-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16812" checksum="E97A41D71C343552" modified="2012-11-28" version="1">MKELHTEIEISASPEKVWKILTDFERYEQWNPFIHKIIGEAKEGSRIEIHIETPRGKRRKYEPTVTKVEHGRELRWLGKSSLPGILNGEHIFTIEQLQPGSVRLVHREVFDGLLTSFFGKSLDTDVKEGFEEMNKALKERAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II39</accession>
    <name>K0II39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58608">
        <property type="protein sequence ID" value="AFU58608"/>
        <property type="gene ID" value="Ngar_c16750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16750"/>
    <dbReference type="HOGENOM" id="CLU_2985801_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1673-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6773" checksum="4752D631C6E9C7B4" modified="2012-11-28" version="1">MDFLRQRLKRAEEKDLGSCGALMRRAGFEKVEREEEVFGDGQRIYILYKFAEIVMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB5</accession>
    <name>K0IIB5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SNF7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58693">
        <property type="protein sequence ID" value="AFU58693"/>
        <property type="gene ID" value="Ngar_c17600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17600"/>
    <dbReference type="HOGENOM" id="CLU_095961_1_0_2"/>
    <dbReference type="OMA" id="RKMIKII"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1758-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="23744" checksum="A375BD272173B773" modified="2012-11-28" version="1">MPFDSKWVKPQGESVGHRLLEGIKPQAPLKPRIEEAQKKLQMQIAKLDSISARMQEKDHVIFKRVVLAMQSHDASHARVLSGELAQIRKMNKMVTSAKLALEQIQLRLNTITELGDVVVTLSPAMSVIKGLQGGLAGMMPEADQSFGQISELLGNIITDSGQIPNNEIGTVTGFNEDTARIMEEASAVVEMNMKNKFPDLPSSTTSSMTKNLEATGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB6</accession>
    <name>K0IIB6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57762">
        <property type="protein sequence ID" value="AFU57762"/>
        <property type="gene ID" value="Ngar_c08200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08200"/>
    <dbReference type="HOGENOM" id="CLU_2730538_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-818-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIB-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8440" checksum="BF14C0B6C18A6C59" modified="2012-11-28" version="1">MASFCPECGGELKFDLTSKNFICKSCGLFASREKIDELRDKAERSRDDPRRKHHDDYLDWWQSSKKDKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC0</accession>
    <name>K0IIC0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58708">
        <property type="protein sequence ID" value="AFU58708"/>
        <property type="gene ID" value="Ngar_c17750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17750"/>
    <dbReference type="HOGENOM" id="CLU_1922677_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1773-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17556" checksum="6FB9EC37C8777A36" modified="2012-11-28" version="1">MASPPFVDGKVREGIIYRLKKAPESPVKYPYLIVSDNLDAPAADVLMISDICNIYRAKEKLKKKVKKGTGLEVAVAPARKMDAAGVGRWFEGIRELYLFCQSSRCQFILSSGAASMHEMVSGPCLDAVLKNCDIDPQRHWHEMNSWLEAKLSRRVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ8</accession>
    <name>K0IIQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20260"/>
    <dbReference type="EnsemblBacteria" id="AFU58958">
        <property type="protein sequence ID" value="AFU58958"/>
        <property type="gene ID" value="Ngar_c20260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20260"/>
    <dbReference type="HOGENOM" id="CLU_1040582_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2024-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="29719" checksum="C949777A2EB6AAEB" modified="2012-11-28" version="1">MQLAETERPIFDIVPHIFKRPLLSASPSDPLLQVATFLAIGPQIYVDGVVVLDNHKVVGAIGGRHIIEHILYHPKGWLQGTASMVMSRFEHAVQVDYPLSVALDIFSKTGFAFVPITVKQSVVTSLSIRDVLRVAMASKLDTPIDRLSSPLVAVKSNTSIGDALEIMLEQGIRNLIVKDNNSNTGVLNDRKMLEYLLSYGGRETVLSRGLDGLFETQVNILDLAAAKSVNRDTPAGLAAELLLDLNAPCLLLDNGSIVTPWDVVMKGLRKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR4</accession>
    <name>K0IIR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sugar-phosphate nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10550"/>
    <dbReference type="EnsemblBacteria" id="AFU57997">
        <property type="protein sequence ID" value="AFU57997"/>
        <property type="gene ID" value="Ngar_c10550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10550"/>
    <dbReference type="HOGENOM" id="CLU_938812_0_0_2"/>
    <dbReference type="OMA" id="NATICRS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1053-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="296" mass="31894" checksum="FF7CBFF1FFAA3324" modified="2012-11-28" version="1">MCGSFDLIIVFKEAPHHLSKMTTQDACSFSVMGKPLVLYNIAKLASRKSIDGVLFPEGYTHVANVISASYPSMRVDEYKDKAFISATGDLLELPLNSIIVESSMGDLVADQMMYPWDLLRIMNKVLESEVKTTLISPNATICRSSIISGPCIIEDGTFIDDFCKIKGPIYIGKNSKVGTGSLLRNCMVGSESSIGFNCEIGRSYLAGKNKIAHHNVILDSIIGEGTWMGGYVGTTNVLLNSKNVKYKVGDQLIDTGLHHFGAVIGTNCMIGAGVIVLPGRYIPSNSAIQAGTIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS3</accession>
    <name>K0IIS3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS and zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c20410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58973">
        <property type="protein sequence ID" value="AFU58973"/>
        <property type="gene ID" value="Ngar_c20410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20410"/>
    <dbReference type="HOGENOM" id="CLU_1003320_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2039-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="173"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="30618" checksum="287D999EBE67A684" modified="2012-11-28" version="1">MSLSVIMPTGLFGSAFFTITTLPMLLSAMILATALTVWLSLAVFTSLTMTLETVIDSMLMLDCSASWYFTSRNVVHCTANIHNISPGRQSRPMYQEYADKKAGDIAERDILVMDESAYVADAARAMRQKGVSSVLVSRKAAMEPIGIITERDILYRLVAEHRSPFKTVLKDVMSSPLIVVDESATVKDAIVLMRKNGIRRMPVTKEGKVVGMLTLKSVVGDSREKSIELIDVELPATISKVACPYCGSRFENKQDLSKHIDRLHLGSGLLEGDLRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS7</accession>
    <name>K0IIS7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58978">
        <property type="protein sequence ID" value="AFU58978"/>
        <property type="gene ID" value="Ngar_c20460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20460"/>
    <dbReference type="HOGENOM" id="CLU_1529280_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2044-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="20055" checksum="E2EB04C3BFDFD474" modified="2012-11-28" version="1">MQCIAIHSWLINRCTTVIALQALNNVVIKYYRCFACNLTFKILASAIEHKTATLHDDIKEEYFLSRFEPFPPIQLSKPADSLPEILPFEDIAIGEPVEPVEKREFYVCLSCRLTFKDRRAAAEHKANSGHKVVRENYPIGPSYPANFEKLSDVRGSNIDYDAFFQRTIDDVPNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX2</accession>
    <name>K0IIX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BNR/Asp-box repeats-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58077">
        <property type="protein sequence ID" value="AFU58077"/>
        <property type="gene ID" value="Ngar_c11360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11360"/>
    <dbReference type="HOGENOM" id="CLU_559765_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1134-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="393" mass="42447" checksum="3155FCE4A6AB49AE" modified="2012-11-28" version="1">MAFALALFVYQPQPQHDIVSGMIEDDDNGSLPVVFENATNLTNNEQDSVYGQVAAWNNSVYVIWQDSVSGRNYDIFIKKSNDNGTSFGTPVNISDNLGFSEHPQLSVYESNVYAVWADNTPGNREVLFARSTDGGASFEETRNISNNALDSYNQEMAASGDNVYLAWVDLDEQENASIMFRASADGGATFGETVNIASSGQASFSSFPKVAAYGNDVYVTWNVMEGGDEDGLYFAKSSDRGSTFGEAVRFRSDISGESQVAAYNGTVYIISGGLDLKEVNGLYFIKSTDGSETFADPVMIDADGKFINPLNVELVSDGNDSVYVAGQVFSGGNEEILLMQISSNNATGVVNLSKNEKISECPSIAMAGDNIYVVWEDLTPGNHEVLYAKGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ58</accession>
    <name>K0IJ58_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58227">
        <property type="protein sequence ID" value="AFU58227"/>
        <property type="gene ID" value="Ngar_c12870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12870"/>
    <dbReference type="HOGENOM" id="CLU_184935_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1285-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="9747" checksum="9C1C440739E6ED28" modified="2012-11-28" version="1">MAHHEAESGGYGSSPHMKTVAWSILVMGISLAIIIILYIWIGWIPGSGFSDDIMREQQDALRVEYGLPPVEEITPEEAEIPPSLRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ66</accession>
    <name>K0IJ66_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58252">
        <property type="protein sequence ID" value="AFU58252"/>
        <property type="gene ID" value="Ngar_c13140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13140"/>
    <dbReference type="HOGENOM" id="CLU_1092454_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1312-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="254" mass="28775" checksum="DC82524498A61364" modified="2012-11-28" version="1">MEAGSSAPQRSRKSHGKAYLWFQRNEQRLLVIDVVCIVTLFFLHLFTSMFQIFVHEIAIAVQIAATVLAAFIALSVVWKGIVPLVICILGIVLMHNSVILPYYAEPQPGEATVGGARFTWTLYTPLAVSVAANMHFFLGVAMVAFSIIIAYRPSILFARNRPEPLDSEWSKYPVWYDNTLLANNLTEPSIPVQNLMTDQDRYLLWRYEYVLADIYGTPHLVRPNGMVPKNSTHIFRDKDSGRVIGKARYTGFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ75</accession>
    <name>K0IJ75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c13390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13390"/>
    <dbReference type="EnsemblBacteria" id="AFU58277">
        <property type="protein sequence ID" value="AFU58277"/>
        <property type="gene ID" value="Ngar_c13390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13390"/>
    <dbReference type="HOGENOM" id="CLU_1682752_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1337-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="60"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="16534" checksum="FDA893972CB47E24" modified="2012-11-28" version="1">MISIIVHNPVNTFISFGLLIAIVGGSFYYVYALAPRGPWMGIMDGAFITPGAAQAIGLDEDHGFLIFVIAPSSPAAKVGLQQADDEVVIGGQRIPVGGDIIVSMDGRQINGIDDICSVLEQKQVGDNVRIGINRDGRLQEVNLILEEAPPGETSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA8</accession>
    <name>K0IJA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59183">
        <property type="protein sequence ID" value="AFU59183"/>
        <property type="gene ID" value="Ngar_c22530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22530"/>
    <dbReference type="HOGENOM" id="CLU_3163252_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2251-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="47" mass="5193" checksum="759FAE68E22EC050" modified="2012-11-28" version="1">MCDKGFEGLVIGFAVSGDLCSRALRNFWYGVSPSIVVVKLNDYSFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC4</accession>
    <name>K0IJC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59213">
        <property type="protein sequence ID" value="AFU59213"/>
        <property type="gene ID" value="Ngar_c22850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22850"/>
    <dbReference type="HOGENOM" id="CLU_2177961_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2283-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12762" checksum="93100D7573AC192C" modified="2012-11-28" version="1">MARTISSRAVAQILDFFLDHKEFDYSPAEIAKKTGLSFRTIFRELPMLEKYQLIYNSRKIGKTNMYRLNTDFRAVSLLEQFTLEMAQVKVDHHNDSKGKTEINTNIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF0</accession>
    <name>K0IJF0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59268">
        <property type="protein sequence ID" value="AFU59268"/>
        <property type="gene ID" value="Ngar_c23420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23420"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OMA" id="INFKMAQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2340-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9689" checksum="C310466876C15149" modified="2012-11-28" version="1">MKYRSRTDIVSQILEAANGGATKTKIMYKAYLSYAQLKEYLAVLVENGLLEFEKGTQTYKTTSKGLQFLKTYSQIGGLIIPDTGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH1</accession>
    <name>K0IJH1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58417">
        <property type="protein sequence ID" value="AFU58417"/>
        <property type="gene ID" value="Ngar_c14810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14810"/>
    <dbReference type="HOGENOM" id="CLU_2911651_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1479-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6997" checksum="DC25EBA47C86D69C" modified="2012-11-28" version="1">MLVQKKKVAQKKNVRYVCKRCNMLFFSHPDVIEHKAMTDTGNTKKASASSEISARAKNQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI2</accession>
    <name>K0IJI2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA</name>
        <name evidence="9" type="ordered locus">Ngar_c24130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24130"/>
    <dbReference type="EnsemblBacteria" id="AFU59338">
        <property type="protein sequence ID" value="AFU59338"/>
        <property type="gene ID" value="Ngar_c24130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2385"/>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_2"/>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="100"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23627" checksum="7D264CD8977A3C3E" modified="2012-11-28" version="1">MANFTLPPLPYSYDALEPHIDARTMEIHHTKHHQAYTDGLNKALSSLGPEWQNKNDVVDILKNIDSVPESARGAVNFHGGGYNNHTLFWNNMKKGGGGEPSGELADAIKKAFGSFNDFKTKFQTDTVAIQGSGWGWLVKNASGGVQFITMPNQTSPWTRWNKEKLTPLLGLDVWEHAYYLKYQNKRADYVTAWWNVVNWDEVAKRFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ1</accession>
    <name>K0IJJ1_NITGG</name>
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        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24340"/>
    <dbReference type="EnsemblBacteria" id="AFU59358">
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        <property type="gene ID" value="Ngar_c24340"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_044208_1_2_2"/>
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    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="224" mass="23975" checksum="7934671CA40E0E01" modified="2012-11-28" version="1">MRAVVIVVLASAGLLGSVLDAITGMIVEYGYPAVFAAAFIEVMFPPIPSEVIFPLVGFVAQSSGFGLGNAIGMAATGALGSTAGAILIYFVSMKVGRAAIVRFGRRVRVSEREIEKAERWFARYGPIAVFTGRMVPGVREIISIPAGIGRMNFVKFVTYTFAGSLVWCVVLTLVGYYLGEAWSRFSEQISSTFTIVSVIVIAGIVAGIAVWYDRRKKAPAKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK1</accession>
    <name>K0IJK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59373">
        <property type="protein sequence ID" value="AFU59373"/>
        <property type="gene ID" value="Ngar_c24490"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_080344_1_0_2"/>
    <dbReference type="OMA" id="IRLQPNY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2447-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="254" mass="26680" checksum="98A7AF364FA817BF" modified="2012-11-28" version="1">MNSKFLILPLVALTVIAMMASAVSAQVSPSYDPAQSTSAIPDANNTIVVTGTATERVKPDRVTAAFAVETVDETAGAALKKNSEKMDSVIAALENAGVQENETRTAYFSISPNYNYTEFGAQELTGYTVTNSIMVESSNLSNVSEWIDAAVRASANRVDSLSFTISEEKLDNIRADLTQQAVDNARDKAEALARALDVEITGVKAASLFDLGNPPVTPLSLSLATDAAAKSVATPIIPGEQTVTATVAVVYEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJP9</accession>
    <name>K0IJP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">K+ transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c33750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60290">
        <property type="protein sequence ID" value="AFU60290"/>
        <property type="gene ID" value="Ngar_c33750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33750"/>
    <dbReference type="HOGENOM" id="CLU_2313880_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3375-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="10839" checksum="D239F6566FA1CCAF" modified="2012-11-28" version="1">MQVIREVLGIKLVREILIVIGLYIGISTLTRSALSYTMGRSLDDGMFEAVSALSTTGMSTGITSLALDSSSKLMLIANMILGRFEIISVLYIFFSSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT1</accession>
    <name>K0IJT1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60345">
        <property type="protein sequence ID" value="AFU60345"/>
        <property type="gene ID" value="Ngar_c34300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34300"/>
    <dbReference type="HOGENOM" id="CLU_137737_0_0_2"/>
    <dbReference type="OMA" id="IPFPNFA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3431-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="154" mass="17871" checksum="4C4A61A4C303440A" modified="2012-11-28" version="1">MSSTNNNVASNIIQILANLPDFLRKPMLQNRLKEFYAMSDEDRRETITMALSGAPMIDPNKLSVLFRTWLEVLSEFDAEKRVIMFQTYCRQILANARQIEKLDFKLLTATFLSLDQKQRERLTDSLQEVLFSFPNRNEILKLVPEDSLKAIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJW6</accession>
    <name>K0IJW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59518">
        <property type="protein sequence ID" value="AFU59518"/>
        <property type="gene ID" value="Ngar_c25960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25960"/>
    <dbReference type="HOGENOM" id="CLU_176749_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2596-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12046" checksum="15DB6B77458CC4B6" modified="2012-11-28" version="1">MATLDQEFRKRAGETIENYLRILSGTFPNRQNLADTWRYEHEDDFMYGLVVGQLDGLIVGYFRGIYDRAPTDEESQEIKGIVQAYVQQIKALVDQLKAKRGTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKA3</accession>
    <name>K0IKA3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp20</name>
        <name evidence="4" type="ordered locus">Ngar_c18240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18240"/>
    <dbReference type="EnsemblBacteria" id="AFU58757">
        <property type="protein sequence ID" value="AFU58757"/>
        <property type="gene ID" value="Ngar_c18240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18240"/>
    <dbReference type="HOGENOM" id="CLU_046737_9_5_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15268" checksum="F33DB32D8CC75F37" modified="2012-11-28" version="1">MGIVEYTVRELFRELDKRTQEFYEYVMPAVDMYEDGNDLVVDVDLPGFRKEDISIRIVDGNILSIKATKKRAPPTAEEPLGPIHYRQRPVQIDKRIVLPISTRDAERVTGTAKYENGVVTLRIPIPKATVVPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKJ4</accession>
    <name>K0IKJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58977">
        <property type="protein sequence ID" value="AFU58977"/>
        <property type="gene ID" value="Ngar_c20450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20450"/>
    <dbReference type="HOGENOM" id="CLU_2230466_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2043-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12012" checksum="F02CC647E5FC5121" modified="2012-11-28" version="1">MNMVRAKKSYQRSSDSPENLVSPYEDISTRQFHITGETFPTLALGICDNCHWCYSCINARGVIKVCPVCGEEVSQIPMDIDEICLIEEDEKRGITLNFDRRLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP1</accession>
    <name>K0IKP1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59072">
        <property type="protein sequence ID" value="AFU59072"/>
        <property type="gene ID" value="Ngar_c21420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21420"/>
    <dbReference type="HOGENOM" id="CLU_1891502_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2140-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15356" checksum="DA266F7181AC3969" modified="2012-11-28" version="1">MTLPSGKEVSIPLVNNLTFNRWTGRHVYNTFGCKPIVEYDGSWMFAELAIMKMVVKAGWSARWVEVYYLKKKEPYYLVDWNDTPSGFHQISVPLDSPFHIDPMSKIDKNCAIVHAKTLANVKNPKKKTKPYSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT7</accession>
    <name>K0IKT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c30620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30620"/>
    <dbReference type="EnsemblBacteria" id="AFU59978">
        <property type="protein sequence ID" value="AFU59978"/>
        <property type="gene ID" value="Ngar_c30620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30620"/>
    <dbReference type="HOGENOM" id="CLU_064879_0_0_2"/>
    <dbReference type="OMA" id="DHGMNVL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3062-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="359" mass="39526" checksum="94D6E866FD29DC09" modified="2012-11-28" version="1">MVTDVFKLSSEDTVARALNMMADKSINQIPVVDDDGKYLGMIFAKQLLNSSAQPSSKVKSYIVNTSMVGPNQDVEKAAQLVIGSGNRALPVVENGRLVGIVSETDLVSTADFGHAIVDEVMSGAIVIEEETSLADAVSKMRRYNISRLPVINTKGVLRGMLSIIDVARIIATPRERTSKSAAISGGTAAIKDVKVRDIMRRTVSVEPGTKLNSLADHFKRNEEVVVAGDGRPMGIVTPKDALELVLPKKTSEPMIHMAHLEDGQDRTEIQEQLARFLKKIQGKLGDVRSVVVYADKHKTRKYSLRTRLITSRGVIDAKAVGYDPLSASKELIARLDRRIKSEHSQRVKYKQHRESARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL04</accession>
    <name>K0IL04_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60083">
        <property type="protein sequence ID" value="AFU60083"/>
        <property type="gene ID" value="Ngar_c31670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31670"/>
    <dbReference type="HOGENOM" id="CLU_1607076_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3167-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="19381" checksum="DFE94B2C70C30152" modified="2012-11-28" version="1">MGLEITPSLKDALRELYYKEGCDQKGWAYIALKDIDIKGNTLVFNKGVHRISIKLMDKIVTEVKELSRSVNGNFLFDYLACKTGQLSKYGDVMLANPDALCWVKIGNGAFSSDQIDVLDRIKLPLVVFRIKDVLAPPAKVEMRWDIRSGDEWLDELDDLRDQAESDDEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL36</accession>
    <name>K0IL36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59302">
        <property type="protein sequence ID" value="AFU59302"/>
        <property type="gene ID" value="Ngar_c23770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23770"/>
    <dbReference type="HOGENOM" id="CLU_2406450_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2375-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="9997" checksum="4E312EEC2A530BB5" modified="2012-11-28" version="1">MRRPVPIVDYNSPDSQKAIEILRGKSIEFVEYDISKFETSCCGELSITIAPSVFAPEGFFKGLEWVVQYASSERKGDLPLEESESVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA4</accession>
    <name>K0ILA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative phosphate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c24680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24680"/>
    <dbReference type="EnsemblBacteria" id="AFU59392">
        <property type="protein sequence ID" value="AFU59392"/>
        <property type="gene ID" value="Ngar_c24680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2443"/>
    <dbReference type="HOGENOM" id="CLU_1998815_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2466-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="13586" checksum="984881A90CDFC01E" modified="2012-11-28" version="1">MVVWPAIIKQTRAYWRAHWLCTCCWGLAGTFFGGWRIVKTMAFRLTSRRPYQGFCAETGGGAILTSMAWLGIPVNTTHAISGAIMGAGATKRLSAIRWSLGRRIVYAWIIMIPASAALAAATCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM6</accession>
    <name>K0ILM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c36000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60513">
        <property type="protein sequence ID" value="AFU60513"/>
        <property type="gene ID" value="Ngar_c36000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c36000"/>
    <dbReference type="HOGENOM" id="CLU_1357861_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3601-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="23603" checksum="859CF33E5A156557" modified="2012-11-28" version="1">MIVDLSYVLSFLITLLTSDIVISGALAFLAGMVSVMAYTRAKNALADRRYRADEAVVEAVVLEYTRRLRDYDRVIAELRAKVDIMEVKAQTIPQAVTTISHYQQASHQPQPHVAPASEPVTVTQHATATAVIVEKENNGTTDYILKLLAERPRTSREVQHAIGRTREHTARLMKKLHDSGLVSRDANAKPFRYNITDAGRERLKEKVAPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR3</accession>
    <name>K0ILR3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03110</name>
        <name evidence="2" type="ordered locus">Ngar_c03410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57259">
        <property type="protein sequence ID" value="AFU57259"/>
        <property type="gene ID" value="Ngar_c03110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57289">
        <property type="protein sequence ID" value="AFU57289"/>
        <property type="gene ID" value="Ngar_c03410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03110"/>
    <dbReference type="KEGG" id="nga:Ngar_c03410"/>
    <dbReference type="HOGENOM" id="CLU_1773256_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-311-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16650" checksum="D156C085BB942451" modified="2012-11-28" version="1">MDLKLPKQQILEYPWLPYRTRYFDVLYYPVANIAVRYGHSNNWLSGLFVIDSGADITTMNKIVAEMLGISDFESGERIELTAAGGSAIEARIHRVDIAFNGIVVPDVRIAFAKKNELKMSLLGRLDVFDYFDVNLQARTRRTILVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM31</accession>
    <name>K0IM31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59942">
        <property type="protein sequence ID" value="AFU59942"/>
        <property type="gene ID" value="Ngar_c30260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30260"/>
    <dbReference type="HOGENOM" id="CLU_2067883_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3026-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="11922" checksum="3F46963FE41AE3F8" modified="2012-11-28" version="1">MIRNTLTSTSLLGMVAAFGVMGIVPAAFAITPSSIVQDTINNNVQVSTQLNVQVNTPVAVSNNIAAGVAVATGSGSANLIQSISSSISQSATQNGANGNVQINVPTINQNIQFGNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM65</accession>
    <name>K0IM65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57599">
        <property type="protein sequence ID" value="AFU57599"/>
        <property type="gene ID" value="Ngar_c06560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06560"/>
    <dbReference type="HOGENOM" id="CLU_2340268_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-654-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11315" checksum="BC0FDAC4A3A9CA67" modified="2012-11-28" version="1">MNFKIVVEFDTDNIGTKEKSAYDFYDGIDNYEIVSRIVDEPKAQVGDRIRVGNVYDFQHLPWHKGDMGIMYDIETTEDGLRKLWVGKMGQRQRPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC8</accession>
    <name>K0IMC8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57789">
        <property type="protein sequence ID" value="AFU57789"/>
        <property type="gene ID" value="Ngar_c08470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08470"/>
    <dbReference type="HOGENOM" id="CLU_2857207_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-845-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7504" checksum="85A5AC63BE44B8A7" modified="2012-11-28" version="1">MGIEKKKPLKRDQALHDPTHGQFGEEPRPEPLPDGKVEQDSSNDNIKDRRREARKKSRSVYIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD6</accession>
    <name>K0IMD6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57819">
        <property type="protein sequence ID" value="AFU57819"/>
        <property type="gene ID" value="Ngar_c08770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08770"/>
    <dbReference type="HOGENOM" id="CLU_2366303_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-875-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10615" checksum="C329A7E271AF8CAB" modified="2012-11-28" version="1">MGIEPAIKVKKNSSGKSIGCYLRKVAVLQQLSDFGRWKASVTAMGIGGLQDLCVLCSAMKRMMFGEYVMARNYQNMAKEMFLKASLYNMFVGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH8</accession>
    <name>K0IMH8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hemolysin-type calcium-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60297">
        <property type="protein sequence ID" value="AFU60297"/>
        <property type="gene ID" value="Ngar_c33820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33820"/>
    <dbReference type="HOGENOM" id="CLU_1286377_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3383-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="20438" checksum="54EFC8CF8578D905" modified="2012-11-28" version="1">MVLAATVSGTGRNDTLEGTQEDDTIYGYGGDDEPWGNDGNDILYGNGGNDYINDGTNGNDHLHGHSGNDELLAGFGFDVLYGGSGDDNMHKIFGDSQMYGGTGNDIIMGGRGGVDTISGGNGNDKLYGMLGNDVIGGGYGDNGIDGGDGNDILRGHYDNDILTGGGGADKFYCGSRIDTVTDFNAAEGDTKLGDCENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK0</accession>
    <name>K0IMK0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="3">PNP</shortName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c34420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34420"/>
    <dbReference type="EnsemblBacteria" id="AFU60357">
        <property type="protein sequence ID" value="AFU60357"/>
        <property type="gene ID" value="Ngar_c34420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3440"/>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_2"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3443-MON"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="265" mass="29088" checksum="50BCFFF2F28B2BCE" modified="2012-11-28" version="1">MANSADIGIIGGTGVYDPGLFSSKREIKVHTPYGEPSDLVTIGEYAGVKVAFIPRHGRGHRIPPHSINSRANIWTLKELGVKRIIAPSAVGSLQESYRPGDIAIPDQFIDFTKKRQYTFYDGGQVCHVSVADPFCPELSSIAIDKTKKLKFPMHDRATYVCIEGPRFSTRAESKFFRDVMKADIIGMTLVPEVNLAREAEICYMSIATVTDYDVWADKPVSSAEIIETLAKNVEKTKKLIAELVPAIPAVRKKCACGSALESALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK1</accession>
    <name>K0IMK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis protein cheC, inhibitor of mcp methylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10170"/>
    <dbReference type="EnsemblBacteria" id="AFU57959">
        <property type="protein sequence ID" value="AFU57959"/>
        <property type="gene ID" value="Ngar_c10170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10170"/>
    <dbReference type="HOGENOM" id="CLU_087860_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1015-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="23031" checksum="0E078880B758AA0F" modified="2012-11-28" version="1">MIVKNNHVSISEAEITDLGTTISMLASGTSKSLAMMTGEEYTYSFGRINEVKPQYVDQLVQLFNEELCAVYLRADGDVTVGMMLFLTHEQARQLARRLLGNNDLKELDILGRSSISEVGNILFAGSFLNDMAKYTGFKMKCSVPGFATDTIHGIIEFPISDIAATDNILVIAESELVGKITGTRIKVLIIMGITDARKLAASTGTPKRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP8</accession>
    <name>K0IMP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60467">
        <property type="protein sequence ID" value="AFU60467"/>
        <property type="gene ID" value="Ngar_c35540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35540"/>
    <dbReference type="HOGENOM" id="CLU_2679069_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3555-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8622" checksum="625BE7013082EDAB" modified="2012-11-28" version="1">MLEDFSTFLQFCMKFAIHYMLPLLPLLDIGEHAMTITGHDNFLQRESSQVEKWFARYTKILAVDSLARDIIKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP9</accession>
    <name>K0IMP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60472">
        <property type="protein sequence ID" value="AFU60472"/>
        <property type="gene ID" value="Ngar_c35590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35590"/>
    <dbReference type="HOGENOM" id="CLU_2695901_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3560-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8270" checksum="890396FF6C8AE024" modified="2012-11-28" version="1">MPNLKKEIGVIVNDLGIYHKGLEVAVRRNNIKDEVSYALSAILPLEQKAEETELVKSWAYKKTLQITVQRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU8</accession>
    <name>K0IMU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58249">
        <property type="protein sequence ID" value="AFU58249"/>
        <property type="gene ID" value="Ngar_c13110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13110"/>
    <dbReference type="HOGENOM" id="CLU_2712965_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1309-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="7996" checksum="F6C33322E31F74FD" modified="2012-11-28" version="1">MIPLLNSVDNQAVIQQRVPTGQVFTIATGELLAIMDKIIVGSLAFNMFYGLLVVMLTRSLSEGYLRRNQVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX3</accession>
    <name>K0IMX3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxoguanine DNA glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ogg</name>
        <name evidence="2" type="ordered locus">Ngar_c14380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14380"/>
    <dbReference type="EnsemblBacteria" id="AFU58374">
        <property type="protein sequence ID" value="AFU58374"/>
        <property type="gene ID" value="Ngar_c14380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14380"/>
    <dbReference type="HOGENOM" id="CLU_027543_3_2_2"/>
    <dbReference type="OMA" id="YAQTYVF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="123"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="302" mass="34844" checksum="E0CF46C265901EB3" modified="2012-11-28" version="1">MKKFNKDRRNCLTGLQSLYQSFDPVVSINSGQVFLWEKRGNSWYGVHGDRIVRFAQMIDGHAEFAAFPEDRLCEQKMFRMGDDVRAIFSEISRDPLVRRLVRTYPGLRLMRQEPHQCLFSFVCASNTNIPMIRRMLYTLTRKFGRPVHVDGIEFFTFPSASDINRASIDELRACGLGYRAKAIKAAAGAIATGQLDFDVLKSTGYEEAKKELLQVYGVGNKIADCVLLFSLEKLDAFPIDVWIARALAGHYRWLHKKKFGDKITPHQYEQLSESARDYFGRYAGYAQQYLYYHMRQSAGKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE9</accession>
    <name>K0INE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase, group 2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59254">
        <property type="protein sequence ID" value="AFU59254"/>
        <property type="gene ID" value="Ngar_c23280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23280"/>
    <dbReference type="HOGENOM" id="CLU_598027_0_0_2"/>
    <dbReference type="OMA" id="RIRLRIM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2326-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="PTHR16779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="414" mass="47634" checksum="ADACCA211DB5E009" modified="2012-11-28" version="1">MRRIHNDPAIIFQITTRSATRTPVVRRGILSIRSSAHKVNFYNYQISIVTDDPDDIRTLASERCEVVVVNKDFRTNAIKKGRALQYAVEHRRRAGTNTSKHWIFHMDDESYVTPQTILALLKFIREGKGVASEGPIFYPLKFESANRLTAIAESIRPFACYDCVSQMTHPPPLHMHGSNLLIRSDIEDDIEWNFGPTLAEDQMFGFKVYEKYGHGSMGWHGGILLEQPPLNLKDHFFQRRRWVLGTMQNLQKFPRWHRYKLMFKSITYFLGFASAAASAAFSVNNYLLPMLLSPSYYLNYNIAAWQTKLSTISFDTIAQSIASTSPVELSVAPIMLFTSLVWLASYQTGLFLNLRYSKIGWVKRLLFHMQALLLCPLIGLVETFPAFWATIEYLVKKKRTAEKMPVYDFYVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM9</accession>
    <name>K0INM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59654">
        <property type="protein sequence ID" value="AFU59654"/>
        <property type="gene ID" value="Ngar_c27330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27330"/>
    <dbReference type="HOGENOM" id="CLU_1313166_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2733-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="26469" checksum="01D08DD39D9583B0" modified="2012-11-28" version="1">MKMKNDWQSWSFMNIDLHTGARAFAMASLSWDRIAMSPAFRVEQFEPKIKKASWYLTREGKWWVKYPTEECRAIVETAYDRLPKRDFMFFEDAKSDRANCLRASYFAKRIAIWFRKIFSELDKGTWLNEKTRVYALGDGLYFDGKPLHLFRHTMAQYYLAATNWSLAYVASLGGWENTEILNKCYGGIPEHIRAQISKSVHVRFDTLDLNTLIVATGYSAITPTAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT8</accession>
    <name>K0INT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp20</name>
        <name evidence="4" type="ordered locus">Ngar_c30330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30330"/>
    <dbReference type="EnsemblBacteria" id="AFU59949">
        <property type="protein sequence ID" value="AFU59949"/>
        <property type="gene ID" value="Ngar_c30330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30330"/>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="19105" checksum="EF4DE8CFB5EB35D7" modified="2012-11-28" version="1">MMREMDRMMQEAFKNFEQQVPKNLVKERKLDDGSVVREMGPIVYGYSVKIGPDGKPEVRKFGNIDAFPNLLGGGLSVKEEREPLVDVIRGKDELRVVAEVPGVSKENLRVTADENSVTIESVTGQPRYHKRVELPDMVDPKAAKSTYKNGILEISFRLKGRSGSGVSINIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY6</accession>
    <name>K0INY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32740"/>
    <dbReference type="EnsemblBacteria" id="AFU60189">
        <property type="protein sequence ID" value="AFU60189"/>
        <property type="gene ID" value="Ngar_c32740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32740"/>
    <dbReference type="HOGENOM" id="CLU_614850_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3274-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="445" mass="50171" checksum="460CFD0016A0F21B" modified="2012-11-28" version="1">MFLLVYLIRSFMFIHIANKKAGQLLSIKSRIKHREKFIDQAETPHFNSNLPFVSLLVPTHNESLVIRRLIRSICGLIYPKSRFEVIIIDDSEDDTYDIITDTAAKLPNLKTIRRKNRNGWKGGALNLALDHLDTKSAYVLVIDADNVLAPDTIEQFIIRFSQARQWDDSVIAIQGFPISTSNPIHQEEISNWVARGIDFRLAQRNAIEFLAKNELQLPVQITGSLFMIRTDILKATRFSTDLCEDWELTLDLHCNCKNPQLFPKLRVVFDASLVSYCEATTNFGSYFKQRLRVSEGHTRGFKKKANQVLKSKSLSFTEKFELALTGLQYAKFISILALAMIDAAILSLILADSSTLIVANNQILVISFAIQAGLLVSIVIANFIATRTCAGIRKYGIRDVAGLLALNILTMPAFAIGSFYGFLRKRGIFYRTQRNILDTISDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP46</accession>
    <name>K0IP46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphate ABC transporter, periplasmic phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pstS4</name>
        <name evidence="1" type="ordered locus">Ngar_c35760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35760"/>
    <dbReference type="EnsemblBacteria" id="AFU60489">
        <property type="protein sequence ID" value="AFU60489"/>
        <property type="gene ID" value="Ngar_c35760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35760"/>
    <dbReference type="HOGENOM" id="CLU_2565863_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9289" checksum="FEBE564DF424A6F0" modified="2012-11-28" version="1">MTLLLFTGIIFLSPNGSFAQRQIELNDVGATFPFPLIDTWRVEYQKVRPDVSINYQSIDSGGGVNQFTEKKDWILGHLMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I703</accession>
    <name>K0I703_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c00960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57046">
        <property type="protein sequence ID" value="AFU57046"/>
        <property type="gene ID" value="Ngar_c00960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00960"/>
    <dbReference type="HOGENOM" id="CLU_2534787_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-96-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="8944" checksum="776C8AC8B69567ED" modified="2012-11-28" version="1">MIVLVAGIIVNILVVTGIFMIPCVPATVDMKEEEEKEEEEEGPQPAFGNLTTCNEVRSPGFIILGVADVFAAVLIVSELAKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0I718</accession>
    <name>K0I718_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="7">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asd</name>
        <name evidence="9" type="ordered locus">Ngar_c01110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01110"/>
    <dbReference type="EnsemblBacteria" id="AFU57061">
        <property type="protein sequence ID" value="AFU57061"/>
        <property type="gene ID" value="Ngar_c01110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.114"/>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_2"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="358" mass="39604" checksum="93C62FDAAE4D0801" modified="2012-11-28" version="1">MLKVAVIGATGAVGQEFVIALNRHKWFELTQVAASERSAGKKYIDAIRDPNSGILRWHNREEVPEYVKNMVVSKVDDIKPENFDLIFTALESDDAKIVEPKFAKTTPVISTAAAFRYEQDVPILIPGINDNHAELLNLQRKNRGWKGFVAPLPNCTTTGMAITLKPILDRFGIEKVFMTSMQALSGAGRSPGVIALDIMDNVIPYIPKEEEKVQVETKKILGAMNNGSIAPAPLKVSCTCTRVPVLDGHTESVFVETEQTADAEEVKKEMLKFSKNVSIKDLPTAPKDYIVVHDDPTRPQPRIDRELNDGMTTVVGRLRKDTAFDNGIKYVLLSHNEKMGSAKGAVLLAELLKDRNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7V9</accession>
    <name>K0I7V9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57351">
        <property type="protein sequence ID" value="AFU57351"/>
        <property type="gene ID" value="Ngar_c04040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04040"/>
    <dbReference type="HOGENOM" id="CLU_176747_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-403-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="11963" checksum="004B79C608BB3247" modified="2012-11-28" version="1">MSSSDREKPEQIPSRENIEETKAMVSEQAGVEGERKEVDVRDYPKTAAIGQILKDLDFPADKKRIVEFAEKARPQSEEILSDLKRIEDRQYGSVSDVTKAAGLVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8J1</accession>
    <name>K0I8J1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57596">
        <property type="protein sequence ID" value="AFU57596"/>
        <property type="gene ID" value="Ngar_c06530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06530"/>
    <dbReference type="HOGENOM" id="CLU_2140279_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-651-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12985" checksum="CAD1BD8105889D4A" modified="2012-11-28" version="1">MKRLNRLSFWDRINKLEEDSGYNLLFRDYIAPYREGKDVDVPPKFQKAFNFATKIDDLYWDADYHGLDCAGQSCSCKDTTHKKRTYPKLWKKAGGTGKARRGMENNGGLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I995</accession>
    <name>K0I995_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57906">
        <property type="protein sequence ID" value="AFU57906"/>
        <property type="gene ID" value="Ngar_c09640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09640"/>
    <dbReference type="HOGENOM" id="CLU_2679062_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-962-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8531" checksum="9941CACA622A61B2" modified="2012-11-28" version="1">MRIKKGDSLVMMVKDDKIVLEKSEKIALLLDGEFKDIEAFAEHSLKSVWDNPYDEVWNKDAPVATPRGNKRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9C3</accession>
    <name>K0I9C3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57936">
        <property type="protein sequence ID" value="AFU57936"/>
        <property type="gene ID" value="Ngar_c09940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09940"/>
    <dbReference type="HOGENOM" id="CLU_1178159_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-992-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="26875" checksum="B425087BFEC0A875" modified="2012-11-28" version="1">MKTIFSNVGRMIRGATDENTSRAIDVLSSTPDYYKKIALSDIEIVLKAKSIISEDLDSIAQKINLAFKTSDVKLLNEVMNKHGKTIAIVLALSTARWENQKLLWQHINQNNSEQMPVDILDKEIARIDELAMNLELTLPSLKGNIFQTEKKHKEEDYHYTLRGGYNVPIDKMYNLVVYNIKRTGFLKIVEANEGARVIRFTSDKIEDPRGIIEFTITLVDKIDGGSYFRLHIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9F3</accession>
    <name>K0I9F3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase of the haloacid dehalogenase (HAD)-like hydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10340"/>
    <dbReference type="EnsemblBacteria" id="AFU57976">
        <property type="protein sequence ID" value="AFU57976"/>
        <property type="gene ID" value="Ngar_c10340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10340"/>
    <dbReference type="HOGENOM" id="CLU_045011_8_5_2"/>
    <dbReference type="OMA" id="NCTIELP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1032-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="234" mass="26681" checksum="3187B26E85CC3035" modified="2012-11-28" version="1">MHRPFVFFDLGQTLVDEWDFIAHFDQKFLELLNGFGARIDQRNYRAVRDSIIRDRKIGHGSVRELVIEVCRMLSPQGYDKVIASRLESQIKQGRRDLFRLFDDAEPTLQALSKHCEMGLIANQSEDIQELLEKSGLGRFFKVQTISSIVKLKKPDPRIFELALKQAGRPAHECIMVGDRLDTDICPANTLGMTTIRVTNSLFALQMPAQKCEYATYTVAHLSEIPKIVESIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9U2</accession>
    <name>K0I9U2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="6">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoH</name>
        <name evidence="6" type="ordered locus">Ngar_c11550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11550"/>
    <dbReference type="EnsemblBacteria" id="AFU58096">
        <property type="protein sequence ID" value="AFU58096"/>
        <property type="gene ID" value="Ngar_c11550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1095"/>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_2"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="456" mass="50320" checksum="C6290F3DD877130B" modified="2012-11-28" version="1">MRYRTCWSGKGLQTCLLCIGLSTTGRWRLTGRDMATYPQNFRFGEFVGSLIWLIFWILIIVALVGLPLLFIVLFYVPLPPLGDEVLTPYLFLTMIVDPSRTIPIIEHLMTTDLFRVALFPGFTYAALIAAVTIFVERKFLAKMQLRVGPLYAGKIEGIFQLIADGLKLIAKEIIVPSGADKPMFWIAPIAFVSTAAAVVALIPAAPGYVVADIDVGLLAVFAILGFFPLIALLFSWASNSKYPFIGGLRALHQMIAFEIPFILSALSVVILSGTLNLTGIVESQIQSYWFIFFLPISAFVFYISSLAELERIPFDLPEAESEIVAGWLTETSGMIYGLIQLGSYVKTYALAALFVVLFLGGWAGPMVFPPEVETPIINIAPLYDQQAANATLWFTLKTFGMILLMLLPRGISPRIRIDILLHTGWYKLIVLAFINMFVALALIYGGILGPGGLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAM0</accession>
    <name>K0IAM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58371">
        <property type="protein sequence ID" value="AFU58371"/>
        <property type="gene ID" value="Ngar_c14350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14350"/>
    <dbReference type="HOGENOM" id="CLU_2679064_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1433-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8086" checksum="126E47C2A808C538" modified="2012-11-28" version="1">MAVSGENIYITWQSCLVIDDSAPCAESILFTKSDDNGTTFDKPIILFEGVEAAQARMTIAHDHLSGQDNVAIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBQ8</accession>
    <name>K0IBQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58686">
        <property type="protein sequence ID" value="AFU58686"/>
        <property type="gene ID" value="Ngar_c17530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17530"/>
    <dbReference type="HOGENOM" id="CLU_127468_0_0_2"/>
    <dbReference type="OMA" id="QRHENIW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1751-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="181" mass="20169" checksum="05EE9B2498606C0B" modified="2012-11-28" version="1">MPADVKDLLYSAINEIGKEKIRMDIASNMDVCEKYCVEILGKCQSRLGPETNDETLATLCEALLHFMLTASLLPSERKINVHGVDLDIVIPSTRMLDKSPDKSLVIQVVRGSDPTAKVKQAESVQQRHENIWLISAKQLLHTRYRNYHLGSGGLPYSQIISDISVFLSEKGARGLKLLHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBS2</accession>
    <name>K0IBS2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">serS</name>
        <name evidence="9" type="ordered locus">Ngar_c17780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17780"/>
    <dbReference type="EnsemblBacteria" id="AFU58711">
        <property type="protein sequence ID" value="AFU58711"/>
        <property type="gene ID" value="Ngar_c17780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1754"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_2"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="139"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="6">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="426" mass="48749" checksum="A8033C0B5D704EB5" modified="2012-11-28" version="1">MLDPKLLKENPQAVKDMLNRRNMANFPLDELVTIDRRRRELIVETQELRQKKNVLAEAIARKKKAKQDASSELAQMKEVSSYLGDSEEELVKTEGRFKELMMVVPNMLHESVPTGKDEKDNVVVRQNGSAKKMNFAPKDHVDIAAALDLVDVERAAKVSGARFYYLKNELVKMNQALVNFALDFLSEHSYILVQPPYMIRRESMSGAVILGDFQDVIYKVEGEDLYMIGTSEHAIASMHMDEILDGKKLPIRYAGYSPCFRKEAGAHGKDMKGIFRVHQFEKVEQFVYCRPEDSWKEHERMLALSEEFYNRLGIPNRVMLLCSGDTGKISAKTYDIEAWMAGQNAYREIVSCSNCVDYQARRLGIRFRDRTNEETRLVHTLNSTLVATERTMVAILENYQTSNGTVEVPDALQKYMGGIKEIKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC13</accession>
    <name>K0IC13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Hsp90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58881">
        <property type="protein sequence ID" value="AFU58881"/>
        <property type="gene ID" value="Ngar_c19490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19490"/>
    <dbReference type="HOGENOM" id="CLU_1131644_0_0_2"/>
    <dbReference type="OMA" id="GRRIQIA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1947-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="245" mass="28627" checksum="69E769242EA5A41E" modified="2012-11-28" version="1">MTADTVCVILEERKDMFVLILQGKVQTVPLTPYTEVKYRHFNGNRIAYRFSEEMQVQETYDDGIFNCSYKTAQMQIRKRDAVAEAILQHYGCGSTSAYERLFLQEYADRNCIDLLKFMLAGYRQRLRFEEKSTDDEAIYIEDNFKVDRHGNAYVKDEHGYRRICIVVKGSLSETCVETPIGRVSLDETALTILAKTMFLLNPNLEDEVFRRQMPSRMLAALEEQSQEGMPFWPRLNFFPDKTMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICA8</accession>
    <name>K0ICA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59011">
        <property type="protein sequence ID" value="AFU59011"/>
        <property type="gene ID" value="Ngar_c20800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20800"/>
    <dbReference type="HOGENOM" id="CLU_2257456_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2078-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11895" checksum="C32E6317BD217BD7" modified="2012-11-28" version="1">MQALALVCHEIVSTILISTKRRFVRSLSHDEDSDDDEMELKRLLGVVSDKGLKTLDVVELERLRVLLQAKDYGDNKKANKSKAKLLKQINSAFYDLHRPRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICE1</accession>
    <name>K0ICE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytosine/adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c02770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57225">
        <property type="protein sequence ID" value="AFU57225"/>
        <property type="gene ID" value="Ngar_c02770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02770"/>
    <dbReference type="HOGENOM" id="CLU_681275_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-277-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="423" mass="46486" checksum="C6E3F6D208482C11" modified="2012-11-28" version="1">MFDLATVYVMLRDSRKLAAACKYAEIAVREAENAKSAGTFGVGGLLIGNDGKIYKIIRNTVIQGNSVHDPTAHVERQLVDWYFSKKREKKTKNLLLPPANKTTIITSLDPCMMCSGAILAGGFNVIHISQDSQTGTSCRGVGDFSTLPDGLEQRARETFSAFGVVGNRLFNGPPDSIFSGDEIDSKLDRRSVRAFSSSLKKIKGIINNHHGQSPDKLTDPKTLARSSRIFRLLKKYNSKVFSDGYLVDFDKPGINLGQILVEKAKESHEKSGVFNSACLIDPFGNVLLSEAGAEDASPIRAPFLELVRKYHRLLLEAGAEGSKHLAHLKYCKTVTMLGPGRDPKSLMEVGCFGSCIEGKLPKGEQMQYVIPQQGQDDLQNMLNNLPPLYSDVMRLKDAIHQVKDVQLQQFCTSKATLFASGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICY9</accession>
    <name>K0ICY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57530">
        <property type="protein sequence ID" value="AFU57530"/>
        <property type="gene ID" value="Ngar_c05870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05870"/>
    <dbReference type="HOGENOM" id="CLU_1674041_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-585-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="19832" checksum="4C4AAD4882356F93" modified="2012-11-28" version="1">MYIQKCKAGCQGEGLLHALMPLFGAIRLDGRHNNYSGSIYDWFDEEDTFLDYLSSRYTQDVSKVLPLSGQGTTASQIRGSKRDISMITKTSRYRTTSLDANSVARVQVLETYAGRSCQRTSLLVMTTCVYYYPSFGDLKKKRSRRILRHCFRTRRFYLDMRKYLTEGVSPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDA4</accession>
    <name>K0IDA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59376">
        <property type="protein sequence ID" value="AFU59376"/>
        <property type="gene ID" value="Ngar_c24520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24520"/>
    <dbReference type="HOGENOM" id="CLU_2712971_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2450-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8335" checksum="B66A8B4CC3734F8B" modified="2012-11-28" version="1">MARKGRLEEIFSKALYADDAALYSVSYRDFENIVEVSLPEFVSLSENLQVIPQNRIVLVKKGNQILYRKHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDL3</accession>
    <name>K0IDL3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57770">
        <property type="protein sequence ID" value="AFU57770"/>
        <property type="gene ID" value="Ngar_c08280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08280"/>
    <dbReference type="HOGENOM" id="CLU_2695891_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-826-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8292" checksum="C0126B9D5B045497" modified="2012-11-28" version="1">MGKTLEPKLGKTICIFTEYQNVKTATFALYNQQTLEQEAIVLASFDKSADAYLIIEEKIKPLVRQIRKSIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDN4</accession>
    <name>K0IDN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c08680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08680"/>
    <dbReference type="EnsemblBacteria" id="AFU57810">
        <property type="protein sequence ID" value="AFU57810"/>
        <property type="gene ID" value="Ngar_c08680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08680"/>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-866-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="383"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="619" mass="69203" checksum="5060081744653793" modified="2012-11-28" version="1">MKNITKLILSRSNIILLVIIGAVAISLSALSYQYSTYNARQIAANADEDVRKDTERQATDIRGILENKINTVVSNLHIIANTPSVERGEELESRVLFDTAENTIGAPLDFVAWLNSDGRLVWSSNVNASTWAQYGGVDLSMRPYFIEARDTREPYFSSIIESVDDIPRVFMSVPVIDNEQNFRGIVYAGYRLDTAAQLVRDEVIEEDSESRILLMSKDGVLLYSRSPEFVGRNLLDEAVLAEIIPSRIPGEEREKVNVVLRDALAGKSGSIDITINDVRNTVAFEPVILNGKHFLTLFILTPHIFAKGTAFLIEQQNNVNTIIIAAIGAMAFAMSFLVLGWNKRLQAAVDARTEELQEANKRLIEANEQLKVASKMQKEFINIAAHELRTPTQAILGYIELLELQKEETEDGKKMMTTTDLRGISRNAKRLQRLTEDILDVTRIESNSLHLNLEKFDLSEVIQTAIYDAQSRLANGKIKFIYNNEPKEKRVVITVNADKERIMQVLSNLLDNSIKFTKEGTISISAQRAGDRQVAMVSIKDTGTGIHPDIMPKLFTKFTTKSEKGTGLGLFLTKSIVEAHGGEIWAENNSDVKGATFTFTIPLEQQKTKDDDNNSDNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV9</accession>
    <name>K0IDV9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57930">
        <property type="protein sequence ID" value="AFU57930"/>
        <property type="gene ID" value="Ngar_c09880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09880"/>
    <dbReference type="HOGENOM" id="CLU_2766232_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-986-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="8096" checksum="3600D4F705E0F5F8" modified="2012-11-28" version="1">MENKLGMTIFSIAEYEQVFRTTIMIDENKSKGIEEGSVLIVSIYKDCPDPWSRITKKILPLTRQYQNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDY9</accession>
    <name>K0IDY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57038">
        <property type="protein sequence ID" value="AFU57038"/>
        <property type="gene ID" value="Ngar_c00880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00880"/>
    <dbReference type="HOGENOM" id="CLU_982173_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-88-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="283" mass="31626" checksum="39418E2BF1FE2F51" modified="2012-11-28" version="1">MTDERVLGNAVNVLLPLFRPAGFKRRRYSVVDIANSVVYACTGGTSITQTTCCSILVSTPSRRDVQYHISKIDISWIQSAVNNRVVLQARAKDVLQQCAVNIAIDMTDTPPPTTGSRRTKAMSGADQPKAVYTTHFFFTHASAYVRLHGRRFTLAMKYVRADESLVDVVRYLLAEVQKTGIRIKCLFLDKGFFTAAAVMSYLNSVRIPYIIAAFPRGRKTGGRLSKLTRKRRDSFVVPDYEIIDSNTGEKCTFRLYAWQSTVRSGTGRRRITASSTCSMPQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDZ6</accession>
    <name>K0IDZ6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c10380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10380"/>
    <dbReference type="EnsemblBacteria" id="AFU57980">
        <property type="protein sequence ID" value="AFU57980"/>
        <property type="gene ID" value="Ngar_c10380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.988"/>
    <dbReference type="HOGENOM" id="CLU_031618_1_3_2"/>
    <dbReference type="OMA" id="GYPRVKG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1036-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="152"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="31685" checksum="20FEDC01BB74D97E" modified="2012-11-28" version="1">MADTGWLADNLNNPNIRILEVDYDPENAYRQGHIPGAYLVWWKRDINDAVRRDIISKQQFESLMSRIGATRDTELILYGDFNGWFAAFAFWVFQYYGHKKVRILDGGRIKWEKEKKRYTKDVPPIQNSRYIAAPADEGIRAYVPDVRRAIERDGETVLVDVRSPKEFSGEITAPPEYPTEHAQRGGHIPTAVNIPWAQAIKEDGTFKDPNDLRALYEAKGVTPDKHVISYCRIGERSSHTWFVLKYLLGYPSVSNYDGSWTEWGNMIGNPIEKGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEI3</accession>
    <name>K0IEI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="5">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cdc48</name>
        <name evidence="5" type="ordered locus">Ngar_c02250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02250"/>
    <dbReference type="EnsemblBacteria" id="AFU57173">
        <property type="protein sequence ID" value="AFU57173"/>
        <property type="gene ID" value="Ngar_c02250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.224"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="IEPAGEY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="200"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="473"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="717" mass="78505" checksum="EE703BEC6C457916" modified="2012-11-28" version="1">MEAYARDVGKGIARIDYDTMASLGVAAGDVLEIKGSRRTVAKCLPLYPSDEGKNSIRIDGLMRNNAGVGIGDMANAKKVKAVPAEKILVSPLEAMPPIDERYISDSLENTPLVKGDNIMLPYFGGRLTFQVVGVTPPADAVLVTSKTLFTITEKDADLRGMPHVSYEDIGGLKDELQKVREMIELPLRHPEIFEKLGIEAPKGVLLFGPPGTGKTLLAKAVASESNAHFITISGPEIMSKFYGESEARLREIFKEAKDKAPSIIFIDEIDSIAPKREEVTGEVERRVVSQMLSLMDGLEGRGKVIVIAATNRQNALDPALRRPGRFDREIEIKVPDKHGRLEILQIHSRNMPLDTDVDQPRIAAVSHGFVGADLEYLCKEAAMKCLRRLLPELNMEEDKLPPATLDKLIITQNDFDQAIRDVTPSAMREVFLESPDVKWQDIGGLDGVKRELQEAVEWPLRYPDLYAKLGHKVPKGILLHGPSGTGKTLLAKAVATESEANFISVKGPELVSKWIGESERGIREVFRRARQAAPCVIFLDEIDSIAPTRGGGMEGGGGGSGTERIVSQILTEIDGISELHGVVVLGATNRPDMVDPALLRPGRFDRIILVPNPDSKTRAKILEIHANGKPIGQDVNIQKIAEAMTEGFSGADTAAVVNTAISLVLHEYLAKYPTPEEAAKHATEAHIMLRHFEQAVKKIKTQRDTKPREAMALSLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEN9</accession>
    <name>K0IEN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58220">
        <property type="protein sequence ID" value="AFU58220"/>
        <property type="gene ID" value="Ngar_c12800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12800"/>
    <dbReference type="HOGENOM" id="CLU_2447763_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1278-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9820" checksum="AB0BC9A2FF909B1A" modified="2012-11-28" version="1">MTTKKAYDEDRIISGTELAKCFDNLKEHLGGAMTETIAYELEVMFGIVAVGRLSYKLSQIDDALTKLLGGSASEIMMESIAKHFGMQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEU1</accession>
    <name>K0IEU1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MIase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58280">
        <property type="protein sequence ID" value="AFU58280"/>
        <property type="gene ID" value="Ngar_c13420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13420"/>
    <dbReference type="HOGENOM" id="CLU_1987691_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1340-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="13930" checksum="2A2DDB0EE585AE57" modified="2012-11-28" version="1">MGAHLSCMLYLVIDAVKLEFVSPDLAVAQMKMLQQTFSIYRELKEQGKLKFAYAFADSPGGIMVLDVASNEELQQTLFLLPSMPLVNRTVRPLTEIKQVEDLITELESIVSSMPRTPGEKKPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEW4</accession>
    <name>K0IEW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Large-conductance mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="10" type="ordered locus">Ngar_c13730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13730"/>
    <dbReference type="EnsemblBacteria" id="AFU58310">
        <property type="protein sequence ID" value="AFU58310"/>
        <property type="gene ID" value="Ngar_c13730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13730"/>
    <dbReference type="HOGENOM" id="CLU_095787_4_0_2"/>
    <dbReference type="OMA" id="CSSWQDG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13412" checksum="D4AD654FEAA5AB61" modified="2012-11-28" version="1">MAVTESAPTNKKTLIQEFVDFLKTFGVIGLAIAFIIGAASSSLVTSLVQDIINPLVGLFLPSGDLEQLYVNATGVSGTPSQFRYGHLISEIIDFLIIAFIVFLTYKWLSKYRLVEDKTKPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEY6</accession>
    <name>K0IEY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59921">
        <property type="protein sequence ID" value="AFU59921"/>
        <property type="gene ID" value="Ngar_c30030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30030"/>
    <dbReference type="HOGENOM" id="CLU_147147_0_0_2"/>
    <dbReference type="OMA" id="VWLYALR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3003-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="15960" checksum="8A3369FD65C9B2DE" modified="2012-11-28" version="1">MLLGQLLLQTGAEIAIIAAAVIVGLIALWIIVTIPVWIAAKILTLGRAKFTRAMLVTAVGPIVYAIVFFISVAVLTVALGDPTIPAIIAFILAFIAWIGVFKKGFETGWIRALAIAILATIVFAIIGVIITLIMQAIVPGAPPITPIPLQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF26</accession>
    <name>K0IF26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58380">
        <property type="protein sequence ID" value="AFU58380"/>
        <property type="gene ID" value="Ngar_c14440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14440"/>
    <dbReference type="HOGENOM" id="CLU_2911650_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1442-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6659" checksum="DBEF2452729252AE" modified="2012-11-28" version="1">MDQWYAGITTDDGVEKAAVKVDVTKPVGIDVGLLNWLTLSDGKVILNTLDFGARINKIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF44</accession>
    <name>K0IF44_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh2</name>
        <name evidence="4" type="ordered locus">Ngar_c04840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04840"/>
    <dbReference type="EnsemblBacteria" id="AFU57428">
        <property type="protein sequence ID" value="AFU57428"/>
        <property type="gene ID" value="Ngar_c04840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04840"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.462"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_2"/>
    <dbReference type="OMA" id="GIPWLGH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="346" mass="36985" checksum="FD282A5F3C926031" modified="2012-11-28" version="1">MAEKMRAMVLTKLAPIETRPLKLMSIDRPVAKGRNELMIEIEACGVCRSNLHLIEGDWKRFGAPSHLPVVPGHEVVGVVKQVGSGVKKIKVGDRVGIQPLFSSCLQCEYCTTGKENLCESAEITGETVQGGYAEYISALEEFVTPIPDNLDSEHAAPLFCPGITAYKAVKASEPAAGRTVGIFGIGGVGHLAIQIAKMQGARVIAMSRAKKHLDLSKKLGADNVIVYQDSQGQFLKNLKKEEGGLLDSAIVFAPSDKVIDTAIKSVKKGGTIVLGVLGNVSDFPTFEEKIVKGSVIGTMKDMAELVSLASSSGLKVVIETHKLEEANEVLARLKKSQVEARAVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFE0</accession>
    <name>K0IFE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58530">
        <property type="protein sequence ID" value="AFU58530"/>
        <property type="gene ID" value="Ngar_c15970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15970"/>
    <dbReference type="HOGENOM" id="CLU_2629853_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1595-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8889" checksum="20F083239C26CFC7" modified="2012-11-28" version="1">MIIMADLVHQIEGILRKDPSRMYSKEEILNLLAPIKKDEEIERLLAELEVSSSLKESKSDVYATCRGGTVYYKWNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFK5</accession>
    <name>K0IFK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC uptake transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mntC</name>
        <name evidence="7" type="ordered locus">Ngar_c06700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57613">
        <property type="protein sequence ID" value="AFU57613"/>
        <property type="gene ID" value="Ngar_c06700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06700"/>
    <dbReference type="HOGENOM" id="CLU_028808_4_3_2"/>
    <dbReference type="OMA" id="CALLSCW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="296" mass="32021" checksum="307B83BBEED5A2C4" modified="2012-11-28" version="1">MDFLLQPFQYEFFTRGIVVAIMVGGACGLLGVYIVLRGMSYIGHGMSHAVFGGAAVSYIVNINLYIGAALWGFLSAFLINEISRRSKIKADAAIGVVTTAGFAVGVLLISTTRSFTRNFEAILFGNILGITDQDLLMIFVASAITVLFVIFFHKRLLFTLFDKETAKAYGVKTEHVETIFSLVLATVVIASMSAIGVTLLAAAIVAPAISARMLTNNFQKMIIISTVIGAITSFAGMYASFYLDSASGATIVLFSAAAFGISALYAFLRRKYHEHSHAGMVHVHPHSHTAEHRHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFZ1</accession>
    <name>K0IFZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57723">
        <property type="protein sequence ID" value="AFU57723"/>
        <property type="gene ID" value="Ngar_c07810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07810"/>
    <dbReference type="HOGENOM" id="CLU_3039175_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-779-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6658" checksum="6485E9F0934BCEBB" modified="2012-11-28" version="1">MEKHSQIPGDIQRKAFDKFDVFGIVFRDYLIEEIERQGIVFDYKHHYRLQEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG19</accession>
    <name>K0IG19_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57753">
        <property type="protein sequence ID" value="AFU57753"/>
        <property type="gene ID" value="Ngar_c08110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.776"/>
    <dbReference type="HOGENOM" id="CLU_1182846_0_0_2"/>
    <dbReference type="OMA" id="SWILTIQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-809-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="228" mass="24988" checksum="A00D2DC9509F688C" modified="2012-11-28" version="1">MHLLLVLITALILFLPPFAFAQDQDYQVIKSDRSESFVLPYTASNQDKDNPLVYTFDEPKQPSWILTIQNNLSYVPGNDSKTIIKIQEPAPSEKYIEIAMFGGNSTRYWVAVNTPEAGYARIYDQNDGWTADNPVSVTHSENGGLSVTNGRRTVVDSLNLNGFAAGSIAVYGNDDEKVTANAFAGDISFQILFGSFEQSPLYLVPAAVMAGVGGLVIGLLIFKKRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGJ8</accession>
    <name>K0IGJ8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c35980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35980"/>
    <dbReference type="EnsemblBacteria" id="AFU60511">
        <property type="protein sequence ID" value="AFU60511"/>
        <property type="gene ID" value="Ngar_c35980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3606"/>
    <dbReference type="HOGENOM" id="CLU_068610_0_0_2"/>
    <dbReference type="OMA" id="ADAIFFM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3599-MON"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="248" mass="26322" checksum="CCD8B788FEF3685C" modified="2012-11-28" version="1">MTLGKVEQYLRNEIKKHGTICLPLIDSENSTDAAAIARKVEEKGASAILVGGSSAIDQLELAKVVAEIKSKIKIPVILFPGNVTGVSPKADAILFSSLLNSEDPYFITGAQALGAIAVKKYGIEPLPTAYIIVGEGTAAWFVGRARGIPFHKPNLAVMYSLAAQYMGMRFVYLEAGSGASQNVPVEMVAAVRKQYEGTLIVGGGIRSPETAGQIAKAGADIIVIGTMIEKDGDWQEKFSSIVKAIRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGK1</accession>
    <name>K0IGK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like nuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58930">
        <property type="protein sequence ID" value="AFU58930"/>
        <property type="gene ID" value="Ngar_c19980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19980"/>
    <dbReference type="HOGENOM" id="CLU_749285_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1996-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="365" mass="41502" checksum="98973FAEB8F53EB5" modified="2012-11-28" version="1">MKSSATLSKNSIQAISLDHLKKNGWNCNTMTKEEFESLKTSMKIEGQVNPVLVTPRADYFLIIDGEKRFDAAIDLGWKSLQAIVEDSINDDQVKVRCFTSHYNRGFLDPIKTFKLFYGEWMRESSKAYDDGEDEGGSGKEKVTTRQLEQKYGVDQSWISRILTIREIPEPVRNYISSLMRDASKRFSITHAIVLAEKAQAIPEVELKKVVDYFFSPQNKKVESYTDLRFLLETVVQELHSKTPNDDDDDVADGSNRQDSDDDDDNEHNEAPSKTGKGFACSRNGGSFPTSRSKSRHVVEGNFDCEGCDSHYMIDWNNKRVLKLTPEDTFVRASEVQALPTKVTDGCPRCGNQISIDFEGRTFRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGL4</accession>
    <name>K0IGL4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58950">
        <property type="protein sequence ID" value="AFU58950"/>
        <property type="gene ID" value="Ngar_c20180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20180"/>
    <dbReference type="HOGENOM" id="CLU_2044488_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2016-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="12487" checksum="CA824EA1530F4285" modified="2012-11-28" version="1">MKETVTDPSGETVSNGEFDESFFTTIKPEGTGTYTVIVTNIGTQTAMVSGSFGYMPFASADGQPNFDDMMSGGLDMLILGGSLAAAGVVTLIVGGVITIADGRRHETTTTSESGVTYRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGV0</accession>
    <name>K0IGV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59075">
        <property type="protein sequence ID" value="AFU59075"/>
        <property type="gene ID" value="Ngar_c21450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21450"/>
    <dbReference type="HOGENOM" id="CLU_2857212_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2143-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="6916" checksum="7D425D3C1D750971" modified="2012-11-28" version="1">MALETDTLGHDYNSGAGAILSNSFSLIYWTTYLANVKRVCKVTRHFESSNKIAAGTPAFDCSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGV8</accession>
    <name>K0IGV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59085">
        <property type="protein sequence ID" value="AFU59085"/>
        <property type="gene ID" value="Ngar_c21550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21550"/>
    <dbReference type="HOGENOM" id="CLU_2433973_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2153-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10825" checksum="F0038CECBDE3E64F" modified="2012-11-28" version="1">MADWFKNRGFGSSGDEIDQLTKTINEHSDEQRKIMAQFNKAMNNFATERSLETCLDALNLSMQLANVRGKLAESYEYYARMLEREITRLSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW0</accession>
    <name>K0IGW0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="7">IPP isomerase</shortName>
            <ecNumber evidence="7">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="7">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">fni</name>
        <name evidence="9" type="ordered locus">Ngar_c21600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21600"/>
    <dbReference type="EnsemblBacteria" id="AFU59090">
        <property type="protein sequence ID" value="AFU59090"/>
        <property type="gene ID" value="Ngar_c21600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2139"/>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_2"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="299"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="358" mass="38332" checksum="883ABE97713C8030" modified="2012-11-28" version="1">MPSDIEIIKQRKKDGIDIPLQKDVQAKTTSTYLEYVRLVHNALPELDYDDIDTSTTFLGKKFSAPIIIDSMTGGTDEATVINGRLGELAEKYGFGMGLGSQRAGLKSEELAATYSIARKNAPNAFLIANIGGAQLAKGLTIDEARKIVKMIKANALVVHLNPLQELVQPEGEPRYKGVLGKISDLAKTIDVPVIVKEVGAGISREVAIKLEMAGVAAINVAGAGGTSWAGIEKMRAEAMKDDLKRHLGEMFWDWGIPTAASLIETRRAVKLPLIASGGLRNGLEVAKCVALGASMAAMAYPFLRAASQSRESLFAFADTILAELRSTMFLVGARNINALASSRYILTGALAQEVSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGZ3</accession>
    <name>K0IGZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58113">
        <property type="protein sequence ID" value="AFU58113"/>
        <property type="gene ID" value="Ngar_c11730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11730"/>
    <dbReference type="HOGENOM" id="CLU_2911647_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1171-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6779" checksum="3245B6873A288AF8" modified="2012-11-28" version="1">MSTLTSKRTLLVDDEQDVLTVFKKALGSKGYEVDAFNDPTKALIDFAPGRYDIVITDVKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH72</accession>
    <name>K0IH72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12530"/>
    <dbReference type="EnsemblBacteria" id="AFU58193">
        <property type="protein sequence ID" value="AFU58193"/>
        <property type="gene ID" value="Ngar_c12530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12530"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_2"/>
    <dbReference type="OMA" id="SPQDSCV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1251-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="218" mass="23486" checksum="DB2B8966125142C2" modified="2012-11-28" version="1">MGFADLALKGQVPADEALKVIVKEARRLQRLTNDILDVSRIDGGRISYMMEEIKLNDLVLNVINSARVNVGDRVSLKTAINTEKDLVIRGDRERLMQMLTNILGNAAKFTKEGAITVETGYSDRGKGDVVIKVSDTGGGIPGEVLPNLFGKFVTKNVGNENKQGTGLGLFISKAIVAAHKGSISAHNKDGASSQYRCLSMQASEHTSISLQNPLSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHD7</accession>
    <name>K0IHD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57177">
        <property type="protein sequence ID" value="AFU57177"/>
        <property type="gene ID" value="Ngar_c02290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02290"/>
    <dbReference type="HOGENOM" id="CLU_2911644_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-229-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="7002" checksum="82416CC6A17F25D6" modified="2012-11-28" version="1">MPEVHRRVINVKIIDDIQNAGMQVQLANMYIAAAHIIRRGIEKLYIMTMVGLCDILRLPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHH8</accession>
    <name>K0IHH8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24610"/>
    <dbReference type="EnsemblBacteria" id="AFU59385">
        <property type="protein sequence ID" value="AFU59385"/>
        <property type="gene ID" value="Ngar_c24610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24610"/>
    <dbReference type="HOGENOM" id="CLU_481133_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2459-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="594" mass="64075" checksum="E3C798ADB49491C6" modified="2012-11-28" version="1">MTKINCKGCRGLSTVIGAVFMILITLGALNVVLWTMQQQDRVTQSIIEKSSSELNRLNEEIDITDVRVTSNKKLNMTVANTGGAAATIKSIYIVNETSKEQFRYDLNKVVDGRKSVNIGNELPLSIKNNTKYSIRVVTESGNTATTNLTPISSVALPMALYVIPPTFTPGENVTVLYTVTNNLTDSQLTGPVKLNLTYTVDCSPLGSASCNVIKHVQPPSNITTIAKGSTALFKWIFEVQIPDEKYINFNASLANAKQGNWVRERAYSKLIEESQISASTTQVIYTSLVQKPEIFLILPSPFGENTEKGLWGVVVSNPTKVPMTVSRIVINAYTSKPAQGGVNSFIIKSGNNCETAIYPGTGDSPQWTCPHENMIQWKNTASPEIVDPLSSKSFLARVQSDDPTEEPAFMVSVTVFTNMGQFTKTGYSSGAAASTNAIANVFMSKTGSASNAYQDGNILTHINGIASGSTIRVNMTVVDFDKAGDKYIKSGTKLIINVPTDFTDVVVITPLSGFSSAIVTPYDDGSTQIVAELSEHVGNDNNAVEAKVLSFTAKVPIVTSKKVYIMYALLDGQSNPNDFSVGALAEMPLQVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ6</accession>
    <name>K0IHJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59415">
        <property type="protein sequence ID" value="AFU59415"/>
        <property type="gene ID" value="Ngar_c24930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24930"/>
    <dbReference type="HOGENOM" id="CLU_148456_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2491-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="15129" checksum="A0CEECE8999741A7" modified="2012-11-28" version="1">MSEQPSILASQVRRHGITGIAIHLAGFAIGFVSTGLVLQGVIGIEAGTTVLTPFADLLYGLGLVIVVAVAARAGVPMKYLAIAGAVIGVGLFYRGQPHEIHIASGIGFGITHPAHIGLGHLLMTVSAAALAALAFVLNRFRREDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ8</accession>
    <name>K0IHJ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding domain of putative signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c24970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24970"/>
    <dbReference type="EnsemblBacteria" id="AFU59420">
        <property type="protein sequence ID" value="AFU59420"/>
        <property type="gene ID" value="Ngar_c24970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24970"/>
    <dbReference type="HOGENOM" id="CLU_2152689_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2496-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12114" checksum="C7CAC405D3F4525A" modified="2012-11-28" version="1">MKKRGQLQSGWKKNDTGYAHVGIKDTGTGIAPDMMPRLFTKFSTKSEQGTSLRLFISKSIGEAQDGEIWAKNNPDGEDATFSFTLPVAESQEQTPTRGQGSSNFISKVNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHL0</accession>
    <name>K0IHL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-aminoadipate carrier protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lysW</name>
        <name evidence="1" type="ordered locus">Ngar_c14570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14570"/>
    <dbReference type="EnsemblBacteria" id="AFU58393">
        <property type="protein sequence ID" value="AFU58393"/>
        <property type="gene ID" value="Ngar_c14570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14570"/>
    <dbReference type="HOGENOM" id="CLU_195720_1_0_2"/>
    <dbReference type="OMA" id="PEVQEDW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13946">
        <property type="entry name" value="LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="5988" checksum="C40E711C6519DCB4" modified="2012-11-28" version="1">MVVKCPECDAEIKIPSDSIEGEIVTCPDCGASYELVKSGEGFEIKPAQVVGEDWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP5</accession>
    <name>K0IHP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57337">
        <property type="protein sequence ID" value="AFU57337"/>
        <property type="gene ID" value="Ngar_c03890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03890"/>
    <dbReference type="HOGENOM" id="CLU_2597855_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-389-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9615" checksum="7AD54FECE0CD98D3" modified="2012-11-28" version="1">MVEKIIEKREQFVKEQPEFFRTMISTIQAEIDKTVDEKLKAKFRRQLLAFQKLQARFERNRPKLMADTELMKRELNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ1</accession>
    <name>K0IHQ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57352">
        <property type="protein sequence ID" value="AFU57352"/>
        <property type="gene ID" value="Ngar_c04050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04050"/>
    <dbReference type="HOGENOM" id="CLU_2505058_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-404-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9772" checksum="B7A65E0E285DC556" modified="2012-11-28" version="1">MYIFALILHESHNILQHTYLQKEIMTVVTIVWWKGLLLANSVPKNSLCLMLQGGMLSESIREMRKLLRGISLASAEKSSVYCKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0II03</accession>
    <name>K0II03_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06390"/>
    <dbReference type="EnsemblBacteria" id="AFU57582">
        <property type="protein sequence ID" value="AFU57582"/>
        <property type="gene ID" value="Ngar_c06390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06390"/>
    <dbReference type="HOGENOM" id="CLU_095575_0_0_2"/>
    <dbReference type="OMA" id="KNFTSAM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-637-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="30811" checksum="972DB648629CDA34" modified="2012-11-28" version="1">MQASSKFIAEAAEKSRELQRRLSARLSRQSVSFSDELDIRSPELMPLICYPRFSESEYNDRIAEMESLGVTSISPGGRTTINGFRVAGKGHVGLVLRAKIGGKACALKIRRVDADRKSMDGEVRLHTMANDAGVGPRLEGHSKNLIAMEFVDGYSIIDWVKGATKDRLRKMARLVLEQCYSLDRAGLDHGELSRLNRHVIIVSDRPYIIDFESASTARKTSNVTAAAQSIFLHGAIAEIMVKRTLQTDREKALTALKTYKRDQTRTNFDAVLDSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II38</accession>
    <name>K0II38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59595">
        <property type="protein sequence ID" value="AFU59595"/>
        <property type="gene ID" value="Ngar_c26740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26740"/>
    <dbReference type="HOGENOM" id="CLU_3075481_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2674-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5924" checksum="24D06F0A839705F2" modified="2012-11-28" version="1">MFMNEVQEQQVTWEYTELEVIATMPLEAGTKTIEIVSTVPIEETLSSEQFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0II89</accession>
    <name>K0II89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59660">
        <property type="protein sequence ID" value="AFU59660"/>
        <property type="gene ID" value="Ngar_c27390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27390"/>
    <dbReference type="HOGENOM" id="CLU_2490572_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2739-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9124" checksum="FEE4E6379EACDA51" modified="2012-11-28" version="1">MFMFCCAGLFGGFVLGAATGIPWMPLVAAGIGAGGGILTDITILRALDERKEKNAKSQPINRAIACCNSLIRKKKQKSEDLELPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF2</accession>
    <name>K0IIF2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57827">
        <property type="protein sequence ID" value="AFU57827"/>
        <property type="gene ID" value="Ngar_c08850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08850"/>
    <dbReference type="HOGENOM" id="CLU_1801755_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-883-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="16335" checksum="AB45715BE42DB368" modified="2012-11-28" version="1">MYPTLQKKICLCPVIRDIYIHNKDNKVIIRDSGKDSSKMPEKRNNDVDNNNNIISNTDRVLIPSTVIKQVIETSLNMLMPTFKDQVLLDMRNAGLRLDDEIASYSLSQVRDYFHLAFGADAADLLLDVVRNTLEKTGQFKKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF4</accession>
    <name>K0IIF4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58788">
        <property type="protein sequence ID" value="AFU58788"/>
        <property type="gene ID" value="Ngar_c18560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18560"/>
    <dbReference type="HOGENOM" id="CLU_2490570_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1854-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9954" checksum="2DC80B8B2BA98C52" modified="2012-11-28" version="1">MSVKKVISKDRVKEYMIVTLVSHIVGQLVFLPWNLYVMNFTPEQFLRGAIASIPIAFIWNYAGIKVNLYCSYKVKSFVENVATRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR3</accession>
    <name>K0IIR3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58963">
        <property type="protein sequence ID" value="AFU58963"/>
        <property type="gene ID" value="Ngar_c20310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20310"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OMA" id="DRRHEQD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2029-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="89"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="159" mass="17679" checksum="BFA0778414322A17" modified="2012-11-28" version="1">MSFDVKHNDEMSQKNSGATVADYMTTKMITMGWKDSVFDAAKRMMERNISSIAITDDKDRIIGILTERDVVKIVANSVPPSGITAGSLMSYQVVSIEKGSSVEDAARVMGQKKLRHLLVEDANNQDIMGIITVTDLARYLKRNLADEDLAASEVWELFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR8</accession>
    <name>K0IIR8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58002">
        <property type="protein sequence ID" value="AFU58002"/>
        <property type="gene ID" value="Ngar_c10600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10600"/>
    <dbReference type="HOGENOM" id="CLU_1375562_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1058-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="21969" checksum="E4678202CB173659" modified="2012-11-28" version="1">MVYNYSNMIIDLTSWIDIPPEKFSLSTLPNPVVLRQGEQKNIGVQLESASGFIPKVVDYLPINNYPNIEIHYDEDSSNNSSRINGPAPFKIKVSENAQIGQYVVPVITNISTGSIFPSKFLELANFNFSIPAEGNIVQEVNLTISVVEPLTFQEQIKEFWSAYGAIISLVGAGFGGALATYVLDYFKNRKLSKKRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX6</accession>
    <name>K0IIX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59935">
        <property type="protein sequence ID" value="AFU59935"/>
        <property type="gene ID" value="Ngar_c30190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2990"/>
    <dbReference type="HOGENOM" id="CLU_158652_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3019-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="14500" checksum="D45A4B7E33CB3277" modified="2012-11-28" version="1">MSTSLHRMLGAHLIDKDRQLLYRLAKSGSVWERRIAIISTFYFIRNGEFNDTLKIAEMLLHDDYDLIHKAASWMLREVGKRDAAAEEVFLNRHYMTMPWTMLRYAIERFPERKKRRYMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ44</accession>
    <name>K0IJ44_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58177">
        <property type="protein sequence ID" value="AFU58177"/>
        <property type="gene ID" value="Ngar_c12370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12370"/>
    <dbReference type="HOGENOM" id="CLU_1202653_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1235-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="230" mass="25112" checksum="F4B91A03EAEB6D23" modified="2012-11-28" version="1">MTGETQLRARRTRIKILRAIADRNGVAGFSDIKVSTGLSTGSIYYHLERMGNYVTKDSKHYMITEEGLQFLREADPKYSGLAPPKKEEQVQQPEDSSRSEEMVRQTRHGMRQYYVVAGIIMASIFAFAAAAGVLGGWQVLAVFAGVNTGVAASVIIAVALLVSFVMLGRRAYPIIGYRGTVVSALALGIVFASVLAMFSSPQFTGAAPAQSFDNSMDALRSSYSMHWQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ46</accession>
    <name>K0IJ46_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12470"/>
    <dbReference type="EnsemblBacteria" id="AFU58187">
        <property type="protein sequence ID" value="AFU58187"/>
        <property type="gene ID" value="Ngar_c12470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12470"/>
    <dbReference type="HOGENOM" id="CLU_1346449_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1245-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="203" mass="22753" checksum="6C8844E19EC80129" modified="2012-11-28" version="1">MSDTENPVAIFISYNSADKQIASNIAIFLAAENIPTWFDEWKVSAGDSIVGEVQEGLKGCTHFLILWSKNSNKSNWVRKELESTIARAIQTKVPRIIPIRLDDTPLPALLADIKYLRYRGGTERDRYDLVESISGKKPSADFIRAIVKKYKEVVRDPDAEGPFEYKVCPECGSDNLEGSSFVSSDEEFYVLGCKECGWSTVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ67</accession>
    <name>K0IJ67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58257">
        <property type="protein sequence ID" value="AFU58257"/>
        <property type="gene ID" value="Ngar_c13190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13190"/>
    <dbReference type="HOGENOM" id="CLU_2802395_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1317-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7470" checksum="E0582F77D50BB912" modified="2012-11-28" version="1">MIIEKPSSVTTTMQLLRQNKIAYSSFFLRQLMASAVWSMFPIFLGSGDIGIGAIYATNAITQFVFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA4</accession>
    <name>K0IJA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60100">
        <property type="protein sequence ID" value="AFU60100"/>
        <property type="gene ID" value="Ngar_c31840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31840"/>
    <dbReference type="HOGENOM" id="CLU_2581542_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3184-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8805" checksum="8D57ABD6DFE2189E" modified="2012-11-28" version="1">MDDDMEYATIIEVKYSNGITEMLGWQTGQIASNGSVVGIGISWTPLKADTYQLRAYVLSGLDNPLIYSTVVMSEVTIVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB6</accession>
    <name>K0IJB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-6 DNA methylase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22680"/>
    <dbReference type="REBASE" id="55354">
        <property type="entry name" value="Nga92ORF22680P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59198">
        <property type="protein sequence ID" value="AFU59198"/>
        <property type="gene ID" value="Ngar_c22680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2246"/>
    <dbReference type="HOGENOM" id="CLU_306222_0_0_2"/>
    <dbReference type="OMA" id="ENCLANV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2266-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="302"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="453"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="976" mass="110394" checksum="49FC7A6BFC75817B" modified="2012-11-28" version="1">MALTGRMGENTCNAILTEQLNKKGLRASFERHFTTLEGIKKPDIFIESDGYYFIEGKQSPQAQLIHAVSKAHIYKETIKSNIRAKGVFAVVYPQKCEGPCEAAILLDRPPYYIEYRAESLENLSDWIKAFVERPEAPREINTADAIRLLNQAVDSMVYSFTKLEISEINDIFGGKTFFESVLGYEQEKDVPKQHLRTAAAYLLVNQIMFYQVLARETNDYDVLDSEKITKPAELKNTYFAKVLLKDYKPIFDFDIASKLKDEESLEAIKTTINVVNALSPEKHGHDILGKIFHNLIPLDIRKVVAAYFTKSEAGDLLANLSIDSANSTVIDPACGSGTLLVSSYRRKKDLILADGEQFTAKVHRAFAEQQITGVDIMPFAAHLAAVHIALQSPLYYTDNLRIAIHDSTGLTPGETIDAAQQTLKEYFKTGKITDYIGENIDTSSRKIVKGVVKMAETPTKPMEIEKVDVVIMNPPFTSQTRIPSDYKRSLDRKFVDYQKYSHGQLGLHGYFIFLGDKLLDKNGKLAMVLPATILRLQSTEGVRKLLFNNYHVSHIITTMQKAAFSENASFREILLIATKGKHFKQDENVTRLKNKICAVVSLREIPRSSDDAVKVARAIRARTAKMKAGDLVTTDLFTIKTIDQEELQGLTKNAFVLMAFSDWKVSDIWLQIVKVGKPKMDNLENCLANVKGGIVRGIEIESKDEVSVLSTFISRTEERALKSGDVWVLKKEKLNSVLAENKVTHVQVEIPKKVLKFGIRRLTGISTIDITDKLDFVVIDKFEDIDSFFGHQFKSFAKLDKWRRYVESRVANLTVNRRFNISAPGTNLLSFFTSEDATPAKIMWCIQNIRINDAKILCLWFNSTINIIQVLAQRSETEGAFLELSEYMLAEFSVLDPSKLREAEREELIKVFDEIKKSELPSILEQLKNEHPARQKIDRTILKVLGFNGRQIDEILAYLYPALTKEITRLKSLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC9</accession>
    <name>K0IJC9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c22960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22960"/>
    <dbReference type="EnsemblBacteria" id="AFU59223">
        <property type="protein sequence ID" value="AFU59223"/>
        <property type="gene ID" value="Ngar_c22960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2272"/>
    <dbReference type="HOGENOM" id="CLU_1324058_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2294-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="21921" checksum="3BF04FF6740F0DB8" modified="2012-11-28" version="1">MTATVTEYVCEDCGTLLRHSNPNTLESMRDVHNQLCIVKRQKTMAAQAAVPKPAAAPAAPAAVSPTAAAPPPAIPAAPSAPAAGGPTTISLSGTGTNYGKVEGPIDPKFKEKRQQVGTYQGIKVWGPYDAPGQLGIWGDYVCIDFDICVADGACIEACPVNVYEWLQTPGHPASDKKAFMIREKDCIFCMACENVCPPQAVKIFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH9</accession>
    <name>K0IJH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA synthase</fullName>
            <ecNumber evidence="4">2.3.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hcs</name>
        <name evidence="4" type="ordered locus">Ngar_c24080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24080"/>
    <dbReference type="EnsemblBacteria" id="AFU59333">
        <property type="protein sequence ID" value="AFU59333"/>
        <property type="gene ID" value="Ngar_c24080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24080"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2380"/>
    <dbReference type="HOGENOM" id="CLU_008065_3_2_2"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="184"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="469" mass="53027" checksum="0AD2BA1C53389B85" modified="2012-11-28" version="1">MSVMPVVGIDDLAIYVPKLYLDYKDFAEARGIDPQKLEYGIGIKKMAIADTNQDSACMAANACLKLMQKNHLHPEDIGRVYVATESSLDESKAMNSFVIGMLEQIYGEGSFEHAGGIECKFACVSGSYALYDNANWIRAEENNGKAAIVIVSDIAKYDMGSTGEYTQGAGAVALLIRENPRLMAYDPKVPSTTIKNEYDFYRPFGKETPLVNGSYSNLLYLISVRKAFDLYKEKAIKTGLIKLKDGESITDHIDYFAVHLPYRKMGEKALAYLLRHEWRHLPRWKHVIKEIGMQEPQPKDPRGTIESILADTEFMKADEQFRRAFMQTSFYNEVYEKKMASSLEASAIIGNLYTASMYMGLRSLLEFEFKKGIDLEGKRIGFGSYGSGSSAMVFSGIIQPQYKEVVSKMNLDEDIGPRQKLSMEEYERLHRNERTFKDSVIRAHKEFVLVRLGGNTADKAGFREYNYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK7</accession>
    <name>K0IJK7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15280"/>
    <dbReference type="EnsemblBacteria" id="AFU58462">
        <property type="protein sequence ID" value="AFU58462"/>
        <property type="gene ID" value="Ngar_c15280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15280"/>
    <dbReference type="HOGENOM" id="CLU_165890_0_0_2"/>
    <dbReference type="OMA" id="SIMHIAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1526-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="10369" checksum="709921E5789A91BD" modified="2012-11-28" version="1">MSLTNVGEIGEIMHLAKSGRLIVKLNAAGAGIRAGELLVDGSGKRVGRVAELIGPVSAPYASVIPMTDRTSRLVGSKVFSGGFAKMSRSQGRGSGRRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJP4</accession>
    <name>K0IJP4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60280">
        <property type="protein sequence ID" value="AFU60280"/>
        <property type="gene ID" value="Ngar_c33650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33650"/>
    <dbReference type="HOGENOM" id="CLU_3113195_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3365-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5471" checksum="0CD8E582E560C5FF" modified="2012-11-28" version="1">MSWVVYMIMIIDLGVAAAVAFPLLFIQSINTITTTFPADDPCTNFSCAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK02</accession>
    <name>K0IK02_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58612">
        <property type="protein sequence ID" value="AFU58612"/>
        <property type="gene ID" value="Ngar_c16790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16790"/>
    <dbReference type="HOGENOM" id="CLU_1431691_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1677-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="21704" checksum="415ED415010789D7" modified="2012-11-28" version="1">MIRNMTARTIFRNKMSLGEWIGRRFWESRQFYSAYIALFIAISNWITIQYRLLLENIPILNAMFSNIWVFLVVATVVFTILSILGGHYIHRKRQFRIEQAVAIEENPYLYRAAPGKERDLMIPMGILQLDATEAILRANNMLTDEKKKQIDAFKNELKKLSQGLPIGAVPAASTTTARQGVEKRDNALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK80</accession>
    <name>K0IK80_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58692">
        <property type="protein sequence ID" value="AFU58692"/>
        <property type="gene ID" value="Ngar_c17590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1734"/>
    <dbReference type="HOGENOM" id="CLU_170814_0_0_2"/>
    <dbReference type="OMA" id="NRWSAKD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1757-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12769" checksum="BA47353F5E6FD88D" modified="2012-11-28" version="1">MPTKEFMFKLKLSDEQSREFAMYLNSLSPSDLLFGLRFAYNRHAAASGGYLMPGRKSMVKRETHLLSQDQAKWRLNNWKAMIKTYREKGYSYPTISRIKKQVQKIAGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK3</accession>
    <name>K0IKK3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59813">
        <property type="protein sequence ID" value="AFU59813"/>
        <property type="gene ID" value="Ngar_c28940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28940"/>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2894-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20995" checksum="FB4BC12F4C634AC9" modified="2012-11-28" version="1">MSGDTTKHSTVTMTFRIEEGIMDVLRSESEKREVSLNTMVNQILRRYAEWDMYEPKVGMIPIARPLVSALFEHMDEKEIVEIACKVGKNAVHDIALFMKTRMDLQSFLSWFEMRIKTSSIEFSHSRLANGRHTYVIKHDLGYNWSLYHKTLLELIFNEILQKRIDITITPTTMTLMFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP6</accession>
    <name>K0IKP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59082">
        <property type="protein sequence ID" value="AFU59082"/>
        <property type="gene ID" value="Ngar_c21520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21520"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2150-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="21728" checksum="E78ADD20774E60B8" modified="2012-11-28" version="1">MDVRRDMSHTRTTPMRILIAEDELDIARTYRLSLEERGHKVVLTYDGEECLIGYHDALERAKSEGDPIFSSHPFHAVVLDYRMPKIDGIEVAREILAVNPRQRIIFASAYVKETLEKSVKELKQVVELMQKPFGEQALIDTIEDNQIYEELRKLDVDVEAFKMVSPPHEYIQKLLEALRTLQKGRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL30</accession>
    <name>K0IL30_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD-box ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Ngar_c32070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32070"/>
    <dbReference type="EnsemblBacteria" id="AFU60123">
        <property type="protein sequence ID" value="AFU60123"/>
        <property type="gene ID" value="Ngar_c32070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3193"/>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_2"/>
    <dbReference type="OMA" id="EHKDGQR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3207-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="216"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU60123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="454" mass="50187" checksum="764F97198D3AA840" modified="2012-11-28" version="1">MTKTFEELGLSAQLTRALSENGFEAPFPIQEAAIPLVLEGKDVVGQAHTGTGKTAAFGLPILQKIKPDGPLQALILAPTRELAVQVTTEIKRFAKYTGVRTVAIYGGQSINVQLDKLKQGVQIVVATPGRLIDHIKQGSIILDDVKFVVLDEADRMLDMGFIDDIKFILFYVNEDRQTCLFSATMPPEILRLAEEYMKRDEIEHVRLNEEEITLDTIDQSYLVVEEREKFKHLCNFIRQNKDSKAQTIVFAATKQRADRIAYNLRREGFSAVTIHGDLSQRQRDNAMHKFRKGTEDILVATDIAARGIDVPAVGHVINYDVPDDPNVYFHRIGRTARAGAEGKAISLVSNDRIADFDRILAQTQLPIRKLNDEMGIVVPVVAQRQPQSYGGGGGYRRRGGYGGGGDRGYRGGGRRYGSDGYGGYRRGGGHRGYGGSGSGYRGGGGRRYGNNNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA8</accession>
    <name>K0ILA8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">Ngar_c33680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33680"/>
    <dbReference type="EnsemblBacteria" id="AFU60283">
        <property type="protein sequence ID" value="AFU60283"/>
        <property type="gene ID" value="Ngar_c33680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3358"/>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_2"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="184"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="339" mass="37895" checksum="7D07E6062F510686" modified="2012-11-28" version="1">MPDRNHLSCKKCLLQPPSFDKAVVVVSDMPNPFFDKDIVSIKDFTKDDLEYVFESTDTISRLKHSERGELGKGRTLGYIFYEPSTRTRMSFEAAMASLGGSSIGIADLKSSSVEKGESLADTIRIIDLYSDVIVLRHPMDGSSRFAAELSQNPIINAGSGSEEHPTQALLDMYTMLKEKGRIGGLSIAIVGDLKYGRTVYSLLYGLANYDVDVHLVSPPTLQVRKESIYELQGRMKIKEHSELDEVLAEADVIYVTRIQRERFPDPQEYEKVKGTYTIDEKMLAKAKPDVAVMHPLPRLDEISHAIDHTKNAIYFKQASYGKELRAALLALMLNESLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE6</accession>
    <name>K0ILE6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00790"/>
    <dbReference type="EnsemblBacteria" id="AFU57029">
        <property type="protein sequence ID" value="AFU57029"/>
        <property type="gene ID" value="Ngar_c00790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00790"/>
    <dbReference type="HOGENOM" id="CLU_032903_4_7_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-79-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="44" mass="5379" checksum="E3D74F0CBEA0F9F7" modified="2012-11-28" version="1">MTLNYKFRLYPTKEQVLMLEQTLDGCRWVYNYLLDSVLPTYMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG6</accession>
    <name>K0ILG6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="6" type="ordered locus">Ngar_c34900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34900"/>
    <dbReference type="EnsemblBacteria" id="AFU60403">
        <property type="protein sequence ID" value="AFU60403"/>
        <property type="gene ID" value="Ngar_c34900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3492"/>
    <dbReference type="HOGENOM" id="CLU_146475_0_0_2"/>
    <dbReference type="OMA" id="PRKMKQM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="HYPK_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12606" checksum="030C4DA458FF508D" modified="2012-11-28" version="1">MRGGNREMRRMLDKMGLDMSTLDNVEEVIIKTDKKELYLIKPQVIEMKGKDSTIFQVVASDIEEKQREVPSFKEEDVILVMQQASVSREKAIQALTESKGDMAQAILSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH8</accession>
    <name>K0ILH8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57089">
        <property type="protein sequence ID" value="AFU57089"/>
        <property type="gene ID" value="Ngar_c01390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01390"/>
    <dbReference type="HOGENOM" id="CLU_3057240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-139-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6074" checksum="DC351CD28CB00B25" modified="2012-11-28" version="1">MNQLLVMFRCPDCGDSMKERIVITRLGDIDGWNCVSCDSFYSKKDMKKAILTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP6</accession>
    <name>K0ILP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59592">
        <property type="protein sequence ID" value="AFU59592"/>
        <property type="gene ID" value="Ngar_c26710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26710"/>
    <dbReference type="HOGENOM" id="CLU_2447767_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2671-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9830" checksum="929189DA57DCA409" modified="2012-11-28" version="1">MVVIIELVSMIIGNPATGAGSAAGMNPIDTVELVAIVIASIIFVYFAIIISLVSYRRRKEIEARAAEWRKGEEERRRRLREVLSELGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ0</accession>
    <name>K0ILZ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59812">
        <property type="protein sequence ID" value="AFU59812"/>
        <property type="gene ID" value="Ngar_c28930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28930"/>
    <dbReference type="HOGENOM" id="CLU_176750_0_0_2"/>
    <dbReference type="OMA" id="INIVEFP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2893-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12053" checksum="9CEF382AC7571214" modified="2012-11-28" version="1">MQHIGADQKCTFVAIADVELKRECIAEFKKWFSEVNSKILSHYKGFLGRVLIESPDGRHRIIIMAADKESFLAMRASRQHRELHAKALTFMTKPPSLSFYSIAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ2</accession>
    <name>K0ILZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59817">
        <property type="protein sequence ID" value="AFU59817"/>
        <property type="gene ID" value="Ngar_c28980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28980"/>
    <dbReference type="HOGENOM" id="CLU_2392990_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2898-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10651" checksum="8EF3240055E28B0E" modified="2012-11-28" version="1">MAIPDTTRIDLATYEGKYPTSLFNKGVRTQDEEHVGHVIKETGTRIIVDGHFDYRFVVPKEKIIAVGRNVILGMRFNDVFAYRVSRNDPLPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM23</accession>
    <name>K0IM23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57514">
        <property type="protein sequence ID" value="AFU57514"/>
        <property type="gene ID" value="Ngar_c05710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05710"/>
    <dbReference type="HOGENOM" id="CLU_3227950_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-569-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="43" mass="5263" checksum="B3F0125ABFA3A18C" modified="2012-11-28" version="1">MSDGKKIQNTLDFKAQVKKIKRLQRILSRKQNKRIPRVERRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM24</accession>
    <name>K0IM24_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">argG</name>
        <name evidence="10" type="ordered locus">Ngar_c29990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29990"/>
    <dbReference type="EnsemblBacteria" id="AFU59917">
        <property type="protein sequence ID" value="AFU59917"/>
        <property type="gene ID" value="Ngar_c29990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2971"/>
    <dbReference type="HOGENOM" id="CLU_032784_4_0_2"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="411" mass="45510" checksum="F442997A50733516" modified="2012-11-28" version="1">MGNSGKVVLAYSGGLDTSVCIRYLQTLHKLDVITVTVDCGQEDDFKEIEKKAKAIGAIKHIYIDAREEFAHDYVVPSIKANGLYQGKYPLATALARPLIAAKVVEVANREGVTAIAHGCTGKGNDQIRFDVTMRALNPKLKIIAPIRDMNLTRDVEMKFAKEQNIPISAEAKKYSIDLNLWGRAVEGGNIEDADFEPPEEAFQYINFQNDKAGYVEIEFEKGVPVAADGKRMPLIDLIQYVNDKAGAHGVGIVDHIEDRVVGIKSREVYEAPAAVTIIEAHKDLEKMVLTKHELAFKRMVDDQWSWLAYSGLWQDPLRNDLDKFIDATQVRVSGKVKLKMQKGSLRVVGRESKYSLYKNDLATYAAGSTFDQSLAKGFVELWGLQSIIANSVAADATTSSDKKQQQKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM97</accession>
    <name>K0IM97_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60127">
        <property type="protein sequence ID" value="AFU60127"/>
        <property type="gene ID" value="Ngar_c32110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32110"/>
    <dbReference type="HOGENOM" id="CLU_2165348_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3211-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="13112" checksum="6B4425CFAC9475C4" modified="2012-11-28" version="1">MKAVWEEYYKYKGKDWMEMKKAEMDQAIRDGTLREWVEYRSEPNNFANYNVYSYYYLNDQAPSISWYSFERNDFEPVITYWHVNPAGMVTLAGIGVAGTIATLYVFKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ1</accession>
    <name>K0IMJ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dpo</name>
        <name evidence="10" type="ordered locus">Ngar_c34170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34170"/>
    <dbReference type="EnsemblBacteria" id="AFU60332">
        <property type="protein sequence ID" value="AFU60332"/>
        <property type="gene ID" value="Ngar_c34170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34170"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3412"/>
    <dbReference type="HOGENOM" id="CLU_245200_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007869">
        <property type="entry name" value="Homing_endonuc_PI-Sce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05204">
        <property type="entry name" value="Hom_end"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="9">
        <location>
            <begin position="271"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="8">
        <location>
            <begin position="1313"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1578" mass="180148" checksum="E670D1C44A9BCA99" modified="2012-11-28" version="1">MPDRRKRLDDLPELPEGRPALLLSAVYSGEEKKVYLKFYDPKDNVIYHWRDRTDHKPYCYTKMQFAEQAELVAQKETKYTLEQVKKRDIIIDKEIDVLKVLAPDPLSIGGTDNSFREKVTSWECYDIATEILTKEGGWKSYYQLQDDEVVATYNATTRKFEWQQIETKVDYDYSGDMYGLHAKTIDFLVTPNHRIFLWNERGDVKCMLAKELYEQQEQLRPNYRPFPFGWSIHKSAESGFDGDADIDRFTLPQSSWRCSEVDIPLEEFVEFLGWFIAEGGVGGLGNETYINLILSTDKDPWQRLKHMIESWGMKVWTKNNNDTHSTMIIFSSKDLADWIRANCYTCSIHRSHYKRVPAAIKNLPTRYLKIFLKNLFLGDGFLRDGDSGQLRTTSEALADDIQEIACKCGYSATIKQKPAIVDNRGWQFAESYVVTLSTHRTVTSPNQRITKQQYVGKVWCVKVPNGIVYVRRNKKPYWCGNSDIKYHENYLYDRSLIPGLYYMRKGEQITPFEYPISEKVQFALKSLLWDKIKEAGESGKEYRQYITNWANLLNQPIPELKRVAVDIEVETEEGRMPNPRDHDKRVTAVGFVASDGFRKVLVLANNTPNNGEPLIPEAEPCSTEKELLEKAFRIINKYPIVITFNGDDFDLPYLYARSQDSRIDPNGVAIPKDKVPIMVKKESFIKHGMQAEPVGIRHGIHIDLYRTFDNRSIQIYAFSRAYTEHTLNAICEALLNDSKIEFEGDIADLPIQKLAEYCLKDADLTYRLTSFNDNLLMRLLVVISRIGRLSVDDIARFGVNQWIRGILYYEHRQRNELIPSRSELEAKGSASTTAVIKEKKYRGGEVVEPTAGIHFNVVVLDFASLYPSIIKVHNLSYETINCPHEDCRENKVEGTTHWVCKRKKGLTSLLIGSLRDLRVNYYKYLAKDKTLPPQERQLYNVVSQAIKVILNASYGVMGAEIFPLYCLPVADATAALGRSTINRTINRCKEIGIEVVYGDSVLPDTPIVIRRKDKSIDIVPIESLMPKTVTASRYVGFGNIEVLTESGFSGIKYVYRHKVKKKGYRILTRKGFVECTEDHSLVVNNKEIKPSELRIGDRIELVPFKTQSLFGIDPDLAWLFGFFIAGGTCGTYYYSPASETASKTLQIKYSWKIANQNEAALMKAQRIMQQHLGLETNVIDTRKSSATYALVPRKEIKMLVDYFRLLCYRGSNKAIPQCILNANIEAKKAFIEGLMVGDGNMDENGLVTLDQIHKTVSAGVVAILEELGMEYSLQIRDDKTNVCRIRIIKDASDKRIKQADIIKKIEVFEIDDYVYDLETENHHFCGGIGNVLLHNTDSLFLKNPSPTAIDEVAAWARNTLGVDLEIDKQYRYVVFSDLKKNYLGVLSDGTVDVKGLTGKKSHTPPFIRKAFYDILAILGRVNSEKDFESAKESIKNVILQNAKNLEARKIPLEDLSFNVTINKSLSTYGKKTGAKTVDGRSTDTYKGLPQHIKAAKMLVDANKREIRAGDVISYVKIKNGEGVKPVELAKPEEIDTEKYLETMESTFEQVLSALNFDFKSVLGKPRQQSLDELFWSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ4</accession>
    <name>K0IMJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60342">
        <property type="protein sequence ID" value="AFU60342"/>
        <property type="gene ID" value="Ngar_c34270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34270"/>
    <dbReference type="HOGENOM" id="CLU_202920_0_0_2"/>
    <dbReference type="OMA" id="DMSYGEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3428-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6341" checksum="699536E781527361" modified="2012-11-28" version="1">MKVRCPDCKGVAEMADDFTFVKCGNCSFDMTYGEYVKYIAYKDSRYRDILSDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK3</accession>
    <name>K0IMK3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c10220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10220"/>
    <dbReference type="EnsemblBacteria" id="AFU57964">
        <property type="protein sequence ID" value="AFU57964"/>
        <property type="gene ID" value="Ngar_c10220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.973"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_2"/>
    <dbReference type="OMA" id="FATTQQM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1020-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="90"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="395" mass="41913" checksum="E644010CAA742DB9" modified="2012-11-28" version="1">MAKREKEGHQKMIATVQSSSDEERIADLNEFLKEIAGGNLMKDVARDGDGIIGELQKNIGNAVAGFRNVVSQATAASNNIISTSTELANATDQVNTSVQQISTTIQQIAKGSQQQAEEIDAINKLTEDLDGGMKKLAVKMAKAADMSASVGKASSIGSRSATAAEEKIARIINISHDSAENIRNLADRCDKISSVLDVIRKIAGKTNLLALNAAIEAARAGEAGKGFAVVANEVKDLAEGTAKSSEEIEAIISKVQQDARHTVETIEVGMKEIAEGRIVINKALQALEDIAKRAQMVDGTIKELSILLQSQVSAVSEVSKRAADIASVAEENAAATEECAAATEEEAAGMQEISNAIHDLNSLGRSLQEMLSRFKVPNHIVEKIQQSAEAENRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMS8</accession>
    <name>K0IMS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58154">
        <property type="protein sequence ID" value="AFU58154"/>
        <property type="gene ID" value="Ngar_c12140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12140"/>
    <dbReference type="HOGENOM" id="CLU_172988_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1212-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="9927" checksum="84024D1A148F8831" modified="2012-11-28" version="1">MSQKNATSSQQDIQQSASQWSEIIGQLFDRLTGKGASVTYTFDNLVIDMPRAQGPGGQDIGSAKWTVNGKIVITAEAHRMEEAGQRASVSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMS9</accession>
    <name>K0IMS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58159">
        <property type="protein sequence ID" value="AFU58159"/>
        <property type="gene ID" value="Ngar_c12190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12190"/>
    <dbReference type="HOGENOM" id="CLU_160433_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1217-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12590" checksum="FCB4973AF93D5BC7" modified="2012-11-28" version="1">MSEETPISGPSSSSRFVCKVCGNTFDRRDVLNEHIAEAHHQKRTVTVNDIVNGVFEGKINLPKTKAEIVQYVEENKDKPAVTPEVIQVVKNMPDKQYFDEADLAYGIEQGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW2</accession>
    <name>K0IMW2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secB</name>
        <name evidence="12" type="synonym">secG</name>
        <name evidence="14" type="ordered locus">Ngar_c13820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13820"/>
    <dbReference type="EnsemblBacteria" id="AFU58319">
        <property type="protein sequence ID" value="AFU58319"/>
        <property type="gene ID" value="Ngar_c13820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13820"/>
    <dbReference type="HOGENOM" id="CLU_208205_3_2_2"/>
    <dbReference type="OMA" id="VIAHILY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU58319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="5888" checksum="F4A4B1C171DD337C" modified="2012-11-28" version="1">MSSKKKNAPLPASSAGLLRFFEDETRGIKVKPEIVLGITGAVIAASILIRILLPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ3</accession>
    <name>K0IMZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glucosamine-1-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.157" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15400"/>
    <dbReference type="EnsemblBacteria" id="AFU58474">
        <property type="protein sequence ID" value="AFU58474"/>
        <property type="gene ID" value="Ngar_c15400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15400"/>
    <dbReference type="HOGENOM" id="CLU_055419_0_0_2"/>
    <dbReference type="OMA" id="SNKGHDG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1538-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023917">
        <property type="entry name" value="Bifunctiontional_GlmU_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13562">
        <property type="entry name" value="NTP_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03991">
        <property type="entry name" value="alt_bact_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="421" mass="45710" checksum="615EDD4CEAC1200B" modified="2012-11-28" version="1">MGIALFEDSHWQNFSPISLTKATFDIKVGARSFFEEHQVMPEVLLTREYLAGVTSERHVRCRVNPSSIDADTVFVNGLLHPGTIFPDRLQKVGHTFAITAGDRLLVARLGRKGIEYLSDCVAAGKNIDVRKLDVEKSTKLKAEESQGLLSEPWDIITLLENSLALQTSKMQGESDLGPGVRVAGNHAIAIARNASVEEGTVLDARQGGIYIGPDAYVATSRIVGPAYIGGMTQVKQFTIIESSFIGHNCRVAGEIEHSVISDHTNKTHAGFIGHSYVGEWVNIGAMTTTSDLKMTYGSIKMASGGGKTKVDTGQNKIGSFIADMTKTSIGTLIYSGRRIGTSSHLHGLVAQDVPSFTIYGSSIGATNTELELCSAIETQKKMMSRRNQTMSKAYEQMIKDVFSMTATERKRAGVRKAKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ7</accession>
    <name>K0IMZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC efflux transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c15600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15600"/>
    <dbReference type="EnsemblBacteria" id="AFU58494">
        <property type="protein sequence ID" value="AFU58494"/>
        <property type="gene ID" value="Ngar_c15600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15600"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="ICGFDVQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1558-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="309" mass="34053" checksum="2CFA3475D46EBF42" modified="2012-11-28" version="1">MLAIDAASVTKIYKDARQAALSDVSLKVEAGTIFTLLGRNGAGKTTFVRMCATQLMPSSGNIRVLGYDVTSQAKQIRELISIVPQEGRPLRALTSWDHVYNWLQIRGENKQTAKEKTEEILRKLELYEARDKPAMNLSGGMKQKILVAMAMATDAELLFLDEPTIGLDPVSRRQVWSAIKDWKSKGGSILLTTHYMDEAEMLSDYIVIIDRGTVIAQGTIQELRKVIPQNIRVDIARDGLDVDVLRSYGSVVDTGAGMLRVFTFESAVRELSELALRKNLAFTVSPVTLDDVFVYLAGGGIGDDQNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN59</accession>
    <name>K0IN59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative streptogramin lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18720"/>
    <dbReference type="EnsemblBacteria" id="AFU58804">
        <property type="protein sequence ID" value="AFU58804"/>
        <property type="gene ID" value="Ngar_c18720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18720"/>
    <dbReference type="HOGENOM" id="CLU_505894_0_0_2"/>
    <dbReference type="OMA" id="EARITEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1870-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="450" mass="49186" checksum="3A92C81F92C2105A" modified="2012-11-28" version="1">MPVGIAADGSSQVWYVSAKRGLLGSYDVAENRFNEYNIPEWPTREQPFTNLGSWQMSWTVKANGDYVWFTDQNNAIWRFNKASESFDVFRVPARYPSDMEFDANGNIYLIGINSKSIFFGDVSKMKSGTSEGFTEIPLPLEGFEGVSGIVTSGLLVLDEQRNDLWVSLLSFQQKGQLFQYDIDTNSFVRTVDLPASLSSPVGATLDNSGNLWVTDHGTNIFFKYDPVADEITKFVTSIASPKIFGGTTPANAQTWPYWMATGPDGSIWFNEHTGNKMARFDPENLVLTEYWIPSQNKNWAACPPGSDTCGIANVLQFAVGQDNQAWFSEWTENKIGRLDAAKQVPISVSAPDGEVTVARGDSTEIRVTIDASGDFSGKMMAAGTFTPNSMLGNSTGIFSEESVSISGGGSKQVSYVFMPAEDLAAGQYVIMIGAGNDDVSVLKAVRVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND5</accession>
    <name>K0IND5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59184">
        <property type="protein sequence ID" value="AFU59184"/>
        <property type="gene ID" value="Ngar_c22540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22540"/>
    <dbReference type="HOGENOM" id="CLU_2083871_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2252-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13337" checksum="8F13A442562BF768" modified="2012-11-28" version="1">MSKADLYQRLDRVSEITLTVKGRKSGRDIHRPVWFVHEGNTLYLLPVQGTDTNWYKNFQVNPTLKISANGAETTVRGKPITDSDRVDYVVSKFKSKYGEGDVKKYYPKTDVAVEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING9</accession>
    <name>K0ING9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c24300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59354">
        <property type="protein sequence ID" value="AFU59354"/>
        <property type="gene ID" value="Ngar_c24300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2400"/>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="FIIGPHT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2428-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="16"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="410" mass="43105" checksum="D36E40F15E59D9B0" modified="2012-11-28" version="1">MAVESTFLHVMISLGILLFAAKLMAELFHRIRLPVVLGELLAGIIVGPFAIGALPLFNGEPLVILDETVRHIGEIAAVVILFVAGLHITPREFMRGGAASFTVGSLGVVVPFFVGHYVFTAFGLEALQSMLVATALTATSIAISIQVLTELGRMQSKEARLILGAAIVDDILAIAALSVVTTMVQTGNVAPDVIEITMLILYILGIFAALLVGAVFLVPRILHVERLWKSKGSIEGMVTAVFFAAAGIAAFAGLSPIVGAFAVGMAVASTRVIKQIEEYVGKLEIIFAPLFFAIIGAQVDLRGVNLGVLYITGIIVAVAVVTKLVGCGLPAMIFLRNKNKSMKVGIGMVSRGEVGLIVAGVGVSAGVLSADIYTAVIIMVAATTIITPIWLKMAYRKDPPEPAAVVEKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH1</accession>
    <name>K0INH1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="7">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">leuS</name>
        <name evidence="11" type="ordered locus">Ngar_c24400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24400"/>
    <dbReference type="EnsemblBacteria" id="AFU59364">
        <property type="protein sequence ID" value="AFU59364"/>
        <property type="gene ID" value="Ngar_c24400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24400"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2413"/>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_2"/>
    <dbReference type="OMA" id="AWNMAFQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="13"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="709"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="635"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU59364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="971" mass="109824" checksum="B0C00C11A3333F3D" modified="2012-11-28" version="1">MTFLIDWGFIEEKWIKRWEAQKLFEADPKDGRKKYFVTVAYPYPNSPQHIGHGRTYTLADAHARYMRMKGYNVLFPMGFHYTGTPILGMSRRVAAGDAELMDTFHRIYKLSDDVISTFVEPVKIASYFHNEIKAGMKEMGYSIDWRREFTTIDRMYSKFISWQFHTLRKKGLIVQGSHPVGWCPRDQNPVSQHDTMGDVEPDFNEYTVVKFRSGDGNNNIILPAATLRPETLFGVTNMWVNPDIDYVQARVDGEEWIVSRQAARKLEFLNHNVEIMKMVRGKELIGQSAINPVNNATVPVYPASFVEADSGTGIVMSVPAHAPYDYQALEDLKKDKKTQQEFGISINVDPIIIIESEGYTGVPAGQAIEQVGATGQNDAKLEKATSDLYSHEFYKGKMLENTGRFAGMAVAVAKNEVKQDIVQSGAADTMYELVNKPVRCRCGAECVVKLLSDQWFLNYSDKEWKRLAHECASKMDIVPQDIRQEFDYVIDWLRERACARKSGLGTKLPWDQEWIIESLSDSVIYMAYYVIAKYVNNKMLSDNDNSITDAFFDYVLLGIGNADQVAKECKVPASTVEQIRKEFSYFYPVDSRHSGRDLVPNHLTFFIFNHVAIFEKEKWPQQIVVNGSVLMEGKKMSKSLGNIIPLRAAIREHGADTIRLAMLVSAEILQDADFSFDTVRGIRSKLLGIFEMAEKCKNQQAAAGAELEDRWLASRLQRAIAETAASMDRLRVREAIHNILYSLEQDLQWYLKRTAAKGRENVTGTLAEFLDVQVRMLAPFAPFTAEEVWERMGNHNDQSITAAGWPAINEDKIDPVAEESEFLISSLLTDLQNIVKVTKITPSKVAIYTSAGWKAQVYRAILANILAGKTNFGEIMKQLIANPETAKAKTDPKMVQKMMEDILSTPLEARNRRLNLTAFDEAAAIKDAASLLSADINKAQIVVYSEEDASKYDPKSKARSARPFKPAVYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI5</accession>
    <name>K0INI5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25110"/>
    <dbReference type="EnsemblBacteria" id="AFU59434">
        <property type="protein sequence ID" value="AFU59434"/>
        <property type="gene ID" value="Ngar_c25110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25110"/>
    <dbReference type="HOGENOM" id="CLU_2748323_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2510-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7808" checksum="19CA20EA7A662B5A" modified="2012-11-28" version="1">MDRVRDWVLRLRPTAAESDMPSAHLVARIAMVRTDGTAMHDHAISNFGLTNVATEDNNTTTVFRGQRPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN0</accession>
    <name>K0INN0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mercuric reductase</fullName>
            <ecNumber evidence="6">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">merA2</name>
        <name evidence="17" type="ordered locus">Ngar_c27380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + Hg + NADP(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27380"/>
    <dbReference type="EnsemblBacteria" id="AFU59659">
        <property type="protein sequence ID" value="AFU59659"/>
        <property type="gene ID" value="Ngar_c27380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2716"/>
    <dbReference type="HOGENOM" id="CLU_016755_1_1_2"/>
    <dbReference type="OMA" id="VEHIWAM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045340">
        <property type="term" value="F:mercury ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050787">
        <property type="term" value="P:detoxification of mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021179">
        <property type="entry name" value="Mercury_reductase_MerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02053">
        <property type="entry name" value="MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="9"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="15">
        <location>
            <begin position="347"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFU59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="472" mass="51209" checksum="080837A331ADBE1D" modified="2012-11-28" version="1">MAIMKNGEYDLIIIGGGAAAFSAAIKANMHGVKTAMIERAALGGTCVNVGCVPSKNLLGVGEMLHSAKKPPYPSVFPCDSDFDFSKTIEAKDALVKGLRKQKYYDVLQSLEHVDLVEASASFVSPKKLKVDGKQFEANKFIIAAGSSPSVPRFKGIENVKYLTNNEALALKEKPSSMIVIGGRALGLEFAQMYARFGTTVTVLQRSDRIIPEHEPEISQGLHQYLTEEGIEIVTGVNVQEVWQKNGSRFIKVSVNKQERVFEAEQLLMATGRRPNTADLHLENAGVKLREDGAIVVNSEMRTSAPHIWAGGDVVGEPMLETLAAKAGATAAENALTGSHKKIDLLSVPSAIFTSPQVANVGMTEKQMMQKYNYCSCRTLSMKEVPKALTVNDTKGLIKMAIDPKKNNRIVGVHILASIAADMIHEAVMAIKYKLTIDDIIDTVHVFPTMSEAIKLVATAFKQDVSKLSCCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ6</accession>
    <name>K0INQ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c28700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28700"/>
    <dbReference type="EnsemblBacteria" id="AFU59789">
        <property type="protein sequence ID" value="AFU59789"/>
        <property type="gene ID" value="Ngar_c28700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28700"/>
    <dbReference type="HOGENOM" id="CLU_982176_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2870-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="3">
        <location>
            <begin position="224"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="334" mass="36711" checksum="384FEC6D899C5A60" modified="2012-11-28" version="1">MPVCTDYFVPGSKFWNDNIGQIVHEILLRKNIRGLLPLFAIVGGFLVVGAILISSGILPEERAREFRPLTYVSMPSDMKVIQEPTLDENVFIYAINDVAQRGIDIAQRDARVRQILDETTDRKAAVTIAAVQPTVMEDRQSGELLYSSIGQVIITANWQVVDGAPYSEPKNFAEIANKKLESRQQIWHVLVDVDDGQVTQVVQQADRVISDVVKPNLVRADVNMFVPNAIMVDASSTVRWPNSSNLPHNVVGIFNKTAAPDAQGSTGLIPDNNNSTSSSTNDAQSPSVIAIDSGFIQPGRSWQYRFDEAGVFNYLCTIHAEEGMRGTLIIAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW5</accession>
    <name>K0INW5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c31680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31680"/>
    <dbReference type="EnsemblBacteria" id="AFU60084">
        <property type="protein sequence ID" value="AFU60084"/>
        <property type="gene ID" value="Ngar_c31680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3147"/>
    <dbReference type="HOGENOM" id="CLU_000688_8_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3168-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="117"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="390"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="530" mass="58003" checksum="2D0940B473784BAC" modified="2012-11-28" version="1">MAPTEPLRILGAEEYLAGFLEDQLVTRGDTIPLNIMGQRIDLVVAGTNPSGPVIINASTQVTLSEEVAKAAAAQEGGIPAITYEDIGGLRDVVTKVREMIELPLRHPELFRRLGVEAPKGVILHGPPGTGKTLLAKAVANETNANFYTIGGPEIMSKYYGESEERLRNVFQEAQKNAPSIIFIDELDSIAPKREVVTGEVERRVVAQLLSLMDGLTARGKVVIIGATNRINAIDPALRRPGRFDREIELGVPDRNGRLEILQIHTRGMPLADDVKLEKLADISHGFVGADLQSLAKEAAMRALRRILPEIDVSAESVPAETLNKIIVKMQDFMDVIKEMEPSAMREVFVEVPDVKWEDIGGLEAVKQEVREAVEWPLKYQGVFAYADATPPKGILLYGPPGTGKTLMAKATANESEANFISIKGPELLSKWVGESEKGVREIFRKARQAAPCIIFFDEVDAIAPTRGGGFGDSHVTERVISQMLTELDGLEMLTNVVVIAATNRPDIIDPALLRPGRFDRLLYVPPPDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX1</accession>
    <name>K0INX1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c31980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60114">
        <property type="protein sequence ID" value="AFU60114"/>
        <property type="gene ID" value="Ngar_c31980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31980"/>
    <dbReference type="HOGENOM" id="CLU_065303_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3198-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="238"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="330" mass="38106" checksum="43C5AFB1DF3E56A7" modified="2012-11-28" version="1">MDEVCSAWQDMIKVKKPYSGNRKMHPEVYSKYASHASIAEPNDPVYLDTQRMFKVIKTDNKMPYFVAITVKPRLRIWCPIKTKQYIEGNIHDSKLLKRDGHYELYLTISKEVSFDNAHPSSILAVDMGERNIATAVLFANSFTSNQSKPIFMGRNVRGLRRKYAYLRKKLGKKKLLRMVRKVSNREQRKVNDILHKISRQIDDVAKENNAVILLGDLSGIRNRTRSRRFNRIIASMPFYRLTKYIAYKANWEGTPVLTTREWYSSKLCHRCGSDNTLRPHQGLFVCHACGYQCNVDYNGAFNLAKRLGKLSSLTALSGSSAKIERLFVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX9</accession>
    <name>K0INX9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60154">
        <property type="protein sequence ID" value="AFU60154"/>
        <property type="gene ID" value="Ngar_c32380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32380"/>
    <dbReference type="HOGENOM" id="CLU_1113906_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3238-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="28134" checksum="0619F4D7F91DA0F1" modified="2012-11-28" version="1">MKVESDAPHEKSSALKEEAKAEDSVVVVKEKQVISGDGKTAQILVEEEEEEQEALSAADFHNNDNKILAVLNETGSNYSFKGLMRKLNLHQQSLSRALHRLEGMGLVEKSLVGYRLSRTGESAISKFDMHRPKGREYMQLLQTYIPLNVRATEIIRQLVGKWFKNLRWLGMIESGTGYTLQWSSDDGSFQINLRLISDYIVIETNASTEKEKVEAMVGSYAIYEQITKAMQSKLGAYMDRQQLGHSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ9</accession>
    <name>K0INZ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60254">
        <property type="protein sequence ID" value="AFU60254"/>
        <property type="gene ID" value="Ngar_c33390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33390"/>
    <dbReference type="HOGENOM" id="CLU_2949428_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3339-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6941" checksum="D23020111FBC5620" modified="2012-11-28" version="1">MIVYEQTRFSQFINTIDGINPKTLTARLRELERNGMIGRRCIQKCSGELNISSTKREWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7S2</accession>
    <name>K0I7S2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57311">
        <property type="protein sequence ID" value="AFU57311"/>
        <property type="gene ID" value="Ngar_c03630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03630"/>
    <dbReference type="HOGENOM" id="CLU_2985795_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-363-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6631" checksum="8EC0B36343DB2DD1" modified="2012-11-28" version="1">MKLAKCKLCKKVHKGIGDFCPTCLRIKRMVRKIPKGQRDKIKRAIKKGRISIRRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7Y1</accession>
    <name>K0I7Y1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppdK</name>
        <name evidence="10" type="ordered locus">Ngar_c04290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04290"/>
    <dbReference type="EnsemblBacteria" id="AFU57376">
        <property type="protein sequence ID" value="AFU57376"/>
        <property type="gene ID" value="Ngar_c04290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.412"/>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_2"/>
    <dbReference type="OMA" id="HFFHEVG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="8">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="8">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="7">
        <location>
            <begin position="423"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="9">
        <location>
            <begin position="521"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="895" mass="98491" checksum="396D35E8684F4609" modified="2012-11-28" version="1">MSEEGFGKAPAIVKPIYFFDEADGKNKMLLGGKGAGLAEMTRLGLPVPPGFIITTEICEKFYEAGRRLPDGLMDEVRRSISRLESLTGKKFGDPQNPLLVSVRSGAPVSMPGMMDTILNLGLNDETVEGLSRKSNDPRFAWDAYRRFIQMFGKIVLGVDDRKFDSILAGKDLSNPKVLKDIAMSFKSLCEGTGGKKFPADPYKQLELAIDAVFRSWTGKRAVEYRKQHNITPDMAGGTAVTIVTMVFGNMGSDSCTGVVFTRDPETGEKQLYGDYLINAQGEDVVSGRATPNHIDSLVSEMPDVYQQLLGVCEKLESHFKEPQDVEFTVEKGRLYILQTRAAKMNAVAAVKTSIDLYHEGLITKTAALERIDPEGLEQILYRRIDPHVKQKAIATGIGASPGAASGIAVFDVAQAEALGKKGEKVILVREDTKPDDVPAFFQSVGILTSRGGKTSHAAVVARGMGKPCVVGCSQIEIDAEGKSFSVGGKKVVVSEGQKITIDGSTGRVYVGEIPTVEPEISSEFKELLQWSSEMKGIKIRANADTVESAALARKYGAEGIGLCRTERMFNQHDRIMQFVSMIMAENEEERRRALAELEPLQKSDFKAILREMNGLPVTIRLLDPPLHEFLPKEEDLMQKIFELKSSSAKPSEIARIEKILHRVHELSEINPMLGHRGVRMGISFPEIYETQIRSICEAAAELAKEGVAVEPQIMVPQVGLVEELAAVRQIFESVKREVEHRHRIKLKIKFGSMIEVVRACLVADDIAHLVDFISFGTNDLTQATFSFSREDAEGKFLPFYLEKGIVSVNPFQSIDRKGVGRLMKMAVDMARKEKKDIEIGICGEHGGDPRSIEFCSTAGLDYVSASSHRIPIAILAAAQSAIKQNKRLHRHSTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9E5</accession>
    <name>K0I9E5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57966">
        <property type="protein sequence ID" value="AFU57966"/>
        <property type="gene ID" value="Ngar_c10240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10240"/>
    <dbReference type="HOGENOM" id="CLU_1870805_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1022-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="14876" checksum="5137A6E319345BE7" modified="2012-11-28" version="1">MVDEFNAGIALAIATMASPVLVYFVLAGLPSTATASQISGRLESQIEGLGVQIQDGDLDYLNDINFKNSNPEERLRIAYERSAQVEVNRCLGDSQNKEMCKDTMALLVDSCTDSSMYVAACDDPRLANYRTTNLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9S5</accession>
    <name>K0I9S5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LEA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58076">
        <property type="protein sequence ID" value="AFU58076"/>
        <property type="gene ID" value="Ngar_c11340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11340"/>
    <dbReference type="HOGENOM" id="CLU_1536714_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1132-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEA_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="153" mass="17159" checksum="4B88B805984CD9B1" modified="2012-11-28" version="1">MNYYTLNNLQFRGNTAESIDFATLSMDMKIDACNPTPIPTRFDKFTIAVNYRGEEFATMMINGKTIPPYQTTILDGRMSVNGEAFAGLFMKTLADGLAGRQGQSFEQEEDMTVVTTIDSRALGFIPISDRKSLAMSEFQQQMQQDDEDQFSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA76</accession>
    <name>K0IA76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58221">
        <property type="protein sequence ID" value="AFU58221"/>
        <property type="gene ID" value="Ngar_c12810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12810"/>
    <dbReference type="HOGENOM" id="CLU_2712964_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1279-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8497" checksum="90EEF44812C0963E" modified="2012-11-28" version="1">MTKSINKHRLRIEEFDRPISVPRATDDYSLDRFVHCTVCDNFAYCRVSEDTNLVIRVNYYCKNCVSKFSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAJ2</accession>
    <name>K0IAJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58336">
        <property type="protein sequence ID" value="AFU58336"/>
        <property type="gene ID" value="Ngar_c13990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13990"/>
    <dbReference type="HOGENOM" id="CLU_113587_0_0_2"/>
    <dbReference type="OMA" id="INHSAME"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1397-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="218" mass="24575" checksum="73BB771537209C7E" modified="2012-11-28" version="1">MDLERFTADVTSLSGRMSAGESEEVVQRMDFVKNRLIDLYSRNLVKINHSAMELVCAKHLIHYGYQVDVEKQLTDILVCDVYAEKGDGAAIVEIETGFIPPEHALDPLSYYAARIASKIGRYSKYANKFVLATPPVSVLPIPELFRRPPKDRRASEIKEVKALCDRYYKNPPVTEDEILNGRLHVIYIINIDAGKVVEMDVDSYFDQVGGMLSTGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAL6</accession>
    <name>K0IAL6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58366">
        <property type="protein sequence ID" value="AFU58366"/>
        <property type="gene ID" value="Ngar_c14300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14300"/>
    <dbReference type="HOGENOM" id="CLU_2490576_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1428-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="9881" checksum="71DD6CADE4E45F06" modified="2012-11-28" version="1">MASARRYLYVGVIILSVSGAIAIYLNFQGVRCLSDLALVDRSVLAPTQLEEMERNCSIVTNSYVYSVYGVVAGIMLVVIGFMRKRKGNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBJ6</accession>
    <name>K0IBJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/ribitol dehydrogenase family protein</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdr3</name>
        <name evidence="2" type="ordered locus">Ngar_c17180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17180"/>
    <dbReference type="EnsemblBacteria" id="AFU58651">
        <property type="protein sequence ID" value="AFU58651"/>
        <property type="gene ID" value="Ngar_c17180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1692"/>
    <dbReference type="HOGENOM" id="CLU_461282_0_0_2"/>
    <dbReference type="OMA" id="EQRPYRF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="605" mass="65595" checksum="70D99E36AF7F8DA2" modified="2012-11-28" version="1">MEKQSSLKSNLKFSGKTVVITGSGTGIGQAIAKKFAENGANIVIMGRRKEPLDQTASMLNKIIASAGSSGKVVVFPRVDVADEAGINAMFASLKNQFGKVDIIVNNAGVSGPVKTFTNASVKEFREAVAIHLTGTFWTSVSGLSAMERGGKIITIATFFTEENRYEQRPYRFRTPYTAAQGAKNRLAEALAWELVERDIRSISTNPGPVHSDRIYKTVYPKAAAEFLRIGGYPGLSSIEVEKVTAGALPLLGEQDEVVANGCRQVAVEIAKARGQEESEENIKKLSETVAGALAKMQEIAEKIQNNTSKMIVDGEFLTQEDVAEMVMNLCDEKISKLINGRVIPNDRVFYPVKPIVGTSVDGPAQPDLKDKVIILTTSSSAKKDIERVKQVARLAQGAGAKQVIVLANNQSDMQEYRDFHNHAINMLDEESVRRIFNTARTKFGKIDSVIHFTGDYDYNAAFSSLSRSQWDALVNNFIYIPGLITKEAVNAMAPQGAVEEPAKYKDSKGTVVIVGPDAPVGKKISGVLRARADVFRGALRPYTATVNQELGDVLGSSIKLHLVLAGNSEGSEPDAARLHNSILNLAAGVALKRNEAIFYVDEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBP0</accession>
    <name>K0IBP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56990">
        <property type="protein sequence ID" value="AFU56990"/>
        <property type="gene ID" value="Ngar_c00400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00400"/>
    <dbReference type="HOGENOM" id="CLU_2857201_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-40-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7063" checksum="F91400BB228C878C" modified="2012-11-28" version="1">MSSLTIEQKLTAKQRLEIEARLANYNIPVQILQMVAARCECTLDPKVSGRGLPKSPSCLFCLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBS5</accession>
    <name>K0IBS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58716">
        <property type="protein sequence ID" value="AFU58716"/>
        <property type="gene ID" value="Ngar_c17830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17830"/>
    <dbReference type="HOGENOM" id="CLU_2581536_0_0_2"/>
    <dbReference type="OMA" id="DRHFERE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1781-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9313" checksum="C1D9635DA1A38CA6" modified="2012-11-28" version="1">MVFDSLIGQIGPAYDPLFYDVMVYIFGTMLFAVFLLGVIAFWLRRKGLGGGSAKEKWAQELERYFEREQIGLIPDEKHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC72</accession>
    <name>K0IC72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20240"/>
    <dbReference type="EnsemblBacteria" id="AFU58956">
        <property type="protein sequence ID" value="AFU58956"/>
        <property type="gene ID" value="Ngar_c20240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20240"/>
    <dbReference type="HOGENOM" id="CLU_092291_0_0_2"/>
    <dbReference type="OMA" id="GSDWAFN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2022-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="210"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="263" mass="29320" checksum="5E81A7872D56C69A" modified="2012-11-28" version="1">MKQQAEERQLKVGDFMSSPVVTVRPNTNFVDAVQVMILKGIGNLVVVEGERVDGIITERELLQHLVLNKTVTNKQVRYVLTQKFTKINRETSILEAAKTMISKKARLLVFEKERRTGADQLVGIITASDIVRAFLQTDRNPSIESAMTNRIFTIKPDNTILAAAKMMLKKGIGSVVVTTNGSPYAIFTERDLLRVLGQRIDIEERVGAYCTYPVVTAKLGIGAKDAAKIMFSRKIKRLPLTKGDEIVAMVTARDLVEAFQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICN1</accession>
    <name>K0ICN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04430"/>
    <dbReference type="EnsemblBacteria" id="AFU57390">
        <property type="protein sequence ID" value="AFU57390"/>
        <property type="gene ID" value="Ngar_c04430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.425"/>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_2"/>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-442-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="157"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="369"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="857" mass="95182" checksum="B91F6F3DB2D39D66" modified="2012-11-28" version="1">MSVVNYRCPKCSSPHSVGVDKIFDGRLIFRCAKCKICSIVPAPGSIDEAYLDFLDRFESGSGVADASDLKLLMEQERIIRPAKEIDALMASANAAGDPLLEDLLRSQQDYVVDFQAIEEPPPEFGSNIEDLPVDEAIISALKAKKIERLYSFQEQAIRKILQGNDVVITAPTASGKTEAFCIPVLQKIAEELPRFGSLRTGEGSSKVSAIFIYPTKALSRDQLPKIKELAEPLGAMVAVLDGDTPEKERTSIMDSPPDVIVTNFDVLHYHMMHRTKFSRMIRTARFLVVDEAHVYTGVFGANVHHIIARLERLAGRKLQVIAASATLPNADEFCQTLFGRKMHIVQGRGRRGRINLAIIFPSLRSYRSLALDLLRQTTKRKHKTIAFASSHLGSELMAFYGSRQGVSIRVHRAGLPPALRKEIEQQFKSGQLAAISATPTLELGIDIGDVDAIISNIVPVNRLTQRIGRAARRGQQGYAFLALGNDPISQYYKMHPADYLADHEYAYTDPANPFVQEYQVLAMACDRPLSMAESKPVWNVLQKLVSKGVVKTVRERFVPDLKQAMKMLNEYSIRGIGSRVDIKFNKKIIGDRSLPQALEELHPNAIYFLAGRRYKVQELHFEPNSQPYAELAVIPSDYPYYTKALTDEWPSILEVYEKKVVFGIEVAYCALKIQKRVLGYANIEIGQEVVQGKKVVLDKPLEFEFVTKGSVFRAPRPVDILQKVDDEQYVEMSGFHASEHVIIEGSAMITGGASQDLGGISLGSSGLIFVYDGSIGGNGASRALFDRLDKAFGRALRILSECPCKSESGCPRCTYSYRCGNNNEYLHKLAAIEVMNRVVEGERTEIGDRIAGDRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICR2</accession>
    <name>K0ICR2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">lig</name>
        <name evidence="16" type="ordered locus">Ngar_c22260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22260"/>
    <dbReference type="EnsemblBacteria" id="AFU59156">
        <property type="protein sequence ID" value="AFU59156"/>
        <property type="gene ID" value="Ngar_c22260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2205"/>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_2"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="328"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFU59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="597" mass="66967" checksum="0AFD9244D668BC39" modified="2012-11-28" version="1">MDFAPIVETFEQMEQTSSRLALTEYLVALLRKTPPDIIDKVTYLIQGKLYPDYEGIELGVAERMVIRAIASSSGKDQLQIEKLYQKTGDLGDAAGEAMKSKSQSTLFSEPMTVERVYSTFDRVARTTGPGSQETKLRLISSLLNDATAAEGRYIIKFVMGQLRLGIADYTVLDALAVAFTGDKANRQVLENAYNVSSDLGTVARLLATKGLDAVKSIKITLFKPIRPMLAERIRTAEEALERMEGKAAVEYKLDGERVQLHKGKQNVELFSRRLEKITSHYPDVAEAIKSIKSEVILEGEVVAINAETGDYLPFQELMHRRRKYGVEEAMENYPVVMNFFDVLYVDGKSKTELTYMERRKLLKKIIDAVKDDNKVRLIEQTIATKPEEIDRFMAAAIEDGCEGVMIKQLSSTYRAGAREYAWVKLKREYRSDLADTLDLVVVGALHGRGRRTGKYGALLLAAYDQKTDMFQSVTKVGTGFTDVHLEQFYNELEKHIINQRHARVQTGMDMDVWFEPNMVIEVIASEITLSPSHAAALNALRPGYGLALRFPKFTGKIRDDKKPEDATATEEIVEMYRRQLKVAGPSYAAEAEGEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDE0</accession>
    <name>K0IDE0_NITGG</name>
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        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59411">
        <property type="protein sequence ID" value="AFU59411"/>
        <property type="gene ID" value="Ngar_c24890"/>
    </dbReference>
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    <dbReference type="BioCyc" id="CNIT1237085:G1324-2487-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11637" checksum="AB61DE2602DD721C" modified="2012-11-28" version="1">MVHEYRDRVYIRKDVILKLSEYGELNQSKLMSYCGLNNVKHKAIIDDMVEKGLIIRFEEPWGNKTIIKYKVSEKGRAIFQEILEPYEVLFPRSEGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDH4</accession>
    <name>K0IDH4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
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            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57695">
        <property type="protein sequence ID" value="AFU57695"/>
        <property type="gene ID" value="Ngar_c07520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07520"/>
    <dbReference type="HOGENOM" id="CLU_2949419_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-750-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6966" checksum="64B404872E46200B" modified="2012-11-28" version="1">MKGKSAMDSGRSVAHSIYGFFTDFVEMKRHFRYHSYMHLGCSRQRCRYCQQEYKASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDJ9</accession>
    <name>K0IDJ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57745">
        <property type="protein sequence ID" value="AFU57745"/>
        <property type="gene ID" value="Ngar_c08030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08030"/>
    <dbReference type="HOGENOM" id="CLU_3021089_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-801-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6243" checksum="14A5190284805AB6" modified="2012-11-28" version="1">MDRATDKWQELFSRYGEWIRNYCVEAAAVVAPTRDINGGEDLATATTVVTRIHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE71</accession>
    <name>K0IE71_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutathione reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59656">
        <property type="protein sequence ID" value="AFU59656"/>
        <property type="gene ID" value="Ngar_c27350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27350"/>
    <dbReference type="HOGENOM" id="CLU_2204194_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2735-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="11875" checksum="239B441D2FBB286C" modified="2012-11-28" version="1">MKDKVKKIESSGKNKMDLGNGLSIEYPLTVHHETFNGTVQKAEVDLVLYMTKRIPNIDGLNLDTVGVEYDKICIKVNEYLQTTVPNIYAGGDITNTTKKLTTVGNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEF2</accession>
    <name>K0IEF2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58150">
        <property type="protein sequence ID" value="AFU58150"/>
        <property type="gene ID" value="Ngar_c12100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12100"/>
    <dbReference type="HOGENOM" id="CLU_1599071_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1208-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="166" mass="18888" checksum="92364855B3AB6FE7" modified="2012-11-28" version="1">MFVSAALQKLLGFWRRYENLNLKVAFVLILLQLIHLYWLTADVVVKMITGNSALGLQISSPLLLFFVVIDYIEIPALAAGVTYYALSIYKHQKGSDKNALLLAMLSVQVFHIFWITDEVVYETFFGSASAVEIPYYVAWIAILIDYLELPVIADLFYRTIVKGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM6</accession>
    <name>K0IEM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57228">
        <property type="protein sequence ID" value="AFU57228"/>
        <property type="gene ID" value="Ngar_c02800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02800"/>
    <dbReference type="HOGENOM" id="CLU_1472029_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-280-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="18621" checksum="78A3099BD4D28381" modified="2012-11-28" version="1">MIRPFLFIALVAAAATTQAGLAYGHFFGDTKNVDRYQVVFAPNPSNPTAGDNSTLNFSVLENNANIYNIYAAVMITDQSGRVVDQVPYKLYEFSDITIPYSFRENGRYTVTLQTRIIGDEKYQSSPLEASFDITVGLIPFDELMLFYVTPAAVAIAGIAIYLHSKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEQ7</accession>
    <name>K0IEQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58240">
        <property type="protein sequence ID" value="AFU58240"/>
        <property type="gene ID" value="Ngar_c13020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13020"/>
    <dbReference type="HOGENOM" id="CLU_2476119_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1300-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9335" checksum="F30949F9EAE04B09" modified="2012-11-28" version="1">MLVVKRCAYHGITPGLAGQDNSPDSNMGNKMSYNSIMGTTGPINTIGISIEVLQAAFIGLMASIIAYKAEMGRFDKKTLLQFGMGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF08</accession>
    <name>K0IF08_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="1">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nnrE</name>
        <name evidence="3" type="ordered locus">Ngar_c14240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14240"/>
    <dbReference type="EnsemblBacteria" id="AFU58360">
        <property type="protein sequence ID" value="AFU58360"/>
        <property type="gene ID" value="Ngar_c14240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14240"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1390"/>
    <dbReference type="HOGENOM" id="CLU_024853_0_1_2"/>
    <dbReference type="OMA" id="IKAANHI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="PTHR13232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="136"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24350" checksum="1E5F827B6B2CED27" modified="2012-11-28" version="1">MKKPITSDQMYRIEENGHSVLGMRRFLMMENAGHGVADFIVHKFKRLKNKRIVAVCGTGNNGGDGFVASRHLAGHGTKITVILLGSPSDLRSEEARLNWGIIEKMNSIEIIFGKELTDEIKSRIAKANIILDSIFGTGIKGGIREPYASAIDAINKSKAYVLAVDVPSGFDPNTGQIHEKCVRADATITFHRLKTGLTKGKKYTGPVHVEWIGIPPEAESGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF22</accession>
    <name>K0IF22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14390"/>
    <dbReference type="EnsemblBacteria" id="AFU58375">
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        <property type="gene ID" value="Ngar_c14390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14390"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1404"/>
    <dbReference type="HOGENOM" id="CLU_2257318_0_0_2"/>
    <dbReference type="OMA" id="IVVPIER"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1437-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11693" checksum="E6630E77832519BB" modified="2012-11-28" version="1">MSSNDPIDPVEAFRKAIEKGSEAQKDFIKQFSNIQQDVMQNYFTVLRGLTFYNAMFKTTVQSGGRISIPEAERQALNIEEGDLVQVIVVPIERKRKGAQQKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF64</accession>
    <name>K0IF64_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58430">
        <property type="protein sequence ID" value="AFU58430"/>
        <property type="gene ID" value="Ngar_c14950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14950"/>
    <dbReference type="HOGENOM" id="CLU_2712966_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1493-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="7893" checksum="378C9B1A549B0DE6" modified="2012-11-28" version="1">MYGEFPKILSIAICVLLLVVTAIIGLPRANTNVTVESRPAAIIPSSASLKDPNLELQLVFKVSHGFRIFRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF70</accession>
    <name>K0IF70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57463">
        <property type="protein sequence ID" value="AFU57463"/>
        <property type="gene ID" value="Ngar_c05200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05200"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-518-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="23666" checksum="0D967DD1ED11E591" modified="2012-11-28" version="1">MSAATTRYFNKGVMTLDAPHIGWVVRETNDKIVVFGEGDDRFDIPKDKIRFASRNVLIDLPFYEIVRQYKVSRDEPLPTDVAPISPWPKEWPPDVDLATYEGRYPNSLFNKGVRTQDEEHVGHVMKETDDMIVIWGHYDWRFDVPKSRIIAVGRNVILGMNYPEVFQYRVDRNAPLPTGESVEKLGDEQGEIGKQRQPGAASTSEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF86</accession>
    <name>K0IF86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58460">
        <property type="protein sequence ID" value="AFU58460"/>
        <property type="gene ID" value="Ngar_c15260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15260"/>
    <dbReference type="HOGENOM" id="CLU_138336_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1524-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="162" mass="18221" checksum="9DF015F7CC2953F6" modified="2012-11-28" version="1">MEISWDGPDPKDRVACPYPVDFASKPAPAETLNSLESGRLFLQVYLGDGVRQVSAKLINNAKKENLEKMQSSSTLMRKTFLTALLTQDNRRPCMWTGELNIPSSWMEGGTRTYERTGAASPKSKRNLYTLEITYVLEGGNSCTAYFNSEDAFHWQARAEPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA2</accession>
    <name>K0IFA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57503">
        <property type="protein sequence ID" value="AFU57503"/>
        <property type="gene ID" value="Ngar_c05600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05600"/>
    <dbReference type="HOGENOM" id="CLU_097039_2_0_2"/>
    <dbReference type="OMA" id="LEMNRDW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-558-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="20056" checksum="01847F3BF7A7D377" modified="2012-11-28" version="1">MRTTTIVVIVAAAAAGIIAGAVLLVTPVARSAEQADSPQEIIIGGEKTPDNSTDDGYRQVNVTVNGVNLVADVAETNEQRSKGLTVKDTLGENESMLFVFETSQKYPFWMPPEMKFPIDIMWLDSNKTVVYIEESAQPCEIYPPISCPNYVPDEDAQYVLETVAGFARKYNVIEGTQVKFDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFE9</accession>
    <name>K0IFE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <ecNumber evidence="9">2.5.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">menA</name>
        <name evidence="9" type="ordered locus">Ngar_c16070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16070"/>
    <dbReference type="EnsemblBacteria" id="AFU58540">
        <property type="protein sequence ID" value="AFU58540"/>
        <property type="gene ID" value="Ngar_c16070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16070"/>
    <dbReference type="HOGENOM" id="CLU_043611_0_1_2"/>
    <dbReference type="OMA" id="KIWVAST"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="292" mass="31214" checksum="056BCC01AFF6CA5A" modified="2012-11-28" version="1">MLSSWLRAIRIRFLLASVIAVSNGLAIAYWKTGTIDPLYAALTYVGVLFLHTSVDLLNDYWDHKRGIDSATTRTKFSGGTGVLPENLLTPRAVYAAGVIFLILGASIGAYFVAVRGVTIAVILGFAVVAIYFYSTSIVNAGLGELFVAIKGAMIVLGTFFVQLAAIEPAALYVGAIVGILSATVLFVNSFPDFEADRSKGRRTLVGVLGKKAAARAFPLFIFAAYAMIVAGILLGFTKIYSLISLVSIPFAAKSIMSLRKDQQSIDKLMPAMASAVTYSRITGFLLALSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFH2</accession>
    <name>K0IFH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58560">
        <property type="protein sequence ID" value="AFU58560"/>
        <property type="gene ID" value="Ngar_c16270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16270"/>
    <dbReference type="HOGENOM" id="CLU_2366305_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1625-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="9944" checksum="6E499BF4EFEDDC57" modified="2012-11-28" version="1">MMTAISLGIIMFAYMIPVFVIPVALGVSEITNCTDYGCTSSAFTKCGGFSSSSSEDSSSSFDSWTRGMKGMLCLIGLDMGTSANAFAGQIILNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFT6</accession>
    <name>K0IFT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60256">
        <property type="protein sequence ID" value="AFU60256"/>
        <property type="gene ID" value="Ngar_c33410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33410"/>
    <dbReference type="HOGENOM" id="CLU_3338600_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3341-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4164" checksum="69DBC2D623C567BD" modified="2012-11-28" version="1">MATATAATWKTCLLFCHTKSLLQSKIVTKEHLDELMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFV5</accession>
    <name>K0IFV5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC efflux transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c33610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33610"/>
    <dbReference type="EnsemblBacteria" id="AFU60276">
        <property type="protein sequence ID" value="AFU60276"/>
        <property type="gene ID" value="Ngar_c33610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3350"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3361-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="45"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="286" mass="31307" checksum="2BCC367126BAE3CD" modified="2012-11-28" version="1">MKEEHHHPTGRGNSMLNDPPAGKESHAPSSSRLHPTTATTTTVALRLENVKKVFDSRSASAKKVVALDGISFEIKKGEFVSIVGPSGSGKSTLLNIIGALDRPTAGKVFINGQDIFLLDDTRLSDIRNRLIGFIFQSYNLVNRMSVQENVEFPAVFSPARPSSFSFDKSARALELLEILGIKDKAKQKPVDLSGGEQQRVAIARALINDPALVLADEPTGNLDTKTGREVFDLLRMLSDRFGTTVVMVTHNLELAGMTDKSIYIRDGRVEKEEKCRAPPRQEPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFX8</accession>
    <name>K0IFX8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="16">BCAT</shortName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ilvE2</name>
        <name evidence="16" type="synonym">ilvE</name>
        <name evidence="17" type="ordered locus">Ngar_c33860</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 16">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 16">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33860"/>
    <dbReference type="EnsemblBacteria" id="AFU60301">
        <property type="protein sequence ID" value="AFU60301"/>
        <property type="gene ID" value="Ngar_c33860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33860"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3379"/>
    <dbReference type="HOGENOM" id="CLU_020844_3_1_2"/>
    <dbReference type="OMA" id="WRGSEMM"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFU60301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="312" mass="33934" checksum="292C954F913D1680" modified="2012-11-28" version="1">MTEGKIWLNGSLVDYDNAKIHILTHALHYATGVFEGIRCYKTVNGNSAMFRLQDHMQRLLDSGRIYFMDLGYTRQQLEKAAIDTVKANRMEECYIRPIAYYGYGKMGVNPMPNKVSVAIAVWKWDEYLKGGEGGGGGSDGKGARLMVSSWTRIDPKSLPMGAKATANYANSALARVEAIKAGFDEAVMLNSAGMVVEASAENIFIVKDGALATPPTTSGALAGITRDSIMAIAKENGIECKVRDISRDELYTASEVFLTGTAAEVKPVGEIDNRMIGDGRAGKMTKQLKSLFEAAVHGKDKKFSKAWLTPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG32</accession>
    <name>K0IG32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57768">
        <property type="protein sequence ID" value="AFU57768"/>
        <property type="gene ID" value="Ngar_c08260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08260"/>
    <dbReference type="HOGENOM" id="CLU_2949420_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-824-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6528" checksum="495F7A5D28AC9578" modified="2012-11-28" version="1">MELAEQVFKSILVDELAVFVDDLNVAIEQTTDSTTSSFIFVVPVEKRPETLELVGTCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG74</accession>
    <name>K0IG74_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34880"/>
    <dbReference type="EnsemblBacteria" id="AFU60401">
        <property type="protein sequence ID" value="AFU60401"/>
        <property type="gene ID" value="Ngar_c34880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34880"/>
    <dbReference type="HOGENOM" id="CLU_121770_0_0_2"/>
    <dbReference type="OMA" id="HEDIFEH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3489-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="20163" checksum="48CE0FF8B38879EB" modified="2012-11-28" version="1">MELQFDSLSPEEAAVSKAKVIITTRDEAGIVNRKGVVMMLDTELEKYPAIAKAKILRSIIGDQAADDQLVIGIDPGSRIGISAMYLHQEIASTVESSPQDAIDQVSAMLGGIESHKKVVKIGDGNITMARNIARMLKMKFRDHVNIEIVDEHGTSQNADANKRGARDRSSARTIAFRSGKSFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGJ1</accession>
    <name>K0IGJ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35880"/>
    <dbReference type="EnsemblBacteria" id="AFU60501">
        <property type="protein sequence ID" value="AFU60501"/>
        <property type="gene ID" value="Ngar_c35880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35880"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3589-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8575" checksum="F445204DCEA1FDCB" modified="2012-11-28" version="1">MTKAFVLINTDSGLEKLVHEEIKSLNGVKAVYDLYGEYDLMVVIEQDTDKDVAEVVSWELRKVKGIRSTNTMVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR7</accession>
    <name>K0IGR7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative succinate dehydrogenase/fumarate reductase</fullName>
            <ecNumber evidence="8">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhD</name>
        <name evidence="8" type="ordered locus">Ngar_c20990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.1" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20990"/>
    <dbReference type="EnsemblBacteria" id="AFU59030">
        <property type="protein sequence ID" value="AFU59030"/>
        <property type="gene ID" value="Ngar_c20990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20990"/>
    <dbReference type="HOGENOM" id="CLU_2067882_0_0_2"/>
    <dbReference type="OMA" id="TIMKIHY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="13282" checksum="F21BC2320208C448" modified="2012-11-28" version="1">MSMLRESQIMKIHYITGIAALFVVAVHIMMRLIMPYNMSLEYENVIANYHNLPYAILLESILVLIAIHGFNGLRIILLELRQSKSWEDGVTILTIAAMMAVIAYGTRTIIVANGLGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR8</accession>
    <name>K0IGR8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gdhA</name>
        <name evidence="10" type="ordered locus">Ngar_c10960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10960"/>
    <dbReference type="EnsemblBacteria" id="AFU58038">
        <property type="protein sequence ID" value="AFU58038"/>
        <property type="gene ID" value="Ngar_c10960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1038"/>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_2"/>
    <dbReference type="OMA" id="WLQNRNG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="191"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="424" mass="46006" checksum="4B96B3A16B3B7CC2" modified="2012-11-28" version="1">MLDTAKSSAGSINPFEVALKQLDEAAKLIKLDKGLHQVLANPKRVLTVSLPVKMDNGEIRVFTGFRSQHNDARGPYKGGIRYHPQVTVDEVKALSMWMTWKCAVADIPYGGGKGGIICNPKEMSTSELERLTRRYAYAIADIIGPHTDIPAPDVYTGGKEMAWIMDTYSALKGNYVQPEVITGKPIAIGGSLGRNEATGRGLAFTVREAAKKLKINMKSATVAVQGFGNAGQFASQLVEEQGATVIAASDSKGGVYNKAGMKVEALRKHKEKTGSVVGFPGAKSISNEELLETDCTILIPAALENQITAKNAGKIKAKLVAEAANGPTTPEADDILYKNKVLTIPDILANGGGVTVSYFEWLQNLRREYWSEAEVNERLDRNITKSFLDTYTTSEKYGVNMRKASTVLAVNRVVEAIQLRGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH02</accession>
    <name>K0IH02_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Ngar_c01470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01470"/>
    <dbReference type="EnsemblBacteria" id="AFU57097">
        <property type="protein sequence ID" value="AFU57097"/>
        <property type="gene ID" value="Ngar_c01470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01470"/>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_2"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-147-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="PTHR12209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="23214" checksum="E116DB4BE44908DE" modified="2012-11-28" version="1">MQQPRLVKKGAEADIYLVEWGGKKAVSKVRTPKPYRHRELDAAIRKHRTIHEANFMSAAKAAGVMTPFVHFVDPVNAEIIMQFVEGENVRDSITPSLCYEMGRYAAMLHASNIIHGDLTTSNFITSKKQQLVLLDFGLSYYSERKEDIATDIRLIKEVFTSAHIAVKKAFPSFVGGYASVAGKNRTDKILENVKEIEQRGRYARVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH90</accession>
    <name>K0IH90_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58228">
        <property type="protein sequence ID" value="AFU58228"/>
        <property type="gene ID" value="Ngar_c12880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12880"/>
    <dbReference type="HOGENOM" id="CLU_2565856_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1286-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9777" checksum="1646A8F36AE69731" modified="2012-11-28" version="1">MLFKKIRIVQRRLQDVQRPLFDAKLGLRVDYSGFWRIRTTTETKAVEAGPHSVKWRWFYNFLNNEDHMPAKAIRPMTTKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHD2</accession>
    <name>K0IHD2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59340">
        <property type="protein sequence ID" value="AFU59340"/>
        <property type="gene ID" value="Ngar_c24150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24150"/>
    <dbReference type="HOGENOM" id="CLU_2216928_0_0_2"/>
    <dbReference type="OMA" id="DAFCKES"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2413-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="13307" checksum="87136A676ABC809A" modified="2012-11-28" version="1">MEEQQPVVRRKGKHASSTENRRMVWENVVWPLVLEVNRSYFTLKEYHVKRDAFCKESGVAPSKVAGGFVSLLIKNIITRDKNIYSIHYRLIPYMRKKAPLEYGLVIREVNTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHG3</accession>
    <name>K0IHG3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Blue copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02890"/>
    <dbReference type="EnsemblBacteria" id="AFU57237">
        <property type="protein sequence ID" value="AFU57237"/>
        <property type="gene ID" value="Ngar_c02890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02890"/>
    <dbReference type="HOGENOM" id="CLU_083799_0_0_2"/>
    <dbReference type="OMA" id="MIRDITM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-289-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="47"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="274" mass="27772" checksum="627CBDAD7FC62CCB" modified="2012-11-28" version="1">MDSKIAVAVGLAAVLAAVLAPISTLAPAFAAEIAADVTTASSSKTTDAYSPNPLNINVGDTVTWTNRDSTAHTVTSGTGVNDPNKGKAFDSSPNFNPLLVPQGTFSHTFTEAGEFPYFCALHPNMVGTVVVSAGGGNGGNGGTTTPFSVTATADGTEYPITGTGAATATAATINPGQSVEIEFEGSGAVELTLPKNMIRDITMVNGEPATIVSQNDTSTTISFEVPEGESTVTIQAGFVVPEFPVIAAILAATIAGITGYTRFARNGTAFFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ0</accession>
    <name>K0IHJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59405">
        <property type="protein sequence ID" value="AFU59405"/>
        <property type="gene ID" value="Ngar_c24830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24830"/>
    <dbReference type="HOGENOM" id="CLU_2433703_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2481-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046257">
        <property type="entry name" value="DUF6290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19807">
        <property type="entry name" value="DUF6290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10377" checksum="F2C3936FCFAD84D8" modified="2012-11-28" version="1">MPTITAELSQKELEAIREYANLCGETISDLIRKALIREATLADGYGADDPAYEYQMMAVPDNGSMKSKEHKIIQENYNKIRRILGWQEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHK6</accession>
    <name>K0IHK6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Rieske [2Fe-2S] domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c14520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14520"/>
    <dbReference type="EnsemblBacteria" id="AFU58388">
        <property type="protein sequence ID" value="AFU58388"/>
        <property type="gene ID" value="Ngar_c14520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1416"/>
    <dbReference type="HOGENOM" id="CLU_1478847_0_0_2"/>
    <dbReference type="OMA" id="RGECPCH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1450-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20033" checksum="3BEBFAFEDE4883FC" modified="2012-11-28" version="1">MTFAPFVDWGKFLPNPATQAAQKVKIELEDGSIANVNTFEVNSSQVVIYPKTDDEVLNQEAFRTWQLIRLPAELGGNRNDASAFRLYSMVCLHLWCLWKYWPQEGRKRGECPCHGSMYDPYTGKAFAGPAALQGPPSNVLPRLDIEVESNGDLSILPPVWSPDRNGVVGFGRYLNNNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR4</accession>
    <name>K0IHR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58488">
        <property type="protein sequence ID" value="AFU58488"/>
        <property type="gene ID" value="Ngar_c15540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15540"/>
    <dbReference type="HOGENOM" id="CLU_2243944_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1552-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11286" checksum="20F493135ABFB10B" modified="2012-11-28" version="1">MQTEIASAILARLASVSSEGPSAVSMSQIKMWIVPQESEHDHDYNINDSYFEVLLSRTIGDLLAKGYIACSVRDGVEDGDGQMFSLTAKGARYVEELAAASLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY2</accession>
    <name>K0IHY2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase of the beta-lactamase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05840"/>
    <dbReference type="EnsemblBacteria" id="AFU57527">
        <property type="protein sequence ID" value="AFU57527"/>
        <property type="gene ID" value="Ngar_c05840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05840"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.559"/>
    <dbReference type="HOGENOM" id="CLU_070010_0_1_2"/>
    <dbReference type="OMA" id="CMNLPYT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-582-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="219" mass="23973" checksum="87C0294B3D44F4E3" modified="2012-11-28" version="1">MLDFNGVSFHWLGHDGFKIIAGGKTIYTDPYQLSRAQHSKNDADIVFISHNHFDHLSMDDLKHVIGKKTTVVAAKECIEQLKAAGAAEIKGVAPGDRLTVQDLPVEVIAAYNTNKKFHPKEDGKVGFVFTVGGNMRIYHTGDTDDIPEMSATKPDVALVPVSGTYVMTAEEAARAVNEKIKPKKLAIPMHYGSIVGSDQDATKFKQLVTACPVRILNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II13</accession>
    <name>K0II13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57607">
        <property type="protein sequence ID" value="AFU57607"/>
        <property type="gene ID" value="Ngar_c06640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06640"/>
    <dbReference type="HOGENOM" id="CLU_1192654_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-662-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="234" mass="25930" checksum="241F4A639DA5CA58" modified="2012-11-28" version="1">MPQAIRSLWFEEISFIHEKFFDTPIGKLTVRQVAIVFVFGVSAWAAFNSVGDDDMLKVAVTSLLVILALAFAFQRIKTLTPEQSMMFALFAPKTSTGRSRRIKKNTNTPISTLSVDVGQQKGSETFDISVLDASDNIQDGQIQKLVVLVRDPQTGHPLPNRGCGILVDSERIGRRLTDEEGFLTIPFVPKQGINTIEVKPEGYAAIVKNVTVDVHMRQQGEQLRSSKTAQVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II64</accession>
    <name>K0II64_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58643">
        <property type="protein sequence ID" value="AFU58643"/>
        <property type="gene ID" value="Ngar_c17100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17100"/>
    <dbReference type="HOGENOM" id="CLU_1381442_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1708-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="22690" checksum="CF0865B61318BA72" modified="2012-11-28" version="1">MVLASSDDHRLDNQIIQGRHRVVLISKIIEDGHKFDISKILIRREPVDSIDQLRALRAAYETTASLTKDPRMSKKWIESNLKPIIKNRVQEGQTKILSYLHDCGFYNDSIAAELIERELEQLEKKRVKKTKQQPQSRIPEHIKNQSWNGPAPRTVDNATSYIRELKFNCDHCGKENKRKVHIVCSHGGDLMSLEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0II93</accession>
    <name>K0II93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59665">
        <property type="protein sequence ID" value="AFU59665"/>
        <property type="gene ID" value="Ngar_c27440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27440"/>
    <dbReference type="HOGENOM" id="CLU_1575000_0_0_2"/>
    <dbReference type="OMA" id="SKECDIE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2744-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17187" checksum="4172209C85E29F3B" modified="2012-11-28" version="1">MSGIRLLSALKYKPAIAALTATGIFFLLPLIQLTNTLLAFDIWFLDLLQKPWSSILYITFSIFFGMFISLYMFTRNKCFDCKPEAARTGFAGSAVGFMVGVCPACFSFIGILLPLGQALFLTAYSPIFTAMSIAIVLFSIYKLGGFRKAELMMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA3</accession>
    <name>K0IIA3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57732">
        <property type="protein sequence ID" value="AFU57732"/>
        <property type="gene ID" value="Ngar_c07900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07900"/>
    <dbReference type="HOGENOM" id="CLU_2930307_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-788-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6840" checksum="32E8D8231EA17F8D" modified="2012-11-28" version="1">MLWEASVSKGKFGVVPVMETHNFNNIGSDTARVIGFFSNPNVVRTFEKVFMSANFRVQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG8</accession>
    <name>K0IIG8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27790"/>
    <dbReference type="EnsemblBacteria" id="AFU59700">
        <property type="protein sequence ID" value="AFU59700"/>
        <property type="gene ID" value="Ngar_c27790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27790"/>
    <dbReference type="HOGENOM" id="CLU_1154378_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2779-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51" evidence="1">
        <location>
            <begin position="59"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="240" mass="27712" checksum="634BBD0A8B20F20F" modified="2012-11-28" version="1">MKIRRKKSDKAKLPKLQTAYDLTAKLTFDIQDIDNSMALSTEDRACIIGSRRYANLLVTRLWVRALMSQRYGGLASKSVLCIDAGNSTNLYQCVNFARQYGMDIRTVLRRIIISRAFTIYQLAGLVIRKLPEVIHQFSTKIVVISDLLNMFLDDPQIRYREAQYLLNQIMNALWKLPRDILVIVSMYNSASKYDKLILPNFSKQIELSESDPLQIRLLQNKRTLSEFTMPENALRIVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ7</accession>
    <name>K0IIJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58878">
        <property type="protein sequence ID" value="AFU58878"/>
        <property type="gene ID" value="Ngar_c19460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19460"/>
    <dbReference type="HOGENOM" id="CLU_2044484_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1944-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="14270" checksum="91AE311D329CC628" modified="2012-11-28" version="1">MIKEEKVLAEQIKDMQKQVEWLSAQYAGSIQIRFIRCGSPNCYCAKAKKGHGPYYYLERRVSASKVEMIYLGKQKTDVNHYKNYHYRVSNLKKRLRAMKRRHQQLLGAIMSITQLVKTDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK2</accession>
    <name>K0IIK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional modulator of MazE/toxin, MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09650"/>
    <dbReference type="EnsemblBacteria" id="AFU57907">
        <property type="protein sequence ID" value="AFU57907"/>
        <property type="gene ID" value="Ngar_c09650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09650"/>
    <dbReference type="HOGENOM" id="CLU_121823_6_0_2"/>
    <dbReference type="OMA" id="DIYAIQL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-963-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13488" checksum="EA00A419CA31933B" modified="2012-11-28" version="1">MSSSSSSSYSASQRDIVLVPYPFSDLSQAKYRPAIVISNNTYNRKFKDFIAIPLTSNPNTRDHTIPVTSKEMTSGSLTVASVAKVDKVFSLEQRLVVKRYGQLREDVFDKIRAELIKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX1</accession>
    <name>K0IIX1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30070"/>
    <dbReference type="EnsemblBacteria" id="AFU59925">
        <property type="protein sequence ID" value="AFU59925"/>
        <property type="gene ID" value="Ngar_c30070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30070"/>
    <dbReference type="HOGENOM" id="CLU_2968573_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3007-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6815" checksum="BB40DFC65DA6AFBB" modified="2012-11-28" version="1">MRTMMQYSFQNMNFRGDAKPYQDLLRSMAAEGLCVKSSNPQIHDHAFKQLSEREPMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX7</accession>
    <name>K0IIX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cytochrome c biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58082">
        <property type="protein sequence ID" value="AFU58082"/>
        <property type="gene ID" value="Ngar_c11410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11410"/>
    <dbReference type="HOGENOM" id="CLU_2748317_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1139-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8230" checksum="773880689BAD4BDD" modified="2012-11-28" version="1">MVWPWPKTPSSHDPVDWVLELGRFDYQRWQKGWVDLFNSHRLVHNARKIQKIVVSKEGDGAFVVVDVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY1</accession>
    <name>K0IIY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translocation protein TolB signature-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58087">
        <property type="protein sequence ID" value="AFU58087"/>
        <property type="gene ID" value="Ngar_c11460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11460"/>
    <dbReference type="HOGENOM" id="CLU_2420144_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1144-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10005" checksum="4A2AE104FB7D51B3" modified="2012-11-28" version="1">MNKTAFLQAEDEFSPANLYIMNADGQNQTRLAATGEFLFGGGPLVWSPDSTRIAFGTIRGIYVIDISNGSFRDLTGNDHDGNLFGFQIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ69</accession>
    <name>K0IJ69_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HlyC/CorC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Ngar_c31340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31340"/>
    <dbReference type="EnsemblBacteria" id="AFU60050">
        <property type="protein sequence ID" value="AFU60050"/>
        <property type="gene ID" value="Ngar_c31340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31340"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_2"/>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3134-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="206"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="268"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="426" mass="47343" checksum="C572FC631DCECF9D" modified="2012-11-28" version="1">MVVELQFAIPALGALVALSAFFSGLEVALVSLERGQLRRLVNEKRSGANSLAKLKSNPKRMLITILLGVNLANIGAAAVATDVAIGTFGSLGLGIATGIMTFILLVFGDITPKAYCYAHAEKISLTFARVILAIQYILYPLVILLELITKGMFRAVKIEEKPKRLSEAEVRAILDIGVEEKVLMKEEREMMKEVLEFHDTAVRAIMTPRNAMFVLSARLLIWDALPLINNSGFSRIPIVDENNKDNVLGIVHTRDVLKVVETKTSYMMLKDIARKPLFVSKDMPISKLLKEFQARHLQIAIVVDEFGSTEGLVTLEDVIEELVGEITDEKDIELQMLRKVDRQTVVLQGDVEIDDVNEALNVNLPKGKDYSTISGLLHEHLQRIPREGDKATIGNVIIAVEEIGKNVPLRITVRKVSEEEDEETRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJR9</accession>
    <name>K0IJR9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34100"/>
    <dbReference type="EnsemblBacteria" id="AFU60325">
        <property type="protein sequence ID" value="AFU60325"/>
        <property type="gene ID" value="Ngar_c34100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34100"/>
    <dbReference type="HOGENOM" id="CLU_999719_0_0_2"/>
    <dbReference type="OMA" id="MAMEINT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3411-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="46"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="30650" checksum="62D28F9A0E88EAE9" modified="2012-11-28" version="1">MLNEVFLDALKNRDAKVSKVKDSNFATILAEASSRWVRYEPSPEKCESAGVDSSWNKRAFQGLYLYAIDAVAVTSANKVLAAEWDQDIAGSARTEFLESKAMAMEASVAQKAAGRVDIVCVDGSLVSRLLKSAADAASEMVKKYGSSTIFVSKSSESRLQFGPMGSRAGDIYYYGHAGSGAGFSIPAEITQFRHAPLFEVYARLRDHTPIIRIEVLGSEPSKQEMTKILDMLRYHSIAGYPYCLKLAHNTCKISNEDIDRLASIFSLQHEQGARDALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJS7</accession>
    <name>K0IJS7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58527">
        <property type="protein sequence ID" value="AFU58527"/>
        <property type="gene ID" value="Ngar_c15940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1561"/>
    <dbReference type="HOGENOM" id="CLU_2010198_0_0_2"/>
    <dbReference type="OMA" id="KWESELT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1592-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="13246" checksum="345D1ABFE4687996" modified="2012-11-28" version="1">MSIDRVLERIMLVLEELERSEKISTKVGVDRDAGIIRIYGEGSDYINRASSGLEEMLELAYTTAEHHPYWAVLYHAAEISKAALEKWESELTADQISEMSWRCDEIKVALERLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJW7</accession>
    <name>K0IJW7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="5">SDH</shortName>
            <ecNumber evidence="2 5">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">aroE</name>
        <name evidence="9" type="ordered locus">Ngar_c16290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2 5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16290"/>
    <dbReference type="EnsemblBacteria" id="AFU58562">
        <property type="protein sequence ID" value="AFU58562"/>
        <property type="gene ID" value="Ngar_c16290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1601"/>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_2"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="6">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="8">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="5">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="281" mass="30371" checksum="546F80D3A8F7B016" modified="2012-11-28" version="1">MQGSIKTYCIIGDPIQHSLSPGMQNAAFAALGLNCTYIAFRVPANELKESIESLRSINIAGFNVTVPHKVEVMRYLDELDASAKKAAAVNTVNNIEGIFKGYNTDIDGFIEPLHRRHVDFGGMQVLLLGAGGAARAVVAALSQERGIAKVTIANRDVQKAAELAKIGSGLGLKSETLPLENAQDVSLECDLIVNATTLGLHKEPSVIDHEHIKKGSIVYDIVYRPIVTDLIENAKYAQATVVYGYEMLIEQGAKAFEIWTGLPAPREAMKKNLLGIFGEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK23</accession>
    <name>K0IK23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58642">
        <property type="protein sequence ID" value="AFU58642"/>
        <property type="gene ID" value="Ngar_c17090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17090"/>
    <dbReference type="HOGENOM" id="CLU_2067880_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1707-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="13729" checksum="21F2620F31BEF7DD" modified="2012-11-28" version="1">MRLPNCIKENYTKKQDAAGCYRALLQCRRVIKRLAAQYGNLQHMKLEHDQRKIQFSNMAFLTKIYLIFTFIVVGSVGYYAWNNKQADVVIFVFVLLYGIISTVIFSSWRKRGRAATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK49</accession>
    <name>K0IK49_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+ transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60515">
        <property type="protein sequence ID" value="AFU60515"/>
        <property type="gene ID" value="Ngar_c33751"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33751"/>
    <dbReference type="HOGENOM" id="CLU_1881148_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3376-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="14989" checksum="FEEE6732ECF8C593" modified="2012-11-28" version="1">MILSALPFAFHYYIFSRKGLFTKKTLGPEVTVYLIMVAASVPIFYLLAIGTAGLDMGAAAYHKRVDQRGLPVPQHRLHHASDQSKVFMIILMLVGGTAFSTAGGMKVGWFVILYQEFAKRIGTKKSEMQVLYIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKB3</accession>
    <name>K0IKB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tRNA-splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">endA2</name>
        <name evidence="4" type="ordered locus">Ngar_c18600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18600"/>
    <dbReference type="EnsemblBacteria" id="AFU58792">
        <property type="protein sequence ID" value="AFU58792"/>
        <property type="gene ID" value="Ngar_c18600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1843"/>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OMA" id="SSPRYMI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="3">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="2">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="203" mass="23280" checksum="F78DF1F4D7807A7E" modified="2012-11-28" version="1">MSSSATAPPSAQQPFSGSKMSEAEMPSVVEARLAAGGKILVDKTRFQDELRTKGFGEKEDAEYVLKPYEALYLMHTKRLALKNKPGMTFDPLFELLLKYDRNIMTKFLVYRDLRSRGYVAKEGFGFGNDFRVYDRGEYEKKPAKYVIFGINEGTNTTVKDFASAIDQIERMGKEAVVAVIERRGEVIYYKASKMRFTENRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC1</accession>
    <name>K0IKC1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HEAT repeat-containing PBS lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27520"/>
    <dbReference type="EnsemblBacteria" id="AFU59673">
        <property type="protein sequence ID" value="AFU59673"/>
        <property type="gene ID" value="Ngar_c27520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2728"/>
    <dbReference type="HOGENOM" id="CLU_1754610_0_0_2"/>
    <dbReference type="OMA" id="MFVRHEA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2752-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16150" checksum="4C159E61CAB62033" modified="2012-11-28" version="1">MEKQFEIKNEQYFKELLDHPDSVVRTRAVCILADIAGENAVSPIGKVLKEDKNALVRHEAAFSLGQLGFTSGITALANAVRSDPSFFVRHEAAVALGVIGSEEARKVLNDALKDESEEVRESAVVALANLDYIRNTNSNSRFTKMTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK0</accession>
    <name>K0IKK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59808">
        <property type="protein sequence ID" value="AFU59808"/>
        <property type="gene ID" value="Ngar_c28890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28890"/>
    <dbReference type="HOGENOM" id="CLU_1902002_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2889-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13398" checksum="59E9AE5FA31D5270" modified="2012-11-28" version="1">MDWKPLVLLGESDKKMDAALTGMLKRQGVAVVAANTPKELLNLLDKYKEAIDLVCINGRLASERGGLLISRARTIGRNVRVIVVADRDDDRVNILRYGADEFIQKPLSPDVVAAKIMALIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM0</accession>
    <name>K0IKM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59838">
        <property type="protein sequence ID" value="AFU59838"/>
        <property type="gene ID" value="Ngar_c29190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29190"/>
    <dbReference type="HOGENOM" id="CLU_3075483_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2919-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5841" checksum="5007F23F9258F1FC" modified="2012-11-28" version="1">MERSQFQTEIIHKCLTSSCSECTGFYVSDVLARRFICKCCCHSSLSVGMEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ1</accession>
    <name>K0IKQ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59092">
        <property type="protein sequence ID" value="AFU59092"/>
        <property type="gene ID" value="Ngar_c21620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21620"/>
    <dbReference type="HOGENOM" id="CLU_478698_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2160-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="569" mass="60945" checksum="9C1E98FC88A21FEC" modified="2012-11-28" version="1">MMAKHITAILLAALVAASGAAGLFYFAGAQEQAEITVVDNQPQPGSQIDVAGSNNLANSDVSIYSISTTATVQNQSNQTLPESNNITATTQNQTEDDDNNNQTATNGGASVRVEEAEAEPGEPLAISGDGFQPNVLVQIFINNVQITNIITNVEGSFNTLVVVPTTVTAGSAQVTVRTEQTNIFKNVNIVQPDERDKEPATVRFTSVSATDNARALRGAPVAVFDAGSDQMVDSGETPMSLELEEGTYSVFYSDFGSFDFQSAQPGRWTDTPDGGSGLITVREGRNATVTAMYSELPSPPPPPRETVNSITLRAQDTDGNVLNGMFATVYDDNGTKVKQEFTQLQVGNLPPGTYRIFYANFNDLVFVSASPGSWVQTPFGGTGVVIIPDDGKDHHVVVTATYDRMITNAHEQFNIRAPLDIGGDIFTITSNKTHPEGPFIMSGSFGLRVTDEDPLRASLSAHIVSVRGDSNENVNLPSQKSRDHDTLQIVDLDPQVARPVGANSYIVSGTADLLLNGNMYSDDERIQVMVRGGDDLTPTNIEIEFQGEHNNSAAHRLETLYGAVTSGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT0</accession>
    <name>K0IKT0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mercuric reductase, MerA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59147">
        <property type="protein sequence ID" value="AFU59147"/>
        <property type="gene ID" value="Ngar_c22170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22170"/>
    <dbReference type="HOGENOM" id="CLU_2949426_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2215-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6447" checksum="7FDB4A33BA7647F6" modified="2012-11-28" version="1">MTEVPKALTVNDTKGLIKMAVDPKKNNRIVGVHILSGIAANMIHEAVMAVKYRLTIDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKU3</accession>
    <name>K0IKU3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">csl4</name>
        <name evidence="4" type="ordered locus">Ngar_c30820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30820"/>
    <dbReference type="EnsemblBacteria" id="AFU59998">
        <property type="protein sequence ID" value="AFU59998"/>
        <property type="gene ID" value="Ngar_c30820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30820"/>
    <dbReference type="HOGENOM" id="CLU_067135_1_1_2"/>
    <dbReference type="OMA" id="CGNVETR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="PTHR12686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="200" mass="22241" checksum="7339C606E08F6740" modified="2012-11-28" version="1">MSREDNKLTLPGERVASIEEFEGGKNTYMTPDGTVRSATVGTTVYDLKRRIVKIEQKNSPMLPKVGDIIVGYVEMMFSSMVSIKVLYINDKWSEAGFSAIASARIGSRADVERRGDRRATFHNGDIVRGRVISLLNSTIHLTLTEKEYGLLYALCFICGGDTVRTSESTIKCVECGAFENRKLAHDYGKESFRLVLKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL12</accession>
    <name>K0IL12_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)</fullName>
            <ecNumber evidence="3">2.1.1.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cbiT</name>
        <name evidence="5" type="ordered locus">Ngar_c31820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36067"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:70791"/>
            <dbReference type="ChEBI" id="CHEBI:72780"/>
            <dbReference type="EC" id="2.1.1.196"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.196" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31820"/>
    <dbReference type="EnsemblBacteria" id="AFU60098">
        <property type="protein sequence ID" value="AFU60098"/>
        <property type="gene ID" value="Ngar_c31820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31820"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3167"/>
    <dbReference type="HOGENOM" id="CLU_094143_0_0_2"/>
    <dbReference type="OMA" id="RCKFVYA"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043776">
        <property type="term" value="F:cobalt-precorrin-6B C5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00786">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023475">
        <property type="entry name" value="CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="4">
        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="195" mass="21285" checksum="B3DCC0879C39A341" modified="2012-11-28" version="1">MLWDYRTPGIPDELFERTEEVPITKEDIRAIALSKLRLREGHSAIDIGCGSGSITVELCLQTKGGSVYAIDFDQKAVELTKKNLRKFGANAEVILGKAQDVLPKLPQVDAVMVGGTWGDTRQVIELAASKLKKGGRIVIDTILVETMYQALAAVNELKLAEVDITQITISKARKVTTGTMMLARNPVMMISATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL15</accession>
    <name>K0IL15_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose-phosphate pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prs</name>
        <name evidence="3" type="ordered locus">Ngar_c23310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23310"/>
    <dbReference type="EnsemblBacteria" id="AFU59257">
        <property type="protein sequence ID" value="AFU59257"/>
        <property type="gene ID" value="Ngar_c23310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23310"/>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="298" mass="32133" checksum="07391FB968F3B062" modified="2012-11-28" version="1">MSEISIITGPASSDLADKIAKKLDAQMVAAELRIFSDGESKIKMAGRADKKNCVIVQSTYPPTDTHLMQTLMLAKKCSDDGALDVCAVIPYLAYARQDRAFLEGEVVSIALVAKLLEAAGVRHVITVDIHSQLAMSHFASIQNVSSIPLLAEYASRIMKLHRLVAVSPDAGGTDRVKEFARLLKTDTIALKKSRDRTTGEVTIEEKLDLDVSGRDTILVDDMISSGESIVKAVGVLRRNGAGKVYAMCAHALLIGDAAQKIKQAGVQDIIATNSIPGEYARVDLSPAIAEAVKSRYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE2</accession>
    <name>K0ILE2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57024">
        <property type="protein sequence ID" value="AFU57024"/>
        <property type="gene ID" value="Ngar_c00740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00740"/>
    <dbReference type="HOGENOM" id="CLU_1381441_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-74-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="1">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="22521" checksum="C01B545C2598D92B" modified="2012-11-28" version="1">MHRIPVGILKGCTIIRDVDQWYACITTTTDDSVVEKSIKTDVTKSVGIDVGLINWLALSDGRIIENPLDFDAQAKKIKQLQKNHARKQKGSRNREKARIQLAKAWRQVRRCRDDFVHKTSRTIADQGYTFVIFEKVEYQKHGQEPPSSIGNNGCHLGKAAPINCLQGRKARWTGTSRQSRWYIAEMLWVWSGSKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL0</accession>
    <name>K0ILL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01950"/>
    <dbReference type="EnsemblBacteria" id="AFU57144">
        <property type="protein sequence ID" value="AFU57144"/>
        <property type="gene ID" value="Ngar_c01950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01950"/>
    <dbReference type="HOGENOM" id="CLU_101753_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-195-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="21005" checksum="A5E890D7E05D2D87" modified="2012-11-28" version="1">MSKKKRDDSYFAADRRRKKKSMMIIIPIIVGVAIAAVVGALLYQSPQAAAISGVECNRNEFNNYHVHAHLDVFVNGQERQVPNNVGILTSPSCFYWLHTHDSDGIIHVEAPQTRVFTLGQFLDIWEQTRDQQGLFDSVAGMNVTAYVNGEQFEGNYRDIQLESQKQIVLAYGQAPAEIPAYNFGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL7</accession>
    <name>K0ILL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding lysin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02110"/>
    <dbReference type="EnsemblBacteria" id="AFU57159">
        <property type="protein sequence ID" value="AFU57159"/>
        <property type="gene ID" value="Ngar_c02110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02110"/>
    <dbReference type="HOGENOM" id="CLU_975273_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-211-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="48"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="31056" checksum="80CF06EF916CFC85" modified="2012-11-28" version="1">MVNNQEKKNQYLALAAISSIWTLLLSTIVSMGGAGSLLQAAYASSSTTTYTVVSGDTLYKIGLRFGVPWQDIAQANDIQSPYLIYVGDVLVIPLNDASDDTTAIATGNPMYDQFDSYIKSSSRNYGISDQMLVKAMISQESYFDPRAVSPDSPCGVPPGWTDAQSKSFGLMQFTPACAEPQAGPPNLTTDTTSPYWSSSWFNPQYNIDRGVQALSRELSYVKSNFYGCSDEQYLLMAVATYNSGPGAVYGCGSWNERADTHINHVLSQYKTYAEMAGAPYPYAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILN3</accession>
    <name>K0ILN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57169">
        <property type="protein sequence ID" value="AFU57169"/>
        <property type="gene ID" value="Ngar_c02210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02210"/>
    <dbReference type="HOGENOM" id="CLU_075307_0_0_2"/>
    <dbReference type="OMA" id="PPRWKMA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-221-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038762">
        <property type="entry name" value="ABM_predict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057">
        <property type="entry name" value="PTHR40057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23764" checksum="AF571E96CA941D62" modified="2012-11-28" version="1">MIGLDRRHYMTALHQNGNGKNDDGPITVIVTRKAKSGRIREFEEWMDGVIHEAMKFEGHMGVNIIRPVDASSNPEYVIIFRFNTYENLAKWEKSEIRKKWIEKSKDVTEGEAKVEMQTGLEFWFTPSSSNNPPAAIQPPRHKMAIVVTGIIFVLVSILLPQIRQATIGLPFLLSTLIGVVTMVLLMTYVIMPSVTRLLRPWLSKKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR2</accession>
    <name>K0ILR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59617">
        <property type="protein sequence ID" value="AFU59617"/>
        <property type="gene ID" value="Ngar_c26960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2671"/>
    <dbReference type="HOGENOM" id="CLU_102441_0_0_2"/>
    <dbReference type="OMA" id="LKGTIHA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2696-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="241" mass="27380" checksum="435A178C2BEF0195" modified="2012-11-28" version="1">MSSSFDPLYKVHDAYKAGQILQRVYDLVIKRFPLVTEGIKRVEEASGLKYPYYYVEPSLVVSTSAVEFTQMGILFARTIPVVGDDNLLRVVVQITAPLIAYGLKGTIHAILAHEFMHYLELVSRIVKMKVISDEVSGTLFEGTYADTGRLLEERAVFRSDPTLIRHITTRFPEGFRDLKLEDKVIKMWMDKGLPTTKVPIDANVIKIPIEAMARLQVEQVVKDKIAEFESVKLRKKKTGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT8</accession>
    <name>K0ILT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division control protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cdc6</name>
        <name evidence="1" type="ordered locus">Ngar_c03910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03910"/>
    <dbReference type="EnsemblBacteria" id="AFU57339">
        <property type="protein sequence ID" value="AFU57339"/>
        <property type="gene ID" value="Ngar_c03910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03910"/>
    <dbReference type="HOGENOM" id="CLU_1329511_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="23323" checksum="54F7BAB8DE347C4D" modified="2012-11-28" version="1">MIGTKNKLFVLALDEFDVLFYDRRGKPSDFIYKLLVMEEKLREQGHLVSIVAISNNVMSDYEKDDRVRSRIGSSEIFFNAYTKKDVLQILNDRASAAFSKPVDPTVLEYCAEMSSSEHGDARRAIDLLRVAAEIASSKSEAIEKKHVDRAAEQLQKDRISLVLSTASYHFRLVAAAIAKDTYVNGEDWHSTSSLYDRYCNLVQEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX2</accession>
    <name>K0ILX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59757">
        <property type="protein sequence ID" value="AFU59757"/>
        <property type="gene ID" value="Ngar_c28370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28370"/>
    <dbReference type="HOGENOM" id="CLU_2875212_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2837-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7585" checksum="B1B0423C7FEE249C" modified="2012-11-28" version="1">MIHSYTNIHKQMKRLQITLEDDLYQWVTKEIERLRFGSYSHTINFALKQLKEAETTSKDGNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ7</accession>
    <name>K0ILZ7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c29130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29130"/>
    <dbReference type="REBASE" id="55348">
        <property type="entry name" value="M.Nga92ORF29130P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59832">
        <property type="protein sequence ID" value="AFU59832"/>
        <property type="gene ID" value="Ngar_c29130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2891"/>
    <dbReference type="HOGENOM" id="CLU_013049_4_1_2"/>
    <dbReference type="OMA" id="YEYLMGM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2913-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="152"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="512" mass="58720" checksum="503C22474998DA64" modified="2012-11-28" version="1">MKTTNGNSGDLGFEQKLWLAADKLRSNMDAAEYKHVVLGLIFLKYISDAFNEVYEEVKKDKTSDPEDIDEYLARRAFWVPKEARWDYLQKNAKKPEIGKLIDEAMDLIERDNRSLKGVLLKNYSRPGLNKQRLGELIDLIGTIGLGDKENRSKDVLGRVYEYFLGQFADAEGKKGGQFYTPRSIVKLLVEMLEPFKGRIFDPCCGSGGMFVQSEKFIEAHGGRIGDISIYGQESNQTTWRLCKMNLAIRGIDATKIEWGDSFRDDQFKDLRADFILANPPFNDSDWGGEHLQEDARWKFGVPPKNNANFAWVQHFIHHLSPAGVAGFVLANGSMSSNTSGEGEIRKNIIEADLVDCMVALPSQLFYNTMIPACLWFLSRNKGNHKFRARNGQILFIDARMMGVMIDRRHRELTDEDIKKISDTYHAWRGELKDKKYEDIPGFCKSATLEEVRKQQWILTPGRYVGAEEEEEDDEEFEEKMNRLTSELAKQMEEGRRLDEEIKKNLASIGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM39</accession>
    <name>K0IM39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59972">
        <property type="protein sequence ID" value="AFU59972"/>
        <property type="gene ID" value="Ngar_c30560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30560"/>
    <dbReference type="HOGENOM" id="CLU_2433700_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3056-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9617" checksum="B7379C1D4574ACD9" modified="2012-11-28" version="1">MKGEQKLKSISVLVPLERVQASLSEIGFLLDDTVTIVADGKFWNKMLYVKGDETISVSEEIGDAYPKDPIITICGSKMTISQVVKGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM55</accession>
    <name>K0IM55_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57574">
        <property type="protein sequence ID" value="AFU57574"/>
        <property type="gene ID" value="Ngar_c06310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06310"/>
    <dbReference type="HOGENOM" id="CLU_3094225_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-629-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5775" checksum="04A9D8058CCD919A" modified="2012-11-28" version="1">MSKESFAEYRCRSCGQQFSSLGDMQKHILIEHFQTGDIPAKEDAQREAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM84</accession>
    <name>K0IM84_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalt transporter family protein, subunit CbtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbtB1</name>
        <name evidence="2" type="ordered locus">Ngar_c07010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57644">
        <property type="protein sequence ID" value="AFU57644"/>
        <property type="gene ID" value="Ngar_c07010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07010"/>
    <dbReference type="HOGENOM" id="CLU_2313872_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11233" checksum="5D7AC4792E2836AA" modified="2012-11-28" version="1">MRIGHAFRLDKPSKLLNMTRSALLQMSADIKRNVSQTTTGRKPKITVGILLGVMVFGLFIVGFDQGHLFSIAQGEQAYEDLWMHEFYHDMRHAAGFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM92</accession>
    <name>K0IM92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57664">
        <property type="protein sequence ID" value="AFU57664"/>
        <property type="gene ID" value="Ngar_c07210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07210"/>
    <dbReference type="HOGENOM" id="CLU_2597860_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-719-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8423" checksum="7B9BE59BAE71367A" modified="2012-11-28" version="1">MQQTGQVQEILELARQKVEIATNPSAFGNGVPIFDNFTEALSAVGMATAIAAAATAVGGYFLYLWTKNRRAMLKTVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA6</accession>
    <name>K0IMA6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c07560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07560"/>
    <dbReference type="EnsemblBacteria" id="AFU57699">
        <property type="protein sequence ID" value="AFU57699"/>
        <property type="gene ID" value="Ngar_c07560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.729"/>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="NSVWVSH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-754-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19786" checksum="613BE966C68E23A4" modified="2012-11-28" version="1">MSTTGLFVGRFQPFHKGHLATVKFALGKVDLLVIVVGSAQKSHEPRNPFTAGERIRMVKESLDSEKEVDADRILIIPVPDVDVHSLWTRHVDMLVPKYDVVFANDPFTLMLFRERGIKTIEAPLVDRSEMRATEIRNRMITGSKWEGLVPAPVARIIKEINGVERVKAIAERSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB6</accession>
    <name>K0IMB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DUF72 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57734">
        <property type="protein sequence ID" value="AFU57734"/>
        <property type="gene ID" value="Ngar_c07920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07920"/>
    <dbReference type="HOGENOM" id="CLU_2313873_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-790-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11405" checksum="869315FF33DD4602" modified="2012-11-28" version="1">MTKGTFYGMVKATPDSFEFSIKVPETVTYMKRLDARKHATVSFNEFLDKISPLKDANKLGAILIQLPPSFSVDEFWQVEGFLERLPIGYEYALEFRYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB8</accession>
    <name>K0IMB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60162">
        <property type="protein sequence ID" value="AFU60162"/>
        <property type="gene ID" value="Ngar_c32460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32460"/>
    <dbReference type="HOGENOM" id="CLU_1212632_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3246-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="228" mass="25834" checksum="C794ACADD30BCE89" modified="2012-11-28" version="1">MKRGKRHYRLISVIPVLQPYMASVSSPLNCSVTFSNNRYLLGRFSKIAQLHGHPWLENPILSIALIAVGFVLLFISLYMMKREPKHGYNLERKIAGHKILDTSNRWMVFSAFIGLVAIGAHYLAEYALHIYDITPVDRITHGISGMAVAAAILNANLTRGRRVYYPTAIGVSWAAFIIWEVYELLSVMFDPNTNIETGPWDLGIDLWIDTLGALAICFIYDEFNEQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF5</accession>
    <name>K0IMF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60227">
        <property type="protein sequence ID" value="AFU60227"/>
        <property type="gene ID" value="Ngar_c33120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33120"/>
    <dbReference type="HOGENOM" id="CLU_094092_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3312-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="209" mass="23764" checksum="D47323B2D2EC4228" modified="2012-11-28" version="1">MGLAVEDFIENGILTIIDADSFYSPLQTKLDYKILLTQWQKIVSSVSKNGKFKRVILMGMPHQAFFESKENQKKLVEYEEEAAKCHDGSFQVFCCYTKELIDKLPLSHLIRLVIAHQNIVSSNSNNDNQEAIVSRIVDIVEEGLTKALGSETSILVLKTLRLIYKIDKGDIKSNPELFEEKLKRIIGEEVAGLVLKIIADRIKDEIVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI5</accession>
    <name>K0IMI5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA double-strand break repair rad50 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rad50</name>
        <name evidence="4" type="ordered locus">Ngar_c34020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34020"/>
    <dbReference type="EnsemblBacteria" id="AFU60317">
        <property type="protein sequence ID" value="AFU60317"/>
        <property type="gene ID" value="Ngar_c34020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34020"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3400"/>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_2"/>
    <dbReference type="OMA" id="MMIRIEN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SMC_N" evidence="2">
        <location>
            <begin position="416"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="698" mass="78199" checksum="D26C7871FE76BFD1" modified="2012-11-28" version="1">MIKDMQLKDFIAHRDTKIEFGKGITIFVGHNGSGKSSVIDAVTFALFGKHTRKSNKNLVRRGATSAMVQMRFALNSREFQATRALSGSGQQSFSQFAIVSDGGKVVNRPVVGGERKQFGESMSSEIAKVLGLDYEKLRVAAVVQQGELARIVEAQPKEFKELLNGLIGIDRLDLAYETMRDVIVGFRDRLRDETGGYTDQDILKVEELVGKKEIELRQSESVLAEFEDERKMLEDKIRQAEREIERMEPMILQVKELHTREELLVRHVNEKRAAIASEVSRLERIVREAASSLKVLKNKAEVDMRLQMVRAEIDEVQSKIEENERASGVLRGFLECSSRLQVVDGKCPVCNSPVTKVNEMFDTAHIQDEIKDRAEEKSGLQKSKVELKKEEQQLAEQDKKIAAAEKFLLNNSIGSADDVAKLEADLKGKQQDLARLPKEILKAGDDPMQIAIDDTSRSLAREIISLRERVRGFSHYQYTNAKLEKSSLSQRLLDVNRKMGMHQKAIDDAKSAIDSGRKVIEQLQKAAEFVKTLDKIRSVIFSRDGMVGTSLRTWALGVISQKASEYASLFNIGISRIELAEGAREISITCYGRQGEIDMDSLSGGEKVAVALALRLGIAYMMGSNKLDFVILDEPTTHLDEERRKALVRIISEAFREGAGPLAQLVIITHDSDIFEDSEVDQVFRFTMTADGSQVTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ9</accession>
    <name>K0IMJ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella protein FlaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flaH</name>
        <name evidence="2" type="ordered locus">Ngar_c10120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10120"/>
    <dbReference type="EnsemblBacteria" id="AFU57954">
        <property type="protein sequence ID" value="AFU57954"/>
        <property type="gene ID" value="Ngar_c10120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10120"/>
    <dbReference type="HOGENOM" id="CLU_094838_1_0_2"/>
    <dbReference type="OMA" id="DCHLFLR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="25618" checksum="80742595A8702122" modified="2012-11-28" version="1">MAIITVSTGNEEVDRQIGGGLPLPSLMLIEGDHGTGKSSMAAQFMNGLLKSQRKVLFITTESATKDYIEKMKMITYDFRRDFLKNMLSILPVNIDGVSWSAARSKQLLPVVGKYISINSKKFDAVVIDSLSALTMHADTSTTLDFFTKCKNFVSKGMTVIITIHPKAVPEEVAMRVRSTCDGYMKITPATIAGKSVKVMEIVKLIGSSSQVSSQFSFDVDTSFGIKIVPLSMANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN5</accession>
    <name>K0IMN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60437">
        <property type="protein sequence ID" value="AFU60437"/>
        <property type="gene ID" value="Ngar_c35240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35240"/>
    <dbReference type="HOGENOM" id="CLU_067489_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3525-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="356" mass="38334" checksum="F73C85406B586593" modified="2012-11-28" version="1">MYTIRVKSNNIPAAVISSAVAALLIVGLANQAYAAQINASLIPEFDRAAGSFIGVKFVQMRYEPGSAVADLFNGRTERIEFSIPGTNSSGIDRLIAAANQALLRVQSPVQIVSANLTYSGAIRGEADRLMLTYSVEFIPTFSGFKLDRNATDNIPIDINWRGFVIDGPVLVDSPEHGTVNVNQPIGLLSLAFPEFAEGLAGSSEEARQIMEEPILDFSEVGAMSMERWHWLFDPTWSQASTGGILSGEGIGRAKVMSVYSLGECSIREGCPPPKESDTTVSIDGTPVQVHISTPQPNSQIEIAGFTSIEKAGGQEIIRVEMDNPSLSLPPFTMQVLMVLAGMMGAIAFFVLFKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP0</accession>
    <name>K0IMP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11220"/>
    <dbReference type="EnsemblBacteria" id="AFU58064">
        <property type="protein sequence ID" value="AFU58064"/>
        <property type="gene ID" value="Ngar_c11220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11220"/>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1120-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="16268" checksum="BF1DAE9186F94104" modified="2012-11-28" version="1">MSDDNNSKRSKKVPIIAAIVTGIVLAVATGLIINTTLPRNTFGSDILHPPQSVTIIIPANASIPDANPTFSPKEITVVLGVNNTVVWINQSNSPERVIGEDVNAPGDFGKIRSLIEAGGGTWAFTFTEEGTYNYLSDIHPWLKGTVIVKRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN36</accession>
    <name>K0IN36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17560"/>
    <dbReference type="EnsemblBacteria" id="AFU58689">
        <property type="protein sequence ID" value="AFU58689"/>
        <property type="gene ID" value="Ngar_c17560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17560"/>
    <dbReference type="HOGENOM" id="CLU_965111_0_0_2"/>
    <dbReference type="OMA" id="QRQMEGI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1754-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="94"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="288" mass="32743" checksum="58B9F8B9FE5F5B0A" modified="2012-11-28" version="1">MFCVQKRQNVARSFLTVDSGQKWRKPSFCRSLPSRSKKDPFLDWSKTCPVFLLLILLGCSFGGHLLSSPFLNGLSHFVDNVPVKLFYLAGSMKYAFAYLRVSTEEQTVQNQKLALEKWAQENNYQILDFFEDSAVSGKVPATQRRGFQEMLELIKTAGVDAILVYELSRVGRTFWDTLDAIKAIEQYAPLISCSPRESFLQTTEPSVRKLMIGILTWVAEREREMLVQRTKDGMERARAAGKGIGRPQKVIDKNQLITLLAENHSKAKIAKNLGVSKATLYKELRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN84</accession>
    <name>K0IN84_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UpsA-like archaeal pilin, upsA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58929">
        <property type="protein sequence ID" value="AFU58929"/>
        <property type="gene ID" value="Ngar_c19970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19970"/>
    <dbReference type="HOGENOM" id="CLU_1736473_0_0_2"/>
    <dbReference type="OMA" id="MTRVKSR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1995-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="15506" checksum="A431BEFB2B2E9117" modified="2012-11-28" version="1">MNHLLGKLKSDRRAISPILATIVLIAITVAGGLLVYNVFFATAGAVAARTQIEIESVNMVKTTSGATVFSITLQNTGNKFLNSVTYTVTGDTGTLTATLNNLQPGQSLSDTKTNPAGFSVTPGKTYPVSITATASDGSTAQYTSSVLASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC0</accession>
    <name>K0INC0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59109">
        <property type="protein sequence ID" value="AFU59109"/>
        <property type="gene ID" value="Ngar_c21790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21790"/>
    <dbReference type="HOGENOM" id="CLU_3057250_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2177-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6165" checksum="087299EBCD29F97A" modified="2012-11-28" version="1">MIEEWWQEKPFEGSYICPFQKALFQSHPHARHAKHTVMATHDVVVDLSETLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF4</accession>
    <name>K0INF4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheT</name>
        <name evidence="10" type="ordered locus">Ngar_c23540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23540"/>
    <dbReference type="EnsemblBacteria" id="AFU59279">
        <property type="protein sequence ID" value="AFU59279"/>
        <property type="gene ID" value="Ngar_c23540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23540"/>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_2"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="9">
        <location>
            <begin position="270"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="545" mass="59738" checksum="5BD650823837EE24" modified="2012-11-28" version="1">MSVERLKKFIPGVKVDKVLDMLPFVALDIEGIDDNNNVIRVEYNPNRPDFSSDYGIARALRGLLEIETGLPKFRIAGKSGAAVKVDPTVKKIRPHIVALVARNSKLDDETIKQLIAMQEDLHNGIGRRRKKASIGIHNLDAIKFPVTYKAVDGDYSFEPLGESSSRSIDQILKESEAGRQYGHILEGSGRHYYPVIIDSDGMTLSFPPIINGNATKVDESCRNLFVEVTATDQKAAEDVLAIIAVTLYDAGFEIRTVAVGAGKRAETPQMKPKVISADIDYINSILGLTLDARQVVKCLKKSRLDARAAGKRIACTVPRYRTDISHPIDIAEEVAIGYGIFNIEPVFPASPTAGQKNSLSTYFEAIRETLTGLGMLESLSFSLTSKEVQYEAFGITTGRDALSVDGSKSIEHEILRDSLIPSLLQSLSRNVHEEYPQRLFEIGKTFRKDDSITESWNVGAVIAHADAGYTEIRSAMQALIRSCFDKDTTTKTSSSPMFMEGRCAEIVIDGAVAGTIGEVTPLALENFKLRVPAAAFEIDLSKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM8</accession>
    <name>K0INM8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59649">
        <property type="protein sequence ID" value="AFU59649"/>
        <property type="gene ID" value="Ngar_c27280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27280"/>
    <dbReference type="HOGENOM" id="CLU_2930316_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2728-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6972" checksum="7C4CBEB240A2B52D" modified="2012-11-28" version="1">MEWWQIVAIIVPIVTGLGIAAIKVSNSMRKVESLKFKPRFLCPHCSRYYETIETHLCHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT1</accession>
    <name>K0INT1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase</fullName>
            <ecNumber evidence="1">1.2.1.103</ecNumber>
            <ecNumber evidence="1">1.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argC</name>
        <name evidence="1" type="synonym">lysY</name>
        <name evidence="3" type="ordered locus">Ngar_c29960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in both the arginine and lysine biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:41948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="EC" id="1.2.1.103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:52668"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="Rhea" id="RHEA-COMP:13327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:136761"/>
            <dbReference type="EC" id="1.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.103" evidence="1"/>
    <dbReference type="EC" id="1.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29960"/>
    <dbReference type="EnsemblBacteria" id="AFU59914">
        <property type="protein sequence ID" value="AFU59914"/>
        <property type="gene ID" value="Ngar_c29960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2968"/>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_2"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00037"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043870">
        <property type="term" value="F:N-acetyl-gamma-aminoadipyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02083">
        <property type="entry name" value="LysY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037535">
        <property type="entry name" value="LysY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="350" mass="39119" checksum="BA3571DFA9ECBE97" modified="2012-11-28" version="1">MKVGVVGASGYVGGELLRLLVTHPKVEVNMVTSRQKAGEYVHRVHPSLKGFIDITFSPMDTEKLANSCDLVFTSVPHGKANKIVKDLYDRGMKVIDLSADFRLKNPKDYVRWYGWEHPFPDMLSKSVYGVPELHREEIKKAQLVSCPGCMAVTSLLALKPLIENNLIDTDHVVVDSKIGSSGAGQKANAGTHHAMRYGVVRPYKPAKHRHTGEIEQELSMIAKKQIKVSMSPHAVNIVRGILTTNHTFLKRQVEELELWKMYRNSYKGEPFVRLIRDKKGLYKFPDPKFVVGSNFCDVGFDIDEYNQRIVALSASDNLMKGAAGSAIQVMNVMSGYDETEGLKYTPLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT9</accession>
    <name>K0INT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59954">
        <property type="protein sequence ID" value="AFU59954"/>
        <property type="gene ID" value="Ngar_c30380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30380"/>
    <dbReference type="HOGENOM" id="CLU_2784241_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3038-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7572" checksum="78218324BFD23D88" modified="2012-11-28" version="1">MSLHNETASRGNFTTGQSWGALRKAWKGYRIAKVQGDNAKMREYATKIRKLQGELGISVASFPHLGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU9</accession>
    <name>K0INU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60004">
        <property type="protein sequence ID" value="AFU60004"/>
        <property type="gene ID" value="Ngar_c30880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30880"/>
    <dbReference type="HOGENOM" id="CLU_2712976_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3088-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8311" checksum="C8CE0DBC66E5D52C" modified="2012-11-28" version="1">MLFVSIRHRTRTVLEEKLGRAQCVVMFYEKVILASMPLADNDLVLVTVDTSARNFQDIMRKVLKLIGKYIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV7</accession>
    <name>K0INV7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60044">
        <property type="protein sequence ID" value="AFU60044"/>
        <property type="gene ID" value="Ngar_c31280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31280"/>
    <dbReference type="HOGENOM" id="CLU_2839488_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3128-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7787" checksum="C8B288539CA285AC" modified="2012-11-28" version="1">MIIEDAEVVSYKMIIKTAEWFGIKDDAIISPLKQTLREEERMAQWLMDNSPSILDYHWSKRLKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP05</accession>
    <name>K0IP05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c33690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60284">
        <property type="protein sequence ID" value="AFU60284"/>
        <property type="gene ID" value="Ngar_c33690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33690"/>
    <dbReference type="HOGENOM" id="CLU_032903_3_2_2"/>
    <dbReference type="OMA" id="WSVVYDK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3369-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010094">
        <property type="entry name" value="Transposase_put_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01765">
        <property type="entry name" value="tspaseT_teng_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="279"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="373" mass="42403" checksum="F38AE55624F58C59" modified="2012-11-28" version="1">MLQALPVKLETSDDEKALLLATMRKYNEAANFLAEQAFRLKIANKVELQKRFYYQLREQFNLSAQFAVRVISKVVEAYKRDKSIKPVFRELGAIQYDQRNISWKGLDKVSLITLKGRIKLRTRIGEYQKARSDRIRGQADLIYRKGEFYLIAVVDAPEESEFDPIGAIGIDLGIENLATDSDGQVFSGEKVEKVRKRYNGLRARLQKKGTRSAKRHLKKMSGREKRFKRDINHVISKAIVSKAKGTLRAIALEDLSGIRSRATVIGRKQQRDRHSKWSFRQLRAFVEYKAKRDGVPVKFVDPKNTSRECPKCHNIDARNRHTRNHFKCTECGYEAMADHVAACNIAARAAVNQPIVAPLFSAVTSPPALAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP10</accession>
    <name>K0IP10_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hemolysin-type calcium-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60309">
        <property type="protein sequence ID" value="AFU60309"/>
        <property type="gene ID" value="Ngar_c33940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33940"/>
    <dbReference type="HOGENOM" id="CLU_1286377_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3395-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="22125" checksum="971A2C2612B2B49F" modified="2012-11-28" version="1">MALLLAVPSTTAMVLAATTVYGTSASDTLYDTAEGDTIYGYGGDDTIYANQGNDIVYGGSGNDQITEGPGGDSRIYGGSGDDEIVTGYGYDVVYGNSGNDKIHDIGSALIYGGAGNDNLDGSKYADTIYGGSDDDWINGRLGDDRLNGGAGNDEIIGWDGNDILRGSGGNDILTGDGPDSNTGADRFYCGDGIDTITDYNPAEGDWKSSDCENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6V8</accession>
    <name>K0I6V8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56986">
        <property type="protein sequence ID" value="AFU56986"/>
        <property type="gene ID" value="Ngar_c00360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00360"/>
    <dbReference type="HOGENOM" id="CLU_168025_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-36-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13027" checksum="E03475A901CD144D" modified="2012-11-28" version="1">MCKRGEEYHTCVSCGKYLCISCFNTVHFEIGAPRAGRSMVYNKCLFCNVVYAANAKGSVCDKCEVILTWKSSMNYLAAVNRVSELLRKGDLDSKLRNENYCKTSFGVQCRAGNNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7C6</accession>
    <name>K0I7C6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative permease, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57161">
        <property type="protein sequence ID" value="AFU57161"/>
        <property type="gene ID" value="Ngar_c02130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02130"/>
    <dbReference type="HOGENOM" id="CLU_3003261_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-213-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6286" checksum="255C3F30D712F1EC" modified="2012-11-28" version="1">MLNSTVFIGFLGFVLVLPFIFFYAESFGASSFVFGLLLASYNIAQFVFYADRGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7X5</accession>
    <name>K0I7X5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57366">
        <property type="protein sequence ID" value="AFU57366"/>
        <property type="gene ID" value="Ngar_c04190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04190"/>
    <dbReference type="HOGENOM" id="CLU_2447762_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-418-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9722" checksum="BFBC55858753CB34" modified="2012-11-28" version="1">MDERPLDGSADAVAVARSFLLAKLPELGIHINDELDLHTDMVVAETESEYRVDFGLTDSEGRSHEGYAEVANGEVVFAVIDGRTIHSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I944</accession>
    <name>K0I944_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57836">
        <property type="protein sequence ID" value="AFU57836"/>
        <property type="gene ID" value="Ngar_c08940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08940"/>
    <dbReference type="HOGENOM" id="CLU_1105238_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-892-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="251" mass="28135" checksum="608A58CA11BFB76E" modified="2012-11-28" version="1">MAPTLFRSESVLFGILYLIGCIPWPTPVGKKRGHPYVYSPTVILRCFIVRIWFRIDSNNALHKFLEIDSPYNRKLLTVCSLASIPDRRTFDRRLKTISADIMQRIAAMGKLFAAEKLVDPYIVTADSTLLRARGAVWHKSSMKKGEVPHSGIDTDARWAIAVLKVGCLVTKAARGIKYWSSRSAAVSADFTTANVPDNQMYVPLMSSLPPGTRYTAADSGYDDQKLYDYSSKVLGIGLVCPIERYEHTPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I956</accession>
    <name>K0I956_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57856">
        <property type="protein sequence ID" value="AFU57856"/>
        <property type="gene ID" value="Ngar_c09140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09140"/>
    <dbReference type="HOGENOM" id="CLU_2257454_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-912-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="10861" checksum="7A519509018DA9E4" modified="2012-11-28" version="1">MISIDIIANTVTGRVSTTSPVVVGIASDGTFGPAYFAEFPLARIQITNTVFLNTAGAGISQAGVGQQVSIASTFTNQQQVSQKYAFIVMLIVDQNGYAIDVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9D1</accession>
    <name>K0I9D1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57946">
        <property type="protein sequence ID" value="AFU57946"/>
        <property type="gene ID" value="Ngar_c10040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10040"/>
    <dbReference type="HOGENOM" id="CLU_173008_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1002-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="12308" checksum="49FFDE2F4B02F9D1" modified="2012-11-28" version="1">MPKKDGLMVAADILKLAPEQRIIFVSAYVKEFVEKPVRQLKADIEVFQKPVSPRTLVEVVEDKALYEEIERLGGNAKKIREEMNPTHRQLKQLVESMRKLRAKYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9X6</accession>
    <name>K0I9X6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58131">
        <property type="protein sequence ID" value="AFU58131"/>
        <property type="gene ID" value="Ngar_c11910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11910"/>
    <dbReference type="HOGENOM" id="CLU_188388_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1189-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018592">
        <property type="entry name" value="DUF2024"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023122">
        <property type="entry name" value="NE1680-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09630">
        <property type="entry name" value="DUF2024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160766">
        <property type="entry name" value="SSF160766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12368" checksum="33CE183B1C7C74AF" modified="2012-11-28" version="1">MQSKLEPYNGSGKKVVVYNTYADKGRLHFDVFIPTDKSQASQVSKDVDAKAVEYAKEFLHLIGKPSDDIEVNMCERCHIDNTDLYASELWKLPGKEVFIWPMEGCPKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA46</accession>
    <name>K0IA46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor TFB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb</name>
        <name evidence="6" type="ordered locus">Ngar_c12360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12360"/>
    <dbReference type="EnsemblBacteria" id="AFU58176">
        <property type="protein sequence ID" value="AFU58176"/>
        <property type="gene ID" value="Ngar_c12360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12360"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="YSNERET"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="366" mass="40392" checksum="28A7D38E4A2EF214" modified="2012-11-28" version="1">MLARQEPDSLDLCVVCSGQLISDPDTGEEVCSSCGVVARENLELAAERRAFTLEEMDKRYRTGEPASLMMYDMGLSSFIDNKNIDANGKQIQGYTEIDRLRRLNKITVSNNSKTKNLNKAMREIRRITEILGIGTPVAERAAYIYRKALEKELIKGRSITGIVAATIYIACKDTGTPRSIHEIQEVIGNADRKNISYYYKFLLREMKIHVPLPMPSNSISRIADKARLSEKTVRKALEILALVGDNAMLSGKNPVSLAAASLYLATIETSEYTTQLRIAIAADVSTVTVRKRCLEMIQLVKAANSQLLPKSIEKSQELLAEEPKTAAAQQLPVASSATAHQPPAKNVKGLFLASRQVPHLPDLPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAW2</accession>
    <name>K0IAW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58471">
        <property type="protein sequence ID" value="AFU58471"/>
        <property type="gene ID" value="Ngar_c15370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15370"/>
    <dbReference type="HOGENOM" id="CLU_1881147_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1535-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="14493" checksum="3EE9377A2A5C9089" modified="2012-11-28" version="1">MYHLQKSDLRKKKASEALAIVGMALLTIDTAGTLMGQGGNRFLPLTDRQSGILLGLPSIILLFLSFGIVGLRQKIRITTVLLMAGGAMLAVSKLIEPTMGLILFLAVALPYVYVSLIASGFILIGLGLLRAIRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAY1</accession>
    <name>K0IAY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15620"/>
    <dbReference type="EnsemblBacteria" id="AFU58496">
        <property type="protein sequence ID" value="AFU58496"/>
        <property type="gene ID" value="Ngar_c15620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15620"/>
    <dbReference type="HOGENOM" id="CLU_2629849_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1560-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="9268" checksum="DCE0FCD1A59D0B8D" modified="2012-11-28" version="1">MPVRNKTMIKPDMPVLDTAKKYLVIDNIYDTGDTYHKVIDALTEFNCDFAFCMSRYKRHWITAKVLDHNRWIVFPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB05</accession>
    <name>K0IB05_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">purQ</name>
        <name evidence="2" type="ordered locus">Ngar_c15880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15880"/>
    <dbReference type="EnsemblBacteria" id="AFU58521">
        <property type="protein sequence ID" value="AFU58521"/>
        <property type="gene ID" value="Ngar_c15880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1556"/>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_2"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="25194" checksum="4CF7DF28415E824A" modified="2012-11-28" version="1">MAKIGIVVFPGSNCDRDVHHVLNNVIGVQADFLWHTKDRISSYDAMIIPGGFAFGDRLRAGIIAAHSPIIQEVKRMAKDGMPVLGICNGFQILVESGLLPGALMMNDSLRFVCRWTKVEVKNNKTPFTSQFAPKQTFAIPVAHGEGRYMADSKIIKDLKKKNQIVLQYSNDDPNGSTNLIAAICNEEGNVMGMMPHPERASESILAAEGAGNDAITIFRSLVSNLKQKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICE8</accession>
    <name>K0ICE8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 1-alpha</fullName>
            <shortName evidence="5">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor Tu</fullName>
            <shortName evidence="5">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tuf</name>
        <name evidence="7" type="ordered locus">Ngar_c02920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02920"/>
    <dbReference type="EnsemblBacteria" id="AFU57240">
        <property type="protein sequence ID" value="AFU57240"/>
        <property type="gene ID" value="Ngar_c02920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.285"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_2"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="437" mass="47589" checksum="A51C328DDFBEFF39" modified="2012-11-28" version="1">MSASKKPHMNLVVTGHVDNGKSTTVGHLLVDLGAIDQRTIDAYAKESEATGKGDTFKYAWVLDSIKDERERGITIDLAFQKFETPKYFFTLIDAPGHRDFIKNMITGASEADAAILVISVKPGETEASIEPGGQGREHAFLARTLGVNQIVVALNKMDDVGYQEARYKEVKDNVEKMLKMVGYNTAKINFIPISGWKGDNLVKQSTNMPWYKGPTLAQALDALEPPEKPVGKPLRVPIQDVYSITGVGTVPVGRIETGRMKANDKVIVMPSGAVGEIKSIETHHTQMESAEAGDNVGFNLRGVDKKQIKRGDMIGPADNPPTVAKEFEARLIVIHHPTAIAPGYTPVLHTHTAQVAATISAFVSKIDPRTGATTEQNPKFLKTGDAAIVKIKPVRPLPIETFKDFPEIGRFALRDMGTTIGAGVVLNITEKYDPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICT6</accession>
    <name>K0ICT6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57470">
        <property type="protein sequence ID" value="AFU57470"/>
        <property type="gene ID" value="Ngar_c05270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05270"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-525-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11408" checksum="C8A37A14D280022B" modified="2012-11-28" version="1">MKYRSRTDITAQILEAANGGCTKAKIMYRTFLSYVQLRHYFVLLVEKDLLEYDGATQTYKTTDKGHRFIQAYNQIGGFIAARQERRGQQYQRAFKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDP0</accession>
    <name>K0IDP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57820">
        <property type="protein sequence ID" value="AFU57820"/>
        <property type="gene ID" value="Ngar_c08780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08780"/>
    <dbReference type="HOGENOM" id="CLU_2646043_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-876-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8596" checksum="D5A99463873DB50F" modified="2012-11-28" version="1">MALEDTIRTLQELGKRKPLQGEEKRQSEEAASASREFGFTDRHSSILSNGGFAETTIKEKARGARVKDRSVMDRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDT9</accession>
    <name>K0IDT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59551">
        <property type="protein sequence ID" value="AFU59551"/>
        <property type="gene ID" value="Ngar_c26290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26290"/>
    <dbReference type="HOGENOM" id="CLU_1478961_0_0_2"/>
    <dbReference type="OMA" id="TSGHENE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2629-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="19570" checksum="0EBA23972A19FE8E" modified="2012-11-28" version="1">MNTKAIYAVGGGIAAVAIAIFFILGSGNLRLPGGGQENAAPIPVTDLQIVLKDIAVQRVDERNANVQVVFTAHNPNRSTAVLETIHYTVFVGEFQMTSGDIGVSPEGFVAGQPDTFPIVSNATITLRDTKVAVRNSLTASSWDSMVDGTAQFRVEGAYTYRLTGSNFQTSYFENKEFTLTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDU9</accession>
    <name>K0IDU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56993">
        <property type="protein sequence ID" value="AFU56993"/>
        <property type="gene ID" value="Ngar_c00430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00430"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-43-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8446" checksum="5EBD4A33C2B0F8DB" modified="2012-11-28" version="1">MIMISAIVLVNCRFPFDADVIAELNKLSAVSHVYRTSGIYDLIVKVSADTENSLRRTVCVDIGTIRNVDSTVTMVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV3</accession>
    <name>K0IDV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57920">
        <property type="protein sequence ID" value="AFU57920"/>
        <property type="gene ID" value="Ngar_c09780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09780"/>
    <dbReference type="HOGENOM" id="CLU_1718270_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-976-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="17818" checksum="B25A0841B0A18429" modified="2012-11-28" version="1">MLEQNNISSNSMISFEQIAPRWSKRLQHFPPPLFSANNISWGLQIAFADTCVVGEAHGFSGEYVQECSECRQIGFELVSSYFTRSAERMHRNIELFTLHWNKCHYHHLLDNTKKNRRRRQQQKQKRKELVIQPEEEGKDTLPIIPITTVMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEJ7</accession>
    <name>K0IEJ7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.147</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cofH1</name>
        <name evidence="11" type="ordered locus">Ngar_c12350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12350"/>
    <dbReference type="EnsemblBacteria" id="AFU58175">
        <property type="protein sequence ID" value="AFU58175"/>
        <property type="gene ID" value="Ngar_c12350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1185"/>
    <dbReference type="HOGENOM" id="CLU_040406_1_1_2"/>
    <dbReference type="OMA" id="ATMMFGS"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="63"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="421" mass="46393" checksum="F878578BD44E095D" modified="2012-11-28" version="1">MSMLDSLLKRADPVVAAALERALSGKDISVDEAVALFDSTGLEMNLAVMVADELRRRTVGDDVTYVINRNINFTNVCIKQCGFCAFSRDFREEEGYFLPTEEIVRRAKEAAGLGATEVCIQAGLPPKMDGNLYADICRAVKKELPDMHIHAFSPEEVMYGAIRSETPVPEYLKALKEAGVGSLPGTAAEILDQSLRDIISPGRISVQDWVAVIKQAHTLGIPTTSTIMYGHVETSRHKAEHIALLREIQKETHGFTEFVPLSFVHTEAPMYSHGTVPNIRAGADGNEVIKMHAVARIMLNNHIPNIQVSWVKEGARMSQLLLAAGANDFGGTLINESISTAAGAQHGQLMKPKEIRQLIRSAGRTPVQRSTTYRVLKVFSDEKEDDQESALDSADASQFGSYHQLIKLDKFRYNNNKDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEK6</accession>
    <name>K0IEK6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c02550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02550"/>
    <dbReference type="EnsemblBacteria" id="AFU57203">
        <property type="protein sequence ID" value="AFU57203"/>
        <property type="gene ID" value="Ngar_c02550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02550"/>
    <dbReference type="HOGENOM" id="CLU_039453_4_1_2"/>
    <dbReference type="OMA" id="VEYREQG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-255-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20994" checksum="C7B269F5EA5CF1BD" modified="2012-11-28" version="1">MVSDDDLSPFFRSVLQLKSVRRAGWVSKVKVKDAESVADHTFSMCAMAMLLSDMLGLDTHRVVKMVILHDLAESIVGDYMPGDVSANQKLAKEKRAMKSILSGLPEKVRTEYEQVWLEYLQNKTEVARFVHRIDKLEMALQANQYAKQGYADRLLAPFFESARTAVGDEGDIVSEILNSLRPASAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEL8</accession>
    <name>K0IEL8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ald</name>
        <name evidence="6" type="ordered locus">Ngar_c12550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12550"/>
    <dbReference type="EnsemblBacteria" id="AFU58195">
        <property type="protein sequence ID" value="AFU58195"/>
        <property type="gene ID" value="Ngar_c12550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1201"/>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="4">
        <location>
            <begin position="186"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="395" mass="43474" checksum="E7C28A739EC4F36A" modified="2012-11-28" version="1">MIIGIPREVKDYENRVALTPRSVSSLVGSGSKVLVETQAGAKSGFSDDEYSSAGATVVGSQAELYGKADLIVKVKEIQVSKSEHERIRPEHTIFGFNHFESSRELTDAAVRSRATFISFEKVVDERGQTPLLMPMSRIAGTVSGIWAGFFHNYAFKHDKSIRLKTGADQVKSKFVEGFEHIVNVSIDNELKRMLSLHDKMAVIFGGGNVGEMAARVCSALGAKVTIVEKREARRKYLQELKLPKCSVAAVADRDILRGAYVIIGSTYDKEKADRVIDEKLLKEVSEMRKKIIIDVAVDQGGNFPYINPSGEYSPSSTGTILNPAQTDYFGNIFIRVPNIPSIVPRYASTTLSAIIAEYIKDIVNNVPRPELVRAISIKGGKVLDEAIIKAHNLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM3</accession>
    <name>K0IEM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58200">
        <property type="protein sequence ID" value="AFU58200"/>
        <property type="gene ID" value="Ngar_c12600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12600"/>
    <dbReference type="HOGENOM" id="CLU_2679063_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1258-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="7972" checksum="E6A6A26934A1D7EE" modified="2012-11-28" version="1">MSEKNTTSFNPAGILTAPFVIGTAALEMTLMTTLSLARVAQIAVQSADTALAKYIELTEQEIKKGSRRESVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP3</accession>
    <name>K0IEP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS116/IS110/IS902 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57253">
        <property type="protein sequence ID" value="AFU57253"/>
        <property type="gene ID" value="Ngar_c03050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03050"/>
    <dbReference type="HOGENOM" id="CLU_036902_12_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-305-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12261" checksum="51C6727B9246C0CB" modified="2012-11-28" version="1">MLISAEIVDIRRFPTPWKLVSYAGLAPGTRESVAGKSKKGWITKQGSPWLRWTMVQCAQVAARHDPRMKAFYERLRSKKGAAKAITAVAKEMLVILWYMLTRRHSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEZ7</accession>
    <name>K0IEZ7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nirK</name>
        <name evidence="9" type="ordered locus">Ngar_c04260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04260"/>
    <dbReference type="EnsemblBacteria" id="AFU57373">
        <property type="protein sequence ID" value="AFU57373"/>
        <property type="gene ID" value="Ngar_c04260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04260"/>
    <dbReference type="HOGENOM" id="CLU_031740_1_1_2"/>
    <dbReference type="OMA" id="FHAAMVS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="430" mass="45187" checksum="7F1B4492331B1314" modified="2012-11-28" version="1">MPAMNKPVIAGIVAGVLLAGFAVLSPITGLNFDVEAQSTGTTKKVTLIADEVDVQVAPDNALHPGGVMYRAMVFNGTIPGPVISVDQGDTIEFTLINEGEVIHSIDFHAGHGPNDAVGANASATGSTVRSGESVTWTWKPPFAGVFFYHCGADGLNGVWEHIANGMYGGIVVHPPNEQPAKEFYVVFGEIYSNNVEGVFTQANGTGSFDVAQFLTGNPDIVMTNGMAHRYVPALGAIAKIDINPNATIFQVKPGELTRWYIVNAGPNDGIAFHFISGMIDVRDGSIKNRYGTQLKNDETWWIPPGSGSVIEATFPQEGVYVGVDHAMNDVVKGAAFAVLATPDATDDDHPPGTMVPPRGSDRVTSPTTFEETRPAAEQAEEFEPPTGEATTETTNATDTGNQTGTGNETDTAGNETSSAAGNDTNTNSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF58</accession>
    <name>K0IF58_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57448">
        <property type="protein sequence ID" value="AFU57448"/>
        <property type="gene ID" value="Ngar_c05040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05040"/>
    <dbReference type="HOGENOM" id="CLU_1830649_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-502-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="16907" checksum="84081F2A97ADF8BC" modified="2012-11-28" version="1">MGLIQEKLDLLSSMIYHLDKMKYKYDAIAFMHQQTTPQERYAFNQDEWNELVRDIDEKIKNRYYLLNRKVLEKWVWAKNLRTHPKSIEIMPELRKMLVEEYNQIIDKHLNNLQDIVPKITPDEETGSRDKQTDAQESPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF61</accession>
    <name>K0IF61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c05090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57453">
        <property type="protein sequence ID" value="AFU57453"/>
        <property type="gene ID" value="Ngar_c05090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05090"/>
    <dbReference type="HOGENOM" id="CLU_027562_2_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-507-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="484" mass="55405" checksum="A46FE5E8DCDADEC4" modified="2012-11-28" version="1">MTESDSSNSAFLVQNKSTSRQQQKKKKEKEVIDAAALEQKIQQAAGLQPGHVIKALKSLTPENTSILCDYIIAEQSTINISEVTKTSKILHLAYLPKHCGNKSFREMTASDIQAYLDSGRKSEEEDPLHKWIGYYNSKVKEIRKFFKWLYQSEKPQEERELPAFLTHIRKLRRKEASIYTPFDLWTRDDIAIFLKYCPVKRDRCYVAMAAEDTGCRPHELLKLKIKDIMFKVSANGKNYAEIVVNSGKTGQRHLPLFSSLPYIKEWIADRPFGGNPDSYLFVSLADQNFGERLKTHGLSQKFWRYYRDIFFPKLLKSDQVPEEDKAKIRTLLQRKWNLYVMRHTALTRAARLLKDGATLREHAGWSLNSKMPMTYIHWFNNESGESLLQAWGVETKAKGEEEKLVPKVCPECMASNRPDALSCYNCKQVLTRESYLEAKNFEQTMKAQVSNLEKEIQEIRKAVGGIKTDAGSSSSSSGGDGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFC3</accession>
    <name>K0IFC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c15770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58510">
        <property type="protein sequence ID" value="AFU58510"/>
        <property type="gene ID" value="Ngar_c15770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15770"/>
    <dbReference type="HOGENOM" id="CLU_617689_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1575-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="443" mass="51230" checksum="0AC16FF7380429F5" modified="2012-11-28" version="1">MVRERMWEPQHAYAAFFWNREHPDRFSIRDVAGLIKSEFGRHYSKSSVSNMVADVEQALKSGNEQAKQDYEKVKLELTTGKKYFWRYDADGKVDSPYEVVKSVAERIYGRGNYYPDWFLDQLNVAERFWQFVGKKNPKDWTEQDYNKYIGTVGAGSKYTHTIAIRQFGQQIKDIDDLTRGLKPAPRKPKLLKLPDFPQLYQKIVAKAVEIARPEEREQIEFILQVKPRIGVRTGARETGKGLWGTKVGGEWKNKRGKNASFVQVVGNNFIWHLLEKKDEEWDINFYNAETKKRIIDYVSKKQAGEWLIEISISRVSRILKEACLALGIGQFRKDDAGNIVKDKLNRPIIDNALRLHDLRKVYISFLVRSGIRLEQAITLNVGWRDIGTAAKYYLEFQELAEELQKAKERFAALFGEKGEGGALPEAKHEHESGEDDDEEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFH3</accession>
    <name>K0IFH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60116">
        <property type="protein sequence ID" value="AFU60116"/>
        <property type="gene ID" value="Ngar_c32000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32000"/>
    <dbReference type="HOGENOM" id="CLU_2629858_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3200-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8895" checksum="4EB455889B0371C5" modified="2012-11-28" version="1">MNLKHIALQLCTCTWIEIMTGAGITLYMLYLGSYTLAVITVGVFAPLILFHFAMDQLPKSNVEWQQKRPRRRIKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFS7</accession>
    <name>K0IFS7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33210"/>
    <dbReference type="EnsemblBacteria" id="AFU60236">
        <property type="protein sequence ID" value="AFU60236"/>
        <property type="gene ID" value="Ngar_c33210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3311"/>
    <dbReference type="HOGENOM" id="CLU_1582945_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3321-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="18977" checksum="526B5A47440C7F69" modified="2012-11-28" version="1">MGERSRGCDRVSLVLLLHLQQRADRQKRDRHRADGPEKLKILYYPDDIFVYADREKMIEVIANLITNAIKFTKEGTITVASKVGREDNMVQVTVSDTGTRIDPEVMPKIFDKFVTKLDSGTGIGLYISKKIVEVHGRVMQAANRQDCRGAIVSFKLPLTKTSELPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFU2</accession>
    <name>K0IFU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60261">
        <property type="protein sequence ID" value="AFU60261"/>
        <property type="gene ID" value="Ngar_c33460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33460"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3346-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10415" checksum="CAF5A3AF5627D6E1" modified="2012-11-28" version="1">MPKSLMLIGVDLGADKEVLEEVRDHAAISEAYRIIEDESEMYSIIAKVESDTRDDLDAIETKIRRIEQVRSTLTLEIIEGKRDNESRPLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFU3</accession>
    <name>K0IFU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Minichromosome maintenance complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mcm</name>
        <name evidence="5" type="ordered locus">Ngar_c07300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07300"/>
    <dbReference type="EnsemblBacteria" id="AFU57673">
        <property type="protein sequence ID" value="AFU57673"/>
        <property type="gene ID" value="Ngar_c07300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.705"/>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_2"/>
    <dbReference type="OMA" id="NAYTCDR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="4">
        <location>
            <begin position="295"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="690" mass="77086" checksum="0585EB55C9818CCF" modified="2012-11-28" version="1">MAEQQQTAAALANDLEKFLKAFKDRDGNYKYFDRINNMMALGAQSLVIDYIDLDSFSPTLAKEITHQPDEYFAAFNEAVLSILREIHPDYEQEIREKVRVRIGNYTVQKGLREINADLIDKLVSVSGMVVRSSEVKPLAKKVAYRCTNCNTVTEAQLKGLVLKKPQKCHACSEKELEMDPENSLFIDFQMVRLQELPEDLPAGQLPHYVEVTVMGDLVDQCRPGDRIMLTGIIRIEQEQLAPQAKTSLFRLRMEGNNIEYLGGRAGSKDTRTVERIAISAEDERQIRAIASKPDAYEKLIASFAPHVYGHEVIKEAILLLIVGSVTKKLEDGSTRRGDINLLLVGDPGVAKSEMLKFAAKIAPRGLYTSGRGSTAAGLTAAVIRDKSGIMMLEAGAVVLGDQGLVCIDEFDKIKPEDRSALHEVMEQQTCSVAKGGIVATLNARTSIMAAANPMYGKYDPYKNITENVNLPVPLLTRFDLIFIVRDMPEKEKDNLIASHILEIHKDAEHAAKPAIEIDLFSKYLSYAKQGEPLLTPEAIDIIRSYYMEMRKVESEGMITVTPRQLEGLVRLATARARLLLKDKVEAEDAQRAIYLVDQMMRTAGVDVNTGKTDLGVLYGKPQSVVSKEKTFMEVFRGLAGNENNDVEDKVLVDELVKTGKFSDEEAKKFIQKFNREGQIFERRPGFWAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFW9</accession>
    <name>K0IFW9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c07660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07660"/>
    <dbReference type="EnsemblBacteria" id="AFU57708">
        <property type="protein sequence ID" value="AFU57708"/>
        <property type="gene ID" value="Ngar_c07660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07660"/>
    <dbReference type="HOGENOM" id="CLU_037146_0_0_2"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-764-MON"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="334" mass="37717" checksum="2D7C5EA4EB3EABAF" modified="2012-11-28" version="1">MTIRIDEKRIFEIIEQRKPRSVALNGPEGLMSKLQDAADHITEKFGIEAYVIGDTCWGSCDLNTHAADMLGADILFNIGHTIAMETFGEKLIMIGAFDDISFDSVATKCAKGLQGKYKTVSLLTDSQHLHQIESVKKIFEDHGYNVIIGRGKGQLRDAQVFGCEFYPAYNIQKQVDAYIFLGQSVFHSASVAMSTEKPTFMLDPYFEEYSQVNEFAQGMQKRMILSIYKALDAEKIGIIIGLKEGQFAHVRALELKKEFEKLGKKVQMIALTEITDDRIQVFKGIDAFVQVACPRIATDNHFKKPMLSVPQAQALLKLLRKEPIEDFLKVQHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFY2</accession>
    <name>K0IFY2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60306">
        <property type="protein sequence ID" value="AFU60306"/>
        <property type="gene ID" value="Ngar_c33910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33910"/>
    <dbReference type="HOGENOM" id="CLU_3282986_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3392-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="40" mass="4368" checksum="4B133002D6E2A24A" modified="2012-11-28" version="1">MLQLPAKQQQKTSKNSGAFAHLVLSIGVGPLDIFKIIVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFZ2</accession>
    <name>K0IFZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60321">
        <property type="protein sequence ID" value="AFU60321"/>
        <property type="gene ID" value="Ngar_c34060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34060"/>
    <dbReference type="HOGENOM" id="CLU_1197664_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3407-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="23882" checksum="D55DD2FA46A941DF" modified="2012-11-28" version="1">MFGTLLSFLPAIQILERFDDDNNSMMAIPTASAQFIIPEEDDSGNQNTSTSTSSSTQNITSSSPPSSSSLLLRGLIGSMIIASSSTTTNQNANGTTDITDDYIVVGRWRMLVNESLVQRFAANLTVARVDGSEYHNNIIIESIGRPSEFAGNASNIMTQISTDSSVPGEVIPLRLEIKDRVLEIADINIDENTVEDQELGNILSIIDGQSIFGIVEFQGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG54</accession>
    <name>K0IG54_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60386">
        <property type="protein sequence ID" value="AFU60386"/>
        <property type="gene ID" value="Ngar_c34710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34710"/>
    <dbReference type="HOGENOM" id="CLU_2461870_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3472-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10039" checksum="5296B5B723624D8B" modified="2012-11-28" version="1">MTLEQTVPLISEGLEPFNDFTLEIDLEIYADAWSNVYDWHEGVDIREDIELGETVSIPWQKRLPIAKGIPDLGILFDGEEIDTFGNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM8</accession>
    <name>K0IGM8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 4-oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00120"/>
    <dbReference type="EnsemblBacteria" id="AFU56962">
        <property type="protein sequence ID" value="AFU56962"/>
        <property type="gene ID" value="Ngar_c00120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00120"/>
    <dbReference type="HOGENOM" id="CLU_148073_5_3_2"/>
    <dbReference type="OMA" id="KENWFLA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-12-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5904" checksum="C6921E810E3D48DA" modified="2012-11-28" version="1">MYPGRTKEQKDEFAKAITDAAVQILKTKPEHVIVVYDEKPKENWFQSGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGU4</accession>
    <name>K0IGU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58063">
        <property type="protein sequence ID" value="AFU58063"/>
        <property type="gene ID" value="Ngar_c11210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11210"/>
    <dbReference type="HOGENOM" id="CLU_1369567_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1119-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="23330" checksum="6DD66A1D3394F5B4" modified="2012-11-28" version="1">MKENRSVPITFRIYADSLQILKEHADREDLSSNTLLNKILKRWISFELSIQPLNPIILPSNLFAGLLDTVSDEDWEILKQQLIPEVVKSLFSLIYDTSRPEELFKHLEFMSKYSGWFSLQVFKNNGITNIVKLILKHNHGIKWSLFLKEYLQDIIKTYYRNLPISFESNEEYVLFTVRATEQLSLSKLSYSSDNSRSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW7</accession>
    <name>K0IGW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ferritin Dps family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59100">
        <property type="protein sequence ID" value="AFU59100"/>
        <property type="gene ID" value="Ngar_c21700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21700"/>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2168-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="19050" checksum="E80B3795EF97B3AC" modified="2012-11-28" version="1">MGKKSLEIAGPGADGTVAMLHKAYAFEMSTFHYFQYVANNIEGIGVLFEDFFEERAKEELGHAEEVNERLMELGTNPTDDPARWEQENGVGRLQPKRFLSLRSAIEKALEFERVAIGLYNDLANATKDKDHGTYELALKLLKDELEDEQTMEDILARLEIKDVPAAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH48</accession>
    <name>K0IH48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase, M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12130"/>
    <dbReference type="EnsemblBacteria" id="AFU58153">
        <property type="protein sequence ID" value="AFU58153"/>
        <property type="gene ID" value="Ngar_c12130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12130"/>
    <dbReference type="HOGENOM" id="CLU_1192653_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1211-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="115"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="232" mass="25655" checksum="946102D9FD9D2AEE" modified="2012-11-28" version="1">MYSAFTSLPASLALFSAVLAPAFILSPIFSAPFSMSDVIARRPRNIIYSTLGSLTANQILLQETENSLWQGRPLYQYACAKYGVQAINRYLLPVPKDALRKIDRTTSPAHIGKLKNAIDFIVDTGTPVLAAADGIVTFVRDDSYTGGPSIEYWQDSNFIVIQHANGEYSRYDHLAHKSAKVWIGQLVGAGDIIARVGMTGFTYVPHLHFQVFVFTGSNIWVNFETLSVNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH88</accession>
    <name>K0IH88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59265">
        <property type="protein sequence ID" value="AFU59265"/>
        <property type="gene ID" value="Ngar_c23390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23390"/>
    <dbReference type="HOGENOM" id="CLU_3003266_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2337-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6752" checksum="7CD37B51A78E24C2" modified="2012-11-28" version="1">MQDNWQKIPRGRWLKCTYEKCGHEWQYFGGRKWAECPACHSIVKVAVAQRNYYRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH98</accession>
    <name>K0IH98_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheS</name>
        <name evidence="9" type="ordered locus">Ngar_c23550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23550"/>
    <dbReference type="EnsemblBacteria" id="AFU59280">
        <property type="protein sequence ID" value="AFU59280"/>
        <property type="gene ID" value="Ngar_c23550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2330"/>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_2"/>
    <dbReference type="OMA" id="VHIKHPV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="244"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="494" mass="55411" checksum="755F4DDFE9452B9E" modified="2012-11-28" version="1">MSSAPTLHPIERSILKALANNDSDAGSLAASTGLSIDQVRRGIEWLKFKNLISISESSILKVQLGSEGAAAIANGLPERRLVNAVKQGKATIGEILTSGTVKNEEVNAAIAGARRNQWIQFVEGRMEATALAEKQSAEETFLANLKNGTAAEVGKMTESEKKILEQLKKRPNYVEIKEEKESRISLTGAGRALIPTLDEGQGERRLTSEMITSGRWKQTKFSALDVEAPAPAVYPGRRHPLIDIIEEVKEIFVGLGFSEIDGPMVQSGFWNFDALFTPQDHPAREMQDTFYISGQRQHIPASDEQKKRIAKVHEKGWGSKWDIKEAERVVLRTHTTPVTLRHLATIKPEVGRYFSVGRVFRNEKVSYKHLVEFHQVEGVATAPRASLRDLMGLQKEFYAKMGIKKVKFWPTFFPYTEPSLQSMVYNERLEKWVELFGMGIFRPEVTEPLGIKNPVLAWGGGLERIAMLRFGLDDVRELYGNRLAWLRSVPRCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA2</accession>
    <name>K0IHA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FUN14 superfamily-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c13150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13150"/>
    <dbReference type="EnsemblBacteria" id="AFU58253">
        <property type="protein sequence ID" value="AFU58253"/>
        <property type="gene ID" value="Ngar_c13150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13150"/>
    <dbReference type="HOGENOM" id="CLU_095425_1_0_2"/>
    <dbReference type="OMA" id="FWLQQKG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1313-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="PTHR21346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="11301" checksum="CAEC1696B4CCFD5F" modified="2012-11-28" version="1">MSVDLAFTGTSVGFGGIAGFLIGYAIKKAIKIMMIIVGLFFAALAYLNYQGIVTINWDKLSASASGVTSGLGNATGQIAGVSDQIAPTLINFGIPLTGSFAAAFVLGFMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF2</accession>
    <name>K0IHF2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stomatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02640"/>
    <dbReference type="EnsemblBacteria" id="AFU57212">
        <property type="protein sequence ID" value="AFU57212"/>
        <property type="gene ID" value="Ngar_c02640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02640"/>
    <dbReference type="HOGENOM" id="CLU_2299426_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-264-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="10853" checksum="59B8AF916FCD6438" modified="2012-11-28" version="1">MRKMSSSLFSISKRIVNQKGSGAHAIAGLLILIVGVAFGLSIESEALVYAAIVIGLATIISAFLMIIKQYERVIILRLGRYHRQVGPGVQTRIPFVDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHK9</accession>
    <name>K0IHK9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03140</name>
        <name evidence="3" type="ordered locus">Ngar_c03440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Enrichment culture Ga9.2</strain>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57262">
        <property type="protein sequence ID" value="AFU57262"/>
        <property type="gene ID" value="Ngar_c03140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57292">
        <property type="protein sequence ID" value="AFU57292"/>
        <property type="gene ID" value="Ngar_c03440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03140"/>
    <dbReference type="KEGG" id="nga:Ngar_c03440"/>
    <dbReference type="HOGENOM" id="CLU_537058_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-314-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="519" mass="59372" checksum="011F066DF0D0A6E7" modified="2012-11-28" version="1">MATVTVSTPPAAMPAPTQTEIDAVSATSMETTSTPQRAITSQKKVKKVRTGGRLDGVRRNYRSVGGKTFDDTNAVKEHILQLIETKPRTPRELCKLTGYSRMNINRYTSKLAKEGKIEKDGHMWKKKNLTAAQVAQVLVENLSEEEFGQLPILKPWIEKLGDNPSRGERREFSCFRNICLGIYLPGFKCNPENWQYKETTREFAEKYKAATGRKKPPYGVRQSIRTFLGVCLGIPLRENPFLIQIGIDGEKENIGAHGDIKISEEDGELDKAIEYCKSLPEPLNLQMLALLAFNMEAMPRSERGMLIEVEDVSFEDQVIEQAWLKNYAKPVRDPDQLQMLHALALALPDGVVRFERVTRRIAVVKHLETKTGDEWETYIITPALVQAAETWIEQRRNAPGVSWIDSEGNRHEGYRYVFYDGHDINPDETQEGGILEQVNAQYNFRENLRALYRHLGKTDAYMFKQPLYTLRHCGAQLMLERSDYDYDYVAEHGWNDTATLRTWYGHRGKASLKDKLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHM1</accession>
    <name>K0IHM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14770"/>
    <dbReference type="EnsemblBacteria" id="AFU58413">
        <property type="protein sequence ID" value="AFU58413"/>
        <property type="gene ID" value="Ngar_c14770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14770"/>
    <dbReference type="HOGENOM" id="CLU_596687_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1475-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="418" mass="46986" checksum="58DECECAC7351F88" modified="2012-11-28" version="1">MVGNAATGAEGWLPADDAILRIAQKEKLHGNNGIGYLSKRPPPFPSMNNIWVAFDGFFVDTEKLHLHPYIGPARDSDSLFKIYHIFIQLLIQKKNPERAAEFLDRHLRGNLLVKVGDEIYAYRDSTGFKPLVTATNYDKTLNIIASENSLRTSLIDMQFSDVMPGQLLKMSKKSGLEVIASTSTIKMMMDPFEFIRESNVVATVNGKSVYQIRKNIGKEQANFLSKDLDIDSAYAEPDYTRPMTLGFGLEYQKHSKGFEIAEGIIKDRYDDSDHMIDFSEQVSKNKLLTTGRSLKFVMQNLVQGKKIATVQGTIQTGSTTRETIYYLKNAGAKCIDVVVSYVPTVDGRQVGLYTQNRDLIANKYVGEVSSINELNQKVAREIGSDTVYYNSPAVLAKGIGVPENNLWFPEWVRFLDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHM7</accession>
    <name>K0IHM7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58423">
        <property type="protein sequence ID" value="AFU58423"/>
        <property type="gene ID" value="Ngar_c14880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14880"/>
    <dbReference type="HOGENOM" id="CLU_1514665_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1486-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="177" mass="19341" checksum="54542485E8607793" modified="2012-11-28" version="1">MRVAVVAPSLFELKAACSVAISKLAATGHEVHAIVVSNTPVSFMSAKKEEEGPKETLLDNAGISQIHFVDGFDYSAITQANADKINAHIKVISPSAVIMPHWKSPSHNHMILARTTLIACRGVGSILMYEVNNNANFVPTIMFPAKRDFGIQTGDLDVAEERYESHRLLLLDEVEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHM9</accession>
    <name>K0IHM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58428">
        <property type="protein sequence ID" value="AFU58428"/>
        <property type="gene ID" value="Ngar_c14930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14930"/>
    <dbReference type="HOGENOM" id="CLU_2597864_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1491-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8976" checksum="B1835B288ED1E53A" modified="2012-11-28" version="1">MQGNIYHFELNENRDGLSLNGTLSDRIVDSPEELKPLVFVQGFNSSIIDMDIASDGYLYFTTYYRHDASIYRVVPKGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU3</accession>
    <name>K0IHU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58513">
        <property type="protein sequence ID" value="AFU58513"/>
        <property type="gene ID" value="Ngar_c15800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15800"/>
    <dbReference type="HOGENOM" id="CLU_2802396_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1578-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7695" checksum="10E16EB6D85B441A" modified="2012-11-28" version="1">MIDWQRFNRQSGSRRQSITGSLQRVKRFARNARLLFFLMQSMECAPYAGSNVSRKIGVIRGGMDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU7</accession>
    <name>K0IHU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58518">
        <property type="protein sequence ID" value="AFU58518"/>
        <property type="gene ID" value="Ngar_c15850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15850"/>
    <dbReference type="HOGENOM" id="CLU_2010159_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1583-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="12688" checksum="81597C318128FDF4" modified="2012-11-28" version="1">MPTRKESTRIVAYTAAGIIGEIALAGFIISGGVLPDANVSQTIPPGLEPGFLHGYVDGPGGLPAIGATVLAVQQGTDFAASAFVFVNGQYFIDVPPGTYIVYVAYPDGTDKIATVEEEDQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0II48</accession>
    <name>K0II48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07090"/>
    <dbReference type="EnsemblBacteria" id="AFU57652">
        <property type="protein sequence ID" value="AFU57652"/>
        <property type="gene ID" value="Ngar_c07090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07090"/>
    <dbReference type="HOGENOM" id="CLU_050006_5_0_2"/>
    <dbReference type="OMA" id="LDIHHLD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-707-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="280" mass="31586" checksum="28BA2023B5CC58D3" modified="2012-11-28" version="1">MKLAFSTNAFKKYSLQDSIKEIAKIGYKGVEILCDVPHAYPPDFGDDKAWQLKDVISSHGMQISNLNAFTLYAIVGGGDVYHPSWIEQDEHSRQVRVQHTIDCVQLAKKLGAKNLSTEPGGPIPSNRDSNKLEKVFLETLVPASKAAEEEGIKLLIEPEPGLLIENSSQFKRFIKNVNSDYVKLNFDISHFYCVNEDPAKLVYELVDYIEHFHLADIENRVHNHLIPGRGEIDFHSVFAAMEDIGYEGFVTVELYPYQDSPVQAAQEAYSHLCSIIESIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB9</accession>
    <name>K0IIB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-splicing endonuclease</fullName>
            <ecNumber evidence="3">3.1.27.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">endA1</name>
        <name evidence="3" type="ordered locus">Ngar_c17700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.27.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17700"/>
    <dbReference type="EnsemblBacteria" id="AFU58703">
        <property type="protein sequence ID" value="AFU58703"/>
        <property type="gene ID" value="Ngar_c17700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17700"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1746"/>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OMA" id="KGPGIDH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="1">
        <location>
            <begin position="88"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="181" mass="20446" checksum="7FE333AC23E7A2F5" modified="2012-11-28" version="1">MISGKLVESRIVIWDIPDSRTLFGSGYYGKPLGIPKPKGTDFDAPLVLDLIEGCYLVEKNKLKVTHINGKAVPLAEIKKICKKQYVDFETQYFVFQDLRDKGYIVTPGIKFGCDFAVYEQGPGIDHAPYLVQVFRPADDLTATEVVLAGRLATTVKKQFILAIPKIKERKVDYVGFDWWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM1</accession>
    <name>K0IIM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57937">
        <property type="protein sequence ID" value="AFU57937"/>
        <property type="gene ID" value="Ngar_c09950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09950"/>
    <dbReference type="HOGENOM" id="CLU_2392986_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-993-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10515" checksum="B18A3F11253A0358" modified="2012-11-28" version="1">MLREPPGAKDRANIETALKTYSGMISSTPQMRQGLSGIMMPGGKEMAEMVEFAEKYKAIYTPERAKSPKKFKTLDIQSMLKSERQSLCRQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT5</accession>
    <name>K0IIT5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58988">
        <property type="protein sequence ID" value="AFU58988"/>
        <property type="gene ID" value="Ngar_c20560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20560"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2054-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="16953" checksum="2444514D7F368807" modified="2012-11-28" version="1">MVRESSIQKILVGVDGSPSSDKAVEDAINLAKMTSAELVFVHVIEDIKMGGVIGARARYGDVKLVEGYNRARKESALQWMKRYEEQASKANLEARREILYDTGKSVTGMIVEYAEKNAVDLIVVGTRGLSSFKRLLLGSVASGVSNHAPCPVLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW8</accession>
    <name>K0IIW8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58072">
        <property type="protein sequence ID" value="AFU58072"/>
        <property type="gene ID" value="Ngar_c11300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11300"/>
    <dbReference type="HOGENOM" id="CLU_1302661_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1128-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="25787" checksum="83B15C4CBA7C208B" modified="2012-11-28" version="1">MKKSRLRIKGIKVKDKDKIKEAIMISIQKGNYTTREIGLDIGKDYTTVSRYLSEIENDPKWGLKRDLNGNIVMSLQEQLAHEYARLQNEKYSQLPSIQKWITYLKSGKTPATRIRYMINIIHGISDQLMVMPETLVSHGVPIDSAKRKEIAIEYWQNFLAWFNTACPQMQRTNTIVAYRSFLSAHSINFAHGEGKRYGLSTTSERLGEYKDIICLRRNKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ60</accession>
    <name>K0IJ60_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58237">
        <property type="protein sequence ID" value="AFU58237"/>
        <property type="gene ID" value="Ngar_c12990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12990"/>
    <dbReference type="HOGENOM" id="CLU_2056127_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1297-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13326" checksum="1EFAF1CB30DEF5C7" modified="2012-11-28" version="1">MSEGIANRIHHLVEAMNRLELQIANETEVLKDHYVKAAAAMPEGKNYFLNGVQTGSVVKSYLLTRRGVEVPGEGIIQIPEFIDNVLRFANYPKRKIEVLNDLATHLQNVYALVGSQEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ68</accession>
    <name>K0IJ68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mercuric reductase, MerA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22180"/>
    <dbReference type="EnsemblBacteria" id="AFU59148">
        <property type="protein sequence ID" value="AFU59148"/>
        <property type="gene ID" value="Ngar_c22180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22180"/>
    <dbReference type="HOGENOM" id="CLU_2565858_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2216-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="8397" checksum="2B628D89C128329E" modified="2012-11-28" version="1">MENAGIKTRKDGVVIVNSEMRTSAEHIWAGGDVVGEPMLETLAAKAGATAAENALVGSHKKTGLLTVPSAIFTSPRLPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ76</accession>
    <name>K0IJ76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c13440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13440"/>
    <dbReference type="EnsemblBacteria" id="AFU58282">
        <property type="protein sequence ID" value="AFU58282"/>
        <property type="gene ID" value="Ngar_c13440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13440"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="HVSGDYD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1342-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14625" checksum="5DA4455DA43CB924" modified="2012-11-28" version="1">MSYRKVAEDIGVSPPTVLARVSKMEKEGIIKSYSALLDHEKLGYDLTAIIDITATKGKIVDLERQIAKFPNVCAVYDITGLTDMTIIAKFKNRAELSNFVKKDLSLPYVERTNTHVVLVTVKEDFRFVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ8</accession>
    <name>K0IJJ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c24440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24440"/>
    <dbReference type="EnsemblBacteria" id="AFU59368">
        <property type="protein sequence ID" value="AFU59368"/>
        <property type="gene ID" value="Ngar_c24440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24440"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2418"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="VEEIHTV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2442-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16957" checksum="6D224DF7CF328F9D" modified="2012-11-28" version="1">MRILSELTRDASISVPRLSKKLNVNASVLYSRIKRLTKRSLVKKFTVVVNENMLGINVKATVGINRDPKLKEPIHSELMKIPEVRSLSEVTGRFDMIVSVSAHTLEELHNVVIERIGKIEGIQNTETFVEMQRTEKEPLYTVQQSSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJP0</accession>
    <name>K0IJP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60275">
        <property type="protein sequence ID" value="AFU60275"/>
        <property type="gene ID" value="Ngar_c33600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33600"/>
    <dbReference type="HOGENOM" id="CLU_116583_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3360-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="22671" checksum="E1594591A3446EA4" modified="2012-11-28" version="1">MVGERGAKPLLIHTFYKSKRAICSKGVKQRLIIKLLASQKSYYYPSSKPDITRGVLAKYLSDKLGISAVNAYHYVFKELDECLVPNGFVEEHGAVATGKGPGLLQKTGIPCYRLTLLGMLVASTLEDEFDLQKRIELVRHYLKSKKVLDTNEFSSIEELLLRLQRYPQKTLELIRYSVMEYINGKTRNPLDSIKRQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX0</accession>
    <name>K0IJX0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative prephenate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16340"/>
    <dbReference type="EnsemblBacteria" id="AFU58567">
        <property type="protein sequence ID" value="AFU58567"/>
        <property type="gene ID" value="Ngar_c16340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16340"/>
    <dbReference type="HOGENOM" id="CLU_036672_1_1_2"/>
    <dbReference type="OMA" id="IVAVPFW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1632-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="289" mass="32195" checksum="9DCF9AB0C91705CC" modified="2012-11-28" version="1">MPKLQEIAIVGAAGKMGSWFTNYFARRGLHVSVYDVNKETLRPSGNVRVASGISACVKGADLVLVSVPVRMTPQIIRECAKSMKNDGAIISEISSVKHRTFQALRRVPGHLRPLCIHPMFGPGASDKMQTKVLLVPVRNEEAELKIVHEMFENAAVKVLPDARTHDKAIATVLGLTYFANIVFAKVVSGNNISMLKQVSGTTFGLQSLIAESILTNEPDLVIALIQENPYAKKYIQQYLKKAAVVAKMASARDSKRLRADLKKVRSKMQKWQDLQQSYRRMYDIIENMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ9</accession>
    <name>K0IJZ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58607">
        <property type="protein sequence ID" value="AFU58607"/>
        <property type="gene ID" value="Ngar_c16740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16740"/>
    <dbReference type="HOGENOM" id="CLU_2748321_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1672-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7766" checksum="94AB47A5EF8D92A1" modified="2012-11-28" version="1">MALGEKAFEESGNVVGFKVTKVHPIEGTTMEVSFAYVTLRAPSQDSQVAKMLWLCGTMTHNIYPHIHMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK00</accession>
    <name>K0IK00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59553">
        <property type="protein sequence ID" value="AFU59553"/>
        <property type="gene ID" value="Ngar_c26310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26310"/>
    <dbReference type="HOGENOM" id="CLU_2550385_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2631-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9033" checksum="5511A66AEBB4A924" modified="2012-11-28" version="1">MYGLAASVMSYIASLSYDDSLMDRVTSAANFPAILTLFYVEWNMANPNGFSMLFHSAIIIAGSIVVWSFIGLLIYLFIKLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK21</accession>
    <name>K0IK21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58637">
        <property type="protein sequence ID" value="AFU58637"/>
        <property type="gene ID" value="Ngar_c17040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17040"/>
    <dbReference type="HOGENOM" id="CLU_2730543_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1702-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7912" checksum="A3057DAB55199BCD" modified="2012-11-28" version="1">MSIDGLWFKSETVIFQATKGSPSLRSTVPQDVVDFLQLQPGDVLEWLANIKDNKVTVIVRKKKPADKLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK34</accession>
    <name>K0IK34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
            <ecNumber evidence="2">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35820"/>
    <dbReference type="EnsemblBacteria" id="AFU60495">
        <property type="protein sequence ID" value="AFU60495"/>
        <property type="gene ID" value="Ngar_c35820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35820"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3589"/>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_2"/>
    <dbReference type="OMA" id="VISLCGC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3583-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14597" checksum="E528101E35CF02AB" modified="2012-11-28" version="1">MKVVLFVCVENAGRSQMAEGFFNKHAPPGYRAVSAGTKPAGQINPLAVQAMKEVGIDISGQKSKIITDDMIRDSVRAVNMGCMDRSDCPLLFLNNPVDWNIEDPKGKPIEKVREIRDEIERRVKELAENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK41</accession>
    <name>K0IK41_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59593">
        <property type="protein sequence ID" value="AFU59593"/>
        <property type="gene ID" value="Ngar_c26720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26720"/>
    <dbReference type="HOGENOM" id="CLU_1682758_0_0_2"/>
    <dbReference type="OMA" id="IEVAYAN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2672-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="16714" checksum="196F44BE6C1CA252" modified="2012-11-28" version="1">MRQRTLVIAGLAAVGVAIAVAVPMAILAMQESHELKFEYVKSGGIAGINEKLVFDSKTGVITFYRSTLGSTEERQLSDAKVQELRQAIAGSGFFAMDSVYPPRQGPADYFSYSLTITMDGVTHSVSWIDDFASSEPVPAGLKSIVSEIEVAYANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK94</accession>
    <name>K0IK94_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="5">5.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cobH</name>
        <name evidence="5" type="ordered locus">Ngar_c17990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="5.4.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17990"/>
    <dbReference type="EnsemblBacteria" id="AFU58732">
        <property type="protein sequence ID" value="AFU58732"/>
        <property type="gene ID" value="Ngar_c17990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1778"/>
    <dbReference type="HOGENOM" id="CLU_084703_1_1_2"/>
    <dbReference type="OMA" id="DLAWQAY"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="4">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="226" mass="24509" checksum="CF47B4876C7D7059" modified="2012-11-28" version="1">MASDHHHSGTAAGRAMSNRAFDIEKKSFEIIDSEIGSHDYNELQWAIVRRVIHATADFDFAGKGKILFHERAIESAFDAIRNRCTIVTDVDMVLAAMNKKSLTDLGLRTACYISDSGIAEEARRSGRTRSEVAMRHAAKDMDGGIVVIGNAPTALYEVISMVREGVTKPALVVGIPVGFVSAPESKEELAKMDDVPFITNVGRKGGSPAASSIINAMLLLYQSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM1</accession>
    <name>K0IKM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c21060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21060"/>
    <dbReference type="EnsemblBacteria" id="AFU59037">
        <property type="protein sequence ID" value="AFU59037"/>
        <property type="gene ID" value="Ngar_c21060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2087"/>
    <dbReference type="HOGENOM" id="CLU_023194_10_2_2"/>
    <dbReference type="OMA" id="GWHHARV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2104-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="315" mass="34585" checksum="190C64751E8ED814" modified="2012-11-28" version="1">MADTTKIAVIGVGGWGKNHARVLKDLGCLAAICDLDAARAKEIAGKHGAQAYSSIDEMLSKERLDGCLVCTPTKTHAAIAKKMMEHNINTFVEKPMSFSSKECEEMMQMAEKKKVVLTSGYVERFNPAVSDARKLIEGGMYGDPMMIEFHRENRMPLHIKDVGVIYDTSVHDIDAAMFLFGSRPNVVFARAGKRFHAFEDFATIMLGFDGHKVAIIASNWLTPKKVRTFSAVCTDGIITGDFLTQEIRIDHAEATITPRRQFQEPLTLELQNFVAAIEGKAKIVVTAADATNVTRVAEAAILSSNTGSPVYLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL22</accession>
    <name>K0IL22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59272">
        <property type="protein sequence ID" value="AFU59272"/>
        <property type="gene ID" value="Ngar_c23470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23470"/>
    <dbReference type="HOGENOM" id="CLU_112936_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2345-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="17802" checksum="5E1A7189AA513037" modified="2012-11-28" version="1">MRTFRHTFTVNAGIDKVWDFYTDINHLQVISPPGMQIRLVKTTHQKLIEGSEVWLTGILLTRSSWHSKITSLAPYRYVDEMLSGRFHVWKHVHGFRKVDGNNNTATEVIDEIDFELHYGMLGRIFEGYVYSQLEKIFAYRKQATIKALEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL63</accession>
    <name>K0IL63_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60168">
        <property type="protein sequence ID" value="AFU60168"/>
        <property type="gene ID" value="Ngar_c32530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32530"/>
    <dbReference type="HOGENOM" id="CLU_2581543_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3253-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8588" checksum="BFE912DDE67E1D2D" modified="2012-11-28" version="1">MSSSWLYIAFGISAALLIIGAFAIITAQAELASGKRTVTMVGKVAACRTKSHGLVYLAVVQKRRNAALDSWEKMESIIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA2</accession>
    <name>K0ILA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60273">
        <property type="protein sequence ID" value="AFU60273"/>
        <property type="gene ID" value="Ngar_c33580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33580"/>
    <dbReference type="HOGENOM" id="CLU_116583_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3358-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="22272" checksum="50838C7C8B5BE48C" modified="2012-11-28" version="1">MLVDDTDLAKKKICLFPRATQSTSVPNRGIYQRLIIASLALHVSSMTRSALAKVIAKKLGITWKNAYNHIMNELNSCLIPSGIVIENGNIPSIRGPRIYQMTGIPCYSLSDIGILVACSLEELDIEVRKSLLQQLLNNNRQRTKVGGRSFIDARQREELVAHLQSYPQFTLELIKSGVIKFLEGKIHHPLDIIPKSNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB8</accession>
    <name>K0ILB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stomatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c33880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33880"/>
    <dbReference type="EnsemblBacteria" id="AFU60303">
        <property type="protein sequence ID" value="AFU60303"/>
        <property type="gene ID" value="Ngar_c33880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3382"/>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_2"/>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3389-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="309" mass="34436" checksum="2A2A96887A14DE36" modified="2012-11-28" version="1">MSLLLQLAFGELVGAGIAIIIMVVILVSAIRIVREYERAIVFRLGRLIGAKGPGLVFLVPIVDKAVKVDLRVVTLNVPKQKIITLDNVTVDVDAVVYLRVNEPNNAIIRVNDYLLASSLLAQTTLRDLIGQVTFDDILSKREELNKRMQEVLDAATDPWGVKVTSVAIRDVSLPENMHRAIAKQAEAEREKRGRIIIAEGELKAAEKMSQAANFYTQNMAAMRLRELQTWTEIARERNMVVVTGARDSEDLSTLFGILKQRLPGQQPTTEQWSSEEDVRRMIRQELARLARGEAGTEDKGGRREEIAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC4</accession>
    <name>K0ILC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56999">
        <property type="protein sequence ID" value="AFU56999"/>
        <property type="gene ID" value="Ngar_c00490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00490"/>
    <dbReference type="HOGENOM" id="CLU_2875195_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-49-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7186" checksum="146D5D12DB6D5F00" modified="2012-11-28" version="1">MPLHFLAKAPYSWIMLAIVPWSCEPDSCPALWTMSKEFGITFILKHSFTVVAAQLYHTIFKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE4</accession>
    <name>K0ILE4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34430"/>
    <dbReference type="EnsemblBacteria" id="AFU60358">
        <property type="protein sequence ID" value="AFU60358"/>
        <property type="gene ID" value="Ngar_c34430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3441"/>
    <dbReference type="HOGENOM" id="CLU_2379514_0_0_2"/>
    <dbReference type="OMA" id="MAAKING"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3444-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11234" checksum="13F27C91C17C7BBB" modified="2012-11-28" version="1">MMRKDDDENEIPVTVFVKSASGSEIASKLAGYFVIKGQEFRFTAIAFGRIGGHNASVKIAKTTLDKIAKMGIDPEQLQLTIQRKLIEGDIILPEGIKPPSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF0</accession>
    <name>K0ILF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pre-mRNA processing ribonucleoprotein, snoRNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c34580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34580"/>
    <dbReference type="EnsemblBacteria" id="AFU60373">
        <property type="protein sequence ID" value="AFU60373"/>
        <property type="gene ID" value="Ngar_c34580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3457"/>
    <dbReference type="HOGENOM" id="CLU_015495_1_0_2"/>
    <dbReference type="OMA" id="REWYSLH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3459-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="259"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="432" mass="48018" checksum="119F899500E484ED" modified="2012-11-28" version="1">MANNPCSVVLLELGVAAFDQSGGLVASKKFDNAIRSYRLLKSGATPDEIRSFIEKLRSFDPVTTNDASVAAALRQAGLNSQSMPEDQQQWIQSSKPSFLVKAGFVNNEQDAMQALREFAINLSSSRVKEASERLDLHIIQSINALDELDKVINTVGARMREWYGLHFPELDNLVQSLVAYAEIVSRAGLRENITAEILQSAGMQGKKVEIILDGARRSKGGDMTPENLAIVKRLADQVIAQSDLRRVLADHIEVAMDTVAPNVKELLTASVGARIIAKAGSLARLATLPASTIQVLGAEKALFRALKTGARPPKHGILFQHPLIHSAPKWQRGKIARAVASKVAIAARIDYYRHAGKDSSIQDRLNTRLTEIREKYKEPIPEKERERKYREHAQRQQEYGGGGGRGRGDGDRDKRDVRKKKDRRKRFGKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILS2</accession>
    <name>K0ILS2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">asnB2</name>
        <name evidence="7" type="ordered locus">Ngar_c27210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27210"/>
    <dbReference type="EnsemblBacteria" id="AFU59642">
        <property type="protein sequence ID" value="AFU59642"/>
        <property type="gene ID" value="Ngar_c27210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2700"/>
    <dbReference type="HOGENOM" id="CLU_014658_4_0_2"/>
    <dbReference type="OMA" id="DWSGIYS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="4">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="557" mass="61696" checksum="2CD7681D84EF7F05" modified="2012-11-28" version="1">MCGIAGIVSKNGENVVPLVGSMLLCMINRGPDGAGLVADGHIIKSNSIATMRPQFQKMSGKSALGHTRLAIVGGTCGAQPFSSCDGRLVLEHNGEIYNYKKIRKKLEKRHKFSTTTDSEVIVHLLEDHLRRNSLIGAIKRTVAELDGVYALAIQDIKTGKTALVRDRIGVRQLYYADNGRFVAFASERKALWRIGMSEPTRSILPGSATVVSSDGQLESFHVADPIPPKVRIVHRTMKSAVEGYRKALIESMEKRTQDFQRIGIIFSGGIDSVLVAYLAAKMVPEVVCYTGGVKGSHDIAYARQIAERLDLKLKVAELDQDAVEKLVPEVINVIEDANAGQVEVALPVYSAVKLAHEDDIRVMLTGQGADELFGGYSWYPKVVEKEGYKKLRERMVEDLLLLYKETLEREDKITMAHSIELREPFLDTEVIRVALATELRLNVKGGHDTFGKHVHRRLAQSLGIPKDIAYRVKEAAQHGSGMHDVIGAIARKHGFDDSSVPASYIAALRQREKIGSSQRYGYLFGDEKIWTAEPHVQMYLDSISKRLPQFEVVAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILS3</accession>
    <name>K0ILS3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57284">
        <property type="protein sequence ID" value="AFU57284"/>
        <property type="gene ID" value="Ngar_c03360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03360"/>
    <dbReference type="HOGENOM" id="CLU_1559539_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-336-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="17220" checksum="D757D96353B2DC38" modified="2012-11-28" version="1">MVGDTHAASLTGNDTHALGNDPSSAGGSSGTGNTINANVYDAWANTVENTAYILAAVTPGGATNLIYVCALVRGYKTANAGTITYRLKENTITLASVTSASLAVNTADSARAIEITLVNQSVAQHTYSITFQGSTSEVRSIFAGGCAKPVTLSGSDTHAASLTGGSGTCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX6</accession>
    <name>K0ILX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28520"/>
    <dbReference type="EnsemblBacteria" id="AFU59772">
        <property type="protein sequence ID" value="AFU59772"/>
        <property type="gene ID" value="Ngar_c28520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28520"/>
    <dbReference type="HOGENOM" id="CLU_553930_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2852-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="492" mass="54690" checksum="1F1C731CFA65C33A" modified="2012-11-28" version="1">MKLKGFLAMLFLSFLSSSTVIAAAPEQGTTTTAYRKFVVYYGWYTDGRGQIGPEIERIIAAKPEFVISPYYTSTGQVNLTPQVMDRFHENGIKVLVYVATGNADKKLESVLQEIKIGLDNGADGVMLDEVAMLHSDWQVDYYKRIYDYTKSFGSEKVVIANPGSVLVNEKVMSVSDIVSFEHQWRFASHIDWFSKYPATRFMGISSNDITNVMGYTVDSESSARDTIEAWQAGVSYHFSTNTYTTLAPWFEEYQKALEDYAVSGSKLGELRVRTIDSEGGEINGLWIEVRKNDRVVMTGFSPTRFLLPEGEYQVGAGNYQSFIFDRWQDGETSPYHSTTLADSSTAELVAVYRSELANLRVESYDNLGNSIREMRVTVSGSDGGVVAEGVTPLNLRLTLGQYSVVASDSEHYQFARWDDGSQVRTTSLAGDAKITAYYDNMLADKLGAEIFSCPPKYQQQVADSMLKSGPFAGLLELQMRKSAMALAGCPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM41</accession>
    <name>K0IM41_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c30610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59977">
        <property type="protein sequence ID" value="AFU59977"/>
        <property type="gene ID" value="Ngar_c30610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30610"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3061-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16314" checksum="993818A087E7202E" modified="2012-11-28" version="1">MARGRFASKKVIDFAEKDFVTLDENTLIAEAAKAMYERDVCSIIVTRNDRASNTRRAVGIITARDMLHRVIALNKSPFKTVLSRIMSTPLVTIDRDSSIEDAISLMRSKKITRLPVINEAGDLLAVASLKSLVRIAPSQKEAQDAIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM49</accession>
    <name>K0IM49_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60002">
        <property type="protein sequence ID" value="AFU60002"/>
        <property type="gene ID" value="Ngar_c30860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30860"/>
    <dbReference type="HOGENOM" id="CLU_1745473_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3086-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="15576" checksum="5CBC32922674E092" modified="2012-11-28" version="1">MLAGKMFYAAIAAGIAFIAIGAASSIYSGTVIDVPLDGTVRPGAQDIITPDMNVGNTASFTVSGSMYNITIREPDGQVIRSEGNARSGSYDLTASKAGEYRIEIVNVGDTDLTITGHAQTKSNPLGLSGALMLVITGVIVIGLGLRFRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM81</accession>
    <name>K0IM81_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60082">
        <property type="protein sequence ID" value="AFU60082"/>
        <property type="gene ID" value="Ngar_c31660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31660"/>
    <dbReference type="HOGENOM" id="CLU_2857218_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3166-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7022" checksum="60177461BC103657" modified="2012-11-28" version="1">MSSRQVWKKCTFCNNGRRTCFNCGGSGKVSPGWQTCYDCKGFGTVMCAECGGNGGRRETIWSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM82</accession>
    <name>K0IM82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31710"/>
    <dbReference type="EnsemblBacteria" id="AFU60087">
        <property type="protein sequence ID" value="AFU60087"/>
        <property type="gene ID" value="Ngar_c31710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3152"/>
    <dbReference type="HOGENOM" id="CLU_023205_4_0_2"/>
    <dbReference type="OMA" id="TWDLADH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3171-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="46"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="358" mass="41153" checksum="BE4FC39D6BBEB091" modified="2012-11-28" version="1">MKNGRVNILDVTCQLTTKLVRFMTQWIEKGCMEHYKLAPNLKICRILNGMWQAAGAHGRINPQAALEEMARYHRAGFTTWDLADIYGPAEDFIGDFMRSLPQQEQENVQALTKWVPEPQRITRQMAQSSIERSLRRMNMTSLDLVQFHWWDYNNPYYMDALKYLSDLHDEGKIRNVGLTNFDTERMQIMKDAGLKLVSNQVQYSIVDRRPEVKMAQFCRDNNASLLAYGTICGGLMSERYLGKPEPYDLDTASLKKYKRMIDAWGGWQLFQELLSTLHAIAQKHGVSIANVATRYILDKPAVAGVIIGARLGIANHRDDNARVFNFRMDKDDNSSIEDVCKKSNDLFEMIGDCGDEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM99</accession>
    <name>K0IM99_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hel308</name>
        <name evidence="4" type="ordered locus">Ngar_c07310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07310"/>
    <dbReference type="EnsemblBacteria" id="AFU57674">
        <property type="protein sequence ID" value="AFU57674"/>
        <property type="gene ID" value="Ngar_c07310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07310"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.706"/>
    <dbReference type="HOGENOM" id="CLU_006553_3_0_2"/>
    <dbReference type="OMA" id="MFLNANI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="242"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="724" mass="79557" checksum="A9A937665D016528" modified="2012-11-28" version="1">MLQVSAAITDGAVKALLSNLGYSSLYPPQKMALERGILEGKRMLVTTPTASGKTLIAMMAILKAVEKGTKAVYLTPLRALASEKYDDLKVLEQLDLGSGEKKKIRVAIATSDYDSSGKELAGADVIVLTNEKMDMLFRHNAEWLGDVGLFVSDEVHLIGDRERGPTLEMMLTKIRKHYPQSQVVALSATVANSDEIADWLGCELVESDWRPTKLVEGVYEYGAVRMGDGSRFKVTSSGVSSAVDLALDSLEGGGQALIFAETRKRAVSLAAKAVEGTYRRLDKAERELAASASSDIIAKGDDSETTKTLAQLVAKGVAFHHAGLGPSSRCIVEDSFKKGIIKILTATPTLAAGVNLPARRVVIASILRYDSDYGGSVPISVLEYKQLCGRAGRPKYDTSGEAIIVSESGVNAEELYDHYVLGSPEPLRSQLSSDSAVRFHLLSTIATVPGMKKPEIHELFASTLFARQYRSATVEFKVESALEYLEQEDLVKSKNDRYIATEFGRCTSLLYIDPVTAVAFRNALERVERREDGGKHKHTLGFLHLITSSPDFYPKLSLRKKDYDELSLLIQDRGSELLCSVSEYDCTRSFWALCEWMEETSDKVLGDKLGVEPGDMHRMVETGEWLAYSLYEMAKLLRREDLLAELYNLRTRIRYGVKEELLPLVALEGIGRVRARALYSAGLTDIGKIAKAPEAKLAGIPKIGPAVAEKLKDQLNKKKRLGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB1</accession>
    <name>K0IMB1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protease DO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32360"/>
    <dbReference type="EnsemblBacteria" id="AFU60152">
        <property type="protein sequence ID" value="AFU60152"/>
        <property type="gene ID" value="Ngar_c32360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32360"/>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_2"/>
    <dbReference type="OMA" id="THGWVLE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3236-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="311" mass="33171" checksum="CD9A1EE681CE3B1D" modified="2012-11-28" version="1">MIPVPEDVLVNAVEKAAKSVVNIASVRMLQDQLFRVFPVEGVGSGVVIDEKGYILTNNHVIDDAERLKVTLTDGRVLRGRVVGSDEVTDLAVIKVEAEQPLPAAELGNSDELKAGQIVMAIGNPFGLTGGPAVTAGIISSLNRSIQARSGVLELIQTDAAINPGNSGGPLVNTKGQVVAINTANMPYAQGIGFAVPINTAKSILKELIERGKVTRPWIGVSSMRVTPQLARYYGLPASEGALIAKVEPYSPADDAGLRRGDIIEGIDGDRVEDPSQIASHVRKKHVNDQLTLTINRYGRQLQIPIQVDERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD0</accession>
    <name>K0IMD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57799">
        <property type="protein sequence ID" value="AFU57799"/>
        <property type="gene ID" value="Ngar_c08570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08570"/>
    <dbReference type="HOGENOM" id="CLU_3075472_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-855-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6314" checksum="665D00085180CCC1" modified="2012-11-28" version="1">MGRVRRGNKSSEKRDHALHHATHRQFGEEPRPDHYHMRMKIQMIFTEKTESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI6</accession>
    <name>K0IMI6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC phosphate uptake transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="6" type="ordered locus">Ngar_c09820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09820"/>
    <dbReference type="EnsemblBacteria" id="AFU57924">
        <property type="protein sequence ID" value="AFU57924"/>
        <property type="gene ID" value="Ngar_c09820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09820"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.935"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="270" mass="30165" checksum="BD525D558F04A51C" modified="2012-11-28" version="1">MSEEETLAEREPLQTENLITPKVSIKNLNAWFGTKQALKNINMDIRENTATAIIGPSGCGKTTLIRCLNRMHEMTPGAAAKGHVILDDTDVYDKSVDPVVIKRRIGMVFQRPNPFPTMSIYDNVAAGLRLNGIRDRRLLDNIVQESLEHAALWEEVKNDLSKPGSSLSGGQQQRLCIARALAMQPEVLLMDEPTSALDPIASSKIEELIHGLKKDLTIVMVTHNMQQAARVADFTAFMYLGELIEYGRTKQIFENPQKELTERYISGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK5</accession>
    <name>K0IMK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c10270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57969">
        <property type="protein sequence ID" value="AFU57969"/>
        <property type="gene ID" value="Ngar_c10270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10270"/>
    <dbReference type="HOGENOM" id="CLU_032903_16_1_2"/>
    <dbReference type="OMA" id="WHADANA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1025-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="90"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="213"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="314" mass="35899" checksum="0DBA20FA4E3D22DE" modified="2012-11-28" version="1">MPGYLKDRDTKQTVVRGFYVRNDCYRLDRKHSTITIIGKNMKLRYATDRVREGKTGRLDVIYDRLKDAWYAFIPVDVVVAPAKQAVVSGKPEKVGSVDLRICNLVAFYAEGERPVVYSGRAVLSDYVYRTKKIAEMQSRLSEKQHTSRKMGLFYRTRTRRFKHATRAMLKDLFERMKQIGITKVAVGDLSGIRDGNNLGAHTNQKLHNFWSHAQTIQWIQHLCEDYGMDFAQVSERGTSKTCCVCGQGHNGRVHRGLHVCEENRVMMNADVCGAANIWNVAVKGELLPSTTRLPSSSRVMANPLVLRWDYAHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML9</accession>
    <name>K0IML9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58009">
        <property type="protein sequence ID" value="AFU58009"/>
        <property type="gene ID" value="Ngar_c10670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10670"/>
    <dbReference type="HOGENOM" id="CLU_2968568_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1065-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6618" checksum="D22D8BA7E2E10038" modified="2012-11-28" version="1">MVIWSPIPSAPELRCRICGIKKEKFDVQKDELTFDGFSNVKGTWYCDNGHLNSEGIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN7</accession>
    <name>K0IMN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c35290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35290"/>
    <dbReference type="EnsemblBacteria" id="AFU60442">
        <property type="protein sequence ID" value="AFU60442"/>
        <property type="gene ID" value="Ngar_c35290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3532"/>
    <dbReference type="HOGENOM" id="CLU_115707_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3530-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="23175" checksum="35BDE6303559A27F" modified="2012-11-28" version="1">MTTSSLRHEGPAARRTEKRKALWQIIVLAAALGVVLAATTFLLRPIFPDQYVLYFHAAEVAMAGFFVIQILSSISYNLTLAHSAQTAKSIKSLVRITGAIIIIAFIISYLSQDPVIAASISTISGLVIGFSSANIIGNVIAGMYLAIARPFRIDDRIKVFGEVGVVHDIGMLYTRLTLENGDEMLASNTSMVTSTVILKKRTEQSETTQKDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU0</accession>
    <name>K0IMU0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58209">
        <property type="protein sequence ID" value="AFU58209"/>
        <property type="gene ID" value="Ngar_c12690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12690"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1215"/>
    <dbReference type="HOGENOM" id="CLU_076204_1_0_2"/>
    <dbReference type="OMA" id="HCPYVKH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1267-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="20450" checksum="7B6587E5CC1EE2B5" modified="2012-11-28" version="1">MVKTESSPQVLRTGSRAPDFTLKGVDGKMHSLHDYKSRATLVVFICNHCPYVKARIGDIVALQSKFKPSELQVIGINSNDPNYKDEGFDNMVTFAKDHRLNFPYLIDDSQDIARAYGAVCTPDPFLFFDGKLAFHGRINDALDPEAKPTVPVMENNVRKLLKGERLEKDFDPSIGCSIKWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW5</accession>
    <name>K0IMW5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">16S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c13970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13970"/>
    <dbReference type="EnsemblBacteria" id="AFU58334">
        <property type="protein sequence ID" value="AFU58334"/>
        <property type="gene ID" value="Ngar_c13970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13970"/>
    <dbReference type="HOGENOM" id="CLU_035060_4_1_2"/>
    <dbReference type="OMA" id="DCSWESA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1395-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribo_biogen_C" evidence="8">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="18846" checksum="6764BDCC91ECD468" modified="2012-11-28" version="1">MKPLVYMLRQDDPFKCTAAKLAKFRLAEQVKFIRKNTIVLNPFSRTPVTKNDSATADSVCAIDCSWERADEVLKSQRLISQGIGRRLPAMLAANPTNYAKLGKLSSAEALAGALYILGEKKLAAELMDKFKWGHTFLELNSSLLEDYANADTKEQVEQLEKEYFPQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN17</accession>
    <name>K0IN17_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdc6</name>
        <name evidence="3" type="ordered locus">Ngar_c16610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16610"/>
    <dbReference type="EnsemblBacteria" id="AFU58594">
        <property type="protein sequence ID" value="AFU58594"/>
        <property type="gene ID" value="Ngar_c16610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16610"/>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OMA" id="ECAARTE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="63"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="400" mass="45167" checksum="ABC30B406FB93EEB" modified="2012-11-28" version="1">MTDYPYPIIAGEEMSESAIFHDRSKLSPRYVPEELPHRQAQIEQIIHVFSDAAKDPDRFPLTILQVVGVAGIGKTSTILRSSKIIEEQFVKSRLVLKTAYINLKLQGGNKYAIYRFLLERIAPELPAQGLSAEEMLRYLLRYLRENKQYALIIMDEIDYLIKTSKDTGIIYDLTRLNEFEPDKPCNVKGVVFIARSTEFYSRLDPAELSTLGRVPMEFHPYSIEQVSDILESRAGQAFNPKAIGSDVIDKVAEITASPEVNGDVRYALDLLLYAGNLAESQGTGRVTLDHVRKVHGQVHPSITTEEIEQLSKNHLVSLMALVRALKSKKKPYVELKDVRLYASELAERLGMKKIDVEDYLDDLKARRLVDIRSLKEIGLHGASLAELEPALMNRIKGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA0</accession>
    <name>K0INA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c20780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20780"/>
    <dbReference type="EnsemblBacteria" id="AFU59009">
        <property type="protein sequence ID" value="AFU59009"/>
        <property type="gene ID" value="Ngar_c20780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20780"/>
    <dbReference type="HOGENOM" id="CLU_192667_0_0_2"/>
    <dbReference type="OMA" id="VEWANHA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2076-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8259" checksum="7B227623345BC653" modified="2012-11-28" version="1">MSSSGPEFGLAAMYRVMKKSGAERVSDDAADELRKVLEEVAERIAKQAVDLSVHAGRKTIKPEDIRFAAKNVIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND6</accession>
    <name>K0IND6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22590"/>
    <dbReference type="EnsemblBacteria" id="AFU59189">
        <property type="protein sequence ID" value="AFU59189"/>
        <property type="gene ID" value="Ngar_c22590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2237"/>
    <dbReference type="HOGENOM" id="CLU_066245_2_2_2"/>
    <dbReference type="OMA" id="MPLVGFD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2257-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="19683" checksum="46D88AC4589FAD8C" modified="2012-11-28" version="1">MLEKRNRLDAQEIVERSKRVQEFLINSKEFQSAKVVGAYYAFGSEVRTDLVIEQTKALGKKVALPSVEGENLTFYELSSGKYLVKGRFGIMEPLPYGPVDRMDLLVVPGIAFDRKGYRLGYGKGYYDKFLAKRKVVFSIGLAYSFQLLDNNLPLGEHDKRLDAIATEDRIIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ7</accession>
    <name>K0INJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59494">
        <property type="protein sequence ID" value="AFU59494"/>
        <property type="gene ID" value="Ngar_c25720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25720"/>
    <dbReference type="HOGENOM" id="CLU_3282985_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2571-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="40" mass="4587" checksum="F8655D56FAB330F0" modified="2012-11-28" version="1">MLPIAILLPTWKMVIETLGPVLDILYESLHDVLQFCAIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS9</accession>
    <name>K0INS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59904">
        <property type="protein sequence ID" value="AFU59904"/>
        <property type="gene ID" value="Ngar_c29860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29860"/>
    <dbReference type="HOGENOM" id="CLU_741065_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2986-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="373" mass="43108" checksum="4F788A64BEA45170" modified="2012-11-28" version="1">MSNHDIISWDSAIGRKVKSSDDKDLGKVQSITRDYIQTKEGTVSKNYYFIPKYYLSGYDGDKLWVSLTRDEVKSKFERENAPEPSEWETPEYAKRRTVVMEKYPEFATSIPANMVQMPWDKIIDKKVKSSDRKDLGDVESVSSDYIEVKEGLVSKKHYYIPKFYIQGFDGDSLYASLTKNEIKDRFERDSPPPPSEFQSADYQERMRRVEADYPQFLHGVPWMAKEPSTEIPVDYSGTTYNIPWDQLIHQHVRTTDNVEIGYVERIGNEFVVVREGVSDVHIYYIPKAYIRDYDGSQLWIDAPSGLVRSKFEREPEPSVEELRTLARDAPRYRKRTVEPQAQRTTTAEPGSVKVETEVDLEEAGRTKTATEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT3</accession>
    <name>K0INT3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative catalase, Mn-containing</fullName>
            <ecNumber evidence="2">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30060"/>
    <dbReference type="EnsemblBacteria" id="AFU59924">
        <property type="protein sequence ID" value="AFU59924"/>
        <property type="gene ID" value="Ngar_c30060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2979"/>
    <dbReference type="HOGENOM" id="CLU_1850704_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3006-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15396" checksum="52D3771C28876DB2" modified="2012-11-28" version="1">MLLEGVSPTSQQPNDLPLSVALDSPNIHHFLVAAQSARPVNAAGNPWTASYVYDSDNLMLEATGRLQKCRLYEMSNNKAYRSTVSYLIVRDLSHEKVFAKALESLGVSWSKALPIPRIDTSGMPEVRDLERKNLHNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX5</accession>
    <name>K0INX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60134">
        <property type="protein sequence ID" value="AFU60134"/>
        <property type="gene ID" value="Ngar_c32180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3207"/>
    <dbReference type="HOGENOM" id="CLU_202921_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3218-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6582" checksum="2BF4D41C80E15E85" modified="2012-11-28" version="1">MKTKARKGDEANKPLLNQINYVLLHLHLAGKHDAKPTHEELKDWLHSGQVDVLRMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX8</accession>
    <name>K0INX8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c32330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60149">
        <property type="protein sequence ID" value="AFU60149"/>
        <property type="gene ID" value="Ngar_c32330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32330"/>
    <dbReference type="HOGENOM" id="CLU_064194_2_2_2"/>
    <dbReference type="OMA" id="ERGYADH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3233-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="155"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="28144" checksum="6124D1CA137C0307" modified="2012-11-28" version="1">MIEIIRSSEHYHNEEDWLSTYWHFSFAHYQNPDKMNFGPLRVFNDDIIQPETGFDLHPHRDMEIVTYVIDGELEHRDNQGNHGIIQPGEIQSMTAGSGILQSEYNHSKEKLLRLLQMCIFANKRGLDPSWEQRRFDRAARLNRLLPVIVPENIKNGQALHIHQDAAIYVSSLTPGSRVEHKLAKDRKANVFVIEGKVKLNDNNSIETRDATKVENENRLSIQADGRPAELILLDLLEKYAVNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY7</accession>
    <name>K0INY7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ordered locus">Ngar_c32790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32790"/>
    <dbReference type="EnsemblBacteria" id="AFU60194">
        <property type="protein sequence ID" value="AFU60194"/>
        <property type="gene ID" value="Ngar_c32790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32790"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3274"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_2"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="439" mass="48397" checksum="7E7462FFCF38ABFB" modified="2012-11-28" version="1">MSAKKAYDDVLKLMREHHDWFDRSIPLIASENIPSPAVREAIMSDFGNRYAEGWPGERVYAGCIYIDQVELICNDLARKVFRAEFADCRATSGVVANLAIYAAFTNPGDWMMAASIPAGGHISHGKKEHAGTAGLVHGLNIEHYPFSKEEMTIDVDATKKKIDEMVREGKPPTMGMFGGSLFLFPHPVKELAEYMHQHGMYVNYDGAHVAGLIAGGEFQDPLREGVDSMTMSSHKTLWGPQGGIIVSLEKHAEAIKKAVFPGNTSSHHLHHVAGKAIALAESLEFGKQYAKQVIKNAKALAEALAGYGFRVLGEKRGYTASHQIAVDVMKFGDGGTIEKQLEKAGIILNRQLLPGDIKAGRHYMHPSGVRIGVPETTRLGMKESEMKEIANFIKRVVIDKQDPAIVAKDVAEFRKQFQKVQYAFDNAVKAYEYISLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP24</accession>
    <name>K0IP24_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34640"/>
    <dbReference type="EnsemblBacteria" id="AFU60379">
        <property type="protein sequence ID" value="AFU60379"/>
        <property type="gene ID" value="Ngar_c34640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34640"/>
    <dbReference type="HOGENOM" id="CLU_703251_0_0_2"/>
    <dbReference type="OMA" id="SINRIDY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3465-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="392" mass="42418" checksum="1F54FFE27E43EF37" modified="2012-11-28" version="1">MTYTCKKRIYFNPYYTDWMPEIWLRYGTTDVVLDIKFENLANQISAGFQLLPEDQVRATVAGVPLTDNMLILALSGSKAAAKTITMLAEEARAKGFNFTVDVPQKMAGALRASLAGNEMISINRIDYQSSLQERMGKFQSTVVISSVAYDPLFGFAGAPTMLLRNLLLAGPIMAEAFKARKDNRPTPGVQGEPLKVAISAATGIPATSVELVASSEGIAGIHTGSINEAFEKAVSQLQSISAVETDPVKCAVISASSEAGTHSTLAGSLNSLWNSVHIVKEGGSAILLAENREGVGGGALQMFIEGRLKPEQLRESPYIDGLEHLLFIEELRQKCELGLVSTLPHYYARTKLGFSTYASMKDILDKLPEKHGKNFRALVLSDADIVLLKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP27</accession>
    <name>K0IP27_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34800"/>
    <dbReference type="EnsemblBacteria" id="AFU60394">
        <property type="protein sequence ID" value="AFU60394"/>
        <property type="gene ID" value="Ngar_c34800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34800"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3481"/>
    <dbReference type="HOGENOM" id="CLU_523398_0_0_2"/>
    <dbReference type="OMA" id="KFAVYAF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3481-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="357"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="529" mass="60635" checksum="ED317DF41BDD06C8" modified="2012-11-28" version="1">MAAATKIASSAMRNDVLLDIATFLSRRWSGNDRVVIILMPDKVPMAKPDKNQITLPLLNYYPGTDFQKYRQWRVALWYESMRMKHSTKVLSYEHAFGFLLNTLETKRIEILGLREWEGMAGELFFNEGISWMSRQLLNSIYGRYKIAEAFSQYFLTGYIKGELFGGEFDKVKRATDYANEIVKEAIDNNYGTEWVEQHIPKLIKMLELDPLVSIPVLAPRTRVGASLNQTDLLKQVEKVVKMRHKKENVEEKTKEIYEGHDVLHEFETLVKESKKTENKGYESLEDFGLSVPDKMDVDETQIYDIDLIQKVKAAFREWKTGWVERHDETGDEFDTESYVEALPKTFISDFKLSIKTKVAILLDHSSSIADVELEYKQATTALCEALHYLGIKFAVYAFSTDKRQVKCWVIKPPNIKWSVVSARRLAQIRASGGTPLAEVYGLLEPVLKSFKPDIFVTLTDGEPSDFDAVRTMVLSYRKMGIRMVAIGVGRNINDSVGIGQNLKYLNYEKAVSVSRLQDIPKRVIKLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7H2</accession>
    <name>K0I7H2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57181">
        <property type="protein sequence ID" value="AFU57181"/>
        <property type="gene ID" value="Ngar_c02330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02330"/>
    <dbReference type="HOGENOM" id="CLU_184936_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-233-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9258" checksum="EE286C027C52EFDA" modified="2012-11-28" version="1">MNIADSEASVVIVAKTCGCTEKRKISYAFSQGYHDLCLDKKDIISAQLEACERLLKYAIEQNDRDALDQEIKELKMALDLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7Z1</accession>
    <name>K0I7Z1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57391">
        <property type="protein sequence ID" value="AFU57391"/>
        <property type="gene ID" value="Ngar_c04440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04440"/>
    <dbReference type="HOGENOM" id="CLU_2875199_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-443-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="6831" checksum="84AB96B524F47039" modified="2012-11-28" version="1">MLDHVFSEDKSGPAIFAHVKGVQSFYRHGANMIPLPITAAFGFKNYGVLLLSRITSFLCAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8K6</accession>
    <name>K0I8K6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57616">
        <property type="protein sequence ID" value="AFU57616"/>
        <property type="gene ID" value="Ngar_c06730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06730"/>
    <dbReference type="HOGENOM" id="CLU_1478960_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-671-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="19967" checksum="AD94D39CF0FD3163" modified="2012-11-28" version="1">MDYSIIFILVAIVLLLISLTIPWVIINFRGQWFYTPIEIVRGITDGNDRNASSFNEKPNFLRFTSVSQEITFDMVLSIITYLVSVGAMIVALVSLWVKRLSKIMLLAGILATIAGIAWIDAIQSFRTAAAASGVDANLINAIVVTGFGPYPVAIAGIIAAFGFFIEKMFRKQEQQDAPTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I907</accession>
    <name>K0I907_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08190"/>
    <dbReference type="EnsemblBacteria" id="AFU57761">
        <property type="protein sequence ID" value="AFU57761"/>
        <property type="gene ID" value="Ngar_c08190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08190"/>
    <dbReference type="HOGENOM" id="CLU_130694_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-817-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7911" checksum="CC465D1732043BB3" modified="2012-11-28" version="1">MRYLVLVRFSSDDRLEVSDDEIAVSIKSQPERGKANRELVKKLAAHFGVGEDRIRIVSGLTSRKKVVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I991</accession>
    <name>K0I991_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57901">
        <property type="protein sequence ID" value="AFU57901"/>
        <property type="gene ID" value="Ngar_c09590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09590"/>
    <dbReference type="HOGENOM" id="CLU_2613750_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-957-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9031" checksum="D7CE9537D3373524" modified="2012-11-28" version="1">MHFLTKEDDAIDRLGQRLAQSHSAHQARIGECSSSSKDKWDAVETNMGGNNPAQTLRYNRQQTNCNQVQINHYKYFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9P6</accession>
    <name>K0I9P6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized aminotransferase OR putativesoluble hydrogenase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c10990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10990"/>
    <dbReference type="EnsemblBacteria" id="AFU58041">
        <property type="protein sequence ID" value="AFU58041"/>
        <property type="gene ID" value="Ngar_c10990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1041"/>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_2"/>
    <dbReference type="OMA" id="IRINHMG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1097-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="376" mass="41401" checksum="3356ABEE0BA32156" modified="2012-11-28" version="1">MLPGPTNVPNRVMNAMLAPVINHRSDDFRTLYKSIVEKTQKVFQTSNDIVLLTTSGTGAVEASVVNLIKKGDKAVIPVNGEFSTRLADLIDSWGGQAIRINAPPGENPPYDKFEEAFDKNKDIKALYAVYNETSTGTTIRYMDKLGQLASRKGAYFIADAVSILGGDELPVDKWNVDICVTASQKALAAPPGVSPVSVSKRAKKYMQENPPPTQYLNLKRYFKYYEEHFETPFTPALPLYYAFREALDMVLEEGMENRIRRHRICADAFYAGLSALGLTPFAKPDARSNMIIAVNYLPGMDDKKFRGLLSSEFKVLIAGGFGDLKGKVFRVGSMGEVGRYHVMRTISSIASAMNMLGVKTNPEATSVAMDKLKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA50</accession>
    <name>K0IA50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c12410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58181">
        <property type="protein sequence ID" value="AFU58181"/>
        <property type="gene ID" value="Ngar_c12410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12410"/>
    <dbReference type="HOGENOM" id="CLU_043491_0_0_2"/>
    <dbReference type="OMA" id="WHADELF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1239-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="5">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="183"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="380" mass="43237" checksum="4BD2FC482EBA419F" modified="2012-11-28" version="1">MTRGLQILESGKNIVENEDGSFTVPSQTSKTTYEVRLIQTTWVCTCPDFEYRKVEACKHIFAVRLFIAANTYIKNEPKPKVFAEDAIPCDKCGSIRVIKFGIANKKQTYYCKDCKHKFRQASMLKKAKFNPELISLTLDLYFSGLSLRKIARSVSDHFNVDIGYATIYTWIQKYIPLISEYVNSLVPKGLSDTWHADELFIRMKDGVQVRNNKSVGIVWNIMDRDTRFLIASKLTEDRGEESAIAAFREAIRNAHAYRAEAKPKQIYTDGHKAYESAISTLFRKKSIRPEHKANCGVAKPHANNNRIERLNGTLRERTKVQRGWKSKQTPLAEGARIQYNFVKPHMALEGKTPAGAAGMEVKGWNELLAKAMDSKRQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB11</accession>
    <name>K0IB11_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CoA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15930"/>
    <dbReference type="EnsemblBacteria" id="AFU58526">
        <property type="protein sequence ID" value="AFU58526"/>
        <property type="gene ID" value="Ngar_c15930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1560"/>
    <dbReference type="HOGENOM" id="CLU_112567_0_1_2"/>
    <dbReference type="OMA" id="MVMDRCP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1591-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15864" checksum="74192BCA66B623DD" modified="2012-11-28" version="1">MQERDAHSDSEIIKFYDLKNIAVVGMSKNEGKAAHYVPKYLIDHGYNVIPVNPTASEIQGRKSYPSVSSVPHKVDIVDIFRPSEDVPAVVEDALKKEGIKVIWMQEGIYSKEAERMAKEKGIEVVYNRCMLAEHERLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBR4</accession>
    <name>K0IBR4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="7">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">trpE</name>
        <name evidence="11" type="ordered locus">Ngar_c17630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17630"/>
    <dbReference type="EnsemblBacteria" id="AFU58696">
        <property type="protein sequence ID" value="AFU58696"/>
        <property type="gene ID" value="Ngar_c17630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1738"/>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_2"/>
    <dbReference type="OMA" id="HGRMDTS"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010116">
        <property type="entry name" value="Anthranilate_synth_I_arc_typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01820">
        <property type="entry name" value="TrpE-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="10">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="9">
        <location>
            <begin position="194"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="460" mass="52472" checksum="ED5DA9B563D20804" modified="2012-11-28" version="1">MVTFGQLAGSSIQIHKLATSENQFELFKKIYSLYDKVFILESLIGPKELAEMSVIGFDPEVTVTCDSKKFTVRDRKGKVVQSSPVTEPLSQLRELMPKVNDERFRYIGGAVGYINYDAIRFWEHLPVKGKKQSNFPLLEFGIYQDGILYNHEENQAYYFFLDKSRLQEVERKMAKVKNKATRFSYSTPRRNMTKQRFIKMVKKAKHYVYEGDVFQVVLAKSMNFTVKGNLIDLYASLREVNPSPYMYLLKISERCIIGSSPEMLIRVTKDYVETFPIAGTRPIVEDEKKNEELRQDLLKDEKEIAEHTMLVDLARNDIGRVCEFGTVRVNELMTVKRFSHVQHIVSHVVGRLQKSYDSYDALKAVFPAGTVSGAPKVRAMEIIDELEPTLRGPYAGALGYFSFNGSCDFAITIRSLFVNGRNGYIESGAGIVMDSDPEREWAETEHKANAMLSALKKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBW8</accession>
    <name>K0IBW8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57045">
        <property type="protein sequence ID" value="AFU57045"/>
        <property type="gene ID" value="Ngar_c00950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00950"/>
    <dbReference type="HOGENOM" id="CLU_646582_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-95-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="424" mass="44702" checksum="B991B80AD7612D83" modified="2012-11-28" version="1">MRSKNAFAILAGALLVAAMLIMSATVPPSAYADTDDDNGKNKSKDKDDKKEKRNEKLERVASILKKLNNDAKTILPSSGTLTVNASGLAVERSNNGRTGVADAKLDMSGSILKVEGSHVRVMFNGTLDIDGQEYEIDAEGKVKLSRSGHGTGLLEIKGRTDDDDDRDKFTLKATILPSSQSREWKIVTTMPTAKLGSHIKIYLIGEMHLSGNTGGGSGGNTQLSHFEISHIANQTAGNQFTFTVKAIDTNGHVKKDYNGTVTIKTNDGSSPMGNASSFAPNPYTFNATADNGQHTFTAKLYNAKSNVTIITVSDSGGKTGTSNKFNVVPEAAASVKVMPVNVTVPSNATQNFNATAYDAYGNWVDADFTWSLNSTAVGTLTPSATDSSKATFKAAVVSSNINGTITATVAGTMVQSTAKVTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBY2</accession>
    <name>K0IBY2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58816">
        <property type="protein sequence ID" value="AFU58816"/>
        <property type="gene ID" value="Ngar_c18840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18840"/>
    <dbReference type="HOGENOM" id="CLU_176747_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1882-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12072" checksum="DB368FA4956E68B8" modified="2012-11-28" version="1">MSERENREQIPTEFNAEQTQRTLRRQDRVEGGQREKTVSDFPSAAALGQVLKDLDFPADKSSIIRFVEQSNKLERNEVLPLVQKIEERQYQNVSEVAEAARLVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC02</accession>
    <name>K0IC02_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58856">
        <property type="protein sequence ID" value="AFU58856"/>
        <property type="gene ID" value="Ngar_c19240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19240"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1903"/>
    <dbReference type="HOGENOM" id="CLU_184938_0_0_2"/>
    <dbReference type="OMA" id="CPNFQSR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1922-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10794" checksum="6C077CB728A6BC3E" modified="2012-11-28" version="1">MAEALPDGVKHLVAIKQVEKSIKLTDQAKAELQSSGMMDEKGKLKIKGVSPKMLKRMKLESVDCPVLKQEVGFLQCYVCKNFHSRISGQVYCKGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICD5</accession>
    <name>K0ICD5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59041">
        <property type="protein sequence ID" value="AFU59041"/>
        <property type="gene ID" value="Ngar_c21100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21100"/>
    <dbReference type="HOGENOM" id="CLU_2613754_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2108-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8818" checksum="7408217A0F01FEA3" modified="2012-11-28" version="1">MNRIVANMPFFKLMQYVTYKASWESVPVLTTKEWYSSKFATDAAVIIRQGHIRACSCVMPVVTLATLTTMEQSILEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICE9</accession>
    <name>K0ICE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59051">
        <property type="protein sequence ID" value="AFU59051"/>
        <property type="gene ID" value="Ngar_c21200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21200"/>
    <dbReference type="HOGENOM" id="CLU_2476121_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2118-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9917" checksum="B7CD8ACF0A7447C6" modified="2012-11-28" version="1">MPGQETTCKIELINYIELLSLRLYCCIFYFYSLCSLFAMVLNIPDAKTVLPSLQRRRKGCIEVTDERKIALPKFHIKCAVCGKLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICK5</accession>
    <name>K0ICK5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="4">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thi4</name>
        <name evidence="5" type="ordered locus">Ngar_c21660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.59" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21660"/>
    <dbReference type="EnsemblBacteria" id="AFU59096">
        <property type="protein sequence ID" value="AFU59096"/>
        <property type="gene ID" value="Ngar_c21660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2145"/>
    <dbReference type="HOGENOM" id="CLU_053727_2_0_2"/>
    <dbReference type="OMA" id="GIVMNWT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2164-MON"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00304">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022828">
        <property type="entry name" value="Thi4_prok"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00292">
        <property type="entry name" value="TIGR00292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="29548" checksum="49A7F94C5335635C" modified="2014-02-19" version="1">MAKIFADVSEKEITRTIADMFNETMREYTDSDVIIIGAGPAGLTAGRDLAKAGVRTLIIEQNNYIGGGYWVGGYMMNPVTVRAPAQKVWDELGVPYRKISEGLYATWGPNACSKSISAACDAGVRFLQLTKFDDLVLKNKRVSGVVVNWMPVSALPRNITCVDPVALESKLVIDASGHDSVAVRRLMDRGYVKWKGMDPMWVEGSEDAVVNYTGEVFPGLIAAGMSVTETHGLPRMGPTFGAMLLSGKKAAEVALGKLKEMSNPPKLTSRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICK8</accession>
    <name>K0ICK8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59101">
        <property type="protein sequence ID" value="AFU59101"/>
        <property type="gene ID" value="Ngar_c21710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21710"/>
    <dbReference type="HOGENOM" id="CLU_2730558_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2169-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6672" checksum="D3902D1AF223BBAF" modified="2012-11-28" version="1">MEKMTYCTKCKDTVVISNAKYTRLANNRAIIEGFCSRCGDHLIKASIMPKSFTLKVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICL1</accession>
    <name>K0ICL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57355">
        <property type="protein sequence ID" value="AFU57355"/>
        <property type="gene ID" value="Ngar_c04080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04080"/>
    <dbReference type="HOGENOM" id="CLU_786669_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-407-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="342" mass="37749" checksum="22D1BC19B130F444" modified="2012-11-28" version="1">MQLSFLNRKMCWLYFVVTSFLLAGTFSLNAYGAGGHDLPPSSIGDRQVFLSFSAPSIADPSDRIAMSYSFMDKATGKNVQHVTYFLTISNPQGKQTFSEVLHGHDGTVNVQFRPGEGQYKVNANYDNLAASYVADQAGVITVSGPVFNEQGSYKVNIEVNGIDYDNTFLPEPIKYEYPLVVAAAQKFAVPYVEMAFNVNVSSPLQVENVEFKPENKQLMIQYSGVEWQHFDDFQVYVEIPREMMSGPFTAIFNGMELMVREEQKDGRTTTLILNGTHLDLMQMNQSGDSMGGMDMGESQQQNAIVITATSVVPEFPLTLPLAAVAIASAIVLASKFKGRPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICP2</accession>
    <name>K0ICP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59136">
        <property type="protein sequence ID" value="AFU59136"/>
        <property type="gene ID" value="Ngar_c22060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22060"/>
    <dbReference type="HOGENOM" id="CLU_2505065_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2204-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9430" checksum="5D49FB783BA47A08" modified="2012-11-28" version="1">MAVCIVCGKYEEVGLKGAMGNGWVFTRCPECQRGTPFDIAAMHLTKSIPEHYLEGFCPKHWFKDSGICSYCKIRRGTLGLGEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICR4</accession>
    <name>K0ICR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA/RNA-binding protein Alba</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">albA1</name>
        <name evidence="2" type="ordered locus">Ngar_c04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04910"/>
    <dbReference type="EnsemblBacteria" id="AFU57435">
        <property type="protein sequence ID" value="AFU57435"/>
        <property type="gene ID" value="Ngar_c04910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04910"/>
    <dbReference type="HOGENOM" id="CLU_1500325_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="19156" checksum="781ACE4BAF37F8BE" modified="2012-11-28" version="1">MMTAIVEQKTSLEPRLHVPPAVLLIGKKRTLDYVAPALYRINSTGELIIKAIGSLSIVTAVDVAEIVKRDVDVLTKSITVGTDELRIATGEIKRMSCIEIHLIKNNPIAVVPPAIDVHAPVEEAAAPVEISIEAAPDVAATVEVPVVVAEEKAKKPRAKRSSTTAKKKSSKKKKNSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICX9</accession>
    <name>K0ICX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57520">
        <property type="protein sequence ID" value="AFU57520"/>
        <property type="gene ID" value="Ngar_c05770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05770"/>
    <dbReference type="HOGENOM" id="CLU_2177768_0_0_2"/>
    <dbReference type="OMA" id="CYEETIC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-575-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="13083" checksum="8978A0DC0C410E4E" modified="2012-11-28" version="1">MTTNEQVTLDSWVMSRLRDRLRRASIIASRTGKPVVLYRHTIEEVDHSAEEEIATVNEQYVVVQVITHGGFIPPNFQQQFVFTFEQFPEWIMKRSNELLSLCLESLDQEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID00</accession>
    <name>K0ID00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carbamoylphosphate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23250"/>
    <dbReference type="EnsemblBacteria" id="AFU59251">
        <property type="protein sequence ID" value="AFU59251"/>
        <property type="gene ID" value="Ngar_c23250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23250"/>
    <dbReference type="HOGENOM" id="CLU_052967_4_0_2"/>
    <dbReference type="OMA" id="AYLHAYG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2323-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="123"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="347" mass="38042" checksum="485AAA7A14034575" modified="2012-11-28" version="1">MNARVLVTAAGSIVAQGIIKSLKLASKKGDIRYTIIAADMSPLAAGLYRCDSGILVPPVSSPDYIDSVAKVCSDNDVQAVFCGSDDELLALAGAKEAIEKTGAKLLTGPLEALAIARDKWATYEFCRANGLACAPSSLPEERDAFVREFGFPVVVKPREGYGSLHFYIAKSKQEMDSSILAIERAGWRPLVQKYLAGDEFTTGVTIDRNSTYAMSSISIRKMIKHGQTYKAFIDHYHSVCRSAEDVALKLGASGPINVQAKLEGEAPVVFEINPRFSATCPMRAAAGVNEPDIVFRNTVLGQEVKINSYERLVCMRYWNEVYVPYLVYEKALHGRRVEKGSFVPDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID95</accession>
    <name>K0ID95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trxA2</name>
        <name evidence="3" type="ordered locus">Ngar_c24420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24420"/>
    <dbReference type="EnsemblBacteria" id="AFU59366">
        <property type="protein sequence ID" value="AFU59366"/>
        <property type="gene ID" value="Ngar_c24420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2415"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_2"/>
    <dbReference type="OMA" id="WRESGRI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14177" checksum="173985F89D84BD63" modified="2012-11-28" version="1">MTKYKIPFCTILPMESKTDSNSVTHVTTKTWDAEVLRSDLPVFVDFWAEWCGPCRMVGPAVEQIGKILAGKVKVAKLNVDENQQIAMKYGVQSIPSLILFKGGKEVARTIGAAPKEAYLKFIENSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDI2</accession>
    <name>K0IDI2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-2-macroglobulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c07680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57710">
        <property type="protein sequence ID" value="AFU57710"/>
        <property type="gene ID" value="Ngar_c07680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07680"/>
    <dbReference type="HOGENOM" id="CLU_870494_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-766-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MG2" evidence="2">
        <location>
            <begin position="66"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="319" mass="33890" checksum="023A9680C7203D2B" modified="2012-11-28" version="1">MTTARDNRANPVATSIVLMMTAAILLPSAIQIAYAQSSSAGASTEVQTVYKSSYPKASTSSSSSVSVQSEYHIYKPGDTVKIQGQMSSEAKEQTDADSVMVRIMDAQGTVVANQQATVNGNGEYAASISLPPTAAEGEYNVSSKIEVEASVLGLLDAEVIAKLESPPAQFIVARSNAFEVQSDEGEEFQIEITSNSNVDNVEFKQAEKRVSFVVEGKTGTTGVTEITIPKAMLSGEMMVLIDGEVVTAESNDVIVKSHTDTEITFEINYSHSEHTVEVTGTNVTPEFPVSILVMAGALGSIIAFAAARNRGNWFNILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDL1</accession>
    <name>K0IDL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme-copper oxidase subunit I</fullName>
            <ecNumber evidence="3">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">coxA</name>
        <name evidence="3" type="ordered locus">Ngar_c25640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25640"/>
    <dbReference type="EnsemblBacteria" id="AFU59486">
        <property type="protein sequence ID" value="AFU59486"/>
        <property type="gene ID" value="Ngar_c25640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25640"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2541"/>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_2"/>
    <dbReference type="OMA" id="PVDFQYH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="509" mass="57100" checksum="6569A89137BCDDAB" modified="2012-11-28" version="1">MVLEVKKPRPMWEILFSTHHTDVGLLYVYLSLTAFIIGGALAIAIRTELFLPGDAINIIPDSNTFHRIFTVHGTNMLFLWLIPFASGIGNYLIPIMVRYKDMAWPKLNAVAFWMIPVGMALIWLGFADTTWNAYPPYSIIRAPGPAAEMWIFGLKILGISSILGAINFIVTILRMKHPDLPLMKTSLFVWSTLVTSLMIIVAIPTFAAALIMLYTDRLGVSGFFNPAMGGDPIAYQHLFWFTFHPEVYIFLIPAVGMMYELIPKFSRKPIFSYQSGVAAFVLLAIVGFASWAHHMYATGMSFTEKTVFMVGTLAAVPASAMHVFNWIATMWGGRIKFAAPMSFAVGGLVLFFYAGAGGIVNTAMPLDFLTHDSYWVVGHFHLFVMGLVTFAFIGFIYYMFPFITGRMYSERAAMVQFWLMFVGVSMIFLTQHVLGLYGQPRRVFDYVPVQPLIIMNQISTVGAWITAAGAAIFVWNLIKSTVSGKPAKMDDPFAIGEQYYDYTRREPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDN9</accession>
    <name>K0IDN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59511">
        <property type="protein sequence ID" value="AFU59511"/>
        <property type="gene ID" value="Ngar_c25890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25890"/>
    <dbReference type="HOGENOM" id="CLU_1850535_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2589-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15647" checksum="1393E57655BCDBDD" modified="2012-11-28" version="1">MAKTISVRRKGYKRKGYTATRRGGKKVKVSPARVKPSTFKIRDRGKAGRGPKVVPPLEEGALGGPGFFDRSEAEQEQIAFERARDVGEKKAVGELRALQVFFKKTDPEKSKRALELSKKVAGSFKGKQEVEYPEGLRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDT6</accession>
    <name>K0IDT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC uptake transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c00280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00280"/>
    <dbReference type="EnsemblBacteria" id="AFU56978">
        <property type="protein sequence ID" value="AFU56978"/>
        <property type="gene ID" value="Ngar_c00280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00280"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="HDMSLAR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-28-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU56978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="258" mass="28493" checksum="823AC25B37D7C488" modified="2012-11-28" version="1">MQTTTVVVEIDKLSYAYSGSLVVLDNISFSINEGVLLGMIDPNGAGKTTLFSCMLGLLGDYTGTIKIFGRDIRKDSKEALKSIGYIPQKKTIDQNFPATVEEIVSLGITTGNKISKDKIGSALDTVGLLAQKDRRVSKLSGGQQRVLIAKAIVNDPKLLILDEPATGIDLETQNKFYALLKKLNQEKKITIIWASHDLDAVNRIASSVACVNRSMFFHGKIHEFFENADLLKAYSESSMQAHMHMHDHHHDQHDHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE11</accession>
    <name>K0IE11_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rad25</name>
        <name evidence="6" type="ordered locus">Ngar_c01080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01080"/>
    <dbReference type="EnsemblBacteria" id="AFU57058">
        <property type="protein sequence ID" value="AFU57058"/>
        <property type="gene ID" value="Ngar_c01080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01080"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.112"/>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_2"/>
    <dbReference type="OMA" id="PAITHQT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="358"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="543" mass="60507" checksum="B373249221B48FCB" modified="2012-11-28" version="1">MIKEPVLKATLNYDRGTIVIRGLAHIPFATPDPRSNNNNILRAQALYYVNIVEYLKQSGIEFADYVFSDVIASPDLNSSNNNDDDGGIVVKQNKATATAGIAIASSLVSLRDYQQKALDNWIRAGMRGSVVLPTGSGKTIVGIKAIETVNASSLIIVPTLDLMDQWTAVLSKYFHQPTKIGNLGGGIDDVQPITVSTYDSAYLRAPLLGNKFSLIIFDEVHHLAALGYRTIAEQMAAPYRLGLTATIEREDELHRDLPRLVGEVVYQASPDTLAKKKHLASYEIERRRVELLPEELKEYRENMSTYRQCLNKIGKTMGGYYNLSLEKLIMISGKNPTARQALLARNKATNIALNSKAKIEELKEILAENQGKKTIIFTQHNSLVYQISDKFLIPFITYKTNKDERQDVLTGFKEGRYMAIVTSKVLDEGIDVPDAELGIIVSGTGSAREFIQRLGRLLRPKPKAATSGAATDDEKEDSSRRSKKAKLIEIISSETREETITGAKRKRALRSIRQDGEEEGDEEDHINKQLQEEAEYTTNNRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IED5</accession>
    <name>K0IED5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c02100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02100"/>
    <dbReference type="EnsemblBacteria" id="AFU57158">
        <property type="protein sequence ID" value="AFU57158"/>
        <property type="gene ID" value="Ngar_c02100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02100"/>
    <dbReference type="HOGENOM" id="CLU_023978_4_2_2"/>
    <dbReference type="OMA" id="PRNLHIM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-210-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="177"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="531" mass="58559" checksum="E5890382BBBFC57D" modified="2012-11-28" version="1">MASKVKDQVQRSARSGGKNDGDKTSFSSSLPSGNNNNIINRSTVLFSVLAIVTLVAVTLAIGAIDVYLAAACALAGNIYLLWLLKSAQTKKKQKKKLGRKRGFAPVLLVGIGPVVGSLVFFFLGYLGSPAEAITRMLMTVGFSISLFVSSFPLPLAIKFKLLEGRQQNQESYRPLVTILVPAYNEQEVISRTLESLMNLKYGNKEIIVIDDGSTDLTPVIASWYRQFGVKVLRKPNGGKASALNYGLLFARGEIIITIDSDSMVERDAINKIVSIMRDENMLAVAGNIRVLNSNSMLTKIQELEYLMSINMLRRAFALFGSVMVVPGAFGAFRKRETIQVGSYDNDTITEDFDLTIKLLKTGGAVGSSSAGLAYTEVPSSWKVLYKQRLRWSTGTYQTIFKHRDVIWNTRYDLLHSLVFPMILLSLFNPITSFVGIGAGIYLALTGGLLIFLGMQLIFLIVQVFMSLVALSIDNERYRLALYSPFFVLVYKQVIDFTTLVSAFRAAFSGSKQWHKIDRSGGMQAIKVSNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEE0</accession>
    <name>K0IEE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59696">
        <property type="protein sequence ID" value="AFU59696"/>
        <property type="gene ID" value="Ngar_c27750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27750"/>
    <dbReference type="HOGENOM" id="CLU_2766239_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2775-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="8032" checksum="40AF7009FCB8C103" modified="2012-11-28" version="1">MNVLIAGDRKIHNTFIQNVSSFVSTRQEIPFDFREVWINCPTHKIMITSTSDCPNCDEENNLYLQPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEG5</accession>
    <name>K0IEG5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28110"/>
    <dbReference type="EnsemblBacteria" id="AFU59731">
        <property type="protein sequence ID" value="AFU59731"/>
        <property type="gene ID" value="Ngar_c28110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28110"/>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_2"/>
    <dbReference type="OMA" id="SDCEHPG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2811-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="389" mass="42420" checksum="B093CC16639F716B" modified="2012-11-28" version="1">MSDIDDQIRRDFAVTKKTIYMNNGAIAPTPLSTIKAVTDFLLKCAEAGPDAPQTFDYVMSLLDELRTRVAHLINCERDEVVLVQSTTEGLNMVANGIGWQAGDAVVVRGGRHEHYANYLPWVSLSQRKGVQLRELAIDGETGYFDLADLEKSIKGARLVTMSHVLYNTGAIMPLEEAGRIAQENNALFCVDAAQSAGTIPIDVKKIGCHFMAFPGFKWLCGPTGIGVFYCSKKASEMLTPPSIGIESAMLSEQNIIAYFDMPTKFQAGFRNFPGAAGLEASLRYILRIGLENIRKKNMKVAGALRDEIGKIPGVRLYGPGDENKRTSIVTFMTPAADSSTIVKKLEQDNIIFAARDIGGGKKAVRAAPHFFNSEEEAATAASYVKGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEH7</accession>
    <name>K0IEH7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trxA3</name>
        <name evidence="3" type="ordered locus">Ngar_c28260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28260"/>
    <dbReference type="EnsemblBacteria" id="AFU59746">
        <property type="protein sequence ID" value="AFU59746"/>
        <property type="gene ID" value="Ngar_c28260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28260"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_2"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13189" checksum="F964FD49D4E9CB3D" modified="2012-11-28" version="1">MSEDKKTASMHAASNNLIELGEKNFDEVVGGSKPVLVDFWATWCGPCQFMLPIFDKLSKKYGNKVSFGRLNVDDNQGVAMRYDVYAIPTFIMFMNGKAVDRAVGAVGEKGLEGLLQKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM5</accession>
    <name>K0IEM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28870"/>
    <dbReference type="EnsemblBacteria" id="AFU59806">
        <property type="protein sequence ID" value="AFU59806"/>
        <property type="gene ID" value="Ngar_c28870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28870"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2887-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="15526" checksum="8BC1BF51289AD832" modified="2012-11-28" version="1">MLSPATKRIMVVDDEHDIVAIIQNILKRYGYNNVDSFTNPIEALHEFEGANGSSYDNNRYDLLILDIRMPVISGYEFAKKAKSIDPKIKVILMTAFEIDDDKSRQDLPVMKYDELVKKPFALNSICKAVERQLASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEX1</accession>
    <name>K0IEX1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57343">
        <property type="protein sequence ID" value="AFU57343"/>
        <property type="gene ID" value="Ngar_c03960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03960"/>
    <dbReference type="HOGENOM" id="CLU_1965630_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-395-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="15036" checksum="CFF325E5AD187CEF" modified="2012-11-28" version="1">MIIVQGSCIDFENERPKIMEFIGTLEWGAHEKGKIECSSSGKALGWDFFHIYFDPDFVGKLLDIYPDIQKQEGNDIEQRFVLWLSKQMKKSKLEYYLKLSDVPRETVRGFRLNPDHYRDDSELEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF52</accession>
    <name>K0IF52_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58415">
        <property type="protein sequence ID" value="AFU58415"/>
        <property type="gene ID" value="Ngar_c14790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14790"/>
    <dbReference type="HOGENOM" id="CLU_2766234_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1477-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7924" checksum="33CE90519033AD02" modified="2012-11-28" version="1">MLYNNDAYVKYIKELYHNAMALPHSGLRLNNLFSREKTCACGHPAKYHIQGFSKCLFGVCGCDHYYNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF79</accession>
    <name>K0IF79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60021">
        <property type="protein sequence ID" value="AFU60021"/>
        <property type="gene ID" value="Ngar_c31050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31050"/>
    <dbReference type="HOGENOM" id="CLU_1933328_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3105-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14058" checksum="915B4A373C044664" modified="2012-11-28" version="1">MAATIIPDWKVSGDWFNVCSCDVPCPCIFAQTPTNGKCEGVLAYHINNGNYGETPLNGLNVLMVGGFKGNIWADEAKDAAAAFFFDERGNEKQREALQMIFLGKAGASWQNLQGSSEIFGESSLSLSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFD5</accession>
    <name>K0IFD5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein, TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60081">
        <property type="protein sequence ID" value="AFU60081"/>
        <property type="gene ID" value="Ngar_c31650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31650"/>
    <dbReference type="HOGENOM" id="CLU_876080_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3165-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="317" mass="35440" checksum="5FB1FA8490CC33D2" modified="2012-11-28" version="1">MGADLEITAQVRIVTSVAPYVTAANALQAIKLAHEDGFSGVELNEDHLHQLVQVKPNCLRLMRTYSADKHMINSLHKTLHRPSIDSPDQSERKRAVEYTIKTLDYMEVAGIYRMVLHSFSDLPAFFCLKGECANKAGYFVGCNAVKIYGIFAPVLKAYRQTRKKEFQENFVHSLSEIAKYAADRNVDGKPIEIVLEEHYSDAIDYDSVPYGRGNFANVIRGIDTAHQLIRTGRNTDLSEINELIHFHAVDTNGVIDDHRTIGRGKVNFENSLSTAIGKNLTDTIVLEDGTRNSALKSKEVLISMIRRISTTVSSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFL8</accession>
    <name>K0IFL8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60156">
        <property type="protein sequence ID" value="AFU60156"/>
        <property type="gene ID" value="Ngar_c32400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32400"/>
    <dbReference type="HOGENOM" id="CLU_3338598_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3240-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4005" checksum="2A49312350F18446" modified="2012-11-28" version="1">MQKKGRLQQAACVELVQVVLSIFAHGSRQDAVHVISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFV8</accession>
    <name>K0IFV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57693">
        <property type="protein sequence ID" value="AFU57693"/>
        <property type="gene ID" value="Ngar_c07500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07500"/>
    <dbReference type="HOGENOM" id="CLU_149772_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-748-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14832" checksum="395B14512648D254" modified="2012-11-28" version="1">MEQFERLQEKYLPKVDRRLAIDLLLRLREQPNIKPMYVVETFLEEGGNSEEIRNEVIRMTGTAPQLHDRATHLVARHRLDYELLKQIQDHPKVKEVTGTYVGSEASIGASHEPSTAASRRESQRRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGC3</accession>
    <name>K0IGC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58850">
        <property type="protein sequence ID" value="AFU58850"/>
        <property type="gene ID" value="Ngar_c19180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19180"/>
    <dbReference type="HOGENOM" id="CLU_1782542_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1916-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="16272" checksum="DFCC25576D82C7BC" modified="2012-11-28" version="1">MSADSKRVFLEVGSCRAHSKYGNMGYLLDQNYAMHDSAKNAVKLTDYSTMITSYLTDHFSEIIPNGNGELHSLGLFLGKNIQFIPNDTGRAIVPDQIHEFMKKNAVFERAFGRGVGENFELLDEALQMLILEHVGHSYRIWCGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGD7</accession>
    <name>K0IGD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57893">
        <property type="protein sequence ID" value="AFU57893"/>
        <property type="gene ID" value="Ngar_c09510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09510"/>
    <dbReference type="HOGENOM" id="CLU_777594_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-949-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="356" mass="41015" checksum="4F396ADF91E0BB63" modified="2012-11-28" version="1">MDETTFRILDTLARGLGIELSIKALTEKIGELYGSAYYVNIYKKLQQLAEEGIVRLTRMGNSLIVGLNFKEYMITDLLTEMEFRNKQTLLREHRELQMLFLELETYCRDLLFVRSISIIKPYKNAKLNRAELLFLIRAHGMSFYPDEKEAETLRNMVLQLQAIHNMKIDFLILTDAKFLDMLSSDEINPLKEMISDKITFFNPQNFWMAIKVAAERNIPVKAEEKEISPAKIPEQDLVYNLARFGYKEMGTQMPAHGRNICIEYIATALIAQGDARRIEAVPVILAKNSVNFDILLFLSQKYRLSERMLGLLKILQEAVPRNDSEAVIKAMEAMKIKEIPADKKSILEKMGLYNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGU2</accession>
    <name>K0IGU2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl10p</name>
        <name evidence="2" type="synonym">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="4" type="ordered locus">Ngar_c00870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00870"/>
    <dbReference type="EnsemblBacteria" id="AFU57037">
        <property type="protein sequence ID" value="AFU57037"/>
        <property type="gene ID" value="Ngar_c00870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.88"/>
    <dbReference type="HOGENOM" id="CLU_053173_0_0_2"/>
    <dbReference type="OMA" id="MAHVAEW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="3">
        <location>
            <begin position="119"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="298" mass="32790" checksum="BC278AB677101275" modified="2012-11-28" version="1">MSSQMTAPQQARKHYPKKKRLMYQELQELPTKYNVIALSKMTKVRATQLMAIRKKFRNDVKIRIIKNKVAIRAFEKVKGVAGIENLSKQLEGQCALMFTNISPFKLNLIFAQNKVFLPAKGGDIATKEVVVPAGNTGIAPGPVLSEFKVANVPTKIDQGTIWVSKDTVVAKPGDVISMQLASLLSKLNVKPIEAGIAVNFAIAEGLMFKEQDLRIDLEEYKTELVRSFQQALALATEAGYMTPETIKPLLVKAQQQARSLAAEAGYVTPETADFVLQRAQAKAQAVANKAKEKGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGU9</accession>
    <name>K0IGU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00920"/>
    <dbReference type="EnsemblBacteria" id="AFU57042">
        <property type="protein sequence ID" value="AFU57042"/>
        <property type="gene ID" value="Ngar_c00920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.96"/>
    <dbReference type="HOGENOM" id="CLU_119426_0_1_2"/>
    <dbReference type="OMA" id="GIMECAC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-92-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="15605" checksum="9FC9E79FF7A5BFE5" modified="2012-11-28" version="1">MDFAIRAGATKERTITVDSNQTTSFLWEGENVLSTPSMIAEMEETCRLLLKEQFLPDPEWDSVGTIVDIKHLAATPVGAKVSLRARVISVEGRRVMFEVEARDKLEKVGEGRHERFIINVPRFRAKFNEKQKQLGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH01</accession>
    <name>K0IH01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11780"/>
    <dbReference type="EnsemblBacteria" id="AFU58118">
        <property type="protein sequence ID" value="AFU58118"/>
        <property type="gene ID" value="Ngar_c11780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11780"/>
    <dbReference type="HOGENOM" id="CLU_2712962_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1176-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8617" checksum="A39D6AD54B93A9BC" modified="2012-11-28" version="1">MRSRTLGTSGHHVYEPLTDYYVLRRSTLRERILQKYPSFLEKVLYSSLLKMKDVSRKKIIDYIIIKACPIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHC3</accession>
    <name>K0IHC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58298">
        <property type="protein sequence ID" value="AFU58298"/>
        <property type="gene ID" value="Ngar_c13600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13600"/>
    <dbReference type="HOGENOM" id="CLU_2505061_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1358-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9972" checksum="1C29658CF122295F" modified="2012-11-28" version="1">MALIAEDIELLDWLQWPYINTTTLNPDDEQRAHRIFGTIAGRVGTQARLNDIEEYLNTNGSRYREWVIDDLMKIAKSQFARYGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHD0</accession>
    <name>K0IHD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/ribitol dehydrogenase family protein</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdr2</name>
        <name evidence="2" type="ordered locus">Ngar_c13700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13700"/>
    <dbReference type="EnsemblBacteria" id="AFU58308">
        <property type="protein sequence ID" value="AFU58308"/>
        <property type="gene ID" value="Ngar_c13700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13700"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_2"/>
    <dbReference type="OMA" id="APHIRRY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="288" mass="31572" checksum="1948A28EFC2D1BD4" modified="2012-11-28" version="1">MANLEGKTCLVTGATSGIGKEIAMGLAKMGATVVLVGRNRERCELALQEIKAEINPAMEDKRISYLVADLSSQTSIRQFAKQYTDAHQRLDVLVNNAGVFLAKRATTVDGIEYTFAVNHLAPFLLTNLLIDIIKASKPSSRIITTSSVAHRGAQIDFDDIQFEKRPYSGIKAYAQSKLANILFTKELARRLEGSSVTANCFHPGAVRTSLAQGKNPWYYRLIWTAAGSFFLSPEKGADTAIYLASSQDVNGITGKYFVRRKQVNPSIDADEKEAAAKLWSISEKLTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ2</accession>
    <name>K0IHJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59410">
        <property type="protein sequence ID" value="AFU59410"/>
        <property type="gene ID" value="Ngar_c24880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24880"/>
    <dbReference type="HOGENOM" id="CLU_2550384_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2486-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9341" checksum="BC51543517831ADA" modified="2012-11-28" version="1">MKKKSVNRADMADMQLALKKTLDLFGGDSRDLLLFYLYKEHGISVYDPDNLSRKKIESAFSDLFGRGATILMEKFNSEMKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHL9</accession>
    <name>K0IHL9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">psmB1</name>
        <name evidence="9" type="synonym">psmB</name>
        <name evidence="11" type="ordered locus">Ngar_c14720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14720"/>
    <dbReference type="EnsemblBacteria" id="AFU58408">
        <property type="protein sequence ID" value="AFU58408"/>
        <property type="gene ID" value="Ngar_c14720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14720"/>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="HKQAYAI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005066626" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023231604" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="219" mass="24204" checksum="4C4EF8FE3C6ACA2A" modified="2012-11-28" version="1">MHPQDKRYPDYIADQIKKGTTTCALTCKDGVVLAADTRASAGLFIADRHVMKIQKVDQHLAMTIAGGVADAQNLVDTMRYNANLYRFQNKELMPVKSAARLCSNILFNQRYFPYYVQIIMAGYTKNEGSQIHNIDLFGSMTTEKFISTGSGSPVAYGYLESEYRDGMSVNDAYKVAMQAIAAAIRRNAGTGDSINVVIIDKNGYRELSKEEKAAVGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR1</accession>
    <name>K0IHR1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25530"/>
    <dbReference type="EnsemblBacteria" id="AFU59475">
        <property type="protein sequence ID" value="AFU59475"/>
        <property type="gene ID" value="Ngar_c25530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25530"/>
    <dbReference type="HOGENOM" id="CLU_1870806_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2552-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="15564" checksum="0BDD3B69294F0CF4" modified="2012-11-28" version="1">MPKFSQIIKVKSPPEKTWAIVGDLAGVNRWIPRITGVKIEGNKKRTCTFADGHIQHEEIIEYSSEKRSYSYTIERLQRIKNNRGTFAVKQYGDGSVIMWESEFDIINSALEAEMTQMWKGATAQIAESLRRLVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT0</accession>
    <name>K0IHT0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59495">
        <property type="protein sequence ID" value="AFU59495"/>
        <property type="gene ID" value="Ngar_c25740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25740"/>
    <dbReference type="HOGENOM" id="CLU_1399782_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2573-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="194" mass="22792" checksum="AC0CF9418607381E" modified="2012-11-28" version="1">MLFLYALKAPATKEKYIQRLTKFLDFLGYQGTKEEKARAIAARAKADLNYGFNSVLKFFQVKREQIDRKETAIGTVRNYAKSIKLFCDMADLQIPRAKITRGLPREKRFADDRAPTLQYLSNVALTADHGFIRFHGRNKGYWYNCSYDEQELKPWVSKVNKIRKDPEAKRLRIYFNNHYWAKAVANALEFKEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0II56</accession>
    <name>K0II56_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">srp54</name>
        <name evidence="12" type="ordered locus">Ngar_c26940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26940"/>
    <dbReference type="EnsemblBacteria" id="AFU59615">
        <property type="protein sequence ID" value="AFU59615"/>
        <property type="gene ID" value="Ngar_c26940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2669"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_2"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="115"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="116"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU59615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="459" mass="50662" checksum="C3626FB3A2F8E8ED" modified="2012-11-28" version="1">MFDNLREGLRGALKKIVGASDINEEIIDSLCKDVQRALLQSDVNVRLVLSITQNLKERALKEQPPKGLSRKDHIVTILYGELAKMLGYSGEVIKTIDKAQEDERSLATSFFNPGKQNIVLMLGIQGSGKTTVTAKLARWLTKHGYRVGVIGADTWRPGALTQLKMNCSKINVEVYGEEDAKDAVAIARNGLKHFEDQKLDVIIIDTAGRHKEEEGLLQEMTEMHKVVTPDLVLLVIDATIGQSAFKQAEAFHKAAPVGGIVLTKLDGTAKGGGALAASAATGAKVMFIGTGERIDDLEQFSPTRFVGRLLGMGDIKALLEMAKGLELQADEDQVKRIAKGKMTIEDFYAQMDSASKMGFRNIIENLGMGGMIKEDKVEEMQVKMERWRFIIQSMTKEEKKDPNIINESRRKRIARGCGLTEGDIKEMIKQYNTSKDIIKHNKGRGGLGDLFRRFGGNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC9</accession>
    <name>K0IIC9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57782">
        <property type="protein sequence ID" value="AFU57782"/>
        <property type="gene ID" value="Ngar_c08400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08400"/>
    <dbReference type="HOGENOM" id="CLU_1418635_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-838-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="21910" checksum="BB2B330C4B50804D" modified="2012-11-28" version="1">MADMSSLVDPSCREHVILLYDSDDERNEVAINYINEGIRKGQLAVYASVNASDKMFMSKISSKIVGYDDNVNNGNLLILSLKPFYERALNGDLEPFKDFKALLEEIVNERIAAGKSGEVIVVADCADNLSRNEKFDECVYVERWWQETHLEWQKNNQKITVICPHPNSVLNKHSHKERISRQHSLTITALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID3</accession>
    <name>K0IID3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC uptake transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c27590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27590"/>
    <dbReference type="EnsemblBacteria" id="AFU59680">
        <property type="protein sequence ID" value="AFU59680"/>
        <property type="gene ID" value="Ngar_c27590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27590"/>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_2"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2759-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="30089" checksum="12D51DB18CD233D1" modified="2012-11-28" version="1">MRGIRNMVLEILETAFIQRALVTGIAVAVICSAVGFFLVLRRHSLFGDALSHMAFGGIAVGLFTNIYPLWTAIVVSVLAALGMTKLRQSTKVPPDATVAVLLSSGLALGIVLVSISGGFSVDLFSFLFGSILLVSPDEVYIIIGLSAGIMAILLLLYRKFMYIAFDEEQAKVSGLQVSKLNYLFIVLASITVIASIRLVGILLISSLIVIPNITAMLFGKGFRKTAIISGAIAVSSVIAGILISYAANIATGGTIVLVLVMIFLAALVAKKAERTKRLAGIKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE2</accession>
    <name>K0IIE2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08650"/>
    <dbReference type="EnsemblBacteria" id="AFU57807">
        <property type="protein sequence ID" value="AFU57807"/>
        <property type="gene ID" value="Ngar_c08650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08650"/>
    <dbReference type="HOGENOM" id="CLU_157324_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-863-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="10724" checksum="C7071225FA6E8ED6" modified="2012-11-28" version="1">MRFIVRTIFPTEAGNRAVKDPNFTKNIEDFMKNTKAEAAYFTEINGDRTGVFIVDIPSADMIPVIAEPFFLMGAKVEFHPAMVLDDLKKGLSVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL2</accession>
    <name>K0IIL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative subtilase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c28250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28250"/>
    <dbReference type="EnsemblBacteria" id="AFU59745">
        <property type="protein sequence ID" value="AFU59745"/>
        <property type="gene ID" value="Ngar_c28250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2790"/>
    <dbReference type="HOGENOM" id="CLU_003710_0_0_2"/>
    <dbReference type="OMA" id="PWIAFEG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2825-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1523"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="157"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1556" mass="167467" checksum="15CF8B5CC168ADB1" modified="2012-11-28" version="1">MAVPAAYSLPIRESGPLTSLFSKSLPYLKGDDIVTVNGLPVDKNAIKTDFGAIDLGRMEYNGNVGRTLVYGSGNIAALGKSAHVVSFGGSTQQYSQQRLLGVAVSQSPLPQNLGFSYAADSPLQFDYREDQIGSPGRLSGSSIIGSDKVADTYDITGEGVTVAIVDTGTDFSNPDMMHALARDENGVPIMLDADGQGIVLTRATYVAKTDPSGAIVDGDYTEDSPPEGYTSWAYANETGTVFLKTTFGNIPTYNPLYPIFGQPVVNATARVDWIIGRSPTDYIRSASGVYHFGIIYQLQQQFGTLTFGLVPVLVVDSKEPGVYDTIIPDMYSGWYFYTHNELARLAHVEHLFSEPSYDFTDDVPIKLGDGNEFLTYDYNDDGFPDFSAGTAGARVVDLWQVVASSNKTKPVLGEETGYGGVVVADLLEPLDPAGNYFGVMYDIAGHGTGTAATVASKGEQQYNIYDDGTMYGLAGIAPGAKIIPVKALWAGDSLYGWLYSSGFDLGEDGVWRYSGDHKADIISNSWGVASFPLLQYGPGYDVLSVISSLLVVPGLLDDDYPGTLFVNSLGNNGLGYGSVGAPNASPLAISVGATTNNVHVGYNGFENVTRFGNWATYFDDVADFSSRGPGLLGDPKPELMAIGSYAFTPTIVNLKNLKTTADDSNNDGAFALFGGTSMAAPMVAGAAALVIEDMRSQGKEPDPFEIKTILMSSAVDLKNDPFVQGSGRVDALAAIRLAKGENDQLMAYTEDTVPNVLSAMSKSIHSYSDVLGIIEGGQGVAEKKLGAEFRDGRWFAGHISQGGSASAQIVIENPSAEDMEVEVTGAIEKLVSRYQLHNTTRLFEKDPLYSSVDFGYDPNYFSIDEMGGVPDNADLMVARVTFPFESFMNTTEFYADHLRIASVYAYDWSDSNLDGKVSYAETSMINRGGSWGTVQELRISDPNEKFKNTPLIGVYPVPTVFSFWQGDRRINSTAMNYTLTIEFYERQPNPAITLDGAEGDGKLTLNVNSNNKEVVTATIHVAEETLPGIYYSSILIKPAAGESSSSSSSHQIVMPVSYVVTSKPVPKDVPVVVVPDASIGEQDLGLRPNGYVGGLFDMTSRYSAGDWRSYHFMVDDSTITSMTLKISWPHNSTSISAMAFGPDGRMVATSVPSGVFEIFSGWPSNDWLGTTSYSEGGAFYFSQNAGENSTLLHVPVNGTGVYSVLLHNTLFHGNSLYEPLQVEAKFSTILPDGAAPAIGIDLPKYLRAGEHRIPVTITEENLASYEYAIDFGDPVIPDKVIISTGSNNSTFDLVVDTTVLAEGTHRLRIDSMDLVGHTTSFVSTFEVDRTPPVVNIYMQEDAGIRNAENYTIVTARGGALMWNISDNNGIVSPVSITAYDGSKIQSETLSSSFTILNSTLPEGEYLYTIDVQDVAGNRVVQDIRVVIDRTPPATSLSFINANPQDLRDMVTVVLGTDDPNIRSVTLQVGDRKSIDVTGMPEYQLDTTELPDGEYELKLVATDIAGNEGTISMPIIVANAAPRIMSAILVGLAAGGGIASVAWFIIFTRRRASDYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS0</accession>
    <name>K0IIS0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nnrD</name>
        <name evidence="2" type="ordered locus">Ngar_c10650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10650"/>
    <dbReference type="EnsemblBacteria" id="AFU58007">
        <property type="protein sequence ID" value="AFU58007"/>
        <property type="gene ID" value="Ngar_c10650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1010"/>
    <dbReference type="HOGENOM" id="CLU_024853_2_2_2"/>
    <dbReference type="OMA" id="HIPHTNE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="291" mass="30410" checksum="7E05AB3C7EF814A6" modified="2012-11-28" version="1">MPAAIAVTPKLVRQLMPPRSILSRKGDNGIVLVAGGSRFYHGAPVLASMAALRSGADLVYTAVPRSIITAVRSFSPAIIALPLPDDKLTVGSANRLVAMLPKRTDAAAIGMGMSIEPEAIVALIKKLKEAGTKILLDASALIPMVLGEISNTGSIVTPHAGEYRRLFGCDSGTTKDEMTSNVRRQAKEYGVTVALKGWLNVISDGDKVATIRRSTPAMTVGGTGDVLSGLAAGLLAKGMKPFDAAIAAVYLNGVAGSIAFKRSGLHIVATDLLDSLPAAMKPFDRIKQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY8</accession>
    <name>K0IIY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59955">
        <property type="protein sequence ID" value="AFU59955"/>
        <property type="gene ID" value="Ngar_c30390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30390"/>
    <dbReference type="HOGENOM" id="CLU_113595_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3039-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="166" mass="19459" checksum="724B84481CC3F79F" modified="2012-11-28" version="1">MGLKKKRDEEKQKSIERFYALLKALMDELFEYAPKSKHVKMPFNVSYGLIYDDRDSVLFTGVDQKTGKKMYLYNVRVIGRMFEQKRQAMLEDKTTDTLFSWIADVCSLYIHPFVYDHVVNVQHRGEGAAERTTRQIVRGFLEKLTSDPELKYVLDTIRDPAPPDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ21</accession>
    <name>K0IJ21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tthioredoxin reductase</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxB</name>
        <name evidence="4" type="ordered locus">Ngar_c21730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21730"/>
    <dbReference type="EnsemblBacteria" id="AFU59103">
        <property type="protein sequence ID" value="AFU59103"/>
        <property type="gene ID" value="Ngar_c21730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21730"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2151"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_2"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="44"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="349" mass="37889" checksum="384BB89F6168F960" modified="2012-11-28" version="1">MLFTTSLQFMQFEAIPNGLLRGHGIVTLLSENESGSGGNRKHCDVLIIGSGPAGYTAGVYTSRAKLSTLIISGTLPGGQLMTTSEVENYPGFPNGIFGPELMMNMRQQAERFGGVIVDDEVIKVDFKKRPFTITTHSETYTAEAVIVCTGASPRKLGIPAEQQFSGRGVSYCATCDGPFFKGEDIVVVGGGDTALEEATFLTKFGKSVKIVHRRDTLRASKILQEKAMENPKIEFIWNNVVYDIKGDSKVATVMVKNVASGKETTIKAGGLFVAIGHEPNTSIFKGQLELDDKGYVILKEHTKTSVDGVFAAGDVHDHRYRQAVTAAGFGCMAAIDVERWLSERKHIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE9</accession>
    <name>K0IJE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32340"/>
    <dbReference type="EnsemblBacteria" id="AFU60150">
        <property type="protein sequence ID" value="AFU60150"/>
        <property type="gene ID" value="Ngar_c32340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32340"/>
    <dbReference type="HOGENOM" id="CLU_055322_1_2_2"/>
    <dbReference type="OMA" id="YIVASHE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3234-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="193" mass="21280" checksum="BCBABA2E3AC67BDC" modified="2012-11-28" version="1">MKTTFNVLGVAGSTRRGSYSAQALNIALEHAKKQGAEVRLLQAKLPLYDPNAPASKEVEEAAEAVAWADAIILASPDYHGSMSGALKNFLDYFYEEFAGKLFGYIVASHEKGLTVMDQMRTAVRQCYGWSMPYGVSVNGPQDFSGDKIVNSRLSKRVQMMARDLVVYGRLINGQFVRDLGSSEQDTFAAHYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF5</accession>
    <name>K0IJF5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32390"/>
    <dbReference type="EnsemblBacteria" id="AFU60155">
        <property type="protein sequence ID" value="AFU60155"/>
        <property type="gene ID" value="Ngar_c32390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32390"/>
    <dbReference type="HOGENOM" id="CLU_100611_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3239-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="18588" checksum="2B73D3CDAE3968FC" modified="2012-11-28" version="1">MQGHHSSNMKEMHQHQHGGSSSLRWATAKHALRCLIGCNIGEGAGVAIGFLLGWDVTSTLVLAVGLAFAVGYVFTLILMLKTLPLRQAARVTVVGDTASISAMEFTENLLAFTIPGFMMASLTEPIFWLGLSIILPAGYVVSYPAMYWAMKREQRKRAGAQAPIRTTTNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH3</accession>
    <name>K0IJH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59323">
        <property type="protein sequence ID" value="AFU59323"/>
        <property type="gene ID" value="Ngar_c23980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23980"/>
    <dbReference type="HOGENOM" id="CLU_1718273_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2396-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="16825" checksum="5F627B6930B64138" modified="2012-11-28" version="1">MSDEKVVKITKDGSTATYRETAVEKSKDGSTHIMTNDNENLKTKALRAENAVADLVDSALDKATKTIKTKASELSKSGALEPGYAVGRKDSADIGRLGPMVTDLAATFENTITMIRNHPYDEQVRLLTGYKKLLEEQINVIDSRIHFIKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI5</accession>
    <name>K0IJI5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ordered locus">Ngar_c24240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24240"/>
    <dbReference type="EnsemblBacteria" id="AFU59348">
        <property type="protein sequence ID" value="AFU59348"/>
        <property type="gene ID" value="Ngar_c24240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24240"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2394"/>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_2"/>
    <dbReference type="OMA" id="EHAIKYE"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="241"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="535" mass="59503" checksum="F50644D9F03B58E5" modified="2012-11-28" version="1">MLLEDNPKIITTKSMIQLAEMDIKLGRVHHNLSVPLLVELIINRKEGILSSTGALSVKTGRFTGRSPDDKYIVDDEVTHDTVDWGKINHPISEENFDKIFNRMKSHIEDKELFIFDGFVGADPENRLPIRVINNRAWHNLFARQLFIRPTLEELENFKPEFTLLSCDDFAAIPEEVGTRTETFIIINFKKKLVLIGSTSYAGEIKKAMFSIMNFILPRKGVFPMHCSANVGKAGDTALFFGLSGTGKTTLSADPDRQLVGDDEHGWSDAGIFNFEGGCYAKCINLKKEKEPQIWNAIRFGSVMENVVMRDGTREPDFDDGSLTENTRVAYPLDYIDGAVIPSVAGHPKVIIFLTADAFGVMPPIAKLTKEGAMYHFMSGYTSKLAGTERGITEPKETFSQCFGAPFMPLHASKYAAMLGKKMTEHGTRVYLINTGWTGGPYGVGKRMNLAYTRAMVTAALNGEIDRVPVKHHAIFNLDMPTSCPGVPDEVLDPRNTWSDKDSYDAAAKRLAALFVKNFEKFGNVSKEIIEAGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ3</accession>
    <name>K0IJJ3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58447">
        <property type="protein sequence ID" value="AFU58447"/>
        <property type="gene ID" value="Ngar_c15120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15120"/>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1510-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="10214" checksum="BED8B287A79B28A7" modified="2012-11-28" version="1">MDIILQLSQRGELNQSQLMSSCRLNNVQHKPIIDELVEKGLIIRFEEPWGEQNRIIKYKVSEKGREIAKKIFEPYELLFPRSEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ4</accession>
    <name>K0IJJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59363">
        <property type="protein sequence ID" value="AFU59363"/>
        <property type="gene ID" value="Ngar_c24390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24390"/>
    <dbReference type="HOGENOM" id="CLU_3039182_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2437-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="5796" checksum="A3B14CC10E495E75" modified="2012-11-28" version="1">MAFSVVGVMVKIAVGEDDVIITLDTKEKLLAVKRKVAIPKESIVSPSTERAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJV3</accession>
    <name>K0IJV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34700"/>
    <dbReference type="EnsemblBacteria" id="AFU60385">
        <property type="protein sequence ID" value="AFU60385"/>
        <property type="gene ID" value="Ngar_c34700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34700"/>
    <dbReference type="HOGENOM" id="CLU_1387625_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3471-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="21040" checksum="87EEA872F1716E38" modified="2012-11-28" version="1">MVRCYHLTFELTVQDESGATSTDTASVTVKNVDNGGDNSGEDGVNTNSASGLNTRLSAGEGVEEGAEEQDLCKRIPQPPACRLTNNFILPETRITSVKDRNGTHLPVDGSSTPSTISDSITFTFEGEQLDEDKSGQVSFKCRLDRGAVFEPCTSPITYSGLATDHYKGTFVPHTFEVVAIDNSVKKGTIDKFGNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK70</accession>
    <name>K0IK70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59623">
        <property type="protein sequence ID" value="AFU59623"/>
        <property type="gene ID" value="Ngar_c27020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27020"/>
    <dbReference type="HOGENOM" id="CLU_2433966_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2702-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="9832" checksum="192D863C509DD596" modified="2012-11-28" version="1">MIDIAMIPTVKEQGFVMGDVIKSVDELCVARQEAAEGKRPQYILIFIDEINRFVPRRGGSNSASSSVAEQIVRMVITGRSRGTILFSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKB7</accession>
    <name>K0IKB7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 9">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 6 9">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">pgk</name>
        <name evidence="10" type="ordered locus">Ngar_c18700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18700"/>
    <dbReference type="EnsemblBacteria" id="AFU58802">
        <property type="protein sequence ID" value="AFU58802"/>
        <property type="gene ID" value="Ngar_c18700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18700"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1853"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_1_2"/>
    <dbReference type="OMA" id="MGDGYKV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="401" mass="43659" checksum="811F915E270DCF0C" modified="2012-11-28" version="1">MALRTLSDLPDSQFDGKRVLVRVDFNVSVNNGAVGEDYRIRMSIPTIEYLTKRGAKVILASHLGRPEGRDRQYSLAPVAKRLSDIVGGKSRPAIRFADDCVGVEVEDEISKMNKGDVLLLENLRFHKEEELNDPEFSKRLASLADIYVNDAFSTSHRKHSSTYGAAWLFDIRLAGFNLSKEVEYLSMIRENPIKPFKIVVGGVKIKDKIGALEHLLPKADKVMIGGAAAYTFLKAEGIKTGNSLIDEERLPWVTKALSTYGDKIMLPTDHVCANSPNDNSVTMVRGDIPNGMSGFDIGNETIERYSAEVGGNGGGTIFWNGPMGMFEIRAFSNGTINIAKSMALAFWRGSKTLIGGGDTLEAMKKSGVAENEVSHVSTGGGATLRYLAGDEMPGVVILNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF4</accession>
    <name>K0IKF4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58892">
        <property type="protein sequence ID" value="AFU58892"/>
        <property type="gene ID" value="Ngar_c19600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19600"/>
    <dbReference type="HOGENOM" id="CLU_1682756_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1958-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="17345" checksum="BD9094E3CC15220B" modified="2012-11-28" version="1">MPHLVWMVTEEKYWDTESGLFSVWAPICAMHVLSKIGGKEAASAVYSAMRIHYDDTGDWITEDMPYVLAAFGIEGSDTLASMVADARLDEYVRDRAARALVIISGVYPEIKSRSVEVLKKAITDEGDESARSILADTLAEFKDSDTLPFLEDLFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKJ8</accession>
    <name>K0IKJ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20550"/>
    <dbReference type="EnsemblBacteria" id="AFU58987">
        <property type="protein sequence ID" value="AFU58987"/>
        <property type="gene ID" value="Ngar_c20550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20550"/>
    <dbReference type="HOGENOM" id="CLU_1025333_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2053-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="271" mass="30046" checksum="D41A9E11A2C07168" modified="2012-11-28" version="1">MKFGIFVHPKRPKVPVDKILKHIESAGASCSRKDPDVAIVVGGDGTFGYYGRTLSIPMLFVGVRDNSIAGSRARLAEIFYDDLARALHDIEDGRYSVEEKKMISVCLNGHSVDVLTDVYLERGKFAGCLRYATMVKPSDRSKFIHFGDYAIGNGVIVSTSFGAGGYFSYPNRLLPYRQASIGPASFGDNRIGICHIIPTYLVRKRNGTTRQNSRVRYTVPRQSIIEIKLLRDANARLYGTTMHSKGVAVRRGDIITVTPSRRTAKIIRLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKN0</accession>
    <name>K0IKN0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PilT protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29400"/>
    <dbReference type="EnsemblBacteria" id="AFU59858">
        <property type="protein sequence ID" value="AFU59858"/>
        <property type="gene ID" value="Ngar_c29400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29400"/>
    <dbReference type="HOGENOM" id="CLU_121774_1_0_2"/>
    <dbReference type="OMA" id="ASVIVKW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2940-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="16111" checksum="48B47ABB306FE7E5" modified="2012-11-28" version="1">MTGNKIVIDASVIAKWYNNEALTDKALLVLQSFINGRIHLCAPEHLLYEVGNSIWKNKALSTADCMQAMNDLMEMDIEFTRLDPAMASKAMKLARDLSISYYDALYIQLSIDRHMTLLSADVKLISKARGNSNAMHLKDCQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR7</accession>
    <name>K0IKR7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <shortName evidence="4">HK</shortName>
            <shortName evidence="4">HSK</shortName>
            <ecNumber evidence="4">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">thrB</name>
        <name evidence="7" type="ordered locus">Ngar_c21970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21970"/>
    <dbReference type="EnsemblBacteria" id="AFU59127">
        <property type="protein sequence ID" value="AFU59127"/>
        <property type="gene ID" value="Ngar_c21970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2176"/>
    <dbReference type="HOGENOM" id="CLU_041243_1_1_2"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="222"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="316" mass="32918" checksum="C557EDB050BBBE0F" modified="2012-11-28" version="1">MERMARMAAKSRTAVAPCSTANLGPGYDVFGLALDALKDKVVIKASSTAGDRKITIKSSDQAIPAVAESNSAGLVVKSMMRDFHIGDDIEVQVTKGVPAGYGIGSSAASAAAAAIAFNALYNLKIDRNRLVEYAAEGEIASAGIKHYDNVSASLLGGFVIGSKGQFIRIEPPRDLFLVVAVPLSMQVPEKKTEVARSILPKDVPLKSVVHNVSGAATIVAGFALKDVEMIARGIDDVIVEPVRKHLIPGYDSVKQNAMSAGALAVTISGAGPSMIAFLKTCKNANMVAAAMAKGFEEAGVKSRTFVCRPSSGARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKX5</accession>
    <name>K0IKX5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60043">
        <property type="protein sequence ID" value="AFU60043"/>
        <property type="gene ID" value="Ngar_c31270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31270"/>
    <dbReference type="HOGENOM" id="CLU_1965636_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3127-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14270" checksum="31325A45C09B2BE0" modified="2012-11-28" version="1">MIIFPDKKEILDAISSKIKAENAATERLQNRIRETPIEDVRKRLANHLDETYEHQRRLQQLIRNLSGTPTDSKGHLPSLVPPATSLTAKTVKDTVRETVKEAATGGGTDTGSRLTFEEMELMKTKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL29</accession>
    <name>K0IL29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59287">
        <property type="protein sequence ID" value="AFU59287"/>
        <property type="gene ID" value="Ngar_c23620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23620"/>
    <dbReference type="HOGENOM" id="CLU_2461866_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2360-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="9565" checksum="47CF4903F5E12AA0" modified="2012-11-28" version="1">MKEMFASNILVLVALPFAAFKIRKTISILLQGPVLIDNDDYMITVSIVAIDDMNQPLPPSDNFLLPSANATSNILVPFNGGEDTITTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL40</accession>
    <name>K0IL40_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ecr</name>
        <name evidence="3" type="synonym">rrp4</name>
        <name evidence="6" type="ordered locus">Ngar_c23870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23870"/>
    <dbReference type="EnsemblBacteria" id="AFU59312">
        <property type="protein sequence ID" value="AFU59312"/>
        <property type="gene ID" value="Ngar_c23870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2359"/>
    <dbReference type="HOGENOM" id="CLU_071769_0_0_2"/>
    <dbReference type="OMA" id="GPYIPEV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="263" mass="29006" checksum="87D30CB3103B96B0" modified="2012-11-28" version="1">MRRRYVIPGDKIAEGNFRPLMNVIKAGNALIATRIGIAETGRDGVKVIPLSGVYIPRVNDLVIGKVIDHSSLSWEVDINSCFSAHLPAQDVFGRDFSPARDDMSRHFAIGDMITARIMAFDRTRDPMLTVQDRDLGKIPRGEVLKISATRVPRLIGKRGSMIQTIEQATQTRVLIGQNGIVVVTGRTPEGIKLAVRAIKMVEEEAHTANLTQRIKVLLNVPDTPPQQQQETSLRSPVGGASQPEQIESTIDEVEEELEVEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL82</accession>
    <name>K0IL82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24380"/>
    <dbReference type="EnsemblBacteria" id="AFU59362">
        <property type="protein sequence ID" value="AFU59362"/>
        <property type="gene ID" value="Ngar_c24380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2409"/>
    <dbReference type="HOGENOM" id="CLU_074748_0_0_2"/>
    <dbReference type="OMA" id="YAWAFPL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2436-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="340" mass="39036" checksum="4754A6C697C1C616" modified="2012-11-28" version="1">MKIAVVGIGVAGAYLMNRLSDDHDNQVVGFERMPQDQHDAVCAWATCENVMAGLAKNCGLNFDDYVLHDGQHMIVDLGSKDSVDIKLRGMVSYDKLRLIQDMIKGTEIKFGRAPRKDELEPDFDIIIDSTGFHRNYLPRVGNEMWIPCVQYKVRYQPGKEPFDDFYLKSFPSMSGYFWYFPLGNGYAHIGAGDFMKNHNHFVDEFLNKYDCEVIKKVGRPVRLTPPASCEPFTDGKKSVGVGESIGTVYPLLGEGIIPSTWCAELFIRNMHDMRAYREAVLEKFKIYSLVFKFIQLKIAGKFRMVRHGMDMLKIYQHMKSEEERYGMEVRMADMLKVSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD5</accession>
    <name>K0ILD5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">thrS</name>
        <name evidence="12" type="ordered locus">Ngar_c34230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34230"/>
    <dbReference type="EnsemblBacteria" id="AFU60338">
        <property type="protein sequence ID" value="AFU60338"/>
        <property type="gene ID" value="Ngar_c34230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3419"/>
    <dbReference type="HOGENOM" id="CLU_029833_0_0_2"/>
    <dbReference type="OMA" id="DAHIFML"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="206"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU60338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="629" mass="72189" checksum="6FF3D8CA24898485" modified="2012-11-28" version="1">MRLLQLHSDFIEYEPIEKEIRDAEDITSKSKVRLEDLVVAFVAVENGDDESIAKAAVDEIKKYLDTVKSGRLLVYPYAHLSSDLAPPGVAAGIIKSVESFAKGSSIGQVYRAPFGWTKSFNIKVKGHPLAENAKEISRQADHEHVGHSHGEKESTALKAEEKLQSFWFILQPGGTMTPMSEYRFKKQDQNLQVLANYEMAKKRTVDEQPAHVRLMKKLAIADYEPASDAGNMRYYPKGRLMKSLIEQYVTRRVMEYGGIEVETPIMYDTKHPSMESYFNRFPARQYNITSDSKQLFLRFAACFGQFLMAKDFNISYKHLPVKLYELTRYSFRREKSGELVGLRRLRAFTMPDCHALCRDLDQAKQEFRKRFELSISVLQALGLSTEDVEMAIRFTEDFYNENKEFITELIDRFGKPVIAEMWKERFFYFTLKWEFNYVDGLGKASALSTDQIDVENGKRYNIEFVEEDGSKKNPIILHNSPSGAVERVMYALLEKAANVSKAGGIPSFPLWLSHTQVRVIPVGKEHTEYCEKVLAELSANQIRADIDDRDETVGKKIRESETEWIRYTVVIGDKEISAGKLVVRDRNEGKQREMTLQELVDEVKAQTKDKPYLPLNLPTHLSTRPQIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG0</accession>
    <name>K0ILG0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">tal</name>
        <name evidence="10" type="ordered locus">Ngar_c34790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34790"/>
    <dbReference type="EnsemblBacteria" id="AFU60393">
        <property type="protein sequence ID" value="AFU60393"/>
        <property type="gene ID" value="Ngar_c34790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34790"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3480"/>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_2"/>
    <dbReference type="OMA" id="VRHPMHV"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="232" mass="25253" checksum="F896B7EA74DFDA47" modified="2012-11-28" version="1">MKQGVGVGNNKMKIFLDTANIESIKKYNDMGLVDGITTNPTLLSKEKGNPAEIMRQVVKIVKGPVSLEVVGTTTAEMIEEAHRLKKYGQNVVVKIPMIPDGLKAVKKLKEEGIETNVTLIFSANQAILAAKAGAAYVSPFIGRLDDAGQEGMAIIREIVQIFKNYQFDTNVLVASVRHPLHVIEAGKIGAQVVTLPPDILGKMLAHPLTDKGLSAFLSDWEKVKRENPNLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR9</accession>
    <name>K0ILR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03260</name>
        <name evidence="2" type="ordered locus">Ngar_c03550</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57274">
        <property type="protein sequence ID" value="AFU57274"/>
        <property type="gene ID" value="Ngar_c03260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57303">
        <property type="protein sequence ID" value="AFU57303"/>
        <property type="gene ID" value="Ngar_c03550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03260"/>
    <dbReference type="KEGG" id="nga:Ngar_c03550"/>
    <dbReference type="HOGENOM" id="CLU_2613745_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-326-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8787" checksum="9CD50B42FCCA632E" modified="2012-11-28" version="1">MADKAEYAFKYLRSEMEKAAAAVGKKPTLQEKMLFAAFENALPLILDIAPDESKVWLKRIFNLVGYVAGYWDTPSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU3</accession>
    <name>K0ILU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59672">
        <property type="protein sequence ID" value="AFU59672"/>
        <property type="gene ID" value="Ngar_c27510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27510"/>
    <dbReference type="HOGENOM" id="CLU_2695896_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2751-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8003" checksum="E543D341FD17CC95" modified="2012-11-28" version="1">MNERMKSLADTLDGTVKKAEAARDSVVTSIEDIGKKADVITTQYARSNAAIVFGPLARSLYGEKVVQRKCVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV0</accession>
    <name>K0ILV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27710"/>
    <dbReference type="EnsemblBacteria" id="AFU59692">
        <property type="protein sequence ID" value="AFU59692"/>
        <property type="gene ID" value="Ngar_c27710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27710"/>
    <dbReference type="HOGENOM" id="CLU_2115558_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2771-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="13352" checksum="7C4CCB745C93AAE5" modified="2012-11-28" version="1">MKNKHVRYKQEYADAEIPHDIKTGGGPAVLRMSFPYLLEWKNKHPFKNDPKAPLFYNMKSGRTLEAIHLILIIFGVLEHPKTHRPARKLTSYQYAIWKDSAKYRLVIKSQKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV2</accession>
    <name>K0ILV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59697">
        <property type="protein sequence ID" value="AFU59697"/>
        <property type="gene ID" value="Ngar_c27760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27760"/>
    <dbReference type="HOGENOM" id="CLU_2550387_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2776-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9813" checksum="2CC29AE59825CBC9" modified="2012-11-28" version="1">MSNPITYRYQLTCFHESKYISTRQVPENGEVPWHEGDSWHVLTGFDLEYKYKQALEELQDKTGMSERKIIETIMCERLQELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM15</accession>
    <name>K0IM15_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative digeranylgeranylglyceryl phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c29690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29690"/>
    <dbReference type="EnsemblBacteria" id="AFU59887">
        <property type="protein sequence ID" value="AFU59887"/>
        <property type="gene ID" value="Ngar_c29690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29690"/>
    <dbReference type="HOGENOM" id="CLU_862226_0_0_2"/>
    <dbReference type="OMA" id="WFYSHKL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2969-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="329" mass="35904" checksum="CCACF3AE6E46A148" modified="2012-11-28" version="1">MWFPISAKREAKSPVHGSSHKSNLNNNCSLGRQLHPIVGLVLVYAKLFLGYVKARSNVYIFPVASLISLLIGSHGNPDPLIALLAATSCYLCALATYVYNDITDVQVDKINRTNRPSITRSNIKGELVKLVTILYACSLALAVFINIPAFLIVTTCTIMGIIYSHPKLNLKEKFPFKTVLTAMGAGLSSLYGGVAIQAGIFSLPVIYASLSFFAFFFILGPLGDIGDLRGDRVVGRRTFPIVIGMAPTLAMMFSVPAAIIASITILYCLYSGSINMVGFMTVIATCFTTLALLFIICKKLDQVSQIRSTRHRMRILHVSLQLSLLLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM56</accession>
    <name>K0IM56_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60017">
        <property type="protein sequence ID" value="AFU60017"/>
        <property type="gene ID" value="Ngar_c31010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31010"/>
    <dbReference type="HOGENOM" id="CLU_2420149_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3101-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10454" checksum="720BD5E8EF868B5C" modified="2012-11-28" version="1">MTKTGRSSNSKSYNPYSLWRALVSMSEPETVASDFICYVCGAVFTTEQDRRQHLEKELAGKAHDETTSKDIEIAKEQTELSETRRQPYEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ6</accession>
    <name>K0IMJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60347">
        <property type="protein sequence ID" value="AFU60347"/>
        <property type="gene ID" value="Ngar_c34320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34320"/>
    <dbReference type="HOGENOM" id="CLU_2204196_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3433-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="12052" checksum="FFD19C1D55281792" modified="2012-11-28" version="1">MDRLSELVERAKAIVAIDPPDRASMWRAYVALEYAVMDLKLRYNLEGEVPSPPKSAKKAIDIAEARSMLGRIDLSSSDRKKLLRDLRSCRDVVKALVASYSRRSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR7</accession>
    <name>K0IMR7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58129">
        <property type="protein sequence ID" value="AFU58129"/>
        <property type="gene ID" value="Ngar_c11890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11890"/>
    <dbReference type="HOGENOM" id="CLU_1178160_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1187-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="27065" checksum="23276139BDBF1354" modified="2012-11-28" version="1">MALEDRKKRKGQTASTIAEAERMVSDQVPPNRREEMLEYLKLFGYKPERTILQVHIVGFFNKRRVGARAVEKRQATAKRYGGTTFVVVGRTHDPSIMDLVIKPRKKPEQTSPGYVGYLWKNKDPQNRPPHEILPLDFTPTHVPYPQDWKNMFATKGFMIALHVPASFAKDKNRLSRALYQAGKNADVKQRWDFIDQIRSAGYGQEQDPLNILKIRLAKGEISQTEYEKLRQTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU7</accession>
    <name>K0IMU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c13060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58244">
        <property type="protein sequence ID" value="AFU58244"/>
        <property type="gene ID" value="Ngar_c13060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13060"/>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_2"/>
    <dbReference type="OMA" id="GIWAIKW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1304-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="213"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="287" mass="31573" checksum="763908DE5A48BA79" modified="2012-11-28" version="1">MDKSRAFEEAKRAAWVSIWTLVGIGVGEVLVSGFTGSLTLFADGLDSMADALVSFIVWFGIRMLQKPKSRLFHFGYAKIESLAAFIAAVVILILASFIVYHAYENILHPVPVQNAEITMIALAAAGGISLHRAFKVSKVAKKYSLVSLNLDAKNSIKDGTASFVGLGSIIAAYFGIPYMDSVGSILIAVYIFFMAFTAFKESTLVLIDGVKNPELQQEIATHIEKKFNVKVEKILLRPLGHEFSAQVHVELDRNMTLDKAHETLTRIRNSLIEDFKAEDPVVIPKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV1</accession>
    <name>K0IMV1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58264">
        <property type="protein sequence ID" value="AFU58264"/>
        <property type="gene ID" value="Ngar_c13260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13260"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1324-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15253" checksum="C3255CFF88110546" modified="2012-11-28" version="1">MGESKDDFLESFCKGVLEKDHFIRFAGISNHFGHLIATAYRKDLVPLMTHEETARYAVQAAIRAATRETFETKIGELQFSISRYGRLVRATIPIKSSGKNKFLLLLSFDVDAEADSIINKKILPYIAENKDYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX7</accession>
    <name>K0IMX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-citramalate synthase</fullName>
            <ecNumber evidence="2">2.3.1.182</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cimA</name>
        <name evidence="2" type="ordered locus">Ngar_c14580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14580"/>
    <dbReference type="EnsemblBacteria" id="AFU58394">
        <property type="protein sequence ID" value="AFU58394"/>
        <property type="gene ID" value="Ngar_c14580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1422"/>
    <dbReference type="HOGENOM" id="CLU_022158_4_2_2"/>
    <dbReference type="OMA" id="DWSNGMR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="406" mass="44916" checksum="75FFCD6D2DCC2460" modified="2012-11-28" version="1">MSLKSDDPNYYAHQYNWMGENGKQKKIRILDSTLREGEQHPGVAFTIKQRIQIAWMLDSFGVDQIEISPVVSPDHAEATKTIIKQGLRADIVAHTRAIKSDVDVAIDCGATWVATYMGISDIHISAKLKITREEAKARALEVADYIKAHGLKARFTMEDASRTDPTFLIEMCKEMNRRGIERISIPDTVGIMRPRGMYNLVKMVYNNIDKSKTSLDVHCHNDVGLALANALAGCEAGADQIHTTIDGFGERTGIPSLAETAVALTLIYKSNNDLRLHMLKDLSKTISDYISLPIPESKPIVGDSAYKHKAGTHLAAILRNPAAYEIIEPKTVGNRRKIVFGELAGKNGAAYLLSLLGLETSKHEAEALARGLKELRMGDILELYLDDRLERKILNDAAVKLSPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ8</accession>
    <name>K0IMZ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58499">
        <property type="protein sequence ID" value="AFU58499"/>
        <property type="gene ID" value="Ngar_c15660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15660"/>
    <dbReference type="HOGENOM" id="CLU_2930312_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1564-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="7035" checksum="F6AFF6463BD6796C" modified="2012-11-28" version="1">MFEQLKLYYHSVMFAWSLRRFYSSIGDMMNHAMAMGEAMSRDQKIDQTLGSVKGKIKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN41</accession>
    <name>K0IN41_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps15p</name>
        <name evidence="3" type="synonym">rps15</name>
        <name evidence="7" type="ordered locus">Ngar_c17810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17810"/>
    <dbReference type="EnsemblBacteria" id="AFU58714">
        <property type="protein sequence ID" value="AFU58714"/>
        <property type="gene ID" value="Ngar_c17810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17810"/>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_2"/>
    <dbReference type="OMA" id="EEHPKDM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16844" checksum="5F75C6BED8F142D3" modified="2012-11-28" version="1">MARIHVHTHGKSHSTRPTSKSSPSWLNQSRDQVSSLVVKLSKDGLSPSEIGLKLRDEHRIPLVKPVLGKSLTEVLAENNIKPDMPEDLDKLVKKALGLQKHLKVHNSDHRNVRSLELVEAKIHRLSKYYKSIGKLPKNWKYAAVIAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN50</accession>
    <name>K0IN50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58759">
        <property type="protein sequence ID" value="AFU58759"/>
        <property type="gene ID" value="Ngar_c18260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18260"/>
    <dbReference type="HOGENOM" id="CLU_3094229_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1824-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5795" checksum="2C6863217AC62135" modified="2012-11-28" version="1">MKDATTLALDHEIDTLGWMWIKIDATIKRNASGVSDDIVKRMYGSQIAHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN64</accession>
    <name>K0IN64_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase IV</fullName>
            <shortName evidence="1">Pol IV</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dbh2</name>
        <name evidence="1" type="synonym">dbh</name>
        <name evidence="3" type="ordered locus">Ngar_c18970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18970"/>
    <dbReference type="EnsemblBacteria" id="AFU58829">
        <property type="protein sequence ID" value="AFU58829"/>
        <property type="gene ID" value="Ngar_c18970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1881"/>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="1 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="14"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="378" mass="41393" checksum="27B38655EEDF26BC" modified="2012-11-28" version="1">MIIEGPKSNTSRIITHVDFDYFFAQCEEIRRPELRSKPVVVCVFSGRTEDSGVVSTANYVARKYGVKSGIPIRVAKSKLAEVSDAVFLPLDSAYYSQVSESAMSIISSYADMFEHVGIDECYLDVSQRAAGSFDVAKGLAQNIKQDVKKQASLTCSVGVAPNKMLAKIASDLHKPDGLTVIEPDDAARFIAGMDVGRIPGVGPKTCERLGELGIKTIGDLAKFDLFRLIEEFGKKNATYMHNASKGIDDEPVVESGEKQQIMRIATLKSDATSSSEMLGDLYEICRSVFQTATDRRLSFKTVGVLLILDNLDNITRSKSLKVHSTNFESLHSAARSALDETMREAGPVKVRRLGVRLSDLQSSEGQNTMLDFMSSGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ1</accession>
    <name>K0INQ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cax</name>
        <name evidence="7" type="ordered locus">Ngar_c28440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28440"/>
    <dbReference type="EnsemblBacteria" id="AFU59764">
        <property type="protein sequence ID" value="AFU59764"/>
        <property type="gene ID" value="Ngar_c28440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28440"/>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_2"/>
    <dbReference type="OMA" id="AAVMITC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="223"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="369" mass="38832" checksum="459713360F526018" modified="2012-11-28" version="1">MLKSVKISKSSAIYFLLIFVPIAIALEFVHADHIVLFIIAAIALIPLAKLIGDSTEHLATHYGATTGSLLNVTFGNAAEIIIAVVAINAGLLDLVKASITGAIIGNILLIFGLSVVAGGFRFKEQRFSRENIGIQSSMLLIAIIGLAVPTILTATVLSGAENEGSVQLLSDSLAIILIIVYALGIVFTFFTHKHLFVTPEEPTTAEGAHQEDVHVGHWSKKKSFLLLAASMAGVIVVSEILVASVEQTGEELGFGELFVGAIIVGIVGNAAEHSSAILLARKGKIDLSIGIAAGSGTQIALFVVPILVFAGIALGQPFTLVFTLLELAVLFLAAIILNLIVHDGRSNWFEGVMLTAVYIIIAIAFFFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR6</accession>
    <name>K0INR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29200"/>
    <dbReference type="EnsemblBacteria" id="AFU59839">
        <property type="protein sequence ID" value="AFU59839"/>
        <property type="gene ID" value="Ngar_c29200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29200"/>
    <dbReference type="HOGENOM" id="CLU_840962_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2920-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="330" mass="38848" checksum="B3485D6751765EF3" modified="2012-11-28" version="1">MKRSKEWKRMILDTVIRISPTLENRVGARSWCYILENEGVITKGDFDDAEKFITECRKNGKLPVDFTAEYNERIFEGVEEPEQVTVEDYFVEMVRNVWNNAHNWYSPDWWEGEKYYLQLLVEKLDLKNLFMPICKEYHIPVANGKGWSDINQRYDLIKRCMWAESRGLTPIILYAGDFDPYGKHISDTLIENIHQLDGLLDINGNRINISMHRNQIKRFCLNKDFIDRHNLTWIDNLLSGSGKDMSKPNKNGKIKRFIQEWIDTVGKRKCEAEAAMKVPKEARQLFEQNIQGYLGRNAKERFESKRAEIEKRLLAFKERKGIANFPDTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS2</accession>
    <name>K0INS2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59869">
        <property type="protein sequence ID" value="AFU59869"/>
        <property type="gene ID" value="Ngar_c29510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29510"/>
    <dbReference type="HOGENOM" id="CLU_025554_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2951-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="595" mass="64023" checksum="A01A677E7A840C98" modified="2012-11-28" version="1">MPSQNTTSADAVASNATITATDTSPGAATALVTISGEPLVHTDGKIVRSFSYPLLKFNGETAAELAVTITWDTDGTTKVEDNRGYSYTISIPESQDVFSLWYNSTHVDQRVVGPELQYDVYWTVVEGENGYVDKYKYTIAGTSINGSLISFGVDGGKYDKIEHDRFFVEQPASVDNIDALTLDPALDCTAPANDIQDDNLNREGTNVVEDGLELDWKDAIASGHNVYVDSAKSSISIPVGKLFVIDPTVVSSATNSMSPFGNSTFEGETRIVTIGGRLNVFYYDGSNIVYRTPNDGGKTWSTPISTGSGALASDRYRWSIITTVYSNTTYASLLYWTPAGSNMNFYALRGAANGADISWSSPILLGYTSSNSGTCGSGGACAAVAVATDTNGYIYAAFGYLSGGSTTYSYQIMRSADGGLTWSVSLPQVNNISSNRFAMALTMLNSSKMLFAYTTSSSSNIFYRVYGGSAWGSEQTLSGTDLTGATFKHLSAATDSSLSAYLAYTNVTSTNGGILKVARFNATGHFELIETADSTLRNRLPNIMFRDNGFTDGDLDIYSLADGKFMILEREADRTGNNHSILLEQRSPHLTNLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS6</accession>
    <name>K0INS6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59889">
        <property type="protein sequence ID" value="AFU59889"/>
        <property type="gene ID" value="Ngar_c29710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29710"/>
    <dbReference type="HOGENOM" id="CLU_094092_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2971-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="268" mass="30248" checksum="3848B6E8432F7B8A" modified="2012-11-28" version="1">MSLDYSLLVIDGGISRSAADDASVNPVLYDHMIDYLSKGYAVIYITSNQAKAIQKMKAKTGLDIEEYIERRALILIDPKLVFCRSGNLTSSACEILRSLRSIMQKTISKHSRIVIIYSVNDLPVHEKCDDVGELTYERLIPSKICHKGRIEIICCYDSRSFESLSLGKTISVLGLYSYTIHSNWHYCEWHPEIIIELIAEGLNRALGQGAAQLIFTSLKWIYRIDEDSIISQPEVFEEKLRRVLGGKADIAIRVILDEIRSRVAFSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT6</accession>
    <name>K0INT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59939">
        <property type="protein sequence ID" value="AFU59939"/>
        <property type="gene ID" value="Ngar_c30230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30230"/>
    <dbReference type="HOGENOM" id="CLU_2550069_0_0_2"/>
    <dbReference type="OMA" id="TFWGYYA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3023-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10704" checksum="C5C6D52ACC467B36" modified="2012-11-28" version="1">MAGILNDNGVIINYMIEAEDAVRVVDTVAKNLMGVSNNRSNFERLPDTFWGYYARGHDGKGRFAVIVTYSENAGDVDELIKMYEQWVAKSKKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW1</accession>
    <name>K0INW1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyanate lyase</fullName>
            <ecNumber evidence="4">4.2.1.104</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cynS</name>
        <name evidence="4" type="ordered locus">Ngar_c31480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60064">
        <property type="protein sequence ID" value="AFU60064"/>
        <property type="gene ID" value="Ngar_c31480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3126"/>
    <dbReference type="HOGENOM" id="CLU_103452_1_0_2"/>
    <dbReference type="OMA" id="YELVMIN"/>
    <dbReference type="BRENDA" id="4.2.1.104">
        <property type="organism ID" value="15984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009439">
        <property type="term" value="P:cyanate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="PTHR34186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="SSF55234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate_lyase" evidence="3">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="18246" checksum="9BCEA6AEA4EFD766" modified="2012-11-28" version="1">MTTTELVPPQSEREAILAAVRSKMREKGLNYTKLAETIGKDPMFVAAALHGQQKLNHADIDKVTSLLGLDGAARKELAVYPNRRNFPATIDPFNYRLLEIIGVYGDAMREMFNELFSDKTGRGGDGIMSAIDFSIKMEKITGSHGEPRCRITLDGKYLEYKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX2</accession>
    <name>K0INX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60119">
        <property type="protein sequence ID" value="AFU60119"/>
        <property type="gene ID" value="Ngar_c32030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3188"/>
    <dbReference type="HOGENOM" id="CLU_044955_0_0_2"/>
    <dbReference type="OMA" id="WEYTCVN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3203-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="388" mass="42891" checksum="71215504D1D6AEB2" modified="2012-11-28" version="1">MNTDNLSALAVGVGVVALIAGFGVYFNNPDLNKAASGQQKNFVPAAIIENGTVTEVQIDKSQFKLAPELAQISGYINTDLVTLADLRGKVVLIDFWTYSCINCIRTIPYLNAWYEKYADDGLVIVGVHTPEFEFEKDYDNVKAAVEKFGIKYPVAQDNDKGTWKAYENRYWPRKYLVDNEGYIRYDHIGEGSYAETEKVIQSLLLERAAYMGITNTTTPLDQSISNPKNAQSVNFGRIDTPELYFGYQFARAPLGNPEGFRPDQTVKYTIPEDTTTILPNRIYLDGGWKNNADHMELQSETGRVVLSYSAKAVNIVAGGSSGSVLYISEDGSSLTGSSSRGADVSEDGTIAIDGQKLYNLAMHENYGKHQLVINVKGKGFEIYTFTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP04</accession>
    <name>K0IP04_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60279">
        <property type="protein sequence ID" value="AFU60279"/>
        <property type="gene ID" value="Ngar_c33640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33640"/>
    <dbReference type="HOGENOM" id="CLU_132458_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3364-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="18873" checksum="55B8B7091AF2E6A5" modified="2012-11-28" version="1">MRTIANKAAASTLTFQNGAILWKNVVGRMNIYLLILGARLYCMAGATETITIRYKNNLPLVSMGIIDAGSNKKIVIDAHLDFASSKTIIPTYIANEMNLSYAGSDETVTGAGIIHIPYYEVSIEIFGRLYDGVHVGCLDLPERTPTTALLGRDLLDNFRICLDGRKKEITVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6X5</accession>
    <name>K0I6X5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase type II</fullName>
            <ecNumber evidence="2">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00660"/>
    <dbReference type="EnsemblBacteria" id="AFU57016">
        <property type="protein sequence ID" value="AFU57016"/>
        <property type="gene ID" value="Ngar_c00660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00660"/>
    <dbReference type="HOGENOM" id="CLU_035527_4_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-66-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="1">
        <location>
            <begin position="37"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="17366" checksum="D7E29F3397D0041F" modified="2012-11-28" version="1">MQPSQISLTYWSVVQQCTSLNTFKNFGLGKVASVTTTIKEEKRPWGRFERFTLNEQCTVKLVYVDGDKRLSLQYHNNHSEFWKVVKGPVKVQVGRSKETLETKSLQTGDTITIPRKAIHRLIGAGTDAIILEISTGEFDESDIVRLEDDYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0I736</accession>
    <name>K0I736_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c01310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57081">
        <property type="protein sequence ID" value="AFU57081"/>
        <property type="gene ID" value="Ngar_c01310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01310"/>
    <dbReference type="HOGENOM" id="CLU_104051_0_0_2"/>
    <dbReference type="OMA" id="IGWIAMP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-131-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17540" checksum="8C55D85D3EFA72C8" modified="2012-11-28" version="1">MSEASSGSSQQPTEIVLASWGTRFLAWLIDFIIVNVVLWAIFAAAAIPFWLTGMPDRWFGRAEGPIEWAVTSLVFFAYWTYFETTTGQSLGKMVMHIKTTDLAGNKVDPRNAAIQSFGKAFLLPIDVILGWIFTNDKRQRIFARAANTIVVKMTGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0I743</accession>
    <name>K0I743_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase of the metallo-beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01360"/>
    <dbReference type="EnsemblBacteria" id="AFU57086">
        <property type="protein sequence ID" value="AFU57086"/>
        <property type="gene ID" value="Ngar_c01360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01360"/>
    <dbReference type="HOGENOM" id="CLU_1954728_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-136-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14637" checksum="2110D8F0EA3D3F3C" modified="2012-11-28" version="1">MLDFGKGFFRRARFFEEYLKPRSANGLVDFIEMGLIPDVEGIYREDLLEMAGRKAGSPTVDAVLVSHAHADHVDYISFLHHDIPLYMGARATPYSRQYRRGRPATLSAKCLIFCQSRQREGPSQSQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7Y4</accession>
    <name>K0I7Y4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57381">
        <property type="protein sequence ID" value="AFU57381"/>
        <property type="gene ID" value="Ngar_c04340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04340"/>
    <dbReference type="HOGENOM" id="CLU_2565854_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-433-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9400" checksum="413F7A56C4DAB3D7" modified="2012-11-28" version="1">MTFEETERYALFATIRHSTRQVWESKIGKVKYALTRYELLIRVTVPLANNHLLLLSFDADTKNVDSIMMDKVIPAIEESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8G9</accession>
    <name>K0I8G9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57571">
        <property type="protein sequence ID" value="AFU57571"/>
        <property type="gene ID" value="Ngar_c06280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06280"/>
    <dbReference type="HOGENOM" id="CLU_2490565_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-626-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9912" checksum="3CCA9BED3EAE5E1F" modified="2012-11-28" version="1">MRFALLYSETVSSGQLLFKHLAAYLIVNTFQLIIYVTYEEEERKTTDKLQLKLLSKEKLQGTDIMTFRLARGPLDYAAGQYVRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA63</accession>
    <name>K0IA63_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58196">
        <property type="protein sequence ID" value="AFU58196"/>
        <property type="gene ID" value="Ngar_c12560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12560"/>
    <dbReference type="HOGENOM" id="CLU_2140090_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1254-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11163" checksum="46CF50D00CD1D6D8" modified="2012-11-28" version="1">MAEAHENGYSIHFAHYAGKLEQHLRKNGISCHDADLIIEESSVLYFEKLYSSGSKISKLLKRYDPAQIFAESATKAIERHLPEAKDTFGSYSEIANCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAC8</accession>
    <name>K0IAC8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58276">
        <property type="protein sequence ID" value="AFU58276"/>
        <property type="gene ID" value="Ngar_c13380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13380"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="OMA" id="HEVCYCA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1336-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="18904" checksum="1B90BFF3F89316E8" modified="2012-11-28" version="1">MKILIAEDEQDILLQYKLALEDKDHHVVTTANGEECLNVYMKELQKQAMPFDAVVLDHRMPKMDGMEVAKRILAANPRQRIIFASAYVNETLVDSVKQLKQIVELLQKPFELDTLVDLLEDKGIYEQLAQLNVKIKEIKNLNPTHDQVRDLLEGLNRLHMSKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAI0</accession>
    <name>K0IAI0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13840"/>
    <dbReference type="EnsemblBacteria" id="AFU58321">
        <property type="protein sequence ID" value="AFU58321"/>
        <property type="gene ID" value="Ngar_c13840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13840"/>
    <dbReference type="HOGENOM" id="CLU_107015_0_0_2"/>
    <dbReference type="OMA" id="AVDCKHW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1382-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="213" mass="23432" checksum="30B172A0E5FE7D1F" modified="2012-11-28" version="1">MYPDLLVRALAAIEPKTTVQRFQAASGIASQSVTKSVLDFLASNNIGTIAKDKVEFSESDRLYAAMLALQSGCDVEQVSAHLSWKDFEKLASEVLRSLGYRTQTNIYLAKPRMEIDVVGISSAFAIAVDCKHWKRSSSLSAISGFARKQAARAERLLTWDRSRITISQVVPVIMTLHAASVKFVHGVPVVPVHKFKSFVMDVKGFLPEIYVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB54</accession>
    <name>K0IB54_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c16230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16230"/>
    <dbReference type="REBASE" id="55355">
        <property type="entry name" value="M.Nga92ORF16230P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58556">
        <property type="protein sequence ID" value="AFU58556"/>
        <property type="gene ID" value="Ngar_c16230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16230"/>
    <dbReference type="HOGENOM" id="CLU_024927_2_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1621-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="292" mass="33765" checksum="F62A039EEF7A23D4" modified="2012-11-28" version="1">MLAQEEEIVNQIVLGNCKDVLRRLPENFVQLTITSPPYRNAIDYDMHASGNGGYYRGKLNLDTNDYLNDMADIFGDKVYRVTKEGGYCCIVIANEVVNGTILPLPHMLLSRLVQPFGKWNLHEEIIWHKVTGGTNRYGSFVINPYPKYYRANIMHEFILILRKGDVNSGRTQRKNALPATHEEWTKEIANSVWHIAPVPPGYINHPCPYPEEIPYRLMKLYSYENDVVLDPFNGSGQTTKVAHHFGRRYIGIDLVKDYVNLARSRMEREPLHIRDEALIANWKKIPSHYKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBD1</accession>
    <name>K0IBD1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58606">
        <property type="protein sequence ID" value="AFU58606"/>
        <property type="gene ID" value="Ngar_c16730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16730"/>
    <dbReference type="HOGENOM" id="CLU_2748320_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1671-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7870" checksum="8270687A5F5C536A" modified="2012-11-28" version="1">MAAAETGIHNNKAKKSARSDAANVEYVVDCILLFYHHRKNHVNWTGDQVGELDPDCQFCKPHMELKTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBV2</accession>
    <name>K0IBV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00800"/>
    <dbReference type="EnsemblBacteria" id="AFU57030">
        <property type="protein sequence ID" value="AFU57030"/>
        <property type="gene ID" value="Ngar_c00800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00800"/>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OMA" id="ASKPIHP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-80-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14707" checksum="E1C0EC5108E3F9A5" modified="2012-11-28" version="1">MAILCADTDFLIDLKDQDEKAIRKMEQLESRGDTVSTTSVNVAEFYFGAYRAKDKATALDQADRLLETFPALPLDFAAARLYGQLSEKLKSNIIEPLDLLIASIVIANRQTLLTRNIKHFEMVPGLTVESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBY4</accession>
    <name>K0IBY4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcription elongation factor NusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18890"/>
    <dbReference type="EnsemblBacteria" id="AFU58821">
        <property type="protein sequence ID" value="AFU58821"/>
        <property type="gene ID" value="Ngar_c18890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18890"/>
    <dbReference type="HOGENOM" id="CLU_132460_1_0_2"/>
    <dbReference type="OMA" id="MKAPICE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1887-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="19279" checksum="B6C782A20DAF11D2" modified="2012-11-28" version="1">MKSAICPFDAKSGVLCSKCESKLESGSITRDDVEAAIKLARLADRNQDVDKFTLVRGAKVDDDFVLVLRSPDVIALQRDSELADKIEDAFGQKVWFVESESSERRFIEGLLRPLKVLSVNLFWLPDGNKLTKVIVAGDSRKAWVNIEKVQKIAKTVRNIELLIEFENNNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBY9</accession>
    <name>K0IBY9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="10">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaB1</name>
        <name evidence="10" type="synonym">ctaB</name>
        <name evidence="11" type="ordered locus">Ngar_c01150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cell membrane</location>
            <topology evidence="3 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01150"/>
    <dbReference type="EnsemblBacteria" id="AFU57065">
        <property type="protein sequence ID" value="AFU57065"/>
        <property type="gene ID" value="Ngar_c01150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.119"/>
    <dbReference type="HOGENOM" id="CLU_029631_0_1_2"/>
    <dbReference type="OMA" id="PPLMGYC"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="297" mass="32650" checksum="97B082308A8C6E58" modified="2012-11-28" version="1">MTTHQITVGSRLKNYYELTKPKIWYLLVFTAFGAALTASFLFDKPIEPLTWLLLIGGVAAGSAAADTLTGYNDRDIDAIMDRTKNRPIPSGRISPKNALAFGLVLTAISLVCAWFINIWAFGLMAFGLFDNIIVYSKWLKRRSQSNIILGGFSGGAPALIGYVAVTTQNIEIGLVMAGLVFLWIPTHIWSLALHVKKDYTKAGVPMLPVVSSEKSSVRVIAGTTLMMVVFSILPFFFNQMFGIIYLATAAVFGAVMIALSVWLLVKPSEKASWTVFKFSSPYLTALFIAFMVDAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC61</accession>
    <name>K0IC61_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57130">
        <property type="protein sequence ID" value="AFU57130"/>
        <property type="gene ID" value="Ngar_c01810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01810"/>
    <dbReference type="HOGENOM" id="CLU_1438157_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-181-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="188" mass="20520" checksum="4EBFAF5602A6B52B" modified="2012-11-28" version="1">MAQFTCNVCGDGFDQKSRFERHMATSHPERAPSAADVEKALSGIQYPKTREELVRYASQQVSDKDLMDIINSLPSRVYRDSAEVAIALGEVKQRQGVRSAEEVAKTEAPSTKGGRAAATSSVSAATIAKVLSGTDFPKNKGELRDYAQKHMTEVEVADPQAIMGILDKLPDREYQDMADVEKSVGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICD3</accession>
    <name>K0ICD3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative quinoprotein glucose dehydrogenase-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02620"/>
    <dbReference type="EnsemblBacteria" id="AFU57210">
        <property type="protein sequence ID" value="AFU57210"/>
        <property type="gene ID" value="Ngar_c02620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.257"/>
    <dbReference type="HOGENOM" id="CLU_1850701_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-262-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15449" checksum="98FD75CCCBE8ADA2" modified="2012-11-28" version="1">MNESEFNATDFVPPIRTFYTVDNDYNFSEPAGCGYVCWPTVAPSSLRLYTSDVIPDWNGTFLMPTLKGGRIFHLALDECGAELASDPVELFRSENRYRDLAFSPDSKSIYVIILTRLGQCRLLGTAAVRSLTSRTQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICD7</accession>
    <name>K0ICD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methionine-R-sulfoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57215">
        <property type="protein sequence ID" value="AFU57215"/>
        <property type="gene ID" value="Ngar_c02670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02670"/>
    <dbReference type="HOGENOM" id="CLU_3194625_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-267-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="45" mass="5146" checksum="1F9F5BFEB30A6E6B" modified="2012-11-28" version="1">MLEQGHRPPFSGEYNNCKDKGIYKCVYCGISLFSSDEVRLGYRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICE4</accession>
    <name>K0ICE4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphosugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21150"/>
    <dbReference type="EnsemblBacteria" id="AFU59046">
        <property type="protein sequence ID" value="AFU59046"/>
        <property type="gene ID" value="Ngar_c21150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21150"/>
    <dbReference type="HOGENOM" id="CLU_077866_0_0_2"/>
    <dbReference type="OMA" id="FRCVDPY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2113-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="305" mass="33294" checksum="CA3CECFCD3AFA641" modified="2012-11-28" version="1">MNAIEAMQEEIGCQVEGLSRQELLPRRDENCLFVGSGDSYVAGLVAQHVSGGRAICCYPTDLIQNPLSVASGRSVYIVSISGSTKANILAAKVAKRRGVCTTAITARLASPLARACDRTIELKYKSTGVTTSGTISFTSSMLTCISLVTKVTLPDLTKIYRHAEKQAGQIAGEIGTKKSNYFILGNGVLHPIAIYGALKFNEVFGAKAMPYQAEEFCHSPLFSAKNGDQMIVMGSDGKRLSDRLMQEGFSSVHVDFKGTGIELLLQSTFFMQLLVLRLAQRRRMTSCYFLNNKRLLRTSSDFIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICJ0</accession>
    <name>K0ICJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57310">
        <property type="protein sequence ID" value="AFU57310"/>
        <property type="gene ID" value="Ngar_c03620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03620"/>
    <dbReference type="HOGENOM" id="CLU_2930304_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-362-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6224" checksum="62DF5F6746194D83" modified="2012-11-28" version="1">MNNNLVVGLAIGLLAAAVLIMLHHWNKHGYIIDKNDVNSHEFFAGLASALGAGLLIGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID32</accession>
    <name>K0ID32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59291">
        <property type="protein sequence ID" value="AFU59291"/>
        <property type="gene ID" value="Ngar_c23660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23660"/>
    <dbReference type="HOGENOM" id="CLU_3194629_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2364-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="45" mass="4637" checksum="BE51D3A456E7E3D5" modified="2012-11-28" version="1">MPLNNKATAASVITTGAANIGNTIVAIARAITSTPIPAWAARWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID63</accession>
    <name>K0ID63_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24010"/>
    <dbReference type="EnsemblBacteria" id="AFU59326">
        <property type="protein sequence ID" value="AFU59326"/>
        <property type="gene ID" value="Ngar_c24010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24010"/>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OMA" id="PMNGWDE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2399-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="23415" checksum="3BD8E1BEB1EBE678" modified="2012-11-28" version="1">MVYWMYPSDIFSRMYAGEQSTNLYPKKEEAPSEIDDALQTNLFNVMLNRRSQRKFEDRQVEDWKLEMIFAAADTAPTAGGFQGFEIYHVKNPDVKAKLVQAANNQPYVDAPVLLVFCMDPSRVKMNFPPHIIKKFSVQDATLAAAYAQLAAHALGLSSVWIGMIDEQKVMQALGTDLVPSCMLCIGYPQKMLHAKPKRNLSELIHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID79</accession>
    <name>K0ID79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59346">
        <property type="protein sequence ID" value="AFU59346"/>
        <property type="gene ID" value="Ngar_c24220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24220"/>
    <dbReference type="HOGENOM" id="CLU_1227689_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2420-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="22784" checksum="3D18813C39870DF1" modified="2012-11-28" version="1">MKNDEVVIRVHDSAGNIKSEQKAHNIITSAGAIYFCVQMNRCESHITGETPNVVSVANPTWWVQFISGTPNSNEPTAADCTAPSGGGALSGVVSAGRCITSFGAPPAQYQAGGSIITVSATTGSGQLRGTGTFDTTNNFVQLTPATVCSIVNDGTAPSSGTCQFTDSTPVLTNMSGGTITINGLALASGDGSNTAAGPLIIAESAITAVTLNPNDTISVSWTIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDG2</accession>
    <name>K0IDG2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmA</name>
        <name evidence="7" type="ordered locus">Ngar_c25180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25180"/>
    <dbReference type="EnsemblBacteria" id="AFU59441">
        <property type="protein sequence ID" value="AFU59441"/>
        <property type="gene ID" value="Ngar_c25180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25180"/>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_2"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="6">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="241" mass="26906" checksum="A36C4CD918B6CE64" modified="2012-11-28" version="1">MPNITKTLGQHMLVDARVLGKIIDAARISKNETVLEAGTGRGILTAELCKVARHVVSYEVDRKLYQQAQERLQFQNLELANADLFKTTGLRFDVFVSNLPYSRSRDAFEWLAVQKFNRAIVMVQEEFADKLAARPGSKNYRAISALAAHCFAIERLFSVGRQSFQPQPKVESVVIRIVPTNTVTKETIKNLNLLFSKRNKKASTVAAKARVKVDFGSKRVDQLAPGDLIRVAESISNVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDX4</accession>
    <name>K0IDX4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57023">
        <property type="protein sequence ID" value="AFU57023"/>
        <property type="gene ID" value="Ngar_c00730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00730"/>
    <dbReference type="HOGENOM" id="CLU_2821035_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-73-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7938" checksum="07C6930913C2A96C" modified="2012-11-28" version="1">MLLRLDKAYQAFFKKLARYPNFKRKGKYNSFTYPQYNNGWKIRDNKLMLSCMGAIKIKCIGYLLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE30</accession>
    <name>K0IE30_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c26950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26950"/>
    <dbReference type="EnsemblBacteria" id="AFU59616">
        <property type="protein sequence ID" value="AFU59616"/>
        <property type="gene ID" value="Ngar_c26950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26950"/>
    <dbReference type="HOGENOM" id="CLU_028780_2_0_2"/>
    <dbReference type="OMA" id="DGGLYIK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2695-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="371" mass="41476" checksum="819AD3C25F1CA50A" modified="2012-11-28" version="1">MADAQAILLLLRQYKLCRRCFERNNAAGGGRSKPDRRQCYICRGLMDSIDSIVDKIIGAVRDYEFETFVIGATLPTQIYEREDAMRARLKIRGRESVKNQLTKELGMRLARLIRKKAEYMKPDLTVSLVIDKENNVDVAVKSRPLMLSGRYVKKSRGVPQKQDRCPDCEGRGCSSCNNTGGLSGNGSVEGVIAKGLVEMTGGQAPKFSWIGSEDQSSLVLGSGRPFYARIYNPKKRKLKRSRISGSGVVATLSVIEEEDEPDLQPRFKVKTRIHAKCEKELTKDDMKKLGSLAGAEVSYENRSKMATKKIYSAWARRINDNQFSLTMVADGGMMIKQFVGGEEYMKPNISEILGKKCECVGFDILDVSLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEK5</accession>
    <name>K0IEK5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58180">
        <property type="protein sequence ID" value="AFU58180"/>
        <property type="gene ID" value="Ngar_c12400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12400"/>
    <dbReference type="HOGENOM" id="CLU_199471_0_0_2"/>
    <dbReference type="OMA" id="GHREYSK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1238-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="7033" checksum="BEAB0DB6201C3244" modified="2012-11-28" version="1">MKLQRRFNRKVGHREYSKWIVNLPPQDVERVGWEEGTDLEVIVKDGKLILKPKSQEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEQ2</accession>
    <name>K0IEQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58235">
        <property type="protein sequence ID" value="AFU58235"/>
        <property type="gene ID" value="Ngar_c12970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12970"/>
    <dbReference type="HOGENOM" id="CLU_2379518_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1295-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10653" checksum="0767EDB4DDD9040B" modified="2012-11-28" version="1">MEKCPVHTEFFDDSCEACKREYLEMKDAGEPVTSEKKYKEFTEERAKKLYEELMLQYLKSGATETDADRKAKAIIRKQCSIRGMPHWPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF38</accession>
    <name>K0IF38_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">argH</name>
        <name evidence="4" type="ordered locus">Ngar_c14590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14590"/>
    <dbReference type="EnsemblBacteria" id="AFU58395">
        <property type="protein sequence ID" value="AFU58395"/>
        <property type="gene ID" value="Ngar_c14590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1423"/>
    <dbReference type="HOGENOM" id="CLU_027272_3_4_2"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="3">
        <location>
            <begin position="376"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="512" mass="57077" checksum="DFB9A31EC18FAA5D" modified="2012-11-28" version="1">MLLYNLKIKRPRCTLLYMYRSRPKDKLDDHVLRFLSSMQHDQSILYYDILGSEAHSIMLHEMGHLTSGELKKILSALEDAKKNPDRIETEGYEDIHEALEAFVIKRAGMDAGGKMHTARSRNDQVVLDIRMKIRDDINEICTALASLIEGLVEKAKETKQAAMPMYTHLQQAQIGTFSHFLLSYAYALMRDMERLYLVYQRVNQSPLGACAIGGSSISIDRKRTAVLLGFDSIVRNSIDATSSRDAFLEYAATLAILTSTLGRIAEDFIIWSTSEFGYIELADRYSSTSSAMPQKKNPDPLELTRAKAAIVASNLVSMLGIVKALPSGYSRDLQDVKPPLLGASAITLDTIRVIDGAARSLKVNKEKMCRAASTSYAIALDIAEQLVMKNKMPFRAAHKIVGALVNRAASMDNLPLAKLQLSDVTSVLKTQKAGVSIKPDEMMKIIKEMTPEKSLQVRKSTGSPNLQEQQEMIESLSQGVSNYKVGIQKRTKMVQGSFDNLNRIVRKYLQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF66</accession>
    <name>K0IF66_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57458">
        <property type="protein sequence ID" value="AFU57458"/>
        <property type="gene ID" value="Ngar_c05150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05150"/>
    <dbReference type="HOGENOM" id="CLU_887446_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-513-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="313" mass="36092" checksum="B53DC85A60B8F136" modified="2012-11-28" version="1">MIRSTGIEEREGNKIFDLVIYNRESKRAIMIECKSSIGDARKSVLTPLADQIKNVQDYKKELEDEIGGEIADIEYVICGLSQDIEEVGKALQDNNEPVCLWTVDLFRFTLKLFNLTGSADGEQTGKLIRKGQLHRDEKLRKSLFEKTESRGQIEGFKIAPTSHICRMLSRVFERIIQEVILTNTRQEKRFWLHELVQMTQKELPKLQAEDVQRITKELYELALQLKIIEVEKSLDKENDMAFILKIGARSARTLEKEINERYAEEKCRDRSPALALKEFEEFLKSNIGSLDYHLSRAAAEQEPSKAPDDNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFL0</accession>
    <name>K0IFL0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c06750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57618">
        <property type="protein sequence ID" value="AFU57618"/>
        <property type="gene ID" value="Ngar_c06750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06750"/>
    <dbReference type="HOGENOM" id="CLU_113319_1_2_2"/>
    <dbReference type="OMA" id="AHNCLET"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-673-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NikR_C" evidence="2">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14522" checksum="0464AD90B451ECE3" modified="2012-11-28" version="1">MSLPPGLLSEFDKSMKKAGFSDRSKAIQTALHSFIDQNDWDKGEDSRNGAGAIMMLYDNHAYSHDDAGTHIQHRYSDIISATTHMHLDHDNCLETIMVRGEIRKIKELAKSLSENRGIKSLKVHFVAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFU9</accession>
    <name>K0IFU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07400"/>
    <dbReference type="EnsemblBacteria" id="AFU57683">
        <property type="protein sequence ID" value="AFU57683"/>
        <property type="gene ID" value="Ngar_c07400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07400"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.715"/>
    <dbReference type="HOGENOM" id="CLU_825391_0_0_2"/>
    <dbReference type="OMA" id="ILSICAR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-738-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="81"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="342" mass="37181" checksum="A4A887528DC57C24" modified="2012-11-28" version="1">MTNMATQLNPLFHASLSLGDLGIVESVSNCLAPKLDELKGKKIVFSCDDKKMIPVDGWGLRSNSYSAATTVTTIRPIKENALVAAIDSSSVKLAETEEGSLYAIKCGIATAYAGRALMHFKIGPVLFYLSESTIRDSDLEDRLAKLVLLDDDFAKRLIRVRAERAVQKELASHFTNSIILVDGSLKASVFEDRERSLGKIAESCVLRKNMMIGISKGTRLKVLERAAAPLTKVPGPAYIEVDMIIKGLIRNTVGSNSMVKLEKNSPILRADIVGNRTEALGMLLGNDPVAGGYPETLRLAHYISTFTSTDMTCLRSHVLNSYDVTELAADDIRSMLLGSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG42</accession>
    <name>K0IG42_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18220"/>
    <dbReference type="EnsemblBacteria" id="AFU58755">
        <property type="protein sequence ID" value="AFU58755"/>
        <property type="gene ID" value="Ngar_c18220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18220"/>
    <dbReference type="HOGENOM" id="CLU_037990_2_3_2"/>
    <dbReference type="OMA" id="WATTIMG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1820-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="283" mass="30986" checksum="F6AC34FBFE22575B" modified="2012-11-28" version="1">MMAAGYDPVKYKISSIQNWNTVAPGYHSDWASKERGPFRSTAELIKAADIRSDDYVLDVACGTGAVSMHAARLLGPSGTLVGIDFSRGALGIAKSSVPTGHFAEMDAENIGFDVKFDRIVCQYALMFFPDPVRVLSQLWALLKKDDGKLAVAVHGMPEGVPYFSTVMEPVLRHIPDIRPEGAPTVHRFGNKADLQKVIASAGFSKISIEEFVFECEAGTFEEYWSDYMSTTANSIRATIEGRGLGVVSAIKAEAEEKARKFMKGGRIRFPWQVLIATAIRAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG61</accession>
    <name>K0IG61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57803">
        <property type="protein sequence ID" value="AFU57803"/>
        <property type="gene ID" value="Ngar_c08610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08610"/>
    <dbReference type="HOGENOM" id="CLU_798335_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-859-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="344" mass="37212" checksum="B550FE2D9BB62AA2" modified="2012-11-28" version="1">MIPTKIRGEDGRIRGNAIIGMVVAAMIVAMVPAIVAINNNGNADMIAEAANHKNRPYFKVIANNALYEPNAGKTNVFGPGGIFPFFNDTFSCGDAITCGVQVEGDRFRGVFKEGGGEENKFIAEYVSPITYGDHQVAGHKYRIELIDTLWNSSEVAMPTRQAQFLAEKGNVAFNQIQHGHSNIDRADVPMFFNDVALYGHVNVYDVTDGNKLVAENLFTHLMVGKVVDEEKAFENLQFTPATQTVVALFVVNIPSGVELPGGIGPLTPEQAISFTPLGDDTSLGSTPPVDYGQLEDEGLSTQEPMSQSTPWPVDNPEQPVFFTFLLFTDVKAGFSSNGQMAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG73</accession>
    <name>K0IG73_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57818">
        <property type="protein sequence ID" value="AFU57818"/>
        <property type="gene ID" value="Ngar_c08760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08760"/>
    <dbReference type="HOGENOM" id="CLU_2646042_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-874-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8748" checksum="D149D784B8A36BA7" modified="2012-11-28" version="1">MRHKWHVRRGYLKKIHMAVDIRKKKVVSLVVTSEDVHDSSRVLKKLVDHASENNDNVSCALADGVRTRQQGEFQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGA6</accession>
    <name>K0IGA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57858">
        <property type="protein sequence ID" value="AFU57858"/>
        <property type="gene ID" value="Ngar_c09160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09160"/>
    <dbReference type="HOGENOM" id="CLU_1792190_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-914-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16039" checksum="0B2CD08CCBDE4231" modified="2012-11-28" version="1">MGNAEPRGAIYEKVKEGYDSGLFEVGIHGYSGGTTYDTLDYETQLQRFKFANGKLTRLLGSPSQLFVPPLGKLNADTIRAMADSNPPIKASFQPETKARTRHRTRVQAELMYDTGRGIVEISDVNGIRIYTIFATTFLTRGSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGD5</accession>
    <name>K0IGD5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative magnesium transporter-C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c35480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60461">
        <property type="protein sequence ID" value="AFU60461"/>
        <property type="gene ID" value="Ngar_c35480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3552"/>
    <dbReference type="HOGENOM" id="CLU_079292_1_5_2"/>
    <dbReference type="OMA" id="AANLWLT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3549-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="147" mass="15421" checksum="6C292FAF5E980AF8" modified="2012-11-28" version="1">MVFEGIPTGYELRFLVDIGIALASGFAIGAERESRGKPAGISTHCLVIGGAAIFTFLSSLIDPNSTSRIAAQIVSGIGFLGAGIILKSESEKRITNLTTAAAIWYAAAIGMAIGYEFYFLVAVATAFAVGVPRIPHISKLIKKGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGK2</accession>
    <name>K0IGK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58935">
        <property type="protein sequence ID" value="AFU58935"/>
        <property type="gene ID" value="Ngar_c20030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20030"/>
    <dbReference type="HOGENOM" id="CLU_2505064_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2001-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9122" checksum="1B0BD7AA57418685" modified="2012-11-28" version="1">MLVSGVSLFLLVAFVGMAYPAVTQCVDYAYGYGQSQCREFGTRPSYLDPLMNETFAIGMLVLAASGGAVIGINQFKRSRGQELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN1</accession>
    <name>K0IGN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56967">
        <property type="protein sequence ID" value="AFU56967"/>
        <property type="gene ID" value="Ngar_c00170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00170"/>
    <dbReference type="HOGENOM" id="CLU_2340264_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-17-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11231" checksum="F041201FB8F916B2" modified="2012-11-28" version="1">MASVGIRYNFALLERSGISRKQYYKGLRALKNVDLVRKFGNKYLQTTLGKLVYHEILKIEKYAYHLNEMKMIDILKDSGQFSQHEVSALIKKMSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS0</accession>
    <name>K0IGS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21040"/>
    <dbReference type="EnsemblBacteria" id="AFU59035">
        <property type="protein sequence ID" value="AFU59035"/>
        <property type="gene ID" value="Ngar_c21040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2085"/>
    <dbReference type="HOGENOM" id="CLU_051638_9_0_2"/>
    <dbReference type="OMA" id="MFANDMF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2102-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="18463" checksum="B4DDED1B71A4255C" modified="2012-11-28" version="1">MSNNNNYTAPPGVTNYVAKNAKIGKNVKIWHFAYVGSEAEIGDNVMIGSLTHVDYKVKIGDNTRIEGSVYIPPLTVIGKNVFIGPAAAFTNDPYPMSPKMVGVVVEDGAIIGGRSVFKPGVRVGKNSVVAMAAVVTRDVPPDTVVMGHPARRVYSRAEYNRKKKEWESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH10</accession>
    <name>K0IH10_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58123">
        <property type="protein sequence ID" value="AFU58123"/>
        <property type="gene ID" value="Ngar_c11830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1125"/>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1181-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="229"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="419" mass="47356" checksum="B9CC1125705883E4" modified="2012-11-28" version="1">MRVKVVHDDINAGGGSERLAIITIGLLAEMGFKVDLASFKKPDIKQLKRDFGDIVDSVDINPVHLDLFSMIGLTNAIDNPSRVSTESKKGSQDTYGNDSDYNLIINTHGDLLPYYNRSKASDGDKKRIITYCHFPIVPQLIQENHDKSYMRFIRKWVGTEGLEEEDLQQRMLENILKTYDSMMRNTTVITNSNFSKKAIEERYGSAVKPIVVYPPVDVEKFRNIALHSSKRENMILVISRFSPDKQLENVIEVCKILIKDLKVNARIVLVGNIGAGDEKYLEKLKQSIRDYDLESKIRVEVDASFDRLLELMQKSKVYLHPLAGEPFGISIVEAMSAGLIPVVPNEGGYTEFVPEYYQFRTHRQAADIIGKILIASDNDMQAERSQLSESVLKFSNESYKAGLRKVIESLLPSRASLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH87</accession>
    <name>K0IH87_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58223">
        <property type="protein sequence ID" value="AFU58223"/>
        <property type="gene ID" value="Ngar_c12830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12830"/>
    <dbReference type="HOGENOM" id="CLU_2115560_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1281-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12962" checksum="483686B77965C745" modified="2012-11-28" version="1">MTNQPNISIEGLKEKYRINEPIAFSITIRGVLKSGGLPHIEITKENSSKKKIYSIAFMSPVPPAASPEYVEQKLIFPIENDPQAPIHAGEAGTYVMTVSVYADVGKSYEVNRRILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA5</accession>
    <name>K0IHA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59295">
        <property type="protein sequence ID" value="AFU59295"/>
        <property type="gene ID" value="Ngar_c23700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23700"/>
    <dbReference type="HOGENOM" id="CLU_2802399_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2368-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7467" checksum="269FAC4878AAF921" modified="2012-11-28" version="1">MAIIKEFRKKKFKNIVIISGGITAFSDRDTQNNLVAYEQAILETVKKNRVGSGNLLLFAGIVRQDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB1</accession>
    <name>K0IHB1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c13350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13350"/>
    <dbReference type="EnsemblBacteria" id="AFU58273">
        <property type="protein sequence ID" value="AFU58273"/>
        <property type="gene ID" value="Ngar_c13350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13350"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OMA" id="FQGLRFM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1333-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="416" mass="46026" checksum="88DD409EC83685C1" modified="2012-11-28" version="1">MSYSNLSQMNFELSPDQNRFLQKVDSACRSIRPHEEKCYLEERLNDQVVPTFGRIGMLGCPVSRKYGGLGYDMLTYALAIERIGQEGASLRTFFSAHTSIGQLVIQGWGSEEQKKEYLPDTASGKSIMAFALTEPAAGSDPSSMTTKFESKGDHYVLKGKKHWIGNGTFAKVMTTYAKDPDSGKISAFIVERDSLGLRTEEMKNKMGLLTVKNAEIHFDNCIVPKKNLLGKKGQGLNIAYSALIDGRLSVAAGAVGVMEDCLQECVAHSKAREQHGLPLAKKQLIQDHIAMIATSIASSRWLVYRAAIARQKLHDYVEGIKSDDRSSKLGRGNKEYSQLRREADALAAIAKLHASNSAFETANRSVQVFGSFGYRKTARVARHFLDSRATLIYEGANEVLKLKIASQMLGDEYRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN4</accession>
    <name>K0IHN4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_OrfB_IS605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59455">
        <property type="protein sequence ID" value="AFU59455"/>
        <property type="gene ID" value="Ngar_c25320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25320"/>
    <dbReference type="HOGENOM" id="CLU_032903_4_6_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2531-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="9212" checksum="2E0EA4CBAC6A4937" modified="2012-11-28" version="1">MMRCHKFRLYPKEHQFKILNDTIETCRHLYNNSLGERSAGWGIGYWEQQNLLQESEITNITNRYTAKYCRMFYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP3</accession>
    <name>K0IHP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c15240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15240"/>
    <dbReference type="EnsemblBacteria" id="AFU58458">
        <property type="protein sequence ID" value="AFU58458"/>
        <property type="gene ID" value="Ngar_c15240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15240"/>
    <dbReference type="HOGENOM" id="CLU_045647_5_4_2"/>
    <dbReference type="OMA" id="YGFPEND"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1522-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="193" mass="21652" checksum="9D083C65EE98983C" modified="2012-11-28" version="1">MRDSLPENEIAARIEAALYSAGRPLSVDELIKASGTNSKEKTLRVVNELVKKTKTTFKAIEIAQLEDGAYVFQLRPEYTPLVRRFAQHPLIPSAALKTLSYIAYEQPVTSKRLVQIRGSQVYSHIRILEQLQFVEHENLGRLKVYRTTPKFQNYFGITDLNAMKSKLVATTNKQSPPSPRAAAAGPPRSPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS8</accession>
    <name>K0IHS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57407">
        <property type="protein sequence ID" value="AFU57407"/>
        <property type="gene ID" value="Ngar_c04610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04610"/>
    <dbReference type="HOGENOM" id="CLU_2340266_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-460-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11612" checksum="179C1852D318C60B" modified="2012-11-28" version="1">MYQKAGLLRKPHDKVLQIQANPTEHQVKILNDTIETCRHLYNNSLGERSAGWGIGYWEQTYILPLRKHDNKYYKCTVKSYRMYCRGLIRRILHFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0II12</accession>
    <name>K0II12_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58573">
        <property type="protein sequence ID" value="AFU58573"/>
        <property type="gene ID" value="Ngar_c16400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16400"/>
    <dbReference type="HOGENOM" id="CLU_3227953_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1638-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="43" mass="4567" checksum="6877A1A6A5DD6921" modified="2012-11-28" version="1">MTPEQQIFSKEKQTSLLAKGFRDGYVAFGLGVAGMDTLSGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0II34</accession>
    <name>K0II34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57637">
        <property type="protein sequence ID" value="AFU57637"/>
        <property type="gene ID" value="Ngar_c06940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06940"/>
    <dbReference type="HOGENOM" id="CLU_3075469_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-692-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5915" checksum="BF974004DAB8B2DD" modified="2012-11-28" version="1">MIGKDGISTKVVFTMLSWQESRAYGKRVLKKKRIVVAEILSSILLFGLVFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0II55</accession>
    <name>K0II55_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hom</name>
        <name evidence="11" type="ordered locus">Ngar_c16950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16950"/>
    <dbReference type="EnsemblBacteria" id="AFU58628">
        <property type="protein sequence ID" value="AFU58628"/>
        <property type="gene ID" value="Ngar_c16950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1672"/>
    <dbReference type="HOGENOM" id="CLU_009116_1_2_2"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="10">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="9">
        <location>
            <begin position="155"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="335" mass="35537" checksum="412FDED3936C4393" modified="2012-11-28" version="1">MRVIVVGFGVVGQSFAKLLLSRSADLYSKYGIKPRIVACVDNDGSAVAPAGLDLQRLLDAKKTKGTVGAYERGGKFSPLQVIESVEAEVVLECTPTNLNDGEPGTSHIITAMRTGKHVISVNKGPLALAFPSLIELANYNGVMLRFSGTVGGGTPILEFAKRCLKGDRITSFKGILNGTTNYILSKMEEGLTYESALQDASKKGYAEANPSLDVDGFDAAAKLVIMANWVMGMKVTMKDVKRTGITKVTVTDVKKAAQRGNAIKLIAACDSRQLDVTPSEVAKTDPICVNGTLNAVTFSSEHSGQQTIIGRGAGGMETASAVLRDLIEIRDTTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA4</accession>
    <name>K0IIA4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl24p</name>
        <name evidence="2" type="synonym">rpl24</name>
        <name evidence="5" type="ordered locus">Ngar_c17400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17400"/>
    <dbReference type="EnsemblBacteria" id="AFU58673">
        <property type="protein sequence ID" value="AFU58673"/>
        <property type="gene ID" value="Ngar_c17400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17400"/>
    <dbReference type="HOGENOM" id="CLU_093240_2_0_2"/>
    <dbReference type="OMA" id="KICVEGI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="17469" checksum="10071FD9034B2F99" modified="2012-11-28" version="1">MAIVIMADINPKLIHVSKHRRDKMLGASLADELREQYKKRTLRVVKGDSVMVVRGEYKGRGGKVEDVDTEHGTLHIEGMQREKIRGGQVKVPIHASNVKITALNLEDKYRSNKLQGGGKPQAAEKKEEKAEKNEITAAAAKKTTKKEERKKEEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC4</accession>
    <name>K0IIC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K+ transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c27540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59675">
        <property type="protein sequence ID" value="AFU59675"/>
        <property type="gene ID" value="Ngar_c27540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27540"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2731"/>
    <dbReference type="HOGENOM" id="CLU_451740_0_0_2"/>
    <dbReference type="OMA" id="QATQFFI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2754-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="617" mass="67343" checksum="11D63A068B884400" modified="2012-11-28" version="1">MASYATNRFLLIDGRTNVAVAVRQMQVNKMEAIVVTHGGSPVGIVTDSDILEKVVIKGEDSDEVLLKDVMTSPIITLPKGSTGKEALESMKSNKIKRILITDRENGGNDRIIGMVTQKTLANAVRTSVIERTFRKYRASIRERYKPVLGNLGFVMQFAGILMVVPAFLGTAHEEFAPTTGMYLAVVGMFSTGFVLNAYGERGPLSLKEASILVISSFILLSFFGSFPYMYLNPFWPEIDGLSLFVNSFFESISGFTTTGMTMITQPENLPQSFVFFRSYTQWIGGLSFIYLIMAIFYPEKKLKAIRGVLGGDALEYRQLIVTIVLIFSAYTAVLFLILLFLNVSNPVYDISLVFSAIVGGGFTPDSTIVSVGNIVHLLVASVAMIISALPFAFHYSIFYKSMRIRKIGIEVLAYIVLLVTSAAILAAIAGIEWLPAAFHSVSASTNTGFQFVDIQVLPTEAKIVMIVLMLIGGTAFSTAGGIKIGRFLLLFQKLVKRTDMIETPSSISRLAVVPDQAIDFKAKKESDKLLRETLLVIALFPAVAVLSGLALGYLNNANTLDAVFSSTSSLTNTGLQVGLVSMDSDLITKSILAANMIAGRFEIIAILYIFFASLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0III2</accession>
    <name>K0III2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase IS116/IS110/IS902 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57877">
        <property type="protein sequence ID" value="AFU57877"/>
        <property type="gene ID" value="Ngar_c09350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09350"/>
    <dbReference type="HOGENOM" id="CLU_2079492_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-933-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="16485" checksum="304635C2F788DD1D" modified="2012-11-28" version="1">MTIISDLFTEKGKEYLRSLKISAVDDCLDDTIEFLDRKILQLDREIKKMATTDDRYARHLMMTIPGISYYAALLISAEIADINRFSDYEHLCSYAKLIPGTYQSGDKQYQRPDMKGNDMLNWIMIQCTHVHVQYCHSIRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ2</accession>
    <name>K0IIQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphosulfolactate synthase</fullName>
            <ecNumber evidence="2">4.4.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">comA</name>
        <name evidence="2" type="ordered locus">Ngar_c10400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10400"/>
    <dbReference type="EnsemblBacteria" id="AFU57982">
        <property type="protein sequence ID" value="AFU57982"/>
        <property type="gene ID" value="Ngar_c10400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10400"/>
    <dbReference type="HOGENOM" id="CLU_062679_2_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043817">
        <property type="term" value="F:phosphosulfolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="SSF102110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="328" mass="36803" checksum="187FFBEF2E2A2E7A" modified="2012-11-28" version="1">MLEDYAKNRVDGKKPRKEGRTYVIDKLQGLDKENFEALAPFVDAVKIYGVLPLILPEPVLQRKIKFYQDLGVKVSTGSTISEYMVAENAFDKFVAAAATIGFDIIEIGENSLDLTFEQKKKITDAILAKNLEFQWKVGKKDPRHQLSIDTVTAKVEEAVKLGSDKVVLEANEGVNVGIYDEKGAIKWNFVGALTAKFPPNTFIFEAPLEHQQSALIAEFGQRVNLAEIHVDAVSSIESQRRGFPTKASFSVSYLRKEPEGGPGAKFVYFIIKTRHPIDQVQIMEMSRLPRRTVQSAIDELKNQGLIIERSSLDDARKKVYSPVQSIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ4</accession>
    <name>K0IIQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59815">
        <property type="protein sequence ID" value="AFU59815"/>
        <property type="gene ID" value="Ngar_c28960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2873"/>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_2"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2896-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="14136" checksum="3CE76D0570A34952" modified="2012-11-28" version="1">MTILTKRVYDLPSKDDGYRILVDRLWPRGISKSDAEVDMWLKDVAPSDSLRRWFNHRPERWGEFKSRYFQEFAKHDKKDLLQQIRTKEAEVGVVTLLYGAKDQLYNNAVALKEYLERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT0</accession>
    <name>K0IIT0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58983">
        <property type="protein sequence ID" value="AFU58983"/>
        <property type="gene ID" value="Ngar_c20510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20510"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="OMA" id="QWCVEDD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2049-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="147" mass="16196" checksum="4AA3482F3D44694A" modified="2012-11-28" version="1">MSAVSEIVSPRKIVALRVDRTPSALDAAKLMVKNKVGSVVVVDFEEKPVGIVTERDILKKVTALNKSPREIAVQDIMSFPVITIKTYDSIETAAAVMAKNKIKRLVVLEQDGSLVGVLSITDITRKLAKILANDYKRYGHFKAILDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT6</accession>
    <name>K0IIT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FeS cluster assembly protein sufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sufD</name>
        <name evidence="2" type="ordered locus">Ngar_c10850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10850"/>
    <dbReference type="EnsemblBacteria" id="AFU58027">
        <property type="protein sequence ID" value="AFU58027"/>
        <property type="gene ID" value="Ngar_c10850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10850"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1028"/>
    <dbReference type="HOGENOM" id="CLU_026231_3_1_2"/>
    <dbReference type="OMA" id="PGRDWTN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="474" mass="52783" checksum="311EEB22477C0015" modified="2012-11-28" version="1">MMTTTALSSISNGYIDSLADKDPGWLAAMRRQAFSQYESLPAEVSPLYSKYSDVNKIKPASVHFAAQTRQQSALGKDLTDRLKELEQETGVLQVGQKIHRVFVRDSVAKQDVIVSGIKEALSKHGDLIKSRMEANPLNYLEDKFLALEASAFQSGIFIYIPRNVVLEDPIRVITSLADDGTSLVSRNIVVADTGSKATVVQELYAPGSSGRQDVQQGYFELVETHVSPNAHLEMVTLQAMGADTVNVSNRKAFVERDGKMSWYIGMFGSLLSRYKTDSVMKGPGASAEDVEIIFGVGNQSFDVMSNLIHHGQHSRGRVLVKSVLKDTSKSLFKGMIKIGKEGKGTESYLAGHAILLDRGAKSDSIPGLEIETNEVKATHSASVAQIDENQIYYLMTRGLSREGAKREIVSGFLEPLSRKMGPTIRAWVNYLIENKWQGRQLMLRTDEAMEQILEVEKSRYRETQDIFEKHYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV6</accession>
    <name>K0IIV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c29870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59905">
        <property type="protein sequence ID" value="AFU59905"/>
        <property type="gene ID" value="Ngar_c29870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29870"/>
    <dbReference type="HOGENOM" id="CLU_1136084_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2987-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="26155" checksum="C5CF7919C485B9F2" modified="2012-11-28" version="1">MVYVIIVRHLALAAPLALIIVLSVVQPAFAQEDDDNNLTEPRGALKSNATEGSLLNATRSDEPVLEQTSEKGIYLVEIRWPQDPVSVFQRILQIEIAFLNASSPRPTAENFPQTETNTTGQSTPGASGFTDPRMIETTLPVESYDIAIYAADDGRELWKKMDQPGLGGRGTQRIDLEGNYTGPVTINITDIRPGWSAGGTTTAEELTDSVSFTATIVPEFSVAASLILAGSVAAGIAAARLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ05</accession>
    <name>K0IJ05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11820"/>
    <dbReference type="EnsemblBacteria" id="AFU58122">
        <property type="protein sequence ID" value="AFU58122"/>
        <property type="gene ID" value="Ngar_c11820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11820"/>
    <dbReference type="HOGENOM" id="CLU_1014170_0_0_2"/>
    <dbReference type="OMA" id="HLVKSFY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1180-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="274" mass="30865" checksum="DBA831F631104E6B" modified="2012-11-28" version="1">MPHTNNSDFKMRTTEYSIDARTERTVGDKVAVIFCTKNSAATIQNAIKAIKNSNYDLDSIIVVDGFSNDKTVEKAKQGGATNVITQPEKKFPGKGIAMKAGIEESRKAGADVALFLDSDIKNLSGQWVDALVDPILEEGYDMTRGFYERAPRDAAVTKLVARPMLSVFFPELSHFEQPLSGEVCARMQVWEDLLNRDAKPPDGWGIDVWFFVEAAMSGHKLREVYLGRKEHTSFDGYKEDIGKLHKMSEQVLFTILNEAVKYDRFEQHYNRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC6</accession>
    <name>K0IJC6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59218">
        <property type="protein sequence ID" value="AFU59218"/>
        <property type="gene ID" value="Ngar_c22910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22910"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2289-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9857" checksum="B62ABFE1D82431C1" modified="2012-11-28" version="1">MKYRSRTEIVAMILEAANGGATKTKIMYKAFLSYAQLREYLSVLIENGLLEYMEGTQTYKTTAKGLNFLKMHSEIGELLQTTVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC8</accession>
    <name>K0IJC8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60125">
        <property type="protein sequence ID" value="AFU60125"/>
        <property type="gene ID" value="Ngar_c32090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32090"/>
    <dbReference type="HOGENOM" id="CLU_2044520_0_0_2"/>
    <dbReference type="OMA" id="PECGTTQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3209-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_2" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15185" checksum="BF86D67AAC3D4458" modified="2012-11-28" version="1">MAMAKAFNGRAATEEYMSTHSLTFSTPEMTLRKFALWLGEQVNLPGGERGPRLLLYVEEKGAKKESELAPDIDDSFRPSGAVTEMYGGIESAAPTEAMTPPQLTPLDRETLEPETKFCTSCGNKLKANAKFCTKCGSAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD5</accession>
    <name>K0IJD5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32190"/>
    <dbReference type="EnsemblBacteria" id="AFU60135">
        <property type="protein sequence ID" value="AFU60135"/>
        <property type="gene ID" value="Ngar_c32190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32190"/>
    <dbReference type="HOGENOM" id="CLU_1052177_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3219-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="264" mass="30204" checksum="2063F3FCF20BF55C" modified="2012-11-28" version="1">MQGAYKAYQQFLARRPPAHHARYIFPFFAGSYFAYRKVDVERVTAIAKSISPDPSYVDVGCGYGDFLEKVRTRLPNATGIEKEGGIFYAFQIPKPDYIQLVPVEGLSQPVDLAFVGWMEPGQDFRRPVARWAKCVVTTFDAGGQCGINGGCEYDEFGYKRIAWWRTPSWIDVNAELMNRYYTPSLDAAKKEQLAKLRTAHNFWYVYARPDVASRIRSGLKAQLNKEDAGDRYDFESVLDECGFHYKEELPALAGNRKLWEVIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE6</accession>
    <name>K0IJE6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58382">
        <property type="protein sequence ID" value="AFU58382"/>
        <property type="gene ID" value="Ngar_c14460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14460"/>
    <dbReference type="HOGENOM" id="CLU_2021578_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1444-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13580" checksum="E51CFC67FC7CBBD4" modified="2012-11-28" version="1">MSEISVQQFARSVLSGSSQKYELTGKKKVIYNLLVTSDYNGETIAEKTGTNTEYPYKVVNELKKKGWLPQDFALRDRRGKLDTNSYRTSGTGKSSGITANQSHPDSHNNDEGCRPADFRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI9</accession>
    <name>K0IJI9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="8" type="ordered locus">Ngar_c32650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32650"/>
    <dbReference type="EnsemblBacteria" id="AFU60180">
        <property type="protein sequence ID" value="AFU60180"/>
        <property type="gene ID" value="Ngar_c32650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3261"/>
    <dbReference type="HOGENOM" id="CLU_089358_3_1_2"/>
    <dbReference type="OMA" id="SGPGMTR"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16058" checksum="9BDFD294FD8D7840" modified="2012-11-28" version="1">MVSEFNSEITFKMLERARNHAGKIGAKVSYVLYVPGTFDMPLAVERLLKKKNIDAVVTLGAVIKGDTRHDDIVAENAARLIADLSLKHGKPVALGVTGPGMTIDQARERAELVPVRAVNAAVNMVARLRKLQKAVGEGTVVINDTADNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ7</accession>
    <name>K0IJJ7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c32800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32800"/>
    <dbReference type="EnsemblBacteria" id="AFU60195">
        <property type="protein sequence ID" value="AFU60195"/>
        <property type="gene ID" value="Ngar_c32800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32800"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3275"/>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_2"/>
    <dbReference type="OMA" id="THHPFMT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3280-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="501" mass="58371" checksum="1322CEA0AC2FBC59" modified="2012-11-28" version="1">MKSENPVINQVLDAYKPIWSINHATSLLGWDFETYMPKKGSEERGVAYSQLHLLHKGLLLSKNFVDLVESAKKQQEGLNDVEKGIIRILDRDITKQLKIPKELIEAESLERIRGNMVWRQAREKSDFKMYEPHLKKMIEIKKQIADKIGYEKHPYDVLLDQFEEELTVDDLDKVFGVLTPQIQKILKKLMDSGSPFCKESNLGKSRYDIQKVDELNRKILELLQYDMERFRIDVSTHPFTEAMGLNDVRITTRYEWTDFKRSISSTIHEAGHALYHLQCDQSLSVTPVEGGSSLGLHESQSRFWENIVGRSRPFIQLIAPLIRKQVNFANQATDEELYLYFNNVKPDYIRVDADEVTYNLHIAIRYEIEKKIFGDELDVSEIPQFWNDRMEQLLGVRPTEDSQGVLQDTHWSSGLFGYFPTYTLGNLVSAIIASKMRKDLKDYEENISKGDFKSIREWLRLKIHQHGSVYAPKVLLKNILNEEGYNPDYFVTYIETKYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM4</accession>
    <name>K0IJM4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60245">
        <property type="protein sequence ID" value="AFU60245"/>
        <property type="gene ID" value="Ngar_c33300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33300"/>
    <dbReference type="HOGENOM" id="CLU_158387_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3330-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14766" checksum="C37C065383BADF8A" modified="2012-11-28" version="1">MSEDKQQEQSRQNILTLLDGFIEQIQQIRRILLGMSLSAIILAPLAIALSVYLILHPSFFEILQIENEFGLILSILLGAVIIISAIWLLTGIKQYYSMNHWKNRYIEYQNEKEAIDKKIASQFGLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM8</accession>
    <name>K0IJM8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c24910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59413">
        <property type="protein sequence ID" value="AFU59413"/>
        <property type="gene ID" value="Ngar_c24910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2468"/>
    <dbReference type="HOGENOM" id="CLU_2165347_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2489-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="13112" checksum="71F8024B3E21B333" modified="2012-11-28" version="1">MSDQESNRIRRIVGWGIIGLIAVIGVSIALSLYFVPGRPGAFFPFPFGWLGGIFLIFIVFWVAKWFLWPWRGWYRYEYRTAESILKERYAKGEITREQFEQMMHDLERKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK43</accession>
    <name>K0IK43_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">crcB</name>
        <name evidence="7" type="ordered locus">Ngar_c35920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35920"/>
    <dbReference type="EnsemblBacteria" id="AFU60505">
        <property type="protein sequence ID" value="AFU60505"/>
        <property type="gene ID" value="Ngar_c35920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3600"/>
    <dbReference type="HOGENOM" id="CLU_114342_3_1_2"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="17247" checksum="914767749439CDE7" modified="2012-11-28" version="1">MTGYGISLGVSQNRPFSKGADNAYQQLKGWWAMGKMKGVEFAFLAVGAIAGAFVRYKLAESPLILGTLPVNILVINMIGSFILGVFSILSVLWNLDTRYSLLAAVGFCGSLTTMSSFALETSSLIDNRQFGNAAVNILANVSLSIGAVVGGRSIASVLLMKGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR2</accession>
    <name>K0IKR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30000"/>
    <dbReference type="EnsemblBacteria" id="AFU59918">
        <property type="protein sequence ID" value="AFU59918"/>
        <property type="gene ID" value="Ngar_c30000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30000"/>
    <dbReference type="HOGENOM" id="CLU_103221_0_0_2"/>
    <dbReference type="OMA" id="YYFIFQR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3000-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_7" evidence="1">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="230" mass="25445" checksum="AB5FCF2093A56ED0" modified="2012-11-28" version="1">MLVNNEKSITNAVKEVVNNDLSFQDSLQRDYCNISALARLIKPHVDQLLGGKNTSIESIVTALKRSRRDYDVPEKPIASILAGSTISVRTDVAKVSAEKSKKTIEKVAKAMTQNVGNFISVSESIMSITLVFDDALLDEVKAMFAHDDILEIEDDLAAIIVHSPEEIIKTPGCAIAFYNQLARRHINIEDTVSCYTDTIVLVKMEQVGKAFNALTDLISGSRKMPKKKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKY3</accession>
    <name>K0IKY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative orc1/cdc6 family replication initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31370"/>
    <dbReference type="EnsemblBacteria" id="AFU60053">
        <property type="protein sequence ID" value="AFU60053"/>
        <property type="gene ID" value="Ngar_c31370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31370"/>
    <dbReference type="HOGENOM" id="CLU_1340765_0_0_2"/>
    <dbReference type="OMA" id="WIGIAND"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3137-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="23868" checksum="66BB6EAB324ABF8D" modified="2012-11-28" version="1">MDEVDQIRQPQVLYTLARYGFGLLMISNHSFINWDLDGRIKSSLILNEVEFKPYSKEELYDIINQRVSFALRPRRIEPHLIRAVSVMAEGDARVGLLMLKASAKNAEARSADNITLDDVKTSLKGARRLRVSYLLKLNEHQRVLYDIMKKRIRITSADLYKEYRRSTPKPLVDRAYRRHMQRMIQLGLVKEEGSGRWKRYEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL16</accession>
    <name>K0IL16_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c31870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60103">
        <property type="protein sequence ID" value="AFU60103"/>
        <property type="gene ID" value="Ngar_c31870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31870"/>
    <dbReference type="HOGENOM" id="CLU_040681_7_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3187-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044065">
        <property type="entry name" value="ACP_MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51901">
        <property type="entry name" value="ACP_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="88"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ACP-type MB" evidence="3">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="21986" checksum="F4BDB5814A913EBE" modified="2012-11-28" version="1">MVKKPVREHADANMTTRVLVRDIMNSPVVSASPDDTIRDIAKKMKEEKIGSIVIIEKDKPVGIVTDWDIVSNGLVKDARPSQIKAKDVMQKIHTIESEESITEAARQLRKHNIKRLGVVYKNRLVGIISSSDVIAVTPDLVDVVSEKAAIIRGELGITRHAGNVSGYCDECGEWSDLLQYDEGTFICEVCRGESSGGAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL53</accession>
    <name>K0IL53_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59332">
        <property type="protein sequence ID" value="AFU59332"/>
        <property type="gene ID" value="Ngar_c24070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24070"/>
    <dbReference type="HOGENOM" id="CLU_3113194_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2405-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5823" checksum="588E0C121A53E3D2" modified="2012-11-28" version="1">MALLDDVEFRIKAETIYFCQQCKTKFLFVHDAASHAEMFGHKRMSELPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL93</accession>
    <name>K0IL93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60253">
        <property type="protein sequence ID" value="AFU60253"/>
        <property type="gene ID" value="Ngar_c33380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33380"/>
    <dbReference type="HOGENOM" id="CLU_2191108_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3338-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12198" checksum="C352CCA2FDC5B812" modified="2012-11-28" version="1">MTIIIMLLTARPPLPQTWKKFLHMQGRNRDIKSFSDKDIQSLQNGTGEAFGVMAKLAELNGYPGPQHVLDMASELQLTDSQRTEIEFIYQDMSAKAKSIGGCNYRHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD0</accession>
    <name>K0ILD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34130"/>
    <dbReference type="EnsemblBacteria" id="AFU60328">
        <property type="protein sequence ID" value="AFU60328"/>
        <property type="gene ID" value="Ngar_c34130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3408"/>
    <dbReference type="HOGENOM" id="CLU_024775_0_1_2"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3414-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="433" mass="47752" checksum="9D8F0D98D060792D" modified="2012-11-28" version="1">MDCKVAIIGGGVLGTSIAYFLSAHARDPGSVALIEQEKNIAQHTSSRNTGKVHAPFLYDPAKKKTFAKAAFLGYEMWQKYSDYKGLPFKRDGVLEVALDEKGIDRLQKYMEWGEANGLGKSELQLLDKNEAAKMEPNVRCASAIYCSKDASVNYGALALALMEDIQSFGCKLLLGHRAARISYNQGAYSITTNQGEQVRADYLVNAAGGNSMDIAHMMGVAQGYTDLHFRGEYWQAPSQYHDLTKLSIYSVPKHPEYSFLDPHWIVRADGRREVGPNAVPVFGPYAYTWRKNIADMLPKIIESSRTGARKIVFDRQFMSLASTELKSSLSKTAMINRVREFLPQLRPSAFTQRGTAGIRSSVIDKTGRFVPDTLVLERDSSLHVLNYNSPGATGALPMAADVASKVMEAGVLQTDSKPRSLWDATAIAEKMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF5</accession>
    <name>K0ILF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, RNase L inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c34680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34680"/>
    <dbReference type="EnsemblBacteria" id="AFU60383">
        <property type="protein sequence ID" value="AFU60383"/>
        <property type="gene ID" value="Ngar_c34680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3468"/>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_2"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3469-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="312"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="80"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="569" mass="62988" checksum="6D4D021B33487BE4" modified="2012-11-28" version="1">MNKTGGACIVQRPEDNKALISEDLCTGCGICIKKCPFDAIVIVNLAKELSTDKVHQYGINSFRFYRLPTPKKGAVVGLVGRNGIGKSTIVSVLSGTMKPNLGKYDQDVSWDEILKYYQGTEMKSHFEKIANGTMRASIKPQLVYLIPKAFKGTPKELLKKYDERKVTDKLVQQLGLQNILDRDVAQLSGGELQRLAVAVAAAKDAEYYFFDEPSSYNDVYQRLAVAKVMRELAEAGKSVMVVEHDMTLLDYLSDYVHIIYGEPGAYGIVSGMQSTKVGINNFLEGFLPAENVRFRDKAFKFDVSAINEDVILDIPAASYSDLAKSFPSFNLKVAAGKVRKGEIVGIVGANALGKTTFMRILAGVDKPDSGAIDVGAKISYKPQYLSQDYEGDVRSLMYTAYQSPIESSPVEEQIIVPMGVKKLYEKSVKNLSGGELQKVAVAASLLREADIYALDEPSAFLDAEDRIAIAKFLQRFVRARGKSAIIIDHDMQLIDLVADTLVIFEGKPGLEGFATAPMRKEEGMNRFLQVLSITYRRDETTGRPRVNKEGGRLDREQKQSGNYYYVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG9</accession>
    <name>K0ILG9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative CorA ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c25600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59482">
        <property type="protein sequence ID" value="AFU59482"/>
        <property type="gene ID" value="Ngar_c25600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25600"/>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_2"/>
    <dbReference type="OMA" id="MVEFKRA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2559-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="290" mass="33538" checksum="A36E05CF4B38D3E5" modified="2012-11-28" version="1">MDSKALEEYSNKSKKPQVRMLDTHVFTLMLDMKYSDAQTLVTEGIYIFLGRGWLVTIHPSAVDLTSIVKRILEEKNRPLLESSVDALYYSILSSIVDKYEQLLTAVELSVVDMEKRSVHKRPSKQMLEHLDDLSRQIIVLRRHFWHIRDVINFLIHVQEERPDIKYLKIVYDDINQLINLVESYQDTVNSTRELYIANISLLMNDTVKTLTVFSAVLLPLTFISSVFGMNGLDLNNIWRVPFGFVLVMAIMAASAAALFAFLKAKQWILVREDAKQANKRKKQGERSMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ3</accession>
    <name>K0ILQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-formaminoimidazole-4-carboxamide-1-(Beta)-D-ribofuranosyl 5'-monophosphate ligase</fullName>
            <ecNumber evidence="5">6.3.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purP1</name>
        <name evidence="5" type="ordered locus">Ngar_c02760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02760"/>
    <dbReference type="EnsemblBacteria" id="AFU57224">
        <property type="protein sequence ID" value="AFU57224"/>
        <property type="gene ID" value="Ngar_c02760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.270"/>
    <dbReference type="HOGENOM" id="CLU_065084_0_0_2"/>
    <dbReference type="OMA" id="CIHYFYS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="PTHR38147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004602">
        <property type="entry name" value="ATPgrasp_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="84"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="327" mass="37127" checksum="0FD8233E8662E822" modified="2012-11-28" version="1">MLKGAKDEGFHTLLICEKRRLGLYRRFGFIDEIIEVDSFREILEDKCRKRLRQANSVLIPHGTLISQMRSDEIEKIDTPIFGNKWILRWEADRELKEKLMNEAGLRTPRAVKSKDDLNGLCIVKLHGAAGGRGYYLAWNRESFEEGARRLIDQKAIRSENDLYIQEFIRGVPVYLQYFYSPVTGELELLGIDRRYESDIDGIGRIPAKQQLGAGVEPSYNVIGNIPLVLRESLLDEVYKMGESFVRAAERLVPPGMPGPFCLEGVYDSEGKFTTFEFSARIVAGTNLYLDGSPYSGLLYDDPMSMGRRIAREVKMASKKGKLGKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU4</accession>
    <name>K0ILU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57359">
        <property type="protein sequence ID" value="AFU57359"/>
        <property type="gene ID" value="Ngar_c04120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04120"/>
    <dbReference type="HOGENOM" id="CLU_2519869_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-411-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9326" checksum="A888B2E9BFB478CA" modified="2012-11-28" version="1">MATIRARLKQRWKMLAVVVGIWIVVMFPIPFLPLFGFPYDETSVHILLMISGIVSIPFTLLALFMNDGSNRNGTKEGTGASSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY8</accession>
    <name>K0ILY8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59807">
        <property type="protein sequence ID" value="AFU59807"/>
        <property type="gene ID" value="Ngar_c28880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28880"/>
    <dbReference type="HOGENOM" id="CLU_1500327_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2888-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20496" checksum="C05CA686E5EC7184" modified="2012-11-28" version="1">MSSADQILQQLDCAYGKHNVLIFGTLDILREFYSRFAKRALEDNDVVVLLSYYEPVKNVYAFLENAGIDVARYKKAHNLFVEDSVEQFFGTSSDFYKFLKILDEGAIHQGKKGVCVLASADAFHLHREVKDLREYENNLSLSKNLKNTSIICMYHAESFAALSKEDQDFVINKHDKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM17</accession>
    <name>K0IM17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29740"/>
    <dbReference type="EnsemblBacteria" id="AFU59892">
        <property type="protein sequence ID" value="AFU59892"/>
        <property type="gene ID" value="Ngar_c29740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29740"/>
    <dbReference type="HOGENOM" id="CLU_035527_4_3_2"/>
    <dbReference type="OMA" id="TYVPQCT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2974-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="1">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="14377" checksum="D863ED01126475EC" modified="2012-11-28" version="1">MNIYSESRPWGRFEKFHENKPCTVKLIYVNANSRLSLQYHNKRSEFWKVIKGTAMVELNDRNTVLKEGETISIPKQARHRVSALDSECVILEIAYGKFDENDIVRIEDDYNRAAMPAKTRVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM27</accession>
    <name>K0IM27_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59927">
        <property type="protein sequence ID" value="AFU59927"/>
        <property type="gene ID" value="Ngar_c30090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30090"/>
    <dbReference type="HOGENOM" id="CLU_152017_0_0_2"/>
    <dbReference type="OMA" id="VGHYDCA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3009-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14865" checksum="71553247ED6B4595" modified="2012-11-28" version="1">MSFKFGTAINCIDGRTQQRVIDYMVQNHDVDGVDMITFPGADGMFSSQERAVEVELARRAVSISVERHNSKVIAVVGHHDCAGNPVDKERHYMHIRRAVEKVQSWGLPTRIIGLYVNDEWQIEQVSQILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM86</accession>
    <name>K0IM86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07060"/>
    <dbReference type="EnsemblBacteria" id="AFU57649">
        <property type="protein sequence ID" value="AFU57649"/>
        <property type="gene ID" value="Ngar_c07060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07060"/>
    <dbReference type="HOGENOM" id="CLU_050006_9_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-704-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="16181" checksum="90827A76F308105B" modified="2012-11-28" version="1">MLRKLCKEARDSGISLVLEPLNRYSTPYCATASDALLLARHVDNLGILLDTFHMNIEEDSFEEAIFASRDFLVHTHFADNNRKMPGFAHINFKTIVTSLQKISYDGYVSFEPNIADRNYEYVTKKGLEFIREIEAFGRVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM88</accession>
    <name>K0IM88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alcohol dehydrogenase superfamily, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c07110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07110"/>
    <dbReference type="EnsemblBacteria" id="AFU57654">
        <property type="protein sequence ID" value="AFU57654"/>
        <property type="gene ID" value="Ngar_c07110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.685"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="ELITHEM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-709-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="188"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="365" mass="38871" checksum="C749457E62B883DB" modified="2012-11-28" version="1">MEGNCNNGTMMKDMQAAVFYGPNNISVQSAPFLQDRAALKVNACAVCGYDVRVFRKGHRKVSPPVILGHEVCGQITENVNMNSGTIQADTRVALCPIIPCLDCPYCHSSQYNMCTNLKEVGSTVNGGFAEYVGIPEQTIKIGGLVRVPDNLSDEEASLLEPLACCLNGLCQLGPFAEPRPAVIIGDGPVGLLHLQLFKNLVGAGAAVVGKVQSRMQKARSIGADAVFEYSENVASDILDFTGKAGAGTIVIATSSPSVFDLAGKIAGKNSKISLFAGMPNEQKFSIDANWLHYNQVTIVGAFSSLPPTLEEAAKIAEEGIVDLSQIVTHRYSLTEVEKAIQTTETCSGLRGVINKFPSLGKERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC5</accession>
    <name>K0IMC5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57774">
        <property type="protein sequence ID" value="AFU57774"/>
        <property type="gene ID" value="Ngar_c08320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08320"/>
    <dbReference type="HOGENOM" id="CLU_1881145_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-830-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="15265" checksum="53D51E5057039932" modified="2012-11-28" version="1">MKRRNNDVTTQTLHNEPKDILLMLQELGDKISFSILKSTIKKCKSVAEISRENNIPLSSVYRKIPDLQNMGIVAIETIVTDASTGKRIAMYRSKIRSVHFHLDENGAKLMFENNNNSSLTERSNNSRSVSTLITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD7</accession>
    <name>K0IMD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57824">
        <property type="protein sequence ID" value="AFU57824"/>
        <property type="gene ID" value="Ngar_c08820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08820"/>
    <dbReference type="HOGENOM" id="CLU_1387627_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-880-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="20410" checksum="1E8670095C85F21E" modified="2012-11-28" version="1">MRTIGPSVGLAFGLSAAGLGAILLVASFIPAGIIKAANHGGANEQFLQLHGRLDVLLYDESGRIKDERHIDNMIVDAGFEGIAYRIAPHDGTVTPSNPWNYIAIGTGNTATAAGDTALVSELVRIQDTQAEYSTSSKQLKLQVSFDPGVGTGNIAESGLFNAASAGDMLARQTFTTISKGASDTLTVTWTITLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME9</accession>
    <name>K0IME9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57849">
        <property type="protein sequence ID" value="AFU57849"/>
        <property type="gene ID" value="Ngar_c09070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09070"/>
    <dbReference type="HOGENOM" id="CLU_2406449_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-905-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10189" checksum="C90AD67DE1F778A5" modified="2012-11-28" version="1">MLVPCYWTDEVYSEDIAAVLVQLVVVISRIACCIYRTPGGRLDAIGTYSWLSNTLAGVKSAENGTIRLPLLDVMCSLYPNIHPLVWLKPHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG9</accession>
    <name>K0IMG9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase/methane monooxygenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amoC2</name>
        <name evidence="2" type="ordered locus">Ngar_c33570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33570"/>
    <dbReference type="EnsemblBacteria" id="AFU60272">
        <property type="protein sequence ID" value="AFU60272"/>
        <property type="gene ID" value="Ngar_c33570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3347"/>
    <dbReference type="HOGENOM" id="CLU_1444620_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006980">
        <property type="entry name" value="NH3_CH4_mOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="21203" checksum="459AC8F2FF802204" modified="2012-11-28" version="1">MAQMPALIPKEVEIQRLKKIYIMVIMLGSIAASVEVDNFVDGSLHQTTIRDSAFTPAHWWLYSHFVALPLGWGFVAMYDRRIPILRGPGNSMNTGLKLTIIGYLATMFTIGVNELWHFWFVEEVFAVPNHWMFNMGVVVAFMGALAYVVRVYARLVELGAETPARNPYVAEMYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML1</accession>
    <name>K0IML1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c34670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34670"/>
    <dbReference type="EnsemblBacteria" id="AFU60382">
        <property type="protein sequence ID" value="AFU60382"/>
        <property type="gene ID" value="Ngar_c34670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34670"/>
    <dbReference type="HOGENOM" id="CLU_022610_0_0_2"/>
    <dbReference type="OMA" id="HYYDIQH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3468-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="283" mass="31317" checksum="7CB6C73BB510106B" modified="2012-11-28" version="1">MPHMLKQVLGSVLTPEETAQVYSAFDQIGDIVIIKIPDELMPKKKLIADAILANVKTAKAVFAQVSPVRGDFRVRDLEFIAGENRTVTEYKEHGCRFKVDVAKTYFSPRLSTERQRIADMVGDNETIINMFAGVGTYSVVIAKANKTCKVYSIDSNSAASELDGINAKLNKVQDRVVTICGDAAEVIKDRLAGRADRVLMPLPERAKEFVDSAVLALKEKGIVHYFAHIKADSKKAGQELGLQDAHDAFAKYDHQVLAIRVIREVGPRIYQIVADVLVSSRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN6</accession>
    <name>K0IMN6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Ngar_c11120</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11120"/>
    <dbReference type="EnsemblBacteria" id="AFU58054">
        <property type="protein sequence ID" value="AFU58054"/>
        <property type="gene ID" value="Ngar_c11120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1054"/>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_2"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1110-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="282" mass="30809" checksum="CDDD69D5F0B66FC4" modified="2012-11-28" version="1">MTKRAPAVAGMFYPDNPRELRGLVDESFRNQRFGPGRAPPSANKRRIYGIVSPHAGYVYSGAVAANGFYEVSSINFQDVIMVGPNHYGIGSWVAAMKEGEWETPLGEVKVNSELAEGIAARSSTLDFDNFAHSRDHCLEVQLPFLQYIKQDFRIVPIVLVSQRSETAYDLGNAISETIVEKRVADSTLLIASSDFTHYEPNNEAHRKDAELIKAILALDVNKFYAVLERLDVSACGYGAIATMMVAAKNLGATRGELLKYATSGDITGDTSAVVGYSSIVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT6</accession>
    <name>K0IMT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58189">
        <property type="protein sequence ID" value="AFU58189"/>
        <property type="gene ID" value="Ngar_c12490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12490"/>
    <dbReference type="HOGENOM" id="CLU_1674042_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1247-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17906" checksum="43CEFABF4933104B" modified="2012-11-28" version="1">MLFTDDECAKFLKERYQEPVFCYGPYKVIGWSDDPAVLKWFMGVSLVRALKLLATKNKKFRDPVKKMLISVNHALEFDKDYFLHGLMLMTLSAPFVHPWAKKIVCDILGIKEAHFQKIKPAIDGALKGRNGLQFLEGLADSDSSMPSYVHVKDPLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY9</accession>
    <name>K0IMY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58454">
        <property type="protein sequence ID" value="AFU58454"/>
        <property type="gene ID" value="Ngar_c15200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15200"/>
    <dbReference type="HOGENOM" id="CLU_2067879_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1518-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="12370" checksum="7182A4F11D8B63A6" modified="2012-11-28" version="1">MKKFVGGLVLGAGLIIGTTIVFALKESGTTTTTIATTTASSSSSTQQKVTIRGSVGVPFAPINVYKDGKHFATVTADFEGNYEFTSDQPGTYTVKTDSSTQTVTVQSNSKTTIYQNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ1</accession>
    <name>K0IMZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58464">
        <property type="protein sequence ID" value="AFU58464"/>
        <property type="gene ID" value="Ngar_c15300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15300"/>
    <dbReference type="HOGENOM" id="CLU_2839493_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1528-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="6732" checksum="8EA53E3ED4927763" modified="2012-11-28" version="1">MMATEYCPSCNEAVLWKCSSCEKENDKSVHTYHPPRAESSRTASVVGTLLGLASGLYVIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN46</accession>
    <name>K0IN46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18060"/>
    <dbReference type="EnsemblBacteria" id="AFU58739">
        <property type="protein sequence ID" value="AFU58739"/>
        <property type="gene ID" value="Ngar_c18060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18060"/>
    <dbReference type="HOGENOM" id="CLU_1763930_0_0_2"/>
    <dbReference type="OMA" id="FERFFCC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1804-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="17141" checksum="85AF76907D336198" modified="2012-11-28" version="1">MPVQLDDTDVAIVKSLMEDGRKSFRAISREIKVSTPTVKARYERLVNMGLIKAIKPEIDLSKVDKKSKDEFDDTLESLKKQKKHFHVYVEGLKVKLKCEFCGGPIHGKPKVLKFAGFERFFCCTQCRVSYKDKHGGRIEMLKEQYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN79</accession>
    <name>K0IN79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58904">
        <property type="protein sequence ID" value="AFU58904"/>
        <property type="gene ID" value="Ngar_c19720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19720"/>
    <dbReference type="HOGENOM" id="CLU_1954732_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1970-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14577" checksum="68128D05E738A77A" modified="2012-11-28" version="1">MVDPVKGTVTKRTFTGKPLFIFFTTTWCTPCQIGAQNLAKYDDETGGSAFDVLIVFVDPREGDQQYVDWKGKYGRDDWYVAEGVGMATAYKVRYLDTKYVLDKDGKITWVDLNPLEYSKVKQVLARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA1</accession>
    <name>K0INA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59014">
        <property type="protein sequence ID" value="AFU59014"/>
        <property type="gene ID" value="Ngar_c20830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20830"/>
    <dbReference type="HOGENOM" id="CLU_1782436_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2081-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="14506" checksum="6E276C2A60D9B28F" modified="2012-11-28" version="1">MADIAIAAGLADELRDRLREHVHIDPYCLPDPFGDKDDCTYFVVLDRENLNRVVAMFVNKKENNLPQLPWSSILGERLAKVSISKEDAFALKHELMPKETNNFYPYRRNGRIAGYAMFAFQICGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ6</accession>
    <name>K0INJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59489">
        <property type="protein sequence ID" value="AFU59489"/>
        <property type="gene ID" value="Ngar_c25670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25670"/>
    <dbReference type="HOGENOM" id="CLU_775269_0_0_2"/>
    <dbReference type="OMA" id="SENWNTI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2566-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="348" mass="37652" checksum="E0A14F8B645CB011" modified="2012-11-28" version="1">MMNVPALLLLLLALSLLVVSAAPAYAHFDHLTHYNSRGGGVGQYYVYEALEPDYAAPGEPTAIMFSVQDYDGRDTYNIETMVEIYTSSGERIKAFPWTKQDVGDFQVFYTFPHVGSYQIVLSIADGPVNTNAIDLPRSTLGSTAGCNCERLIFNVAVSQGFGSIYNSTLGGAVFSSLAIFGAVLGLTYWSKKKSGKFASAPGDTMRYIVTLAAIAGGLVHFAVYSGHASLRLEYSIFLIVAGGMQVTYGILYTLLTLTGSTTGRARPHEHYRKTVAVNLFGLIGTAVLLGLYAYSVTLPPPLSPTGQPEDVDLAGILAKAVEVFTLIGIVYLMRLEKRRLQTFLKEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL3</accession>
    <name>K0INL3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c26520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59574">
        <property type="protein sequence ID" value="AFU59574"/>
        <property type="gene ID" value="Ngar_c26520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2627"/>
    <dbReference type="HOGENOM" id="CLU_081974_3_2_2"/>
    <dbReference type="OMA" id="WAEKWNH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2652-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13558" checksum="5747137E443EE976" modified="2012-11-28" version="1">MPPARRIRYVAQLYFMSEGEEEDYHKLSDKEIQQEVGKLDGWKVAGGKVNKTFEFDDFVQAFGFMTKVAMEAEKMNHHPEWFNVYNRVKIDLVTHDVGGISNYDIKLAKTIDRIAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU8</accession>
    <name>K0INU8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="9" type="ordered locus">Ngar_c30830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30830"/>
    <dbReference type="EnsemblBacteria" id="AFU59999">
        <property type="protein sequence ID" value="AFU59999"/>
        <property type="gene ID" value="Ngar_c30830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3055"/>
    <dbReference type="HOGENOM" id="CLU_035008_1_0_2"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="280" mass="31513" checksum="2D42945AF612CD2E" modified="2012-11-28" version="1">MARVAFQGERGAYGEMAALQYFPKARLAPKKSFQDVFDAAENSGSADYVVVPVENSIEGSVNEIYDLLLQTKMSVIGEVYQRVRHCLIANKGAKKIKHVYSHPQALAQCRGYVQKKKLEPVPAYDTAGAVKMIKENKMIDSAAIASRRAAELYDMQILDEGIEDRKNNYTRFLVLSPKKVSGKGDAKAGKYYHHYKTSIIFSVKHVPGALFGIIGEFAVRGINLTKIESRPTKETPWEYNFYVDFEGHVQDKSVQEALRSIKPKTSYVKILGSYRKADFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV6</accession>
    <name>K0INV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60039">
        <property type="protein sequence ID" value="AFU60039"/>
        <property type="gene ID" value="Ngar_c31230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31230"/>
    <dbReference type="HOGENOM" id="CLU_1248318_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3123-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="24429" checksum="45E86CBBBC29F7EF" modified="2012-11-28" version="1">MAKQLVPLSDRSSAFFLLASALLIGTFVPIADIIIMLDESAVAIKKVYAQTDDLWYVGEGVKQGMWVKYRIEELDTNNGRPYEMTIHFREQQQDGEWIAPVYVVFQGKVLQGTLRLGNNLAALGGSDIPEAMEPFIDGYRGSIQWLESFTQQSSPLSLRQPSWGKIAAIGGEEVRPLGEEQVTVAGGTFDATVIGWHRGQVDNRISVLGNNEFVSSFLVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY5</accession>
    <name>K0INY5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c32690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32690"/>
    <dbReference type="EnsemblBacteria" id="AFU60184">
        <property type="protein sequence ID" value="AFU60184"/>
        <property type="gene ID" value="Ngar_c32690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32690"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3265"/>
    <dbReference type="HOGENOM" id="CLU_007727_8_0_2"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3269-MON"/>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="4">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="322" mass="34828" checksum="F654E6904BBDECB5" modified="2012-11-28" version="1">MCQIAVFYGEALARYGFEGSHPFGTDRLGAFWSKLQSENVDNIVVEEPMLGTDQDALSFHDKEYVDLVRMASRHGGGMLLDRGDTPAFKGVFEASLYVIGSTLAALDMVVAGKDSKGRKIDHAFNPIGGLHHARRDTAGGFCVFNDIGVAILAARKKYGINRVMYVDIDAHHGDGVFYEFEDDPLLFFADIHEDGRHLYPGTGSASEIGKGTAAGTKLNLPLEPGAGDDEFIKAFDKVEQFVDGIKPELIILQCGADGLAGDPITHMQYSPAAHRYAADALHRLAHKHCMGRIIALGGGGYNRANIGAAWTEVVRSFAMAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP17</accession>
    <name>K0IP17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60344">
        <property type="protein sequence ID" value="AFU60344"/>
        <property type="gene ID" value="Ngar_c34290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34290"/>
    <dbReference type="HOGENOM" id="CLU_2340016_0_0_2"/>
    <dbReference type="OMA" id="YERAFFG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3430-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007457">
        <property type="entry name" value="Fe_traffick_prot_YggX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036766">
        <property type="entry name" value="Fe_traffick_prot_YggX_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04362">
        <property type="entry name" value="Iron_traffic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111148">
        <property type="entry name" value="SSF111148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10414" checksum="4FF2A66B7ECB4A84" modified="2012-11-28" version="1">MSKTCAKCGKIIEEIVDDPVADKYPACAACWKEWTTYAVMVMNEMRLDMSLPEHRKVLRKYERAFFGLEKGIGEIEKKPDNPESHHGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP44</accession>
    <name>K0IP44_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35660"/>
    <dbReference type="EnsemblBacteria" id="AFU60479">
        <property type="protein sequence ID" value="AFU60479"/>
        <property type="gene ID" value="Ngar_c35660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35660"/>
    <dbReference type="HOGENOM" id="CLU_551677_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3567-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="288"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="477" mass="52359" checksum="B1EC3105A6A06EF4" modified="2012-11-28" version="1">MDIATGSKYPQIPGISEFVDGTISSGLLLLLTGPAGAGKTMYCRQFLADGLLDGDYCLLVSSRLTEKQCRDLFSRIDPELVKNLKFVNPCASSSSRVDVIKNLSAILKDVRAAMDKASETGKSVRIVLDSLTHLLLFSGEKPLLKFTTDLSLILRDGPAMAICTLASEERLRRMLSAVAEGILEMKLEDNNGALDRSIRLFSIKGIHHEPTWVKFKIADNGELSFEGRASPVTLNCTLCGKAITGIPFTESDFVFDTKACMETYRKLADAYGSSISETGLPLEVFNVSFFFIDIVGLSDPSLSVRKQIQKIEALNRLIASCDAFKTSGGKRIILPTGDGMAIGFLLNPELPIELSIQLHRQLRAYNKGRVEEDRIGVRIGLGSGPVFAVTDMNNVQNVWGPGIILARRVMDAGDNGHILLADKLAEELIALKDEYRSIIKPICQSYEIKHGQKITLYSAYSHDFGNPELPVRVPRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6S9</accession>
    <name>K0I6S9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c00110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00110"/>
    <dbReference type="EnsemblBacteria" id="AFU56961">
        <property type="protein sequence ID" value="AFU56961"/>
        <property type="gene ID" value="Ngar_c00110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00110"/>
    <dbReference type="HOGENOM" id="CLU_2177956_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-11-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU56961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12088" checksum="5BBC3E45DE1C15CF" modified="2012-11-28" version="1">MSTDINNNTGNELALIAGSVVLSDNPSQQLKYWRKKFGVKQADLARKMDITPSVLSDYEKGRRPSPGVNFIKRYLIALYELGRSNSHAATTEEEKMAPTPVANVHISQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I784</accession>
    <name>K0I784_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01670"/>
    <dbReference type="EnsemblBacteria" id="AFU57116">
        <property type="protein sequence ID" value="AFU57116"/>
        <property type="gene ID" value="Ngar_c01670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01670"/>
    <dbReference type="HOGENOM" id="CLU_1830506_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-167-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="15816" checksum="616F0153A44DE818" modified="2012-11-28" version="1">MAGIRADYAVYYGAAASTAIAGILHLVTASNAVGLREITLAILFAIAGIAQIFYAWPLVRRWGRPWYYGGIIGTAILIILWIGTRIPSGRVLGGYTELLPINAVGIAVLIFQFAALLLSIRILQTATTPSKISRRGENKSDRDAAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I795</accession>
    <name>K0I795_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01820"/>
    <dbReference type="EnsemblBacteria" id="AFU57131">
        <property type="protein sequence ID" value="AFU57131"/>
        <property type="gene ID" value="Ngar_c01820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01820"/>
    <dbReference type="HOGENOM" id="CLU_045837_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-182-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="320" mass="35643" checksum="524BA85F920AA6EE" modified="2012-11-28" version="1">MATAPEDGKYRLFVIGQKQLPEIVEGRSTSEERNWALNVLATDKPEDIRKELLPTEYETETRGKRSVGPATPAGEGKYAIVKHDSHTELAYTLELPEVPGPTQKEFEIRKEVSYIVSVKNPDISIKGFAAFEKRKPKYPSSIKQKFGDKRWINVEDPDLLNYENAQVLLIGARQKDVQEELGIDLDEEKETANTTELFKELRIKREQVPLKPLLEGKFLGKGEQQPMAAETRQLSREEAPGRGGKIGGEAAASRAPSAAAIAKILSGIGFPKGKSDLVEYAETSKARVEVAEEIIQVIRELPDRTYNNMADVEKAVGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7J8</accession>
    <name>K0I7J8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methionine-R-sulfoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57216">
        <property type="protein sequence ID" value="AFU57216"/>
        <property type="gene ID" value="Ngar_c02680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.262"/>
    <dbReference type="HOGENOM" id="CLU_170464_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-268-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6464" checksum="7343E0FF37B5E92C" modified="2012-11-28" version="1">MEEEVDTSYGMVRTEVMRGRCGAHLSHMFDDGSNPTCPRYCINALSLLLAKKKGATTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7X1</accession>
    <name>K0I7X1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57361">
        <property type="protein sequence ID" value="AFU57361"/>
        <property type="gene ID" value="Ngar_c04140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04140"/>
    <dbReference type="HOGENOM" id="CLU_2285132_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-413-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11327" checksum="5D4EFBF175A3C091" modified="2012-11-28" version="1">MQIFSIFDIFAQSHHGFWWEVFSLGSAGLAVILLAIAIFAYKRHKLVRLVPLSAAFGLFILRVGLLHLDSLYPMLESELQVASVATDFGMLSMLFLAVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0I933</accession>
    <name>K0I933_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V4R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08740"/>
    <dbReference type="EnsemblBacteria" id="AFU57816">
        <property type="protein sequence ID" value="AFU57816"/>
        <property type="gene ID" value="Ngar_c08740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08740"/>
    <dbReference type="HOGENOM" id="CLU_1048143_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-872-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="197"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="29373" checksum="A1791D43234E2CFD" modified="2012-11-28" version="1">MQKADNNEKPRHWQDYDQIKRQVIEALENHAEGMTGAKIAEIVGVTQGAMSKYLSMMNVDGIITSRKVGVAKLWKLVSSADRTNLLADKLGSENVSFKDYALSLVENDGRLFDPDNKQVLVMHTIILLNLYKYTKSVLGSEVHAFFYEWGKSFTRETKDLVQSIAKRTGSNFISSFLSLLKLRGWGRFEITTMNERSVEVIWHDSIWSEVESETAPVDDFMVGALVEASSTSFGGNWMFTEVECRSMGASRCRFSGKRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA36</accession>
    <name>K0IA36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12310"/>
    <dbReference type="EnsemblBacteria" id="AFU58171">
        <property type="protein sequence ID" value="AFU58171"/>
        <property type="gene ID" value="Ngar_c12310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12310"/>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_2"/>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1229-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="407" mass="45034" checksum="9BFC791FCB47E5EE" modified="2012-11-28" version="1">MELAFTVANLVITAIMAGIFGMWVYFLAYMTKSFKKAPTLESFDRSGTTHSPKVSVILPARNEERYIARCLDSLLAQDYPNFEIIAINDSSTDRTGEIMQEYAAKDSRVVHVNAPPKPDGWAGKNWACYEGYLRAKGEVLLFTDADTEHSPSTMSLAIGQLVSQNLDALTAIPLLICNDFWTKITLPALETFLHTRFSPLRVNDPNTKTGYFFGSFFVITRSTYEAVGTHKGVRQELVEDGALGGKVKEHKFRMKMVRGESQIKAVWARDLQTLWDGLRRLMMPIYYQNRSGAYLMVIAVFFILFAPFALLPYLPAAAAASANNINNISFQLLLGIQLAAIALIFVATAVQCKLGVFESPLYALASPLGGALVSFGFLSAIVDAGNGGTVSWRDRQYTVSENQHPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAD9</accession>
    <name>K0IAD9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
            <ecNumber evidence="2">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnA1</name>
        <name evidence="8" type="ordered locus">Ngar_c13430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13430"/>
    <dbReference type="EnsemblBacteria" id="AFU58281">
        <property type="protein sequence ID" value="AFU58281"/>
        <property type="gene ID" value="Ngar_c13430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1299"/>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_2"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="104"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="468" mass="51837" checksum="C051B763F6844279" modified="2012-11-28" version="1">MTLKDSLEHSADRMGFEDAEFILIRYTDVPGRFLAKYIASDSGEYLRSGVAVDGSSVRGFAKIDESDLLLVPDKSTLRPAPISNYKVATVIADVHEGFGRGRLIRDPRHVSQLIEEHLAREGLSCQIGPEVECFVFDDIVFGGKSGPEILSAERAGKYHIRRKGGYDAPPFQDSLVELRFEVAEILKKNYLIKVTNLNHEVASSGQIEINFMHSTLTKAADNVQVYKDTVRNVAKKHGKIANFMPKPVFDESDPSSSESDNGSGMHVSTSLWDGASNIFYDASDGYAELSQTGRYFIGGILDHARSLAALVAPTVNSYHRMVPGFEAPIYAAWSRGNRSAVARVPVNDRNNVKSKRIEFRAPDPSANPYLAFSAIVAAGLDGMRKKIEPGDPVNEDIYKMPDHVRSSLGIRSLPGSLQESLEALKSDHDYLKPCFQGDLLETYVALKQEEIAYAGRSKERQFMLYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBV1</accession>
    <name>K0IBV1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58761">
        <property type="protein sequence ID" value="AFU58761"/>
        <property type="gene ID" value="Ngar_c18280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18280"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1826-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9650" checksum="5490E28AA5377F55" modified="2012-11-28" version="1">MTKDIKKKNRTRNDIIVEMLTSALEGTTKTRMMFYAYVSYTQLSKEYLPVLLKNELLAYDAERNRYFTTAKGCEYLRSYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC09</accession>
    <name>K0IC09_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58871">
        <property type="protein sequence ID" value="AFU58871"/>
        <property type="gene ID" value="Ngar_c19390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19390"/>
    <dbReference type="HOGENOM" id="CLU_1792191_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1937-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16261" checksum="E4538EC076CCE10D" modified="2012-11-28" version="1">MRIKDDKFYIGNSAQICHIFLRNITNDPPKTYQCKNNYDTTTHSSVKIMLEYSDKKAIALVLAGVAADLFPLVIDLYRFLLEGLHWHQETTQLIVVLTISALTGIIGVLVLYGAGVLSPFWKKSALRRRWLGRHVTIGILTDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICC3</accession>
    <name>K0ICC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS-center protein of succinate dehydrogenase/fumarate reductase</fullName>
            <ecNumber evidence="3">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdhB</name>
        <name evidence="3" type="ordered locus">Ngar_c21000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21000"/>
    <dbReference type="EnsemblBacteria" id="AFU59031">
        <property type="protein sequence ID" value="AFU59031"/>
        <property type="gene ID" value="Ngar_c21000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21000"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2080"/>
    <dbReference type="HOGENOM" id="CLU_044838_3_2_2"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="278" mass="31630" checksum="74A8FB5274452A97" modified="2012-11-28" version="1">MTEQVIEKIEKMEKKHEKKEKEIIRSSVVLKVYRANRRAGESAHYDSIEVPVQRWTTVLDALLYAKAYKDPSIGIRYSCRMASCGSCGMKINGIPRLACYTKVSELEGSTITVEPLANFPHIRDLVTDFSQFFAHHRSVQPYIQNDQADIKDMKKLSEFMQSPEDLDKFLQFSYCIKCGLCYSACPTVATDTKFPGPQALSQAYRYFIDNRDTGSKQRMNIVDDRHGIWRCHFAGSCSSVCPKGVDPALGIQLLRGHLLGFSNNEKKIADLQERLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICE6</accession>
    <name>K0ICE6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02870"/>
    <dbReference type="EnsemblBacteria" id="AFU57235">
        <property type="protein sequence ID" value="AFU57235"/>
        <property type="gene ID" value="Ngar_c02870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02870"/>
    <dbReference type="HOGENOM" id="CLU_1514545_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-287-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="19156" checksum="BD691478F1CFE709" modified="2012-11-28" version="1">MASNNILFFIALLLAATTIVSIPAAVAYAQEGMRRPMSGNSLDVLVEPQWSEDGQARFKVSFLRPGTDTIQVHIDYGFVIKQGGQEIFNAVPPGQPLLHTAEGVVTIPQTSSQPFKFPANGEYEIEVSVAGINFVPMNVETATFPVTVTPEFPVGAAGVIAAAVMTATTVALARYRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICI2</accession>
    <name>K0ICI2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59086">
        <property type="protein sequence ID" value="AFU59086"/>
        <property type="gene ID" value="Ngar_c21560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21560"/>
    <dbReference type="HOGENOM" id="CLU_1665407_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2154-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="19403" checksum="A9EC87B035F0B34D" modified="2012-11-28" version="1">MTRMVSARTFFARMNEGRSGWMTEGQLIKGCREFFVSNGYDQLEENKIFNRGERIFNSLLVGSKTAGDDNDKETIVAYFQPRMDRHDTRLLGHLESMLYDLLDNYENTNLMLVTDSLSYTPIVKVEELGVAIENLMDEGMFLLFLNERSGYALFDEFQKLTMPIPVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICU8</accession>
    <name>K0ICU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="2">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57490">
        <property type="protein sequence ID" value="AFU57490"/>
        <property type="gene ID" value="Ngar_c05470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05470"/>
    <dbReference type="HOGENOM" id="CLU_1567205_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-545-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="18771" checksum="641BCE81BEB0504C" modified="2012-11-28" version="1">MSENRISRRVVESYGRNKEQKLAFLEDSDIQLLGLNQQQQDCLVITGKRKASAWAYSMRYSNNSSQNGIGLDAAMRNIADVSIGDTVVIEKVTPLAGERVILKPVEEIIPGISARVMEYVPFAIKDNPLAVGERIWYSFDGTTFVFDVADVQPKNASAIVVSKNTKFAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICV9</accession>
    <name>K0ICV9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59191">
        <property type="protein sequence ID" value="AFU59191"/>
        <property type="gene ID" value="Ngar_c22610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22610"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2259-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10171" checksum="79E9F86B2AB1A8F0" modified="2012-11-28" version="1">MKYRSRTEIASRILESATGGVTKTKIMYKAFLSYAQLKEYLTVLEENGLLAYDKGEQTYKTTQKGLHFLNITNSLQGMMEGIPTTQGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICZ8</accession>
    <name>K0ICZ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23200"/>
    <dbReference type="EnsemblBacteria" id="AFU59246">
        <property type="protein sequence ID" value="AFU59246"/>
        <property type="gene ID" value="Ngar_c23200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23200"/>
    <dbReference type="HOGENOM" id="CLU_049311_3_3_2"/>
    <dbReference type="OMA" id="EAFMLVR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2318-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="26275" checksum="F1793D652D30C6B1" modified="2012-11-28" version="1">MNILAIGAHPDDIELGCGGLLIKAARQGHSVFMYTLTRGAASGDPEQRTKELMQSAKFIGAKALWIDNFEDTRLNVSSTDLINHIEFFINKADPDLIITHSLGDVHHDHRAVASSTIEAGRFIPNIMSYEIPLTKDFKPQVYYDISDVVDEKVELIKIFWSQQSKLYLKANAIKGLAEYRALQSRLNTSINYVEAFEVLKICFGKEFKLWKVPNDRIPKIAGATRPKEIIELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDJ3</accession>
    <name>K0IDJ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57730">
        <property type="protein sequence ID" value="AFU57730"/>
        <property type="gene ID" value="Ngar_c07880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07880"/>
    <dbReference type="HOGENOM" id="CLU_1318572_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-786-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23716" checksum="F1CF4D86FF7F005A" modified="2012-11-28" version="1">MSEYDMNYALTELKEQHPWLRKYYYHSKMLQMVAKQVAAAAIKVVAKGRKLSYRKDEDFNSFTYNQSGFKIENDRLVLSKIAGGSIRIVLHRQPVNVKQVTICRSKAGNKWYAVVACDVLRRLYSTIIRYVKPAVGIDVGITKFCHDSDNHVVENPQFLTKMLKPLRRAHRRVSRKQSACLPDCTNASITSAVTFYTSYPTITAAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDU1</accession>
    <name>K0IDU1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57900">
        <property type="protein sequence ID" value="AFU57900"/>
        <property type="gene ID" value="Ngar_c09580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09580"/>
    <dbReference type="HOGENOM" id="CLU_2366304_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-956-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10467" checksum="4D02B57C97C6FDB4" modified="2012-11-28" version="1">MYAPEIAMPKIVLLDGAYNNSADVINYLNWTGMKYIIRIAAPSSRASNRVMISSTEQGARGEGKKEQAAFRLVAVKGRDRGDRVRLLFVMSTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV4</accession>
    <name>K0IDV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c00480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56998">
        <property type="protein sequence ID" value="AFU56998"/>
        <property type="gene ID" value="Ngar_c00480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00480"/>
    <dbReference type="HOGENOM" id="CLU_1830647_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-48-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU56998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15313" checksum="2CCAAC8C1B6DB397" modified="2012-11-28" version="1">MSGRWDDEEKRYDQYREGGSGGGKRRIGARGIRRIILIGFAVLGVIMISFFASRAGLHVALHERGEAIGTVQVVTAQISNNSFDTLRNVTVQFGDNNPVQRIGDMGPFSGVLVSPEGDDYEFDRVIVTANDGALTVVKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDX9</accession>
    <name>K0IDX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57028">
        <property type="protein sequence ID" value="AFU57028"/>
        <property type="gene ID" value="Ngar_c00780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.80"/>
    <dbReference type="HOGENOM" id="CLU_862225_0_0_2"/>
    <dbReference type="OMA" id="INTPMRI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-78-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="359" mass="38930" checksum="A61244F3B75FEA63" modified="2012-11-28" version="1">MNVRKNTRKSFPKGSVLSGFAVFSILIILAALPIATFLVYLPSAEFASAQDSAERFNLNLSSDVFAPGDTVILYGKVIPEDAIVVRLFDPSGKVLRLETFTARSDGTITEQVFVWPEPSKQYPFGIYSLEVRSSIVPSDVKTFSVYYVDITGAGSSSGAPSSASLVVKLDAPTLVSTNSQFRIFVQVTYNGALVNAEDEQLSNLLGSSHIHFGDSTNATAISLSGRFHKLHEGLYYADVTLDRDGSYIMHSIAFHNGFLSHDSRVVVASSASIGSVQESVNRLNERLDVTNRSLDQTNASLNTTKNALTQFAQDTSSTIGQMRDASGQINGLILPILVLISIIIALQISLFARIRASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEB5</accession>
    <name>K0IEB5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59671">
        <property type="protein sequence ID" value="AFU59671"/>
        <property type="gene ID" value="Ngar_c27500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27500"/>
    <dbReference type="HOGENOM" id="CLU_1736471_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2750-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="16941" checksum="B9E07DBE40B1EC0F" modified="2012-11-28" version="1">MNKIWLKSGKKQAMEKLTEDILTKYEPLSGFEREILTKQSEIKGIDEKIDNLKATYAKEMNAIEDLLALHKEGIAHVDVIAFKQLVDDEGGNPSALKDKVKLHDSLSNITTALRKDIKDLETKNTLEPEVIALEGRRAAAERRAQEEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEL4</accession>
    <name>K0IEL4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divergent AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12500"/>
    <dbReference type="EnsemblBacteria" id="AFU58190">
        <property type="protein sequence ID" value="AFU58190"/>
        <property type="gene ID" value="Ngar_c12500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12500"/>
    <dbReference type="HOGENOM" id="CLU_646583_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1248-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="424" mass="48744" checksum="85BD633B82440504" modified="2012-11-28" version="1">MDWSEVQKLIGDLERVRVDYKETPYLEADPKDIAADLVAFANRQGRHILVGIKDDKSKEGKKINADESQLRILNIANNNCSPPVSLSFDFHSASDGDVLIVYVHRKKDMPHAVVERRGAEIYRRTYYVRSGGGKRLVDDSVLRFLFREQFELEIDTAASLCFWYDRSSPTQNIMEGVADYSNYMYAFLKRLNSSDLQQLLSDEKKMMAGLILEIFPYAFLLDLSWRFTFSWASRINRGSDVMSSFTPSRAADLPSSNITYKEIPLPSGPTLSKLSLDVAQVFRESPFQLKLPKGTTIEIENRSEDTFLTLKNPKFTVSIGMSISNWNEGLPYPVALPEGEDNDEKYAFVKFNMMFDADFNLPDVSDDLFEEHSKFVHTIEDTILNEWHWDVVVAKLKDRRIDNIQNNVRNILAYMENPDPEYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM9</accession>
    <name>K0IEM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59811">
        <property type="protein sequence ID" value="AFU59811"/>
        <property type="gene ID" value="Ngar_c28920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28920"/>
    <dbReference type="HOGENOM" id="CLU_2712974_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2892-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8226" checksum="3EFC8D7D9BAB4A7C" modified="2012-11-28" version="1">MENCGIDVPEYSRKTQLLIIDALDVYSNKEEDIVDLIEQFALYARRNGKGRVVIIGDLGAFRLIQKIDRLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IET3</accession>
    <name>K0IET3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="2">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29480"/>
    <dbReference type="EnsemblBacteria" id="AFU59866">
        <property type="protein sequence ID" value="AFU59866"/>
        <property type="gene ID" value="Ngar_c29480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29480"/>
    <dbReference type="HOGENOM" id="CLU_1544248_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2948-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="19321" checksum="C766D07C448172E1" modified="2012-11-28" version="1">MIKSVTLTVEREYRVDTGKSRIRIDYDSMNSISAATGDLVKIIATRRKNFIARCLPLYIKDHNRQIVRMDSIIRAKLGAVIGDTVSVSKADVEDNRYKKLILVPLHGAPANLDGRYIANILANTKVHRNDLVSIPLLGRKKTAVYRVKSILPASLSVMFIDSDPMTNIEISQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEW9</accession>
    <name>K0IEW9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb5</name>
        <name evidence="6" type="ordered locus">Ngar_c13780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13780"/>
    <dbReference type="EnsemblBacteria" id="AFU58315">
        <property type="protein sequence ID" value="AFU58315"/>
        <property type="gene ID" value="Ngar_c13780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1339"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="RTQKDFA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="200"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="31322" checksum="9F6A6AC375AB4050" modified="2012-11-28" version="1">MVTDNSSGEMFCGNCGFVVSERIEELGPEWRAFSKEEHEDRSRAGIPTSLAMHDMGLATIIGPVDKDASGKPLSASMKSTIERLRTWDSRSQVHEPVDRNFRQAFSELDRLKDKLAVGDAVIEKAAYVYRKALEKGLVRGRSISALVAAALYAACRDTETPRTLKDIANASNIKKKDVARCYRLLIRELDLKMPVVDPVKCVARIASKAGLSEKTKRKALEILKKAEEGKISAGKDPMGLAAAALYVACVMNGENKTQKDVAEAAGVTEVTIRNRYKGLKTHLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEZ5</accession>
    <name>K0IEZ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58345">
        <property type="protein sequence ID" value="AFU58345"/>
        <property type="gene ID" value="Ngar_c14090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14090"/>
    <dbReference type="HOGENOM" id="CLU_080344_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1407-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="278" mass="29389" checksum="941C574837D6221C" modified="2012-11-28" version="1">MFALIAGILAISMVAASIAGGQMLSAQAQNSDDPMPVDLECETGAEVCEQEIKNVVQSVVSTSGTATVKVIPDKVSVTIGVETRGETAEQAAAANAELMEKVLAALRDLGIPEDQISTNWYSVWPVYEMRSPPCIEIYPQPPECAPKNEITGYVASNSVTVTLDADEDVGKVIDTAVAAGATSVNGAYFFVSSERQEEIRGGLIADAIANARSRADKAAAAANMEITGVKSINLNDMYFPVIYKELAQADRGTSSSSTPILPGQQEISMTVQVTFRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF32</accession>
    <name>K0IF32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57413">
        <property type="protein sequence ID" value="AFU57413"/>
        <property type="gene ID" value="Ngar_c04690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04690"/>
    <dbReference type="HOGENOM" id="CLU_1544139_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-467-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="20192" checksum="940AB2CD7658FDD5" modified="2012-11-28" version="1">MKVDPEKLSFDLFSTSDNFSALDFTEDDGTDPLGIDDFIKNRVQDYLPNKLASIWTVRYESVIVAYFTTSMFAIGYRQLFDDEHVKEVPIVSYPAVLLGRMGVHKKERGRDIGYWICQFCIGLAQEIGKRIACRYIVLQTVKAKSTYYEKKCMFHQTKRVNLEGKIWMYRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF90</accession>
    <name>K0IF90_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57488">
        <property type="protein sequence ID" value="AFU57488"/>
        <property type="gene ID" value="Ngar_c05450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05450"/>
    <dbReference type="HOGENOM" id="CLU_168723_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-543-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12818" checksum="2D4DB331E491EA06" modified="2012-11-28" version="1">MPKKEFFVEGSKDFMKVYESLPRTSQLKKDIDNAISELKKDPLKGERIQQQLWPKEYVKKYGINNLFRYRLGGGYRLTYTIVGRPNGTTSVLLDALTHKEYDKLFGYSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFB6</accession>
    <name>K0IFB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57523">
        <property type="protein sequence ID" value="AFU57523"/>
        <property type="gene ID" value="Ngar_c05800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05800"/>
    <dbReference type="HOGENOM" id="CLU_2949111_0_0_2"/>
    <dbReference type="OMA" id="INMSSEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-578-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6765" checksum="E4EA5CC627A06AA4" modified="2012-11-28" version="1">MLEAKCPECGRKAQVNDEMSEVKCGHCGFSATYDDYIEIMKGKAVDIADNFQASWDRNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFC6</accession>
    <name>K0IFC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methionyl-tRNA formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c05900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05900"/>
    <dbReference type="EnsemblBacteria" id="AFU57533">
        <property type="protein sequence ID" value="AFU57533"/>
        <property type="gene ID" value="Ngar_c05900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05900"/>
    <dbReference type="HOGENOM" id="CLU_033347_2_3_2"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-588-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="2">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="3">
        <location>
            <begin position="207"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="358" mass="40598" checksum="FD2BE2F541A23D9C" modified="2012-11-28" version="1">MLRVLFLGTRQLGYEGLKAIIDKGHKVVAICTEDYAITEGYSYNHFQELAAKYGIPFFKTDKINNDKYYAIFKSLKPDIGVSLYWRRLVREPVVSLPRLGFINAHPADLPKYRGFAATSWSILLGDDITCMCIHKMVDNPQADVGDIYKKGYVKIDKNTTIKTLWEKLVPLTIKLTLEVMDELEKGTAKAEKQDESKAINAYPRLPRDGEINWSLSAVEIDRLIRAVTSPYPGAFTFYTGPFVENARERSDIRKKLFIWKAHVLENPPKFVGMPGHVVRLNDDGTVWVTTGNGILVLDEIQLDGGDIIKPTELLKSVQIRFGLEISEEIILLHEKIQSLRAEIAELKREKGVNSNQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFF1</accession>
    <name>K0IFF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60096">
        <property type="protein sequence ID" value="AFU60096"/>
        <property type="gene ID" value="Ngar_c31800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31800"/>
    <dbReference type="HOGENOM" id="CLU_2597867_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3180-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9064" checksum="9FD1C20D9E188DB1" modified="2012-11-28" version="1">MASVLEIQNVDYSLKLTREFLICDFCFWTASAITTRRHDIVACPQCDAAISRIPLAEKESFTFNYDKKRGVELDFAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFJ2</accession>
    <name>K0IFJ2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57598">
        <property type="protein sequence ID" value="AFU57598"/>
        <property type="gene ID" value="Ngar_c06550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06550"/>
    <dbReference type="HOGENOM" id="CLU_2152687_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-653-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12582" checksum="743008D6BEF996D5" modified="2012-11-28" version="1">MTSLIERIGNRTVLLDACVSPRLVKALRKAGLSVRHMNEIKPSMPDAHIEYLIMLPSDVLITHDTFFARFLGPKRAILLHRNEMDKIRQKDWCVEATGGIVDTKGSATRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFM1</accession>
    <name>K0IFM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60161">
        <property type="protein sequence ID" value="AFU60161"/>
        <property type="gene ID" value="Ngar_c32450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32450"/>
    <dbReference type="HOGENOM" id="CLU_1399783_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3245-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025238">
        <property type="entry name" value="DUF4184"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13803">
        <property type="entry name" value="DUF4184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="194" mass="20949" checksum="752EB3868B822894" modified="2012-11-28" version="1">MLKPGLGRLSFAAMTVGAMIPDIEPLVAWIFGWSVFCGWDFPCSPAPDRLVLHSIVGALTVDVALTILFVKILGRLLKVGRLGIRGFDRVKIMDVSLYVSAAIGALSHVLVDWLHHPANPIFWPFLVNGSYYVGGLLLQFMGVLPASALVAAVSSAIMVATVNRALNKSGHNFWLVLSNPPKALMLITENLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFU7</accession>
    <name>K0IFU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33510"/>
    <dbReference type="EnsemblBacteria" id="AFU60266">
        <property type="protein sequence ID" value="AFU60266"/>
        <property type="gene ID" value="Ngar_c33510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33510"/>
    <dbReference type="HOGENOM" id="CLU_2115559_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3351-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12550" checksum="149DAB235921A27E" modified="2012-11-28" version="1">MQSQLLQEYRSSAGLTDNSGLILYASNQSLIGSYYHDDKFQSILPGPVRSQFNALLDMAVAGESGIEDVRYLGSNYDSVPACNSKRQAPVDGIHHLPSRTHNRCRLPARAAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG31</accession>
    <name>K0IG31_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Ngar_c34510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34510"/>
    <dbReference type="EnsemblBacteria" id="AFU60366">
        <property type="protein sequence ID" value="AFU60366"/>
        <property type="gene ID" value="Ngar_c34510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3449"/>
    <dbReference type="HOGENOM" id="CLU_018693_3_3_2"/>
    <dbReference type="OMA" id="EIRCAKV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3452-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="74"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU60366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="31797" checksum="17462238E125778D" modified="2012-11-28" version="1">MIRCTFFMLSDPDEQLPREERQKAIDRADRRLSRRERESRLLVKRSEDYEVFDNVFDVPTLMIINDLRSDGVIQQVRGSLAAGKESKVYTATAPDGSLRILKIYLTVSAEFKKRMQYIAGDPRFSDIKRGSRSLIAAWARKEFKNMQAAYAAGVRVPAPIAVKKNVLVMEFVGDSEGNSAPPLVESEVTSSDYKQVIEQMTMLYQKARLVHADLSEYNIFKTDRGIMLFDFGSAVDIQHPNSKQFLVRDVMNVNRFFEKRGIEVLDTALAVEKIRGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG85</accession>
    <name>K0IG85_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34980"/>
    <dbReference type="EnsemblBacteria" id="AFU60411">
        <property type="protein sequence ID" value="AFU60411"/>
        <property type="gene ID" value="Ngar_c34980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34980"/>
    <dbReference type="HOGENOM" id="CLU_031477_4_0_2"/>
    <dbReference type="OMA" id="IGAHIYF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3499-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="PTHR31303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="21598" checksum="AD1C47C6EC917105" modified="2012-11-28" version="1">MGSNGRYALIRKELFRKAIHIFGFSIPFISLVAGVYYAAAIIIALAAVYSVSEYFRLKGRSFPVLTAVTKAAMRNAAEGEEEKQDTFVKAPLYFAAGILASLLMFPAPFNYATIAVITLGDGFASIAGRLYGKNKIPYTCGKTVEGSLAGFVCAFAGAAIFISPATALIAATIGMVIELLPLRVTDNLTVPLLSGLTISIIGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGE1</accession>
    <name>K0IGE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c09560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57898">
        <property type="protein sequence ID" value="AFU57898"/>
        <property type="gene ID" value="Ngar_c09560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09560"/>
    <dbReference type="HOGENOM" id="CLU_040997_0_0_2"/>
    <dbReference type="OMA" id="KTHQFWA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-954-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="194"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="370" mass="42797" checksum="639D548F599C258F" modified="2012-11-28" version="1">MRADTVYSSLRKSRYESWNVLPSILPYSGNEANYQRRQAFLKKQKKLPNYSQQCRHFKHSDNFKAIGTGKGQAVLKKLDEAWSSFWTLKRLQSEEGRLPPNIRRVRMPSYLKDRDSKQTVVRGFYVRNDCYRLDRKRSTITIIGKNLRLRYAADRVREGKKGRLDVMYDRLKDAWYAFIPVDTAPAKQAVVSGQPEKVGSIDLGICNLVAFYAENEQPVIYSGRAVLSDYVYRTKKIAELQSRLPQKQQHTSRKIGLSYRKRTRRFKHATRAMLKDLFERMKQIGITKVAVGDLNGIRDGNNLGAHTNQKLHNFWSHLQTIEWIRHMCEDYSMEFVQVSEKGTSKTCCVCAVKDIMAGYIEACTSAKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGV6</accession>
    <name>K0IGV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11370"/>
    <dbReference type="EnsemblBacteria" id="AFU58078">
        <property type="protein sequence ID" value="AFU58078"/>
        <property type="gene ID" value="Ngar_c11370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11370"/>
    <dbReference type="HOGENOM" id="CLU_2165345_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1135-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12172" checksum="849A4D344995F1AA" modified="2012-11-28" version="1">MMIVVPSAAGIAYGHGIQSGPVGRPIRIDNEQFSDNTVTTDDVVIITGEIRSVVDRPVKLVPHIYVDHDAVPPYTNVLATIYPPLKNQSIWYFRVEHNLPNPTVLGPRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX8</accession>
    <name>K0IGX8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rps19e</name>
        <name evidence="5" type="ordered locus">Ngar_c01220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01220"/>
    <dbReference type="EnsemblBacteria" id="AFU57072">
        <property type="protein sequence ID" value="AFU57072"/>
        <property type="gene ID" value="Ngar_c01220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.124"/>
    <dbReference type="HOGENOM" id="CLU_108559_1_0_2"/>
    <dbReference type="OMA" id="YIDGPVG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="16904" checksum="97260903D9E78B06" modified="2012-11-28" version="1">MAKVYDVPADELIAKLAEQLKDDKKIVPPAWSAFVKTGSHATRIPQNKDWWYERCASLLRKIYLHGPLGVADLKVAYGGRKKVGYNLAHHRDAGGAIIRKALQQLEASGYIVKVQGKGRLISSEGMKKMDRLATEIHRELIKAAPQLQRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH68</accession>
    <name>K0IH68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58183">
        <property type="protein sequence ID" value="AFU58183"/>
        <property type="gene ID" value="Ngar_c12430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12430"/>
    <dbReference type="HOGENOM" id="CLU_2230464_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1241-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12525" checksum="A8F2DC2C997EE1E2" modified="2012-11-28" version="1">MTRKSKRTQPLSLKDRDIKRRHDRHIRKLIRGNETLRGLYMDPDVAKYSAEIESLLEQFYFSGMAWGWTLRDGTCKKVDARILMQSSHFFAFSRMPRTVQIRIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHD4</accession>
    <name>K0IHD4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58313">
        <property type="protein sequence ID" value="AFU58313"/>
        <property type="gene ID" value="Ngar_c13760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13760"/>
    <dbReference type="HOGENOM" id="CLU_1307818_0_0_2"/>
    <dbReference type="OMA" id="PGAVYWI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1374-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="229" mass="25941" checksum="F1CC18C9A341D591" modified="2012-11-28" version="1">MSSTSQPDNNNNNSQEAAASPPLIITKKDKIAAVADEIISLDKNIGNTLIEVLKRVAASDRSHVYWTCKKYLQDDYGLLIADSGHVGISDRYIPNLMFPGDIIIYTVVDMLCTGDYIQVLQMTDVKDLVVEHVRVTKVSIIDGAVNVEDPLSGSTYNVAKHNVIGKVVKVITAFSQEWENVFYEFKDRKWLLTTLKKNLDLYRNTCYSNQRQIVSEIERRLSKLKEEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF6</accession>
    <name>K0IHF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02740"/>
    <dbReference type="EnsemblBacteria" id="AFU57222">
        <property type="protein sequence ID" value="AFU57222"/>
        <property type="gene ID" value="Ngar_c02740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02740"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-274-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14509" checksum="E9714AE27DECBDAD" modified="2012-11-28" version="1">MTIPKKVMIIDDEPDVVAAIQNSLKNNGYKANGFTDSRKALEEFRNNSQEYALIISDIRMPGMSGFDLARRAKGTRPDVPIVLMSAFEINKPEFSSLFPSMSVSELVTKPMTKALLLAMVRKYVGITELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHH9</accession>
    <name>K0IHH9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58358">
        <property type="protein sequence ID" value="AFU58358"/>
        <property type="gene ID" value="Ngar_c14220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14220"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1420-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9468" checksum="5AC0201C4608A97E" modified="2012-11-28" version="1">MKYRSRTETIAQILGAAKGGTSKTKIMYKAYIGYEKLIDYLELLIDNGLIYYDDKTKVYVTTHKGLLFIEKYIRMAELMGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHI4</accession>
    <name>K0IHI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c24710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24710"/>
    <dbReference type="EnsemblBacteria" id="AFU59395">
        <property type="protein sequence ID" value="AFU59395"/>
        <property type="gene ID" value="Ngar_c24710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24710"/>
    <dbReference type="HOGENOM" id="CLU_1237950_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2469-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="bPH_3" evidence="5">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24886" checksum="BB43A09061E8E198" modified="2012-11-28" version="1">MTIEDIDPDIRGILLPGEQIIFIASQSKVAPGGSFLPNSIYITNIRVIFKDPRWFGLKVDIMDISYRDISTVMLKRGVFTTELYFKPHFTDYKVKLPALEKKAAQRISQLIQRGIRGELPGQNQLTIPDISAVQTVEQAAAAEVQPVEKEEKKPAQSADNTTASCRYCNFTVQPASKFCPECGKSVQIETNIFKVCPSCDAVTSDDAIFCSTCHQKFPDNFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ4</accession>
    <name>K0IHJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58373">
        <property type="protein sequence ID" value="AFU58373"/>
        <property type="gene ID" value="Ngar_c14370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14370"/>
    <dbReference type="HOGENOM" id="CLU_862259_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1435-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="322" mass="33065" checksum="647D0C966D49EBBB" modified="2012-11-28" version="1">MKKAPIAVALVLVFGLFAAAVSLAPAVAQNTTAPDGNVTTPGGNVTDRNVTGGNVTAPENETAVAGAETFSARGSIATLIFDTGEITTTGEMQNETGTTTGNETGLTTGNETGAAGNVTTSDNMTTTLPQIMTGGTDENTTLTADNETTTAQELEPPYVLAGDWSLDVQDGSVNNFAANFTMVHIDGTNRHTHEFSNFVSNNSTTIDTSGNGTSFIMGTVDISVDGETRWTGADALIIIERNNVISISVATEDTEDHFKGQPIYGIVESMTDENGNELIETGGAQAETAGNATGTGNQTGGNQTGGILENLTEGLQNLTGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHM4</accession>
    <name>K0IHM4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58418">
        <property type="protein sequence ID" value="AFU58418"/>
        <property type="gene ID" value="Ngar_c14820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14820"/>
    <dbReference type="HOGENOM" id="CLU_2766235_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1480-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7364" checksum="DA94CABAD8CF6D4F" modified="2012-11-28" version="1">MYVILPEIVLTVAVAAYYFDDTSTNNPASLIQSSIIPNAIGMGLFGFSIYLVITGHNSITGSTTSQLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV2</accession>
    <name>K0IHV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c15950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58528">
        <property type="protein sequence ID" value="AFU58528"/>
        <property type="gene ID" value="Ngar_c15950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15950"/>
    <dbReference type="HOGENOM" id="CLU_992539_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1593-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="280" mass="32722" checksum="9415CFC2569D09B2" modified="2012-11-28" version="1">MSSANIKCPICSKTLETAEYEHVKEQLGKSVSQKYREQLRKERQEHADRLARFKKEQQKRIQAMAKRQQIGKKLLQKRLSEQARVSKERYKRGLVQLKKNYQMQLEHLREFYGTQNAALQNELKASFASQLEAMKKNYESLSASNQQQLETLQKYLEDKLVGELREKVSQLEQDKLATELRLAEVVRQLDERNAEIVSMKERLPNMDTLTPEEHEVDQITSEAPEQAANQELIKMVREVAQQQELGELKELEEGGEEDGDQEEEKHRFWGSKAGKRFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHW8</accession>
    <name>K0IHW8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59530">
        <property type="protein sequence ID" value="AFU59530"/>
        <property type="gene ID" value="Ngar_c26080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26080"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2608-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11371" checksum="AB24C715E9479DED" modified="2012-11-28" version="1">MRNRQKDEIMRDILYSAQGGAGITKIMFHAYLTHGQAKEYTQLLIKSGLLEQDLETGSLRQFRTTPKGIEYLGAVERMSDMLAIETRRAAKPDDASPLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0II42</accession>
    <name>K0II42_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59600">
        <property type="protein sequence ID" value="AFU59600"/>
        <property type="gene ID" value="Ngar_c26790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26790"/>
    <dbReference type="HOGENOM" id="CLU_2056128_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2679-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="12580" checksum="7DB3D9CCBC41EB0A" modified="2012-11-28" version="1">MPLSPVVAVLAAISIVGAIAIPFGDPQFIDRAIALELAFIVLTVLTYKGFRKALYACIPLAAIVMVGNSLAPPHVGIMTTFSKPFNAMLLIIGGYVLQTALIVTAVRELKACRIVQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0II51</accession>
    <name>K0II51_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57662">
        <property type="protein sequence ID" value="AFU57662"/>
        <property type="gene ID" value="Ngar_c07190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07190"/>
    <dbReference type="HOGENOM" id="CLU_2597859_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-717-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9441" checksum="60CC0D8AF8701C01" modified="2012-11-28" version="1">MSIKDTLLHIIWAEDSWINYSIRGLEDLRRPFPFKDYQSWEAIIDYNDKVVAQVNEYLSELAEPELGRKVWRVNNDGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB2</accession>
    <name>K0IIB2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">bioA</name>
        <name evidence="6" type="ordered locus">Ngar_c17550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17550"/>
    <dbReference type="EnsemblBacteria" id="AFU58688">
        <property type="protein sequence ID" value="AFU58688"/>
        <property type="gene ID" value="Ngar_c17550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1730"/>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_2"/>
    <dbReference type="OMA" id="VAVKMCL"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="445" mass="50389" checksum="F518AD11C1AC17A5" modified="2012-11-28" version="1">MNLRDADKKFVWHPYTQMSDWKKWNNRVIVKGEGFYLVDSEGTRYLDGIASMWCNVWGHGQNKVVEAMTEQLKNLQHSTLFGLANGPSAQLAEELVVRAKGMDRVFYTDNGSTAIEAAMKMALQYWRNKGRNAKKGFISLEHGYHGDTIGTMSVGYIEKFFGAYKPLLTRVHRAPSPLLYGSRFENEKDLVDWCLEKTEKLLKKRGDRTAALVMESGAQIAGGAIIYPDGYQRKVARLCRDYDVLLVLDEIATGFGRLGSMIEYLAQRSKPDIVCFGKALTAGYFPLAVTLTTDRIFDAFLGKYSENKHFYHGHTFTGHPVGCAAALANIELYEKQNLMQQINENGKYIASRLREFVRSPIVADIRHKGLLAGIELARNNKPIVTLKNKERINYFIMQESLKMGVHLRPLGNIMMVIPPLAIGRKDLEKLLDVQLEVLRKVEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC5</accession>
    <name>K0IIC5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08350"/>
    <dbReference type="EnsemblBacteria" id="AFU57777">
        <property type="protein sequence ID" value="AFU57777"/>
        <property type="gene ID" value="Ngar_c08350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08350"/>
    <dbReference type="HOGENOM" id="CLU_666694_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-833-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="412" mass="45257" checksum="6648F144AC0D1F20" modified="2012-11-28" version="1">MKRNEKLNYKYRRSIIVVGAAAAVFLALSWGTYPHSFAAQHLQSENNLPPNDENKTTMSSITTTATTTADGTTGVANATAADMPNATFVEFVSNIEQIRGHLDQAVANKESGNDTLTQAHTLHPIGEVYSSIEVLLANQNSTLNQTLSEALKDLSSNVATTSVQQFENQTRAIDMILNQTVQAVIPTFELNNTAFNASVVARLLDIAGHEYEEAVANGMIKEIVEYQDAQAFIHRAEAIFNSTSDTIDEAMAHEVQEVNEFFAVLNSTVDSKGDPQTVETTINGIIHELEEITGFSSSQLLGGEEAGTTAEEQDPIAIINNIKSLLDKLLSAYQSQNYDEAESIAIEAYLENYEHIEAPIAEHDEQLMLQTETMLREELRQMIEDKAPVDQIQQHIANIEANLDKAASLLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR0</accession>
    <name>K0IIR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Ngar_c10500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57992">
        <property type="protein sequence ID" value="AFU57992"/>
        <property type="gene ID" value="Ngar_c10500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10500"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="RIGNPRH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1048-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="161"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="274"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFU57992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="392" mass="46273" checksum="CB6C04D28C06C022" modified="2012-11-28" version="1">MLNYKFRLYPTKEQELVLDQTLDGCRWIYNYFLSIPPMSEYDMNYALTELKEQHPWLRKYYHSKMLQMVAKQVAAARKAAKGRRSYRKHDDFNSFTYSQSGFRLENNNRLSLSKIGSIRIVLHRKPVNVKQVTICRKNSKWYAVAACQLLRRMYSTLIKYRKPVGIDVGITKFCHDSDNHVEDNPQLLTKMLRPLRKAHRRVSRRQTGSSNREKARHMLARLYERIHNKRHDFLHKTSTMYYSSRYDLIFLEKLRVMNMTKNHRLARKILDASWSTFKNMLQYKANRVVEVEPAYSSVDCSRCGHTVPKSLAVRTHSCPKCRAVLDRDYNAAINILKRGRESLMMLSLLLLLLLLRYYRWNAGKLHACRDRTTAVAEAGTRRGYRTSPIVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ45</accession>
    <name>K0IJ45_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58182">
        <property type="protein sequence ID" value="AFU58182"/>
        <property type="gene ID" value="Ngar_c12420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12420"/>
    <dbReference type="HOGENOM" id="CLU_1145251_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1240-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="242" mass="27866" checksum="5980C67710C3657A" modified="2012-11-28" version="1">MSAGNVERTHMEIPSIELSERTLTDICTIIDEQRQQIDGEEPRVTYTVKEKTRDFVTHNSEDFIKHAITRELGRIEIWYYHSKRKIRIDLVVKSYGHSDFTVEADNRIWVDGITRRLEGVFRSYKTNNDLFHSRWKSAIPIYIGLGVLLGVTILLVGSSFIPIISEDGEDNTLAAWTFIGGFVGAWSILGWNGLFEWLFPEVETEYTPQKKYRKRLLTVISTVLGTISLGLFVNYLFAILQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA3</accession>
    <name>K0IJA3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">leuB</name>
        <name evidence="2" type="ordered locus">Ngar_c22430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22430"/>
    <dbReference type="EnsemblBacteria" id="AFU59173">
        <property type="protein sequence ID" value="AFU59173"/>
        <property type="gene ID" value="Ngar_c22430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2223"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_2"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="342" mass="37135" checksum="16976877090BC97C" modified="2012-11-28" version="1">MTRYNISLIRGDGIGPEQAEAAKKILETISDKSSSTKFTISEVDAGDSALAKQGKALPESSVDTIKKSQACLKGPVGESAADVIIVLRRMFDLYANVRPAKSYPNIPSLSDKVDLVTVRENTEDVYLGWEFNADENTVVALRVTSERASRRIAEYAFKTATLRNSKRRVVAVHKANVLRKGDGLFAATCREVAKKYPKIQYSELYVDACSMNLIRNPEEFDVIVTTNLFGDILSDEAAQVVGGLGMGPAANIGDSFALFEPVHGAAFDIAGKNAANPSSILLSAKMMLEWLGDRHGDKDVIMEGKRIEDSIVGALKKGSKTKDIGGRLSTTEFTELVAKSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF1</accession>
    <name>K0IJF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-aminoadipate lysW ligase LysX</fullName>
            <ecNumber evidence="6">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysX1</name>
        <name evidence="6" type="ordered locus">Ngar_c14560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14560"/>
    <dbReference type="EnsemblBacteria" id="AFU58392">
        <property type="protein sequence ID" value="AFU58392"/>
        <property type="gene ID" value="Ngar_c14560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1420"/>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_2"/>
    <dbReference type="OMA" id="WKTNMAL"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="109"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="298" mass="32638" checksum="074EFB30D4D34340" modified="2012-11-28" version="1">MRQEKAGQSSQSNFSGNSLTILYDSIRWEEKALYEAAKKKGVSVENVDCKNLVVNLNSGRSKYNGQVVLQRSVSYFKNVHSTAALEGLGACVINPLNAAILCGNKMYAHMELEKAGVRTPKAVAAFSEESALAALEELGYPAVVKPTVGSWGRLIALLRDKEAAKAVIEDREHMFPIYQVYYFEEFVERPPRDIRAIVVGDRVVAAIYRYSGEGEWKTNMALGGHAEACPVTKELEDICLKATRALGGQIVGVDLMESKSDGLMVHEVNNTTEFKNTVRVTGVDIPGLMVDYALGQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG7</accession>
    <name>K0IJG7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">Ngar_c23780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23780"/>
    <dbReference type="EnsemblBacteria" id="AFU59303">
        <property type="protein sequence ID" value="AFU59303"/>
        <property type="gene ID" value="Ngar_c23780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2350"/>
    <dbReference type="HOGENOM" id="CLU_008831_0_2_2"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="180"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="30035" checksum="CD5FE2FDFE67BF97" modified="2012-11-28" version="1">MVSNIRRAAIITKMDSSEASAAASKVARLLGESKVKVYSVLPLEVTGAAPVSQEKLKDTELDLVFAIGGDGTTLRAFRTIPSKVPLFSINSGGHRGILSEIGADSIEQAVHAILGGKYFYDSRTRIQATINGKVLPPALNDILITRVSLTRTPLVSIKLMGDEIKQRMDGIVVSTPTGSTGHSFSIGGPVLHEGMSCLILSPIASVNRMPQLVIPVEDIVVQSTYESHIIIDGQETFRVDADKPIKIFRFPDDATFLRLQKKGMRQLAKLGFSKFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI6</accession>
    <name>K0IJI6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32600"/>
    <dbReference type="EnsemblBacteria" id="AFU60175">
        <property type="protein sequence ID" value="AFU60175"/>
        <property type="gene ID" value="Ngar_c32600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32600"/>
    <dbReference type="HOGENOM" id="CLU_324078_0_0_2"/>
    <dbReference type="OMA" id="ANIESWF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3260-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="654"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="880" mass="98697" checksum="260C7A736D2FF016" modified="2012-11-28" version="1">MDSPAKFNIGQAIDGTKFELDRASLTKHAIILGATGSGKTVLSKVIVEEAALQGIPTFAIDPKGDIGNLAFKSVSFDFSTWSGKEADALKIDRAKYAASLQKTYRDKAAEFKVAPNAAANFDKVTVRIFTPKSSAGLAVGISPDLSAPKDFNQLLSTDIASAADLLDLTSFNLLRLAGYGESDRKQVTFVSAILENAWKNGESLTVKDLIRNIESPSFSYVGSLPVSKVVSDKERKDLVTRINLLISDPKLRSWSSAKSINFSELFNSPSINILDLRNIQSEQEKHLFVELILQQLFQWLIKQGSAQTLRYLLYFDEIAGYCPPVREPPSKKLLLLLIKQARAFGLGMLLASQNAVDLDYKVISNANVRFIGRLGAHRDIQRVSVGLELDSDAEREIARLRPGEFFCNTFDPKFRGVIKSRWTLTYHRGPLENSEIAQLMAEFKKSEPVAEKEEEGREEEPIIEEEPEKPARLLLPVVAHEDPIVLAASDDETFLLLEKKFEPKDLSSFIKLGSNLRSIKVLSVEPEERFYPVFELNVSVFEKGYAKQSLDKIVEFAAIGDDDGLVDIPEEHIITSHRLVPAETRKEAEAWKGEIQKAVNRIEKELRHKFDILIEEKRKENIAARSEKPRAKIANIDEKVAKLQQSINTDIDTVKEYEKLYKDVKKESKKKKSLKPRLISIENRIDTNKQRILSTRRKIEQLHTNRKALEDELKDIQHEEKERFHQALGNIKSKTSFGITGWLVETVYRARILVNDSKEHYGDVMWSAYTGQGTWGRCSSCSVALAEGSICSCGNLLCSTHLAYCKMCLEPACMEHRAICYICSSTFCAAHYIRCEICRSPACANHSGTCSICNRKVCSNCSQKKGLIKSKIICRGCSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI8</accession>
    <name>K0IJI8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c24290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59353">
        <property type="protein sequence ID" value="AFU59353"/>
        <property type="gene ID" value="Ngar_c24290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24290"/>
    <dbReference type="HOGENOM" id="CLU_137479_3_2_2"/>
    <dbReference type="OMA" id="EYETNPM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2427-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11226" checksum="8D16CF5039384084" modified="2012-11-28" version="1">MTVHAEISIVPLGRHDTSMSKEVAAAFDAIHKIKNLKTKLTALGTQVEAKNLDSVLQAVEAAHEAAKSAGAKRVISTVRIDERLDKAQTLQDKVKSVKRKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM7</accession>
    <name>K0IJM7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58482">
        <property type="protein sequence ID" value="AFU58482"/>
        <property type="gene ID" value="Ngar_c15480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15480"/>
    <dbReference type="HOGENOM" id="CLU_2730541_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1546-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8040" checksum="42837E600AA3F252" modified="2012-11-28" version="1">MSTLLAAIKPSALVGIDGLWILNHLVLGLYHAPVAKAQFRGQYLHMVRPHFLIYMSKMQALADQMFMNQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJW4</accession>
    <name>K0IJW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60400">
        <property type="protein sequence ID" value="AFU60400"/>
        <property type="gene ID" value="Ngar_c34860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34860"/>
    <dbReference type="HOGENOM" id="CLU_3057254_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3487-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6474" checksum="8767FBCD38BA33FC" modified="2012-11-28" version="1">MINYAVKADFPKKHFWTLFIWKDRDSMRRFVMAKPHATAMKKFEEWQATVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX5</accession>
    <name>K0IJX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59528">
        <property type="protein sequence ID" value="AFU59528"/>
        <property type="gene ID" value="Ngar_c26060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26060"/>
    <dbReference type="HOGENOM" id="CLU_2857215_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2606-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="6925" checksum="5B7D11D9B034908A" modified="2012-11-28" version="1">MEDEIGGENTVQVNYQHGSREIVITGTNVVPEFPLHVVGAIAEAIGIMIVAILTRSTLLSKKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJY6</accession>
    <name>K0IJY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58587">
        <property type="protein sequence ID" value="AFU58587"/>
        <property type="gene ID" value="Ngar_c16540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16540"/>
    <dbReference type="HOGENOM" id="CLU_2949423_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1652-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6460" checksum="46A9269A4897D2E5" modified="2012-11-28" version="1">MIVFHAKNTVSLSGKIVHKAYSFIGSQSHIQRAAPVQQTAIPKPVLGCANKPFYYSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK05</accession>
    <name>K0IK05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1264 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35420"/>
    <dbReference type="EnsemblBacteria" id="AFU60455">
        <property type="protein sequence ID" value="AFU60455"/>
        <property type="gene ID" value="Ngar_c35420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35420"/>
    <dbReference type="HOGENOM" id="CLU_1399784_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3543-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="entry name" value="PTHR31360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="194" mass="21509" checksum="39014DE523EFAE23" modified="2012-11-28" version="1">MIATVAAILIGGVMSFQSSIAANDSNSESPTEGFNIHVTVNKHDSENLDHDMDHYCKLDDKIVAVCLLFDGTDTKAHLAQVEFIITDEQYQQLPEKEKFNWHNHAVELTPERGEPQIISLPEGVDGAALLDTLKHTYGKVVTLWDPSDEVPDFPPYVFAVDSPHALGQDENDDLECEWPEAGKEITESCGEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK55</accession>
    <name>K0IK55_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59608">
        <property type="protein sequence ID" value="AFU59608"/>
        <property type="gene ID" value="Ngar_c26870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26870"/>
    <dbReference type="HOGENOM" id="CLU_1352149_0_0_2"/>
    <dbReference type="OMA" id="HTHESVE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2687-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="23085" checksum="C2C373BCBF8441E4" modified="2012-11-28" version="1">MAATGRRSDVQGYVCTPHDKQSSSLVENWKKSDNVVDIYFVTATFSDESIPYFPNKANHYILASFINMESILDDIKKYNMDRLSFMFSFSSPLFERSGNKLNYVSLYFTKYTSGDPAISDLANTIARREKVKKASLAQMQLVAAEQPKFTFPYSRNLVILEVEGEATHQTDQKYCERTRRDVARKGIALNNLVSFSILEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI6</accession>
    <name>K0IKI6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c28690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28690"/>
    <dbReference type="EnsemblBacteria" id="AFU59788">
        <property type="protein sequence ID" value="AFU59788"/>
        <property type="gene ID" value="Ngar_c28690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28690"/>
    <dbReference type="HOGENOM" id="CLU_640330_0_0_2"/>
    <dbReference type="OMA" id="CREINDE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2869-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="213"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="428" mass="48311" checksum="2B15549AE0DF8AF3" modified="2012-11-28" version="1">MKRSNFLVLFFIAYYIVVQPCNRNLSLESSNDKIARVITGIEVIQDPHDIQRLYTSLVQSAREEILLLLPTTSAFLREQKIGIVQSLQNAATRGVSVKVLTPTNEKIPPTMEAMFHNKDGNIEVRTIRHKSAIRGSHEARTKILVIDRKEYLVVELKDDSKETFVDAVRLAIYSTTQSTANSYITLFESLWEQSELYEQLEAHDKMQREFINIAAHELRTPIQPIIGMIDLLQAGFEKGSKESKITKEQLELIARNAIRLERLATSILEVARIESNSFSLNKERFDINEKIRNVIRDIKGLSSFGKKLKIRFEAGEPLFVEADKTRIFEVVSNLIGNAIKFTDEGTVTVKAEKQGGDVQVQVRDTGSGIDPEIMPKLFTKFATKSKQGTGLGLYISKKIIEAHGGRIWAQNNEDGRGATFSFTLPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK5</accession>
    <name>K0IKK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20710"/>
    <dbReference type="EnsemblBacteria" id="AFU59002">
        <property type="protein sequence ID" value="AFU59002"/>
        <property type="gene ID" value="Ngar_c20710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2049"/>
    <dbReference type="HOGENOM" id="CLU_014140_0_0_2"/>
    <dbReference type="OMA" id="RTPMIEI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2069-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="191"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="706" mass="75751" checksum="236B87B4EF54983F" modified="2012-11-28" version="1">MRRIRVGIDVGGTFTKAVAIDMVQGKIIGKVTVPTTHSSSEGVSTGIVQALKSLMEKHSIQNSEIELISHSTTQAVNALLEGDTAKVGIIGMGVGLEKSNVIKRTNVKDVELAPNKYLHTCYRFLDTSKYLDDKEVEQAIGELKEEGAEVIVVSEAYGVDDPSNEKFVMEKSDIPATAGHELTGIYGLEIRTLTAAINAGILPKATSTARFVESAVRNEKIAAPVLIMKGDGGVTDMGTFQSKPIITVLSGPAASVAGALLHLRVIDGVFIEVGGTSTNVCVIKDGRPEVRYVTIMQHPTCIRSLDVRVAGVAGGSLVRWSGRKITDVGPRSAHIAGLPYSCFAAPEELEGGQIITFKPKDGDPIDYVAIESAGGKRFAITNTCAANALGLVPEGDYARANQASAKMALSILANRLGTTMEQAATMVLDISAKKVLEIVEPMIKEYKLKKERIVFIGGGGGASVLVPHIARKLQLQWKIAEHAEVISSIGVAAAMIHEEAEKTINNPKPEDISTLAEQVKKAALDRGALPESITIQSEYVSERSLLRVTAMGNVSLDIGTANAQEINEEEAHVLACELFGINEGVQRIFDMKNYHIFACELSKKKLFLKSKKQPVLVLDKYGRVRLSVDNAAIFNGSPEQVAEEIEKLLKQHSASGNDLAPQVHILDGVKLMDFSSLTAPEHVSKAVRDELKKSATRDVAAIVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ8</accession>
    <name>K0IKQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59107">
        <property type="protein sequence ID" value="AFU59107"/>
        <property type="gene ID" value="Ngar_c21770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21770"/>
    <dbReference type="HOGENOM" id="CLU_3003265_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2175-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6268" checksum="48352DE7F933039C" modified="2012-11-28" version="1">MPDQDVVLTTTHDPDAVRAHLQSDLFDSSAAPHILVKPFRFSQLLALIRPSESRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL43</accession>
    <name>K0IL43_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60143">
        <property type="protein sequence ID" value="AFU60143"/>
        <property type="gene ID" value="Ngar_c32270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32270"/>
    <dbReference type="HOGENOM" id="CLU_105708_0_0_2"/>
    <dbReference type="OMA" id="YVSPANI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3227-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="18314" checksum="E2DC8E84C231169E" modified="2012-11-28" version="1">MMAGVLALIAFGVGMALYGYQVAIYPVDLAGGYLSRAESAQTPEDIAYFVRLARNELPEFGNPVWSFPTAKTDFGLIHRNLDAILARANSISSLEPYSTEYNTGMYDIHASIEGIQKQLVDATPYLYVSFTNIMLSAVWIAVILALFAIMRRGRARFRQEYENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL87</accession>
    <name>K0IL87_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33180"/>
    <dbReference type="EnsemblBacteria" id="AFU60233">
        <property type="protein sequence ID" value="AFU60233"/>
        <property type="gene ID" value="Ngar_c33180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33180"/>
    <dbReference type="HOGENOM" id="CLU_3094238_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3318-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5742" checksum="BCCC8B8FC4E2492E" modified="2012-11-28" version="1">MDKDEALKIIDTESQRFIQLANDILDVTRIEGGALTYQMKKSKLLTQSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB3</accession>
    <name>K0ILB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59407">
        <property type="protein sequence ID" value="AFU59407"/>
        <property type="gene ID" value="Ngar_c24850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24850"/>
    <dbReference type="HOGENOM" id="CLU_2191111_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2483-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12329" checksum="BA542258DDB49FF4" modified="2012-11-28" version="1">MVGRDSNNMGGNGQVILRQSIDAAIESLGGPIHKTITWYLNSRGVLSNSKKIDINFFYSNLRDLLGPGADLIMEETWQQLQKRCGGKAGQQNPPAKCSPLERIQKMIEIGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE9</accession>
    <name>K0ILE9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="4">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c34530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34530"/>
    <dbReference type="EnsemblBacteria" id="AFU60368">
        <property type="protein sequence ID" value="AFU60368"/>
        <property type="gene ID" value="Ngar_c34530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34530"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3451"/>
    <dbReference type="HOGENOM" id="CLU_1006919_0_0_2"/>
    <dbReference type="OMA" id="MTSEHYW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3454-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06195">
        <property type="entry name" value="FNR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033892">
        <property type="entry name" value="FNR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="30633" checksum="AC561DF96A42020F" modified="2012-11-28" version="1">MSSGQAPPNIGMITYRENLTPDLAIIRMQPADGSAVPDFKAGQFVALGLKLDGDDKITYRAYSLSSPPEEKRHFEFYVKWATEPVMGKFTSALFKMREGDPLYWRKPAGAFTIEDKKADGTPDTRRIVLVASGTGLAPFISYVLHLKSSRSKREVVLLHGAKYAQELGYRDMLEKMAASDPNFKYMPTVSRSDHPLSQGWRGNTGRVEKLLVSNGGESQLEKLVGEKVTPANSFFYICGYQGTIDSVVALLSPQGFVTNRNKRKDGSFDIKIETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG5</accession>
    <name>K0ILG5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c01140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01140"/>
    <dbReference type="EnsemblBacteria" id="AFU57064">
        <property type="protein sequence ID" value="AFU57064"/>
        <property type="gene ID" value="Ngar_c01140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.118"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-114-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="16138" checksum="AA76238CE3FA722C" modified="2012-11-28" version="1">MSELALDASISVPKLSKKINVNSSVVYSRIKRLVKRGLIKKFTIVINDEALGFNVKALTGINMDSKLRDNVLNELFKIPEVREVAEVTGRFDVLVTMNARSLDEMHQLISEKIGRIEGVQKTETFIEMRKTSRELAYPTSIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ0</accession>
    <name>K0ILJ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps7p</name>
        <name evidence="5" type="synonym">rps7</name>
        <name evidence="7" type="ordered locus">Ngar_c01600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01600"/>
    <dbReference type="EnsemblBacteria" id="AFU57109">
        <property type="protein sequence ID" value="AFU57109"/>
        <property type="gene ID" value="Ngar_c01600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.159"/>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_2"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="6">
        <location>
            <begin position="46"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="22529" checksum="1C0D4DE6CC561B35" modified="2012-11-28" version="1">MSGKEQVHIQLFHKWDTSNIAINDPGLKNVISLKPAVIPVTFGRHEHQRLKKAEVNIVERLANKLMHFGKKYAKNTGRMGGKKARMLNIVKTAFEIIHLETGKNPVELLVRAIENSSPNEDTTRIVYGGVVYHVSVDVAPLRRVDLALRFIAEGVRESTYSSPQTIEEALAKEIILASNNDMASHAVKKKNEQERIAMASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ3</accession>
    <name>K0ILJ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60458">
        <property type="protein sequence ID" value="AFU60458"/>
        <property type="gene ID" value="Ngar_c35450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35450"/>
    <dbReference type="HOGENOM" id="CLU_3039188_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3546-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6137" checksum="F2459E7387083620" modified="2012-11-28" version="1">MAKNLILSSLEYDRCPKGLTTNQGIPREINSRPNDIETRLLFGNSMKIKCVRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK7</accession>
    <name>K0ILK7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01900"/>
    <dbReference type="EnsemblBacteria" id="AFU57139">
        <property type="protein sequence ID" value="AFU57139"/>
        <property type="gene ID" value="Ngar_c01900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01900"/>
    <dbReference type="HOGENOM" id="CLU_1096738_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-190-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="253" mass="28578" checksum="5550EA159EB77615" modified="2012-11-28" version="1">MKSFRYDDGLDFVYRHTDHLISLAEVLLLDTYHADLLKKGDTVVDLGAGIGDFSLLASRRVGPNGKVIALEPNAEDYETLKINIEKNGCTNVIVLNMGVAGEPGQKEISFWDRRYSFAADTLENILAHLRIEKKINFIKMDIEGFETGVIRNSIGTIEQADVISIEMHGTKEEVDRMLQPRRFAFMPSDRWRACKNFVSSMAAHPRAALEILLLTAKTYPRIVRMRVNQTRRNDRLITGVYIKPAGRAAVVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP8</accession>
    <name>K0ILP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative quinoprotein glucose dehydrogenase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02610"/>
    <dbReference type="EnsemblBacteria" id="AFU57209">
        <property type="protein sequence ID" value="AFU57209"/>
        <property type="gene ID" value="Ngar_c02610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.256"/>
    <dbReference type="HOGENOM" id="CLU_2519868_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-261-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9555" checksum="735931D75FBC35F1" modified="2012-11-28" version="1">MIFGPDGKLYYTIGDQGKNQFSRYCETIRAQELPTAEQIEAEDWRAYEGKVLRMNPDSSIPEDNPEINGVRSHIFTSDTATIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX4</accession>
    <name>K0ILX4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59762">
        <property type="protein sequence ID" value="AFU59762"/>
        <property type="gene ID" value="Ngar_c28420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28420"/>
    <dbReference type="HOGENOM" id="CLU_2204195_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2842-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="12356" checksum="B69392CCD1568F6F" modified="2012-11-28" version="1">MSKMALSSITKQFQITVNVGYECTTFVVYFSEMAAKKEAIRKVQLLDEIVRIDENFYSMVFSVLYKTKQDLEKKLALIKELLAIPKEPLKLYDLSLPDPKLKLSETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY5</accession>
    <name>K0ILY5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative methionine synthase</fullName>
            <ecNumber evidence="11">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metH2</name>
        <name evidence="11" type="ordered locus">Ngar_c04950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04950"/>
    <dbReference type="EnsemblBacteria" id="AFU57439">
        <property type="protein sequence ID" value="AFU57439"/>
        <property type="gene ID" value="Ngar_c04950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.474"/>
    <dbReference type="HOGENOM" id="CLU_004914_4_1_2"/>
    <dbReference type="OMA" id="MAVWVER"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4 5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="10">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="9">
        <location>
            <begin position="416"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="8">
        <location>
            <begin position="562"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="6">
        <location>
            <begin position="426"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="826"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="829" mass="92051" checksum="095702CF315B0A7F" modified="2012-11-28" version="1">MDLRQEPPPLIIGERLNTQGSKKAKELVLNNDFDGLVDLARAQVEDGAHCLDVCVATTERSDELEFMTKLVKRLSLEIDAPLVIDSTDPKVVEAAVRQIPGRPVINSINLEGDGSRFHALAPLMAKYGLPAIAMCIGPKGMAKTPQEKLEIAQLLYDTGKQQYGLQAWQFIFDVLTFTLATGEAEFADSAKNTLEGIRLVKQRFPESFTTLGLSNVSFGLPANARKVVNSVFLYHALKAGLDTVIINARDIIPYPEIDGQQKKLAEDLIFNKHQNALAELIAHFEGAAKATAAGPTKRIEVDPSWPADKRSYFRIVNRLKEGIEDDVVQAIADRVKGNKVIQQGDGRLALAAPKEAAHEAAVETLNEVLLPAMKEVGDKFGAGELILPFVLKSAECMKAAVAELEKYLIKQEGVSKGKLVLCTVYGDVHDIGKNLVKTIFVNNGYTVYDLGKQVPLQKILEKINEVNADAVGLSALLVSTSKQMQYFVEHARQNNMKVPVLCGGAAINSSYINRIAKEGGIYGPGVFYCKTAFDGLKVMNKLMSPERKQFVSEWQQKLEKWDERQAATVVDQSQLPYSGIKPVAPPVPPHVNRPVRIEPLQVKLEEVWKYLNKKSLFVLQWGMRGKGASDQDPEKLFEQWKERVVKDKLFEPRAVYGYYKCHNLTPGQGGVGKLAVDLADGKQQVVFEFPRSSKDKHLCLADYFGKDDIVAFQSVTVGNRVTEIIDRWNKQDKYTDAYYLHGLAVETAEAMAEWVNAKIRDELKIGEKRGLRYSWGYPSCPDISQHHLVWQILDPAKSGMTLTESGQIVPDQSTAAIVVHHPEAEYFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY7</accession>
    <name>K0ILY7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57444">
        <property type="protein sequence ID" value="AFU57444"/>
        <property type="gene ID" value="Ngar_c05000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05000"/>
    <dbReference type="HOGENOM" id="CLU_2021574_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-498-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13560" checksum="870ACA54554C9A12" modified="2012-11-28" version="1">MASWRSSSLAVFILGMAILGVLLYLPAMAQQKFVDNDDIEYTQFTCAPANAELKFGYNCADIWEAEKIARADDKIAEIVNGQEYHLIGYAFVDDAGPHGVSPTSQNPTQYPFLNFFVEGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM02</accession>
    <name>K0IM02_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative archaeal serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c05360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S16.A12"/>
    <dbReference type="EnsemblBacteria" id="AFU57479">
        <property type="protein sequence ID" value="AFU57479"/>
        <property type="gene ID" value="Ngar_c05360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05360"/>
    <dbReference type="HOGENOM" id="CLU_867689_0_0_2"/>
    <dbReference type="OMA" id="QACPAGM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-534-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="320" mass="34033" checksum="1FC436928013D453" modified="2012-11-28" version="1">MSAKITVILGILILASAAGNVYLYQKTTSLENTISQLQATNEELKDDLANAQNNNNQSSSSIGSSSTITGNLPSFSGSLQQGNNKLANMTSQSITAVAVKAVPVSDGFFQTVRYQGTVMDITVDIRDGRGLVLVNTEIPTGVDFQTSARTAVKVAQSMTGADLSRKDVIFSIKAKGENSTASDLQAVDGPSAGAAMTVLLAAELGNNAELKQDVLMTGTINPDGTVGLVGGVPEKAVAAGQYGAKIFLVPSGQAVYNEQTCEKRQEGPFIYQTCRTEQKSLSEYTEKNYGMKVIEVKNIKDALAYFQSWINLPNTIKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM78</accession>
    <name>K0IM78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57629">
        <property type="protein sequence ID" value="AFU57629"/>
        <property type="gene ID" value="Ngar_c06860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06860"/>
    <dbReference type="HOGENOM" id="CLU_1763928_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-684-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="147" mass="17323" checksum="6FEB0A946195EB0B" modified="2012-11-28" version="1">MASKYVWVGIAVGLFLLGVAVGYGIFVSAQPQMPMNQQQQMLRQMMNQWNQQMMNDQTGRQQMMMSMMQNQQFMQEMMNDTQFQSRMIENMRENHDFMQSMFMQMMDDPEIRGQMIGHMIENQQFMEQLRQNVGNNPSSSGDMGMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD3</accession>
    <name>K0IMD3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57809">
        <property type="protein sequence ID" value="AFU57809"/>
        <property type="gene ID" value="Ngar_c08670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08670"/>
    <dbReference type="HOGENOM" id="CLU_2821037_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-865-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7546" checksum="01894C12B4008679" modified="2012-11-28" version="1">MLCDSTAPAAADTRLFLLTFQFVLLNLRVLASDIEHRLTSSPDFSAVPLKETFYYKHWIKLTEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF2</accession>
    <name>K0IMF2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60217">
        <property type="protein sequence ID" value="AFU60217"/>
        <property type="gene ID" value="Ngar_c33020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33020"/>
    <dbReference type="HOGENOM" id="CLU_3003271_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3302-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6588" checksum="15545A3496BEA5EE" modified="2012-11-28" version="1">MTLQCPVCGSELEELRPPDDETIARMGIVVETRTYYCKECNELYSKGWLKDRIFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF3</accession>
    <name>K0IMF3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60222">
        <property type="protein sequence ID" value="AFU60222"/>
        <property type="gene ID" value="Ngar_c33070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33070"/>
    <dbReference type="HOGENOM" id="CLU_2021581_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3307-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="14505" checksum="DC7F0DE5B6EA974C" modified="2012-11-28" version="1">MYKPPPTISISLKDVRNDNRRPWQSPNAIGVNFAVQAAYYQNRPNKNLPLFYVEDSMKIFRLVGIPTIRVPFYWESYERSRQEFYKDLFHILEQASINDLQVVLDNHQWETGSWLGWGPWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF9</accession>
    <name>K0IMF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57869">
        <property type="protein sequence ID" value="AFU57869"/>
        <property type="gene ID" value="Ngar_c09270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09270"/>
    <dbReference type="HOGENOM" id="CLU_3148093_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-925-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="48" mass="5672" checksum="65BE7AC59071349F" modified="2012-11-28" version="1">MVVQMDILGPFYLRNSSTKNYIIVSCIDDCTRKVVSKWTERKRGYRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN21</accession>
    <name>K0IN21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c16810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58614">
        <property type="protein sequence ID" value="AFU58614"/>
        <property type="gene ID" value="Ngar_c16810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16810"/>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="OMA" id="YLDTNIY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1679-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="210"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="397" mass="44543" checksum="26D4E3342C950120" modified="2012-11-28" version="1">MKAAVIHHTLNTLGGETTVAIDAIESLHELGYEVDLITVQPPDLERVAKAYGKDLQIKHMISLLPFKANYFGMYQKLMTVLLSSRIHGADIVLNTHGDLLPYHIEGSRQISYVHFPAFLLTSSEEFRNWKYENSLFWRAYFKPYQSISSFLAKRAARNNNNLGLVLVNSAFSKNAIKKVFPDIDVRVLYPPVDTDRFSNACDSDIADGSQVLTVSRFSPEKQIENAIKVALLLPDTRFEIAGALMRANTSYFKSLQNMIERHGLGNRVRLKPNATNEELLDSMSKSSVYLHTMAGEHFGMSIVEAMSAGLVPVVPSYGGCSEIVPAEYQYGTVREAADRIARIIDSGDHSKTARRRMRNMAMRFSSKEFKKEIKKYIEQVKSVPIEAGKRSQPAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN23</accession>
    <name>K0IN23_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">psmB2</name>
        <name evidence="9" type="synonym">psmB</name>
        <name evidence="10" type="ordered locus">Ngar_c16910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16910"/>
    <dbReference type="EnsemblBacteria" id="AFU58624">
        <property type="protein sequence ID" value="AFU58624"/>
        <property type="gene ID" value="Ngar_c16910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1668"/>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="RVSYGFY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005066434" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023481001" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="21799" checksum="8B3909A9FB3D8DCA" modified="2012-11-28" version="1">MAFEFMPGATVVGISYNNGVILAAEKRVSFGNFVVNKNIKKTFSVTDHVGAACAGMVADMQVLVRQVEALAKIRKLETRRDVAPNSIAKLMSVIMFERRYFPLLTQVIVGGINTKPEIYTLDPLGSVLPDDYAAVGTGAEMALGIMDAEFKPNMTEEKAKELAVRAIRSAIQRDAASGDGIDVLVVSRTGHREETIPIRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN48</accession>
    <name>K0IN48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tetrahydromethanopterin S-methyltransferase, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18160"/>
    <dbReference type="EnsemblBacteria" id="AFU58749">
        <property type="protein sequence ID" value="AFU58749"/>
        <property type="gene ID" value="Ngar_c18160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18160"/>
    <dbReference type="HOGENOM" id="CLU_1674043_0_0_2"/>
    <dbReference type="OMA" id="AIWGSSK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1814-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030688">
        <property type="entry name" value="MeTrfase_MtrA/MtxA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04208">
        <property type="entry name" value="MtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17064" checksum="1CD7185F2938720F" modified="2012-11-28" version="1">MGIRKKLDDVAGKVCEAVLPIKHEYHLGMGKELAICTLSSMDLLEKLSKSDPVMNKIAIAGRLLSENRGIDAMIKFALDHPELRRIIVCGKEVKGHRAGQALLALARNGIDRNGRIVGALGPYPILESPAGDVDAFRQQVEILDMIGTTDIEKLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN73</accession>
    <name>K0IN73_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58874">
        <property type="protein sequence ID" value="AFU58874"/>
        <property type="gene ID" value="Ngar_c19420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19420"/>
    <dbReference type="HOGENOM" id="CLU_616264_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1940-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="444" mass="51132" checksum="99AF28B9E668A702" modified="2012-11-28" version="1">MISINTSDLEREYIGILERDLYDVGQVEKDPLGNAIYLFFISRNKIKTSITENLIDWANSYVHTVLGQHKLSRFQDKDVTSAILCYYSLKQLDCLKVVVDVKLIDSLLDRYCSRDRYFDEFTHSCIILFSLYDIKEGITSYQKVLASILKAVNSPEVMNDPKNLVFSAILLDATQDVQLLKNLLHITLGHINEKSIPYNDSIYYAWLVWQYKELFEKNALTRVRGYVREVIEGLRWSLIEKEELEEIESIYGREEGPMVLSKIQISVSLDLVSSYNKEPGILNKLDHTVILADLRVDAVKQKINETKKTVSLLGDASVLLQSAEKKILDAETKLAEDPDACLDLLGEAMESLCRTYLTQRKIPFKALSGLELHDSVIKDWKEKSSLPWTDLKYQTGLRHILRVWALKKHEAYSTNLLEEAYFILLGWRGCFEIIRMIKETNPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN90</accession>
    <name>K0IN90_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58959">
        <property type="protein sequence ID" value="AFU58959"/>
        <property type="gene ID" value="Ngar_c20270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20270"/>
    <dbReference type="HOGENOM" id="CLU_2712969_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2025-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8035" checksum="50D434B2DF94384C" modified="2012-11-28" version="1">MHKIPSPYHTVSQSYLVVIVIGNATNIDAALLKRLSRMYEAGISIKDISDQLRMDQMTVKKLLKLLGYAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN93</accession>
    <name>K0IN93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58974">
        <property type="protein sequence ID" value="AFU58974"/>
        <property type="gene ID" value="Ngar_c20420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20420"/>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OMA" id="DYMRASG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2040-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="22976" checksum="D60C6AF64918B1BA" modified="2012-11-28" version="1">MPDDPSISENVPQSKKTRSVTFRLDSSVIDELQAEADNREISLNVLVNQILKRYSEWERFENKIGMMPVPKVILSSLIDKAISVAKSSGIKDVDRYRDEIIKQAAQIAFGLMKDSVLFMKRQYNLWVVLAVLEEYMKVSGIKADHKLEGSRKHVFIIQHELGENWSLFTKELLNLIFQNLANVRADINTTPNTTVAEVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA3</accession>
    <name>K0INA3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative archease protein family (DUF101/UPF0211)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c20930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20930"/>
    <dbReference type="EnsemblBacteria" id="AFU59024">
        <property type="protein sequence ID" value="AFU59024"/>
        <property type="gene ID" value="Ngar_c20930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20930"/>
    <dbReference type="HOGENOM" id="CLU_111362_3_0_2"/>
    <dbReference type="OMA" id="WLSELLY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2091-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="16352" checksum="6C2BBEA5FC9E769C" modified="2012-11-28" version="1">MAGGYCFLDHMTDAVIEAYGETLEEAFENAAKGLNDTMVDLKTVMPNEDLKITAQGHDLYSLLFDWLDKVLLLLVADGIVMSEFSVKIRQHDDNGDGYSLTGIAKGEKLNLDRHHYKVEIKAVTYHEMEIRQEKGKATVKFLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND2</accession>
    <name>K0IND2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22390"/>
    <dbReference type="EnsemblBacteria" id="AFU59169">
        <property type="protein sequence ID" value="AFU59169"/>
        <property type="gene ID" value="Ngar_c22390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22390"/>
    <dbReference type="HOGENOM" id="CLU_2406456_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2237-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10531" checksum="A6ABECD75D1E425E" modified="2012-11-28" version="1">MKIIHATPGMGAPMSEEELKNFLPTSKQNCRLATVEKDGDPNVHPVWYPYEPLHNKIYINNDSRKAMNIRRRDAVYFCIDDEAMPVKGVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN6</accession>
    <name>K0INN6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59689">
        <property type="protein sequence ID" value="AFU59689"/>
        <property type="gene ID" value="Ngar_c27680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27680"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2768-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="55"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19747" checksum="4D463C7AF5B05396" modified="2012-11-28" version="1">MQVTKSNNRRSQALLLEFNPVALKLSVPNILSKIALSLPSATGSAPKDDRRSKPRILYIDDEVNITKVIKYGLEQYGFAVDVFNHPKAALSSFQPGVYDLLLIDIRLPEINGLDLCNKLLRIDSNVKICFITAYDLKKEEVRNRVPDLQTECIIKKPVSFDNLVSKINGQLHRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP5</accession>
    <name>K0INP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59734">
        <property type="protein sequence ID" value="AFU59734"/>
        <property type="gene ID" value="Ngar_c28140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28140"/>
    <dbReference type="HOGENOM" id="CLU_2177963_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2814-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="11541" checksum="52CFF6C4C85D9B0A" modified="2012-11-28" version="1">MLTTTPSKVVWIVAVGYLAFFFALASGMINAIIEGRDFGGFILPTRSVQTIGETVVITLILFIGMAGTLMLYHSGRSVNPQVQKALLIAGFGVLGIALLLGFILVGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW6</accession>
    <name>K0INW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60089">
        <property type="protein sequence ID" value="AFU60089"/>
        <property type="gene ID" value="Ngar_c31730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31730"/>
    <dbReference type="HOGENOM" id="CLU_2152692_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3173-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="11962" checksum="45216957486A4E72" modified="2012-11-28" version="1">MLNSIISRQLASSGCGKLLSGDGITTPDLTIKGMPGIIASFAKLVPILKEKPGDLAQWNTHARSLLEETSEAYVKAKANAKLQVASHKEAFEFFGVPEDRIDAALRAFYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP02</accession>
    <name>K0IP02_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <ecNumber evidence="1">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemL4</name>
        <name evidence="1" type="ordered locus">Ngar_c33540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.3.8" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33540"/>
    <dbReference type="EnsemblBacteria" id="AFU60269">
        <property type="protein sequence ID" value="AFU60269"/>
        <property type="gene ID" value="Ngar_c33540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33540"/>
    <dbReference type="HOGENOM" id="CLU_1754763_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16970" checksum="9181D70664B02011" modified="2012-11-28" version="1">MKENATKKILRNGTYARNPVSIAAADATVDEIIMKKGYVHRNIEKFGTALMNGIRDILYYRKVDGIVQGYPSMFHVLFTKQDGVHNYREYLKCDNKFSSKLQERVLERGVMLSELFFTCTAHNGEDLQQTLEAFDASLLQQQVSSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP28</accession>
    <name>K0IP28_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tellurium ion resistance family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">terC2</name>
        <name evidence="6" type="ordered locus">Ngar_c34850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60399">
        <property type="protein sequence ID" value="AFU60399"/>
        <property type="gene ID" value="Ngar_c34850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34850"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3487"/>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="354" mass="39382" checksum="25CEEF76F96CFB41" modified="2012-11-28" version="1">MEFGIISEGYILWIVFGLFVGIAMAIDLGAIGALRKMLRAKASSQPASDNNQSGKDKKKSTFKQALAWTIVWISLAIIFAVIIYSTSGYGSFLEFVTGYTLEKSLSVDNMFVFIIIFSSLGIPHQFQHKVLSVGIISAIAMRIPLIIAGAALLESFHWMMYVFGAFLFVTAIRMALQRKEREKIDIEKNIAVRLLRRFVPLTPQLHENKFLIRLANGALYATPMLVALVIVEMTDLVFAIDSIPAVLAITTDPFIVITSNIFAILGLRSLYFLLAGMMEKFYYLKPALVALLIFIGAKMLMSDLYKIPIEVSLGVIFAILGIALGLSAIKTKTENERHATTLRKDSDHRESSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP40</accession>
    <name>K0IP40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60459">
        <property type="protein sequence ID" value="AFU60459"/>
        <property type="gene ID" value="Ngar_c35460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35460"/>
    <dbReference type="HOGENOM" id="CLU_2784245_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3547-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7697" checksum="F04DA48E7251418B" modified="2012-11-28" version="1">MPMAFELAKDSETKNWQFAKIAIIVLAGIAFIFLGLSVITLAAFYAPIIIAVVILIVLYERWKEKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8C8</accession>
    <name>K0I8C8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative asparagine synthase</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asnB1</name>
        <name evidence="2" type="ordered locus">Ngar_c05880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05880"/>
    <dbReference type="EnsemblBacteria" id="AFU57531">
        <property type="protein sequence ID" value="AFU57531"/>
        <property type="gene ID" value="Ngar_c05880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.563"/>
    <dbReference type="HOGENOM" id="CLU_688115_0_0_2"/>
    <dbReference type="OMA" id="WINREWI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="445" mass="52055" checksum="3FCFEEFA15F4A160" modified="2012-11-28" version="1">MTFRIISPQLGNFSHSIIQFKLYYSIIRKIVMLKVLMKSDLDSISRVLTLRYDPLEKPVRKPLISSDFTPYSSYGEDVEASILDLIKKELLNKYDELKLKNVSLALSAGVDSRLTLAMIRTVLPDVKIDCISVGFGDKEDEVSQAKEISRVYDCNFHNIILDEVLSDLPKLIAIVKKPKWNLYQFYPLEHGKKYSNVFYTGDGGDELFGGYTFRYHKFLSLLPRDKGWKTKVKLYLSCHERDWVPDQNKMFGSAVKFSWEKIYELFRPYFSNDLEPLNQIFFADFNGKLLYDWLPANFAFADFLKIRIESIFLTSTMIDFATHIPPDKKYDLRTRIGKLPLRSILIKHKGNEKMMEPVKKGFSIDLISLWNRHAKEIVSAYVNAESEVVRNKIIDKDWITISTRKLEEKNSDLRHRYINKMLSILALEIWYRLFISKSLNSRQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I906</accession>
    <name>K0I906_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aconitase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08140"/>
    <dbReference type="EnsemblBacteria" id="AFU57756">
        <property type="protein sequence ID" value="AFU57756"/>
        <property type="gene ID" value="Ngar_c08140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08140"/>
    <dbReference type="HOGENOM" id="CLU_018825_1_0_2"/>
    <dbReference type="OMA" id="CTCTPYL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-812-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="382" mass="41139" checksum="038589642438D1E3" modified="2012-11-28" version="1">MELSKDEEEALAGKHSEALASAYRILVAIGEATGAKKLVPVKWAHVSGVNYNTIGDAGVQFLDKFSRTAKVVVRTTVNPMGYDRNKPEGIPEKFQEKQASIVKSYERMGVTPSFTCTPYEVFNIPDKGTAVSFAESNAAVYSNSLLGLMTNKESALSALASSVTGKAPLSDLRLEEARKPKVGIKVDFKFESELDYGLLGYFAGKTVKDSSVAFSGIPKPSTIEAKALSAAIGTSGSCGMFTLGEAKERVSFGKQEAKAVMEELNTAEDGDIITLGSPQLGMNELDLLARLTEGKKFSKRCMIFCSRAIHNQAAKVGLAGKLERAGAEFMCDSCTCLTPYVTKEKYDSVVSNSVKGAYYLSNSNKVKVALKDIKTIVKEYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9T7</accession>
    <name>K0I9T7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative digeranylgeranylglycerophospholipid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11500"/>
    <dbReference type="EnsemblBacteria" id="AFU58091">
        <property type="protein sequence ID" value="AFU58091"/>
        <property type="gene ID" value="Ngar_c11500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11500"/>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OMA" id="GMCRREV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1148-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="401" mass="44224" checksum="B2E5AADE35D01AC4" modified="2012-11-28" version="1">MEEERYDIAVVGGGPAGLSAAYSAARAGAKVVLFEKDEAIAHSVRTSGVTWISEMERLGIPARYYNPVQNYRFVSPLNDVMISGSTPKSCVLDVRGTYQHLAFMAAEAGAKIMVKSNIINVLKQDNNKIAGVKASTPKGDLTVRSTLVIDASGFSASVARRAGASGEWKRYGVGAEYECYCDDIDSATWVLMVGRRYSDAGYAWIFPLSRNRVRIGVGIGRPESSAEPLEKLHDILEKRHRPLDTFGKIQPVELHYGFIPNEGVRQNSIADGLVMVGDSAGQSNPLVLEGIRYAIEFGRLAGEVGAKSLPRGASRESLMDYEKAWKAKVESKIQSALRVQTRWLGLTDEEWDKEIEILRDMTVDEFLDFIKADFTAGKMMKLALHHPKLAARQLFNMILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA91</accession>
    <name>K0IA91_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">napA</name>
        <name evidence="7" type="ordered locus">Ngar_c13030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58241">
        <property type="protein sequence ID" value="AFU58241"/>
        <property type="gene ID" value="Ngar_c13030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13030"/>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="ATHHVAR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="11"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="423" mass="45059" checksum="5FA5B528A67AB3DA" modified="2012-11-28" version="1">MATEQLFVSIVIILVAARILGELFQRIKQPPLVGELLAGVVIGPSLLGLVLPSTDLQVLSDLAVFFLMFLAGLEMDPKEIRRAGRSAIVISLVAFFIPLLAGTGVASLFGLTIVQSLFMGLLLSITAVPVSAIVLMQFGILNSRLGNTVMTAAVINDILSLIVLSIILQIHTAEGTGAQVDFENVGWSGAKIAAFLGGIFLFDILFRKTSSWLPSRVEPFFKKYLQTKEAAFGILLITTIAISLIAQDIGLHFVIGTFFSGLVVYKEMIGRQNFNRVYGIISAITFGFFAPIFFALIGIEFNVQSLINAVPLFFALLGVAVATKIAAGYAGAKLVGFNHEISLAIGFLMNGRGMVELVIASIGFAAGVIDLTLFSIAVAIGLVTSILAPVTSRPLVSKAKSRGSEAVEVKEPPNDQQHSAAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAX5</accession>
    <name>K0IAX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58486">
        <property type="protein sequence ID" value="AFU58486"/>
        <property type="gene ID" value="Ngar_c15520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15520"/>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="OMA" id="DDSECSH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1550-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15095" checksum="201951F6D26A5C96" modified="2012-11-28" version="1">MFSKVLVPVDGSDNSFRALDAAISLAKTTGASLTAMHVIENPPTVYVESQKLLNELLAKYRSESAKVLDKCKQKADEAGVKLETVIAEGDPASNIAGYAHREGFDLIIIGSRGLGRFKEMVLGSVSNKVLHHAKCGVLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAX7</accession>
    <name>K0IAX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c15570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15570"/>
    <dbReference type="EnsemblBacteria" id="AFU58491">
        <property type="protein sequence ID" value="AFU58491"/>
        <property type="gene ID" value="Ngar_c15570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15570"/>
    <dbReference type="HOGENOM" id="CLU_042134_1_0_2"/>
    <dbReference type="OMA" id="KRFWRAW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1555-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="101"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="413" mass="44601" checksum="6CA530F563563D62" modified="2012-11-28" version="1">MEQQKSRVRAEVKLPLILIHTPFGLKFFDRVAKWRAAKVYADFNTYLMPAITGLAIFLIIGSLMIMFSNSTARGAVADVGPQANLLIPGLNPFLPITYGWAALIITIIIHEAGHGIVARVYNIRVDSTGLVLFLGLPIGAFVNIERDELNKATLKQKSAVLTAGPLNNMILAGASLFALFLVVSTLTPLPPDPDAPQFGVMVANVRGGSLSESIGMQPQSVIQYVDGQRVEAIEDLGPLLRDNLGRTIDITWVDKSYNTITRQVTLPAAVEPGRGILGVDVTPLSPDAQPVLDRYKSAFGSNPLALLLPPTMQPTVVPYSDVMAPRYTSSVLGDSFVFGPVANLLFWLWFINFNVGIFNALPIGPLDGGQLYGALIEKRAKSKVLAKNANMLLTLVMVAIVAAAILVPYVPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBH0</accession>
    <name>K0IBH0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58626">
        <property type="protein sequence ID" value="AFU58626"/>
        <property type="gene ID" value="Ngar_c16930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16930"/>
    <dbReference type="HOGENOM" id="CLU_1745602_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1691-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="15922" checksum="34AAE14C1C4B6971" modified="2012-11-28" version="1">MTILDVQMSSGEKITAESGATVYIKGDIEIKTRTCEGGLLKKLKVTALGSESFIVNNYIAQGDCSIGVTGPPLGDIVRPDIKPGSDFIVQSGSYVASTQGVLLDTKWQGFTKGLFGSEFFMLKAMGQGDLFFNAYGGIMHKQLAASERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBW5</accession>
    <name>K0IBW5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18480"/>
    <dbReference type="EnsemblBacteria" id="AFU58781">
        <property type="protein sequence ID" value="AFU58781"/>
        <property type="gene ID" value="Ngar_c18480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18480"/>
    <dbReference type="HOGENOM" id="CLU_182721_0_0_2"/>
    <dbReference type="OMA" id="FMFREES"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1846-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9069" checksum="BA7C83BBD8499806" modified="2012-11-28" version="1">MSYGRRNDNFGPKPVETGKEYDVQITEISRKGDGIARIQGFVIFVKDGKVGQNAKIRISQIGPRFATAEVVNGSAPASQDTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBW6</accession>
    <name>K0IBW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c18540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58786">
        <property type="protein sequence ID" value="AFU58786"/>
        <property type="gene ID" value="Ngar_c18540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18540"/>
    <dbReference type="HOGENOM" id="CLU_1017868_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1852-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="129"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="28729" checksum="0082791501D22C70" modified="2012-11-28" version="1">MEMLATQIQLAPLVIAANSIPLAGAVMLLISFGSEKKKSITVFQSWKYLLPGSVLLATGVFAWYDSVGRVGASKEGLLAGPLETVVILLLARAALSEKLSRLQLAGVMIALAGFFATVMSSGLDALITFGDIEAMLSATAFGSGIIFITKLAKTHSAQAVTGSSLFISGLILAMILWTTQAPAISAQDWMVLLLFSLLPLTAALTYVVGLSRIGASLTSIIGSFSIILTVVFQLALLWQNVEVILPANIPLAVAGGIMGVFGIYLIHRTKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBZ8</accession>
    <name>K0IBZ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative citrate/ citryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.34</ecNumber>
            <ecNumber evidence="4">4.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">citE</name>
        <name evidence="4" type="ordered locus">Ngar_c01250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.3.34" evidence="4"/>
    <dbReference type="EC" id="4.1.3.6" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01250"/>
    <dbReference type="EnsemblBacteria" id="AFU57075">
        <property type="protein sequence ID" value="AFU57075"/>
        <property type="gene ID" value="Ngar_c01250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01250"/>
    <dbReference type="HOGENOM" id="CLU_044864_0_0_2"/>
    <dbReference type="OMA" id="AWLFCPA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008816">
        <property type="term" value="F:citryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="289" mass="31372" checksum="1A9C9A00E213A136" modified="2012-11-28" version="1">MMFRSLIFVPGNSTRFVEKAKMLQADIICFDLEDSVPANEKDAARKIIADAISRRQEYGRPVYIRTNSPESGLVALDLKAAVRKGVDGIVIPKVNDAQEVSKIKKQVAALEKERKTGGKVALMPSIETARGVVNAYQIAGADERVNALVFGVFDFLHDMRLDYDESDPAGYAYARAKVPVDARAAGVHAIDAIWQKVDDADGLVKDATVAKRLGYSGKSIIHPSQIEPVHKVFLPSKNEIEWAKKVVQALGDAMEKGSGRGAVRLEGRMIDAVHYKQAKAILDAAAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC79</accession>
    <name>K0IC79_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58966">
        <property type="protein sequence ID" value="AFU58966"/>
        <property type="gene ID" value="Ngar_c20340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20340"/>
    <dbReference type="HOGENOM" id="CLU_1811358_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2032-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="17046" checksum="BB8FDC7ADA9007C4" modified="2012-11-28" version="1">MSHKINFDEPIPDLVERLKKEHRQFELKLAELETIATVNNQSMGILEELSEPILRHAVEEEAIIMRVIMHKAREQAEESIKIAQEHNWIMEFFKHKLPQMTTTMPQQQAKQELTQFIQNLRTHFSEEEEIMFPLAIKASSLQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICW6</accession>
    <name>K0ICW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59201">
        <property type="protein sequence ID" value="AFU59201"/>
        <property type="gene ID" value="Ngar_c22710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22710"/>
    <dbReference type="HOGENOM" id="CLU_846261_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2269-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="328" mass="38348" checksum="4C8206A310B15A19" modified="2012-11-28" version="1">MPDNEAAVRKLHEKIDDYRLTVGAITAFGHVIIRYYSGTFRMGKKLQPSPANRVQAKKPVTPDVLAQGSDVKIIGEVKKGFPKDRNRWLQDLKQVEKYDDELKGWPDGDIKDHDLILFVHYPRAQALVDYTQEQIQKGTVTFNRKLAIVEYNRDSESSTFWTLKRIWGDITNSILSERLRQVITINADEIVEELSSLWFYDSEPELPYTMSVIWDKVFSEKATLEAYRKARGRKTLELSFTVDEILEKLRLYFSYKDSSFPSRDWVEHAMDAFVKFGRADKTAVGYTVYYHRVEIDLLDYFIREWIERSVDVRELIDKMAKQTDESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICZ9</accession>
    <name>K0ICZ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57540">
        <property type="protein sequence ID" value="AFU57540"/>
        <property type="gene ID" value="Ngar_c05970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05970"/>
    <dbReference type="HOGENOM" id="CLU_1140596_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-595-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="243" mass="28397" checksum="3BD2DF7AA528E5CE" modified="2012-11-28" version="1">MSAEDSTAHIYDYLYHRTHFARCMYRNFAKTINRHTKGGRILELGCGVAYLSGILSADTTLDRYCMDFAYNMLKKAKTRCSQCVQADMEYLPYSDKSFDAVFVSSALHHFPYLENVVKETQRILKPNGHLFIQEPNDHHLHFTKPLAIMHECLRKLGVRQYPDVSKLEVKPSEHHAPLPIDMVVASLQNNGFSIVNQKYLYYSSYLFSVFDNRLVHWLSRIPDKYYVNKLHDGYLFMIIGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID70</accession>
    <name>K0ID70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TrbE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06670"/>
    <dbReference type="EnsemblBacteria" id="AFU57610">
        <property type="protein sequence ID" value="AFU57610"/>
        <property type="gene ID" value="Ngar_c06670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06670"/>
    <dbReference type="HOGENOM" id="CLU_1044337_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-665-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-loop_TraG" evidence="1">
        <location>
            <begin position="158"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="29924" checksum="B26B12C6A5706FB2" modified="2012-11-28" version="1">MSRMLQRNPDAALFVFDPENEYMKLRNILEANVVEFDPHSDMGLDPLKIYPPIDASEIIASITSLPQDYHATLRTIANKADNIGALYNNSPEEMRGYLKDLVGDGTLAHVFRGKPVEFTNRMVFSMKDIESSIEKNLLSLLLFGKVWNMINDESYLPRAVQKIVVVDEAWLYLAIPAAARFLERTARLGRKRNVCFIINTQRAADVLGESDEKPGLGRSIIENSATKILLRQDELSADVVARAFGLSEREREHLVELESGNGFLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDB4</accession>
    <name>K0IDB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57655">
        <property type="protein sequence ID" value="AFU57655"/>
        <property type="gene ID" value="Ngar_c07120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07120"/>
    <dbReference type="HOGENOM" id="CLU_2165344_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-710-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12559" checksum="71614EBC6579A426" modified="2012-11-28" version="1">MKKDNKRSSTLQEAAKGLDEQHILEAIETGIEHALGAETKMLFFKTLKLVYKLERNAIPSNLERFDELLDRILGANTAEVVRQQIISELEKRRKTRRPKGGQTNSHQAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDK1</accession>
    <name>K0IDK1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57750">
        <property type="protein sequence ID" value="AFU57750"/>
        <property type="gene ID" value="Ngar_c08080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08080"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-806-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11232" checksum="33E42EB4D873494A" modified="2012-11-28" version="1">MSERKNNRGKIEIMADILSLSTAGIKKTHIMYRANLSYEQILYYLNQLLGKGLIAQDVVDGALVYRTTEKGREFLVCYSRMSELITESCPDEKVPLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDZ1</accession>
    <name>K0IDZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putiative histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c10330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10330"/>
    <dbReference type="EnsemblBacteria" id="AFU57975">
        <property type="protein sequence ID" value="AFU57975"/>
        <property type="gene ID" value="Ngar_c10330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10330"/>
    <dbReference type="HOGENOM" id="CLU_056776_3_2_2"/>
    <dbReference type="OMA" id="YNIGVNC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1031-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="15331" checksum="FDBC96E95E800A0C" modified="2012-11-28" version="1">MQDENCVFCKIAGDKIPARVVMQNDKAIALLDAFPLAAGHTLVIPKSHYAKVQDMSKEDALAVFEITWKVAGAVEAGSQVTASIIAIHNGSEAGQEIPHMHVHIVPRKKGDGAGAIHSMFKNRPKPSPQEMDALRDKIANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE57</accession>
    <name>K0IE57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase of the haloacid dehalogenase (HAD)-like hydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27200"/>
    <dbReference type="EnsemblBacteria" id="AFU59641">
        <property type="protein sequence ID" value="AFU59641"/>
        <property type="gene ID" value="Ngar_c27200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27200"/>
    <dbReference type="HOGENOM" id="CLU_1259134_0_0_2"/>
    <dbReference type="OMA" id="DICMIRR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2720-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="216" mass="23603" checksum="88E1E6263B260153" modified="2012-11-28" version="1">MPKLAGFDMDGTLIQGRLVFALADRFDLSDKVRAIQQSEGMLGHEQTKAIAALFAGLTKKDLLDAIESIPLTKNCERTVAALRERGYYKIGIISDSYTVAASAVADRLQLDFVSANELQMENGKITGKVKMPLGWEKIGCFCKISVCKRYHLEKAARQFGVPIQATLAVGDTKSDICMIRRAGVGVVFMPKDSEIAKAADKIVQESDLLKVLEFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEB7</accession>
    <name>K0IEB7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">30S ribosomal protein S5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps5p</name>
        <name evidence="7" type="ordered locus">Ngar_c01990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01990"/>
    <dbReference type="EnsemblBacteria" id="AFU57148">
        <property type="protein sequence ID" value="AFU57148"/>
        <property type="gene ID" value="Ngar_c01990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.199"/>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_2"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="22008" checksum="D27E112ECF2A8895" modified="2012-11-28" version="1">MFQPPGQQQTEWKPRTTLGSMVLAGKINSMDQIYENGMRIQEAEIVKHLLPDMKNQVVHVGIVQKQTDAGEMTRFNALVAVGNEAGWFGIGKGKASQMRVSIDKATNAAFLNVIPVKLGCGSWECKCNQLHSVPFKVRGKGGSVTIEIIPGPRGLGIVAGENIKSLLKLAGLKDAWTKSFGSTNTMSSTTKAIFNALRSTYSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEL6</accession>
    <name>K0IEL6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sufC</name>
        <name evidence="5" type="ordered locus">Ngar_c28770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28770"/>
    <dbReference type="EnsemblBacteria" id="AFU59796">
        <property type="protein sequence ID" value="AFU59796"/>
        <property type="gene ID" value="Ngar_c28770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2853"/>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_2"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="28108" checksum="8185798348A64BC9" modified="2012-11-28" version="1">MTFLEVKDLHVSIDGKEILSGLNLKVEKGEVHAIMGPNGSGKSTLANAILGHPKYNVESGDILVKGESILDLPTDQRARKGIFLGFQYPTEISGVGYSHFLRNAYNTLNKEDKTREVFLTVREFHEYVKKNLDAVGLDKSFLGRYLNEGFSGGEKKRSEVMQMLVLKPNIAILDEPDSGLDIDAVKAVAEAINKLIETGAGVIVITHYARILRYLTKLDHVHVVAKGKVIKSGGKELSEELEAKGYGWLGIEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP0</accession>
    <name>K0IEP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57248">
        <property type="protein sequence ID" value="AFU57248"/>
        <property type="gene ID" value="Ngar_c03000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03000"/>
    <dbReference type="HOGENOM" id="CLU_989072_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-300-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="281" mass="31975" checksum="145D404FAE8FED2B" modified="2012-11-28" version="1">MNLLTIGRNQENVVDEDALVFYEIISKCIGQKLDPTKDRIFVDKPDTQSRSSGSHMLYCTINGSRRVALKRCYDNSEFLRRELVIADAKRKLMFPSYNMFKIDGLKLRNTLTKNSCTLTQGWENKPLLVIDFGNPSDIINLRDLTRAKIANMQSFCHSYGSWTAFNIFFGVRDRHAMNFIFTKNTQILHSVDNEEGPLDSSGRFIGVNDIAMTMSQNIQRLIAGANRDLCIQWLREGFIDGLARIRSVDPSSISMLNANEIALLEQMLAQAPSNLQNDVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP8</accession>
    <name>K0IEP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, DHHA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12900"/>
    <dbReference type="EnsemblBacteria" id="AFU58230">
        <property type="protein sequence ID" value="AFU58230"/>
        <property type="gene ID" value="Ngar_c12900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1236"/>
    <dbReference type="HOGENOM" id="CLU_071985_0_0_2"/>
    <dbReference type="OMA" id="HDTCCSA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1288-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="326" mass="35480" checksum="537E47490DE24FC1" modified="2012-11-28" version="1">MSSVCISHKEDADGLCSATLIKVAFDVSKVILVDYASLISKLEKVAASDGKIEQLFICDLGLSKKNEQKFVELLGNIASSGAEVTYIDHHDISKEIMQALKKAGVTLIHTIEECTSMQVYAKYRKKLPEHAAFFAAMGALTDYMENKPVASTIVPRFDRQFLMLESTVLSYMISASQHDDDFLVKIVDTLAKMKYPHDIKGGFETAEKYAKKVANAVESIQESVVKLDNIAHAPSTVELSSSMVVNFVLGSSGKPAAMVYKFKDDIKSYVVSIRGSAGCKVHLGRLTNEIASELGGSGGGHDRACGAVIPKDKLEEFIKTLDSRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IES0</accession>
    <name>K0IES0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DM13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58255">
        <property type="protein sequence ID" value="AFU58255"/>
        <property type="gene ID" value="Ngar_c13170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13170"/>
    <dbReference type="HOGENOM" id="CLU_089192_0_1_2"/>
    <dbReference type="OMA" id="NEVYIWC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1315-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM13" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13320" checksum="FF1B0ED1F5CD22F7" modified="2012-11-28" version="1">MAGMGQDAMIEKELADNFVGVNDGIHNAEGVAKVIYLEDGSNVLRLEDLRVTNGPDLYIYLSTDKQASDFVDLGRLKANIGNQNYDIPKGTDLSKYDIVLVWCKQFSVLFGSAELMTPATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEX5</accession>
    <name>K0IEX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57348">
        <property type="protein sequence ID" value="AFU57348"/>
        <property type="gene ID" value="Ngar_c04010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04010"/>
    <dbReference type="HOGENOM" id="CLU_1493021_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-400-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="180" mass="20411" checksum="5023479336F6B82B" modified="2012-11-28" version="1">MKDKSKGSIDAAKHMPRYDAGRINRAVEKANRDPAFIDYAVGQLGGLQFPAFKHKILDHARSIGADQDVVALFESLNGYMEFRDQYHLQKALQENVAAKKKEFQISDETRENPNVRTRLTTADASIKEREAVNESEERTDYPEVTPTAMSNFVCDRCGKQFQNQQDLARHRQFESGGTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF53</accession>
    <name>K0IF53_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57443">
        <property type="protein sequence ID" value="AFU57443"/>
        <property type="gene ID" value="Ngar_c04990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04990"/>
    <dbReference type="HOGENOM" id="CLU_3113190_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-497-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5369" checksum="A3319CDC6860EF26" modified="2012-11-28" version="1">MAGFPSSFILPVKKSNSNFDSKYDSAINSNALVQKYSDACFYLGISATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF57</accession>
    <name>K0IF57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58420">
        <property type="protein sequence ID" value="AFU58420"/>
        <property type="gene ID" value="Ngar_c14850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14850"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1449"/>
    <dbReference type="HOGENOM" id="CLU_2784238_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1483-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7252" checksum="076C2C33A52E7763" modified="2012-11-28" version="1">MADAMFMYAVMTGIMAFLVAVCFGARGARKRREPAEAAESHSTASSSSGGGTTRRIKKFKSDGTPVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFL1</accession>
    <name>K0IFL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58600">
        <property type="protein sequence ID" value="AFU58600"/>
        <property type="gene ID" value="Ngar_c16670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16670"/>
    <dbReference type="HOGENOM" id="CLU_2204193_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1665-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="12033" checksum="3DB1D0A70D0F67A9" modified="2012-11-28" version="1">MINDFALACAIDESPAYFTYHKETMLIIQSARDAKAGVRSFQFIEPFIEALISHESIHVVIKKFEGAEVSDSLDDIEVIVEHRGTKFQVTLNNMLFARDNSGIVTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFQ7</accession>
    <name>K0IFQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60191">
        <property type="protein sequence ID" value="AFU60191"/>
        <property type="gene ID" value="Ngar_c32760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32760"/>
    <dbReference type="HOGENOM" id="CLU_1412406_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3276-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="21075" checksum="9491D7AAD679F0D6" modified="2012-11-28" version="1">MPFGLWKKKAQPTVVDRQRQVDIGYAIKKLEQGDLSLIEGATVDGSVVLTMYNISLMEPRTARAMEGGIRGRIAKGLYFYVAQPQSPEPAEELVEVDRGTITITVEGLVFAGKSRHIGVGFGAIESISHSQNGITIVAKNNMQKLHFEGADRVVMSLKVQDRVYSQPLTGKLMRLLVEAVIRISFGADDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFT3</accession>
    <name>K0IFT3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60251">
        <property type="protein sequence ID" value="AFU60251"/>
        <property type="gene ID" value="Ngar_c33360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33360"/>
    <dbReference type="HOGENOM" id="CLU_1782545_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3336-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="16420" checksum="5166A1B299508CCF" modified="2012-11-28" version="1">MIDASLVSKINSRRVIVDACVSRDLANNLRNSGLVVRHVADINSALKDHEIAKMMHADEVLITRDYKFYRMLGEGRAILLAPGSNTVGRGAKLATRKDRHEVRRKNRLPSHIRIALRKKLAEEAKTGLLYMKILWGIMWLVLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFV4</accession>
    <name>K0IFV4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl5</name>
        <name evidence="8" type="synonym">rpl5p</name>
        <name evidence="8" type="ordered locus">Ngar_c17420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17420"/>
    <dbReference type="EnsemblBacteria" id="AFU58675">
        <property type="protein sequence ID" value="AFU58675"/>
        <property type="gene ID" value="Ngar_c17420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17420"/>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_2"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="66"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19399" checksum="4E831E1D2D413DBC" modified="2012-11-28" version="1">MSQQLQVQHDMKKISVDKVVINIGVGKSGEPIEKAKKALLELTGQQPAVRGAKKTVRDFGIHKGEPIGVVVTLRRDPAIEFLKRVIAAKKNVLKSSSFDNYGNISLGIHEHIDIPGTKYNPEIGIFGMDVNIVLSRPGYRIARKSRKSAKIGKAHRINKDDAVAFFRQEYGVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG01</accession>
    <name>K0IG01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57733">
        <property type="protein sequence ID" value="AFU57733"/>
        <property type="gene ID" value="Ngar_c07910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07910"/>
    <dbReference type="HOGENOM" id="CLU_3302865_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-789-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="39" mass="4306" checksum="E6301427E7F09628" modified="2012-11-28" version="1">MGACLLFFMFNNNNTTTFSTSPLLVGVYISLVQSNLFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGI4</accession>
    <name>K0IGI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58915">
        <property type="protein sequence ID" value="AFU58915"/>
        <property type="gene ID" value="Ngar_c19830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19830"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_2"/>
    <dbReference type="OMA" id="PGITTRM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1981-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14496" checksum="BB4201DFD5DA93AB" modified="2012-11-28" version="1">MPKESNGAALFCPLQGVIDIVSKKWALLIINEIGNHKRIRFSELKSELRGITSKTLTNTLDDLRENELVVRQAFNETPPRVEYGLTKDGIDLHRAIIPLLQWASSRKGAVVKECSCKALKSLQQSRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGQ0</accession>
    <name>K0IGQ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58013">
        <property type="protein sequence ID" value="AFU58013"/>
        <property type="gene ID" value="Ngar_c10710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10710"/>
    <dbReference type="HOGENOM" id="CLU_2930309_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1069-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6730" checksum="B679BD883B87AEB6" modified="2012-11-28" version="1">MMVVSYEIRAGKPAEEIIKASEENRYDLIVMGSSKIVSPVRILGSTSRRVLDNTRKSPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGZ6</accession>
    <name>K0IGZ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59130">
        <property type="protein sequence ID" value="AFU59130"/>
        <property type="gene ID" value="Ngar_c22000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22000"/>
    <dbReference type="HOGENOM" id="CLU_1987692_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2198-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="14075" checksum="FF55B7DF0CDE614F" modified="2012-11-28" version="1">MEKPTVLVCDDEADLLTMYAAALKKHYNVLTASSGRACIEKYTDHMLRSKNINVVLLDYRLGDSTGDDIACKIRDLGNARTILLSAYDLEREKVDELKSNNCIVDIMIKPVSMRVLLDRVQKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH50</accession>
    <name>K0IH50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57132">
        <property type="protein sequence ID" value="AFU57132"/>
        <property type="gene ID" value="Ngar_c01830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01830"/>
    <dbReference type="HOGENOM" id="CLU_2857207_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-183-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6715" checksum="831A4E39C546D885" modified="2012-11-28" version="1">MGAKKKKGQEDQALHEATHGQFGEEPRPEPMPNTEDKPSEGSSGGNIEDRIRAARKKSRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB5</accession>
    <name>K0IHB5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoD</name>
        <name evidence="4" type="ordered locus">Ngar_c23900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23900"/>
    <dbReference type="EnsemblBacteria" id="AFU59315">
        <property type="protein sequence ID" value="AFU59315"/>
        <property type="gene ID" value="Ngar_c23900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23900"/>
    <dbReference type="HOGENOM" id="CLU_038421_3_2_2"/>
    <dbReference type="OMA" id="AKWQPCN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="17629" checksum="B6880C4383212977" modified="2012-11-28" version="1">MHDEAVAHRLGLIPLRTDPGRFVMPHECDCKSTLGCSKCRVLLVLDAEASEKTLVVTSGELVSEDEMVKPVSKDIPIIVLAPNQKLKFEAYARLGTGKDHAKWQPTSAAIVKDGKDESEIILVIESNGALTAEEILTGAAERLAAKVKNFKQVVSSLKVPKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHD6</accession>
    <name>K0IHD6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59345">
        <property type="protein sequence ID" value="AFU59345"/>
        <property type="gene ID" value="Ngar_c24210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24210"/>
    <dbReference type="HOGENOM" id="CLU_2875210_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2419-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="6990" checksum="A3340EE7E4C6EC30" modified="2012-11-28" version="1">MNKVRIFSLAIVVLASLAIAVAWMTSIRDHTTPIETNSTSLNIMQKPRNYSINVTDSVSLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHH1</accession>
    <name>K0IHH1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57247">
        <property type="protein sequence ID" value="AFU57247"/>
        <property type="gene ID" value="Ngar_c02990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02990"/>
    <dbReference type="HOGENOM" id="CLU_1003319_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-299-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="32017" checksum="60C1E0FA5DA2007C" modified="2012-11-28" version="1">MVKKDLSVKELIALYDYLAVLVEAYPEPVRATDLAERAEKTKPAITKMRDRLMKVCDIKAMALEKGFILASSSDIFINLFLAFAANGRHRQFLSSKFVRTIIDSKNIHSMMVAKFPLYVKYFSQDDTNFIIHQAIAVASNMEPDDLKILVRALSREKPNFTDSDFLLRLQKVFDKLQFSINNKDELYTALLLRDKLFFLVRDYLWSQMEAMEILKSLELPERDAYTKVYKHTIDFYLRRIFDGLTEPIKKAAHKSSLDVDKINFSVGASVFVQTTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP7</accession>
    <name>K0IHP7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03950"/>
    <dbReference type="EnsemblBacteria" id="AFU57342">
        <property type="protein sequence ID" value="AFU57342"/>
        <property type="gene ID" value="Ngar_c03950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03950"/>
    <dbReference type="HOGENOM" id="CLU_096330_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-394-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS240" evidence="1">
        <location>
            <begin position="65"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="252" mass="30146" checksum="3FE4012E3A252B1C" modified="2012-11-28" version="1">MRKRTDPDIIRYGMYLYFNSRSFRLAARSLSPIRKRSHVSIWKWVQKYSSLADRFRTDRRLVGAIFVDETLLQIDGIDYWLWIAYEPAINTCLMMHLSRERTLFVCYRFFKQLQNRYGRKPIFTDGARWYNDACRWLRLRHYVYGTELKNIMERFVQHIKDRTECVLMTIFHAGKRIATGSMCGTGSGYSCCICMREQTECDLLHSWPGMAVKLTEPAFPVENISARWTRTNSIELFPRLKRRIRSLSRRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP9</accession>
    <name>K0IHP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipocalin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57347">
        <property type="protein sequence ID" value="AFU57347"/>
        <property type="gene ID" value="Ngar_c04000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04000"/>
    <dbReference type="HOGENOM" id="CLU_1197664_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-399-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="24424" checksum="83C098557F79679F" modified="2012-11-28" version="1">MVFCKKDSCRRTLKTAAIAFTALLLLLAIGAVEKFDDGNNTMMLAIPAASAQIPVPEDGSQQNTNVSSVQNTSSSSLVLRGLIGSTISTGQNANVTGSSIITGAQQANQSDYAVVGRWRMLVNESLVQRFAANLTVARVDGSEYHNNIIIESIGRPSEFAGNASNILTQISTDSSVPGAIAPIRLEIKDRVLEIADINIDENAIAGVEQQNILGIIDGQSIYGIIEFQGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV1</accession>
    <name>K0IHV1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c05240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57467">
        <property type="protein sequence ID" value="AFU57467"/>
        <property type="gene ID" value="Ngar_c05240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05240"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="OMA" id="QWIPAHE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-522-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="162" mass="17857" checksum="EE7C890E7C9015D1" modified="2012-11-28" version="1">MSRKPTGTTTRKNTSISEIMSDRLETINLLGSAKDAAIMMTNRNVSSLLVVDDDRKAVGIITERDLVRRVCTKDIPSRLVTIQNVISAPLKTVPAKTPIDKVADIMVRNKIRHVVVVTDEADKQEPVGIVSATDIVAFVRENSETMAQITREVMEALEREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY8</accession>
    <name>K0IHY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c26230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26230"/>
    <dbReference type="EnsemblBacteria" id="AFU59545">
        <property type="protein sequence ID" value="AFU59545"/>
        <property type="gene ID" value="Ngar_c26230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26230"/>
    <dbReference type="HOGENOM" id="CLU_130412_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2623-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="190" mass="20597" checksum="89DFC3A0C225A4AA" modified="2012-11-28" version="1">MARAAGLIGEEKKAGQKNLFDVAIIGAGYAGLSAALLFGRYLVSAVVFDGGRARNSMTRRVHGYPGLENSSPKALIGKMCADVAKYRSIIVVRSTVRAVKRRGRHFAVMTGALTFQARYVVIATGVQDIKPRIKNLEKFDDDGAWHCPYCDGLETAGRRLAVIVSGKNPLSFAKEFLGHRISRCFYASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ3</accession>
    <name>K0IHZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CRISPR-associated exonuclease, Cas4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26280"/>
    <dbReference type="EnsemblBacteria" id="AFU59550">
        <property type="protein sequence ID" value="AFU59550"/>
        <property type="gene ID" value="Ngar_c26280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26280"/>
    <dbReference type="HOGENOM" id="CLU_1280849_0_0_2"/>
    <dbReference type="OMA" id="YITGDRK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2628-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="1">
        <location>
            <begin position="42"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="24967" checksum="4D9166D1244B7BCE" modified="2012-11-28" version="1">MLGSRNLREIVEKNLDKLQEDLSVKIDKKNPDKIHAIEATGCTRFAYYERRDPLPSDNVSKISSLLGNAMRHSFGNTRGEYKVEGLSLEVNADLIIADEFVVRFEVVQTLPEVPHPRHLLYLNACLFAFNKDEGFLIYMTAEGKTVEFSVTKNNRMFEEVIRRARVLSTLLKDGKAPIVEPSELCLNCRYYERCYARKQVKDEGTGFILEEIFKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0II25</accession>
    <name>K0II25_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB family carbohydrate kinase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16550"/>
    <dbReference type="EnsemblBacteria" id="AFU58588">
        <property type="protein sequence ID" value="AFU58588"/>
        <property type="gene ID" value="Ngar_c16550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16550"/>
    <dbReference type="HOGENOM" id="CLU_961782_0_0_2"/>
    <dbReference type="OMA" id="CERTTRF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1653-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="307" mass="33663" checksum="2858C4215CAF86AA" modified="2012-11-28" version="1">MRIGIASHIVLDTIKSADGNLTESVGGPPCYCGMTGRRFGFDIRLATRVGSDFPQEMRKVLRDNDLILSDRQVSSSAPTTRFSLISESESRRLVLSAKCDPLTVDEIKDMKVDCWLASPVIDEVPPDVLAAIKQSRGRKDFVMLDPQGYMRIVTAAGSDGQVTLKDRLDLDLSGITAIKVDSQEMSALTGGLQGLEGMQALQSRGIRFVVSTEHRVIHLLYEKTHYWIKMRDVDTPDSTGAGDILCAAFTCSFLKEKDPLWAICFGAGAVRAALETRKVGLAKVPSMSKIEQSASYFYNTVGFQQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0II67</accession>
    <name>K0II67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Purine/pyrimidine phosphoribosyl transferases signature-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58648">
        <property type="protein sequence ID" value="AFU58648"/>
        <property type="gene ID" value="Ngar_c17150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17150"/>
    <dbReference type="HOGENOM" id="CLU_1458235_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1713-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="20694" checksum="C432CC677F12B1E6" modified="2012-11-28" version="1">MRALKDDEVLPNSQILTSEFIANLIRDNLNSLPFSNFFKAKPILVPTPRSSLIRPGTLWVPQRLANALAQRGLGKNVEPCLNRFKAVRKSATSQGDRPKAFEHYNSMEVQKIFPEPSEILLIDDIVTRGATLLGAANKLADAFPRAHIRVFAAMRTISPPDVFRSLFDPCVGNIELRGIDTFRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC1</accession>
    <name>K0IIC1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHHA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17800"/>
    <dbReference type="EnsemblBacteria" id="AFU58713">
        <property type="protein sequence ID" value="AFU58713"/>
        <property type="gene ID" value="Ngar_c17800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17800"/>
    <dbReference type="HOGENOM" id="CLU_042622_0_0_2"/>
    <dbReference type="OMA" id="AVGDMQE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1778-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="411"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="479" mass="52038" checksum="79F53675E08C34FB" modified="2012-11-28" version="1">MSDSAKLIEALKPFCEKLRSVVENGNEIAVITHLDADGITSGSIVASALRRMGARYSVRTISDMNPSVIERMKADNRDFYVITDLGGGWASHLRKSLGDKWVIIDHHQIPEEEILTDDDGQILNAWKFGIDGGRHVPAGGMAYMVASTLDRKNRDLSYIAVVSAVADRQDQGDKKSFIGLNTEILKTAQSLGLVSVDLDIMLTGRETRPLHEALAYTSCPYIDGLTWNREACYTLLKNAGIRLKDNGRWRVLAEFSQEEKSAVLDAIARFVATSNKTSTSVLDDLIGYVYTLAGEDKRSQLRDAREFSTMLNACGRIGKAGVGIAICMGDRNAMLSAGEEIVGEYRTTLRNYISTIFSEKWRLVDDGKNAFVNGDGLLAEDMLGAVSSLLSGSPSLSGRLLFVRTLTKDGTYRFSSRKCLGCDSKANLGLIMRHHAEAFKGAGGGHSAAAGCRIPSTALEDFLASLRAATSDPKFATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG9</accession>
    <name>K0IIG9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppD</name>
        <name evidence="6" type="ordered locus">Ngar_c18910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18910"/>
    <dbReference type="EnsemblBacteria" id="AFU58823">
        <property type="protein sequence ID" value="AFU58823"/>
        <property type="gene ID" value="Ngar_c18910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1875"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="320" mass="35398" checksum="3FCD0F331DCFFC0F" modified="2012-11-28" version="1">MPKLVVSGLKAYYATERGPVRAVDDVNFSLSDNESLGIVGESACGKSTLGAALMRSMQPPGKIVSGSIVLDGTDVSEMPASEFNSKIRWKKIAMVFQGAMNALDPVYTIESQLHEVLREHRFEGNMEEKIAESLRQVGLDLSVAKRYPHELSGGMKQRVVIAMALLLKPDLLIADEPTTALDVLVQAQIINLLKKLHRENGITVILITHDLALVSQIADKIGIMYAGQLVEVGSTSDIYKNPRHPYTQALIAAMPRLKSNDKKIHFVNGSPPSLLNPPHGCRFYDRCPHAMDACKKDPPEFKTDTGYVRCWLYENNKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ0</accession>
    <name>K0IIJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59715">
        <property type="protein sequence ID" value="AFU59715"/>
        <property type="gene ID" value="Ngar_c27940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27940"/>
    <dbReference type="HOGENOM" id="CLU_2802401_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2794-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7744" checksum="8D37B0E416654C1A" modified="2012-11-28" version="1">MVANCQVLIMDNDEIRYKLLLPLYNRFYDEGYFSHNIVTDGIINESGLTLDSRVLKHILISLKGIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT3</accession>
    <name>K0IIT3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c29520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59870">
        <property type="protein sequence ID" value="AFU59870"/>
        <property type="gene ID" value="Ngar_c29520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29520"/>
    <dbReference type="HOGENOM" id="CLU_2177965_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2952-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="2">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12540" checksum="EF234951969D2B95" modified="2012-11-28" version="1">MEIIDKDSANARSAHADTDRPPPDAQSMKLYHGNIDWDVAKRLLHMIYLHGPIKKTRLAMKTAVNSSTCTRYVTWLIEIGWVATNNFDEFSLTEAGLAIYKRIKWQDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT8</accession>
    <name>K0IIT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58993">
        <property type="protein sequence ID" value="AFU58993"/>
        <property type="gene ID" value="Ngar_c20610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20610"/>
    <dbReference type="HOGENOM" id="CLU_2730545_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2059-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8248" checksum="77265BF37021E1E4" modified="2012-11-28" version="1">MRMGKREVHEFLHPLEPVYKECLYCGERKSMVCLTCGYCYECHPAIEQMERRLLAKAPNVIISTLEDIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT9</accession>
    <name>K0IIT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoesterase PA-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c10900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10900"/>
    <dbReference type="EnsemblBacteria" id="AFU58032">
        <property type="protein sequence ID" value="AFU58032"/>
        <property type="gene ID" value="Ngar_c10900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10900"/>
    <dbReference type="HOGENOM" id="CLU_072573_10_3_2"/>
    <dbReference type="OMA" id="SGFAHES"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1088-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="92"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="26416" checksum="7561CF8EFDE669CC" modified="2012-11-28" version="1">MSAAATAATRPPWMIRARSMHFVALIAAFVAFSTLVASGVTLGADDAASRYFKSIHGNAGLDAVMIVITSMGDVTTLFIFGIIITIIRRTRKAGMVFLIALIVIVVLVMYIKPLVGREIPPYTFEPALELPSNFSLENDSLAPFAAGFSYPSGHAARATALAFIVGYAIYNKSRKAGYAIWAFPIIIGITRLYVMQHYPTDIIGGFLFGGMVSVVLASAMKLEQPFFMSRIKGKEDQPPQGEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW7</accession>
    <name>K0IIW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59033">
        <property type="protein sequence ID" value="AFU59033"/>
        <property type="gene ID" value="Ngar_c21020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21020"/>
    <dbReference type="HOGENOM" id="CLU_2550381_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2100-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9410" checksum="29493978AD46E668" modified="2012-11-28" version="1">MLFIIIDRPVAPIDRELRRKITAIVRFKMAVCFLVKRLACIKTASIKELILISTCSIGNAHIYAHMFLQWLNMVSAATLHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ49</accession>
    <name>K0IJ49_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60040">
        <property type="protein sequence ID" value="AFU60040"/>
        <property type="gene ID" value="Ngar_c31240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31240"/>
    <dbReference type="HOGENOM" id="CLU_2930319_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3124-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6915" checksum="741BADC762C41C2B" modified="2012-11-28" version="1">MLQIMHKAFTTADVAKAVIQELINEELLAREPGTKLYRITQKGRKWLDTMQNSLSTQLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ92</accession>
    <name>K0IJ92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60080">
        <property type="protein sequence ID" value="AFU60080"/>
        <property type="gene ID" value="Ngar_c31640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31640"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3142"/>
    <dbReference type="HOGENOM" id="CLU_1412304_0_0_2"/>
    <dbReference type="OMA" id="MAGVLWT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3164-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="20825" checksum="751042273FDBE572" modified="2012-11-28" version="1">MELVIEEKQHRIISPYSLLTLLVPVVALVAVLLYGNLLALNYVHVLMGGTWTGIDLFMGIVMSQVMKGLEPQARTQVIKKLVPVMLFLMPALAAVAITSGITLAQRMNMPTLESPTIIAAVIIVIILSVQGFGMIMPTEIRVFLELQKKEPNRDKIIRWGMRNIKLAGSQGVFQVALIFVMANLAKGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB8</accession>
    <name>K0IJB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60115">
        <property type="protein sequence ID" value="AFU60115"/>
        <property type="gene ID" value="Ngar_c31990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31990"/>
    <dbReference type="HOGENOM" id="CLU_2327346_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3199-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="10817" checksum="262BE57EC5BA6D7E" modified="2012-11-28" version="1">MIELPITRLKLIPVLSFFVATDENRKKVTVGRVYAISTLLAVIIAIPAVTVTLIMHYVIRTDFFITLTAGLITLFIAMGFGYKLSKKFARVPGGQSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC3</accession>
    <name>K0IJC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disulfide bond oxidoreductase D family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccdA</name>
        <name evidence="3" type="ordered locus">Ngar_c32040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32040"/>
    <dbReference type="EnsemblBacteria" id="AFU60120">
        <property type="protein sequence ID" value="AFU60120"/>
        <property type="gene ID" value="Ngar_c32040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3189"/>
    <dbReference type="HOGENOM" id="CLU_053225_2_0_2"/>
    <dbReference type="OMA" id="TSLTPCM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="257" mass="27213" checksum="638907872FBA8049" modified="2012-11-28" version="1">MVETSVLVFALAGAGSFFSPCILPIIPAFVSYLSGTTLSEIQGQNQNAGGTSVTVKKSTRLNIFLNTVYFVLGFSLVFAVMGVILNSFLANIGTGFQATLQTIGGGVIIAFGAYLVLSTKIRTLNFERRMTAANLPRFKTTYLTSFVFGAAFASGWTPCVGPILGTTLTLAATSPGAAYNSLLAYSLGLGVPFLITGAFFSQSTKIIKKMVKYLKYFNPIMGAILIVLGVLVITNQLSIIGNFPLASEIINLERGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD2</accession>
    <name>K0IJD2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14310"/>
    <dbReference type="EnsemblBacteria" id="AFU58367">
        <property type="protein sequence ID" value="AFU58367"/>
        <property type="gene ID" value="Ngar_c14310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14310"/>
    <dbReference type="HOGENOM" id="CLU_063810_1_0_2"/>
    <dbReference type="OMA" id="LWIAAEH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1429-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="52"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="291" mass="32797" checksum="F54E8F2C9891713A" modified="2012-11-28" version="1">MAVNNNIDSLIQDWKSSVVKDVTSSDDTDRLAEYALHLARILAYPNLDVPATLAKIDSMGDEVAQLIKKTLSTPRRPTQIIDKINDYLFNVHKFKANTDDYYNPLNSYLNVVIEHKTGIPITLAILYLRIARAASFKMHPVNFPGHFLIKHVLEDNSGEIIVDPFNGGRIMDDYSLKALLDQTYPRQNIPLTHALVEKATSAQVIIRMLNNLKGSYYEAQDIDRYGIANEMVLAIDQYNPDAIRDKGIMLLKKGDPSEALKILNSYLEINPEAEDADDILDIIRQIRSGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE5</accession>
    <name>K0IJE5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23320"/>
    <dbReference type="EnsemblBacteria" id="AFU59258">
        <property type="protein sequence ID" value="AFU59258"/>
        <property type="gene ID" value="Ngar_c23320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23320"/>
    <dbReference type="HOGENOM" id="CLU_613420_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2330-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="436" mass="46728" checksum="30D3B3929A493545" modified="2012-11-28" version="1">MSKKHVRLLPAVVAIVILIASITQQAYAEFSFHNQFSHVDDNGILHILGVIRNDSDTAMENVLITVSFYDSEGNLLNEFSRVPALEAINAGESSPFEILYLDQGAVDRVENFTLSATGQTTTESKEKQLKIISANSRLDLLGTYYINAAARNEGEETATNAIMVATLYDRDDRVIAVSKALAEAGPGSSNITAGSQAPFGIAITERTQTYRAVSYSLVAYSDQYISDTVVLQTSGHGLSSGNNNQTQSGCLIATAAFGSELAPQVQQLRSFRDGIALKTSAGSSFMNVFNAWYYSFSPSVASYERHAPWFQNTVRTLIHPLLGILTLSTSIYDSLAFFFNNELGIVASGITASSLIGLVYFAPLGIALGIAGRRKRWNMSKAKTVLACSWAASIVAIALAELAGGIMGPVMMFGTSLLVLSTISTAVIAIARAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH7</accession>
    <name>K0IJH7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58427">
        <property type="protein sequence ID" value="AFU58427"/>
        <property type="gene ID" value="Ngar_c14920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14920"/>
    <dbReference type="HOGENOM" id="CLU_434537_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1490-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="629" mass="67343" checksum="04BAAE362553719B" modified="2012-11-28" version="1">MSIALLLSLATAATIVGTRTTTMNNTAGTESAGLFAGAYAATQQCEDTQIGKITASASTRSPTNAIDDNLDTRWTAQGKGSWIKADLGEHKVVCYIDIMWYKGDSRIYSFTIYTSENGSEWDTVYHGKSSGRTLDTERYDFADTTARWVKVRLDGNQWNYWHDITEIDVYTAAASAADTKAPDVEITSHANDSTIISSSSQITVQGTASDDMSGVKIVEVSVDGRAYVGATPKASGDWSSWSVSVDLGTPGTHEIVPRATDNAGNQALNPIRVTFQKDTTPTQDTTNPTVAITSPADGSTVSANEGKITIQGTASDSGSGVKMVEVKVNNGAYVEAVPRATGDWSSWTATVPVSSGSASITSRATDNAGNQGTSSISVTVAADNNNPPPPAATADKYFMATMLQYVDTDKQVNIYKPNMISSDKARIHVGLNKQVTNAQLNGLLSLPGSHGMEFFSLKEIKANAPHLKAKGIEFIDYDLEPGSGHSPSSDLSDPVASIRAASKAAHDNGLLFQCSPSKKITTNYGAQLAPYCDQYHIQAQSLQGSPAQYESFVKSTVTKLRQNNPDIVISVQLSTQRESANGMSLLETFKHDFARVADDVDGVSLWFSNNDSSLNVVESFAKWFDANYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL7</accession>
    <name>K0IJL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58472">
        <property type="protein sequence ID" value="AFU58472"/>
        <property type="gene ID" value="Ngar_c15380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15380"/>
    <dbReference type="HOGENOM" id="CLU_147146_0_0_2"/>
    <dbReference type="OMA" id="RISEQYI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1536-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="15841" checksum="D3E90206F7081415" modified="2012-11-28" version="1">MRLKLEEWTSLASLALSIMFVVLLLSFYNFLIGPEGEGPEAVVDPGSLVLQEIFISGAPSLALAGFAFGMAKTFGTKIGGTMLVASGVIMIAGMIAGIPLLARISEQYIVGVVGYVPYFFMTAGAGVAAMGGYLIAATKRRPISSDLDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN8</accession>
    <name>K0IJN8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dienelactone hydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25100"/>
    <dbReference type="EnsemblBacteria" id="AFU59433">
        <property type="protein sequence ID" value="AFU59433"/>
        <property type="gene ID" value="Ngar_c25100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25100"/>
    <dbReference type="HOGENOM" id="CLU_1840647_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2509-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15599" checksum="41271A624646E3E7" modified="2012-11-28" version="1">MIHEWWGLNQNIKDMTEQLANEGYVVLAVDLYNGEVATESSRAGQLAGSVRNNPGEAISNLNAAVEYVSSLPNVNSSRVASLGRCLEYSALKTSQSRSTQSTRSRTGRQRHHKPDLHLRRGRARIRKPIRRQLCARRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJY7</accession>
    <name>K0IJY7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60430">
        <property type="protein sequence ID" value="AFU60430"/>
        <property type="gene ID" value="Ngar_c35170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35170"/>
    <dbReference type="HOGENOM" id="CLU_3039187_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3518-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6639" checksum="03A91C43525AA03C" modified="2012-11-28" version="1">MMPEKKDYALYDDATIERMKHYFRQEDHDALLRYIKTHGMRRHFDVFEEISSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK31</accession>
    <name>K0IK31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphate ABC transporter, periplasmic phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35770"/>
    <dbReference type="EnsemblBacteria" id="AFU60490">
        <property type="protein sequence ID" value="AFU60490"/>
        <property type="gene ID" value="Ngar_c35770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3584"/>
    <dbReference type="HOGENOM" id="CLU_2550388_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3578-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8874" checksum="3F696B48CE917055" modified="2012-11-28" version="1">MEKVPGAVHIPETIGSIVVSYNLSEFPEKGLKLTGPILADIFLSKITEWNDPKIQELNPTISLPSQSIIVAHRSDGSGTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK96</accession>
    <name>K0IK96_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbiG</name>
        <name evidence="4" type="ordered locus">Ngar_c18040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18040"/>
    <dbReference type="EnsemblBacteria" id="AFU58737">
        <property type="protein sequence ID" value="AFU58737"/>
        <property type="gene ID" value="Ngar_c18040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1782"/>
    <dbReference type="HOGENOM" id="CLU_028397_0_1_2"/>
    <dbReference type="OMA" id="GIGCNRG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021745">
        <property type="entry name" value="CbiG_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11761">
        <property type="entry name" value="CbiG_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_N" evidence="2">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_mid" evidence="3">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="231"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="355" mass="38727" checksum="080A0EE6BB2D8666" modified="2012-11-28" version="1">MTKTAIVAITKHGIEIARRIKQKMPEVEIYVPAKHSDGVTDINWFSEQSTQLVGSLFKTYDALICIFSLGAVIRMVAPHLVDKKSDPAVVVIDDRANHVISALSGHLGGANALARLVASFLGAQPVITTAADVNETIAVDLVGREFGWTIENFENVTKTSAFMVNEEKIAIYQDAGERNWWHAPLPKNVAVVGSIEEIKSPEFKAGLVISDRAISDPEIISKSVIYRPKSLVVGIGLHWDTSKDVIESGIMTVFKVKGLSFKSIRNISSINRGAKVKGLEEFSKQYGIPIEIYDKDKLASVNVPNPSQTVQKFEGTPSVSEASSLLSSKGELVVPKQKFSPNLTVAVSRINFNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF5</accession>
    <name>K0IKF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59728">
        <property type="protein sequence ID" value="AFU59728"/>
        <property type="gene ID" value="Ngar_c28080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28080"/>
    <dbReference type="HOGENOM" id="CLU_3130975_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2808-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5483" checksum="2F0E66E31CA69FFC" modified="2012-11-28" version="1">MKGKAAGRSAKGSAARRTGKSSRTRMKDRQRHVKNREILETRKTSIGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKJ2</accession>
    <name>K0IKJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chlorite dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cld</name>
        <name evidence="4" type="ordered locus">Ngar_c28790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28790"/>
    <dbReference type="EnsemblBacteria" id="AFU59798">
        <property type="protein sequence ID" value="AFU59798"/>
        <property type="gene ID" value="Ngar_c28790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28790"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2855"/>
    <dbReference type="HOGENOM" id="CLU_076582_0_0_2"/>
    <dbReference type="OMA" id="WIVKEEP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="236" mass="27336" checksum="03121A79A9A33CF9" modified="2012-11-28" version="1">MSSETSSPPAPEKQAAVTIFLNFSFFKVDPKWRWLNEIGKEEAAKEFASLVDVANTKMKVRTYSTLGLREDADIMFWMISDTVEKTQVMASKIYSTVLGKYLTQSYVFLSAMRPSVYSSKVIPSFMTDAQPLKYCIVYPFVKSREWYLLPFEERKKMMDEHIAVGRKFPQVRLNTTSSFGLDDQDFMLAFETEDLMAFQELIMQLRETKVSKYVVRDTPMIVCVHREIEEIIKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKN4</accession>
    <name>K0IKN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59868">
        <property type="protein sequence ID" value="AFU59868"/>
        <property type="gene ID" value="Ngar_c29500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29500"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2924"/>
    <dbReference type="HOGENOM" id="CLU_862260_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2950-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="322" mass="35006" checksum="F5FCE048326F07E2" modified="2012-11-28" version="1">MNYALWTEGSSVPYILKFAILQYGTLTTTSNQNSPTKTDYYQREKRIIESGDMVKFAFYYDGSNILYRNSIDDDKTWSGTAVSTGSGVLASDTFRWTVIATTYQDNEYAVLLYWTPAGSNMNFYVLRGQIANETITWSSPILLGYTFANSAACGSGGACAAVAAATDIDGKIYAAFSYGSGGSSTYSYQIMRSVDGGLNWAVSLAQIDNVSTERPVMSITGLNGSKMLFVYALYESSDLKYRVFDGTNWGSAQSASGTDMGVNTVKQISAATMNSTRTAYVAYLSGGNSGTMHVERFSNLTEPSTERRQLWALAVTVCHPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKW0</accession>
    <name>K0IKW0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="1">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">carA</name>
        <name evidence="4" type="ordered locus">Ngar_c22470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22470"/>
    <dbReference type="EnsemblBacteria" id="AFU59177">
        <property type="protein sequence ID" value="AFU59177"/>
        <property type="gene ID" value="Ngar_c22470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2227"/>
    <dbReference type="HOGENOM" id="CLU_035901_1_1_2"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="428" mass="47429" checksum="08A5115834FB02FF" modified="2012-11-28" version="1">MRVQKIPTLQQTYTGYAAKLILEDDSVFDGIGFGYPSEVAGEVVFNTGMVGYTETLTDPSYRGQILCMTYPLVGNYGVPSFNIKDEYGLPKFFESDKIQVKALLIHDLSDIASHWSCTRTLDQWLYEEKIPGIYGIDTRALTKKLRVHGVMMGAVVVSENAIDEARLKRALSSAKYEGLNFMPEVSTSEPKEYGDKSKDCIVVLDTGVKYSIIRNIIRTGYRVVRLPWDATYEQVMSYNPKGVVISNGPGDPKVCTDTIKTASKLIKESTPTLGICLGNQILALAGGANTYKLKFGHRGQNKPCVDRRNNQVYVTSQNHGYGIDPKTLGKTGFKVWFENADDDTVEGIEHKSKPIIAVQFHPEASPGPYDCMYVFDRFKEIIGNGVKPEPAVAAAATTKAAKARPKKKTTKIAAKKKKKKEVRRGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL11</accession>
    <name>K0IL11_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59247">
        <property type="protein sequence ID" value="AFU59247"/>
        <property type="gene ID" value="Ngar_c23210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23210"/>
    <dbReference type="HOGENOM" id="CLU_1280833_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2319-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="215" mass="23985" checksum="88A556065A1AEBFF" modified="2012-11-28" version="1">MQVKTWLQRLTDESNLWFNAVKAEDEGSFQSAISYYMKDALECIRQHSLVRAALSCSCAANCLARMGAWSPARMLYSEAGRLYVENSEIAMSESIREALWSLQEAFENYALAGDDSAADTVRERYVMLAARTSPFSRAGQVAEDLESRRVESIKPDPRKKEASIPEELAGEIENFVRARRSGTARTDDSFDPSYVMRSIGVNNGGSRLDEKSIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL78</accession>
    <name>K0IL78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c32930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60208">
        <property type="protein sequence ID" value="AFU60208"/>
        <property type="gene ID" value="Ngar_c32930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32930"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_2"/>
    <dbReference type="OMA" id="LINWLPM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3293-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="24"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="450" mass="48761" checksum="AC7D03AB37F8504F" modified="2012-11-28" version="1">MDVLIDDLAKRIDGLKGIPLASSAIFAISFSSFFAFYDITNYAYIAPVLKSTFSVGDNEIAVGASTTVIGYVIGAFVITVFADSNGRRPALIASTLILGIGSLLAAFSQDMVQMSIFRLLTGIGIGSEIAVASAYIGEMSPKSKRGKYTSIVIVLGWVGLASSGPISLMLIQQGNNVAGIDGWRAVLAIPSIAAFLSLLFRIRMPESPRWLLSKNRLGETNTVLASLNIRPLERKHDYAATTFAKNNHRRKNRWHHLLKNRTIATRIALLIAVWVCIFVPVYASLLLVVEYINQGYSLTDSISINIISGIGFVVGGILSIFISERLERKYQILIASIIMAIGFILRGILIHDYAGLVIAGFIAFGANAWLVSSLYAYTAEVFPTRIRTFGFGIIEGSSRAISSIGPFIFVLLSPFGFLNTMVAISLFCFGAATIILIGPHTRGRSLESLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL98</accession>
    <name>K0IL98_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60263">
        <property type="protein sequence ID" value="AFU60263"/>
        <property type="gene ID" value="Ngar_c33480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33480"/>
    <dbReference type="HOGENOM" id="CLU_1870807_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3348-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="15887" checksum="446CFF1E394B8BD6" modified="2012-11-28" version="1">MITESPEGTDELPPCQAVRNNNKNNGESNKKYQDPAYDDKTIEGLMNYFKFGTYGELRWFLQCVKRHLEFGQGVMQYPVFLYVIQQCVVAVFNFKVLLHCLDSFIVIQVMMVVSAAQPLLFFKNFRVVSRHAIFWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA0</accession>
    <name>K0ILA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00140"/>
    <dbReference type="EnsemblBacteria" id="AFU56964">
        <property type="protein sequence ID" value="AFU56964"/>
        <property type="gene ID" value="Ngar_c00140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.15"/>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_2"/>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-14-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="275" mass="30320" checksum="52361515CC13AAD1" modified="2012-11-28" version="1">MEKKKKKRVALVQMRSSEDKQKNLDKSIEFIAEAAAKGADLVCFPEFQMAFSPGSQSAAQLAAGIAETVRGNFVSKLAEAAKKNNIGVIATIYEKSGRFQRVYDTAVMIRPAGKVSSVYRKLHLYNALGFKESAKLVPGKNIAKPAKTNAGSVGLLICYDLRFPELSRILTVKGADFLVAPSAWVAGEMKEEHWQTMVKARAIENGSYVVAPDQVGNIYCGRSMAVDPFGVVLVDMGQREGVEVIEIDKSRVQQVRKSLPLLKNRRTDVYRLLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB9</accession>
    <name>K0ILB9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="12" type="ordered locus">Ngar_c24950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24950"/>
    <dbReference type="EnsemblBacteria" id="AFU59417">
        <property type="protein sequence ID" value="AFU59417"/>
        <property type="gene ID" value="Ngar_c24950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2473"/>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_2"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="183"/>
        </location>
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            <end position="330"/>
        </location>
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            <begin position="26"/>
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        </location>
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        <location>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
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        <location>
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        </location>
        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="253"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="334" mass="37303" checksum="181B098905F6A40F" modified="2012-11-28" version="1">MPAKKWLDNQVSLAPVKDQTVAVIGYGIQGRAQASNMKDSGLNVIVGLRKGGKTWKQAEAEGHKVMEVAEAAKAANIIHILIPDMEQADTYKKEIAKHVTEGKALSFSHGAAIHWKWIVPPKNVDVIMVAPKGPGQRVRELYQEGFGTPSLVAVYQDHTGKAWDRVLAMAKAIGSTRPGVLQTTFKEEVETDWFGEQVDLCGGAHAMVMNAFETLVEAGYQPEVAYFECLHELKLIVDLIQKYGITGMYNRVSETARYGGLTRGPRVIDKEAKKKMKEALKEIQSGDFAEEWVSKYKKEGKNSFARYMKEIENHPVEKVGREMRKMMWPDAPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD6</accession>
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    </protein>
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        <name evidence="2" type="ordered locus">Ngar_c25190</name>
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        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23510" checksum="4BA84F3A308D6AA6" modified="2012-11-28" version="1">MSGQQQPPSTPDAAAAGHYSHGEHGQQPRKYEEYAYVLDFTPRGKSITVRGREGVIIQAIGEERLTLLELLGVQNVTVEIGERLYIGREGRDKVASVLGRLEYNDISQAAKNELPNIVEKIVVANEKRFVEYINVSQPITPRIHALELIPGIGKTYMMTIIKERDKKKFENFADLQNRVGLRDPAKLVAKRIIEEIMGQARMNLFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF7</accession>
    <name>K0ILF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tRNA (Guanine-N(7)-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25450</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Thaumarchaeota</taxon>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1425131_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="188" mass="21114" checksum="E972BAC3C7CA5ADB" modified="2012-11-28" version="1">MLDKLASSYPRVIVELGMGDGRLLEALAKHDSSSLYVGIDLDNAQCKQAQSSIALSNVIILSGSFEDIVPTFPDGSVDRFIAVLPDPEFIDEKKEGRWKPFYKEVYSKLKPSGTLELVTEITDELLRPVSDEAYVKWVAWLRASFLSIGFDLTKQHEGAPAQYSSRCLDQFRGDPERIRMVTLELAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ9</accession>
    <name>K0ILJ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative quinoprotein glucose/ sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35550"/>
    <dbReference type="EnsemblBacteria" id="AFU60468">
        <property type="protein sequence ID" value="AFU60468"/>
        <property type="gene ID" value="Ngar_c35550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35550"/>
    <dbReference type="HOGENOM" id="CLU_677373_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3556-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="52"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="426" mass="47032" checksum="5935849FDF0072C6" modified="2012-11-28" version="1">MYVLAAGAAVGIVAVILFLALASDSSIAHEQEKNMPLLHDAGLDIELVAEGLAYPTSMRFLDDDSGSILVLQKNDGQVRLVSGGRLAEEPVLQVDVANEAERGLLGIAVWDGGNDTTSVFLYLTEVDDNSGEIRNRVYKYLYDENEKTLINRARILDLPGEPGPFHDGGKVTIGPDGNLYAVIGDVNAGGGMLDNQILGRLPDDKSVVFRVDRDTGMPVEGNPFYYNNYTGDMEKLRRYYAYGIRNSFGLDFDPLTGRLWITENGPDSYDEINVVEPGFNSGWHKVMGPISRTNATEGDLVLFNGSQYRDPVFSWRAPIGVTDIEFFDSPKLGEKYQNNIFVGDINYGNLYFFKLNKERDGLELDSINGLADLVADPVGDDMLGEASPVIIGERFGRITDIETGPDGYLYVLTYLDGKIYRITERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT3</accession>
    <name>K0ILT3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03350</name>
        <name evidence="2" type="ordered locus">Ngar_c03660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57283">
        <property type="protein sequence ID" value="AFU57283"/>
        <property type="gene ID" value="Ngar_c03350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57314">
        <property type="protein sequence ID" value="AFU57314"/>
        <property type="gene ID" value="Ngar_c03660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03350"/>
    <dbReference type="KEGG" id="nga:Ngar_c03660"/>
    <dbReference type="HOGENOM" id="CLU_942046_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-335-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="295" mass="30902" checksum="39BC5136BC078A14" modified="2012-11-28" version="1">MAIIYHKANQQLPQDLSALGNLKVAIQENSAATTSQDVNVKSVSGVAQTARDWSSDLSNLPLIKAKTDNLDTALSTRATEATLSGVKTQTDKLSFDVGNALKIQNPPNLDTALSTRASETTLASVNTKIGNIEADADALTNDAIKGVLRTLGDAGATPANNTGKTVLARLVDIQDQLKLERWGKNIEPAWVHGAETTNPADGTALVTKAVSAAKTGFIYGFYITSAEARDFKINWTSGGVAKSIRIVHASKGTMFFTDKTPVNEGLGADASTNITITNVGAGAGIFQAGLLFAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU0</accession>
    <name>K0ILU0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03970"/>
    <dbReference type="EnsemblBacteria" id="AFU57344">
        <property type="protein sequence ID" value="AFU57344"/>
        <property type="gene ID" value="Ngar_c03970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03970"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_2"/>
    <dbReference type="OMA" id="PFHMLQR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-396-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="24273" checksum="340554A1775285EB" modified="2012-11-28" version="1">MREPVIIFDLDGVLVNSMPTHVQAWKAAFAKITGLEVSERDIYLLEGMRGMELVEKIFEQKRFPDRSLVRSVHDEKSRIFKSIRSSEPFEGVREMIDEIECAKAVVSGSTRNDVETILEEAFGKDKFDVIITADDIEKGKPDPYAFLEALRRMKVGSAKDAVVVENAPLGAMAANKAGISCYVALNNTPLKRSDFAGIISQERIFEKTSLLRTVLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ6</accession>
    <name>K0ILZ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS and zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c05210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57464">
        <property type="protein sequence ID" value="AFU57464"/>
        <property type="gene ID" value="Ngar_c05210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05210"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-519-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015318">
        <property type="entry name" value="Znf_GAGA-bd_fac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09237">
        <property type="entry name" value="GAGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="21173" checksum="D551F812275F1D36" modified="2012-11-28" version="1">MGDVAEPDFICLPEDMLVGEAVKVMRDKDVSSILVSKPDKKVIVLDDASPAPSTVSLSHKKQYVGILTERDILYRVLAENRGPYKVTLGRIMSSPLVTISEDASVRDAIGLMESKRIRRLPVVNSRDEVIGLVTLKTVIGNMPSHNINLAELESSRSVAEKEAVCPYCRSVIRQDSTMAEHISGTHMQKQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM07</accession>
    <name>K0IM07_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57489">
        <property type="protein sequence ID" value="AFU57489"/>
        <property type="gene ID" value="Ngar_c05460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05460"/>
    <dbReference type="HOGENOM" id="CLU_159743_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-544-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14526" checksum="BF7E8C9423D2E2FB" modified="2012-11-28" version="1">MTITTMKMLDMTTPAVSRSGSGPFSGRRRGLGTGRTTKRGGRSAGYHEPTLPTIQMVEAAIKEAKEYPSKYKLWRSLPKSMQYQTLEKVLNYLEASNKIMIDNKDGAIIWVFADNPKLEKLLEESTRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM25</accession>
    <name>K0IM25_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59922">
        <property type="protein sequence ID" value="AFU59922"/>
        <property type="gene ID" value="Ngar_c30040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30040"/>
    <dbReference type="HOGENOM" id="CLU_161196_3_1_2"/>
    <dbReference type="OMA" id="FRVNVKI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3004-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7443" checksum="F13DF4B2AFD1709B" modified="2012-11-28" version="1">MSSVAKIIEVIGVSSKGWEDAAQTAINEAKKTVHGIHGIKIQDMTADIDNAGNIVRYKTTVKISFGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM35</accession>
    <name>K0IM35_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6438 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c30410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59957">
        <property type="protein sequence ID" value="AFU59957"/>
        <property type="gene ID" value="Ngar_c30410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30410"/>
    <dbReference type="HOGENOM" id="CLU_2340273_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3041-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045497">
        <property type="entry name" value="DUF6438"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20033">
        <property type="entry name" value="DUF6438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6438" evidence="2">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10572" checksum="F9C4C6B21A0C6ECC" modified="2012-11-28" version="1">MAAPVTAGLAVGTAFVILFAFFAGNNIIIPLHKDHDSAIITLERTVCYGTCPDYSLTIYGNGAVVYEGHRWVAVTGRQTSSIPQQEVKELVDYFHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA7</accession>
    <name>K0IMA7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57704">
        <property type="protein sequence ID" value="AFU57704"/>
        <property type="gene ID" value="Ngar_c07620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07620"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-760-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12946" checksum="89963386330BA1BD" modified="2012-11-28" version="1">MKPNNFAMKDWHLEHVEKVIVRFVRGISPDASSFEKRNYKKYSTVSSCAKQIEYDIKHGVTMDEVLNVVHRIRHEKQFKDLQKNPESLQRLDELERQISAPKKVATTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF8</accession>
    <name>K0IMF8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60237">
        <property type="protein sequence ID" value="AFU60237"/>
        <property type="gene ID" value="Ngar_c33220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33220"/>
    <dbReference type="HOGENOM" id="CLU_1056085_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3322-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="263" mass="28821" checksum="8691C18497918EFF" modified="2012-11-28" version="1">MTTALLLLSVFAISQGGAATEEAFATTEKALVATALQFVDTSKQYDIFNPHLSTSPDRVRIHVSLDKSITSEQLDMIHSLPPEQKGAEFFSLAEIKEFAPKAKALGFTYLDYDLEPGKGHSPAKDLADPVKSVREAAEAAHAAGLLFNVSPSKALTTEHGTEFAKYVDMYHIQAQSLQDRPSSYLSYVKETASKLRSANPDLSITVQLSTTRGAAPGLTLQETFKENWNNVKPYVDGISIWFSDSTTDDLQAFASWFDVHGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG5</accession>
    <name>K0IMG5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57879">
        <property type="protein sequence ID" value="AFU57879"/>
        <property type="gene ID" value="Ngar_c09370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09370"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.894"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="RSFMYID"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-935-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="349" mass="39300" checksum="7685E9491BAE0D93" modified="2012-11-28" version="1">MLPEPSKWADISVLVTGGASFIGSHLVDKLVQLGAKVTVIDNLSSGKLENLAHSISKIKFIKADLEYITKQEIIDMFKGHERVFHLAAVHGGRGFIATHPADVSSNLSIDHHVFEACTDAGVEKVVFASTACVYPTKLQKKIGSDYKLKEVDSNPFDLDGFMSADIEYGWGKLMSEIQMISFKKQYGLKGCPVRFVTAYGPRENETHAIIALIYKAVEKMDPYEIWGDGQQERDFTYVEDIVEGTILASERISDCTPINLGTGRRYKIIEVVEMICKILNWRPSRFKFDTSKPVGALSRALDNSRAYEMIEWKPRFTLEEGLQKTIDWYVKTHKKEGNVSSKLLLEHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ9</accession>
    <name>K0IMQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monovalent cation/proton antiporter-2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c35840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60497">
        <property type="protein sequence ID" value="AFU60497"/>
        <property type="gene ID" value="Ngar_c35840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35840"/>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="OMA" id="MEKFFVV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3585-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="2"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="392" mass="41188" checksum="03263A2645F08E15" modified="2012-11-28" version="1">MVVAAIMLAITFKLKQPMVIGYIAAGMIIGPYTPPFSLVRSPETLNLFAELGIIMLLFVTGTEFPIAKLRSVGRISIVTALAESIGTLLIVFFIAQNLGFSFYDSVFLALALSITSTVVTIRILEDVGLIRDKSSTLILGMLIVEDIVAISVLGVMQSFVTAGGNLSIANIAITLGIVGGFIGGVTIIGSKFVPRVIDRAGRTNDYALLLITILGLAFGLSFLANGLGMSVVIGAFLAGVLVAESKSAAVARIITIPLRDMFAALFFISIGALMDVSLIPTYIVSAIILILTSFASKFLIVTGILVRGGYDNTTALRSGLGIAATKGELSLVIGKGGQDVGAISSSVLPMLGVVTIVTSFIGPFIIRVGSRFKLSEPTEEVDSKKEKEKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW7</accession>
    <name>K0IMW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58344">
        <property type="protein sequence ID" value="AFU58344"/>
        <property type="gene ID" value="Ngar_c14080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14080"/>
    <dbReference type="HOGENOM" id="CLU_1493024_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1406-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="21000" checksum="E110D15A1E76A63E" modified="2012-11-28" version="1">MDPEKERTAEQIISHEVDAIASNSARIKENSCAACHVLFTLVGRMNLSETDAADLLTEVLLVKPELNDRFIEMVENVHMKQRMMGVTFAIKTREAKDRYIDSQFKNTLDELLADTANYGAGIVLRKLVMSYIALEMAQNIGIDYHAATEELYYYMRKRDEETHTALMKLVRSMIEKRSRYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN62</accession>
    <name>K0IN62_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c18870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18870"/>
    <dbReference type="EnsemblBacteria" id="AFU58819">
        <property type="protein sequence ID" value="AFU58819"/>
        <property type="gene ID" value="Ngar_c18870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18870"/>
    <dbReference type="HOGENOM" id="CLU_116765_4_2_2"/>
    <dbReference type="OMA" id="VAIFHTH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1885-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JAB_MPN" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14873" checksum="4BC1E27BB1500BF1" modified="2012-11-28" version="1">MEEIFLTSRQIDQLASLAKSSLPNESCAFLLGKNDRITEILPMQNADRSAISFSIKPQQVLQAYDLAESKKMQIIGIFHSHPAKPAPSSTDKRFMEINPVVWLIYSTTEHRFKAYVYDTDVREVVVKIITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN87</accession>
    <name>K0IN87_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58944">
        <property type="protein sequence ID" value="AFU58944"/>
        <property type="gene ID" value="Ngar_c20120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20120"/>
    <dbReference type="HOGENOM" id="CLU_201545_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2010-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7743" checksum="375BC4CAD61C10B7" modified="2012-11-28" version="1">MIKLNGENIAGTAFLFFSALLMAAGQVNAVFGKLYPAYYILVAAGVALVFLGYRTARNETMPPAKEHYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB2</accession>
    <name>K0INB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase FAD/NAD(P)-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c21390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21390"/>
    <dbReference type="EnsemblBacteria" id="AFU59069">
        <property type="protein sequence ID" value="AFU59069"/>
        <property type="gene ID" value="Ngar_c21390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21390"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2123"/>
    <dbReference type="HOGENOM" id="CLU_1006919_0_0_2"/>
    <dbReference type="OMA" id="PQEWFNR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2137-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="280" mass="31925" checksum="CE606BE1629F7DDD" modified="2012-11-28" version="1">MVVDNKAKISYIQIIKEDLGIFHITPENGPIPDFKAGQFVTLGLHVPSEGKIIRRAYSIASPPEQKKRFELYIRWVRKPVPGRLTTELFNKKEGDEILWVKPTGIFTINEKMHDGRPDNRRMVLIGGGTGLAPFVSYSLHLKAIGSKREIVVLHGASYVDELGYKDLLTSLEEESLDKGRDKWNFRYRASISRPQEWFNRTWNGQKGRVESFLRPKAGKDLSPLEELVGEKVTPENTSFYICGWQGTVDGALDYLIPKGFVTERNKRKDGSYDVKFESYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND4</accession>
    <name>K0IND4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59179">
        <property type="protein sequence ID" value="AFU59179"/>
        <property type="gene ID" value="Ngar_c22490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22490"/>
    <dbReference type="HOGENOM" id="CLU_2695895_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2247-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8711" checksum="F03B95473CFDC758" modified="2012-11-28" version="1">MGVHKKERGRDIGYWICQFCTGLAQEIGKRIACRYIVLQTIKIKSAYYEHKCMFHQTKKANPEGKIWMYRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND7</accession>
    <name>K0IND7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpl37ae</name>
        <name evidence="9" type="synonym">rpl37e</name>
        <name evidence="10" type="ordered locus">Ngar_c22640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22640"/>
    <dbReference type="EnsemblBacteria" id="AFU59194">
        <property type="protein sequence ID" value="AFU59194"/>
        <property type="gene ID" value="Ngar_c22640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22640"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2242"/>
    <dbReference type="HOGENOM" id="CLU_208825_0_0_2"/>
    <dbReference type="OMA" id="RIRRYSW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6759" checksum="2DD1D34945E6BDCF" modified="2012-11-28" version="1">MTKGTTSMGKFTRKKTHIRCRRCGHNSYHKRGKRCAKCGYPDPRMRKYDWIKRQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE7</accession>
    <name>K0INE7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59244">
        <property type="protein sequence ID" value="AFU59244"/>
        <property type="gene ID" value="Ngar_c23180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23180"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2316-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11615" checksum="A5D95FFCA366A384" modified="2012-11-28" version="1">MPLNAAGWSNRGWLEIIEFILLMCENGARKTHVMYRCNLNSKQINQYLEFLLDSGMLEMIQERPSSKRYIYKTTDLGKKFIAHYKQLASLFTKAPPPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI4</accession>
    <name>K0INI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59429">
        <property type="protein sequence ID" value="AFU59429"/>
        <property type="gene ID" value="Ngar_c25060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25060"/>
    <dbReference type="HOGENOM" id="CLU_2243948_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2505-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11484" checksum="D32B1CD6EC916699" modified="2012-11-28" version="1">MQNSRLLEDLILKATPPVMMIAAATLPARSKGNAGLRSKGKSEKLLQPLFLGQKRILPSIQTSQDKAGNRYPSSKDSNFASMFQAESSLASKAWFQFYFCKEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ4</accession>
    <name>K0INQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28600"/>
    <dbReference type="EnsemblBacteria" id="AFU59779">
        <property type="protein sequence ID" value="AFU59779"/>
        <property type="gene ID" value="Ngar_c28600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28600"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OMA" id="KEVRGTY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2860-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8972" checksum="30EFC0E68DA49719" modified="2012-11-28" version="1">MPTAYILVNCTLGSEEKIINEIAKLTDVKEVRGTYGVHDIFVKVKSENTEAMNHTITNKIRKVPGITSTVTLVVIEEQGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS3</accession>
    <name>K0INS3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59874">
        <property type="protein sequence ID" value="AFU59874"/>
        <property type="gene ID" value="Ngar_c29560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29560"/>
    <dbReference type="HOGENOM" id="CLU_153621_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2956-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="14261" checksum="D66AA1E45627C212" modified="2012-11-28" version="1">MVKRGGKEVVTVEIFKETYDVMKANAEKKRWNTKDYINMVLMEVIERDRFLQSYAPSLSKIGYEHNILFIRDAKKSKTAEIYLRDRALYCNVCDSKDCVHIHYALALPETAKLFLRKPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS5</accession>
    <name>K0INS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29660"/>
    <dbReference type="EnsemblBacteria" id="AFU59884">
        <property type="protein sequence ID" value="AFU59884"/>
        <property type="gene ID" value="Ngar_c29660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29660"/>
    <dbReference type="HOGENOM" id="CLU_2581540_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2966-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8962" checksum="93B75F05D81007EE" modified="2012-11-28" version="1">MGNAQMFRLDFPGGPLTMFICGNDKCAKKSVTEILDMFGWETVDIGGIEGSRLLEPLAMLWITYFFKTGIGNQAFKLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU6</accession>
    <name>K0INU6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="4">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">ImGP synthase subunit HisF</fullName>
            <shortName evidence="4">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hisF</name>
        <name evidence="6" type="ordered locus">Ngar_c30730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30730"/>
    <dbReference type="EnsemblBacteria" id="AFU59989">
        <property type="protein sequence ID" value="AFU59989"/>
        <property type="gene ID" value="Ngar_c30730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30730"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3045"/>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_2"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="268" mass="29193" checksum="CA6923BF807D981A" modified="2012-11-28" version="1">MTLAKRIIPCLDVDNGRVVKGVHFTEVKDAGDPVELAKKYSEQGADELVFLDITASQQGRDTMKGVVRNVASVIDIPFTVGGGIKKLEDARDILLSGADKVSINTAAVKNPELITQLMSIFGKQCIVVAIDAKRNYSVEKGKTIFKERGNKKFWFEVRIYGGKEGTGLDAIEWAKEVERRGAGEILLTSIDADGTENGYDIALTKAICKSVRVPVIASGGCGSARHMLDVFDKADVDAALAASIFHYKKSTVDKVKKYLKRSGVRIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY2</accession>
    <name>K0INY2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60169">
        <property type="protein sequence ID" value="AFU60169"/>
        <property type="gene ID" value="Ngar_c32540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32540"/>
    <dbReference type="HOGENOM" id="CLU_2079495_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3254-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12956" checksum="8C824F5DE819BEEF" modified="2012-11-28" version="1">MLKTSFRPYPPLQEDFNTSIIRIESSQMRELGINSGDIVRGVRSTGVICMLIEDGYKQPSDSTITYLHELGIILPQARISNIVALNTNNKGASMVEIEKVAQSTPAQRVIFTTSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP34</accession>
    <name>K0IP34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35160"/>
    <dbReference type="EnsemblBacteria" id="AFU60429">
        <property type="protein sequence ID" value="AFU60429"/>
        <property type="gene ID" value="Ngar_c35160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35160"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3519"/>
    <dbReference type="HOGENOM" id="CLU_030742_5_1_2"/>
    <dbReference type="OMA" id="YKPAFMY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3517-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="399" mass="44052" checksum="C147C5DC7C45E7C4" modified="2012-11-28" version="1">MTKKFLHSIPIFSLMGKRILILGAGFGGLAAATELRKNLSLDHRVIIVDRKKSFMMGLVKLWVLEGSRNLQESLTPLDGLNAKRIEYLNDEVTKIEIAQSRVQARDHGWIEYDYLIVALGAELAPDRIAGFVGRGYNLYDAQQVPKLRDRLLQLERGKVAIAIMGMPYKCPPAPYEASLIIDSMLSRQGTRNNIEIDIYAPAPIAMPVAGPQVSANVVEIISQRGISFHSSHKLKSVTDDTLEFENGSKADYDVLVGIPPHRVPEVVRSAGLIAAEGNSNWVAIDRNTMKTRFKNVFAVGDVTEIKVGAMALPKAGIFAEEQAKVAARQIIDEISGRPAVAAFAGQGYCFMEMGNGRAGYLEADFFNPAGPAVRLEAPSEQNFQKKQDFERIRVKEWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7B9</accession>
    <name>K0I7B9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57156">
        <property type="protein sequence ID" value="AFU57156"/>
        <property type="gene ID" value="Ngar_c02080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02080"/>
    <dbReference type="HOGENOM" id="CLU_2748313_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-208-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7841" checksum="E54D861A67DD691F" modified="2012-11-28" version="1">MTMKENLIDWQVSTTTAATLNALYVVDNGAPLSNDDACYYHNHQELVSTTTISRPSSFKKMKGEESRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7Z7</accession>
    <name>K0I7Z7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57396">
        <property type="protein sequence ID" value="AFU57396"/>
        <property type="gene ID" value="Ngar_c04500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04500"/>
    <dbReference type="HOGENOM" id="CLU_3194331_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-449-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5366" checksum="F7CBB3B1AD8D54F2" modified="2012-11-28" version="1">MLPRKTIYGRCPKCKTKSELEVISGTPGREKFRCNQCYHNFGMDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0I822</accession>
    <name>K0I822_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57421">
        <property type="protein sequence ID" value="AFU57421"/>
        <property type="gene ID" value="Ngar_c04770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04770"/>
    <dbReference type="HOGENOM" id="CLU_2044482_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-475-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="14018" checksum="D89DA997D5157DC2" modified="2012-11-28" version="1">MAWVLLAIKLKTSTCLAQTSTLRCFYEEPERAREIEFRFLRNGLFRGEHCIYILHEGDEIDIIENEIADNGIDVIHFKKKGLLHIVKVNDLLTRPEVYMDAFQNLLNDIANKFKPIVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I844</accession>
    <name>K0I844_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57441">
        <property type="protein sequence ID" value="AFU57441"/>
        <property type="gene ID" value="Ngar_c04970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04970"/>
    <dbReference type="HOGENOM" id="CLU_122701_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-495-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="147" mass="16161" checksum="235301D58E7B6E18" modified="2012-11-28" version="1">MLLKVIAIAALVVAIAVAVIVFAMPRQANTGAPNVRFTEFTPDRIDIRVGEATKIVFNVQNLESRAITDARVVTVIEPSSYQPYLSIDRPTVDLPDLQSKDARTGQMQVMITAASAPAREAVYTVKGVLFVEGTQSDVREFELRIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8G0</accession>
    <name>K0I8G0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ureG</name>
        <name evidence="6" type="ordered locus">Ngar_c06180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06180"/>
    <dbReference type="EnsemblBacteria" id="AFU57561">
        <property type="protein sequence ID" value="AFU57561"/>
        <property type="gene ID" value="Ngar_c06180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.594"/>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_2"/>
    <dbReference type="OMA" id="VDLTIYV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="218" mass="23712" checksum="A8F73F6A7C8F7AAA" modified="2012-11-28" version="1">MSKTRIPRVGVGGPVGSGKTMLIEKVVPVLSARGYKVGIISNDVVSKEDADRMRRNLAQEQHLMPEDLVIGLATGGCPHTAVREDPSMNLSVVEEMELKHGYLDMIMIESGGDNITTTFSPALADYFIYIIDVSGGDKYPRKRGLGIETCDLLVINKIDLAPLVGADLSVMDRDAKIVRGSKPHVFVNCKTGEGISKVAEHLIRDVLFESPPKAIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8M3</accession>
    <name>K0I8M3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR repeat-containing glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06880"/>
    <dbReference type="EnsemblBacteria" id="AFU57631">
        <property type="protein sequence ID" value="AFU57631"/>
        <property type="gene ID" value="Ngar_c06880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06880"/>
    <dbReference type="HOGENOM" id="CLU_070024_2_0_2"/>
    <dbReference type="OMA" id="HFYASGH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-686-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="325" mass="34342" checksum="A8B47E00C27C0C8E" modified="2012-11-28" version="1">MGKHEKKKSSPTVKSSKSGKTKFIAIGVGIAIVVAIGIGLAISMGNNVPSDSSNSRTVPWIHVHGLGIDPSDASVLYIATHGDFYKSVDGGVPVKVDKQRADYMAFNAPLTEGVPLYSSGHPSTGGNTGLIKSTDGGQTWQVVSTVLDPPVDFHAMSVSASDPDTIIGFDSGERGLFKTTDAGSTWDKFDYPGKYVIALAIAPDDPNVIFAGTPSGLFQSNDSAESWTQLDQYKGIAVMALTFDAEGNLYASTEEFGLAKSSDLGKSWENINRPPDNLIATSIAVDSENKLLYVAGHSASQGYQEVFRGSLDGSDWQLVGTNKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I936</accession>
    <name>K0I936_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57821">
        <property type="protein sequence ID" value="AFU57821"/>
        <property type="gene ID" value="Ngar_c08790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08790"/>
    <dbReference type="HOGENOM" id="CLU_2629846_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-877-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8439" checksum="DDA44EE9FF579E74" modified="2012-11-28" version="1">MAQMVAQGLSFQNVKDAIRMKAILDENKVDLVDIAALVGEARNAGVKLQAVVSDYKQMKACQLRERLLTLLHSANPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9B8</accession>
    <name>K0I9B8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57931">
        <property type="protein sequence ID" value="AFU57931"/>
        <property type="gene ID" value="Ngar_c09890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09890"/>
    <dbReference type="HOGENOM" id="CLU_3245476_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-987-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="42" mass="4592" checksum="04276844B473DC39" modified="2012-11-28" version="1">MRILELDESIIFAGILVTADGSLLAAEYRKGLTNPLLTQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9I2</accession>
    <name>K0I9I2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10640"/>
    <dbReference type="EnsemblBacteria" id="AFU58006">
        <property type="protein sequence ID" value="AFU58006"/>
        <property type="gene ID" value="Ngar_c10640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10640"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1062-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="15261" checksum="7B30ED1E838C1B59" modified="2012-11-28" version="1">MTSGGRHQNSPPRIMIVDDEKDILAILKSGLETKGNFAAETFNSGEAALQAFASHAPDYYDLILTDIRMPGMNGFELYRRIREKHPSIPIAFITAFEINEDEFSKVMPSIKVKDFIKKPIRIPELIEKLNAILAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9W2</accession>
    <name>K0I9W2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenical resistance-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58121">
        <property type="protein sequence ID" value="AFU58121"/>
        <property type="gene ID" value="Ngar_c11810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11810"/>
    <dbReference type="HOGENOM" id="CLU_077102_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1179-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="36288" checksum="318476897F508ACC" modified="2012-11-28" version="1">MLLTFYAVELLRNGKLSAALTKLKGEDIVLFIAIAASMATGVLLPSFGIIFEPYLLIWLGLLLFLNLIRLNLQDLASTFKKPVQLVILSMVKLVALPLTMYFIAKLVYEPLAVPVLLLSGISTGLGAPFVINAVEKSKKLPLVVGMVIVTSLGVPFALPSIVYLLLGGNSEFEIPIFNMVFLLSVALFIPIIAGWFAKKKWSSIAQRVDKKSFPVSIVLISLMNLGVFANFSSFFFKDLSFVFVNIAAAFALFAAYAAIGYVAGNIKYQGKIITMERSRDLGISGLIVMTYVNNILVVVFASQFFSIDVAALAAFYNLPYYGLILLLKIIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAQ0</accession>
    <name>K0IAQ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">leuC1</name>
        <name evidence="15" type="ordered locus">Ngar_c14750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14750"/>
    <dbReference type="EnsemblBacteria" id="AFU58411">
        <property type="protein sequence ID" value="AFU58411"/>
        <property type="gene ID" value="Ngar_c14750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14750"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1441"/>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_2"/>
    <dbReference type="OMA" id="VGYVYEY"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFU58411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="471" mass="51609" checksum="59654B870E6940AE" modified="2012-11-28" version="1">MPKTIFEKIWDSHIIYEKEGGGLSLLYIDRHLVHEVTSPQAFDGLRMNNRRVRRPDLTFATMDHNVPTSDRSLPIVDQISSIQIQTLAQNCKEFGITLFDMHSPDQGIVHVIGPDLGLTLPGTTIVCGDSHTSTHGAFGAFALGIGTSEVEHVLATQTLWMDKPKTFAINLEGRRRNPHAVTAKDMILYVIRTIGTAGGTGTVLEYRGEAMSELSMENRMTICNMSIEAGARAGLIAPDRTTFDFIRGRRYAPKGEQFEKAVEYWSCLRTDPNAKFDKSISFDVGSLAPQVSWGTNPGMVVDVTGAVPHPDEFAKGNENERKAAVRALEYMALEPGTPMTDVRLDRVFIGSCTNSRLEDLLEASMVVKGRKVSPNVRAMVVPGSQHVKAAAEQMGLDKVFKEAGFEWRESGCSMCLGMNPDILGPGERCASTSNRNFEGRQGAGGRTHLVSPVMAAAAAIEGHFVDVREWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB30</accession>
    <name>K0IB30_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58541">
        <property type="protein sequence ID" value="AFU58541"/>
        <property type="gene ID" value="Ngar_c16080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16080"/>
    <dbReference type="HOGENOM" id="CLU_159725_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1606-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9301" checksum="F0F566F27E292EFE" modified="2012-11-28" version="1">MFYEILCAIEEDAMHNEVARPTHVQHFTRLSYDKMMNHFDELEEKGMIHRVSGLVAITAKGRMFIEQYDQLISLIESAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBI8</accession>
    <name>K0IBI8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58641">
        <property type="protein sequence ID" value="AFU58641"/>
        <property type="gene ID" value="Ngar_c17080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17080"/>
    <dbReference type="HOGENOM" id="CLU_1922866_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1706-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="15351" checksum="D3435D0AFCE77F10" modified="2012-11-28" version="1">MYSNFVKKLEKLNPDIFDPDWIDRTLEPEEALLDLKRKHPELDIGLKEKEQIEGFREFLDEIGITNERLQNMIAMEDSPLSEDELNQLAYILQMRSEHAQKTDMALKAPLAKDVRTWIANPNRVDIKTVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBN4</accession>
    <name>K0IBN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nickel-responsive regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c00300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00300"/>
    <dbReference type="EnsemblBacteria" id="AFU56980">
        <property type="protein sequence ID" value="AFU56980"/>
        <property type="gene ID" value="Ngar_c00300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00300"/>
    <dbReference type="HOGENOM" id="CLU_113319_0_1_2"/>
    <dbReference type="OMA" id="YCMELFV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-30-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="5">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="6">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU56980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14346" checksum="62B54D07A420B6BC" modified="2012-11-28" version="1">MTIVSVSLNDDILAEIDKLQKTLGFSGRSEIVRAGIRNLLADEKDRQNLSGHLFAVLLAIHDEKSDDQVTEMGHGYDKLITTHIHNKIDGDRCLEIFLLKGDAEEIKDMTKKFQSNKKMDHVKLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC19</accession>
    <name>K0IC19_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58891">
        <property type="protein sequence ID" value="AFU58891"/>
        <property type="gene ID" value="Ngar_c19590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19590"/>
    <dbReference type="HOGENOM" id="CLU_147141_0_0_2"/>
    <dbReference type="OMA" id="DWERKQT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1957-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="11883" checksum="13788E4BF6EC8CF2" modified="2012-11-28" version="1">MAPDERLAQFLKNGKDWERKATSVPGVFLIKLPQFKGRAPSLAIEVNPVDASGAATKKRGIVIRSAPELEEITKLLINPKLEQLAHSIDEVNPERKPAVKAGEDVFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICB9</accession>
    <name>K0ICB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59026">
        <property type="protein sequence ID" value="AFU59026"/>
        <property type="gene ID" value="Ngar_c20950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20950"/>
    <dbReference type="HOGENOM" id="CLU_2392995_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2093-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10680" checksum="F0163F754F1692D1" modified="2012-11-28" version="1">MATTLMVDLSPYLASASRIFLAPNTSDQELVDRAKKRLAENGIQQDRIEINYDMQMLGTGDLYISYDPPDLVVRVVYEKKPSGIVKMKSAAMIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICK7</accession>
    <name>K0ICK7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57350">
        <property type="protein sequence ID" value="AFU57350"/>
        <property type="gene ID" value="Ngar_c04030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04030"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-402-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="17969" checksum="A41AB6FD78C9093C" modified="2012-11-28" version="1">MLQHMASRYPETGTITKVGEIMTERLETINFLNTAQEAALKMADKNVSSLAVIDDDGKAAGIVTERDLVRRVCTKNTHSSMITIQNIISVPVKTVSPDTAIDEAADIMVRNKLRHLIVADENNAPIGIVSATDIVGFIRENNVAKTQVSKEILEALEREGRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICS1</accession>
    <name>K0ICS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57445">
        <property type="protein sequence ID" value="AFU57445"/>
        <property type="gene ID" value="Ngar_c05010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05010"/>
    <dbReference type="HOGENOM" id="CLU_1840643_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-499-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15491" checksum="E8C7174017DBB047" modified="2012-11-28" version="1">MTTEEQKKPSDAELRTIGGSSRFIETHPKVVPTDFGSVFAEKIMIGVDEVQGIVTMTFLQRNLHPQIGSNGWQISDVNWKVIAEVKTPMVEMNALMIYYIAVVTGGMDVLPVIQQYLKQHPKAPSEGKISYGPTRIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID44</accession>
    <name>K0ID44_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pfdB</name>
        <name evidence="9" type="ordered locus">Ngar_c23810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23810"/>
    <dbReference type="EnsemblBacteria" id="AFU59306">
        <property type="protein sequence ID" value="AFU59306"/>
        <property type="gene ID" value="Ngar_c23810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23810"/>
    <dbReference type="HOGENOM" id="CLU_131909_1_0_2"/>
    <dbReference type="OMA" id="PPQVQAM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15006" checksum="C170265B532F7B77" modified="2012-11-28" version="1">MSEQELPPWLREQVSRLQQLQQNLQAIMMQKQQLEVETVETDRALEELKKAGPDDAVYKNAGSVLVKAKKEDVIKELEEKKELSNTRVMVLGKQEARVKENLKEVENKINEMIRGMQGGAPGPSAGAGPKPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID68</accession>
    <name>K0ID68_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ilvA</name>
        <name evidence="5" type="ordered locus">Ngar_c24060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24060"/>
    <dbReference type="EnsemblBacteria" id="AFU59331">
        <property type="protein sequence ID" value="AFU59331"/>
        <property type="gene ID" value="Ngar_c24060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2379"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_2"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="343"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="418" mass="44921" checksum="A2B7C69CF7CA67F6" modified="2012-11-28" version="1">MNNDSVWDPDKRQKMPKIEDILKARDLLSETIRKTPLQSTRTFSGLAGTNLFMKLECLQVTGSFKVRGAFAKVSRLSDKQAGYGVIAASAGNHAQGVAYAAAIKKIPCTIVMPQNASPAKVAATRSYGAQVVRRGANYDEAWEATQEIARTEGRTIIHAFDDPDIIAGQGTIGLEILEDLQDVDRIYLPVGGGGLAAGVAIAVKSKKPNVKIIGVESKAFPAMKESVAKGSLQSTKRGYSIADGIAVKQPGKLTYEIVSKYVDDIVLVDDVSIVKTMFLLMERAKLVVEPAGAASLAYLISNGGHAGGRKDKVVTVLSGGNVDMYLLGQVVAKGLMQMGRMLKIFILLPDKPGALKGVVDSIAELSINIVEVEHDRLSSHIPAGTAGVYLSLEMEDEKHAQRLVEFLKQKEIEFKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDQ4</accession>
    <name>K0IDQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59526">
        <property type="protein sequence ID" value="AFU59526"/>
        <property type="gene ID" value="Ngar_c26040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26040"/>
    <dbReference type="HOGENOM" id="CLU_2893370_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2604-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="7376" checksum="C1AF6289990A7E19" modified="2012-11-28" version="1">MALPTHSLGYWDSYDDKLAMIIEEPYSQLFLTIVVVYLIWLRTIIYARNHHDHKKKKNASIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDX7</accession>
    <name>K0IDX7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheA</name>
        <name evidence="7" type="ordered locus">Ngar_c10180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10180"/>
    <dbReference type="EnsemblBacteria" id="AFU57960">
        <property type="protein sequence ID" value="AFU57960"/>
        <property type="gene ID" value="Ngar_c10180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.969"/>
    <dbReference type="HOGENOM" id="CLU_000650_3_7_2"/>
    <dbReference type="OMA" id="NELVECC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="232"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="5">
        <location>
            <begin position="438"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="574" mass="64165" checksum="F6640B2E84F66439" modified="2012-11-28" version="1">MARWKVKERGKECSSMSDDFSKYREMFVQEAIEHIQSLNNAMLQLEQDPHSKEHLDSAFRAAHTLKGMAATMGYEQIRQVCKTIEELFDRLRKREVRLTTGVADFLFKSFDVLDKMVNDENKIINMEEFMQEFQKVTSGSENASGQQGYDLSSPNASAAAANGMIIPAAEQSGISEETGNNQSHTKTQTIRVKMDDLDSLVDLVGEIMIAKMRLEQVLSDSQQAGKPRQVLRNLDRLINNLQNHTMKIRLVPIEQIFDRFPRMVRDLSNSQGKEVRLEMEGTGIELDRTVLDAIRDPLLHMLRNSVDHGIELPEEREKMGKPRHGTIKLKASRLGDKVLIEVSDDGRGIDLEKVKEKAIEKHIINRQEAEAMTTEDIVDLLGSPGLSTAQKVTDVSGRGVGLNVVINKIESVGGTVRIKTEKNHGTTFTMTIPLSLAIIGGLLVKIGNEKYVIQISNVLSTIQIDQDELRRIHGKPVVMFREQVVPLVYGAEVLNVPQTPAQDSHCKMTVIIVEKGGKPLGLVVDSFESKQDIVLKHIDRIGYNSSNVPTDATILSDGRVALILDLTQLEEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDY2</accession>
    <name>K0IDY2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c10230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10230"/>
    <dbReference type="EnsemblBacteria" id="AFU57965">
        <property type="protein sequence ID" value="AFU57965"/>
        <property type="gene ID" value="Ngar_c10230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.974"/>
    <dbReference type="HOGENOM" id="CLU_047366_0_0_2"/>
    <dbReference type="OMA" id="TRGYNAY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1021-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="8">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="396" mass="44087" checksum="BD1D1EDE5B3F0A8D" modified="2012-11-28" version="1">MVPVARQTIMVGQCTDFTLLACKEGSKAMTLQQNTNEQEEIKSSFSLEKVAELTEILAQKTEAAINQIDRINGETQVLSINALIEASRAGEVGKTFSVVAEEMSKLSKKIEDTTEHLRRESMSTMAEMGEIIKKQITSIRGIRLSDLALVNIDLIDRSLYERSCDVRWWAKDSSLTSALADKNNKDAIAFASKRLGVILDSYTVYFDLVLCDSAGNVIANGRPNQYASLGKNQSETAWFKSALEATKDGFGFQTVHRCPLVNNQLTVIFSCSVHDQTEEDRVIGVLGVIFNWEALAQKIIEDTPLNEEERANSRICIIDSDGLILADSRRKMLESRIQFSGMETLLAEKKGFVITTYENGECCIAHAFSPGYETYASGWHSLIIQKLPKKSDSKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE56</accession>
    <name>K0IE56_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enolase</fullName>
            <ecNumber evidence="5">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">eno</name>
        <name evidence="10" type="ordered locus">Ngar_c11180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell surface</location>
        </subcellularLocation>
        <text evidence="5">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11180"/>
    <dbReference type="EnsemblBacteria" id="AFU58060">
        <property type="protein sequence ID" value="AFU58060"/>
        <property type="gene ID" value="Ngar_c11180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1060"/>
    <dbReference type="HOGENOM" id="CLU_031223_0_1_2"/>
    <dbReference type="OMA" id="QHLGGAF"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 5 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="8">
        <location>
            <begin position="130"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 7">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="412" mass="44686" checksum="ED0C0FD168075D45" modified="2012-11-28" version="1">MPSITAVRGRIVFNSRGSKTIEIDVVTDNKFIGRACAPSGASVGRLEAQSFPENKPEKALAAFNTNAKKFIGLQAENPQAVFDTLRSIDKTDNYSTIGGSVAYALSIAAVDSAARALNVPLFKLLKPAKPYKFPFPLGNILGGGAHAGPGTPDIQEILACPVGAKGIVEALEMNFKVHAETRKVIESIDRRFTYGRGDEGAWAPNVNNDQALEIVEKAVRNCGYTLGKDMAIGIDFASSSFWDEKNNVYNYARQGIKRDTGEQIEFASRLVRDYKLVYAEDPVHEGDFESMAVLTKKNQKTLVTGDDMLVTNAGKVREAVRYGACSGAILKVNQAGSLYDAIKFAEECSKNNIRIITSHRSGESVDSHISHIAIATGSRMIKTGVLGGERVAKLNELVRLTEYDLIEGMNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE89</accession>
    <name>K0IE89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoD1</name>
        <name evidence="7" type="ordered locus">Ngar_c11540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11540"/>
    <dbReference type="EnsemblBacteria" id="AFU58095">
        <property type="protein sequence ID" value="AFU58095"/>
        <property type="gene ID" value="Ngar_c11540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11540"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1094"/>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_2"/>
    <dbReference type="OMA" id="IMGTSME"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="141"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="312"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="386" mass="44332" checksum="1E70331EE19DABB3" modified="2012-11-28" version="1">MTSLEDKFEESKRLGLQIVKESEEDRLMTLSIGPQHPGSGHFRFTVKVDGDYIIYCDPDPGYVHRGEEKMCEYRNVIQNIPHLERPVIHDSTNITYAYSLAVEELVGIEVPRRGQYIRAIASELNRQVYTLYWLAIYGIFLGHSTMFMWPTGDRELFIDLLEALTGARVTHAFNIPGGVRNDMPDGFKDRCLRQVRYFQKRLKEYEDIFYNMPLFRQRTEGVAVLSKEDAAKLGVTGSVLRASGVPYDIRKAEPYDIYNEIDFKVQYMKTGDCFARSYVPFLDMQESCHIIEQLLDKMPQSGEVRAKLQPNPKGPPGEAYRRVESGRGALGYYVVSDGTPKPYRVKISVGSFRNMLALPYLLVGQRLADMPAVYWSLNYWPVEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IED2</accession>
    <name>K0IED2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11950"/>
    <dbReference type="EnsemblBacteria" id="AFU58135">
        <property type="protein sequence ID" value="AFU58135"/>
        <property type="gene ID" value="Ngar_c11950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11950"/>
    <dbReference type="HOGENOM" id="CLU_075000_0_0_2"/>
    <dbReference type="OMA" id="MPVRIYE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1193-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="265" mass="28695" checksum="786188E510D5F0A6" modified="2012-11-28" version="1">MMMAGRDNERTAIRPVERNQKIRLNDAILIAGFPGPGIVGAMSASYMIEQQKMHQIAYVDSDFITPGVMYIGGRLRHPFRIYANNEGTACILVCDAPVILSGIRPLLNAVVRWAKDNDVREIMVLEGIATLNLPEAARKPLVMTSDGRSDDHGYLSHIKGKAEAAPPAFIAGISGGLLAACLSNGIPCTGLLISSIAGIPDPEGAAILIEKANELANNPFKIDVRELRTEAAELKRQMQELINSVQRQQRQQENQQIGGGPGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEK7</accession>
    <name>K0IEK7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59786">
        <property type="protein sequence ID" value="AFU59786"/>
        <property type="gene ID" value="Ngar_c28670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28670"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2867-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10190" checksum="CA7CB522CC6FCADC" modified="2012-11-28" version="1">MGKYRSRTEIVCQILVTAREIDGVAKTKIMYKAYLSFTQLREYLKLLMDSGLLEHIPERNTYRTTDKGIKMLETCNTMNQLVGREAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEW2</accession>
    <name>K0IEW2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="1">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">top6B</name>
        <name evidence="4" type="ordered locus">Ngar_c29780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOP6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29780"/>
    <dbReference type="EnsemblBacteria" id="AFU59896">
        <property type="protein sequence ID" value="AFU59896"/>
        <property type="gene ID" value="Ngar_c29780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2951"/>
    <dbReference type="HOGENOM" id="CLU_006403_0_0_2"/>
    <dbReference type="OMA" id="TRIELEM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="43"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="681" mass="76100" checksum="2F6936AAAE454C7B" modified="2012-11-28" version="1">MKQKATVEVAAAQQKPLTKGKVRYDKKAESEFFVDNSALAGFTTERILYMAVRELIENSLDSCETGHILPKISLSLKMSDQANDLWTITCEDNGIGVPLDKVPVAVCSFLTSGKYVEKQQRGLFGVGLKMIAAFSTKDTIHPLKVWSKSHEEGSEYYFELRTDISTNKPIVLAKRPAKGEESRIVGDSGFRVEAVLHAKLSPITRNNIKAKINEYISQTSIVNPYAIIEYETDEGKVTFDRRTEVMPQPAKEVLPHPADMDLQTLKKAIMNFMNNKTTLQGVLAASFQKMSSEKAKDIIAKAGLENKPADKYSENELIEIVKVCKHMPFQQANTDHLSPIGEEILTTGMTSEYTIVTTKEVVPAAEGSGAPEVQKPQITVKVLKPSLTAYASRTCVINNRPTIVECGIAYGGDIPSFKLYRFANKIPLLYDEGSDVAREVVSEVEINKMGITKKEAKEQFANPEVKSDRAVELLPLHIFFHICSTKIPYKTAGKESIASEGELKKYMKYCLSELYRKVSAQIRKELRMKEAQSRLNLYKYYIPLIVSAISESIKVDPVKLEQAFTELAEKHVRIEQLVNNTPSSTTTAEKEDKITTERIEEEAEEAVEIDGELIKPDKDQIAINTARKKGKLSKPKARKEKVPETLQKDDDKQATLDTVIKDNNKPLKGGEVRRKKANASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF18</accession>
    <name>K0IF18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58370">
        <property type="protein sequence ID" value="AFU58370"/>
        <property type="gene ID" value="Ngar_c14340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14340"/>
    <dbReference type="HOGENOM" id="CLU_1648359_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1432-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="17670" checksum="184CBF0714598C0C" modified="2012-11-28" version="1">MVKTRGSYGHLKISCWINSEKLVILIGLLFQISLVLLAFHPIAADTQGQTKGTINHATNLSLTGTAIYPAVAASSNNVYVAWTDYFVGNDEILFRKSDDSSATFRNIINLSKNPGSSQRPQIVAAGNYAYVLWNDNTYDGTWNILFKSIRTKILLPSTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF39</accession>
    <name>K0IF39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c30600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59976">
        <property type="protein sequence ID" value="AFU59976"/>
        <property type="gene ID" value="Ngar_c30600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30600"/>
    <dbReference type="HOGENOM" id="CLU_2784242_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3060-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7634" checksum="3C990B3D92DF3A0D" modified="2012-11-28" version="1">MVDTTETISCPICDIPFDTRDELERHSRKTHATITTKEATPKGSTPAMEERVQSRTEEKGKGETPEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFE5</accession>
    <name>K0IFE5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57553">
        <property type="protein sequence ID" value="AFU57553"/>
        <property type="gene ID" value="Ngar_c06100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06100"/>
    <dbReference type="HOGENOM" id="CLU_1357954_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-608-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="23017" checksum="3EF68F50B9AFC447" modified="2012-11-28" version="1">MNPNTFEQFLSESRHAFRDKSDSEKIKFFTDWCKKNGTEEVILRLSSENKGGWSSNFYLDFTTARIIITKKSFFTKFADVGYVAGLAPYPYLLLLKNPDPSKIRKQASLAPDELVKSENYSDSIWYSEIKEIILRKGIETAVANMFGRAIVANFLAISASGGRRFDFKLPVNKNGTYEQVHFWVNVVLPPHCQLQNDIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFI4</accession>
    <name>K0IFI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32100"/>
    <dbReference type="EnsemblBacteria" id="AFU60126">
        <property type="protein sequence ID" value="AFU60126"/>
        <property type="gene ID" value="Ngar_c32100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32100"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3197"/>
    <dbReference type="HOGENOM" id="CLU_079096_0_0_2"/>
    <dbReference type="OMA" id="QTANEIM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3210-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20727" checksum="F6742430E35CFC29" modified="2012-11-28" version="1">MKLVITGNPGVGKHTSAKIIAGKIGAEVIDINRVAIDDNAIAKKTERGLEVDVKKLDGLLANLLKTRNDQIVVGHLAPYVLKPAAGISMVAVLRRSPYELEKTLEKRGYRAEKIKENLASEILGVSLYDSLKIFGRRKVVEFDTTGKTPDQTANEIMRALRKKPKPAGIDWLALVSERGDMQRFFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFP7</accession>
    <name>K0IFP7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58640">
        <property type="protein sequence ID" value="AFU58640"/>
        <property type="gene ID" value="Ngar_c17070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17070"/>
    <dbReference type="HOGENOM" id="CLU_1551872_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1705-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="19757" checksum="81660CADD08A23FB" modified="2012-11-28" version="1">MAKQASTAVSSGQKTQTAREDNGKSKSKEKLHWTKVTLDLTTEELEIYKQIADRFDTPLADYLVNEIRDSSRGLCEPEFVGAPFAHTSKSRLKAIIELAEKQKPDTDDIVTLSIKVNRKHWDRFMKLPEPVRQAYLERVVDDTVEEIFKDPKMLGYYMNEYTKEKGDLKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFS1</accession>
    <name>K0IFS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60221">
        <property type="protein sequence ID" value="AFU60221"/>
        <property type="gene ID" value="Ngar_c33060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33060"/>
    <dbReference type="HOGENOM" id="CLU_2379512_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3306-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10886" checksum="1963F6727CAC9127" modified="2012-11-28" version="1">MDGGLGFPDSVLSACYPKGSGQPNYDHARDFWFRFWDRKPETARAMMHGNGKPNSSEVVTLTRDYPAVIAYEILNEPEIWRKADYFKLLQCFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG53</accession>
    <name>K0IG53_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57793">
        <property type="protein sequence ID" value="AFU57793"/>
        <property type="gene ID" value="Ngar_c08510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08510"/>
    <dbReference type="HOGENOM" id="CLU_122242_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-849-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="19907" checksum="D0217C17C48134CA" modified="2012-11-28" version="1">MATRTGGRSKPEKNDFSPEQAAEAVKEAAKKIRETSQQVRDSVKTFKDSGAVTEMAEATRDAALAARDTTRDVRDTAREVRDTKVVAETASALDETANAAVETGGAAKDTVEQIPRSAPRTTKAVKRGAAEARKGAKTAARQTERAVKKGSAKMRRTAKRAVKRQVKSVKRKANQQKKKTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG90</accession>
    <name>K0IG90_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57838">
        <property type="protein sequence ID" value="AFU57838"/>
        <property type="gene ID" value="Ngar_c08960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08960"/>
    <dbReference type="HOGENOM" id="CLU_1113904_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-894-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="27499" checksum="A7D33E19C7535411" modified="2012-11-28" version="1">MIRYILRKYLAPLIGVVTIVVVFILIFQSTIREEHRTGKLYAPSGAFPASFDKVTEGSTIMNYRFSSVADHAILEPHGRNAIINGEYKLSNGFLKLVGNKSNISISDFPEINTENIAFSLNLKITNIGSRQALLVKGYHSELGYGQYGINIEPNGKLRLIVRSDNGNNLILYSNKTLTEGTAQVGFVITKSSAAIYIDGHLEKVGEIPSHLLTSNQKLVYKDLTVGNQPVALNEVFRGGIIKLTIFQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGG4</accession>
    <name>K0IGG4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ordered locus">Ngar_c09810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09810"/>
    <dbReference type="EnsemblBacteria" id="AFU57923">
        <property type="protein sequence ID" value="AFU57923"/>
        <property type="gene ID" value="Ngar_c09810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.934"/>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_2"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="300" mass="31593" checksum="25B887C20B6E43CB" modified="2012-11-28" version="1">MEKTNKKELRELMVRQSLKRKITDKVVSALAIACVVAAIIPLGSILIEVVKNGVSSLNVEFLTQTPGSLGSGEGGIGPAIQGTLIVVGLASLIGGPIGVLAGIYLSEYAGTSRFAYSVRFLNDVLTGLPSIVIGIVGYVAIVLTIGSFSVWAGAFALSIIMIPIVVRVTEETLKIVPNSIREAGHSLGIPKWKVTMFIVLSSAKSGVLTGVVLAISRIAGETAPLIMTILGTSLFFTGFTSPVDALPLRIWRLASQPYESAHSFGWGAALILILIVLGLSISLRLLAQKRGFRAHSTTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGJ9</accession>
    <name>K0IGJ9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">cheD</name>
        <name evidence="4" type="ordered locus">Ngar_c10160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10160"/>
    <dbReference type="EnsemblBacteria" id="AFU57958">
        <property type="protein sequence ID" value="AFU57958"/>
        <property type="gene ID" value="Ngar_c10160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10160"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.967"/>
    <dbReference type="HOGENOM" id="CLU_087854_2_0_2"/>
    <dbReference type="OMA" id="VGMADLN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="18593" checksum="3363D74E79913FC6" modified="2012-11-28" version="1">MEEASSWRRVAEIDVKMGSYSISNHQNSALTTFVGSCIALCMYEPAAKVGGLAHIMLPSSEGRYMPADGHEAKYADHALKVVVEGMKQKGARVDLLISKLIGGAKTFTNENSAADLFNIGERNYLSIKSLLTQYNIPVLAEDIGSTQGRWVKLDVSTGQVTVRNKTSEVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS9</accession>
    <name>K0IGS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21140"/>
    <dbReference type="EnsemblBacteria" id="AFU59045">
        <property type="protein sequence ID" value="AFU59045"/>
        <property type="gene ID" value="Ngar_c21140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2096"/>
    <dbReference type="HOGENOM" id="CLU_965066_0_0_2"/>
    <dbReference type="OMA" id="EGANECA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2112-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="325" mass="37241" checksum="9578BA62E0A38FBB" modified="2012-11-28" version="1">MKVQFAHHLVCLHHTDKQLRLNLESLAMEGANECAEGFLKCKECDATYPIIQGVAIVVKDFASYAAGRSQMYGKWLLDSKTKEMKEFLKKSGSKLSPSTAANDRYEEGGSWFVPYRWTQYDHSPEDRLLKSLRWRLKPNEVYNRVVHGINPKMDGVALDMACSMGYSTMLLAQKYAFAIGIDLSFSFIKEARKKMYEGKRGNIEFCVADSLNAPFNPGKFDLILALNLLELVDHDKLLASVHRLLKPHSDVIIADPYDYNRDPPAKKIYDGQSFRKLIENSGFEIGEKSSKTESFIPWVLKVNERAYLFYFVDYIKAKKISKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH08</accession>
    <name>K0IH08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59140">
        <property type="protein sequence ID" value="AFU59140"/>
        <property type="gene ID" value="Ngar_c22100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22100"/>
    <dbReference type="HOGENOM" id="CLU_2550073_0_0_2"/>
    <dbReference type="OMA" id="QNNESHT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2208-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9469" checksum="90AC2378405FAA4C" modified="2012-11-28" version="1">MATLSMNDKLILVQYAIDKYDSENVLKEKLKDTLSPKEIERAIDTLIGTQKVRRIGADVLQNNVSHTGELPELPDHLKPIIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH93</accession>
    <name>K0IH93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12950"/>
    <dbReference type="EnsemblBacteria" id="AFU58233">
        <property type="protein sequence ID" value="AFU58233"/>
        <property type="gene ID" value="Ngar_c12950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12950"/>
    <dbReference type="HOGENOM" id="CLU_152487_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1293-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8850" checksum="A4FB0FDD01198F1B" modified="2012-11-28" version="1">MRAEELANSIVRTVVTAMRDGNHNAFFAAFAPSAVLTDDGHPQSFVEWADSEIFQAHGRLDVEQENHNGLELVGPFHSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF5</accession>
    <name>K0IHF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57217">
        <property type="protein sequence ID" value="AFU57217"/>
        <property type="gene ID" value="Ngar_c02690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02690"/>
    <dbReference type="HOGENOM" id="CLU_2327140_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-269-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11043" checksum="17A26FF7D9B789FE" modified="2012-11-28" version="1">MGDEWSQWLDFDKANVEAVPESPGVCVMHARMKILYIGASPNIRQELMGRLSDPCTAKAKRFRYIVTPAFESVKEQQVKEYVGKHGKLPPCMEEQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHH3</accession>
    <name>K0IHH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59375">
        <property type="protein sequence ID" value="AFU59375"/>
        <property type="gene ID" value="Ngar_c24510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24510"/>
    <dbReference type="HOGENOM" id="CLU_1444715_0_0_2"/>
    <dbReference type="OMA" id="CCIEREY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2449-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="194" mass="21388" checksum="810507757970C2EA" modified="2012-11-28" version="1">MMIKKFSCVQGCSDCCIYREYYPSIEYGKIGVLLLPEEKTAIKKLAKKMSVQVKIIPRLAVGKEFPEKVIAYQMMGKNDDGDLCPFLDVESGERSPHGGFNCRIYPERPLACRAYPVIDAGSTATVATLDGHCQFCKKFSTTRAENSCLQQEVEALVRIKANVTAGKSKVWRYATATGRAGGDAMLPEGWVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS0</accession>
    <name>K0IHS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative heme-copper oxidase subunit II</fullName>
            <ecNumber evidence="7">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coxB</name>
        <name evidence="7" type="ordered locus">Ngar_c25630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25630"/>
    <dbReference type="EnsemblBacteria" id="AFU59485">
        <property type="protein sequence ID" value="AFU59485"/>
        <property type="gene ID" value="Ngar_c25630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2540"/>
    <dbReference type="HOGENOM" id="CLU_1623389_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="18270" checksum="722CFEDB30D87744" modified="2012-11-28" version="1">MGHATIEWVYVGVVIAILVYVGADAWNIERLLEHAPEDAETIKVTGAQWVWTFEYEDGTREIGKLHLVKGQPYRFEITSVDVIHSFNIPDFAIMMDAVPGRINTIWLVPDQSGEYLIQCREYCGLSHYQMRGTLIVEEPSGEEGEANITSAAVEAPSKGATAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS9</accession>
    <name>K0IHS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58503">
        <property type="protein sequence ID" value="AFU58503"/>
        <property type="gene ID" value="Ngar_c15700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15700"/>
    <dbReference type="HOGENOM" id="CLU_2299428_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1568-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="10813" checksum="D79D1D6E8F72AE0C" modified="2012-11-28" version="1">MMAEQQSVVQQIKSFKIGGLSHSETAVAFMSSAGAFVTYAYVLDRLPAWFGIYTNLVIGLGSLVFAALFRIQFLSPFLLGASSIFLVDGIIDVFAGRMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV4</accession>
    <name>K0IHV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57472">
        <property type="protein sequence ID" value="AFU57472"/>
        <property type="gene ID" value="Ngar_c05290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05290"/>
    <dbReference type="HOGENOM" id="CLU_2712958_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-527-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8255" checksum="F4343307E47A8F9B" modified="2012-11-28" version="1">MQLMKIIEDSYLNGRGIMSVDELISALGSFDSFTLRRQILTLEGKGLVKKSERGYMLTEKGKQKLQDFLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0II68</accession>
    <name>K0II68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59635">
        <property type="protein sequence ID" value="AFU59635"/>
        <property type="gene ID" value="Ngar_c27140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27140"/>
    <dbReference type="HOGENOM" id="CLU_2930315_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2714-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="7150" checksum="F9753F74B5E9BFE1" modified="2012-11-28" version="1">MWSIVAIIGFFLTVSNFVNKQSLFETGKRWHSRQGNHPQNNANHATAKNDVFWREKLYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID4</accession>
    <name>K0IID4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative snRNP Sm-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c18100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18100"/>
    <dbReference type="EnsemblBacteria" id="AFU58743">
        <property type="protein sequence ID" value="AFU58743"/>
        <property type="gene ID" value="Ngar_c18100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18100"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1788"/>
    <dbReference type="HOGENOM" id="CLU_1782541_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1808-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="PTHR11021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="76"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="16716" checksum="99A19BF2AE6DC839" modified="2012-11-28" version="1">MPVRMPPPPRSESIAFEPVEMVVANVPSSLYLYYVQNPLMNLRQRNLFIRATIFQKRLVRLSSSPSSQQQPKRPLSTLQRAINRKVAVRLKSEIEYKGRMNNVDSYMNLILTDAEEFNGSDVLANYGKVVIRGNNVLFIKLEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM0</accession>
    <name>K0IIM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59760">
        <property type="protein sequence ID" value="AFU59760"/>
        <property type="gene ID" value="Ngar_c28400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28400"/>
    <dbReference type="HOGENOM" id="CLU_2177964_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2840-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="11313" checksum="F3BB53B2A8D6C49C" modified="2012-11-28" version="1">MVPDSFGNSMTSDRRKKKLVTVVGVAAAAALLLGFVFATTATANTNNIAAYATTTAETTSTGKLTKADAARIVPPIEDPPFLVPFSQAAATVEKEFPIAKLQAVRGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR2</accession>
    <name>K0IIR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase, AAA-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29110"/>
    <dbReference type="EnsemblBacteria" id="AFU59830">
        <property type="protein sequence ID" value="AFU59830"/>
        <property type="gene ID" value="Ngar_c29110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29110"/>
    <dbReference type="HOGENOM" id="CLU_626454_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2911-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="297"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="437" mass="49462" checksum="66CE3CF4D02A3BD7" modified="2012-11-28" version="1">MYGSTSIIAKFVSDYIIGRRSEYGGAILKVCYINVQGIPRPLMAKLELSYKDDAAHERNESTNDYGDFVMCSYKLNMDSVLSMLSSIASENSFDPPDKRPKLSFTQNADCYLLNSKSQYAWGYHQWPCLYATFKIPEFQINASYQVLAKRGLPLYPDMYVGITEFLDLSSSIGHHSNMYQMIVVVPDFKARIDRLVISGKKVSLTVESKSAPLENLVAKIYLAKGRQSYQSEDLSLSSSVVSTEVDFEPDIVTACILDNRDDVLDLREHHLDWTQYNEDVIVEMPSNQIIELIQRGENEKIEFKQTAGEDFLEPVVSFANAEGGMILLGVDNYGKIVGYNEDVDKLRDKLASRIRSNIQPSNIKFSVQRVELEGQTLDDKKQVVIAITIYSGQSKPYYLRDKGILIRHGASDRAITPAELDEIYARRGNNNNRSPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU5</accession>
    <name>K0IIU5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20720"/>
    <dbReference type="EnsemblBacteria" id="AFU59003">
        <property type="protein sequence ID" value="AFU59003"/>
        <property type="gene ID" value="Ngar_c20720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20720"/>
    <dbReference type="HOGENOM" id="CLU_031397_3_1_2"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2070-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="22422" checksum="96CF93CB74244E71" modified="2012-11-28" version="1">MKKNRQKIVFKCTGDAVARCASVIKSGGVVVFPTDTIYGIGCDPYNDRAVKRIFAIKGRDEKKPLPVLAHSMSDAEKIVSLGKAGRTLAKKYWPGALTIVAPITDSRISRRVTAGSGSLAVRVPANKCVLSLLEQCKYLVGTSANPSGGRPLKSAQEVLESPLHGYDALMDGGLVERGIESTIVDVTGSSPKILREGAIRSSEVLEALGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ37</accession>
    <name>K0IJ37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SNF7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c21930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59123">
        <property type="protein sequence ID" value="AFU59123"/>
        <property type="gene ID" value="Ngar_c21930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21930"/>
    <dbReference type="HOGENOM" id="CLU_095961_0_0_2"/>
    <dbReference type="OMA" id="NREPIRY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2191-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="224" mass="24571" checksum="6B44202AD005AB60" modified="2012-11-28" version="1">MLVGMTSFSSNWVKDNKPNMSERIKQNIGPQQPLKPRIELAKNKIQAQNQKLETILEKLRSKEKSLFNQVVSALQRHDTQHGKMLSNEIAQVRKTIKMISQLKMALEQIQLRLESTIDLGDVMVAIGPAMGALTRVRSGLAGVMPEVDRELGEINGVFSDIMMSAGSMSNTSFAFDASGEEVDRILAEAGAVAEQRMTDSFPDVPIGSSSTRTGTTTTSENAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ77</accession>
    <name>K0IJ77_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60055">
        <property type="protein sequence ID" value="AFU60055"/>
        <property type="gene ID" value="Ngar_c31390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31390"/>
    <dbReference type="HOGENOM" id="CLU_1465150_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3139-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20227" checksum="D978DCF2F9F45CBB" modified="2012-11-28" version="1">MVNASLSNVSECLKFWKSLGMLEDQDGKSKPSQTLTAIVQKMEWGSDDDGWKLFRDAIGSSWFVSSLAVAFRLKKSLSEDEILNTLGLTSKLPDREKVEKPLKNLIQLLNISKILIPGDDGRYTLNPDIASRQSTGTNMVVDDSKQMAQVRIGGDTYVVEVEALRDFVKANGKTVDTNVNSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE1</accession>
    <name>K0IJE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14410"/>
    <dbReference type="EnsemblBacteria" id="AFU58377">
        <property type="protein sequence ID" value="AFU58377"/>
        <property type="gene ID" value="Ngar_c14410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14410"/>
    <dbReference type="HOGENOM" id="CLU_1559542_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1439-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="21226" checksum="5276389EBA671CD9" modified="2012-11-28" version="1">MIRYGVRLSSITIDADGSPSGYIAWYNHSTGEPGIKILRPPARNEKYGVQRMEMLAIYFAIVKNQRQISMLASSQKRKQIVVNIRSDSKTCIEQLQGISKVRDAVLQRICTSIRKLLDRMPYMIIFNYLERARNHAGLLLERRRRKEIEEDLMHRYQKQYYYSSASGFMMMNHYYSGSLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG8</accession>
    <name>K0IJG8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23830"/>
    <dbReference type="EnsemblBacteria" id="AFU59308">
        <property type="protein sequence ID" value="AFU59308"/>
        <property type="gene ID" value="Ngar_c23830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23830"/>
    <dbReference type="HOGENOM" id="CLU_2550391_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2381-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9222" checksum="668225541BA81172" modified="2012-11-28" version="1">MKSYRAKIRVSAKSSRVAASIHDALAPDLKRLPKTEGRAAISLKNSDIIFDIETPDIASLRASINSYIRLADASYKCIVTAASNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK0</accession>
    <name>K0IJK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32850"/>
    <dbReference type="EnsemblBacteria" id="AFU60200">
        <property type="protein sequence ID" value="AFU60200"/>
        <property type="gene ID" value="Ngar_c32850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32850"/>
    <dbReference type="HOGENOM" id="CLU_021603_4_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3285-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="16259" checksum="3A246B941C2B94DF" modified="2012-11-28" version="1">MIHGGAGTGKIRKSSKHAQDISKALENSVSTGYDILEKSDGDAAAVNAVESAVASMEDSGLFNVGIDSCLILDKRIEMNASIMNGKDLAAGSVGMVQHMQNPVKLARQVMERTDHTMFVSDGPLELAKLFNITVAPVEPFLFIIDFHLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM2</accession>
    <name>K0IJM2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5'-phosphate oxidase FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24810"/>
    <dbReference type="EnsemblBacteria" id="AFU59403">
        <property type="protein sequence ID" value="AFU59403"/>
        <property type="gene ID" value="Ngar_c24810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24810"/>
    <dbReference type="HOGENOM" id="CLU_118461_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2479-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15772" checksum="A737FA8AA407BEAB" modified="2012-11-28" version="1">MVQIDEDIIRLIIKQDHVVLVGSVSAEGIPNISPRYVLGILQNEKLLFADAFTNKTFHNINSWPKVSVAIFDRDTRGGYQLKGSAEEVTDPKLVLQAETRLKEFGILEKPKKVWTLAVKEVFSLEPSAKSRHSFSPYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN6</accession>
    <name>K0IJN6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative asparagine synthase</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25050"/>
    <dbReference type="EnsemblBacteria" id="AFU59428">
        <property type="protein sequence ID" value="AFU59428"/>
        <property type="gene ID" value="Ngar_c25050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25050"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2484"/>
    <dbReference type="HOGENOM" id="CLU_050152_0_0_2"/>
    <dbReference type="OMA" id="PMEVVNC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2504-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="298" mass="33442" checksum="44C90EF00DFB9619" modified="2012-11-28" version="1">MLLSGGLDSSILASILHPKYSVAAGFGSDAPDLAHARQVAGKYSGRHVEVVFDQNRMAELVEQVIQVFKTFDPIEIRNSAVALAGMEQAKSDGHSAIMTGDGGDELFAGYNYLARYYSDAQKLDLELRRLWQIMHFSSRKLGEHIGVKVKTPFLDGEFISFAKSIGVSEKVGEHNGKKWGKLILRRCFETTLGDLVWRQKLAQEQGAATGKYQKYVEEMIDDLTFANKAKIAKELDNVTIRSKEHLHYYAIFRSYFPPPKEEEREVDCESRCPECRGCMARDGRFCRTCGAFPVTPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJR4</accession>
    <name>K0IJR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60320">
        <property type="protein sequence ID" value="AFU60320"/>
        <property type="gene ID" value="Ngar_c34050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34050"/>
    <dbReference type="HOGENOM" id="CLU_3163254_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3406-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="47" mass="5299" checksum="B194AF217EC337ED" modified="2012-11-28" version="1">MSKELSDIWHTNELFVKLGVANFTKVVQGSDSSGISWTEKRNKVPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJS4</accession>
    <name>K0IJS4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59473">
        <property type="protein sequence ID" value="AFU59473"/>
        <property type="gene ID" value="Ngar_c25510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25510"/>
    <dbReference type="HOGENOM" id="CLU_2748324_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2550-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7676" checksum="23680A7EFA072574" modified="2012-11-28" version="1">MTFAGPLMKTSGAHDYIYSTEQLLQMDIATPDGGMITIEITDLIQVANGKAAKQKIYYDPREFAKAFGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ7</accession>
    <name>K0IJZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60445">
        <property type="protein sequence ID" value="AFU60445"/>
        <property type="gene ID" value="Ngar_c35320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35320"/>
    <dbReference type="HOGENOM" id="CLU_2340277_0_0_2"/>
    <dbReference type="OMA" id="FEYSTIG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3533-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11018" checksum="C96825F4E82245ED" modified="2012-11-28" version="1">MYTISKILDLAVLGLLVVFFIGVLAFEVAYFGLSEPIIPIPHEAEPYFEVLPWVILGLLMADIYVKYVKLGSDWRALVRQHWPDIITDPGVHADQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK45</accession>
    <name>K0IK45_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase II large subunit</fullName>
            <shortName evidence="11">Pol II</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="11">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">polC</name>
        <name evidence="13" type="ordered locus">Ngar_c35970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EC" id="3.1.11.1" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35970"/>
    <dbReference type="EnsemblBacteria" id="AFU60510">
        <property type="protein sequence ID" value="AFU60510"/>
        <property type="gene ID" value="Ngar_c35970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3605"/>
    <dbReference type="HOGENOM" id="CLU_001154_0_0_2"/>
    <dbReference type="OMA" id="KRRNCDG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="PTHR42210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016275">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolC_DP2" evidence="12">
        <location>
            <begin position="21"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU60510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125573" checksum="86369B6A4B40BD8E" modified="2012-11-28" version="1">MMLEEAEARLKDVRMPAYYRRYQQDILENVHKNYQHALKARRRGIDAADIVEPKIAYDLADRVAKMHEIDIADRLRALLTTTTKEKAALKIAEEIAAGEYGSGDLKTRLDNAVRVSLAVVTEGVTVAPLQGISDVTIKNNADGSQYLSVSFAGPIRSAGGTEAALTMLIADHARKVAGLGKYIANSFDDETGRFVEELRIYEREVMGFQFKVLDEDVIKCISNLPVELDGVDTDPVEVVGHKGMRRIATDRVRGGTLRVMNDGLIGRSRKLLKLVETLKLDGWGWLKDLKGAIQTGDDDAAHHRMSEVITGRPVLSMAKKIGGFRLRYGRCYNTGFATVGIHPAVPALLNYAIVAGTQIKMDMPGKASTIALVDTLEAPLVRLDDGRVMPVPTVEQAERIRTRVNKILYLGDMLISYGDFLENNAQLPPASYVEEIWAQQLKSKLPALPVVDSNRERLIQLAENPLVAPSLEEAFDISSKLGIPLHPRYSFYWDTVGLDEALYLKDRLADDNEIPNDAKLKDILERLGVAHSIARDKIRVDNNDQAASLRRLLGGPIVEAKDTIEFVTKSSGVVVRPKFASTIAVRVGRPEKAAERKMKPPVHVLFPVGPKGGATRDILKACKEEDSFYTEIANRYCDNCKIPSIGTHCRTCGASTMLRNLCIQCRGEVEEGEKCARCGKEGRTYSSTNYPLKAAIEHAKKKLGVAPEEPFKGVKSLMSRHRSAEPLEKGILRQKHGLHAFKDGTIRFDATNEPLTHFKPAWISVSIEKLRELGYTRDYLGKELVSPDQIVELMMQDVIIPIDSARHLVNTAKFIDEELAKLYELEPFYNVNSVEDLVGHLVVGLAPHTSVGIMGRIIGFTDSQVCLASPVWHSAKRRDCDGDADSVMLLMDAFLNFSFDFLPDKIGGLMDAPLLIQPVVLPHEVQRQAHNVDIAGVYPVEFYEATWKQGKAADAAAMIETIKNRIGDERQFFGYSFTHFTNALTTKAQRSAYSTLNTMEEKLKMQFDTAKLINAVDADEVAAMVLTTHILPDIMGNMRSYSSQTFRCTACGAKFRRMPLVGKCAECGSELVQTVTRGAVEKYLGIATGMCQQYKINDYLRSRVESIAMELKLIFKEEKKVQSSLTEFMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKB9</accession>
    <name>K0IKB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18750"/>
    <dbReference type="EnsemblBacteria" id="AFU58807">
        <property type="protein sequence ID" value="AFU58807"/>
        <property type="gene ID" value="Ngar_c18750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18750"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1859"/>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OMA" id="IGVHMDR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1873-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="388" mass="41506" checksum="8A1AEE39DC75BBE2" modified="2012-11-28" version="1">MPGYDVIVAGGSVSGLLAAREAAAGGLSVAVLEEDSEIGTPEHCGGLVSIAGIRNIGIVPDASAVENTKIARAKILSPSSGFEISAEKQKVMVLDRRAFDKQIAFQAQKLGAEIKVKCAMRSFSKKEDDGPTYIVKTSEGDLVCKYFVDARGVASIIARNREGVLQSAQYEVYAPWIERDTIEVAFDNQRYPGFFAWIIPTAQGSGKVGVAGRGINAASALQSYIDGKGKCSIVRKVYASIWVNGPMENLVSDRMIIVGDAAGQSKPTTAGGIYTCGMGGVLAGRAVAEAARKNDDRLLAQYEKDWRSMFGAEFEKMLLARKLLERLDNKAIDELFSAVPPEKIEEASASGDFDFHSAALAKILGAKSATRMAKALLGNEIRRLIDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH6</accession>
    <name>K0IKH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58937">
        <property type="protein sequence ID" value="AFU58937"/>
        <property type="gene ID" value="Ngar_c20050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20050"/>
    <dbReference type="HOGENOM" id="CLU_2406455_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2003-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="9796" checksum="6A5B574FFEFA5CCD" modified="2012-11-28" version="1">MNKTTVLVGISFIVAAVVLVTMGFLEWFAHENCMEIIRAFERGESNVLPACPPEPSGKFLIAALPVGIGGAVILVMGVKNRSLLSSPKPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKL5</accession>
    <name>K0IKL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative restriction modification system DNA specificity domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c29140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29140"/>
    <dbReference type="REBASE" id="55349">
        <property type="entry name" value="S.Nga92ORF29130P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59833">
        <property type="protein sequence ID" value="AFU59833"/>
        <property type="gene ID" value="Ngar_c29140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2892"/>
    <dbReference type="HOGENOM" id="CLU_021095_2_1_2"/>
    <dbReference type="OMA" id="KRWFVDF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2914-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="236"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="436" mass="48840" checksum="5F773A35275BD2AC" modified="2012-11-28" version="1">MMKEKTKTKFKETEIGKIPEEWEVASVSDLADIYIGGTPKTEVGEYWNGEIKWASAKDVSNCRSRYICNTERTITNTGIENSNAKIFPKDTLVITSRGTVGKLALLGEPMSFNQTCYGLVAKKQTIPLFLYYKLKDSVDKIQSASYGTIFDTITTKTFNELKLGIPPLHEQHSIVRILSDLDSKIELNQQMNKTLEEMGRAIFKHWFIDFEFPNEEGKPYKSSGGEMINSDIGTIPKGWRISSIGHEIEVGGGSTPSTSESSYWDGGDINWATPKDMSSLTSPILVDTQRKITTKGLDAIGSRKYPRGTLLMSSRAPIGYLAISDIATAVNQGIIAMVCTQSLSSYFMLNWCKFNMEKIENRANGTTFREISKSNFRTMGILVPPKSLLSRFDGYARMIYSHMSTNIRHSYTLQNIRDSLLPKLMSGKIRVPVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKU4</accession>
    <name>K0IKU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60003">
        <property type="protein sequence ID" value="AFU60003"/>
        <property type="gene ID" value="Ngar_c30870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30870"/>
    <dbReference type="HOGENOM" id="CLU_353257_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3087-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="795" mass="84836" checksum="D022EAC18154A0FD" modified="2012-11-28" version="1">MSRKKGAAVAVIIVVVAAIGGFAAYSAMPRQQEDAGPEPVLTTIDRRNESDSDSSTTTIAENASGQQPQQQQQNNNTGTVIANNTVVINKPVYRNNTIIYQPVTINLENYRTTINHHIELENDDDSATKPADKSHSITIRAKRIQSEGWSEKFTDDGVGMFTAVYDINGNIIKTGYADERGFTVSGLEDKLYFVYPADCNDCGNSKKNDIVFMQWEDGSKNRPRLVPADSNVTASYGLVVPERPKQVPLIPPGETGTAAEPEMTLKAHNSTYIYGWVQVSVQLKNKVESYDEILVSIYAPDGTLQDSFSYPEQQGFFASRETGEGDYRIVVTYEYDKGTARAEITHPIKFATPKFVNLSATEDNNTGTMRVDGMLEGGLAGENITIALNDPDDQTIKKYAMSFGTRPIFTLFIPGEEARAIFNETGNYTFVVTHLPTGVQGSVTLSHNNNANETEEASTTPMNVSGNAGRSERADMAVQGSDVYVVWQDDTSGHHEIMFAKSSDSGATFSEPVAIGRSEQGGSSLVPDIVVSGNSVYVVWADYNSQNQSAIALRSSNDSGKTFGDTLILGGNYTGENSDPHVAIFKGNIYVLWVAAGAVEGSAGDLMLARSSDGVEFEAAVVGSNATNPAMTSSDSALYLAWQQQLSGNATEGRGEGVNVFASSSDGTNFETAEMLPEMTIQTMAASADAVYIAGVTNNNTVTIARSNGSASFGDALEIGNGASSHVAASGAGVYVAWVQDGKVLLASSSDGGETFEVASVVGDDEGSWPKVAADGNVYMAWTEGSDIMVVVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKW6</accession>
    <name>K0IKW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60033">
        <property type="protein sequence ID" value="AFU60033"/>
        <property type="gene ID" value="Ngar_c31170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31170"/>
    <dbReference type="HOGENOM" id="CLU_1465153_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3117-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="22169" checksum="84B74783B4C68D3E" modified="2012-11-28" version="1">MVWLGTRGFALKKSTHRRQRIELQHKTLVFMASMIAKAFLMAMVSSQVFCRSIDPTIVFMQCGPNAAFMGGSVAAVALMGIVFGYYIVRLKSFNDIFPQVMKADFIVTAMYLGVAFFAPDTIAARVMMWLFGMWIIGMVLAPFSKERTLFKKITEYGSIAALGGFLALQVIPVPIFEGYDSSSTIGMILSSVLAPFGGGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC2</accession>
    <name>K0ILC2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tellurium ion resistance family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">terC1</name>
        <name evidence="6" type="ordered locus">Ngar_c33980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60313">
        <property type="protein sequence ID" value="AFU60313"/>
        <property type="gene ID" value="Ngar_c33980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3396"/>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_2"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="348" mass="38463" checksum="A6BC57CB0053AE50" modified="2012-11-28" version="1">MESLPALYGNGITLWIVFAVSVGLAIAIDLGLTGKVRKLLSKQKDEKSDSSPSEEKQPFKQALMWTIVWIGMAGAFAVLVYVSLGYDKMLEFVTGYTLEKSLSVDNMFVFLLIFTTLAIPHAFQHKVLTVGILSAIAMRIPLILVGVSLLESFHWMVYVFGGLLVLTAVKMLLQKKDKKIEVEKNIAVRMLRKVVPVTTELNGDKFFTKKNGILFATPLLVALVMVEMTDLVFAIDSIPAILAITSDPFIVITSNIFAILGLRSLYFLLAGMMEKFHYLKPALVALLLFVGFKMIAVDYVKVPIAISLAVIGGILGIAIGLSYLKAKRQYNHQEKSAIERATREDAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD4</accession>
    <name>K0ILD4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57014">
        <property type="protein sequence ID" value="AFU57014"/>
        <property type="gene ID" value="Ngar_c00640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00640"/>
    <dbReference type="HOGENOM" id="CLU_3338590_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-64-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4266" checksum="F8352D46964EEC18" modified="2012-11-28" version="1">MFLQLSKIPHFTTMQKFAARISGTLLERIIASFSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF2</accession>
    <name>K0ILF2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">Ngar_c34630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34630"/>
    <dbReference type="EnsemblBacteria" id="AFU60378">
        <property type="protein sequence ID" value="AFU60378"/>
        <property type="gene ID" value="Ngar_c34630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34630"/>
    <dbReference type="HOGENOM" id="CLU_074878_2_0_2"/>
    <dbReference type="OMA" id="MKAYQRQ"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="68"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="213" mass="22724" checksum="00C887E38B53D0C0" modified="2012-11-28" version="1">MAPPAAVPDFMLEFASFLLKSNSLRFGVFTLASGKQSSYYIDLRVLPSFPAYFRLAINALKGTVTKNVGQFDTLASVPTSGLVFGSALAYEMSKPFIYARKESKGYGTGKTIEGFLKAGSKVVVVDDVATTGTSVSSAVDIIRANGAIVEDVVALVDRHEGANERLKKIGVRLHAVAGINDIVSALYKAGLIDENALESVMKQMAAKGEYETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG8</accession>
    <name>K0ILG8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6 10">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Ngar_c34950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the aTrm56 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6 10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34950"/>
    <dbReference type="EnsemblBacteria" id="AFU60408">
        <property type="protein sequence ID" value="AFU60408"/>
        <property type="gene ID" value="Ngar_c34950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3497"/>
    <dbReference type="HOGENOM" id="CLU_123709_0_0_2"/>
    <dbReference type="OMA" id="VVHLTMY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3496-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="126"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU60408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="19403" checksum="CB75F28B4BFBE946" modified="2012-11-28" version="1">MKVSVLRIGHRLVRDDRVTTHAALVARAFGADRIYMTGVDQSVSDTVAGVTKRWGGKFEVQVIQDWKGLAKAWKKEGGKVAHLTMYGINIDEAAERLRKEERILVIIGAEKVPREAYELADYNIAIGNQPHSEIAALAIFLDRMFKGKQLKKELAGGRLKIVPAARGKQVREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL1</accession>
    <name>K0ILL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59542">
        <property type="protein sequence ID" value="AFU59542"/>
        <property type="gene ID" value="Ngar_c26200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26200"/>
    <dbReference type="HOGENOM" id="CLU_2010160_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2620-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="13937" checksum="E933CC7091E5CF10" modified="2012-11-28" version="1">MTEIEQKIKEAFGNIDNLTKFKKRNKLQASYIEYDKFSDSNLHEGYFCYNCIYWINQGGGKCMLVDNEGPDVLGKTSSVIAPHGCCSQYEPNYDKLHDTRTPTAGLNIDTEKNKEKVTTADVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILN8</accession>
    <name>K0ILN8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb2</name>
        <name evidence="6" type="ordered locus">Ngar_c02310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02310"/>
    <dbReference type="EnsemblBacteria" id="AFU57179">
        <property type="protein sequence ID" value="AFU57179"/>
        <property type="gene ID" value="Ngar_c02310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02310"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="SDEQEHC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="292" mass="32297" checksum="E7786FADB9013560" modified="2012-11-28" version="1">MCGKDQQLVTDLESGEIVCSKCGLVSSDRVQESRAEWRIFNSESNGRSRVGSPSSLAYHDMGLATVIGKENRDSSGHQLEPSMNASIQRLRTWDFRSQAHSPTKRNLMHAFSELGRLKDKLGLSDAIMEKTAYLYRKAHEKHLVRGRSTSSILAAAIYASCRELGASRTLKDVAKATDIKRKAISRSYRILVLELDIKVPLADPMKCIAKIANSAKLTEKTKRMAMDTMNDLIGKEISAGKLPMGLAATVLYMSCLANGESKTQKDIADMAGVTEVTIRNRFKDLKAKLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT6</accession>
    <name>K0ILT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57329">
        <property type="protein sequence ID" value="AFU57329"/>
        <property type="gene ID" value="Ngar_c03810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03810"/>
    <dbReference type="HOGENOM" id="CLU_1500324_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-381-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20196" checksum="7A6BCFE1F3BDDD31" modified="2012-11-28" version="1">MYYIVIFVLQYNMRAVMDSDALIKITKSSVKETVLSNISTDIPKKVEQETVDDGKKSGHPDAVVIERNIQAGKIKVSETRSSDVSERIIASLNISGGESDSLRLFSNNRSNYDCIITDDQKFIDLIDGLEIPFLTPSALLVYLVNQKRVSPDQALQYLDKMKPMISKEEYILTKEELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW0</accession>
    <name>K0ILW0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS and Zinc Finger C2H2 domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c04470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57394">
        <property type="protein sequence ID" value="AFU57394"/>
        <property type="gene ID" value="Ngar_c04470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04470"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-446-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23006" checksum="A3BE71C7E1C475CC" modified="2012-11-28" version="1">MSYVPDDISSLLSEPIEHYINTNVVILEGDRFTDEALSLMKEKGVRSVLVSHVGEVVGIVSKTDILFKVMSQGRNPGKVRLREIMTSPVLAVNPHNTMQETLSLMDKHVIRQVIVSSHSAVLGMVSRDDIFEKIHMATMSTAHTAIKGTPVCIINPKAIVYMKDITTAKLVCPYCESPFDTKEGLSSHIDRLHSGSGVLEGDVRRMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY6</accession>
    <name>K0ILY6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c28830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28830"/>
    <dbReference type="EnsemblBacteria" id="AFU59802">
        <property type="protein sequence ID" value="AFU59802"/>
        <property type="gene ID" value="Ngar_c28830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2859"/>
    <dbReference type="HOGENOM" id="CLU_049427_0_0_2"/>
    <dbReference type="OMA" id="PGVSHNY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2883-MON"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="7">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="7">
        <location>
            <begin position="240"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="38639" checksum="5025BE1B45AF6B84" modified="2012-11-28" version="1">MQANQQQLDEIDKKLLNEIQWVFPLVDRPYLEIANRYSISEQDVMRRIKALKEMGLIRQINAIFDTRRLGYKSALVAFAVRPDKLDQVADRVNEHPGVSHNYERNHEYNMWFTLAVPPGSDMKKDLDRMAALDGVIKYRVLPTLKLYKIGVRLDMVNDDAEKPKPTDEVKEMNPEKVQLTERDKEFIRELQKDLAVVQEPFKEAADNLGITTGELFAKAKEYESTGIMRRFAAILRHRDAGFVANGMVVWNVPEDKIDEVGFKLAAFPQVSHCYRRPVYPDWRFNLFSMVHARSLEAAEKMAVEMSKTIGINDYKILFSSREFKKERVKYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM53</accession>
    <name>K0IM53_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30960"/>
    <dbReference type="EnsemblBacteria" id="AFU60012">
        <property type="protein sequence ID" value="AFU60012"/>
        <property type="gene ID" value="Ngar_c30960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30960"/>
    <dbReference type="HOGENOM" id="CLU_1412405_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3096-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="21357" checksum="95CBDA9DB5EA29DE" modified="2012-11-28" version="1">MINSALNDKLMQFFNEALAMEHAAEDRIHARVNETPVEQTRQQLQYHLEETRQQQGRLRELVTNMGGSPTTANASLPSIKPATADTITGMVKETAKSVASEESRQTLDAEKELMRIKEDAIIENAEIVSYKLLMEMTDKAGLKDASAKLQQSLQEEVAMANFIACNAPLILSLLWPKLEAPAHGKQERIAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM72</accession>
    <name>K0IM72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60057">
        <property type="protein sequence ID" value="AFU60057"/>
        <property type="gene ID" value="Ngar_c31410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31410"/>
    <dbReference type="HOGENOM" id="CLU_2313878_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3141-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="10890" checksum="FBF50865125AF845" modified="2012-11-28" version="1">MPAEGLPGESMRSLLEAMQNDVTARLYISNKLGTDVFGFLKHDEVELFVSAIAKHKADPRTSVGEAGQAFEDVLRRIDTDKGVDMTPCKGIQELADRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA5</accession>
    <name>K0IMA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c32260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32260"/>
    <dbReference type="EnsemblBacteria" id="AFU60142">
        <property type="protein sequence ID" value="AFU60142"/>
        <property type="gene ID" value="Ngar_c32260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32260"/>
    <dbReference type="HOGENOM" id="CLU_055690_5_0_2"/>
    <dbReference type="OMA" id="CPWHAWK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3226-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11333" checksum="E8EE5562E781E22C" modified="2012-11-28" version="1">MAFVKVAQRGEIKENGGKELNINGTRVALFYANGKYYAIEALCRHQDGSLAPGKIDGEVVECPLHSWHYNIRTGELLDYLEGVKLTTYKVDVRGNDIYIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA9</accession>
    <name>K0IMA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin iron-sulfur binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07670"/>
    <dbReference type="EnsemblBacteria" id="AFU57709">
        <property type="protein sequence ID" value="AFU57709"/>
        <property type="gene ID" value="Ngar_c07670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07670"/>
    <dbReference type="HOGENOM" id="CLU_178207_0_0_2"/>
    <dbReference type="OMA" id="QFHENRD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-765-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10719" checksum="A374876AD18C7735" modified="2012-11-28" version="1">MPIDPNFQANRVATTFENLKVWKNKISNLGIYGTNVAVDFDLCVGDGACIEVCPTNVFDWQGVGADRKALPSRERDCIYCFGCEAVCPKFAIRVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC0</accession>
    <name>K0IMC0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MG4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57749">
        <property type="protein sequence ID" value="AFU57749"/>
        <property type="gene ID" value="Ngar_c08070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.773"/>
    <dbReference type="HOGENOM" id="CLU_331683_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-805-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MG4" evidence="2">
        <location>
            <begin position="821"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1000" mass="106554" checksum="524F71257D439E71" modified="2012-11-28" version="1">MALENDIRLDMNFATSIVEAGAATYPIGYVRLVSNDTSEPVIAPSDLEIGLLSTDASIAFVPSRVTIPAGSDYAQFNVEVSDLAGKTEISAQYGDQKVTRTFKVVDALNLIEDIDLVINLASNKMQVASEMPFSVYLEDNGNILQAPEDIVVKLDYESSLVQLDSDSLVIKKGSYYATGTIKTLEKSGNAFIRAESKVGTIGHLNTVTNVEISQTQPASLKVYVFPDQVSLHQNTIDIFVGVLDAAGQPTLAAEDIKLELFSSAYQLAGIESAPAVIKKGEFGFYLRQYMRFYGDQEVTIGASASGLGSSTATFKVLEDSLGPTHPKALDRTLKVFTVDNMPSDSDSIAVYQLNAIERDDDDVDCNHNGDLTDDGDDCDNDGSFDTHRDSNKDGVINEKDWHPVDDLGDGALYPIDSISIYSPTQGNLNIVSGDNLAARVFDPGYISSGSSYGTATILSGRQANNVDISVSLSNFAVGSNTLTVVGGLNPVQTKIFSPGGYASDSSYRVLFDRNGFTDLFFITLDSSGRPSNSDKGVKYLVKPINELTEINPGSSFASMHISENSFKTGSAIVENTIKKISAVPVGVNSDSRLQTTSDMHLLFHTGTASQVLLPFDSIVAFSKAHPIGIIQLRDVSGNPVLAPDDVAVRLFASSLSNVLPVSVVTIPKGKSFASFDVATFGRADNFTIYATADGLQSSSVMLAPVVAELPASFIGTTTFTASVPAVITVSTPIPNVTISWGTSSGLSLGDKTTFKPAGNSYVATAQVISENPGTFTVDATLLKDGFKPTRITKEVMVGQYHRQMNAILVDNGAAILAYNQPVMMKVLVQDVNGAPVPGATVKVEDSGPHGLMFVSSVTTDASGTASFIYTPTNIDKSSNLITLMVTAYKDGYQTSRYSKIVEIDGSSTVLPPVPIIGNMFAGLPSWTSYAVLGGVAAVGSGIYMLKKQKNPEDEEPLIEEAGAAKETTEKAEAAEAIKETVVEEAIEEDKEDDETEEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF7</accession>
    <name>K0IMF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57864">
        <property type="protein sequence ID" value="AFU57864"/>
        <property type="gene ID" value="Ngar_c09220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09220"/>
    <dbReference type="HOGENOM" id="CLU_3263938_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-920-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="41" mass="5073" checksum="CD96D2EFA04A6155" modified="2012-11-28" version="1">MKRKRRTDPAVITYALYLYFNSRSFRLWQPNPWHQSREGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI9</accession>
    <name>K0IMI9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60327">
        <property type="protein sequence ID" value="AFU60327"/>
        <property type="gene ID" value="Ngar_c34120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34120"/>
    <dbReference type="HOGENOM" id="CLU_2730549_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3413-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8013" checksum="210658BC5BF8058F" modified="2012-11-28" version="1">MQKIDGWMDRDVVAAMNLSIRGRAFLAKSEDEFERPKGDAGEAMKGNPMTAPVILRVDASKLIFRHQPKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW1</accession>
    <name>K0IMW1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58314">
        <property type="protein sequence ID" value="AFU58314"/>
        <property type="gene ID" value="Ngar_c13770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13770"/>
    <dbReference type="HOGENOM" id="CLU_2519876_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1375-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="8623" checksum="77A1943175E28C29" modified="2012-11-28" version="1">MVIVISPPKFGKTARVIVAAILLALGLILTFLVTGVAVSITATEFESDALTIIAFSPVGYVLVFSGFAVGLLLGGMSLIRSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW8</accession>
    <name>K0IMW8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58349">
        <property type="protein sequence ID" value="AFU58349"/>
        <property type="gene ID" value="Ngar_c14130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14130"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1411-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15358" checksum="D7019E6F37F9B4DE" modified="2012-11-28" version="1">MSQEQQLSPGRGIELSRAQSILVVDDELDIVTIFRQALSRYGYSVFGFTDPTLALEHFRLNAQDYALVISDVRMPQMSGFELAANIKAIKPDARIVLMSAFEVSDLEFSTSAVKTSDFLRKPVDIRTLVQKVKGAMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN16</accession>
    <name>K0IN16_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative inorganic polyphosphate/ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16560"/>
    <dbReference type="EnsemblBacteria" id="AFU58589">
        <property type="protein sequence ID" value="AFU58589"/>
        <property type="gene ID" value="Ngar_c16560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1631"/>
    <dbReference type="HOGENOM" id="CLU_008831_0_2_2"/>
    <dbReference type="OMA" id="NEVAIFP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1654-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="288" mass="31931" checksum="FA5B9186F16EBB89" modified="2012-11-28" version="1">MVAGGDRGILDYFHKVKTDSAPVLGIYETDSTGFLAQLEVRDIESAISRLKRGDYSVDEVFRLSVKVDGKQVDPVLNDVAVFPSKSATLMEHVLRIDGNDIWHDNSDGVIISTPTGSTAYSMSAGGPMVLQKAPVFLVVSVNSLDNTRRPLVVPNDSKLEITDITSRYHCEVVVDGGRRMRIKDNLECSKHEFPARLVRLAGDSSSAASLMAKKVQLAEDMLRMPPSAKLILKTLEYEGALSQKDLATRTMLPERTIRLSLSHLINQGYVKKKTSLRDARQRIYELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN39</accession>
    <name>K0IN39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c17710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58704">
        <property type="protein sequence ID" value="AFU58704"/>
        <property type="gene ID" value="Ngar_c17710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1747"/>
    <dbReference type="HOGENOM" id="CLU_1269985_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1769-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="24226" checksum="3D94956177196FB8" modified="2012-11-28" version="1">MYSGELEVQAKRKALAVLQDEITRILNSSRDLSTLTASLMKGDDKDIQHCLERMRNTEEEVENLRRKITREVAEIGSLMANREDILRTAYIIDDIAGYISGVAFRLANMKPSSLKKASFDDDLKQLVGMVVDTIFKLNEMGRALSINPANAIDLAQDVQKLERQVDAKYRAVIIKALNEISSTKDLLLLKDAVEGIEGMVDKCQEASDSFTILALSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN67</accession>
    <name>K0IN67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative IS-4 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02580</name>
        <name evidence="2" type="ordered locus">Ngar_c03210</name>
        <name evidence="3" type="ordered locus">Ngar_c03920</name>
        <name evidence="4" type="ordered locus">Ngar_c07220</name>
        <name evidence="5" type="ordered locus">Ngar_c09910</name>
        <name evidence="6" type="ordered locus">Ngar_c10350</name>
        <name evidence="7" type="ordered locus">Ngar_c10610</name>
        <name evidence="8" type="ordered locus">Ngar_c11090</name>
        <name evidence="9" type="ordered locus">Ngar_c11240</name>
        <name evidence="10" type="ordered locus">Ngar_c19120</name>
        <name evidence="11" type="ordered locus">Ngar_c19940</name>
        <name evidence="12" type="ordered locus">Ngar_c27930</name>
        <name evidence="13" type="ordered locus">Ngar_c31220</name>
        <name evidence="14" type="ordered locus">Ngar_c34210</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Enrichment culture Ga9.2</strain>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57206">
        <property type="protein sequence ID" value="AFU57206"/>
        <property type="gene ID" value="Ngar_c02580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57269">
        <property type="protein sequence ID" value="AFU57269"/>
        <property type="gene ID" value="Ngar_c03210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57340">
        <property type="protein sequence ID" value="AFU57340"/>
        <property type="gene ID" value="Ngar_c03920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57665">
        <property type="protein sequence ID" value="AFU57665"/>
        <property type="gene ID" value="Ngar_c07220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57933">
        <property type="protein sequence ID" value="AFU57933"/>
        <property type="gene ID" value="Ngar_c09910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57977">
        <property type="protein sequence ID" value="AFU57977"/>
        <property type="gene ID" value="Ngar_c10350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58003">
        <property type="protein sequence ID" value="AFU58003"/>
        <property type="gene ID" value="Ngar_c10610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58051">
        <property type="protein sequence ID" value="AFU58051"/>
        <property type="gene ID" value="Ngar_c11090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58066">
        <property type="protein sequence ID" value="AFU58066"/>
        <property type="gene ID" value="Ngar_c11240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58844">
        <property type="protein sequence ID" value="AFU58844"/>
        <property type="gene ID" value="Ngar_c19120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58926">
        <property type="protein sequence ID" value="AFU58926"/>
        <property type="gene ID" value="Ngar_c19940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59714">
        <property type="protein sequence ID" value="AFU59714"/>
        <property type="gene ID" value="Ngar_c27930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60038">
        <property type="protein sequence ID" value="AFU60038"/>
        <property type="gene ID" value="Ngar_c31220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60336">
        <property type="protein sequence ID" value="AFU60336"/>
        <property type="gene ID" value="Ngar_c34210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02580"/>
    <dbReference type="KEGG" id="nga:Ngar_c03210"/>
    <dbReference type="KEGG" id="nga:Ngar_c03920"/>
    <dbReference type="KEGG" id="nga:Ngar_c07220"/>
    <dbReference type="KEGG" id="nga:Ngar_c09910"/>
    <dbReference type="KEGG" id="nga:Ngar_c10350"/>
    <dbReference type="KEGG" id="nga:Ngar_c10610"/>
    <dbReference type="KEGG" id="nga:Ngar_c11090"/>
    <dbReference type="KEGG" id="nga:Ngar_c11240"/>
    <dbReference type="KEGG" id="nga:Ngar_c19120"/>
    <dbReference type="KEGG" id="nga:Ngar_c19940"/>
    <dbReference type="KEGG" id="nga:Ngar_c27930"/>
    <dbReference type="KEGG" id="nga:Ngar_c31220"/>
    <dbReference type="KEGG" id="nga:Ngar_c34210"/>
    <dbReference type="HOGENOM" id="CLU_057817_0_0_2"/>
    <dbReference type="OMA" id="HFLTHER"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-258-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU60336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="405" mass="46495" checksum="53949AA509EA8BED" modified="2012-11-28" version="1">MRTLPIQCGTFTQEPTDKHFLTHERVLGNAVNVLLPVFRPADFRKRRYSVVDIANSVVYACTGGTSITQACCTLASTPSRRDVQYHVSKIDISWIQSAANRLLQKRVAETLHNRAVDIAIDMTDVPYHGEPENEGDVRRGRARSGTTHFFTYASAYVMLHGRRFTLATRYIREGEALVGVVRYLLAEVQKASIVIKCLFLDKGFFTAAVMSYLNSMRIPYIIAAFPRGRKGGTLSRLTRKRRDSFVVPDCEMTDSATGEKCTFRLYAVAKYRKKRYRKKRGVQYMYYAAGLVNIPVGRMFDEYRRRFGIESSYRAMGKSRARTSSRSPALRFLYVLASLVIQNEWVYIKWQYLSKATRGRYGRRYDAEFTYFHMLLFLRLGLEQKYGAVYSVQIKNSRSVIIDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN78</accession>
    <name>K0IN78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58899">
        <property type="protein sequence ID" value="AFU58899"/>
        <property type="gene ID" value="Ngar_c19670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19670"/>
    <dbReference type="HOGENOM" id="CLU_1922867_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1965-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="14389" checksum="04E52363631F6D9B" modified="2012-11-28" version="1">MFIDGAVITSNLSSVSTLVMWIVISLVASLALSHRLTFVRGGSEQEQAKGQRIIVGGILGGVVMYLAPYLATWLTGIDYRNPPANLPPQLVSMVGNLLTMIQYIGVAVIIGGITWGAIELTRNRHILTGERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN94</accession>
    <name>K0IN94_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aniA2</name>
        <name evidence="10" type="ordered locus">Ngar_c20470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20470"/>
    <dbReference type="EnsemblBacteria" id="AFU58979">
        <property type="protein sequence ID" value="AFU58979"/>
        <property type="gene ID" value="Ngar_c20470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2024"/>
    <dbReference type="HOGENOM" id="CLU_032707_0_0_2"/>
    <dbReference type="OMA" id="FMYHCHA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="9">
        <location>
            <begin position="312"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="409" mass="45505" checksum="D9E53233181A9997" modified="2012-11-28" version="1">MNFGDKVGASAAASPVHREYTLVAEDAELEIAPGEVVKPWTFNGTMPGPTLRFTEGDNVTIHFINKTPLIHTVHFHGNHDEKNDGVLPQIIPAENYTYNFIADPAGAFMYHCHAYPTSLHIRMGMYGSIIVDPKDSEVLKPAKEFALVLSEFDPDNQDNFVAKYYPVNGYIDQYMGENALKIKQNELVRLYVINIGTTIPYSFHLHSTVFKVYASGLPSNDPIDAQTIEIGPGNAAIVEAVWKSPGTYMFHSHGFLEERGNMGAVRVLSDGSGEQLSESVSMIDWQYELQKELQKPTVIDYDNLSGSASAQSHSSSAHGGTTVKIVKGAWDKNQRDYYEPAEITVEEGAVINWINEDGVVHTVTSKQQGLFDSSIIAAGQEWQYQFAEEGEYDYYCIVHPWMEGIVHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB9</accession>
    <name>K0INB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small-conductance mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59104">
        <property type="protein sequence ID" value="AFU59104"/>
        <property type="gene ID" value="Ngar_c21740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21740"/>
    <dbReference type="HOGENOM" id="CLU_1567209_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2172-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="18238" checksum="86A9A14B71D5D92E" modified="2012-11-28" version="1">MSARTGQAEYMSEVPDADINTEPAIEGRPLDIPAATSTAVDNSYVWDEILISLIIMAGTVAVYYIVRYFINRAAESLAIERGQLKGIYSITKLILLVIAITIIIFQFSSLSGVAAGAISIVAGTIICFSSRNTISNALPEYCSLHQSPSRLVTGYAHLMMNGISATSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC1</accession>
    <name>K0INC1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c21840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21840"/>
    <dbReference type="EnsemblBacteria" id="AFU59114">
        <property type="protein sequence ID" value="AFU59114"/>
        <property type="gene ID" value="Ngar_c21840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21840"/>
    <dbReference type="HOGENOM" id="CLU_586111_0_0_2"/>
    <dbReference type="OMA" id="GPYHTNT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2182-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="219"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="466" mass="53097" checksum="48C3169000BB3010" modified="2012-11-28" version="1">MDSHSSVPGSKKFVYFPLDKEGQEQKQQSQGERELPRDVLDKLLKALGREALREKTPSLQELEQALQGALLQQQGQEWEQQQQPGSQTGSEGETDSDNSGIPLVRQLMNKGYLKDSPKWLSSKGFNEIGNRMLSDVMKALKAGEYGMHETRDIGSGSLVLDTSKKYEPGDDIRLLNVPKSLLNTIQRMSKDGGKLKLPLQIDVEDFEEYETMQDVRVAVVYCIDLSSTMRYSSMYGDMSRIEAAKRALWSLYLLNRKFFPSDSVYIVGFGALASKVAPNDIPYLKTFEPGSDFLHYTNYQAAFRLASKMLQKDGALNKRIVLVTDGHPSACFIDDKSEQDKILSQRPYSHFYTPDRQTLDTVKQENSMNLDIASGELVYLCYRYRQVDQYIGERTIVEAKKVHSQNIDIDTIMVSEEDSLLGYVNEMEKYVKGRSYYINPADIDKVLLTDYLNNKKQQTIRAHSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE0</accession>
    <name>K0INE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-isopropylmalate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22810"/>
    <dbReference type="EnsemblBacteria" id="AFU59209">
        <property type="protein sequence ID" value="AFU59209"/>
        <property type="gene ID" value="Ngar_c22810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22810"/>
    <dbReference type="HOGENOM" id="CLU_075000_1_1_2"/>
    <dbReference type="OMA" id="ICLMGET"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2279-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="CHP00062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00162">
        <property type="entry name" value="TIGR00162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="268" mass="29008" checksum="0C02E2B9217F2FFD" modified="2012-11-28" version="1">MSVREIKFVYSSPDRPKLRSPHLVCGFPGSGYVGKLAVDHLIQELPAKHLVDIYSSSFPPQIMIRTDGTADLMKNSIFWWQGEEGQGGTDLLLLTGDSQPSNPDSEYALAEEVLGIAAQFGTQQVFTLAAYITGVFVDKPKVFGTATDLETVKEFVAHNISTMDSGSITGMNGLIIGIAKLRDMKGICLLGETSGYVVDAKASKAVLETLLGIIDIKVDMTNLEKRAKDTEMLIHTIEQQMLASRGGGGKSLEGQQPPQKPRDTGYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL5</accession>
    <name>K0INL5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59584">
        <property type="protein sequence ID" value="AFU59584"/>
        <property type="gene ID" value="Ngar_c26630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26630"/>
    <dbReference type="HOGENOM" id="CLU_1154315_0_0_2"/>
    <dbReference type="OMA" id="CNTCEAS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2663-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_2" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="242" mass="25994" checksum="4690011427A5DB45" modified="2012-11-28" version="1">MMAEDMAQKKLRGSGGYTIARVTDEEQKKGNLGGPELFLAGIGRLDEDRFVKYYCNKCEKEYEGAPAVQYENPNEDLGEGVTLIEKGEYKCRTCGSTIAQYRKFDAPAVAQQQDQVQAPRAEQATSTIPDLAVTPAVAAAATANDSFVPIQSLIGMSAYDSEAMLIGKVEQIGLSREAGNAKITLKIGDRQVSWDGVSKIGDIVLLKMAETRATMTSGGRCHACGYQNEPGSAFCAECGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN3</accession>
    <name>K0INN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59674">
        <property type="protein sequence ID" value="AFU59674"/>
        <property type="gene ID" value="Ngar_c27530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27530"/>
    <dbReference type="HOGENOM" id="CLU_2257461_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2753-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12293" checksum="E8531CFEDA6513CD" modified="2012-11-28" version="1">MIALSDDSTWLRNISGSWRDVKCPCGSTFHFRGKIDELFSWERIHLRHMASDSANHEMLSFYPKDMVIIYHSTSGYVLERRKHRRDEIGELHQARLYGRAKLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR0</accession>
    <name>K0INR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thsA5</name>
        <name evidence="6" type="ordered locus">Ngar_c28900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28900"/>
    <dbReference type="EnsemblBacteria" id="AFU59809">
        <property type="protein sequence ID" value="AFU59809"/>
        <property type="gene ID" value="Ngar_c28900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2866"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="547" mass="58796" checksum="1DA9BF3B60DB4518" modified="2012-11-28" version="1">MSAQVPIVVLKEGTTETKGNQAQRNNITAAKAVAEIVRTSLGPRGMDKMLVDTLGDVTITNDGATILKEIDVQHPAAKMMVEISKATDNEVGDGTTSTVVLAGSLLEKAEELITKNVHPTVVVEGFKKASEKAIETLKEIAIKVDPTDKAFLRKIARTSMASKVVSANSQELADIVVDSVLAVAEKSGDQYRVDIDNIKVEKKAGGSIRDTKFIHGIVLDKEVVHGGMPKRIENAKIAVINSALEIEKTEFDAKININSPDQMQKFIDEENRMLKSMVDKVIAAGANVLLCQKGIDDIAQHYLAKAGILAVRRIKESDMYKLSRATGARIVNNLDELSAADLGFARVVEERKVETDKWVFVEECKNPKSVSILVRGGSQRVVDEAERSVHDAIMAVKDVVEYPYVLVGGGAPEALASLKLREWASSLSGRAQLAAEKFADGIETIPLVLAENAGMDPLDTQVQLRSKSTATGKARFGIDVFNGKVADLAAKDIYEPLAVKEQVINAATEAACMILRIDEVIAASKPKDMPKPGSHGGSGGGMGDMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR3</accession>
    <name>K0INR3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59824">
        <property type="protein sequence ID" value="AFU59824"/>
        <property type="gene ID" value="Ngar_c29050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29050"/>
    <dbReference type="HOGENOM" id="CLU_2766240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2905-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7907" checksum="DF74B0C91B5CF2E0" modified="2012-11-28" version="1">MPHDSSNRLHNNNNSSADLAALTAAAGILGFITAGMLWYHLFSSDDSRRRKKLFKKMKYYRSSLLREMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ4</accession>
    <name>K0INZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60229">
        <property type="protein sequence ID" value="AFU60229"/>
        <property type="gene ID" value="Ngar_c33140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33140"/>
    <dbReference type="HOGENOM" id="CLU_2534793_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3314-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9781" checksum="147F2668613C83AF" modified="2012-11-28" version="1">MRREDRKVTTLMVEKPDIEKIKTAIDQTLGEETSELVFRTLKLVYHIDEDTIVSNPELFRKKIKRMFGDQIVEMILKAISDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP00</accession>
    <name>K0IP00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60259">
        <property type="protein sequence ID" value="AFU60259"/>
        <property type="gene ID" value="Ngar_c33440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33440"/>
    <dbReference type="HOGENOM" id="CLU_2392992_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3344-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10094" checksum="6C45659ECA10B20D" modified="2012-11-28" version="1">MTWSSTQAKFADIHIVTFVLDENLTSDVLLPFGIPEQVTGADFELLPPYNVGEPLIAQAPDGREAIVAANKVVFYPTEIGADDEPTFLEGTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP09</accession>
    <name>K0IP09_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane ClpP-type serine endoprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c33890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33890"/>
    <dbReference type="EnsemblBacteria" id="AFU60304">
        <property type="protein sequence ID" value="AFU60304"/>
        <property type="gene ID" value="Ngar_c33890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33890"/>
    <dbReference type="HOGENOM" id="CLU_024619_1_1_2"/>
    <dbReference type="OMA" id="QMDTPGG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3390-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="375"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="455" mass="48103" checksum="88E78A5B6BD111B8" modified="2012-11-28" version="1">MQQLPAPLLPCSMIKAGLLLLLMFGLLAVSAYAQDPPGSSQDKKKVLWVEVKDFISSATSEDISSAISTASADKSFTAVILALDTPGGSLDATLEIIESLQRSEVPVIGYVYPQGKSAWSAGTMILVATGYAAMAPVTTIGSAQPVSGDQQPINDTKVINALVEKVVSLAEAHGRNETQAARFITHNDNLTPGRALERNVIEAIASSPSELLEKAHNATVVVTGEEERLDTSGAQIVTHQPSPRVLFVNFLANPLIFTTFLAIGFLALIYGLVSPGFGAEIAGAVLIILSLMGQGFDVNWGAFAMLAIGIGLLGYELYSPGFGAIGIGGIAVLAIGSILMITQPVEPLLVTEEHLGNLALLSVIIVAPFGALMGIITYKVWQAKNRQKIEFVLMDKEGVLLEPVSVDKTGFVLVGGEYWQARTTGASLSKGQKVRIVKKQDSFLIVEALSDSISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7G9</accession>
    <name>K0I7G9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57176">
        <property type="protein sequence ID" value="AFU57176"/>
        <property type="gene ID" value="Ngar_c02280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02280"/>
    <dbReference type="HOGENOM" id="CLU_2597854_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-228-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9146" checksum="D281FE7F3E284F27" modified="2012-11-28" version="1">MGSYSERQRVDRKEVFRVNHIAEACAELALYKVMISIDDILDHYSEPALAAMDIELWIFLENMQASGVLTKEAMRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0I807</accession>
    <name>K0I807_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-D-phosphohexomutase</fullName>
            <ecNumber evidence="11">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Ngar_c04600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04600"/>
    <dbReference type="EnsemblBacteria" id="AFU57406">
        <property type="protein sequence ID" value="AFU57406"/>
        <property type="gene ID" value="Ngar_c04600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.443"/>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OMA" id="YIPDYAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-459-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="236"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="358"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="432" mass="46295" checksum="D2B3BC4749EE87A7" modified="2012-11-28" version="1">MKISISGVRGVYGQDLNLHEVSIFASQFASVIKSGKCVVARDTRPSGMIIAQTVVAGLMAGGVDVYNLGVAPTPAAFREARRFGAGVIITASHNPLEWNGLKFIIEGRGLFERELAKMLKSVGGCEGKFGSEFRISSRYVDEVADVAKGGAKVKVGIDPGGGAACGYGERLFKKLGHQYHSINGVAGVSSRGPDPTADELADLRALVTANKLDHGFALDLDADRLVVVNNMGEKLNPDATLLLCVARSLEMGMKKFVTSIDTSVAIEKYVRDHKGKISYSKVGEANVVSKMLEVDAEAGGEGSSAGFIMPKFNMCRDGLLAAATISTLDKKTIDSCLKFASQFVQIRSKITAESAFHKKVIEKLPDIFKRDASSIMTEDGVKAIIDDDSWVLVRPSNTEHAIRVSVESRAGKAQALFKDASEKVQAAYDQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I929</accession>
    <name>K0I929_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57806">
        <property type="protein sequence ID" value="AFU57806"/>
        <property type="gene ID" value="Ngar_c08640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08640"/>
    <dbReference type="HOGENOM" id="CLU_2366302_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-862-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10465" checksum="B33FBA42AF7A1A95" modified="2012-11-28" version="1">MQIIFCTTCQAAAAAIIQNTGFQSSSSFKIEYSFSFFYSSSITSNKNTILKKDGRLISGAYTHSTNKRRSRQATSSDYGATFNTAPELTNEHLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9L9</accession>
    <name>K0I9L9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Cdc48 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10740"/>
    <dbReference type="EnsemblBacteria" id="AFU58016">
        <property type="protein sequence ID" value="AFU58016"/>
        <property type="gene ID" value="Ngar_c10740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10740"/>
    <dbReference type="HOGENOM" id="CLU_2857209_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1072-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="6818" checksum="77AD14C3F495616E" modified="2012-11-28" version="1">MDSMIRNNLGVIIGDTILVSKATGRLAESAIIRPVEAISPIDERYIADALEGIPITEGDNVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAH2</accession>
    <name>K0IAH2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiA2</name>
        <name evidence="3" type="ordered locus">Ngar_c13740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13740"/>
    <dbReference type="EnsemblBacteria" id="AFU58311">
        <property type="protein sequence ID" value="AFU58311"/>
        <property type="gene ID" value="Ngar_c13740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13740"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1334"/>
    <dbReference type="HOGENOM" id="CLU_056590_1_0_2"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="218" mass="23964" checksum="4720457C3D6F5571" modified="2012-11-28" version="1">MQKLAKDAVKLTKGAKVVGLGSGSTVAHIVREMAKLPGKESIEFVPTSLQIKLEAERSALRLVGEERIQDIDIVFDGADQIDSRFNMIKGGGGALLREKILISAAKKVAIVADASKFVQSFNRSVPIEIHPMARSIVWKKLFEMGGKPTLRTLDKGYPFITENGNIILDTTFASIPDPKKKENELKNIAGVLEVGIFTRRADVYYKARDDGTFETIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB60</accession>
    <name>K0IB60_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">aroD</name>
        <name evidence="2" type="ordered locus">Ngar_c16280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16280"/>
    <dbReference type="EnsemblBacteria" id="AFU58561">
        <property type="protein sequence ID" value="AFU58561"/>
        <property type="gene ID" value="Ngar_c16280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16280"/>
    <dbReference type="HOGENOM" id="CLU_064444_2_1_2"/>
    <dbReference type="OMA" id="EFRYARA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="25399" checksum="BFEDC43B362B6800" modified="2012-11-28" version="1">MAAKICASIAPDDVQSITKQAGLAFELGADYVEIRFDFLRPEQLQAAIESAKGIKNRAIFTLRSKDQGGKFAGGEQDRIKWLYRLAEQKPMLLDVELDTLEQNDELADFLEGQKTPVLVSWHDFQKTPPNDQIADILSEMRIYSNYVKIVTAANNVEDSLRLLEMYETAIGLNPIFFAMGEAGVISRVLCTVIGNAPFTYASIEKAVAPGQLTVKQMKKLYDRMKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB75</accession>
    <name>K0IB75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58571">
        <property type="protein sequence ID" value="AFU58571"/>
        <property type="gene ID" value="Ngar_c16380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16380"/>
    <dbReference type="HOGENOM" id="CLU_2340271_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1636-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10983" checksum="634257A324611C99" modified="2012-11-28" version="1">MQQDYEYFFDYFVKEKTPAKEQAAEAYGESTEAGGYGLKTTGVFSNADLEANKQGLQFYRDLDANPNMTFDIANYINSNWNEESNPSFYEASVGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC53</accession>
    <name>K0IC53_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58931">
        <property type="protein sequence ID" value="AFU58931"/>
        <property type="gene ID" value="Ngar_c19990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19990"/>
    <dbReference type="HOGENOM" id="CLU_955170_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1997-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="340" mass="38000" checksum="4106251839FA2634" modified="2012-11-28" version="1">MLVYDGGDVVCTACGAVDDEQRTGLQDEEGCYPSYHPHVHGAVMNNIWSITRSGNGTALLTRGEKEKLGLKTGAYRHTLRSSEEKVVKIIDRVCDRNNLALPESLVKEAVYWATKVTNELASKRKEDQVRIKVSPAEISIFSIRKACKTSGISCSTQKLVEAHRKIGYSNIEDKKILRNLRRISFVTGIKYETLAPRDYVFNLTNCLISDEGTRSRLANIANPLDYIERRIYSRSLEILADVRGEGRNNVMVAAAAICVADRIEGGVLGSSIIAKTLHLDKYKVSLAIERILNQMREGGKVVKFRVNPAAEYRSQVFGEFARFGQRWRPDEGESRGDTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICN3</accession>
    <name>K0ICN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c22010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22010"/>
    <dbReference type="EnsemblBacteria" id="AFU59131">
        <property type="protein sequence ID" value="AFU59131"/>
        <property type="gene ID" value="Ngar_c22010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22010"/>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2199-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="385"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="595" mass="65680" checksum="C3D76303965303A9" modified="2012-11-28" version="1">MHVSSKRTFSKNSIALLVLTGAIAVSLSLASFQYSNFTANEILKIASDNVRSNARIQVNDLESVLVHRLDSVTSNLEVISKARSVQSNEFERGQALFNAAQDSTANLTNFYMWLDGEGRIVWLSNINQTAYEQFRGTDLSQRAYFIEARNRQDGAYYSSAIDSNDNITRIYISYPILGTSGEFIGAAVAGIRVDTFGMSLQDQLSPETQSSVGMTDRSGMILYSESSELIGKDVFGPEFQSLLLPGLKDSFNRFLTESLQGQSGIQDFTVGNATYSIAYEPIIIGGEQFGTLYVVTPHQFADNVRALADQQRDFSSVMVIVIGVAAIGVAALVLAWNSRLERVVAARTSELKLKTDELKRSYDSLAAANEQLKVHDRLQKEFINVAAHELRTPTQAILGYAELLQMSPEDRDEMIRAIYRNSVRLQRLTSDILDVTRIESEAFKIDKERFNLKDVILGAIQDAKNQLPDGRIEFVYEPTDIYVHADRGRITQVISNLLDNAAKFTKRGTITVSTENKNGQAVVSVQDTGSGIDSDIMPRLFSKFASKSDKGTGLGLFISRSIIEAHDGRIWCTNNSDGKGATFAFSLPLSSSSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICS5</accession>
    <name>K0ICS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC uptake transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c05060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05060"/>
    <dbReference type="EnsemblBacteria" id="AFU57450">
        <property type="protein sequence ID" value="AFU57450"/>
        <property type="gene ID" value="Ngar_c05060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05060"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="AFIETRE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-504-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="268" mass="29954" checksum="CA30EE57BCF99578" modified="2012-11-28" version="1">MAKLEARNIGKQFMAVQGSNTKLITAVKGINLSIEDGQFVCLVGPSGCGKTTFLNILAGLDKPTEGEVILDGHPVNETGPDRVMVFQENALFPWLKVVDNVEFGLKMAGIEKSKRHERAMHYLEMMQLTKFADAYTYQLSGGMKQRVAIARALAIDPEVLLMDEPFAALDSQTRDLLLVELQLIWARTKKTIAFITHNILESVVLGDKVVVFTKRPGTVKKEITVNYRRPRLPEDENLQPYYRQVIDAMKGEIISDKDDNDNNSDGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID36</accession>
    <name>K0ID36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59296">
        <property type="protein sequence ID" value="AFU59296"/>
        <property type="gene ID" value="Ngar_c23710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23710"/>
    <dbReference type="HOGENOM" id="CLU_2420146_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2369-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="9905" checksum="1A26871EBE5DABFC" modified="2012-11-28" version="1">MRDSSDNLYTMVGKFLSEGNAVVYAVGGSGGRGGIRIPRNQLVNRMYSKIRQSGLIGDVEDYIRTGALKIMDVREIYSSDLVGNTATMLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDH5</accession>
    <name>K0IDH5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25340"/>
    <dbReference type="EnsemblBacteria" id="AFU59456">
        <property type="protein sequence ID" value="AFU59456"/>
        <property type="gene ID" value="Ngar_c25340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25340"/>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OMA" id="WFIVVEC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2533-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="19691" checksum="FCF44BCC2D86EADB" modified="2012-11-28" version="1">MKRNWLLDDIFDGIATKLDVRQFRPQDVLSEIKQSILEAARLMGSGINTQHWWFIVVECKDQLKKLAEDSTSRQWVAEANFAIIVLTNPKHKFHMIDAGRCCRTTQLAAWNRGVALGLFADIKEDKLRNDFGIPKELNIAVVIGFGLSCRQVDRQEKGSRAAWRAGPLWKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDL7</accession>
    <name>K0IDL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25690"/>
    <dbReference type="EnsemblBacteria" id="AFU59491">
        <property type="protein sequence ID" value="AFU59491"/>
        <property type="gene ID" value="Ngar_c25690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25690"/>
    <dbReference type="HOGENOM" id="CLU_1375563_0_0_2"/>
    <dbReference type="OMA" id="LEWDCET"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2568-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="22300" checksum="3FBCF09C475EA163" modified="2012-11-28" version="1">MTVIQKSIEINAPVSEVFTYFARPEHMADQFPENMGLSVIPVEVKNGFGVGTIFRISGDFDGKKLEWDCETIDYVPMRKIVAKMIEGPFKSWQITVDFEELGEKKSRTGMTVEYDMPMGPLGSFMDKVKLKKIAERGMENGLYRVKALLEGTGSIPVYITLDAYRHILKEKEKLNCSVSEAIVKIIQQSQQQHTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDM0</accession>
    <name>K0IDM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative diacylglycerol kinase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57785">
        <property type="protein sequence ID" value="AFU57785"/>
        <property type="gene ID" value="Ngar_c08430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08430"/>
    <dbReference type="HOGENOM" id="CLU_2802394_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-841-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7202" checksum="13824E3A6ED157BE" modified="2012-11-28" version="1">MLVKSLDIPAGVVECCKNIASVNKSVKLDVIGVRATRKEDGSTTPMRIMLNAAEMGVAAEIIDRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDP4</accession>
    <name>K0IDP4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59516">
        <property type="protein sequence ID" value="AFU59516"/>
        <property type="gene ID" value="Ngar_c25940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2566"/>
    <dbReference type="HOGENOM" id="CLU_202921_0_0_2"/>
    <dbReference type="OMA" id="DWVTSGQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2594-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8954" checksum="FECCFC6BC16EEFDC" modified="2012-11-28" version="1">MSASLVMARSFDDWWRTVPADLKTKARKGDEANKPLLNQINYVLLHLHLAGKHDLKPTHEELKDWLHSGQVDVLRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDS9</accession>
    <name>K0IDS9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26190"/>
    <dbReference type="EnsemblBacteria" id="AFU59541">
        <property type="protein sequence ID" value="AFU59541"/>
        <property type="gene ID" value="Ngar_c26190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2591"/>
    <dbReference type="HOGENOM" id="CLU_041799_2_1_2"/>
    <dbReference type="OMA" id="LWDGIRN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2619-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="15365" checksum="31B3CE768A98933A" modified="2012-11-28" version="1">MAYWLFKQEPSTYNYSQLEKDGKTIWDGVANNLALKHLRSVKKGDRALFYHTGEEKQVVGIMEITSDPYPDPKDRSLVVVDVRPAGRLAKPVTLDAIKRDSAFSDWELVRISRLSVMPVPDRLWDRIMKMSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDT4</accession>
    <name>K0IDT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57890">
        <property type="protein sequence ID" value="AFU57890"/>
        <property type="gene ID" value="Ngar_c09480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09480"/>
    <dbReference type="HOGENOM" id="CLU_1248316_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-946-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="25487" checksum="5AABDB98FBE119D6" modified="2012-11-28" version="1">MNEGYYHVQITKKSGQRAYEIDLAESQLLERIVNPIKNKSDFMCGHSLLNRSEIENVRITRTLEHSSKLKWAKFNTGMDRWIGNVDARPFEYYVVRSGEDVTTNYLDSSALQERTDESVSKSESKRYSELFHDTQFSIDEKLCFVLMPFNEEYKFVYNDIIKPVVNALGLEAKRADDIFEPAPIIQGIWEHINKANVIIADLSGRNPNVFYEVGLSHALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDU3</accession>
    <name>K0IDU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57905">
        <property type="protein sequence ID" value="AFU57905"/>
        <property type="gene ID" value="Ngar_c09630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09630"/>
    <dbReference type="HOGENOM" id="CLU_1567208_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-961-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="18920" checksum="D8DC2D138BE75421" modified="2012-11-28" version="1">MMLEQRDYSQLFRELEYYRNRCSELEAENKQLKEELHALKSTVSAVVARSVDARQAARKKKRHKKPGQKKGHAGKSRKRPEHIDARVTIDQTSCRKCGSALSERPTDSYSRVVTDIVPARPVVRVHSQKEVLLLLQKAGVSTCTGSTPKRGVRAQADAPDSVAKAAGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEG3</accession>
    <name>K0IEG3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58160">
        <property type="protein sequence ID" value="AFU58160"/>
        <property type="gene ID" value="Ngar_c12200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12200"/>
    <dbReference type="HOGENOM" id="CLU_1127114_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1218-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="22354" checksum="2CFB38D385D84199" modified="2012-11-28" version="1">MAQNLERLIDAGEGKGFEVEHDVDYGAGPIDVVWNINVHPALPNIKCGFVRLEAEEGGSQDTEDNQLSLRKIEEAAVRGLRSGLDKVYLVAENEEMARSVSGKIEWLASHGSLLRLDAVSLGLAPNQIESAVITPSQKRVPEGEKIRKRAMREREAKIEKYSRPKGERRKRESPLKKALREERIDRNNRPRDQKPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEJ0</accession>
    <name>K0IEJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59766">
        <property type="protein sequence ID" value="AFU59766"/>
        <property type="gene ID" value="Ngar_c28460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28460"/>
    <dbReference type="HOGENOM" id="CLU_2581538_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2846-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9052" checksum="612DD152DFE22825" modified="2012-11-28" version="1">MMPRNGYNYNLLRISLERALSVLGESSKQILLFYMAEHCGISFDRKCSLAEIESALRSVLGSGSAIITKRMYKELQSMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP9</accession>
    <name>K0IEP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59831">
        <property type="protein sequence ID" value="AFU59831"/>
        <property type="gene ID" value="Ngar_c29120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29120"/>
    <dbReference type="HOGENOM" id="CLU_714991_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2912-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="386" mass="44719" checksum="7AED10F4993DCED8" modified="2012-11-28" version="1">MHFLVATFRLNIMERWEQFWLNSEKNMEVAHLLRNQLDKNYVGLSLYHAQQALEMAVKACMFKFELERYLRLKESSDSKSEIVFVRDRSRVGDPVHTHFPVAELIYTSFGFIESQAKKVAKTGNLDFDQSLNDIVDAAKTVREFVDYVDPKGSKVDSKEALHRKKELWKLSLQMDIEDQKIKDFISKLRAAGQPGGTSTNFQLSSVQFVKNLVAKLTLVLEKTGNERHLIYAKGRAQDILKKAGLPPDLVFLFMHDRNSGAYDAAIEDLVREQGMWPILIRLFSPEGVIKQVQKLRYDTKVANIKGARMLFPFFRINLIWMGYIASIAYVMLFMFPHEEFGRYLQPIDARTSEDIYLERREKANILIDECDKACQTIKLILKTMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEQ3</accession>
    <name>K0IEQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59836">
        <property type="protein sequence ID" value="AFU59836"/>
        <property type="gene ID" value="Ngar_c29170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29170"/>
    <dbReference type="HOGENOM" id="CLU_1352150_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2917-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="23867" checksum="F6C6F62441178A52" modified="2012-11-28" version="1">MESKGTAFDITSDFIEEQRKAADKIQGTNIVKPSKFSPYTRAEREKRRKEVARLHFEKGMPGIRIAEAMKVDKNTIYADLKAIYRELARPGYSTAEAYDRFYVRLEMQRARLEEYLSKESDVQTKLMIERQLTDIESRLLKADERIYDNANKIRNEVAEHINKYCEENKLDYRVLNLQELLKVSSEGWNSFMTVLRKERIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IET8</accession>
    <name>K0IET8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03310</name>
        <name evidence="3" type="ordered locus">Ngar_c03600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Enrichment culture Ga9.2</strain>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57279">
        <property type="protein sequence ID" value="AFU57279"/>
        <property type="gene ID" value="Ngar_c03310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57308">
        <property type="protein sequence ID" value="AFU57308"/>
        <property type="gene ID" value="Ngar_c03600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03310"/>
    <dbReference type="KEGG" id="nga:Ngar_c03600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.320"/>
    <dbReference type="HOGENOM" id="CLU_3094224_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-331-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5652" checksum="2B317E910CB20AFA" modified="2012-11-28" version="1">MNKAKEVEEWFRRNLIPVLFIALGMVLVAVFAGTKAGRQVVKKAVGAPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEV6</accession>
    <name>K0IEV6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="2 9">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cas4</name>
        <name evidence="11" type="ordered locus">Ngar_c03800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03800"/>
    <dbReference type="EnsemblBacteria" id="AFU57328">
        <property type="protein sequence ID" value="AFU57328"/>
        <property type="gene ID" value="Ngar_c03800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03800"/>
    <dbReference type="HOGENOM" id="CLU_102055_2_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="10">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="216" mass="25293" checksum="98B5DB7C94DAD7C6" modified="2012-11-28" version="1">MSSSFNDEYSFNDAAENSISVTDIKHYFYCPKIIYFDKVMHADAVLSSQQEDAKKTHKEKEKKDKRRKTMFYEEQFPNCVKLFNIHMYSESLRVEGVVDCMIVNGNERIPVDYKRMFSKKGEAWTDHRFQLTAYALLLEEQYSTIVRRGFVYYLPEDKAVEVKITESMKTYLKKTVKAIQNVIESGEEPVARIPKSRCTGGCGYLWICGGIWNRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEX4</accession>
    <name>K0IEX4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2070 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c13830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13830"/>
    <dbReference type="EnsemblBacteria" id="AFU58320">
        <property type="protein sequence ID" value="AFU58320"/>
        <property type="gene ID" value="Ngar_c13830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13830"/>
    <dbReference type="HOGENOM" id="CLU_456074_0_0_2"/>
    <dbReference type="OMA" id="PSTHDFN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1381-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019204">
        <property type="entry name" value="DUF2070_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09843">
        <property type="entry name" value="DUF2070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="14"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="585" mass="62697" checksum="A0D01850C7AB06ED" modified="2012-11-28" version="1">MFAPGQDDVSNIHRRWSFTTIGPSSSKVSYAIWLGCAIAIVVVSHLYHLQADTEGLAVYLPLGIVALVGSHFLDYMALHGTPVNKLSKVAHVSAFANGLWALTVFLGVAADLVFAKPPSGMDYIVAGMLLAVGLRIGIFTSVFGASTGRATAVSFIQPLIFLFAFVPPLYHSLDTFSSAGVAFGAAFVALGIVWTVLADRAGRPGIKSTFGVLQAFIAAWTENRVDKMEEFTEAKAHDDVVSTKIIRFGSLAAIVLPDIHPGPFSMVGGSNLPYVLYETFNKSALVMHSVSDHSLNIPSKREVDRYVKELGKRTVVERGSTCSVPVQIKITNSTCTGIAFGNTAVVMLSLSPKGMEDIPQSVRTELESFGIGLGFSDVLVVDCHNAMGKHLDDSDRDDLVMSAKQCLDRMKNQPQHEFNIGFAGLGDISHQPDLEGELGQAGLAVLVIGVGGKNYAIGWADSNNMNNGLRDRVISKASGDVTTILELCSSDTHSTSGKRTREGYFALGTTTNADDIAEAYIQLCAKAAERAAKSTFELSVAQSTIKVMGQKQFEDYSTALDRSMNVTKIFVAITVATYIAMLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEX8</accession>
    <name>K0IEX8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58325">
        <property type="protein sequence ID" value="AFU58325"/>
        <property type="gene ID" value="Ngar_c13880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13880"/>
    <dbReference type="HOGENOM" id="CLU_067489_0_0_2"/>
    <dbReference type="OMA" id="WHFLFDP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1386-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="368" mass="39026" checksum="F3F88C62C1E548ED" modified="2012-11-28" version="1">MRFIISAEKIRIINQMAASPLVKYFATVLSGIIAALLISSLVLQAYAADLSASLVPQTDNAKVSYIGVKTVTIRYPEGSSLAQELNGKNERIQFELNGTTSSQDESGMSEVISAVNRAFIAAQSPVQVEQAAIIYTAVLRGGPQSTLISYRVDLQPTLERYLITTDSSGDIIDLEWRGIVVQEPLVVTAPDIGRININYPIGLLEALYPSIAEKLANSPASTVLEDPILNFDDFNAPMGSWHRLFDPVGTYGTSVGLDTGGAKALSVYSLGESSLREGAHTETEKDADATIDGAQVNVHSTTPPPSGQITIAGYANHQENEGAEFAIVTAEAPAGAQTSTGGFPIQVLLVLGGMMGAVAIFVLLKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEZ6</accession>
    <name>K0IEZ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59931">
        <property type="protein sequence ID" value="AFU59931"/>
        <property type="gene ID" value="Ngar_c30130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30130"/>
    <dbReference type="HOGENOM" id="CLU_2875214_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3013-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7045" checksum="7F686C730FF0B68F" modified="2012-11-28" version="1">MDVIVDDIAERAAQLGSKAIATLEEFKQLSEIKEHPNQYPDANKMLSNLFADHEKLSAAQEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF01</accession>
    <name>K0IF01_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl12p</name>
        <name evidence="4" type="synonym">rpl12</name>
        <name evidence="6" type="ordered locus">Ngar_c30200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30200"/>
    <dbReference type="EnsemblBacteria" id="AFU59936">
        <property type="protein sequence ID" value="AFU59936"/>
        <property type="gene ID" value="Ngar_c30200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30200"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2991"/>
    <dbReference type="HOGENOM" id="CLU_114656_2_0_2"/>
    <dbReference type="OMA" id="EYIYAAM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="10526" checksum="50AB8E0BB0EA0267" modified="2012-11-28" version="1">MEYVYAALLLHKLKQNITEDSVKNVVKAAGVAPDDVRVKALVAALSEVNIEEALKAAPVAVAAAAPTAGAAPAAGGGAAAAKAEEKKEEKKEEEALEGLSSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF95</accession>
    <name>K0IF95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60041">
        <property type="protein sequence ID" value="AFU60041"/>
        <property type="gene ID" value="Ngar_c31250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31250"/>
    <dbReference type="HOGENOM" id="CLU_3178706_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3125-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5300" checksum="27220B84889ABEB3" modified="2012-11-28" version="1">MASRAWFIITTQIASLDKKENKLFKIMVLKNDMQPRRASVVVPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFE6</accession>
    <name>K0IFE6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58535">
        <property type="protein sequence ID" value="AFU58535"/>
        <property type="gene ID" value="Ngar_c16020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16020"/>
    <dbReference type="HOGENOM" id="CLU_2177959_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1600-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12468" checksum="991DA9BA36DCDC8E" modified="2012-11-28" version="1">MVADLKFKGGVGKRGLMFVPYYGRSRAFIANYSSWRKYSREGKIAEVASSLLSHETLHIAINKFSLSASANLDNLFGRSNSWERYHHGLGDLDRVHRHSTGKYARKHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFH9</accession>
    <name>K0IFH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60121">
        <property type="protein sequence ID" value="AFU60121"/>
        <property type="gene ID" value="Ngar_c32050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32050"/>
    <dbReference type="HOGENOM" id="CLU_157001_0_0_2"/>
    <dbReference type="OMA" id="VYANIYS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3205-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11254" checksum="E375C8C18AD7F8F2" modified="2012-11-28" version="1">MALLMDISSIISMANVAILVALLAVYANIYSKTRATFTVGLVVFASMLMLHNGIAVYGYFAMAPLYSDDLLPYFVGIHIAELAGLVALLKVTVWPEGVKTTPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFN1</accession>
    <name>K0IFN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57638">
        <property type="protein sequence ID" value="AFU57638"/>
        <property type="gene ID" value="Ngar_c06950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06950"/>
    <dbReference type="HOGENOM" id="CLU_194244_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-693-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9950" checksum="A1CC7469C36972B2" modified="2012-11-28" version="1">MAEGTAASINKGTNQPMDNCCFDIMTQTEKKADFLYHAADRYIQDAQAANRPELAHLWNMIKQDEQRHLDMLKRELAKDVQEGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFQ1</accession>
    <name>K0IFQ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribB</name>
        <name evidence="4" type="ordered locus">Ngar_c32660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32660"/>
    <dbReference type="EnsemblBacteria" id="AFU60181">
        <property type="protein sequence ID" value="AFU60181"/>
        <property type="gene ID" value="Ngar_c32660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32660"/>
    <dbReference type="HOGENOM" id="CLU_020273_3_2_2"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="226" mass="24600" checksum="5B108E65F948A3C7" modified="2012-11-28" version="1">MSLTEAIAALKAGKFVLVHDGKGRENEIDMVVAAEYVKPHHIVTMRKDAGGLVCLAIANNITTKLGLVYMHDMIASMGKVNPVFSKLTEGRAAYGDKPSFSISVNHRSTYTGITDHDRALTISKMAQVCKKIDDGGVDDFAKNFRAPGHVPILIASKRLLQDRMGHTELCVYMMQLAGLTPAVALCEMMDSDTHKALSIEDAQEYADKFNIPLIDASELKAHAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFZ8</accession>
    <name>K0IFZ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S3ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="3" type="ordered locus">Ngar_c17770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17770"/>
    <dbReference type="EnsemblBacteria" id="AFU58710">
        <property type="protein sequence ID" value="AFU58710"/>
        <property type="gene ID" value="Ngar_c17770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17770"/>
    <dbReference type="HOGENOM" id="CLU_062507_1_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="26307" checksum="6390899E55DEF465" modified="2012-11-28" version="1">MVKGAKKGGRVRDKWRDKQWVVVNKPYGFEPQVPVNYVPITDVEHAKGRTIENTLHDMMKGNPDQSMDQHQIKVFIQIDKINDGIASTIFKGHEYAKEFLRSLIRRGSSMIMFTHDYTTMDGHTFRVAVVAFTQRRVNSSKKHEIRMVAHKILSERIPQLTVDRFVQEVTGSKRGDIPRETNSKLGAEILNEAKKITVIRHIGIKKTKLISTPESRAIEEAKPVEAAPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG17</accession>
    <name>K0IG17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)alamin adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobO</name>
        <name evidence="1" type="ordered locus">Ngar_c17970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17970"/>
    <dbReference type="EnsemblBacteria" id="AFU58730">
        <property type="protein sequence ID" value="AFU58730"/>
        <property type="gene ID" value="Ngar_c17970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1776"/>
    <dbReference type="HOGENOM" id="CLU_088595_2_0_2"/>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="177" mass="19221" checksum="1A4F385A7EAEC735" modified="2012-11-28" version="1">MSERGLVIVYTGKGKGKTTAALGIVLRAVGHGYKVCMIQFIKGEWYYGELASSKRLEPEFELIAAGKGFVGIIDDDHPIGDHQNAAKQAVSLAKEKLASGAYDIMILDEINYAAKLNLISEQDILDIIAAKPEKTSLVLTGNYAPDPVIATADLVTEMKEIKHPYQKGIKAKKGIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGF1</accession>
    <name>K0IGF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58880">
        <property type="protein sequence ID" value="AFU58880"/>
        <property type="gene ID" value="Ngar_c19480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19480"/>
    <dbReference type="HOGENOM" id="CLU_2044487_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1946-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13290" checksum="1076F5C87CADBBF9" modified="2012-11-28" version="1">MEKELIDEVRARLHAMIDAAIDEYSAKLNKSAGQQIPTPDGLDIDKLPWQKSKHGQYEYLFPSQVPDNLKTALKNGKAQIRDCILYLTKQGSVRRYRITSNKQTANSSAASAGGGGDVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGL0</accession>
    <name>K0IGL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20130"/>
    <dbReference type="EnsemblBacteria" id="AFU58945">
        <property type="protein sequence ID" value="AFU58945"/>
        <property type="gene ID" value="Ngar_c20130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20130"/>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OMA" id="AKNLQPW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2011-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="20450" checksum="597557D36AD15729" modified="2012-11-28" version="1">MCAGYGQMDMKEQFFWLLKQRRSVRAFDRERKLDDSVLDAILEGCDLAPSSGGLQSFEIYMVENDEKKRRLVAAARDQGFVAEAPLLLVFCANPSRSIHKFGERSQLFSVQDATIAAAYAQLTVYALGLTTVWTGAFDEKRVSEILGLPEGHRPVAMLPIGYPSEAPKEKTTRGSQDLFHKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM0</accession>
    <name>K0IGM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58965">
        <property type="protein sequence ID" value="AFU58965"/>
        <property type="gene ID" value="Ngar_c20330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2010"/>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2031-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="17451" checksum="A8F556DA1CA8E5C2" modified="2012-11-28" version="1">MLCEASIMVIETRRIYSMKKHATVGSFNIFVDRLWARGMKKEEADIDLWLRDIAPSDELRKWFGHDPRKWNEFKERYFKELDGKKELVEPILQKFILTLRYYCFMVPRMRNSTMQWHSRNICLKSWRNKVLSNLHLVDSHRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGP2</accession>
    <name>K0IGP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58995">
        <property type="protein sequence ID" value="AFU58995"/>
        <property type="gene ID" value="Ngar_c20630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20630"/>
    <dbReference type="HOGENOM" id="CLU_1943926_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2061-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14768" checksum="4E2026B5787029CF" modified="2012-11-28" version="1">METTLVKRMAASTKNHVEDELKKIKVKILEEKLPIWLDSSFTLTQRLDERLDNNYWSASYFNALKTLKALQDRDVVEVKRFSELCSLRVTGASPTEDGDVPLIEGNNIRPNVVYPLFEKFTSMSENEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH77</accession>
    <name>K0IH77_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 18" type="primary">uvrB</name>
        <name evidence="18" type="ordered locus">Ngar_c12630</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12630"/>
    <dbReference type="EnsemblBacteria" id="AFU58203">
        <property type="protein sequence ID" value="AFU58203"/>
        <property type="gene ID" value="Ngar_c12630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1209"/>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_2"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:excinuclease ABC activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UvrB"/>
    </dbReference>
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        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
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        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="429"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="614"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFU58203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="659" mass="75432" checksum="A248EB4E59C55914" modified="2012-11-28" version="1">MLTSSRSFALAKDAFPPSGDQPEAIEQLVRGVQKGGRQTLLGVTGSGKTYTIANVIARTNKNTLVISHNKTLAAQLYAEFKEFFPENNVGYFVSFYDYYQPESYIPQTDTYIEKDTEVNEKIEKMRLEATAMLMSGEPTIIVSTVSCIYSLGSPKEWEKSAITLTKGMEIDRKILIHNLIEARYERNDMSLMPGNFRAKGDTIDIIPGYSDDIIRVSVFGDEIERISIHDHVSMKKLRDVNAVKIFPAKHYITDDDSRNSALESIKRELENWLPNLPSELERQRLAQRTKYDLEMIEELGYCSGIENYSRHLDGRAPGQPPFCLLDFFGDDFLLVIDESHVTLPQLHGMYNGDHTRKKMLIDYGFRLPSSYDNRPLKFEEFEKYLRNVIFVSATPGPYELKSSWQVAEQLVRPTGLVDPKVEIRPTKNQMEDLIKEIKNRAKKNQRTLVTTLTKRMAEDLAEFLAKNEVRVRYLHSEIEGLERTQLIRQLRLGEFDALVGINLLREGLDIPEVSLVAILDADKEGFLRNTTSLIQTFGRAARNLDGAVIMYSDHSTESMKQAIEETERRRKKQLEYNKKHKIKPRTIVKPIPESTKEIGDMSVETKSMTRQDLVKLAVETEATMKRFAEELDFEKAIMFREKLSKIRKALGEPALAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHC9</accession>
    <name>K0IHC9_NITGG</name>
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        <submittedName>
            <fullName evidence="3">Putative stress response protein YsnF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ysnF</name>
        <name evidence="3" type="ordered locus">Ngar_c02190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57167">
        <property type="protein sequence ID" value="AFU57167"/>
        <property type="gene ID" value="Ngar_c02190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02190"/>
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    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02271">
        <property type="entry name" value="TIGR02271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2382" evidence="2">
        <location>
            <begin position="103"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="219" mass="25116" checksum="33CBB75530ACBFC0" modified="2012-11-28" version="1">MANTESIAWDDVVKKEARGAVDDSDFGEVQEIGQHYVLTQKGVMKKEKFYVPKYLVQGYDGKTLWFDASEDQLQGWRRDTAPSYDEYSSFRKPEAPKDIETRIPVIEERLQVSKRESTDEATITKRPVTENKTVEVPVTHEELTVERRPATDTTQAEGPVSSDTEIKVPLRREEVEVTKKPYVKEEVVIKKEPVTETQTVSDTVTSEQVDVEGKKRRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE8</accession>
    <name>K0IHE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57197">
        <property type="protein sequence ID" value="AFU57197"/>
        <property type="gene ID" value="Ngar_c02490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02490"/>
    <dbReference type="HOGENOM" id="CLU_2067889_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-249-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="14207" checksum="577B8473D8E9AD15" modified="2012-11-28" version="1">MSDAATREMDWYLRDHLYRQSNTGKAAFRRESLPSEMATLYLRYRNADLQQLSQLMVPVIDNLVARNVLEQQDGNELRLAGRLTRLQCAKCFYINYLAEAEQRACLRCQHIELHDFPKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHH4</accession>
    <name>K0IHH4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57252">
        <property type="protein sequence ID" value="AFU57252"/>
        <property type="gene ID" value="Ngar_c03040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03040"/>
    <dbReference type="HOGENOM" id="CLU_3113189_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-304-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5658" checksum="02705F87D19B96D3" modified="2012-11-28" version="1">MELWVIKMAPARDIPDTGIPDHAYVETLLPCTIRLSWASFSSYLSCFTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHK0</accession>
    <name>K0IHK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA mutase, large subunit</fullName>
            <ecNumber evidence="3">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mut</name>
        <name evidence="3" type="ordered locus">Ngar_c25020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.2" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25020"/>
    <dbReference type="EnsemblBacteria" id="AFU59425">
        <property type="protein sequence ID" value="AFU59425"/>
        <property type="gene ID" value="Ngar_c25020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25020"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2481"/>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_2"/>
    <dbReference type="OMA" id="PWGGSAY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="2">
        <location>
            <begin position="16"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="539" mass="61266" checksum="88785C1D69C7CAFC" modified="2012-11-28" version="1">MVDMVAKPAKPTENFKTDSNIPVKRVYNRKDLAKYNSSRRDEEPGKYPFTRGLYPNMYRERVWTMRQYSGFGSAEETNKRFKFLLDHGQTGLSLAFDLPTQTGRDSDDPQSEGEVGRTGVAISSIKDMMTCFDGIPLDKVSTSMTINSTASTLLSLYITVAESQSVPPDQLRGTTQNDILKEYIARNTYIYPPKPSMRLIGDMIEYCSKKVPQWYPISISGYHMREAGCNAVQELAFTFANAIEYIETCISRGMKVDDFAPRLSFFFCCTMEFFEEIAKFRAARRIYAKIMKERFRAKDPKSMHLRFHVQTSGESLTAQQVDNNIVRVTTEALAAVLGGCQSLHTNSRDEALALPTEESVKVALRTQQIIASETGVVKTVDPMAGSYYVEYLTGKIEEEVNKYLKKIDRMGGAMVAVEKGFFQEEIRNNAYQLKKEIDENKRVIVGVNKYQDAHDVEPKLNKIDQEIENRQIARLKELKSSRDRTKVDQALSQLQKAAEKDDENLMPHIINAVKNYSTLGEISSTLRTVFGRYEPKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP4</accession>
    <name>K0IHP4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59460">
        <property type="protein sequence ID" value="AFU59460"/>
        <property type="gene ID" value="Ngar_c25380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25380"/>
    <dbReference type="HOGENOM" id="CLU_3038873_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2537-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6504" checksum="0CC08813B9A59A77" modified="2012-11-28" version="1">MCNCPKVTFYEVEFKTVGMKVVANHKNCGDFLNDDQFSAFEKELTKYWGFEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR6</accession>
    <name>K0IHR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative UPF0126 membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c04300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04300"/>
    <dbReference type="EnsemblBacteria" id="AFU57377">
        <property type="protein sequence ID" value="AFU57377"/>
        <property type="gene ID" value="Ngar_c04300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04300"/>
    <dbReference type="HOGENOM" id="CLU_064906_2_1_2"/>
    <dbReference type="OMA" id="RAPRAWN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-429-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="7">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="7">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="213" mass="22784" checksum="E32D1963FC9B0B28" modified="2012-11-28" version="1">MIIVLSDVLPVPLLIQALDLFGTMAFAVTGAFKAIEHKSDIVGVIILATITGVAGGVMRDLLFGRIPPTAIVNPLYLIITVATGVVMFFLYRALKKHWNLFLKFDAIGLGVFTVIGATVAYNLFGLNFLAMVFAGLFTAIGGGILRDVFVNEVPIVFIKELYASASFIGIVMFFGLLAAGADLNVAAIPSIIAATSLRLLAMRYNWNLPASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHW3</accession>
    <name>K0IHW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57487">
        <property type="protein sequence ID" value="AFU57487"/>
        <property type="gene ID" value="Ngar_c05440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05440"/>
    <dbReference type="HOGENOM" id="CLU_703250_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-542-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="235"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="392" mass="43119" checksum="51D996A9366386D6" modified="2012-11-28" version="1">MGQSGLQWDPADYVSVDRLNQKDIFTGTATQIDAIKTTYAGMRVYCTQAGGINNLEADVLYIRNSQNTAWIKIARMNQEANPKQVTFSSPDSLDWTDPVSVTVSSGGSETVVCNPNAPDNYYSMSANYNQREAERITDTSLRNKALVSVKWYLAKGGSPTGNVECRIRKVSDDSIVATATNPIAASSLSESSYTRHTFNFPANTLTPNEDCRIAVEYPSGDASNYIKVGVHTGSGNTYAGGHREGYSGAWNITDTSHDFNIEIIFGSGANIKDNNTSTKWTSLNEANPWAYVEVASTSKPTGAIRVFWGNSNETPTNYKVQHSNNASSWTDLLTRNVKPPSNQWTTYEFNIVDCRYVRVLAQETLAMSIYEVDIYKQEAAQALADHSHALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX0</accession>
    <name>K0IHX0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57497">
        <property type="protein sequence ID" value="AFU57497"/>
        <property type="gene ID" value="Ngar_c05540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05540"/>
    <dbReference type="HOGENOM" id="CLU_1656925_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-552-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="159" mass="17498" checksum="3A1518C6B7976309" modified="2012-11-28" version="1">MYAKLCNIEILSSYIKDVSVGDMLTVQALITNPLDWQHFYEKILTIKRGDKTDFTVVTGEGDRLVGTGDIVEVDKWSNSGHYGFKIKIDVKRQKSLTDRRIRGPGRTAKPAAEKPPAEPAEAEAPQFAPLAAAATTLVTPQDIASFREMLKGSITMDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ7</accession>
    <name>K0IHZ7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ureD</name>
        <name evidence="4" type="ordered locus">Ngar_c06190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06190"/>
    <dbReference type="EnsemblBacteria" id="AFU57562">
        <property type="protein sequence ID" value="AFU57562"/>
        <property type="gene ID" value="Ngar_c06190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.595"/>
    <dbReference type="HOGENOM" id="CLU_056339_1_0_2"/>
    <dbReference type="OMA" id="CQHIIVH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="326" mass="36748" checksum="02F2B27247C30216" modified="2012-11-28" version="1">MSRHPKPLLDAEKSLEDVNKLEYYVPSSIPPEVLAYASTLDQLGVGKAGKLGGLILKLEKDEVSGKTAVKQQYSRVPLYTQRALYLEEALPSMAYMYIISPSGGILQGDRYRMDITLRREAMAHLTTQGATRIYRMEKNFATQIVNITVEQGCYLEYIPDQIIPYRNSRFYQIANLHVHDNATLVYSEMVTPGRVAGGEHFDYDICYMKTVAKNQKERLRYYDVAILEPKKRNMGAFGVLEKLDVFGTVYVLTETEKVLELYEEISREIRRVGGFSGGASILPDNNGIIIRLLGSTASEVRSVIFEVVRSVRKVVLNAPFSGIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II41</accession>
    <name>K0II41_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57647">
        <property type="protein sequence ID" value="AFU57647"/>
        <property type="gene ID" value="Ngar_c07040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07040"/>
    <dbReference type="HOGENOM" id="CLU_2679059_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-702-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="7756" checksum="389A10927EEB0599" modified="2012-11-28" version="1">MEILAISCGFVLSQNAPRISPSSPQNIAVIKALAILKQVTKSIGAVISSGFGGIPKYALIITVAYRAGIMTFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID7</accession>
    <name>K0IID7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c18200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58753">
        <property type="protein sequence ID" value="AFU58753"/>
        <property type="gene ID" value="Ngar_c18200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18200"/>
    <dbReference type="HOGENOM" id="CLU_2519878_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1818-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="2">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9913" checksum="D7645B536203649D" modified="2012-11-28" version="1">MAHKNQPSGTKRNAKKMMTINDKLVIYLNDALAIENVAIPRLQQRIKEVSLPEAKEQLKHHLEETREQQSRRATYFEPWRKGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG0</accession>
    <name>K0IIG0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18660"/>
    <dbReference type="EnsemblBacteria" id="AFU58798">
        <property type="protein sequence ID" value="AFU58798"/>
        <property type="gene ID" value="Ngar_c18660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18660"/>
    <dbReference type="HOGENOM" id="CLU_3418663_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1864-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="25" mass="2686" checksum="1E9F5ECA0D0E9D24" modified="2012-11-28" version="1">MSGRGPDVLTNIDGLKPLVRDEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL7</accession>
    <name>K0IIL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59755">
        <property type="protein sequence ID" value="AFU59755"/>
        <property type="gene ID" value="Ngar_c28350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28350"/>
    <dbReference type="HOGENOM" id="CLU_120323_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2835-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="17451" checksum="969A558ED5B8B1B6" modified="2012-11-28" version="1">MFSSGPNIRKIQFWSDMQGKEFAVRLSSDYDFRAVSNPSVKYTKLVEEAGYFSDMDYDWNFLLEHWMGVKNGSVRLLDDDGRGGRRPLRPAAFDLPDVDNDVSAVKKPNGRGAKREKPKPLLKCRYCMLSYNSEKERHEHEVTWHAEKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS9</accession>
    <name>K0IIS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58017">
        <property type="protein sequence ID" value="AFU58017"/>
        <property type="gene ID" value="Ngar_c10750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10750"/>
    <dbReference type="HOGENOM" id="CLU_1987690_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1073-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="14612" checksum="E0417E2A006F8D44" modified="2012-11-28" version="1">MTAQTEFSLIEKEAQIYLQTSEFLQKESGDTIVLGSKFSLYCDDIMESDEFQNKLSRKAGDKQKTDHDRLSEVLQSIMKYQRRLQRKQKQVLELPIKEKEMHPDAVIKILKDAKFEILRKCAGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY6</accession>
    <name>K0IIY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21270"/>
    <dbReference type="EnsemblBacteria" id="AFU59058">
        <property type="protein sequence ID" value="AFU59058"/>
        <property type="gene ID" value="Ngar_c21270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21270"/>
    <dbReference type="HOGENOM" id="CLU_932556_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2125-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="314" mass="37040" checksum="72BBBB8FB32F1456" modified="2012-11-28" version="1">MTATTANNNPDDPNLKTLLDFKKAVLEEQKAGEKKIEDINNQLESVKKQIDEERIQLDELRSKLKQVNEEKDAEYPKFMELRNSLIEAKNQMRSLDDKVSPAAAKSRKERSDMHNLQKTLEQIERDIQTKKLSKDEERKLVARSKEIATKLHALKMMHKKEDQYRTMSTQYDQLKDQVNRIFKLKEEYGNKIGKLKASLDTLINQRESLYEERRKFIHTVREANAKLEMIETQLNAIAFKKSRMQAAEHRHRKQKEMDERRVARQEAIQERAKRDKEYQERWNALKEAALKKMSSGEKLTFDEMKLIFGDSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ63</accession>
    <name>K0IJ63_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper-exporting P-type ATPase A</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">copA</name>
        <name evidence="7" type="ordered locus">Ngar_c22130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22130"/>
    <dbReference type="EnsemblBacteria" id="AFU59143">
        <property type="protein sequence ID" value="AFU59143"/>
        <property type="gene ID" value="Ngar_c22130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2194"/>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_2"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="719" mass="76937" checksum="A7B6120B22E71806" modified="2012-11-28" version="1">MAKDPVCGMFVEEKPDAIQHTVDGREYFFCSTQCLNEFTAPEKELRKLKMVTAASIALTIPVVILTYIMFLPIEVNNFILLALATPIQFWAGWRFYKGTWDAVKAKASNMDTLIAIGTTAAYLYSTVVTFLPTAFPFEGVYFETAAIIITLILIGRLLETRTKEKASSAVRKLLDLQPRMARIIKDGKEEEVPVEQVHEGDLFVVRPGERIPTDGTVTEGISSVDESAVTGESIPVDKSAGSEIIGATINKSGLLKARATKVGQDTVLSQIIALVEEARTGKAPMQKMADHVAKYFVPAVVAVAVSSALAWYFIGGIGLTFSLLAFVSVIIIACPCALGIATPAALMMGAGKGAENGILFKGGEHLEMARKVRTVVFDKTGTLTKGQPEVTDIITLSDVGEQELLRLAAIAESGSEHPLGQAVVRKAKEQGIVVAGPESFEAVSGHGLRAGYAGHTIMIGNRKMMADSGMVVAEQVSSAMGRLEIEGKTATLVSIDGRLSGVIAMADTVKENAREAIDALKQMGIEVIMLTGDNERTAKAIATKLGIDRVIAQVLPQQKEEVIAKLKSEGRVVAMVGDGINDAPALARADLGIAIGSGTDVAKETGGIILIKNDLRDVVSAFELGRKTVSKIKQNLFWAFAYNTGLIPVAAGALVPFFGAEMYGWLPFLAAGAMAMSSVSVVSNSLLLGRYRPSFAATKPRNEQIYTDKELKEVYTEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ79</accession>
    <name>K0IJ79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58287">
        <property type="protein sequence ID" value="AFU58287"/>
        <property type="gene ID" value="Ngar_c13490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13490"/>
    <dbReference type="HOGENOM" id="CLU_2730540_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1347-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7856" checksum="435AED322AF524F0" modified="2012-11-28" version="1">MSEEVELPSQFTHSVKLSDTAKGLRIDVHVYANDKITALKEAFALYQGAKEEAENRKIPLAPVELKGGRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ88</accession>
    <name>K0IJ88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58302">
        <property type="protein sequence ID" value="AFU58302"/>
        <property type="gene ID" value="Ngar_c13640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13640"/>
    <dbReference type="HOGENOM" id="CLU_2152688_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1362-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12665" checksum="C1C3D11453267D45" modified="2012-11-28" version="1">MSLIAEPTIEEQKNERRERSRTSQTKTGDEAITWREVKDRRNARLRAERAYFCPCSRGHYYSGPGSWKKAKEHAEVKGHPILRGYGTKKVKLMPWGQIADEEKGGGHKPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD3</accession>
    <name>K0IJD3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="17" type="ordered locus">Ngar_c23070</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23070"/>
    <dbReference type="EnsemblBacteria" id="AFU59233">
        <property type="protein sequence ID" value="AFU59233"/>
        <property type="gene ID" value="Ngar_c23070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2282"/>
    <dbReference type="HOGENOM" id="CLU_035113_2_2_2"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="187"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="335"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFU59233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="440" mass="48956" checksum="003966EB9D7AA712" modified="2012-11-28" version="1">MTTAAIKAAPSPTSSPTVAPVHIVNARVTYRNAPIHLLEKFTFKDIDGAHKAFLKKAGFEECVILQTCNRIEVFAASKNPDEGRLLEEWASAVGLPEKDFANVEVSRGREAVMHLMKLTSGLDSLVVGEDQILGQVRRAVEFSRSGRYASANLSLIFDRALKVGSRVRTATGINRGNVSIASVAVNLAEEYFDDLKSKTIMLIGTGEAASLVAKVLKKRNVNFMVTSRAPERARSFAETVAGTPIPFDSALEMLRKVDLIFTATVAPYRLLTFNRIENAMKNNRRQGMMIFDLSNPRTVDEKVATIHGVKLVNMDQIAELVGKNMRSRMKEISSAEKLIEDEMKSVDMMMKRMKAEPVVVSVFKNVDTIRERELKKALAMLGKKLGPEETKIVEQLSYAIVEGILSTPMNNLRKVTEEGESEELMKIVAKLFKYEEKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG0</accession>
    <name>K0IJG0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c14660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14660"/>
    <dbReference type="EnsemblBacteria" id="AFU58402">
        <property type="protein sequence ID" value="AFU58402"/>
        <property type="gene ID" value="Ngar_c14660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1430"/>
    <dbReference type="HOGENOM" id="CLU_069532_4_1_2"/>
    <dbReference type="OMA" id="EHVEMYL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1464-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17649" checksum="ED26D674861482F5" modified="2012-11-28" version="1">METAVAKKKPTGYEEELFVGTAESEHVEMYLKAIWYIRERGEEVKVSSIAKLLNVTQPSVVQMLRKLDGSQLVRYSKGSVEMTGEGERIGKQMMRNTRLLEVLMKDALKIEIDEEMVCGIEHHMKDIFTDALCTLLKHPRKCPHGHTIPRGKCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG6</accession>
    <name>K0IJG6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">leuD1</name>
        <name evidence="10" type="ordered locus">Ngar_c14760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14760"/>
    <dbReference type="EnsemblBacteria" id="AFU58412">
        <property type="protein sequence ID" value="AFU58412"/>
        <property type="gene ID" value="Ngar_c14760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1442"/>
    <dbReference type="HOGENOM" id="CLU_081378_0_3_2"/>
    <dbReference type="OMA" id="AFTTHTG"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="9">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="200" mass="23144" checksum="4256A4538533D7D6" modified="2012-11-28" version="1">MEPFTVLKSKATPLDRVNVDTDQIVPKQFLKLVNRTGFGKYLFYDWRFDRDGRPRSDFVLNNPKYSGRQILLARDNFGSGSSREHAAWAIFDYGFRAVIAPSFADIFYNNCFKNGILPVRLKSSEVDYLFKNEDLDIEIDLAEQLVVVAGSGRKMHFEIDEFRKKLLLEGLDSIGLTLQLEDHIARYERQNRMFFAPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM3</accession>
    <name>K0IJM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15430"/>
    <dbReference type="EnsemblBacteria" id="AFU58477">
        <property type="protein sequence ID" value="AFU58477"/>
        <property type="gene ID" value="Ngar_c15430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15430"/>
    <dbReference type="HOGENOM" id="CLU_835806_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1541-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="37829" checksum="F7F70966AC8B134D" modified="2012-11-28" version="1">MTGKNRKQSRRMSAVFGAIAMLAAAAALGITPTMLTTTSAFAWEDNNKYQAATVAEEVAKEAANNVQTPDKWDNNLQVGIHKVQDQIADAAQEISNGKQGANEEQESNEEYHQREEKENYPAEQQHEYPTREHEEEYPAEEQMEYPPHTEEYPVEEQQHAYPPRHEEEYPTEVKMEYPPHEEKEYQTQGAESEEHTIQQENNNNNNDDEGCSPNYWKNNLASWEVTRYSPDQKLSEVTDLGNAIPSEYDYTLLEALDTQNGGYDALAREFAAALLNSDHPNVKYALSTDKVIHNFEDGADPQIINSQEYYNDNDMQEQKNSLSDNNRAGCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT5</accession>
    <name>K0IJT5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c34350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34350"/>
    <dbReference type="EnsemblBacteria" id="AFU60350">
        <property type="protein sequence ID" value="AFU60350"/>
        <property type="gene ID" value="Ngar_c34350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34350"/>
    <dbReference type="HOGENOM" id="CLU_037162_14_4_2"/>
    <dbReference type="OMA" id="WRDYEQA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3436-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16919" checksum="CEC3972E60E10D82" modified="2012-11-28" version="1">MVDERSAGAVMFYMEGTAEPEYLLLHYTAGHWDFPKGNIEAGESEKQAAIREIREETGITDVEFLDSFRMKIEYKYRHGRRLVQKEVVLFLAQTRTRQVTISHEHIGFAWKKFDDAIQQLTYRNAKNLLLAAKEYLQQRSLAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT7</accession>
    <name>K0IJT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome oxidase assembly protein CtaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctaA2</name>
        <name evidence="6" type="ordered locus">Ngar_c25660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25660"/>
    <dbReference type="EnsemblBacteria" id="AFU59488">
        <property type="protein sequence ID" value="AFU59488"/>
        <property type="gene ID" value="Ngar_c25660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25660"/>
    <dbReference type="HOGENOM" id="CLU_1860763_0_0_2"/>
    <dbReference type="OMA" id="GANTIFN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="15656" checksum="E7DFA13B6F42185F" modified="2012-11-28" version="1">MLLQALSFSTLFVLFSLIFIGGYVSASGVGLTCPDWPLCPQGLLPHEDFIIEYIHRSVAATTGVLVVATMAFTLKSKAAPKSIKITSIIAAGAVIGQIALGAIVIVERLHAVLVTTHLGLGIVLFSMVLMTALYAYRLEGKKALAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJV6</accession>
    <name>K0IJV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58552">
        <property type="protein sequence ID" value="AFU58552"/>
        <property type="gene ID" value="Ngar_c16190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16190"/>
    <dbReference type="HOGENOM" id="CLU_2204200_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1617-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11988" checksum="E6D6541329BAE31D" modified="2012-11-28" version="1">MSYESDSSEFERMSTKKLAILFGLAFFGAFMVIQMIQGFPLAELFTRQTVTEEVEVSLKNKDVCIVEPADRQPKDIHQCPYNKGDMLVVTYYEGNTRLESHRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK20</accession>
    <name>K0IK20_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">nadE</name>
        <name evidence="8" type="ordered locus">Ngar_c35620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35620"/>
    <dbReference type="EnsemblBacteria" id="AFU60475">
        <property type="protein sequence ID" value="AFU60475"/>
        <property type="gene ID" value="Ngar_c35620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3566"/>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OMA" id="MVVQYAL"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="267" mass="29242" checksum="19C0B90318EAD119" modified="2012-11-28" version="1">MPAMLEKLVDQDFGKISGQIERSISGYVSKSSAKGLVVGLSGGLDSSVVLKLAANALLPSRVLGIVMPSDTTPKEDVDHAVKLAASFGVRYHVIDINPLLEKYAEVLPEDKKARGNLMARIRMNILYYYANINGYIVAGTSDKSELQIGYFTKFGDGAADILPIAGLYKTQVRALARHLGIPNEIVEKKSSPRLWLDHLAEQEIGMDYEVMDPILYLLVDRKMKPKAAAKRLGLPVSQVNRVKGMIETSLHKRSMPVAVSSINNSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK26</accession>
    <name>K0IK26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59578">
        <property type="protein sequence ID" value="AFU59578"/>
        <property type="gene ID" value="Ngar_c26570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26570"/>
    <dbReference type="HOGENOM" id="CLU_2968571_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2657-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6960" checksum="C57D1B6E9789777A" modified="2012-11-28" version="1">MLHKMIDRRRLDRVLRKKTCIICGRRPALDNEELCALCWPEIHHFAKHHKLVKTGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK36</accession>
    <name>K0IK36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58652">
        <property type="protein sequence ID" value="AFU58652"/>
        <property type="gene ID" value="Ngar_c17190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17190"/>
    <dbReference type="HOGENOM" id="CLU_2010013_0_0_2"/>
    <dbReference type="OMA" id="IRIYGKW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1717-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="15554" checksum="698774EABAE4E2F0" modified="2012-11-28" version="1">MPKQDPTPLPYGLLQYYQVHYILKVESGENGNFLARCEPITKGHFGNKQVVGVRWTGADEFAEVLQEDAKLIEMLKEVMLREGEIRVDPLDDHIRIYGKWIHEDSFAFNQAMLEIADRIAGHIKTRLHILNKPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK63</accession>
    <name>K0IK63_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ordered locus">Ngar_c17340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17340"/>
    <dbReference type="EnsemblBacteria" id="AFU58667">
        <property type="protein sequence ID" value="AFU58667"/>
        <property type="gene ID" value="Ngar_c17340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17340"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1708"/>
    <dbReference type="HOGENOM" id="CLU_083987_0_2_2"/>
    <dbReference type="OMA" id="ANAEYKG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="161" mass="18568" checksum="273645BA3D692211" modified="2012-11-28" version="1">MIDMPQFGYAFQNYDKTKHVRASIREKDISHKHSREIAVAIKGMSIEKAREFLENVIARKEAVPYRRYNMEVAHRSNIRDGFFAGRFPEKAAGEFLKLLDNLESNAEYKGMDLDRLRIVSAAVHKGTKLQRFQPRAMGRSSPKYDTLVHVELVAQEARGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK88</accession>
    <name>K0IK88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17840"/>
    <dbReference type="EnsemblBacteria" id="AFU58717">
        <property type="protein sequence ID" value="AFU58717"/>
        <property type="gene ID" value="Ngar_c17840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17840"/>
    <dbReference type="HOGENOM" id="CLU_1682755_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1782-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="16707" checksum="9F486E538F719F99" modified="2012-11-28" version="1">MNVVVLIFPPSASTSRRALARSIRGLDIRISNEGGCIICEGRDPTKLASRLANLAGADITTIARKVPSRFSSITNAIVQAGSETILPDEKFYVKVIQQAAKADYVDRDIEFASTGALVGKLAEINALPAKSEQEADRVILAIVGKKSAYICVKDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK97</accession>
    <name>K0IK97_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">metK</name>
        <name evidence="17" type="ordered locus">Ngar_c18090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18090"/>
    <dbReference type="EnsemblBacteria" id="AFU58742">
        <property type="protein sequence ID" value="AFU58742"/>
        <property type="gene ID" value="Ngar_c18090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18090"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1787"/>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_2"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="233"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFU58742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="380" mass="41623" checksum="EFA78DC1A91E2D29" modified="2012-11-28" version="1">MVRRWLFTSESVTEGHPDKVCDQISDAVLDDFLRQDPDSRVAIESMTTTGIVFVAGEVTSKGRVDVQKIVRDTIREIGYDKPDYGFDCDSCAVLAALHEQSPDISLGVTATSNKEQGAGDQGLMFGYATNETPELMPLPITMAHQISMKLAQVRKKKELSWVRPDGKSQVSVVYEDGVPKRIDTVVVSTQHSPDIGMSQLREEIINKVVKPVCGSWIDSRTKFLVNPTGRFVIGGPPGDTGLTGRKIIADTYGGMGRHGGGAFSGKDPSKVDRSACYMARYVAKNIVAAGLADKCEVQVAYAIGVAEPVSIMIDTFGTGKASEEEIEAKVHKVFDMRPAGIIKTLDLKRPIYHKTAAYGHFGRNDQNFTWEKTDKAFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE4</accession>
    <name>K0IKE4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59708">
        <property type="protein sequence ID" value="AFU59708"/>
        <property type="gene ID" value="Ngar_c27870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27870"/>
    <dbReference type="HOGENOM" id="CLU_665015_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2787-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="413" mass="49157" checksum="9C154EA1880BFF07" modified="2012-11-28" version="1">MSTLQFEQHIDLWAKHREKITSSILRILSQRPHTIPELAKKLDLSYTATFEWLTRMNQIEVVYEDKAAWIGLRDHRYNIDYESPDIDSIPAYCFYNIHLIHDWYRYAQTRGQKDDLRTFKNLCYGKVVPTFKINPVYWRHPETTKQFRDSYEKRFKAPFKPHIRDAVRTFLQLCLGVRLTKYDSAILGLKVVAPNEGKYRYLKLTKDEFDKAERWLESDECKQLCEQQGIRHSALLCHWAIAISSFGRPSSVLALETRAIENHGFLNRTALHFMLQESKQQKIFPKYVMEEKLVKWAESYWKFRLEDTRQGWRYLFITDLKELPDTRKKYSAIYKALFRHLDKKEPVWHEDSLYCIRHIGIQRWIMVHGFAAIPMLQVMGFPIDKTLFMHYAGLAPQDFLKAASSLNFQQLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG0</accession>
    <name>K0IKG0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c28180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59738">
        <property type="protein sequence ID" value="AFU59738"/>
        <property type="gene ID" value="Ngar_c28180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28180"/>
    <dbReference type="HOGENOM" id="CLU_3002959_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2818-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6324" checksum="75B8D97AFE52CC01" modified="2012-11-28" version="1">MGLFRKKADEQKVWKCPHCNMTFDEKERMKRHVRKAHGEKGGGDMPNMNPFGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH0</accession>
    <name>K0IKH0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative iron sulfur domain-containing protein, CDGSH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c28380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28380"/>
    <dbReference type="EnsemblBacteria" id="AFU59758">
        <property type="protein sequence ID" value="AFU59758"/>
        <property type="gene ID" value="Ngar_c28380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28380"/>
    <dbReference type="HOGENOM" id="CLU_145019_3_0_2"/>
    <dbReference type="OMA" id="EVHICGC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2838-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7412" checksum="37317015A24EA638" modified="2012-11-28" version="1">MARLVRKEDKGPMAVKVGSETKWICMCGLSANQPFCDGSHKKTLDEQEGKVYIYNKDGTRTEAKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH5</accession>
    <name>K0IKH5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">pdxS</name>
        <name evidence="6" type="ordered locus">Ngar_c28480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28480"/>
    <dbReference type="EnsemblBacteria" id="AFU59768">
        <property type="protein sequence ID" value="AFU59768"/>
        <property type="gene ID" value="Ngar_c28480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2818"/>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_2"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="31"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="323" mass="35258" checksum="59D6698D28AE9339" modified="2012-11-28" version="1">MTISLVATEPKPKGVKVEIVENARTVRGTTLLKRGFAHMCKHGVVMDVTNVEQAVIAEEAGAVAVMVLDKLPYDVRKAGGVARTASIKVIQEIMDAVTIPIMAKCRIGHIDEAKVLEATGVDMIDESEVLTPADEERHIWKWDFTTPFVNGGKNLGEALRRIEEGCAMIRTKGEPGTGNVAEAVTHIRMVNGEIRKLRSLYEDNDKQELMKAARELKVSYAIVEETARLGRLPVVNFAAGGITTPADAALLMNLGCDGVFVGSGIFKSDDPAQRARAVVLATTFHDDPKIVMEAQKMVDEKKSLLGMDTKNLELRMQERGQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKL2</accession>
    <name>K0IKL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59828">
        <property type="protein sequence ID" value="AFU59828"/>
        <property type="gene ID" value="Ngar_c29090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29090"/>
    <dbReference type="HOGENOM" id="CLU_942047_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2909-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="295" mass="33469" checksum="0AB35A221E608508" modified="2012-11-28" version="1">MALLEILSSGARKLILEELAKDDTRPVSAYALAKVSGYTQRTISEECKRLARADILKPVKIGEGQNGYVYNDNPIAQGLRSLILDNLQRMESNSVVEKIAKNLRMTDYYISLPLGLKVSYDVFYVPNYLLVIVDKNNTKAVDFLENIAKETKEGKVIVKKESLWGREYKFDANTGASIASIEQAMADGLEYYQTVKDTEVIRVLLARTSSIDIKKLNKLSDIRGASRAYRALSLKDRFLKDYSSKEFQKRAIRNDIDGFFSSDLKAQILPTLFPNETYRPEQIQMLNNALPNFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKN8</accession>
    <name>K0IKN8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59873">
        <property type="protein sequence ID" value="AFU59873"/>
        <property type="gene ID" value="Ngar_c29550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29550"/>
    <dbReference type="HOGENOM" id="CLU_2629857_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2955-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8600" checksum="70787F8695AF031D" modified="2012-11-28" version="1">MVYRNSIDAFQQLLLSPAVSQISAKSGHMQNGISYCVVQVSFANGDEYRIEAFDEEADELYRVAREQSSLLCLHANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKW7</accession>
    <name>K0IKW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative general stress protein GsiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gsiB</name>
        <name evidence="2" type="ordered locus">Ngar_c22570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59187">
        <property type="protein sequence ID" value="AFU59187"/>
        <property type="gene ID" value="Ngar_c22570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22570"/>
    <dbReference type="HOGENOM" id="CLU_1665554_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="16882" checksum="6F345308DBABE649" modified="2012-11-28" version="1">MGSEADAGRARRGLASANEETRQRVARKGGIAPHQKRGLAAANPETRMRVAKAGGEARAQDREGLSVAGRRGGEVVKERYGSDFYREIGEKGGGAVKERYGTEFYSEIGKRGGETVKQERGAEYYSTIGRKGGEARTVAEKPEEVQTTTDTTGVSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKX9</accession>
    <name>K0IKX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/carboxylesterase family protein</fullName>
            <ecNumber evidence="2">3.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31320"/>
    <dbReference type="EnsemblBacteria" id="AFU60048">
        <property type="protein sequence ID" value="AFU60048"/>
        <property type="gene ID" value="Ngar_c31320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3109"/>
    <dbReference type="HOGENOM" id="CLU_049413_6_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3132-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="24231" checksum="2BEB4382D93623BA" modified="2012-11-28" version="1">MAPPEIPRRLGFVHRYVPPAKGTAARKQTTTTLLLLHGTGGNEDDMLPLGQALDPDAALLSPRGKILEAGMTPRFFRRLAEGVFDIDDLKYRTHELADFVEAASCAYGFDEGNVLAVGYSNGANIAASTLLLRPKTLSGAILFRAMVPLVPDKLPDLSGKRIFMSSGLRDPIVPRQEAEKLSKLFEQSGATIVTLKWQKNAGHELTDDDIQSARQWLLQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL41</accession>
    <name>K0IL41_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60138">
        <property type="protein sequence ID" value="AFU60138"/>
        <property type="gene ID" value="Ngar_c32220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32220"/>
    <dbReference type="HOGENOM" id="CLU_2802404_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3222-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7876" checksum="7202E6FDCB2AC051" modified="2012-11-28" version="1">MMIIKNTDPYKMKKCVSCKRDIALGEKYFTYPLSLQQVCLQCAEKEIPKTIKALQKDLDKIRQEKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL44</accession>
    <name>K0IL44_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="4" type="ordered locus">Ngar_c23920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23920"/>
    <dbReference type="EnsemblBacteria" id="AFU59317">
        <property type="protein sequence ID" value="AFU59317"/>
        <property type="gene ID" value="Ngar_c23920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23920"/>
    <dbReference type="HOGENOM" id="CLU_076922_1_0_2"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="16875" checksum="A2FB76668AB40662" modified="2012-11-28" version="1">MQKQQKTAVVVDATNCIAGRMCSHVSKLLLQGNRVVIVNAEKAMLSGNHYKTIELYKEHLEINSVTNPIHGPFHPRRPDTILSKMVRGMVPKRKSSGMTAFKRLRVYIGVPEEMKGAKMESFSDSKITKPESYYISIGEIAKQIGWKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL71</accession>
    <name>K0IL71_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60188">
        <property type="protein sequence ID" value="AFU60188"/>
        <property type="gene ID" value="Ngar_c32730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32730"/>
    <dbReference type="HOGENOM" id="CLU_214147_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3273-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="6292" checksum="DEA5A3192CB5CBD6" modified="2012-11-28" version="1">MPTTVREMFGFTIYLMHLADYLQGRKDRTCPICKRRFDTFKEMDIHRQKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF1</accession>
    <name>K0ILF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57039">
        <property type="protein sequence ID" value="AFU57039"/>
        <property type="gene ID" value="Ngar_c00890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00890"/>
    <dbReference type="HOGENOM" id="CLU_1425127_0_0_2"/>
    <dbReference type="OMA" id="ERASDIM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-89-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="190" mass="22441" checksum="F5A29412639002CC" modified="2012-11-28" version="1">MRRKYVKLSLGADVLKQVICTIKIRRAPARHDDNVDFKPLVERASDIMPLSLVVADKGYDSEENHVFVRERYHAYSIIPPRYQDVPVWRTHGRYRKQMKRGGYLRPLYNQRNKDETIMSVMKRLFGEHVRSRLVRTQNRELAFRCIAYNNMHRVTNLLVIVIDFYKADEILSAVVAKILPLLWVALVLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI2</accession>
    <name>K0ILI2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60438">
        <property type="protein sequence ID" value="AFU60438"/>
        <property type="gene ID" value="Ngar_c35250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35250"/>
    <dbReference type="HOGENOM" id="CLU_2534842_0_0_2"/>
    <dbReference type="OMA" id="NGISAEW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3526-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9740" checksum="A3D53D557893C34B" modified="2012-11-28" version="1">MDAYLEEELYDLLTYCIQSPQAPDFADKKGRVQEIGRELYADGGTDALENMFFSIEHRVKEEIGQDARPYRAWWNGISAEWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK2</accession>
    <name>K0ILK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60473">
        <property type="protein sequence ID" value="AFU60473"/>
        <property type="gene ID" value="Ngar_c35600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35600"/>
    <dbReference type="HOGENOM" id="CLU_1431692_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3561-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="22056" checksum="0A9F1FD6F35E85CB" modified="2012-11-28" version="1">MASFNYKGIEYSDLISREMSFSIARTIQNIPDRNCFAITEQNKQEFPAGVIDSISEADRNFEEQRDLPSSEIGPLVYSWSTVQGVDNHSTLEILKKYHFYSKIETTRQNFRQIQDNTYIFECFFEYNENQYWAQIYFDTYYPRYVRFVTVNFTSSEDGKPTILNPDTVVSSGDVNATVLFINKLGSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILS0</accession>
    <name>K0ILS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative polyketide cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27160"/>
    <dbReference type="EnsemblBacteria" id="AFU59637">
        <property type="protein sequence ID" value="AFU59637"/>
        <property type="gene ID" value="Ngar_c27160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27160"/>
    <dbReference type="HOGENOM" id="CLU_1823279_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2716-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16131" checksum="F67DC54D2123D8F6" modified="2012-11-28" version="1">MVRVQIFKTIDAPQDKIFSIITDFERLPSRLPDRYKSLQVLERTGNNIVTVKETIVYAGREIHQITRHEIDPSRRLRSEVIEGDTKGTVVEITFEPDDAGGTTTRVSVDLDLKLGKLGSVLGVFAKGRIKGGLERMMAQFCNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV6</accession>
    <name>K0ILV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59707">
        <property type="protein sequence ID" value="AFU59707"/>
        <property type="gene ID" value="Ngar_c27860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27860"/>
    <dbReference type="HOGENOM" id="CLU_1773259_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2786-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16990" checksum="92A0F4FF1D749661" modified="2012-11-28" version="1">MEGPSDNERINKALRYIERKRKAIQELRNLISSSKDKNKDNIPVEVKQKVDEIFGCLSAVELLVGGKMGRKIHQETERLVEQWMWLQKAVLVFHLGLDRLQLTEMWLTNLSTLRIGFDKKGRNWTVNWKVNPFTNQYEGSFSTGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV8</accession>
    <name>K0ILV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04420"/>
    <dbReference type="EnsemblBacteria" id="AFU57389">
        <property type="protein sequence ID" value="AFU57389"/>
        <property type="gene ID" value="Ngar_c04420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04420"/>
    <dbReference type="HOGENOM" id="CLU_1709189_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-441-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="153" mass="17721" checksum="241596FEA0121350" modified="2012-11-28" version="1">MANRLIPSLLKYAGAGKRNSAEIFVGLKGLRTAYEILLQDAARGDILRYFYPFDDYHEIASPIYARLHLFQKQKRLDERGIGTTAFQKSKHYQELKNVNMRFVSFPLPGTMDIFGDKMLMVSWENTTAILITSKEINDHFKQYFDSVWSMAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM03</accession>
    <name>K0IM03_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase, AAA-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c29290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbbQ/NirQ/NorQ/GpvN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29290"/>
    <dbReference type="EnsemblBacteria" id="AFU59847">
        <property type="protein sequence ID" value="AFU59847"/>
        <property type="gene ID" value="Ngar_c29290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2904"/>
    <dbReference type="HOGENOM" id="CLU_779916_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2929-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013615">
        <property type="entry name" value="CbbQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08406">
        <property type="entry name" value="CbbQ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="94"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="355" mass="39933" checksum="DB23197DADFF109D" modified="2012-11-28" version="1">MDYLGKDAHADGVGNNKVTTRLRTFNQQSKITLQISRLKSYESPLKKKYDVEKYDLTSNYVFPDSMSELIPKHTPEYIDHGQRYVERIMRALYYFKQCALIGPSGTGKTHIVYAVAEIAGLPLWEINCGLQTTSFDLFGRYIGLGKENWVDGQIVSWCRHGGILYLDEANMMKQDVATRLNPLLDTRGHIVLNEKDNEIIPRHPLSYVIISMNPFSVEFAGTKPLNAAFRRRMSVWINFDYLSTGSKVNESEIDLIQERGGVTREIAMQMVKAAAQLRANYKKGDLPYGPSVGDLINWAKLVADGLDIHTAAEETIVSTTSDDIATQESVRRIIKLAGGHQLLRPSIQSAETLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD2</accession>
    <name>K0IMD2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb10</name>
        <name evidence="7" type="ordered locus">Ngar_c32520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32520"/>
    <dbReference type="EnsemblBacteria" id="AFU60167">
        <property type="protein sequence ID" value="AFU60167"/>
        <property type="gene ID" value="Ngar_c32520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32520"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="ISHHYID"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="297" mass="32346" checksum="E1101C245EDAB0EA" modified="2012-11-28" version="1">MLIKSAGIICPNCGDGQKVTDVESGELICTKCGFVIRERVGNEEEDWSVLAREPGSKLRTSPTSLARSGMGLSTIIGRPDMSAGSGLNAAMRSTFDRLRAWDFRIKGQDERSLRRAFVELDRLRSALGLSDAIVEKTAYIYRRAQERGLVRGRTMRAVLGAAIYIVQREMGVSGTLQDIINATNTTEKDLARAYRILLRELDLKVPMLDPAKCVSRVASKANISERTKRKAMDMIYNVIKSGLAAGKDPMGLAASVLYIACTSSGEPKSQAAIADAAGVSEVTLRKNQRMIIEQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML6</accession>
    <name>K0IML6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57999">
        <property type="protein sequence ID" value="AFU57999"/>
        <property type="gene ID" value="Ngar_c10570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10570"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="OMA" id="TIMLIED"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1055-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14969" checksum="157096DC76DE347E" modified="2012-11-28" version="1">MGLRQQDKVQTIMLIEDEEDILLVYRDFLERRGYRIEVSAPTANEILRDYEAYQPDLVLLDYRLPGYMNGLQAAEKILQKDPMARILIVTAYEDAKKELAENKFFNGKKISILIKPVQLGQLARLIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ5</accession>
    <name>K0IMQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phoU3</name>
        <name evidence="2" type="ordered locus">Ngar_c35740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35740"/>
    <dbReference type="EnsemblBacteria" id="AFU60487">
        <property type="protein sequence ID" value="AFU60487"/>
        <property type="gene ID" value="Ngar_c35740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35740"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3582"/>
    <dbReference type="HOGENOM" id="CLU_1329514_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="62"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="23299" checksum="715C781ECB62482C" modified="2012-11-28" version="1">MTFGNEYQFNAPSHSRNVRRKPRHGKFASKLWLRKNNKRQAFGNLTRLVYLGIDHVRNIIIDIARLSEHSVVTAIDSYAKGISSKKTIFEWSEQLRVLQDEVGDLAIELIACYQPVATDLRFIRSCMEIAYGFSRFGRYAYDIVDVLETMGSISECDKSAVLEMAKTARGDDTHERGDTSIQGQKCCRKAVPDGQHCGCALQKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT5</accession>
    <name>K0IMT5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58184">
        <property type="protein sequence ID" value="AFU58184"/>
        <property type="gene ID" value="Ngar_c12440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12440"/>
    <dbReference type="HOGENOM" id="CLU_968445_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1242-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="287" mass="33300" checksum="1F88B5D813F016B1" modified="2012-11-28" version="1">MSTDLAEELKIQSVRDLEQAKSILKQGENLEHVAWFCEQSYEKLIKHVYAHFKIKIQNRSVSGVYDKIFRAGHYDSPDLVLNMLGELAREFWDMYNRGLSVLPKLSDSDRTILKRFIDNVPQDALRRNERHIESIRRKIDMVVNKDKEFESFLRNSTYEKLHESMMKYDYNQIIDQTVAKNTAGLEGLVGVDPNVLMKGINSQLYKDYYLFVAKLLGLAEWLLPNISGSRYPLRESGFGNLKLYRELNDQLILFFGYMVSILDGLQTGKDRFISSIISILKTGSDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX5</accession>
    <name>K0IMX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58384">
        <property type="protein sequence ID" value="AFU58384"/>
        <property type="gene ID" value="Ngar_c14480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14480"/>
    <dbReference type="HOGENOM" id="CLU_2103584_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1446-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="13357" checksum="78F1771985D29290" modified="2012-11-28" version="1">MKGISALKKDHVYGKIIKYTAEDTGLGVINNPDFIDATVSVMSHWLNDLIRQSWIRKLQECQKNNDMQGASEIKKLKEAWLLSFAILYERRDPTPYSFMNTTTSTTTYCDKRYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN22</accession>
    <name>K0IN22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c16860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16860"/>
    <dbReference type="EnsemblBacteria" id="AFU58619">
        <property type="protein sequence ID" value="AFU58619"/>
        <property type="gene ID" value="Ngar_c16860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16860"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1664"/>
    <dbReference type="HOGENOM" id="CLU_116133_0_0_2"/>
    <dbReference type="OMA" id="ESGRCKP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1684-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20401" checksum="773CAAD039471C49" modified="2012-11-28" version="1">MLPRLEYIKQARIRLGITQRKLAALTGVSTSMINQIESGRCKPSYDTARKIFEILGSLEGRTSMKAGDICSRRLISVQRDEKLHKAIDVMRDNSISQIPVFDSSRVVGILTEDGLAKVMVEKEEEDLKNMHVAQVMEPPPPIVDVSTPAKALIPLVRFAKCILVSEKGNVIGIVTITDTLKMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN26</accession>
    <name>K0IN26_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17060"/>
    <dbReference type="EnsemblBacteria" id="AFU58639">
        <property type="protein sequence ID" value="AFU58639"/>
        <property type="gene ID" value="Ngar_c17060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17060"/>
    <dbReference type="HOGENOM" id="CLU_2930313_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1704-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6828" checksum="EBBD659F17F29329" modified="2012-11-28" version="1">MAIEEMSAIFEGTLVKWGNSLGVVIPKPVQRGMALKPGEKIRFRLEKNKLCIEKIEKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ9</accession>
    <name>K0INJ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59504">
        <property type="protein sequence ID" value="AFU59504"/>
        <property type="gene ID" value="Ngar_c25820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25820"/>
    <dbReference type="HOGENOM" id="CLU_103230_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2582-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="234" mass="25036" checksum="C2A3B76E59701249" modified="2012-11-28" version="1">MKTIQSDRHMGKSIGFGAIGGFVAGLVMAPFFMLTAMMAGMPTNTIPIAIGLAFGAFQDNNAIMIGSGLHMLTSTLIGIIFGAVTAAASKLRITSFRKGVGEGLATGMIAFAVLFIPISMFVMSPVLVQMMMQMDLSLTQQQAMSVLQQGIPLMIGIGILEHLVYGAVLGAVTSALMLKVKRVRKEQEYTARLGTGTTKEEGTTNYECMACNRKFGSLEEINDHIKTVHHRIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX0</accession>
    <name>K0INX0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Archaeal A1A0-type ATP synthase, subunit K</fullName>
            <ecNumber evidence="8">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpK</name>
        <name evidence="8" type="ordered locus">Ngar_c31930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31930"/>
    <dbReference type="EnsemblBacteria" id="AFU60109">
        <property type="protein sequence ID" value="AFU60109"/>
        <property type="gene ID" value="Ngar_c31930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3178"/>
    <dbReference type="HOGENOM" id="CLU_148047_3_2_2"/>
    <dbReference type="OMA" id="ERVWYLI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="8681" checksum="AE7C6880B9A45767" modified="2012-11-28" version="1">MTTEAAFAQEGGEGAAATPDSFKFIAAGMAFGLAALGAGFGLGFVGAAGLAAISENPKMQSSVFIIVGMVESIAIYGIVMMFIILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX3</accession>
    <name>K0INX3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60124">
        <property type="protein sequence ID" value="AFU60124"/>
        <property type="gene ID" value="Ngar_c32080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32080"/>
    <dbReference type="HOGENOM" id="CLU_1536587_0_0_2"/>
    <dbReference type="OMA" id="MSFGEVD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3208-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="18002" checksum="C71C547677ECD7CF" modified="2012-11-28" version="1">MSFGVDTLGGLAEKLKQLVNDTQNLYESFIDANQLYKQGKMGDKEFFSKIGEYLVAMSALNFLAVRVILEMKTAMEKGTSIKSPTGTSSYPSAAPQAGFGIGGFVGTGGSVGPAAAAGGEYTLPSPQEPAFKPVDIELPKTKAGSSNTKNCIVCDALIPAQAKFCSKCGRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP11</accession>
    <name>K0IP11_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60314">
        <property type="protein sequence ID" value="AFU60314"/>
        <property type="gene ID" value="Ngar_c33990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33990"/>
    <dbReference type="HOGENOM" id="CLU_2230469_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3400-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12510" checksum="B35BB9706B29FFEC" modified="2012-11-28" version="1">MLAKIAEYIAKKETRDFVLMLRNEYNITSALDVIETWIRIAGYPYRHEVNFSKQAYTIQHEMGRKWSVYLKEQYESLFEDFGLKRVDFTVTDTTLSFMVDTEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6S2</accession>
    <name>K0I6S2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56956">
        <property type="protein sequence ID" value="AFU56956"/>
        <property type="gene ID" value="Ngar_c00060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00060"/>
    <dbReference type="HOGENOM" id="CLU_2911643_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-6-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="7096" checksum="01965B848278E7DE" modified="2012-11-28" version="1">MASKNQEEEERALLTMTNIKYLVEGLDALLMTDLDGEKRRKVIQLRNELLAHINSIFNDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7K0</accession>
    <name>K0I7K0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="6">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspS1</name>
        <name evidence="6" type="synonym">aspS</name>
        <name evidence="8" type="ordered locus">Ngar_c02730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02730"/>
    <dbReference type="EnsemblBacteria" id="AFU57221">
        <property type="protein sequence ID" value="AFU57221"/>
        <property type="gene ID" value="Ngar_c02730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02730"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.267"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OMA" id="TSLDFEM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="147"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="443" mass="50351" checksum="702465DCEE5DC25B" modified="2012-11-28" version="1">MLQEQDLGHWRRTHYSSEISPSIGDSEVVVMGWVASVRDHGNIQFIILKDMHGEVQITAKKGECSEPIFEMAKEVKEHSSIGVRGKVRPQEKAPNGAEVVPSEIRAFSIAKKAAPFMMQGKTSTVGIDTRLDLRAVDLRRNYLGAIFRIRQTVLNSVREFLARQKFIEVNTPKMIATATEGGAALFPIFYYDREAFLAQSPQLYKEQLTMAFESVFEVGPIFRAEPSRTNRHLSEAISIDVERAFVDYNDVMSLLERMIVNIIETIKERNADDLKFLESQLPAVELPFPKYTYSDLIDKLQEAGERIQWGDDISPQVMKSLQDDRLNSFYFIIDWPTSTKPFYVKPGTADGGRVCESFDLMYGALEMSSGSTRINRKDQLVERMSKQGLKPDAFDYHLRVFDYGVPPHAGFGLGLERLMMALTKIENIRDATLYPRDIDRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I832</accession>
    <name>K0I832_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57431">
        <property type="protein sequence ID" value="AFU57431"/>
        <property type="gene ID" value="Ngar_c04870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.465"/>
    <dbReference type="HOGENOM" id="CLU_968388_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-485-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="30405" checksum="B520C22153F3492C" modified="2012-11-28" version="1">MTDDQNNSNNLECRLSGRTLQVYLYLQKKKEASRIREVQRDLGLSSPSVAEYQVEKLVEMGLAGRDSYGRVFVTRKVKVKALESYVNFGRFTVPRLAFYASIFTAIAALYAVFNFNSLNVYDVAVPAGAAAIFWFEAWKLWKYSLFEKAKKPAERDYFWASLMPGLAALAVFIAGTFFLFYYVEPSGLVSTAPPPADPNALPFQSAPQSPLTVDDLPAPQRNTGGDLPWLGFSPLQITILLFAGALVAGFVVYLMVKYRCDRGVLVSEQEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8B1</accession>
    <name>K0I8B1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57511">
        <property type="protein sequence ID" value="AFU57511"/>
        <property type="gene ID" value="Ngar_c05680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05680"/>
    <dbReference type="HOGENOM" id="CLU_2581532_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-566-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9570" checksum="6D5DB5447F70993F" modified="2012-11-28" version="1">MKLADIYTMIHFMKEAAIGVCGYWDQMYLLPLRKQDNKQVHSQVLQDVLLRLDKAYQAFFKKLAKYPRFKRKEKCELPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8F1</accession>
    <name>K0I8F1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ureC</name>
        <name evidence="14" type="ordered locus">Ngar_c06130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="9">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06130"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="AFU57556">
        <property type="protein sequence ID" value="AFU57556"/>
        <property type="gene ID" value="Ngar_c06130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.589"/>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_2"/>
    <dbReference type="OMA" id="GFDSHIH"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0533">Nickel</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="13">
        <location>
            <begin position="135"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="575" mass="62126" checksum="83ED8BE3D419A2AD" modified="2012-11-28" version="1">MVLKLTRKQYTDLFGPTTGDKVRLGDTDLFIQIEKDLITPGDECVFGGGKTLRDGLAQTSGVTNKNGALDFLITNAVILDPVLGIVKADIGIKDGKIAGIGKAGNPLTMDKVNPNMVVSACTEATAGEHTICTPGHFDTHIHMIAPQQYIDGISNGICNMIGGGTGPADGTNATTCTPGIYNISRMLEAVEDTPVNWGFLGKGNDSHPSLATQLEQIEAGACGLKDHEDWGTTAAVLDASLKAADMTDTQVAIHTDSINECAYVEDTINAIDGRVVHTYHTEGAGGGHAPDIMKIAGETFALPSSTNPTRPYTKNTVDEHLDMLMFCHHLNPAVAEDVAFAESRIRAETIAAEDVLHDEGVISMYSSDSQAMGRIGEVVIRAWQTADKMKKMRGKLPQETGDNDNFRARRYIAKTTINCAITHGVSEHLGSLEVGKYADIVMYPMAFFPAKPKMVLKGGFIAWSIMGDPNASLPTPEPVYYRPMFGAMGKAVHKTSYTFMSKRAIELGVPQKLGLEKVVLPVKNCRNISKKDMMWNDATPKIEIDPETYEVKLDGKIATVDPAEELSLAQRYFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Q2</accession>
    <name>K0I8Q2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57656">
        <property type="protein sequence ID" value="AFU57656"/>
        <property type="gene ID" value="Ngar_c07130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07130"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="OMA" id="SYTEYQK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-711-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10816" checksum="FF84A0B55089CF24" modified="2012-11-28" version="1">MNYKQLCKQILQKDNAIRFAGVATVEENNAAEEYQEGLVPLLTREESELSIMQPVIRTSTRKTFESKLGKTIYSYTEYQKIKRASFVLYNQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8X2</accession>
    <name>K0I8X2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative copper resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c07580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07580"/>
    <dbReference type="EnsemblBacteria" id="AFU57701">
        <property type="protein sequence ID" value="AFU57701"/>
        <property type="gene ID" value="Ngar_c07580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07580"/>
    <dbReference type="HOGENOM" id="CLU_136219_0_0_2"/>
    <dbReference type="OMA" id="LAFTTWI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-756-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="17618" checksum="F44C842DE63745E1" modified="2012-11-28" version="1">MALAESLVTWVHLICSSIWVGGSIFIGVVLVPVLKSNTKTLEELVALMVKVGRRFNKITVPAFGILIATGIYNSRGFIGDPSALLNTTYGTLLLIKISLVIATVVTYIVHVRLLNADMERKIMSGQGGNIYVQSVRTKIIILGEIIVVLSIAILLLAAMLDGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I959</accession>
    <name>K0I959_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c09190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57861">
        <property type="protein sequence ID" value="AFU57861"/>
        <property type="gene ID" value="Ngar_c09190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09190"/>
    <dbReference type="HOGENOM" id="CLU_2392985_0_0_2"/>
    <dbReference type="OMA" id="IFVCHSC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-917-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10772" checksum="7991C04BCB186BCB" modified="2012-11-28" version="1">MITVDPRGTSQKCSRCGVEKAKEEERFDLSVRIFVCHSCGLVIDRDLNAAKNIEKRGLEQTLAETEPLLVRHQRQRISKFQSRKQEAREFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9D6</accession>
    <name>K0I9D6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10090"/>
    <dbReference type="EnsemblBacteria" id="AFU57951">
        <property type="protein sequence ID" value="AFU57951"/>
        <property type="gene ID" value="Ngar_c10090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10090"/>
    <dbReference type="HOGENOM" id="CLU_531717_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1007-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="512" mass="56156" checksum="1640B088067551CA" modified="2012-11-28" version="1">MKTRAIFAGAGAASFYGWLQYTSPDALLGLLDTNSIMADPLNPMIIIPPLAAAGVLLPKFIKMPGRIGLPKFKQNGVSNNQYVESGATLLEFGKNQDIKGPNTNSIPFQMVSASSTSSSSAATTATGSPGQSKDASPPSQQPAVAANQTGTTTPVQVDESKLSAIVESKTSKMVEEVETIKKEMGSIVQDVQSLKTDIKELTSTFESSLVELKAFQSEMVNPVNFMRKYFELLDIKNVSDPVNVMMPIEQLVNNIGGASDTKHGGNAATAATTTEPGVRTKGNNIKNQQQDGDVKIIESQNTGSDKTTSSKTRAQTDEAFSIEEIYNILRQHRAEGFEEDDDGAEEDNDDEQYSNRKYRRTQAHRSHFSSLARSKIKNRNLMSKRSMIGSENEEFLGSSLESSLTPGRIMSIVSIVDEILASMGPDGIELVLEQYRAIGLRPEEERLIYGVVKMLNESKLLTDDIIAMLYRFGQVLGINDQDAELQYMKIVANKRNKKKRIARGMMPREDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9G0</accession>
    <name>K0I9G0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57986">
        <property type="protein sequence ID" value="AFU57986"/>
        <property type="gene ID" value="Ngar_c10440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10440"/>
    <dbReference type="HOGENOM" id="CLU_2010157_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1042-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="1">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="14293" checksum="F8C8D345D3EB29F4" modified="2012-11-28" version="1">MPISKTNISICKPSRITVGIDVGITKFCHDSDNNSIDNPLFLNNDLRPLRRAGRVLSRRLKGSNNWKKAKIRLQILHEHIMNKHNNFLYKLSTEYSKRYDVIFLERLHALNNGEKLPSCKVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA79</accession>
    <name>K0IA79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58226">
        <property type="protein sequence ID" value="AFU58226"/>
        <property type="gene ID" value="Ngar_c12860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12860"/>
    <dbReference type="HOGENOM" id="CLU_199456_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1284-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5805" checksum="4B940C246F9DCEA6" modified="2012-11-28" version="1">MNCLKCFHPHQAHEFNKGGNSSLLRVGRCLIPGCECTQYVDKIEKIDEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAT6</accession>
    <name>K0IAT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58446">
        <property type="protein sequence ID" value="AFU58446"/>
        <property type="gene ID" value="Ngar_c15110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15110"/>
    <dbReference type="HOGENOM" id="CLU_145173_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1509-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="14185" checksum="8CAD672D74126AAB" modified="2012-11-28" version="1">MSDMTDGGRSKKGTEPENLPEMIDNVIRQLDFNRKIIIIMVISFVIIVPIIAYIGFLSQTTAGVGRYIVIIGGVGFVAWLAVGIRQWMVFSKWLRKFRLYKERQKELEDLLDFEKSDEGKSSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB67</accession>
    <name>K0IB67_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspC</name>
        <name evidence="3" type="ordered locus">Ngar_c16330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16330"/>
    <dbReference type="EnsemblBacteria" id="AFU58566">
        <property type="protein sequence ID" value="AFU58566"/>
        <property type="gene ID" value="Ngar_c16330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1605"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="PGFPIYR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="459" mass="51452" checksum="F14A65535CCFC700" modified="2012-11-28" version="1">MAKNDELESLRRQVRDITAQIIRDVHRRMDLAKQIGEIKSMLGIDVKDEKVEHDIRLMVLSLADQIGMGRDFALQLLNILLAESEHVQAQKRPQKGQQKQTHLGIFMKAKQLEASGKKIIHMEVGEPDYSPPEAVGDSLAESFKQRQYHYTDTRGIPKLRDALAKKEGVSEDQVVVTPGGRFAVFSAITSLLKAGQELMVIEPAWPAYKECADFIGARTKVLRTTIENKWTPDLKQLEEMVNPSTKMIALNYPNNPTGKILDGKTMERIVSIAKDNDLYILSDEVYADYAFKKFASIHEYDYDKCILVSSFSKRYAMTGFRVGYAVASKDVIAKMSRVQAVGITSVAEPMQYAALAALGEDPSENIRTMKKRLDFVSGKLKEMSLQFVEPDGAMYVYPELPKGDDIMLVEKLLEKGVAIAPGSGFGDHYRQFVRISACQPEKTLEMGLDIMASVIKEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBF7</accession>
    <name>K0IBF7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58621">
        <property type="protein sequence ID" value="AFU58621"/>
        <property type="gene ID" value="Ngar_c16880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16880"/>
    <dbReference type="HOGENOM" id="CLU_1521916_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1686-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="1">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="19627" checksum="F54640A25D98FFB0" modified="2012-11-28" version="1">MVDDDNMLGAKSSSIGSIDAATGRFMKERLGFNFDNVRIHTDEAAAKSAESIGAQAYTVGRDIFFGRNMYEPGTIRGKELLAYELVHVILQAQSTEIKPHRNFANSSTDSLRAEVSHSAPADEVHLRPVTFNRRTFEVRDVILNAAASRDVRTHGNLCAWPRSGSYYNYRKSGTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC69</accession>
    <name>K0IC69_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RDD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c20190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58951">
        <property type="protein sequence ID" value="AFU58951"/>
        <property type="gene ID" value="Ngar_c20190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20190"/>
    <dbReference type="HOGENOM" id="CLU_104051_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2017-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="232" mass="25880" checksum="7094DA1419E28276" modified="2012-11-28" version="1">MTSEFDRGTSPSDRRTELTLARWSTRFWAWLVDFIIVNVALGVLFAIVAMPIWLTEFMNPSMISNGQWWNNIGGPFSFAINSLVFFGYWTYMESKYNGQSIGKMLLHIKTTNLDGKPADTKSIAISSFGKAFILPLDVLLGWIFTNDKRQRLLSRAANTIVIKAREETGDTANVRYTKGRFGEMQRGHTILIAGTVLLVAGIAITAVWRTSLASSFLADNTIVQTTSIQPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICS9</accession>
    <name>K0ICS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57460">
        <property type="protein sequence ID" value="AFU57460"/>
        <property type="gene ID" value="Ngar_c05170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05170"/>
    <dbReference type="HOGENOM" id="CLU_2505059_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-515-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9847" checksum="C1DE786905A6FCCA" modified="2012-11-28" version="1">MSKFLISDPSIINTEQSRRAEKLLATTLSLPRTSAQAIEQFYMEARRRLENLRQEMIQKIKNELWAAGDRTAARIRQTIGQAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID03</accession>
    <name>K0ID03_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rnz</name>
        <name evidence="10" type="ordered locus">Ngar_c23300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23300"/>
    <dbReference type="EnsemblBacteria" id="AFU59256">
        <property type="protein sequence ID" value="AFU59256"/>
        <property type="gene ID" value="Ngar_c23300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23300"/>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_2"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="201"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="305" mass="33876" checksum="8623CC8D7D94025F" modified="2012-11-28" version="1">MANMQLVFLGTSSAAPTVERGLSSIALMRGGELLLFDAGEGMQRNFIKAGLGMNRKMKIFISHMHADHCVGLLGLLQTMALQGRERSIDIYGEPRVKEFLEENMRIINFGLTFDVIVHTIKNEGVVVKEDEYQVTCCEASHSIPSFAYCLEEFDRPGAFNVKEAKRLGIPEGELYSKLQHGQDIVYKGKKIRSSQIVGPPRKGRKVGISGDTRPTDKLAKFFHGCDVLVFESTYSQDKQQKAIENWHSTAAEAAAIAKKAKVGRLFLTHFSARYDETSVLVKEASAIHPNVEAAEDLKVVEIPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDI0</accession>
    <name>K0IDI0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07630"/>
    <dbReference type="EnsemblBacteria" id="AFU57705">
        <property type="protein sequence ID" value="AFU57705"/>
        <property type="gene ID" value="Ngar_c07630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07630"/>
    <dbReference type="HOGENOM" id="CLU_023348_5_1_2"/>
    <dbReference type="OMA" id="TEGGCCW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-761-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="459" mass="50680" checksum="C8BAF3328E21C3D0" modified="2012-11-28" version="1">MKGNNGDFRSFLSLLQSEGELVRVKQDVSAEFELAAVTAKLDGKQAVLFEKVRGSKIAVACNVVGTPRRFYLAIAGDSRKVDQAAAADIKKAIHARITEALGSLSPPSKVQGGVPFEKNSSRNLHDLPIVTHFEKDAGPFITSSVVFAKDQEKGNQNQSTHRLLRLDDRHMAIRMVEGRHLHKCFTYARDHGEDLKVAIAIGVHPAVNIAAAYQAAYGVDEMLIANSLLGGRLVLAKTGYSQLYVPSHAEIVLEGRILKDRTHEEWMVEMLRTYDFKRKQPVFELERIRFCDNAIYHDILPGYAEHRLLMGLPVEAKMFDYVKNVVPTTQAVHLTDGGSNWLAAVIQIKKRLEGEPKNALMAAFSAHPSLKMATVVDDDIDPTDPVAVEYAIATRCQADRDLLIMPNTKGSSLDPSSDQANLLTTKVGIDATASLLKSKERFEIAKIPGEEKIKLADYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE19</accession>
    <name>K0IE19_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58010">
        <property type="protein sequence ID" value="AFU58010"/>
        <property type="gene ID" value="Ngar_c10680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10680"/>
    <dbReference type="HOGENOM" id="CLU_1574998_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1066-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="18260" checksum="95263A39CC317BCF" modified="2012-11-28" version="1">MISGEKLLIYLGVVLMLHGTYIILYDATAQSLNPLTTMGCFFSATGLIIAYVGLKGRDKVAEKLGFAMPELVEKHPLAYHAALAESNVQNQKNSSGNKAIGFILISVGTFMVTLTGLFPLSLNLLSSCCGWPDPSAIFSFLLLLLVSPLSTFGIICLSFGITFRRIAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE51</accession>
    <name>K0IE51_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59636">
        <property type="protein sequence ID" value="AFU59636"/>
        <property type="gene ID" value="Ngar_c27150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27150"/>
    <dbReference type="HOGENOM" id="CLU_2597866_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2715-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9287" checksum="33107A9EE301FC17" modified="2012-11-28" version="1">MEFLRKPAKTAEDMAKQLAPAEEHKENEDTFIQNTRSISLLQRSEPQRVLKELLPFSTSFMKLVIIFYSRSSWPLAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE83</accession>
    <name>K0IE83_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TldD/pmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c11490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11490"/>
    <dbReference type="EnsemblBacteria" id="AFU58090">
        <property type="protein sequence ID" value="AFU58090"/>
        <property type="gene ID" value="Ngar_c11490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1089"/>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_2"/>
    <dbReference type="OMA" id="LYRKSTF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1147-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="3">
        <location>
            <begin position="126"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="239"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="454" mass="49045" checksum="96A4EFC35778B877" modified="2012-11-28" version="1">MHCCNWRVAVILEDLLRYAIKEAEALGASDAEACAAASSESEVFIENNDIKQAKSQKPSSVGIRVFVRGSAGFCSVNSLSKSKIKDAVSMAVKIARVSPKDRYNVLPSRSKKPRMLQGIYDKNAQSFEASDAARMAAEMLAAAKLYDKRVSVDSGNFTADVSTQWLANSNGIELSEKTSIFSWSIMGMAIDGGDISSFDFQLGGSHFVRDIDVHATATEFAETVVNSLGPRRIESFKGEMLLTPAAINEMMEEVISHSINSDAVQKKSSHFAGKIGKKVASDLLTVEDDATNVEALGASSFDREGVPHRRNVVIEKGVLYKFLYNTYTAKKDGVRSTGNAGGSISSPPSVSTTNFVVRPGRSSLDTLVSEMKNGMIISRFSGNVNPVNGDFSGVVKGGRLVKNGTIQHAVKEVMVAGNVFEALRRLNGVSKERKVLYDSILPYMRFDGISFTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEU4</accession>
    <name>K0IEU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58285">
        <property type="protein sequence ID" value="AFU58285"/>
        <property type="gene ID" value="Ngar_c13470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13470"/>
    <dbReference type="HOGENOM" id="CLU_1529278_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1345-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19468" checksum="52F7E471F97F3496" modified="2012-11-28" version="1">MSEYDRILSELKEKVKVLASEYVPKLYRALLDEWYTPKAAKEKIMRDCAGLWTEQTIWANLPEESKDSKKREAGKKGAETRAKMTLAELPPPPPLEGSEEQEEERPYIPPAGIPVEATAAASGKEGYSTQTTYEPPKRPLSLFFVDIQRVAVCVTKGEATAAFQGLTDSFCLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEV1</accession>
    <name>K0IEV1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59886">
        <property type="protein sequence ID" value="AFU59886"/>
        <property type="gene ID" value="Ngar_c29680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29680"/>
    <dbReference type="HOGENOM" id="CLU_923222_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2968-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="301" mass="34227" checksum="19DC55663134269D" modified="2012-11-28" version="1">MELDQQPADKVSKLFRAISKKESLNLFLLAKDGIEAESSAPQKVGLSRKMYYTRLRQLVDAGLVSRYGNRYSHTVLGRIIYQEYVLSLFERIKDTKQLEMIEILKHAGRFSDYDIDNFVAKIMNAASSSVSRNGTISPPKIEIFWSYEASASKIARCVDLARNTIVFATRFYNETLINTILLKAKSRVDVRILADVGMVTHYLEMEKKGLQMLDKNAAERMNVVKDPWYPSSVNRRVTSVPFSMMLIDGKEAGVELVDSSSPQKFTGALYTNDEGICKQLMDFYDKLWLQASDNVPEKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEY1</accession>
    <name>K0IEY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lysine biosynthesis protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29980"/>
    <dbReference type="EnsemblBacteria" id="AFU59916">
        <property type="protein sequence ID" value="AFU59916"/>
        <property type="gene ID" value="Ngar_c29980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29980"/>
    <dbReference type="HOGENOM" id="CLU_195720_1_0_2"/>
    <dbReference type="OMA" id="EIVEHEC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2998-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13946">
        <property type="entry name" value="LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6204" checksum="DD4F3463BF054CF0" modified="2012-11-28" version="1">MKSKVECQECGADISVPEDAVVGEIVTCPDCGGDYEIASKSGDKVELKPAETVGEDWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF34</accession>
    <name>K0IF34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59971">
        <property type="protein sequence ID" value="AFU59971"/>
        <property type="gene ID" value="Ngar_c30550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30550"/>
    <dbReference type="HOGENOM" id="CLU_1472033_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3055-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="21424" checksum="B00D59B7DA9DA730" modified="2012-11-28" version="1">MPLYECNEHQFVENIRRLLESKEKFLVNRKITLHDDARYGPATMPDSEFKRYETICTRKSANSTVYAKVPFVDSFHGGRMYDEGENLHAASALMFPRMSVPYYRVEYSVNVWGGTYFFAFDALFNPEIVIEKRTGRKFGKSGALVHVLRYNPPEERVLAINLPKEVMVFDVKHMVRVIDHSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF42</accession>
    <name>K0IF42_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pelA</name>
        <name evidence="11" type="ordered locus">Ngar_c14640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14640"/>
    <dbReference type="EnsemblBacteria" id="AFU58400">
        <property type="protein sequence ID" value="AFU58400"/>
        <property type="gene ID" value="Ngar_c14640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14640"/>
    <dbReference type="HOGENOM" id="CLU_023334_0_0_2"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="355" mass="38947" checksum="3BF5E0CFAE7BC1A3" modified="2012-11-28" version="1">MIVKPSGASTNAFFVIPEDADDLFTLRRIIEKDDHVIADTTRVIKQVKEYGRPDKGERVKVRVSIRVEQSKLDAAVDRLRITGVIAETDNEMVTKGTHHSLSVQAGDMITIDKGRKWQEVELRMLNRSGSNASFILVAIDTQEAAVAKVSGTHVKVIPNIYSGQSGKRYQTKNNPNIEIYFTDIAKTVSSIIGENDKVIIFGPGETRRRFFNTLVARQEIPRDRVQVVDGVDVAGEDGIFVFLRSPAMKEAMSASKLASVSSMLDRVMLMVNRGEAKFAMGMQEVSQAAAMKAVEAVVFSDSIFKTAADEEQVVKLLNSIEGYGAKAFAVDSSTDIGLRVSSLGGIVALLRYAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF45</accession>
    <name>K0IF45_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58405">
        <property type="protein sequence ID" value="AFU58405"/>
        <property type="gene ID" value="Ngar_c14690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14690"/>
    <dbReference type="HOGENOM" id="CLU_1567059_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1467-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="188" mass="21024" checksum="171BAD20F9B7F2C1" modified="2012-11-28" version="1">MSTTKSLSLAVFLFTALTLTHAAFVDYRSGATETHPQQFKAVQDNKMANQMLYLHTRKLAGAELSFDFFGAGDRRDIIWRGLTKSKWTENGLCCGVFELLVKMKGGRTRTILLRSLLGPKNKLQLSHELGIDWKAVDGHISKLLQYGLAAEVMAVGTCRVYAITQKGRRALELADEWQEPDSNNIECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFI1</accession>
    <name>K0IFI1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rhodanese sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06450"/>
    <dbReference type="EnsemblBacteria" id="AFU57588">
        <property type="protein sequence ID" value="AFU57588"/>
        <property type="gene ID" value="Ngar_c06450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.623"/>
    <dbReference type="HOGENOM" id="CLU_031618_1_6_2"/>
    <dbReference type="OMA" id="RSFKEWK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-643-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="41"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="171"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="287" mass="32079" checksum="62B25D971742F2AE" modified="2012-11-28" version="1">MRSLTPGAAKKKKTAKASTAGSAVPQLSIVCDADTLRSLVRKRTVRVVDVRKEDDYKQEHIPTAVSLPLARVLENDTPEKIVSIMEELGISDKMPVVVYDDTFGALAARVAWTFQYVGHSNTALLEMTFKQWKELGLETEKQVRAFPRAKHSLNINKDIYADASYVEAAKSQPGKLLVDSRERLNFLTEHIPGAKNIPYTMVGSNGNILRKADELKRFIENRGITDNAEIITYCGSVGTLSGLTYYALKLAGFQNVKLYPKSFKEWKALGKPKEEFKDATYWDLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFK1</accession>
    <name>K0IFK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57608">
        <property type="protein sequence ID" value="AFU57608"/>
        <property type="gene ID" value="Ngar_c06650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06650"/>
    <dbReference type="HOGENOM" id="CLU_1363692_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-663-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="200" mass="23058" checksum="6A37FA275EAFB925" modified="2012-11-28" version="1">MNSLAGFLGQLSGKDRFKYVYEVQPLNFVMLPNAKQQELIERFRQFLNSLNSGILLVAKKSSKEIPIDDDSYQMQFYRYFVESDENIDDRLSSFGLLYNRISEIPSYTIIRKMSDRMILPEGKMVKTFALYKLSSTLVEGFVSETYGIADEVSIVIVPIAQEQATAKMNKYTKFLSGMILADQQKRRTSPYELVQKYTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFR5</accession>
    <name>K0IFR5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60206">
        <property type="protein sequence ID" value="AFU60206"/>
        <property type="gene ID" value="Ngar_c32910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32910"/>
    <dbReference type="HOGENOM" id="CLU_094092_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3291-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="265" mass="30103" checksum="7CFFDE7C65FFB43A" modified="2012-11-28" version="1">MSDLLKTHNISIIEMTNEHSILGIYKKVFDYLAAGFAIIYGVEMDGNNVKRKMAKLNETVLNKSISNGSLIIVDRPLIYAGRYHNPVDWSKNSLAKSILEAKHVSLNIRGIIIFVNPQIELETGNYKEEPLDFENFVGKRFNIPIEVVYCYDLKVVLSLKPSILLKILKIHHLSTIDTNSIHHTMPNKVMMEVATIFEQGLVDIFGKDASELIFKTLSILYGIDKHQIPLKLDIVEQKLENAIGRFNASRVFSAINLRLINECLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG68</accession>
    <name>K0IG68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60396">
        <property type="protein sequence ID" value="AFU60396"/>
        <property type="gene ID" value="Ngar_c34820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34820"/>
    <dbReference type="HOGENOM" id="CLU_2748330_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3483-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8022" checksum="1B682BA2D00A29A6" modified="2012-11-28" version="1">MLEKILQKMTKGYNGENKDITFQHHESSAYICQNCGHHESYHVDEEGICSCRQCCQMGGEPIVCEKFVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGF9</accession>
    <name>K0IGF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57918">
        <property type="protein sequence ID" value="AFU57918"/>
        <property type="gene ID" value="Ngar_c09760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09760"/>
    <dbReference type="HOGENOM" id="CLU_3323103_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-974-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="38" mass="4082" checksum="F8498EEBD12BF43C" modified="2012-11-28" version="1">MVKSAMVTFSITKNGKQPPFVVVRAEIATINECTVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGJ3</accession>
    <name>K0IGJ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flagellar protein FlaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flaF</name>
        <name evidence="2" type="ordered locus">Ngar_c10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57953">
        <property type="protein sequence ID" value="AFU57953"/>
        <property type="gene ID" value="Ngar_c10110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10110"/>
    <dbReference type="HOGENOM" id="CLU_1590796_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="19362" checksum="A2AA4A98BC215295" modified="2012-11-28" version="1">MGFSAAISGGIMMTMIIVVLIMAIPAVINANITTSRAYSERAQLDSEYIKTSIQITDLQALPDTDIVNVTLSNDGSSKLWNYQKFNVLVTYDYIPDPLASPQRITENLDYAGITQIVSAAGSWSITGFIDDNIDPQILNPEESLTIRGRLNHDIAISAELVAVTISTDNGVIVSKAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM9</accession>
    <name>K0IGM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative digeranylgeranylglycerophospholipid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10460"/>
    <dbReference type="EnsemblBacteria" id="AFU57988">
        <property type="protein sequence ID" value="AFU57988"/>
        <property type="gene ID" value="Ngar_c10460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10460"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.994"/>
    <dbReference type="HOGENOM" id="CLU_024648_0_0_2"/>
    <dbReference type="OMA" id="THFGSAY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1044-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="482" mass="53816" checksum="3C438572B273A1CE" modified="2012-11-28" version="1">MKRDYDIIVAGGGLAGLIVATSAAYYSHQSLKILVIDRNAIPQQGKKTVSGWVCGDAVGKNTVDYMTERIKISWGYPEIEHPVKGVIAYSPDHETGISFDGEGYILNRRLLPQRQLKDATKAGVEIKERVALRSLIVEGNTVIGVEGDDLDNKTVFKKTAKLVIDCTGVTSVLRTNLPIKSFIQRRINRDDLEATGRYIYNFDLAYDDKTFFDPDYCIIHLDQKLAPGGYGWVFPKGKSKVNIGLGVQQKAFDMRNKAMGVHPDLKTLIDEYVEANPVIKNPRLADGASDDGNAWGTWQVSVRRQNDCLVANGYMLVGDSAWMPKPLDAGGIGPAIIAATIAGKDAVEALQAGDTSEKGLWKYNKHFINDYGYKTAGLEVFRRMLQGLTNEQINYGMKHFLSKMDIDKITKGEHPEFSTVDKLGMMIRGAMNKKLAEDLRYCANMNKVLVDHYYNYPEAPEGFPEWHKTLTKHLEEAFAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS5</accession>
    <name>K0IGS5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantoate kinase</fullName>
            <shortName evidence="5">PoK</shortName>
            <ecNumber evidence="5">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c11060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11060"/>
    <dbReference type="EnsemblBacteria" id="AFU58048">
        <property type="protein sequence ID" value="AFU58048"/>
        <property type="gene ID" value="Ngar_c11060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1048"/>
    <dbReference type="HOGENOM" id="CLU_081191_0_0_2"/>
    <dbReference type="OMA" id="MLGETVF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1104-MON"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="296" mass="31382" checksum="DF45FFEBE0997736" modified="2012-11-28" version="1">MAKAFSPGHITGFFEIPYGSYSHFLHKGSKGAGFSIDRGISTTAYVYESATTDYQISINGVRSSNVDVSKWVVEEYLKLADRPYFVNVEHDIGIPVGFGLGSSGAAALSLSYALNEALDASLSRTQAAQIAHHAEIACKTGLGTVIAEFAGGFEMRTGAGAPGVGSVVKIDLENYYKAVVLCLAPISTKSFLTNMMDEINGLGGVMLSKLSKSRSVDEFLRMSHEFAETLGLTEGKCKEPIAALKALGIESSVALFGQTVFTLVPQTRSKQARDALKGFGGTLLVCNVDSNGARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGT4</accession>
    <name>K0IGT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c21190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21190"/>
    <dbReference type="EnsemblBacteria" id="AFU59050">
        <property type="protein sequence ID" value="AFU59050"/>
        <property type="gene ID" value="Ngar_c21190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2101"/>
    <dbReference type="HOGENOM" id="CLU_023387_0_0_2"/>
    <dbReference type="OMA" id="FADMRMA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2117-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="262"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="489"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="610" mass="67278" checksum="AA7B4E24A16D293B" modified="2012-11-28" version="1">MSNKKFVLDTSIIIDGEITKMLEAGDLEEGSEIIIPLAVLDELQSQASTNKEHGFVGLEEIKKMRELALAKRIGLKFVGQRPDLDDIRLAKHGRIDAIIKDVAMHESATLITADYVQALVAEAQGIKAMHIRAPTKTTDLEFEKYFDDTTMSVHLKEGTFPMAKRGKPGEFQLVKIGEERSTYAQLSNIIKEVSEASRVTGTGSVEISRSGATVIQFGNFRIAITRPPFSDGLEVTIVRPIVRLILADYNASKKLMERLSGKAEGIIIAGPPGSGKSTLASSLAQFYSERGKIVKTFESPRDLQVPEEVTQYSPLEGSFEKAVDILLLVRPDYTIFDEVRRRQDFEVFADMRLAGVGMVGVVHASSPLDAIQRFMGRVELGMIPHILDTIIFVRDGGIKKVYELSLTVKVPTGMTEEDLARPLVEVRDFETGAIEYEIYTFGEENVVVPVSKIAEAGGQPDSGVRKLAQSKIMDIVRRFDPHAEVNVISDNKVQVRVSKEAAPRIIGKGGATVSELEEMLGVKIDIEAKIPTLGKEIEFDISETGSSVNILLDDDVIGRTVDVYVEDEYILSSQVGKKARVKIDKRSESGRKIVNAIISGQEVRVFLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX0</accession>
    <name>K0IGX0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase</fullName>
            <ecNumber evidence="2">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysM2</name>
        <name evidence="2" type="ordered locus">Ngar_c21750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.47" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21750"/>
    <dbReference type="EnsemblBacteria" id="AFU59105">
        <property type="protein sequence ID" value="AFU59105"/>
        <property type="gene ID" value="Ngar_c21750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21750"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2155"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OMA" id="HIAKDMT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="333" mass="36944" checksum="78A278C9CC6F29CD" modified="2012-11-28" version="1">MTAVARPDIVERIGQTPLVELKSFSTKNVKFFAKLEWHNPFGSVKDRAAYWMIKDAEKRGVLKKDKSIIIEPTSGNTGIALTGIASALGYKVEIVIPEKVSEETKNILRHLGATLHETSDDLCPRVGAGTDQSIALAKAISKPRPDIYYMPNQYENDANFLAHYESTGPEIWKQTNGTVTHFLTGCGTGGTITGAATYLKEKNKNVHIIAVQAQKNHLLQGLRNFEESSMPELFKRREKVVDEWMTATNKDSFDAVRQLVEKESMLVGPSSGSVMTSMLKAAQNLKSGVIVGIFADDGRKFKSLYTQENVLSEQEYDRALKNAKHMSKLAYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGY0</accession>
    <name>K0IGY0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS1</name>
        <name evidence="8" type="ordered locus">Ngar_c21900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFU59120">
        <property type="protein sequence ID" value="AFU59120"/>
        <property type="gene ID" value="Ngar_c21900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2169"/>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="277"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="439"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="587" mass="64290" checksum="64E4BAC8019334CF" modified="2012-11-28" version="1">MCSIIGYKGKNAAAPILVDSLKRMEYRGYDSVGVATFDSGNILVRKGTGKVIEVNRNLNIDQMSGKIGIGHTRWATHGGVTDKNAHPHSACKNNIAVVHNGIIENYKELKQELIEVGHTFASETDSEVIAHLLEIHFSSGNNIKQAMIDTCKRLKGNYAFVAVFQDGTICGARYEEPLVIGVANDGYFVSSDVLGFLQYTDKAIFLENGDICIVDNSKLEIFDFEGRPIAHPITQVAWELGDIDKGKYAHYTLKEINDQRLTVVHAGRQDEATMEKFCNILASAKDIYITGSGTSYHSALIFKHMLARFGKIRAETVMSSESQYALASMDSNSVLVAISQSGETADVLDSVRLAKNQGANVLSIVNVTTSSLARASDAYLSTNCGPEIGVAATKSFTGQLALIYNVTDRLCKNCLETEKAEFAVAVENIIANQASIIKVAEQMKDASDIYLLGRSLHYPIALEGALKLKELAYVHAEGIAAGELKHGPLALMEKNTFVIMINPRDATFNDTISNAHEIKARGATVIGISDRKDDVYDYWIEIPHLKEEAYYPIVEVIPLQILAYQLALAKNADPDYPRNLAKSVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH59</accession>
    <name>K0IH59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22880"/>
    <dbReference type="EnsemblBacteria" id="AFU59215">
        <property type="protein sequence ID" value="AFU59215"/>
        <property type="gene ID" value="Ngar_c22880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22880"/>
    <dbReference type="HOGENOM" id="CLU_097039_1_2_2"/>
    <dbReference type="OMA" id="LWMLNMQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2286-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="18276" checksum="E75F7B8C4D2F1935" modified="2012-11-28" version="1">MARKSTVLIPVIIAAVAVGALGIAFVPPEIRDRDTAFPKGTVRIDDNVITVEIAETAAEQQRWMTFRQDRLPLDTAMLIKHDKPDLYEVWMLNIEYNLDLIWFDENGNAVYLKKDVPPCTNVVETVSCTYKTTKRALYVMAATSGFVDEHNIDIGSKMTIISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH78</accession>
    <name>K0IH78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative electron-transfer flavoprotein /FAD-dependent / fixCX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fixC</name>
        <name evidence="2" type="ordered locus">Ngar_c12680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12680"/>
    <dbReference type="EnsemblBacteria" id="AFU58208">
        <property type="protein sequence ID" value="AFU58208"/>
        <property type="gene ID" value="Ngar_c12680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12680"/>
    <dbReference type="HOGENOM" id="CLU_438458_0_0_2"/>
    <dbReference type="OMA" id="KGMNHAV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="623" mass="69425" checksum="EB01EB285772FCC3" modified="2012-11-28" version="1">MESYDVAIIGGGSAGLAALKQLSNLGKQAILLEAGKQVGTKNISGGILYSKKPKTGRVYNVEDVYGPEFLKDAPVERKITQYMLHSTSRNKVFTMNLTAAHEYQANFGYSVLLNRLNAWFARHAGESAERQGGGIVSGVHVRSLSWQGDKTVVETDELEPFEAKAVIAADGVNSEVAEITGSRPKFTPEQLYQGVKVVVKLPEEIIEQRFGIGPDEGAAHLFAGDVTLNHIGGGFLYTNRDTLSVGAVYHYDSLMDRPAEPYTLVNALLKNPMVAEFVKDEVAIKEEIDKNLPKEEQLRVRFAVSKLIKTWNELRDVWYSPAARKKLVEAGKYKTEEEIKARLDSVQNELANKYHTKFVTDYVELEYSAKLVPDGKRCAMKKPYFKNVLFVGDAAGRGVFIGPRIEGLNVGIDDAVRAANAVARAIDRNNFGPQYMGEYYSQLIEESPYTRDMKEIDKDYVKIFLDAARDVPKDIIGQRYGMVFRLMSSGTLRGLAVGFANILGYDKLLPLVESEDTYVQVPVELAEKMGRPIQATYEPTLPTVAQRVARLKYDDDRISHIKVLDSKSQFMKKMVTLCPTSCYSMEGGDVTLQHEACIECGTCAKETEWRHPRGEKGVIYQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHI2</accession>
    <name>K0IHI2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59390">
        <property type="protein sequence ID" value="AFU59390"/>
        <property type="gene ID" value="Ngar_c24660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24660"/>
    <dbReference type="HOGENOM" id="CLU_062440_0_1_2"/>
    <dbReference type="OMA" id="MDLANTE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2464-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="263" mass="29660" checksum="E22808C9B0AA2FEF" modified="2012-11-28" version="1">MGDHDREIKRLETQAKLFEPLTRQTLLAAGLKKGMSCADIGCGSGSVSRLMAEMVGVAGRVLGVDMDDRYLQYCRTVSPQHNMEFVHDNICESRLDGKERFDIVYSRFVFHHLNDTKKAVRSMIQLAKRGGAIIIQELDHAPGSWLSYPENKAFNSLREVYVALIKKTGADPLAGRKLYKLLMDESLDTTIECYSPCILMGCEPYSSLGWQLADSLKPRILKHGLQSEREFANMYKGLKELAKKKGSFVTYARLFSAVGRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHL4</accession>
    <name>K0IHL4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03190</name>
        <name evidence="2" type="ordered locus">Ngar_c03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57267">
        <property type="protein sequence ID" value="AFU57267"/>
        <property type="gene ID" value="Ngar_c03190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57297">
        <property type="protein sequence ID" value="AFU57297"/>
        <property type="gene ID" value="Ngar_c03490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03190"/>
    <dbReference type="KEGG" id="nga:Ngar_c03490"/>
    <dbReference type="HOGENOM" id="CLU_2629844_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-319-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8631" checksum="1E93DB43796DA2CB" modified="2012-11-28" version="1">MDGHFELKHPASIQDSQQMTFTDSSLAMQPKAKQKTCYVRKGTKRFSKVPYGIYAKRIKSSIPSIPTDRIAVFPGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHM6</accession>
    <name>K0IHM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03330</name>
        <name evidence="2" type="ordered locus">Ngar_c03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57281">
        <property type="protein sequence ID" value="AFU57281"/>
        <property type="gene ID" value="Ngar_c03330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57312">
        <property type="protein sequence ID" value="AFU57312"/>
        <property type="gene ID" value="Ngar_c03640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03330"/>
    <dbReference type="KEGG" id="nga:Ngar_c03640"/>
    <dbReference type="HOGENOM" id="CLU_1178158_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-333-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="26351" checksum="C9B10C6E4A8A82E7" modified="2012-11-28" version="1">MAPKIISVELMLRSGRNVVNLLNGTVDNEEQKVLTTFKELGFRSGHDLNIDRIRSIYIFADADLHLSYQGAEVEFDMMSYYKIIRPLDIEEITIQIDNVFVPDQNRVIIVASDDPCFDYGVSSAVPHLFYSNSVTAIAASYTNLFFRHTIGKKNKFTIVNGGAANINLDIQHREVPESDNNGSWVSYAGFPKVLNAGDTYVFGDDAMLDTQHHFHRVRVQSTGANVTVKGEMLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU8</accession>
    <name>K0IHU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57457">
        <property type="protein sequence ID" value="AFU57457"/>
        <property type="gene ID" value="Ngar_c05140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05140"/>
    <dbReference type="HOGENOM" id="CLU_736968_0_0_2"/>
    <dbReference type="OMA" id="SKPWAVE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-512-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="378" mass="43830" checksum="7B418D141A51D9EE" modified="2012-11-28" version="1">MPLQGLTGKHTFESFLVKVHHRDTNEEIRILAYVSNLTPERLFDSMKRFPTFHVTELGEIVEVRIERSSDSESKPREEESSDSETVSAQTSTTSTYYCHFNRRRGLLLCFTTDTLEEAGRTMDRFVNHTNGIFPLWIHPITFDKIRREIQSKNPDSIISEFHAHRYKMDGEDVIRPNYEERYFKYMADDGRFTLDELSKAYGVLPTSILFNILNVCKFRITNMGRFAFAHGDLDFLFNIINEVLAKVLETKALIEKAKIEFIPVNMGRKEVKLPKVIPVDIVFSREIDFSEVERLVDNMSGEDFNFEIFDMLLMPGSIHLSGTIVDRNKNIGFNITGNSEKITLSPRKDTNFDSMMQFYKMITERLDLKAEIRASTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHW5</accession>
    <name>K0IHW5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16100"/>
    <dbReference type="EnsemblBacteria" id="AFU58543">
        <property type="protein sequence ID" value="AFU58543"/>
        <property type="gene ID" value="Ngar_c16100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16100"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1578"/>
    <dbReference type="HOGENOM" id="CLU_054485_0_0_2"/>
    <dbReference type="OMA" id="YRYMKSE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1608-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="45"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="381" mass="42568" checksum="00DDA67FC104C489" modified="2012-11-28" version="1">MSSSYETLHGHATPEGTKKYVQRAASQGRPQAHFKTFDGLHLSSIGMGTYLGQPTQEDDLAVENAVYQSVKSGAVNVIDTAINYRAMKSEKSIGKALLRLVKDGVISRDQVFISTKNGYITNDGDYPNVDVMEYIHRMYIQTKVITADDISSSYNVMNPNYLAKCIDKSLMNMHLSTIDLVYIHNAFESWNQDVSRQQFMEMLAKAFEVYEKYRSENKIRYYGMATWTCFRVPPGSHEYLSLEQAIRIAESVGGKSHGFRFIQLPYNLAYSEALLLRNQSVGSANNLTILEAAAKLHVGVFTSIPLFQGRLLGAQVPDYAGISEPVGKLVQIIRSSPSVIAPLIGQKKPEHIEENLKVANVPPLSDKEFKEVVRVLTSQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX2</accession>
    <name>K0IHX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58548">
        <property type="protein sequence ID" value="AFU58548"/>
        <property type="gene ID" value="Ngar_c16150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16150"/>
    <dbReference type="HOGENOM" id="CLU_2534792_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1613-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="8800" checksum="D15AFDFCC3985EC4" modified="2012-11-28" version="1">MPGANAEPMAIPSENGSNIVVAANARSWNPTIIDADGKVIYLPPNGNYTITGTEKYVNSGFLRPHSQAPPGLPPTETFSVTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0II30</accession>
    <name>K0II30_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase-like protein, decarboxylating</fullName>
            <ecNumber evidence="5">1.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gnd2</name>
        <name evidence="5" type="ordered locus">Ngar_c06890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06890"/>
    <dbReference type="EnsemblBacteria" id="AFU57632">
        <property type="protein sequence ID" value="AFU57632"/>
        <property type="gene ID" value="Ngar_c06890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06890"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.666"/>
    <dbReference type="HOGENOM" id="CLU_024540_0_1_2"/>
    <dbReference type="OMA" id="PEYYQYD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="193" mass="21368" checksum="3C00FF2691EA1270" modified="2012-11-28" version="1">MVSDYASFVGFLKHPRVIYLSLPAGSTVDSVLNELIPFLEKEDVLMDGGNLFYLDSIEGKKRISERGIHFLDRGTNSGLEDARYGACFMVGGKEEDIRIPEPILIALAVNKDGYIHTGQPGTSHFVKLVHNGIESGMLQSIGEGVELLHKSGFELDLAAIFKNWSNGSMIRSCLPSLWKEALESRSWPRLKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II43</accession>
    <name>K0II43_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58613">
        <property type="protein sequence ID" value="AFU58613"/>
        <property type="gene ID" value="Ngar_c16800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16800"/>
    <dbReference type="HOGENOM" id="CLU_009583_41_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1678-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="455" mass="51305" checksum="FA49C9276463F940" modified="2012-11-28" version="1">MKILMVSGEYPPMTGGVARYTRNLVRALSKRADIEQVWVATSTVVEKLANNNSNSSGDGVNDPGLDGHKVYGIIKKGDRRNSDRLLRLVEELKPDIVNIQYERGLYEIDTTVCHTINRILHGSTLDKFYRACPVPTVSTLHTVFPYEEYQGYIKERARRKEGRFGFLPTPFRIAIRKWVMERRYDLLLQVVRLSTEIISPAETIHNVVKRGTVIYHGAEPALLSSEASSHLPSSNSTTNIRTVSAQTTITSTTTAAMPRNNKEEFRKQFGLPTNRMLLLAFGYVGSYKGFDLLDRLELPEGWSIVVKQTRHERGVEKPLSLKKESTISLDLGYMDDVTMSKLLSACDAIIFPYRVVSLSGVMFDALAHGLPFVASDLEFFKEFAKMGLGITSERTPAALAKALFTLAGEYGKFKRNVEQFAPRLRWDRIAEEHTRFYSKCITCYGNGSAKKMYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB1</accession>
    <name>K0IIB1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57752">
        <property type="protein sequence ID" value="AFU57752"/>
        <property type="gene ID" value="Ngar_c08100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08100"/>
    <dbReference type="HOGENOM" id="CLU_3094226_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-808-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5521" checksum="9ABDE34EFF10CEE9" modified="2012-11-28" version="1">MLGTTVPPPIWGQKNGRYAAGAAANWLKRNAVPVFGTLANIKSPQAWNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB4</accession>
    <name>K0IIB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF126 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08150"/>
    <dbReference type="EnsemblBacteria" id="AFU57757">
        <property type="protein sequence ID" value="AFU57757"/>
        <property type="gene ID" value="Ngar_c08150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08150"/>
    <dbReference type="HOGENOM" id="CLU_141583_2_0_2"/>
    <dbReference type="OMA" id="CEPIVAT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-813-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="13878" checksum="3C789638675A330A" modified="2012-11-28" version="1">MIIISNCRKIVGGSGEGQALVTAQPINFLAMVDTKTGRITDPKHDLYGKSLKGTVLVFPYAVGSSVGAYAIYSLRECGTAPSAVVCSKADITTASGCAIANIPVVDLPENAPAIKQGSITRVEADIGRITVKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN6</accession>
    <name>K0IIN6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BasA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58928">
        <property type="protein sequence ID" value="AFU58928"/>
        <property type="gene ID" value="Ngar_c19960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19960"/>
    <dbReference type="HOGENOM" id="CLU_1529279_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1994-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19089" checksum="5632F69D407C28E8" modified="2012-11-28" version="1">MMGDSSDLQYRNTPPEGPRKRVRSRRGSSEVLGAVLVAVITMGAFSVYASYALNQTSNEAQSVVQSLRKGTLKQGQLLSVVYHWEKVQGTSTQVKISLYNYGYSDVNVKYVFIDGVPQNSFNLLALDGKQVSAVKVGSVTNLVIDVPYAVNPIVSGQSYEAVLVTDDNLVYSWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP2</accession>
    <name>K0IIP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59795">
        <property type="protein sequence ID" value="AFU59795"/>
        <property type="gene ID" value="Ngar_c28760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28760"/>
    <dbReference type="HOGENOM" id="CLU_1006917_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2876-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="31832" checksum="19162A4210828B59" modified="2012-11-28" version="1">MRRLRRQKEAAEADKTQSTESKLTSRSFKFQKRQTVYFMISIAGIMLFSLVILVVTGTFDDFDLGNAISQIFRQLINPEMTGNVLRYWTLAAAAIIASVISAAFLFEINITSSTFVHIQHEWYWKYFLRHLIIKDKHGWHFMIGYFVSILIFHPVIAEQVWEVQSRLQEINLYQAYIITIPVVSTILVVARVLSKLDLAIIDTNIGVLIVLIYVSEIIFLTVTLSFVPFEQLYGFVSYPNEAQNQFIIYDSEVFAASLCMLADWLIIRVGMNKDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP6</accession>
    <name>K0IIP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Voltage-gated potassium channel-subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28810"/>
    <dbReference type="EnsemblBacteria" id="AFU59800">
        <property type="protein sequence ID" value="AFU59800"/>
        <property type="gene ID" value="Ngar_c28810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2857"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="RAWNDRS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2881-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="37548" checksum="84DACC66B7411172" modified="2012-11-28" version="1">MKYRTLGKSGIKVSEIGFGAWTIGLDWWGKKIDDDEAIRMLKRAYDLGINFYETADMYGKGKSERLMAQAFKDMRNEVIYSTKWGYDMYGAEQIGHSELPQKHDPEFLQFALGKSLERLQTDYVDVYSLHNPKMAAIRNDALFAALDDLVAKGTIKSHGAALGPAIGWKDEGLEAIKNRNITCLQTVYNILEQDPGRDFMREADRHDVGIIVRVPDASGLLTGKVTADTKFDKNDHRSFRKQEFIVEAMQKIENMKPIAKEKGWSITELAIKFILSQKKISVVLPTMISIEEIEMFASISDGKYLSASEAASVEQMYEKNFYVQPIASSNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS5</accession>
    <name>K0IIS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58012">
        <property type="protein sequence ID" value="AFU58012"/>
        <property type="gene ID" value="Ngar_c10700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10700"/>
    <dbReference type="HOGENOM" id="CLU_2646044_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1068-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8276" checksum="96BB721E6E3DFA3B" modified="2012-11-28" version="1">MFSQSIIPPLAFPVDAVGVLLALSDVVVCAAIGLNVPKVASTAKAIAAGTNNHTDFFRMFIEHYDYAMFLIIMRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV5</accession>
    <name>K0IIV5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59018">
        <property type="protein sequence ID" value="AFU59018"/>
        <property type="gene ID" value="Ngar_c20870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20870"/>
    <dbReference type="HOGENOM" id="CLU_175266_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2085-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="10730" checksum="7596D170059B7A84" modified="2012-11-28" version="1">MNWIGQQMAWIMVSLAISLVLTYFLGWYGIIPAIGIFLFISYYMRKRAMARMGMGGGGGFGGMLGGGGGGGVNYVCIACGHRFKGGACPRCGSKMRRVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ31</accession>
    <name>K0IJ31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">30S ribosomal protein S4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rps4p</name>
        <name evidence="9" type="ordered locus">Ngar_c21880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21880"/>
    <dbReference type="EnsemblBacteria" id="AFU59118">
        <property type="protein sequence ID" value="AFU59118"/>
        <property type="gene ID" value="Ngar_c21880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2167"/>
    <dbReference type="HOGENOM" id="CLU_089738_1_1_2"/>
    <dbReference type="OMA" id="ARQFITH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17403" checksum="FEDE3812277E72C1" modified="2012-11-28" version="1">MIWTTDQLNAELYIMGSYGLRNKRELWKAQTEVARIRNQARALLALSAEARAEKEKRLLNFLNRLGLAKEGATLDDILNLKVEDLLERRLQTIVMKKSGTKSPYQARQMVSHGHVSIGSRKVNIPGYLVRTEEEPQILLHIELPSAAAAAQPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH0</accession>
    <name>K0IJH0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosome maturation protein SDO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c23880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23880"/>
    <dbReference type="EnsemblBacteria" id="AFU59313">
        <property type="protein sequence ID" value="AFU59313"/>
        <property type="gene ID" value="Ngar_c23880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2360"/>
    <dbReference type="HOGENOM" id="CLU_043216_2_0_2"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2386-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="228" mass="25347" checksum="A7B55FC51B6FBA0F" modified="2012-11-28" version="1">MTDKFTVARLTLDGDKFELLVKPDPALEYKLGKRADISSVLVSDEIYSDANKGSRASSEKMMKHFKTTDAAEVAKQILARGELNLTTDQRRKMVEEKKKQIVQFINKSFVDPKTHLPHPIIRIEAAMDEARVIIDPFKKADDQAKTVVDALRKILPLKSETAKLTVTVPPQFAAQSYSVLKSTGDLRSEEWLSDGSLRAVLEMNASLKGQFLDRLGSVTKGSAQVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL1</accession>
    <name>K0IJL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60220">
        <property type="protein sequence ID" value="AFU60220"/>
        <property type="gene ID" value="Ngar_c33050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33050"/>
    <dbReference type="HOGENOM" id="CLU_2613761_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3305-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9069" checksum="54F5F91BDC15B3FF" modified="2012-11-28" version="1">MGEFNSGFTAGATLGREQLFQHIRRFKNAGIYGWQLWKLDYRFDSNIPTFNLAQTINNRIKFAEPFYHLAEAISTIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL5</accession>
    <name>K0IJL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59393">
        <property type="protein sequence ID" value="AFU59393"/>
        <property type="gene ID" value="Ngar_c24690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24690"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2445"/>
    <dbReference type="HOGENOM" id="CLU_086031_0_1_2"/>
    <dbReference type="OMA" id="LFNGKYD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2467-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="24071" checksum="00C5F2D7D3D5EB71" modified="2012-11-28" version="1">MIAGFLSRVRANDKEIIDKLEMQNANLLKATSALVELISNFDNVNERKAKIKDLEHEGDRITHDLYMLLDRTFVTPLDREDISSLTGVVDGILDYTDETAERFVPFKIKEPTSYMLELAKILLSASQEVHLPMTRLRGFKNSADLVEHCRNISKYEHEADTIYRTAIAELLETSNPFEIIKLKEVYETLEVALDKCADVADVFEDIALKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ8</accession>
    <name>K0IJQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33950"/>
    <dbReference type="EnsemblBacteria" id="AFU60310">
        <property type="protein sequence ID" value="AFU60310"/>
        <property type="gene ID" value="Ngar_c33950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33950"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3396-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="15780" checksum="5F38191B151279C7" modified="2012-11-28" version="1">MSPSVLLVDDESDIITSTFSALRRAGFTVHSFTDPIEAINHIREEGCKDCRLLLSDIRMPKMNGFQLVRTLKELRPEMKVIMMTAFEVDKKEFEIVFPSLPVDTIVKKPFRPSIVAEMIKEIYYSSEGKKIRKQNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT3</accession>
    <name>K0IJT3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmB</name>
        <name evidence="1" type="ordered locus">Ngar_c25610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25610"/>
    <dbReference type="EnsemblBacteria" id="AFU59483">
        <property type="protein sequence ID" value="AFU59483"/>
        <property type="gene ID" value="Ngar_c25610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25610"/>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_2"/>
    <dbReference type="OMA" id="RHGESDI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="23598" checksum="FE972DDC63A2642F" modified="2012-11-28" version="1">MPLVIFMRHGQAENNVSRILVGRHIESHLTSQGRQQVADAAKQLKSIPIDKIYASPVIRAVETAQIVCETLGMDYEIDERLYEIELGKLVGMNYEEVTTKYGDLFLRFYAEHDPVLDSFGVEPFSAVKQRVKNLLDDVLKKYEDSNVLMVTHLDPIKAALATLLDLKPEALYRWHIRNASLTVLKHESKIYSLSGVNVMAMHRYPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJV8</accession>
    <name>K0IJV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59508">
        <property type="protein sequence ID" value="AFU59508"/>
        <property type="gene ID" value="Ngar_c25860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25860"/>
    <dbReference type="HOGENOM" id="CLU_3094231_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2586-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5806" checksum="215BC8F5EF8B8FA5" modified="2012-11-28" version="1">MSLLIEEEEQQETEGVPVCGANLSSPVVDTAYYIDEIHYRIGNRMYIENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKA1</accession>
    <name>K0IKA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58752">
        <property type="protein sequence ID" value="AFU58752"/>
        <property type="gene ID" value="Ngar_c18190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18190"/>
    <dbReference type="HOGENOM" id="CLU_1375469_0_0_2"/>
    <dbReference type="OMA" id="HAENFGM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1817-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="210" mass="25264" checksum="56512B35A91AB5FE" modified="2012-11-28" version="1">MAIIRTKTAEPALKADKLFFIYVAKNKEWQQRQQEDWGYVSSMSRFFKWWAQRYFDVELPVEADILPVIPGKLFDRMSLAYLVRDHSERGNDIYHFYLAYFKPFWTDCNTEGYTAENIGMAWWQRPDSGVSETERYVFYADNNCPRVSHVLAHELLRMKGKTKKDYFGKVHDLWDKHVYKDKPFLYFDSRFKRVRKDDSYRFATLDPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKB0</accession>
    <name>K0IKB0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupredoxin_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58782">
        <property type="protein sequence ID" value="AFU58782"/>
        <property type="gene ID" value="Ngar_c18490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18490"/>
    <dbReference type="HOGENOM" id="CLU_1933325_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1847-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14291" checksum="1470E05915936A09" modified="2012-11-28" version="1">MRNNIIAIVAISFLTMGALWGIGNLLNPPPEVELPVEDILLIAQRSTFNGTNPDIHVAVNVPTKLVVRNDDVVTHDLRVDEAENGGITPINTAPLRGGQDFLTAIVAAEPGTYEYYCWYHPEMRGRIIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF2</accession>
    <name>K0IKF2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58887">
        <property type="protein sequence ID" value="AFU58887"/>
        <property type="gene ID" value="Ngar_c19550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19550"/>
    <dbReference type="HOGENOM" id="CLU_2340284_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1953-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11478" checksum="7C7638F92429200D" modified="2012-11-28" version="1">MAVKNMNYDDDGDDGKRNGNGGYDEILCKMWIDAATTETNFAVNTAVRKYRNSKEQIDYLVTLDSILLRYQEIVTKTVAEHGRQAQAIAEEISGLAAAGGDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF9</accession>
    <name>K0IKF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58902">
        <property type="protein sequence ID" value="AFU58902"/>
        <property type="gene ID" value="Ngar_c19700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19700"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_2"/>
    <dbReference type="OMA" id="YHPEVPP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1968-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="13172" checksum="76091DCD4CCB9E18" modified="2012-11-28" version="1">MEGVIDIISKKWALLIINEIGNHRRIRYNDLMKEIEGISPKTLADTLKELAKYNLVKREAFNEIPPRVDYTLTEDGKELREAIIPILRWALTKKGTVVAHCSCTLIERGKKIEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK1</accession>
    <name>K0IKK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Archaeal thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thsA2</name>
        <name evidence="5" type="ordered locus">Ngar_c20600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20600"/>
    <dbReference type="EnsemblBacteria" id="AFU58992">
        <property type="protein sequence ID" value="AFU58992"/>
        <property type="gene ID" value="Ngar_c20600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2036"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="AKXLVEL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="531" mass="57669" checksum="5A4694AB3F6F0F0B" modified="2012-11-28" version="1">MKEGTSQTKGRDAIRNNVEAAKLVAAILKPVLGPRGMDKMLVDSLGDVTITNDGATILKEMDVQHPAAKIMVEIAKTVDEEVGDGTTSSVIIAGAMLEKAEELLIKKGIHPTIIVDGYRKAMRMSIEILNKIAEDVNINDHAVLKDIAKTSMESKIVSVDSDVLADLAVKAILTVAEKADGANGDNYMVADLDNVKVQKKAGESMGESSLIEGIIVDKEITHSEMPKRIENARILLLNSGLEIEKTEFDAKISIDRPEQMKMFLEEETRMIKAMVDKIAAVKANVVFCQKGIDDIGLHYLTKANISAVRRVKESDLDALAKATGARVVTNIDDLSPDDLGYAQLVEEKKVELDKWVFVEKCRNPKAVSVLIRGGSQRIVDEAERSIHDALMVVKDVVQKPAIVVGGGSPEAYVAQRLREWAPSVSGREHFAILAFADAIESIPVTLIENAGMDTIDTITQIRSKQSATSLWMGVDVKEMKVTDMRKKNVIEPLAVKEQVLKSATEAAAMLLRIDDILAASPTPAAGQSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKL9</accession>
    <name>K0IKL9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF59 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21010"/>
    <dbReference type="EnsemblBacteria" id="AFU59032">
        <property type="protein sequence ID" value="AFU59032"/>
        <property type="gene ID" value="Ngar_c21010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21010"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2081"/>
    <dbReference type="HOGENOM" id="CLU_091588_3_0_2"/>
    <dbReference type="OMA" id="HLTSPFC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2099-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13333" checksum="CA3F1EF041CBFF87" modified="2012-11-28" version="1">MSQEEQLQQTRRKIFDELTKIVDPEIGVSIMELELVDKVDINSGKVNVDLHLTSPFCPAVFGFKIAQDVRDNIYKLPGINEVKVNVSNHFMADAINKQVNESKYPAKPAESNKPSSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM8</accession>
    <name>K0IKM8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system-like protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29350"/>
    <dbReference type="EnsemblBacteria" id="AFU59853">
        <property type="protein sequence ID" value="AFU59853"/>
        <property type="gene ID" value="Ngar_c29350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29350"/>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="YHDNWLS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2935-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="178"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="555" mass="62886" checksum="6029707C6CAC028C" modified="2012-11-28" version="1">MTALRSFKIKLSNENKKKEDDDFITAFKESSFEETGLNAQLDKVAKYIDSISRSDASLGKVPEGYKNIQRYALVPPFCYVSILQNSEFSDIIYNVDELQLNEEEIKIYYSIKELLEKQIDSPRLLDNLEASFTAEVTRLLKEHFMGGKAQPVMLEKVKYYLKRDILGFGPIDPLFHDPFIEDITCGGPNKPIYVYHRRYEGLRTNIVFRDSEFLDGFVMKMVHRAGKHISAAHPIVDASLPGNHRLAALYKKEVTTMGSSFTIRKFREDPITIVDLINSDTLDIDIAAYIWFLLDNKKSLMVIGSTGGGKTTILNAVTGLINPSYKIFSVEDTAEINIPHENWFSLVSRASFGLESQGEVSLFDLLKSGMRHRPDYILVGEIRGEEAYVLFQALATGHGGMATMHADDSAAAIRRLMQKPMDIPQSYVPLMNCIINIKRVKLKSEQISGKAATRMMARRVTEVTEILPSSTPKSVFSWDPQYDGYLDSLKNSYQLPKIAEDTGLDMQDVANELSKRKTILTWLVNRGTRDYRSISKVIGMFNQEPERLMKKVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL56</accession>
    <name>K0IL56_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59337">
        <property type="protein sequence ID" value="AFU59337"/>
        <property type="gene ID" value="Ngar_c24120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24120"/>
    <dbReference type="HOGENOM" id="CLU_1145260_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2410-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="294" mass="31353" checksum="3C8E0B1D656A661C" modified="2012-11-28" version="1">MIGREVSRQKVVAAASIAAAAIVLAIFVAATLPDRGDTTVATNNSSAAGQQQDDDNNNSTEQIRNIIYNVKFECGTISGDEGPLRPGHYDTDIGIFNKQDFAVKVQWSATANDSRNTNSILRTLQPQSVTGIVCKDLRQILGNNQSFVEGYVIINVPVEQGLLGSLSGGSTVLGRSSDDINILEVQAFYTANALAELPHPVLVDKITFAITNDTSGKIPADMIGKTLDITVPSEMNEISDPEAKVRNVLAEKYALSEQELVGLQIEVRDIGIGVGTMIDDHAISLSKITPQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL85</accession>
    <name>K0IL85_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60228">
        <property type="protein sequence ID" value="AFU60228"/>
        <property type="gene ID" value="Ngar_c33130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33130"/>
    <dbReference type="HOGENOM" id="CLU_113981_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3313-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="19117" checksum="EC0ABD4D28BCEDB6" modified="2012-11-28" version="1">MTAQQKHSISNDNIANELKITPAIIEQALQFDLGPEAKKLVIQCIQQKYGMDFELVGQYKTEFENYLRELLHESAEVIIARIESAIEDSKRRALTMSTTTPPSSKRLSDTVHFLFCDQCYWSASLLTTTFELKCMSCNSELKCALPISSNEAFRYEINSKRGLALFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL92</accession>
    <name>K0IL92_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59372">
        <property type="protein sequence ID" value="AFU59372"/>
        <property type="gene ID" value="Ngar_c24480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24480"/>
    <dbReference type="HOGENOM" id="CLU_159725_1_2_2"/>
    <dbReference type="OMA" id="MLEIGMG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2446-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11026" checksum="903BEAB7254F2067" modified="2012-11-28" version="1">MLEIGMGDVYRNSVKIVGDVLRIADESGTGGVNLTALLRKANLSYSRLANVALKLMEAGLIDEQVQEGQRIYTITSRGRDYLRRYQQFAEIADSFGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL94</accession>
    <name>K0IL94_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56959">
        <property type="protein sequence ID" value="AFU56959"/>
        <property type="gene ID" value="Ngar_c00090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00090"/>
    <dbReference type="HOGENOM" id="CLU_2875194_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-9-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7180" checksum="FA8510E84E0DB069" modified="2012-11-28" version="1">MIGVHQRSVEVFDSPITRKQTYTSLPRPIQCARCNHLAYCKVMYDLGQVIKVEFLCKACCEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL95</accession>
    <name>K0IL95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ChaB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59377">
        <property type="protein sequence ID" value="AFU59377"/>
        <property type="gene ID" value="Ngar_c24530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24530"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2427"/>
    <dbReference type="HOGENOM" id="CLU_2327345_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2451-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11145" checksum="FDDB130CE0C2CDD8" modified="2012-11-28" version="1">MARGRSTTGRKTTKRRSSSRARNGAGLSPRTRKAIETLPTHAQQIYRKAHKNALKQYKSPSKRRGGGRQSREQVAHKVAWSAVRKAGYRKEGSRWEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA3</accession>
    <name>K0ILA3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic-acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00190"/>
    <dbReference type="EnsemblBacteria" id="AFU56969">
        <property type="protein sequence ID" value="AFU56969"/>
        <property type="gene ID" value="Ngar_c00190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00190"/>
    <dbReference type="HOGENOM" id="CLU_165225_0_0_2"/>
    <dbReference type="OMA" id="THKCTEC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-19-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14146" checksum="531396EE4358E209" modified="2012-11-28" version="1">MMEKLSSTESTHQRFIEAANRKKILAHKCVKCGHMMLETVLFCEKCSGSKFKHVELEGAGTVVTYTIQAVAPEGFEDAGSYAWVVFKVDNSQLRASGFLPGIKVPADLPIGTKVRVAGFDSKHGLMLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB5</accession>
    <name>K0ILB5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsZ3</name>
        <name evidence="5" type="synonym">ftsZ</name>
        <name evidence="8" type="ordered locus">Ngar_c33830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33830"/>
    <dbReference type="EnsemblBacteria" id="AFU60298">
        <property type="protein sequence ID" value="AFU60298"/>
        <property type="gene ID" value="Ngar_c33830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3376"/>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_2"/>
    <dbReference type="OMA" id="IMNQGGV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="347" mass="37174" checksum="F0F489832F70EED5" modified="2012-11-28" version="1">MEEESIRAAMEMAKPTVCVIGAGGAGSNIVSWIKERGLSGGKLIAVNTDAAHLGITRADRRILIGPKITQGRGCGGYPEKGMQAARESMSEIVREVQGSNIIFLCAGLGGGTGTGAIQILADELKQETQALIIGVVTLPFAVERYRYDLAKEALDNLQRSCDTLVTIDNNKLTRLAGNLPLQQALGVANELVGQFIKGITETITTASLINIDFADLTAIMEGRGLAAIGVGLSEGMERIEQATRMALETQLLDIKDMSMASGVLVHVCGGDDITLEEVTRAGELVTRSLPHEVRIIWGARIDPSLRGKARVMVVLTGVDTNFIGASKQQEQQVAEAPEQKPKRRWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC1</accession>
    <name>K0ILC1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56994">
        <property type="protein sequence ID" value="AFU56994"/>
        <property type="gene ID" value="Ngar_c00440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00440"/>
    <dbReference type="HOGENOM" id="CLU_203621_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-44-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8883" checksum="DBADDD9F818B72F3" modified="2012-11-28" version="1">MSEDTAEEKFFRENYAQELQRIKHDRELEEERKKVKQQAMKTPGRRGEQIKHEEIDREIIRRYRLKTTKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD3</accession>
    <name>K0ILD3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25140"/>
    <dbReference type="EnsemblBacteria" id="AFU59437">
        <property type="protein sequence ID" value="AFU59437"/>
        <property type="gene ID" value="Ngar_c25140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2492"/>
    <dbReference type="HOGENOM" id="CLU_063034_1_0_2"/>
    <dbReference type="OMA" id="CGHCHIP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2513-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="253" mass="28874" checksum="815CF6B6457077E9" modified="2012-11-28" version="1">MAALQIVQLSDIHIGSLFVQNVFDTVVDEVNKLKPDAIIVTGDLTDEGLLFQFERARNELKRFTCPNVIVVAGNHDYRHTGYLLFKKFFPSKQIYEFDDAIVLTLGTARPDRDEGEVGYRQNQWMEKTLTKLPETKPKIVAMHHHLIGIPDTGTDKIIILDAGDTLRTCLQSGVDLVLCGHKHRPWVWNLGRLEIAYAGTTSSSRFRGFFENCYNIIDIEMGKKPRVDIKIVGKKRFPLAELVERYKPFLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU5</accession>
    <name>K0ILU5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59677">
        <property type="protein sequence ID" value="AFU59677"/>
        <property type="gene ID" value="Ngar_c27560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27560"/>
    <dbReference type="HOGENOM" id="CLU_032903_4_3_2"/>
    <dbReference type="OMA" id="EDTIETC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2756-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="18291" checksum="E3440CC62D0466EE" modified="2012-11-28" version="1">MTKRTYKFRLYPTEEQVKKLEDTIETCRHLYNDSLGERRVDWDVGFYEQKQLLTLRKQDSKYLKQVHSQVLQDVILRLDKAYQAFFKKLAKYPKFKRKDKYNSFTYPQYNNGWKIKDNNKLVLSCIGSIKIKMHRIPIGTLKSCTIVRDVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY0</accession>
    <name>K0ILY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nudF1</name>
        <name evidence="3" type="ordered locus">Ngar_c04850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04850"/>
    <dbReference type="EnsemblBacteria" id="AFU57429">
        <property type="protein sequence ID" value="AFU57429"/>
        <property type="gene ID" value="Ngar_c04850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04850"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.463"/>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_2"/>
    <dbReference type="OMA" id="QWIYTHG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="21828" checksum="0BAF33003BAC967E" modified="2012-11-28" version="1">MKKGWECLETKEVFKAGDGKTVYIELYQDRVRTPKGNVLTYTKYHASDVVIVVPFIDRQTLLMIRQFRYPIGKVLLEFPAGHVENKEDPLDTAKRELEEETGYRARKVEYVYSYHPAVSRTRQSVHIFRATDLARASATKHDGGEQISMRKVTVKQLRQLITKRKVENAGTLIAYLLCCTMKTSSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC1</accession>
    <name>K0IMC1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nth</name>
        <name evidence="7" type="ordered locus">Ngar_c08120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08120"/>
    <dbReference type="EnsemblBacteria" id="AFU57754">
        <property type="protein sequence ID" value="AFU57754"/>
        <property type="gene ID" value="Ngar_c08120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.777"/>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_2"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="25055" checksum="A0502552B475C60E" modified="2012-11-28" version="1">MGVIIKKMEQALNREKPPRLTALRGLQMEEQGDPFKILIGTILSARTRDENTTRVVNKLFARFKTPQDLASADIDEIKKIIHSIGFYNIKAERIKQVSQMLISKFGGRVPSDIDSLLKLPGVGRKTANCVLVYAFDKPAIPVDVHVHRISNRLGLVSTKTPEQTEQDLSKLVDRKLWTKVNDTFVMYGQNICLPVRPNCKACDLKKMCRYYSSSSSTTLASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG0</accession>
    <name>K0IMG0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60242">
        <property type="protein sequence ID" value="AFU60242"/>
        <property type="gene ID" value="Ngar_c33270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33270"/>
    <dbReference type="HOGENOM" id="CLU_198710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3327-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7318" checksum="BF7FE57896607E41" modified="2012-11-28" version="1">MHKSARTDDGQPIGYIAADDEESIIVLASRFREYNIPKLHVKAFDGSQIYLDFASNELEQYRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM4</accession>
    <name>K0IMM4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acsA2</name>
        <name evidence="4" type="ordered locus">Ngar_c34990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34990"/>
    <dbReference type="EnsemblBacteria" id="AFU60412">
        <property type="protein sequence ID" value="AFU60412"/>
        <property type="gene ID" value="Ngar_c34990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3502"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="DFYTEYD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="92"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="516"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="632" mass="69567" checksum="B3A6AA43523A767B" modified="2012-11-28" version="1">MPAEEKYVFTPLPELMAKSNIARFMNRHGISGWRQLVEKANSDIGWYWDAVNEDLSIDWFQRYDKTFDSSAGIPWTKWFVNGKCNIVANAVDKHAKSQPDKVAYIFADEHGSKKITYGELDEQVSRLAGALAGAGIKKGDVVAIYMPMIPEAFYAIFACSKMGAVHTTIFSGFSAQALRSRLIDSNAKLLITADTVSRRGKEIHLAGQWQKAVQGTKVRRIITVGRDYQDFVKSAPRAKTEVMDAEDPLFILYTSGTTGEPKGTLQVHGGFTVVAAQQTAYLIDMKPDDVLFWYADIGWITGQVWVVYGSPIIGGTALVYDNTLDYPTADAWCRLIEDHKVSIFGAAPTAIRLFMKKNVQAGNYDFSSLRVLAATGEPINAEAWQWYFENVGKKRCPVINLSGGTEIGGAILSALPVMPLKECTVGCQIPGFDADVFDDSGKRASEGYLVIKKPWPSMTRGLLNNPGRFIDTYWSKYKDVWYHGDIVLVDPDGLWYMRGRADDVIKVAGHRIGTAEVEAAAASHPAVAEAVAVGRPDELKGEAIVVCVVVKDDGSHSTNGNNNNNLKQEIIRCVEGSIGKFARPEEVRIVAELPKTRTGKLVRRLVRAKVAGENIASQDLSTVENPWSLDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN9</accession>
    <name>K0IMN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.130</ecNumber>
            <ecNumber evidence="9">2.1.1.151</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobI</name>
        <name evidence="9" type="ordered locus">Ngar_c35340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.130" evidence="9"/>
    <dbReference type="EC" id="2.1.1.151" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35340"/>
    <dbReference type="EnsemblBacteria" id="AFU60447">
        <property type="protein sequence ID" value="AFU60447"/>
        <property type="gene ID" value="Ngar_c35340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35340"/>
    <dbReference type="HOGENOM" id="CLU_076014_2_1_2"/>
    <dbReference type="OMA" id="MEYPVTT"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043781">
        <property type="term" value="F:cobalt-factor II C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="30048" checksum="56F1B91B7BECEB78" modified="2012-11-28" version="1">MPHQGDQDNRPLHGRTTVPVVDLNCRERVQQPMKLFCVGCGPGDPELLTVRAVNLIKSAEVVFAPTAREGKSSIALSVVEKYVSKTAKTASLVFPMVKDKESLKDYWKRNADDIAAAVRSGKKVVYLTVGDPALYSTWIYVHRELKRNHKDIEVEIVPGIASMFAIAAKAGISLAEGEETVAIVPACYDMDRVRRTAAACDTVIFLKDGRYFDSVIEMLGESGFPDNANIAIAQDVSDEGEILDVKKLSELRGKKGPTEKYFSIMVAKKNARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR5</accession>
    <name>K0IMR5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60512">
        <property type="protein sequence ID" value="AFU60512"/>
        <property type="gene ID" value="Ngar_c35990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35990"/>
    <dbReference type="HOGENOM" id="CLU_2044521_0_0_2"/>
    <dbReference type="OMA" id="FRYTMIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3600-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="15579" checksum="3C053BC73B92FB1F" modified="2012-11-28" version="1">MLLLPKFLFRGAIQICIALMADSKSNSNNLYAHLVANSLFTPRQLSIISKRLQGGGRAQDISSGAYYRQVKQCRDKVNAVLYSMILLQSTGVVQPETLSAIGRLAEQLSVIFASESSDVASRLSVDDVISVMDQLVKRMSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT2</accession>
    <name>K0IMT2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58169">
        <property type="protein sequence ID" value="AFU58169"/>
        <property type="gene ID" value="Ngar_c12290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1179"/>
    <dbReference type="HOGENOM" id="CLU_535985_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1227-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="534" mass="59374" checksum="43377AA65F74F1DE" modified="2012-11-28" version="1">MRIHSLASIIMAAILVTSIAAAAVAVVPAFAQEQQAESKGDSWNTINTLLGEVEKLTGKNATATQTALEKLEQAKAKYEQVFAHEAEEHAPETAQLIETAYANMQAAVESSTVLEVTLNKQYADKLIYKIAFIKIEEELLEEKVEEAAEWFTVMTKKFKYDQTPSEASEAMAELEADPSKIAKLSPVILDDLRATFLLKVKEEITEAIEAQSKQPPDNANAQKFAIEGIAYYYTIQPDVRKKLGAEQEATLFHELEEFSEYAQDGNLIKMQEEAEEINTLLLAYEGKETTGIGAAISRMIDLLQLVTIEYSAAVSNGQIIDQEEYDETVLFLSQATETFNQNKAELMEIAEHETQEVEADLANLKTMVEGLEDPTEVADTVAHAQHELEEILGATGGTVEEKGGWEYIDTVKLLLDEVVVEYKAGNYEQARTLARNEAYLNNYEFIEPDIAEDNPELMVKIELAIREELVKMIDDRRPAAEIEAHVEEIKTDLEVARAVVTPEFPLAVIVLASVAVTILAGTLYTRRTRVLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ4</accession>
    <name>K0IMZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hydroxymethylpyrimidine transporter CytX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cytX</name>
        <name evidence="7" type="ordered locus">Ngar_c15450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15450"/>
    <dbReference type="EnsemblBacteria" id="AFU58479">
        <property type="protein sequence ID" value="AFU58479"/>
        <property type="gene ID" value="Ngar_c15450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1510"/>
    <dbReference type="HOGENOM" id="CLU_048240_1_1_2"/>
    <dbReference type="OMA" id="NTIYNFA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="434" mass="46904" checksum="215C256BC0064F27" modified="2012-11-28" version="1">MALFKTPEWGVKPVEDRHKMLGGFDYFILWSSLGVGLLVFSAGSFLSAASFVDATLAIIIGSAAGSILLALAGKIGSDYGIPSLISMRPSFGIRGSYLPAILNVMQLVGWTTFEIMIMARAAEMLAGSVMPYYFWAAIFGALVALLGIAGPLNVVRKWIGKFAVWIAYGTSAIIIINLINSADIAALVVSPGEGMSFFSALDLVIAMPISWLPLVADYNRFAKKSKSALWGTFVGFTMTNILFYFGGLLIGTPDVIEIVIAIQAMFFGFLMLLLIVDEADNAFADVYSAAVSTQDIFAKINQKYLVIGFTALSAVLAMVVSIQDYEVFLLLIGAIFVPLFGVVLTDYYIIRRQKYTEQMLYARQNWLGIGVPAIIAWALGALVNYMLSPLSPIYQEQLPATGATIPSLAAASLIYIAITRMQPQANKTVASSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN58</accession>
    <name>K0IN58_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative arginase/agmatinase/formiminoglutamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18670"/>
    <dbReference type="EnsemblBacteria" id="AFU58799">
        <property type="protein sequence ID" value="AFU58799"/>
        <property type="gene ID" value="Ngar_c18670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18670"/>
    <dbReference type="HOGENOM" id="CLU_2565857_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1865-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="8560" checksum="18BFC0D888562766" modified="2012-11-28" version="1">MESKVFGFTDVDVLNDKDMPAVDYRLSGGLSYGDISQLLQILLGTGKAVGMDIAIFNPKLDSDGSIARRLVSSLASGLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN75</accession>
    <name>K0IN75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58884">
        <property type="protein sequence ID" value="AFU58884"/>
        <property type="gene ID" value="Ngar_c19520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19520"/>
    <dbReference type="HOGENOM" id="CLU_1551874_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1950-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="19735" checksum="206BA3BE6F7D059B" modified="2012-11-28" version="1">MTSNNKTVFNNDDGKNKEKKKLKEIPAIRSINGKLVPVIEVYESFTGWYWFVTERTPDRDNPDECFGLVIGLEKEWGYIDPPAIKAELGSLFWKVHQRDVWSISHIEMVKVEDCAGNSGNDVCPLCNELVTEYQTRYIENERIVHEKCTSDDADNDDVKNADGRMSDNQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND3</accession>
    <name>K0IND3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c22440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59174">
        <property type="protein sequence ID" value="AFU59174"/>
        <property type="gene ID" value="Ngar_c22440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22440"/>
    <dbReference type="HOGENOM" id="CLU_1154380_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2242-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_45" evidence="3">
        <location>
            <begin position="155"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="229" mass="25351" checksum="642CA2A7E2A1C2B5" modified="2012-11-28" version="1">MLSAKLAIDIIFIGLVVVAILITAIVVAKAMTDKFSIYTNSAQQAQTNNNDNNLEESGDTKVRPTLPHLDAQPKQDQSFELSITDAQTATASPTDQIAASIYGSSPIILPITWGTVAGTLIWRGKVRSTWSKQGYDYDTFKLLTRMRGSPMRIRLLNAINSSPKNKLQLAKELDVDWKTIDNHIEMLLHSRLVEERTVVGTARYYAITHDGIKVLSLLSNSSEMTDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF5</accession>
    <name>K0INF5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="2">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">coaD</name>
        <name evidence="4" type="ordered locus">Ngar_c23590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23590"/>
    <dbReference type="EnsemblBacteria" id="AFU59284">
        <property type="protein sequence ID" value="AFU59284"/>
        <property type="gene ID" value="Ngar_c23590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23590"/>
    <dbReference type="HOGENOM" id="CLU_035272_5_0_2"/>
    <dbReference type="OMA" id="PIHNGHR"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="17068" checksum="8A9973827C87DAA2" modified="2012-11-28" version="1">MAEKFAVVATGGTFDEIHVGHIALLSRAFQAGRKVIIGVSSDEFAKKRGKRLNHNFDQRVKNLKEMIKKEFGDASYEIAKLDGDFGPAVTTGDVGALVASSETQSKGDLLNEMRAKGGLKPVEVIAVELVKAEDGSPISSTRIRAGEIDSRGKLLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING5</accession>
    <name>K0ING5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59334">
        <property type="protein sequence ID" value="AFU59334"/>
        <property type="gene ID" value="Ngar_c24090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24090"/>
    <dbReference type="HOGENOM" id="CLU_1821076_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2407-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14467" checksum="E19FC7CB1944CF64" modified="2012-11-28" version="1">MGQEERDFLQKLCDSILNSDKAVRFAGVINNEGKLLIGRYRADIPVPLIKANTEGDTKATSFYSAYQALAINKKFEPDLGQIRFQMTEFDKVTLVSVPLTATNDRFLCISVDAPTYHERVIPKILDIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH9</accession>
    <name>K0INH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59404">
        <property type="protein sequence ID" value="AFU59404"/>
        <property type="gene ID" value="Ngar_c24820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24820"/>
    <dbReference type="HOGENOM" id="CLU_800774_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2480-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="304" mass="35076" checksum="8D7725CD929AD394" modified="2012-11-28" version="1">MINNSEQILAGDIRQLLVIKSEELLRRGEPRFVEGLDEIAGMLGRYDPAPSPLLNALDHKAQDMATYFFVAYSNTRDLDRSILIYRTVKSLVRYVLLIDRFYEVGNKKYERVARGVLRSVKKVQSSHLKYSLDFLLKRSWPFMDYEQAVKRLLIKDHIFNFKEIRHYSLFKASDAPMIYAHVLDAELPDFNQNVAAVLHYNQALQDLHDDFEDIEEDVHDMMPNMFILAATGAAAITFSKLLKNREHARKMVIESGALDSMVPLVEQYRAMVKGISVPPSFAFLKYLTKEYADMMLRALDVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ3</accession>
    <name>K0INJ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59474">
        <property type="protein sequence ID" value="AFU59474"/>
        <property type="gene ID" value="Ngar_c25520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2529"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2551-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="12182" checksum="D7C675AB381C45DB" modified="2012-11-28" version="1">MLILRNMIYSKQKHFNEFLNSIEGINLNTLSTRLREMEKNQLIERRIFHEIPVRIEYTLTEKGKDLIPIIEQMGAFSMKHAPEIFKNSKASSFQELCGRDPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK1</accession>
    <name>K0INK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative inosine-uridine preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c25920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25920"/>
    <dbReference type="EnsemblBacteria" id="AFU59514">
        <property type="protein sequence ID" value="AFU59514"/>
        <property type="gene ID" value="Ngar_c25920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2564"/>
    <dbReference type="HOGENOM" id="CLU_036838_2_1_2"/>
    <dbReference type="OMA" id="HAPDIHG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2592-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="323" mass="35497" checksum="07A177E377355991" modified="2012-11-28" version="1">MSGKKIIIMDVDTGIDDAIAIIVALQSPNIEIIGITSVHGNVSSKKAALNTLGILQAVGRQQHANKIPVIQGALRPLSSGKKLVHTEHIHGKSGLGDIKLEYDESLLRRDGAPHFISQTLKNYRKGEVSLIATGPLTNVAKAIAADPSIVDSLSGIYVMGGAYGLASKDVYGNITPYAEFNFYCDPAAAQIVMDSGAKMNVVGLDTTKRYLVDDTFVARLLRSRKNKAAKITSSLLHYPIERFGKFDLPDVFAVAMLERPDMFEFKKGRIEVVKEGPLQGHSRFIEEAERANNSKTFVVSRIVSERHFDDYLFSRLGSNHYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR1</accession>
    <name>K0INR1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c28950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28950"/>
    <dbReference type="EnsemblBacteria" id="AFU59814">
        <property type="protein sequence ID" value="AFU59814"/>
        <property type="gene ID" value="Ngar_c28950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2872"/>
    <dbReference type="HOGENOM" id="CLU_032707_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2895-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="121"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="469" mass="51420" checksum="050A4A0085E199C7" modified="2012-11-28" version="1">MGWRYYGKKSKKLVISAALASALVMAGIAAALVSIAGAITAAGNGDDDHMHAAAREEKTTIHYTLIAQETTLEIAPDVRVPAWTYNGTIPGPTLRATEGDRVVLHFINETPLPHTIHLHGDHDEQDDGVFQEVQPNGTYTYDFVAGPAGALMYHCHVMPVSQHIRMGLYGAFIVDPETPLPPAREYVIVTGEYDTENQMTDQPEYILFNGYADQYWNNPLPARTNETVRIYYVNLGGSPAFGFHIHGTIFDTYPSGILENQPLKVQTWEVGAGNAAIFEARWPWEGRYLFHLHGMPEEKGTMAYFDVTDAGVDAVDGVDVARSKSIDMVPWQNKLIKDLQKADAGGKVSFSPAAGGNERVGHHGLPAAEDAGSESTETTEILISQDSGVRSSGNTFTPETVLARTGDTITWTNNDSIPHTVDSTDGTFSSGYIMKGQSFKYTFTEAGTYEYYCTLHPWMEGTVQVEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT5</accession>
    <name>K0INT5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59934">
        <property type="protein sequence ID" value="AFU59934"/>
        <property type="gene ID" value="Ngar_c30180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30180"/>
    <dbReference type="HOGENOM" id="CLU_2177966_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3018-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12653" checksum="D9C9FDB090EAF153" modified="2012-11-28" version="1">MHAGWQWQQRRRRWSWVQIPPGPLHFQIRIRDILLCLDDDNAGKRCQKELQSLADPEKAAVLQRFFKAGQGQYGEGDVFLGVVVPKSREVARKFSQLPLEEVKALLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW3</accession>
    <name>K0INW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60074">
        <property type="protein sequence ID" value="AFU60074"/>
        <property type="gene ID" value="Ngar_c31580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31580"/>
    <dbReference type="HOGENOM" id="CLU_186530_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3158-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10278" checksum="F014C5159355DB7F" modified="2012-11-28" version="1">MRTSNNETSSGAAAIETEDRDIELENIIGNLLIAEYQVDKLRNRLVDKISPSYSSAGAKDHSAYSFKIGSKWYRVSIKVEEQRLALETAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP21</accession>
    <name>K0IP21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60364">
        <property type="protein sequence ID" value="AFU60364"/>
        <property type="gene ID" value="Ngar_c34490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3447"/>
    <dbReference type="HOGENOM" id="CLU_1718125_0_0_2"/>
    <dbReference type="OMA" id="EGANDMQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3450-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="14183" checksum="925146F23F626DF3" modified="2012-11-28" version="1">MFVLLARSQGGFGFIFLAAASGLMIYWVREVRMMARSEERKMAKEIEQQKDWVYDLIKGNDEVVFVAEVPGPEDQINVRLIGDLLRIKGGQNFARDVPLELTQEMGIADYKYRNGVLTIKIQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP35</accession>
    <name>K0IP35_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35210"/>
    <dbReference type="EnsemblBacteria" id="AFU60434">
        <property type="protein sequence ID" value="AFU60434"/>
        <property type="gene ID" value="Ngar_c35210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35210"/>
    <dbReference type="HOGENOM" id="CLU_1399785_0_0_2"/>
    <dbReference type="OMA" id="RHEEYEG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3522-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="203" mass="22292" checksum="3E8ABFEE1E931AD2" modified="2012-11-28" version="1">MSSTAEAQNRGEMDAGDDSNSGGHLALKDVYKLLKKEIETPLLQAIEPDTFQKIAAALGNLRGQGYEGVEAKVRDRMAELLASSAQLLIEARQAKIRSGGEPLDYSKLTDEEKYVLDGRRESESRIDEVVAATIKGRPKVLESISARMRSKQIVVRFLRPTEAFVGVDMNKYGPFQQEDVASLPFENARSIIEGGAAVEVHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6W3</accession>
    <name>K0I6W3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56996">
        <property type="protein sequence ID" value="AFU56996"/>
        <property type="gene ID" value="Ngar_c00460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00460"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.52"/>
    <dbReference type="HOGENOM" id="CLU_747258_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-46-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="370" mass="41245" checksum="A5C96FEB5A5173AC" modified="2012-11-28" version="1">MAKHGWRILVTMTIALGVLLPAMMASGTSVNDTDVEEPIWKTWTVVTRGQSYPIQYSITSGSSIVNMVPDVETLTLTITISSTADGKLTIELPRELIDSREGPNQTGADNEFAVFVDDENVALDEIEATNTTRTLVIDFRRGTETIEIVATWLPMYQPPPLNEWQTTNIVGRFLYSDPPKPDQIFKVQYRVVNGTIEKLSIWQTKVSSNGNGTLEIKFPRNYPYTNQDGINVPITVNPILIVDGQWGDEITYSDITDCFFVFSIPFTDSKSIGLVWSYLATNLPFHGDDVPESCISQTLVENVPTRSDGTISPLKQFKAGVAAEDVVCRQLEGVERKFMLLISPYGEPYCVSLSNEGFMKAKGWTEPLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I715</accession>
    <name>K0I715_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57056">
        <property type="protein sequence ID" value="AFU57056"/>
        <property type="gene ID" value="Ngar_c01060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01060"/>
    <dbReference type="HOGENOM" id="CLU_2257453_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-106-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11499" checksum="8F7DDC060D17FC36" modified="2012-11-28" version="1">MQAEAIEKDIDVRAEGRKEKVFLTTGTLYALATLQALAIGTDLLSFFRDPIEVYGLIIIGFYIANFLYDDLGQQLVELSIRHRHAVASAIKTGLDGFLRRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0I732</accession>
    <name>K0I732_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monovalent cation/proton antiporter-2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c01260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57076">
        <property type="protein sequence ID" value="AFU57076"/>
        <property type="gene ID" value="Ngar_c01260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01260"/>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="OMA" id="PYLWFAK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-126-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="14"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="409" mass="43175" checksum="F114AF24208810B9" modified="2012-11-28" version="1">MVEVFELVIRDFAVIMIVASAMALLSYKLKQPMVIAYIAAGMIIGPHTPPFSLITQIEVLELFAEIGVVLLLFVVGMEFPIEKLRKVGRKASVIAAAEASGTFMAGYAVGQTMGFSFYDSLFVALAISVTSTVIVMRVLEELKMIKAEASSLILGVAIIEDIIIISMLAILQSIASTGDLSFVEIGASVGIVLAFIAGALLLGSKTVPKFIDLIGRTNQQDVLVVAMLGVAFGMAFIAFELGISVAAGAFFAGVLIAESKMHSVSAILATPIRDMFAALFFISIGALMDISLLPLFIIPALILVAVSFAAKFITVWSAARAQGFNKLTSMRAGFGLSASGGELALVTAKGGADVGATSAFLLPMIGAMTIITTFISPYAIKFGWKFAEKWKPQGEEEGTAAQAQDKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8D7</accession>
    <name>K0I8D7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c05980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05980"/>
    <dbReference type="EnsemblBacteria" id="AFU57541">
        <property type="protein sequence ID" value="AFU57541"/>
        <property type="gene ID" value="Ngar_c05980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.571"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="VRWMERI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-596-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="312" mass="34969" checksum="FB164E421313E457" modified="2012-11-28" version="1">MKYLVTGGYGFVGSHLVESLLKDGHEVTVLDNLSNGQLDNLKSIKSDITSYISNVEQLQSSYFKDRFDGIFHLATAPRSSSLKDPMRDIETNCKGMIAVLELARELQAKVVFTSNSGIYGSTSGSNSINENSINNPTTPYDADKLVSEYYCKIYHNIHGVRSAVVRFATVYGERQQVNEKLNWRPLVATFVKNVLNNEEVVINGDGEQTRDLIYVADAVQGVIKAMNSAVDDADIFLISTNTETSVKQVLHHVEDITGLKAKTRFTESLKGDIRRMKYDYSKAKKKLGFEPKFSVRDGIKRLVEYSLENRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I937</accession>
    <name>K0I937_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57826">
        <property type="protein sequence ID" value="AFU57826"/>
        <property type="gene ID" value="Ngar_c08840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08840"/>
    <dbReference type="HOGENOM" id="CLU_2505060_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-882-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9479" checksum="EB32C9A0EB98BD6B" modified="2012-11-28" version="1">MEPGESKNLHLGPFKMEDEGKHRLLLLAESEGLALDYPHPDSFIVYQQSTVQVIIFVAVPLVVAGSGIVGFSLYQRARRRPLPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0I948</accession>
    <name>K0I948_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08990"/>
    <dbReference type="EnsemblBacteria" id="AFU57841">
        <property type="protein sequence ID" value="AFU57841"/>
        <property type="gene ID" value="Ngar_c08990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08990"/>
    <dbReference type="HOGENOM" id="CLU_033536_7_2_2"/>
    <dbReference type="OMA" id="HRILFFW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-897-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="304" mass="33538" checksum="078B0430DB472D1C" modified="2012-11-28" version="1">MKINVDTKILICIPAFNEAKSIGDIVRKAKIYGTEVIVCDDGSVDDTYQIAKTAGATVIRHQNNKGYGVAIKTLFRVAKERNADIMVTLDSDGQHNPDQIPNVIQPILNEGFDIVIGSRFLNDEDRKKVPGYRSFGIKTITRFAQLVSYNNITDAQSGFRAYSKNAISKIDLIEEGMAVSTEILMRAGEKNLSIKEVPVTVNYEVENSSTHNPILHGLGVLATIIRFMSLRHPLAFYGIPGMAFLIISGFYMFSALELFSDTRYVSTNMIIVSVGTAVIGVVLLVTAVILYTIAALLREKIRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0I954</accession>
    <name>K0I954_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c09090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57851">
        <property type="protein sequence ID" value="AFU57851"/>
        <property type="gene ID" value="Ngar_c09090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09090"/>
    <dbReference type="HOGENOM" id="CLU_009583_11_2_2"/>
    <dbReference type="OMA" id="AQDMANL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-907-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="225"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="415" mass="46719" checksum="540338B7279F713C" modified="2012-11-28" version="1">MFNTGLNSSKLNLYKVCILAVNYWPIVPGQGTRHPKVISELLENHCDLTIITTHVDKTKGKSFVVEYEGKKKIIRIPFKRFNGKGFFPRALTYLSFAISCIFAAMYIDKHSLIFSVGPDPPYFSLTTPILSRIKSSRNLALLTDMLPDVAFDVGLVKSKVAKDIIRYFCIQAYRNADHIMVITDKLKTRLIHYGVQPERISVVPLAVDTKTFAPRSADQKLVAELKINNKFIVLYSGSFGQMYDFDLLLEAARSIQEYNSNINFIIRGDGAQKSHIAEKISSLDLKNTVLLGPVDSTDLIVSYINLASICVVPMKDSKSIDMTHPSKIFEFWSCGKPVICTSRGELADLVNRSKAGIAIPPGDKQALVDAILRLYNDQTILNNMSVSARTFVENEFSYHIVREKMLNVIERLHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9E9</accession>
    <name>K0I9E9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">sat</name>
        <name evidence="10" type="ordered locus">Ngar_c10290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10290"/>
    <dbReference type="EnsemblBacteria" id="AFU57971">
        <property type="protein sequence ID" value="AFU57971"/>
        <property type="gene ID" value="Ngar_c10290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.979"/>
    <dbReference type="HOGENOM" id="CLU_022950_1_1_2"/>
    <dbReference type="OMA" id="LQHMIIR"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="166"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="381" mass="42946" checksum="CDAB7AD2343B32E8" modified="2012-11-28" version="1">MLAGSIPLPHGGRLVNRFVASDKKTDGMFTVSVSDDLRNDIENIADGIFSPLEGFVGEQDFQSIVKAGRLKNGLAWTVPIVLDVDEQTAVKMKDAGQVALATGSDRFAILHVEETYAFDKLACAKAIYQTDDTKHPGVDKMIRMKDRLVGGKIDVVKRIEQSPLRKYRMTPAETRAEISRKGWKSVVGFQTRNVPHVAHEMLQKAALNLYDGLFVNPLIGKKKQGDFKDEVILAAYVALIDEYYPKDRTMFVTLHTEMRYAGPKEAIHHAIMRKNFGCSNFIVGRDHAGVSNYYHPFAAHEIFKNYMDLGIEPVFFPAFYYCKKCLSYANERNCPHGQEFREELSGTKMRNMVSSGEIPAEHLMRPEVAKTIISFNEPFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAM6</accession>
    <name>K0IAM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58381">
        <property type="protein sequence ID" value="AFU58381"/>
        <property type="gene ID" value="Ngar_c14450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14450"/>
    <dbReference type="HOGENOM" id="CLU_032903_4_6_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1443-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9907" checksum="539466DAB6F9A325" modified="2012-11-28" version="1">MIRCYKFRLYPTEQQVKIMNETMETCRHPYNESLGEKSTDWDIGFYAQKQLLTVRKQDNRYYNQVYSQVLQDVLLRLDKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBN7</accession>
    <name>K0IBN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56985">
        <property type="protein sequence ID" value="AFU56985"/>
        <property type="gene ID" value="Ngar_c00350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00350"/>
    <dbReference type="HOGENOM" id="CLU_2766229_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-35-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7778" checksum="F17C7E1979D7AF9A" modified="2012-11-28" version="1">MAAAGPDEHIIKCSYCGRDLIVKDNINNGVAFLSHLKNDHDIFYTPQRMTETKVNKRTDSGRQTFAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBU5</accession>
    <name>K0IBU5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c00750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57025">
        <property type="protein sequence ID" value="AFU57025"/>
        <property type="gene ID" value="Ngar_c00750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00750"/>
    <dbReference type="HOGENOM" id="CLU_032903_3_2_2"/>
    <dbReference type="OMA" id="GEHFECQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-75-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="163"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="279"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="373" mass="42498" checksum="11AF8A5C17872F7D" modified="2012-11-28" version="1">MLQALPVKLETSGDEKALLLATMKKYNEAANFLAEQAFRLKIANKVELQKRFYYQLREQFNLSAQFAVRVISKVVEAYKKDKRIKPVFRELGAIQYDQRNLSWKGLDRVSMITLKGRIKLRTRIGEYQKSRADRIRGQADLIYRKGEFYLIAVVDAPEQSEFDPVGAIGVDLGIENIATDSDGQVFRGETIEKARKRYNSLRARLQKKSTRSAKRHLKKMSGREKRFKRDINHVISKAIVSKAKGTIRAIALEDLSGIRSRATVIGRKQQRDRHSKWSFRQLRAFVEYKAKRDGVPVKFVDPKNTSRECPKCHNIDARNRRTRNHFKCTECGYEAMADHVAACNIAARAAVNQPIVAPLFSAVTSPLALAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBY3</accession>
    <name>K0IBY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57060">
        <property type="protein sequence ID" value="AFU57060"/>
        <property type="gene ID" value="Ngar_c01100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01100"/>
    <dbReference type="HOGENOM" id="CLU_2695890_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-110-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="2">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8643" checksum="E60C040F29120F5F" modified="2012-11-28" version="1">MKKHVGIDVDVTKFAYDSDNHEVDNPLHPTKILKPLRRASRRLSRKQKGSKNKEKAKTRLDFRYYMKELETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC43</accession>
    <name>K0IC43_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58921">
        <property type="protein sequence ID" value="AFU58921"/>
        <property type="gene ID" value="Ngar_c19890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19890"/>
    <dbReference type="HOGENOM" id="CLU_2505063_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1987-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9980" checksum="1EDE423A22A3BA11" modified="2012-11-28" version="1">MVGKDKRTWSLRLSSETISVIESIMLDVKMDMIKKQRGRWSVPEDEVFRAVMKEHLECIGKKDKERYQQLVKQIEETGGSGFFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICA4</accession>
    <name>K0ICA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58996">
        <property type="protein sequence ID" value="AFU58996"/>
        <property type="gene ID" value="Ngar_c20640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20640"/>
    <dbReference type="HOGENOM" id="CLU_2985805_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2062-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6711" checksum="09D8CD0F04B443D3" modified="2012-11-28" version="1">MVNCCKVSISNEKDCIKVYCKGWVEKQTWREINDIRRINGFAWLSNGKDSCWIKLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICC1</accession>
    <name>K0ICC1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57190">
        <property type="protein sequence ID" value="AFU57190"/>
        <property type="gene ID" value="Ngar_c02420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02420"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-242-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6642" checksum="2C586E428B0EC1DD" modified="2012-11-28" version="1">MAIRPYGTRPVLASKNRSPGYCIVCAAVATTEALFQLDGAVIIQRYCDKCLSDAKYVVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICI6</accession>
    <name>K0ICI6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c21610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="K0ICI6"/>
    <dbReference type="STRING" id="1237085.Ngar_c21610"/>
    <dbReference type="EnsemblBacteria" id="AFU59091">
        <property type="protein sequence ID" value="AFU59091"/>
        <property type="gene ID" value="Ngar_c21610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2140"/>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_2"/>
    <dbReference type="OMA" id="HHNASEH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2159-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="261" mass="28144" checksum="F2F748B9E832E490" modified="2012-11-28" version="1">MQKLALIKLGGSVVTFKDKPLAANTGAIDGISRVLAQLSTPAIIVHGGGSFGHYWSVKYDMHTKPAGYDPHGVSVVHESMIALNQIIINSMIRAGLNPYGMPPSVFAAGHKPVAAKIKQIYTMAKSEVMPVTFGDVVHMEGNKYSILSGDALMTMLAKVLRPSRVVFATNVDGIYKDMASRELMREIRVTTGRKKRSIEFSKASGADVTGGMQRKVAEAFKIASRGMDVLMVNGLMPERIAEAVVEGTRLQVGTVVKGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICK1</accession>
    <name>K0ICK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57335">
        <property type="protein sequence ID" value="AFU57335"/>
        <property type="gene ID" value="Ngar_c03870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03870"/>
    <dbReference type="HOGENOM" id="CLU_2353298_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-387-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="11318" checksum="CF9B3A4B82E77436" modified="2012-11-28" version="1">MYDTLYSWAFSIGMNIKKKDEELLRKLIFEIRAEETPGRFLEKLANQITDYRTNRNINLDVSMHGLLFEQNWFADKFYYMKSSVLGGLLGALSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICM5</accession>
    <name>K0ICM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exonuclease of the beta-lactamase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04330"/>
    <dbReference type="EnsemblBacteria" id="AFU57380">
        <property type="protein sequence ID" value="AFU57380"/>
        <property type="gene ID" value="Ngar_c04330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.416"/>
    <dbReference type="HOGENOM" id="CLU_050517_0_0_2"/>
    <dbReference type="OMA" id="FYIDPWR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-432-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="341" mass="38250" checksum="F16B8E23A3C589E2" modified="2012-11-28" version="1">MTGGVTLGQSGIMVRQNDITIALDPSHPVDCDFTFVSHAHVDHLHRRGRKKIKTQVLASKETTLIAHARGYEIVDAAEEQDGFQLVDTGHILGSRGLLVGDDDVYYTGDISVRERAFMKPAKVPHARTLIIESTFGRPEYVFPPLSEITHKTNKIISEMFNFGIPVILMGYTLGKAQLLTKLFGHWDPIIYDSVAKINSVYSELGVELAGGVTHKQAEEQKLLSKNRPWVMVAPLMSERNAFVREMKERYGAVTIGFSGWAIGSRYRYMMGLDYVMPLSDHCDYNELVEAVKQCRPDKVYTFHGFAREFAESLCEMGFDAEPVGNGHDRKAEKTLSLDSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICV0</accession>
    <name>K0ICV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59176">
        <property type="protein sequence ID" value="AFU59176"/>
        <property type="gene ID" value="Ngar_c22460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22460"/>
    <dbReference type="HOGENOM" id="CLU_163108_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2244-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="15017" checksum="E50AAE5EB7DEB909" modified="2012-11-28" version="1">MGDPKSSLQKQDRCTICGSRFAEKKCYYCESRICTSCMVPVEVSGSTTKCLTCDRNKVNRLSLVQMLKRNYYLFAIIVAFWLFTVFPIPFLHLAGIEVDPSAFQPVLIATGAMTIPFVFLFLAWQRKAPRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICX3</accession>
    <name>K0ICX3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59211">
        <property type="protein sequence ID" value="AFU59211"/>
        <property type="gene ID" value="Ngar_c22830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22830"/>
    <dbReference type="HOGENOM" id="CLU_2392988_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2281-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="9981" checksum="A522EC7BBC75139A" modified="2012-11-28" version="1">MSDTRLKPIHVIAMLAAVAVAVTAGELLYKAEAQEQQDNDNDSSETATKNVTWSVMARPAMDVMLSLLDIDGSVNITEQVANQILSSAQVSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICY0</accession>
    <name>K0ICY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59221">
        <property type="protein sequence ID" value="AFU59221"/>
        <property type="gene ID" value="Ngar_c22940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22940"/>
    <dbReference type="HOGENOM" id="CLU_2581537_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2292-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8559" checksum="97B113219F27C12F" modified="2012-11-28" version="1">MAKLAPTLIAVASAFTVQMALMNEAYGHPACTMPCGASSTTEPSLSWAMFVIAALATAFVVYGTTRQKAKNFAIFNIYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDI7</accession>
    <name>K0IDI7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF59 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25440"/>
    <dbReference type="EnsemblBacteria" id="AFU59466">
        <property type="protein sequence ID" value="AFU59466"/>
        <property type="gene ID" value="Ngar_c25440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25440"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2521"/>
    <dbReference type="HOGENOM" id="CLU_1323974_0_0_2"/>
    <dbReference type="OMA" id="FWKSCNG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2543-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="200" mass="22576" checksum="6DEB73E8AD5F1A09" modified="2012-11-28" version="1">MSQQQTVTEAQVYDALKKCMDPEIPVNVVDLGLIYGVKVASGKDVDIKMTMTTRGCPLHDTLVSDVKRYVSKINGIGNINVEIVWDPPWTLEKMNPDVREKLGFGKPRLRFQIDYEKSKPLKMGKFAKQEDGSLILANDKDQGFMVNEAIVEFWNTCDGTKTINQLTDQFSAKLGMPRQQVEQEVVQLVQQLLEAELLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDJ6</accession>
    <name>K0IDJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DUF72 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57735">
        <property type="protein sequence ID" value="AFU57735"/>
        <property type="gene ID" value="Ngar_c07930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07930"/>
    <dbReference type="HOGENOM" id="CLU_3039176_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-791-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6365" checksum="FB2D6ED640F7A63E" modified="2012-11-28" version="1">MITDSPDPKLQYLSNVVLTADHVSIRLHGRNKGYRYNYPYSKEELEPWADKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDL5</accession>
    <name>K0IDL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57775">
        <property type="protein sequence ID" value="AFU57775"/>
        <property type="gene ID" value="Ngar_c08330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08330"/>
    <dbReference type="HOGENOM" id="CLU_3130970_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-831-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5887" checksum="D36197135C643BF1" modified="2012-11-28" version="1">MLQKPLCAYSKPTVAYYEIYDDQVKFCPHREFAAVLKMLYHYFIILLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDP5</accession>
    <name>K0IDP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative two component transcriptional regulator, phoB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57830">
        <property type="protein sequence ID" value="AFU57830"/>
        <property type="gene ID" value="Ngar_c08880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08880"/>
    <dbReference type="HOGENOM" id="CLU_1902002_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-886-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="14714" checksum="C1FCCB995651C3ED" modified="2012-11-28" version="1">MTDGKGVPNIIVAEQDLHVSNLIMGTFKMEGFLPHQVMTSEDCLAKVKELGDKLDAIIIDGRLASDRGTMLIVNIRKMNSKAKIFVLAERFEEEHKTRVLDYGADEFTVKPLSIATLVSKISMLLLQGTPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDU4</accession>
    <name>K0IDU4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk</name>
        <name evidence="4" type="ordered locus">Ngar_c26340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26340"/>
    <dbReference type="EnsemblBacteria" id="AFU59556">
        <property type="protein sequence ID" value="AFU59556"/>
        <property type="gene ID" value="Ngar_c26340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26340"/>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_2"/>
    <dbReference type="OMA" id="MCLFLRI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="22325" checksum="AA213CC175F512A2" modified="2012-11-28" version="1">MATKGKIIVLEGTDKAGKTTQSRMLAEALKVLGKVCVIIDFPDYTTPIGTEIRAFLDGRRDYPAEVKHLLFSANRWEKKKEIESMVENGTIVVMNRYWQSNLIYGAANGMDTSWLLNLDKGLPEEDLVIIILVNPSISTKRAESQDAFESNPQLAAWAYKNYLKFAKQFGWKVIDGSKSKDQVHQEVMKIVRKELKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV2</accession>
    <name>K0IDV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59561">
        <property type="protein sequence ID" value="AFU59561"/>
        <property type="gene ID" value="Ngar_c26390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26390"/>
    <dbReference type="HOGENOM" id="CLU_027402_15_4_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2639-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="17166" checksum="E0F7BF3283123FE6" modified="2012-11-28" version="1">MSETRFNLIHEHERTGESVTNICRKYGVSRKTYYKWKKRYLARGIDGLKDLSRRPHNTKEQKVTPELEQTILGLRLESKFGTARIKFRLKRLGVSLSSRIVYKVLKRYGLNKLSCKLKRKYRRFSKRHPNDMVQMDIHTGSVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE17</accession>
    <name>K0IE17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57063">
        <property type="protein sequence ID" value="AFU57063"/>
        <property type="gene ID" value="Ngar_c01130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01130"/>
    <dbReference type="HOGENOM" id="CLU_1912407_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-113-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="132" mass="14899" checksum="3291A490B6842040" modified="2012-11-28" version="1">MPFFKLMQYVTYKASWESVPVLTTKEWYSPKFATDAAVIIRQGHIRACSCAMPVVTLATPITMEQLILEIGCGTICSTTARLGSMRQSGTTFWIPQVRSMIKDLTELNTKVAINRFINLQIYDLPDFLNGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEF1</accession>
    <name>K0IEF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59711">
        <property type="protein sequence ID" value="AFU59711"/>
        <property type="gene ID" value="Ngar_c27900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27900"/>
    <dbReference type="HOGENOM" id="CLU_2271128_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2790-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11355" checksum="47063C1F65213BEA" modified="2012-11-28" version="1">MPELIYNDNSELTAITVNESDQPLIIWYCKAFLQDGLTVVINYKDKSGRAHEIRTNNIQSDNAGFSLRMNNAQGRSKAAGARCTLQVSKGRIDLIGKVIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IER0</accession>
    <name>K0IER0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58245">
        <property type="protein sequence ID" value="AFU58245"/>
        <property type="gene ID" value="Ngar_c13070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13070"/>
    <dbReference type="HOGENOM" id="CLU_3075474_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1305-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5966" checksum="2C18F65FD6FA62E4" modified="2012-11-28" version="1">MKIIHMTSDKPSQKQTAPTSSEEDKPTLKDYKSEEEPSKRKMKPKEASDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEW7</accession>
    <name>K0IEW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59901">
        <property type="protein sequence ID" value="AFU59901"/>
        <property type="gene ID" value="Ngar_c29830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29830"/>
    <dbReference type="HOGENOM" id="CLU_2103586_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2983-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="12933" checksum="D0F8EAA014926F55" modified="2012-11-28" version="1">MFVVLTHEQLKSVVEGAPPLFGKDAARYRYDVVFLKEEPLTTKVAMKSVAVKDGIDRAYEGEGMLYFSRLMAKAAQSRLMKNIRTSYSPENDHAKLQYHYKAARSDGQEGGDGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF43</accession>
    <name>K0IF43_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisG</name>
        <name evidence="9" type="ordered locus">Ngar_c30650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30650"/>
    <dbReference type="EnsemblBacteria" id="AFU59981">
        <property type="protein sequence ID" value="AFU59981"/>
        <property type="gene ID" value="Ngar_c30650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3037"/>
    <dbReference type="HOGENOM" id="CLU_038115_1_1_2"/>
    <dbReference type="OMA" id="LDIHNTR"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="7">
        <location>
            <begin position="50"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="8">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="325" mass="36388" checksum="478E736781582D23" modified="2012-11-28" version="1">MPTVKFAVPKGSIEEVTFKLLEQAWQHVSGRGRTYRVKLGDPEIDVKILRPQEIPTYVQEGFYDVGITGRDWILEAKADVEVLLDLEIGRVKQVIAVPSSFPYKSLDEMIADFAKTGRTLRVSSEYLTTTSMHLKSNAAYKKAYGNADPMIITPWLRVGENKKVEIFLSFGATEAKPPEDVDAIFDITETGTTLAQNNLKIIDTVAESTAVLVANKKSLKDQTKREKIADMIALLRGVVDGRKKLHIFVNVKKENLPKLLKELPALKRPTVSPLSEDGWFGVNTVIDKNEFIRIVPKMRKLAQGLVVLEPKQILPLDEINLDGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF72</accession>
    <name>K0IF72_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58440">
        <property type="protein sequence ID" value="AFU58440"/>
        <property type="gene ID" value="Ngar_c15050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15050"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1468"/>
    <dbReference type="HOGENOM" id="CLU_147819_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1503-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9871" checksum="E9256611B52E7046" modified="2012-11-28" version="1">MQEVRRYDADIDYCPTCKGVWLDRGEIDKIATMQTRYDEEHYRRYHTDRDYDEYDDDYYNYRGHRRRRGFFGDLFDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF93</accession>
    <name>K0IF93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58470">
        <property type="protein sequence ID" value="AFU58470"/>
        <property type="gene ID" value="Ngar_c15360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15360"/>
    <dbReference type="HOGENOM" id="CLU_123710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1534-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="14843" checksum="C984BA73FD0AB4B1" modified="2012-11-28" version="1">MKTTNLRYVISVGLAVATLVVVPLFVGGLLVLPTSLAPLVGQAGLTAGALSAWFGPAFGIGAIALGTAAFVVSWKQRSFLVSGLLIVSGIIYMIPALIALANINIAVILIPGPILGFISGLVIVGLGVAKGIRTARMMTTMVTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFD1</accession>
    <name>K0IFD1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c15870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58520">
        <property type="protein sequence ID" value="AFU58520"/>
        <property type="gene ID" value="Ngar_c15870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15870"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="OMA" id="WEVMERD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1585-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15364" checksum="19C8DB0C57488751" modified="2012-11-28" version="1">MIDHDKSALEAAKTMAEKGISSVFVVKDGQPVGIVSERDFIKKICAKELPIAQVKIGDIMSKILTTADPETPIEVAVQRMVNHKIRRLPIMDGGKLVGIITVTDLAKHLRTTLLLEGALGDFSSSLDDAFAIEHEDNKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFE4</accession>
    <name>K0IFE4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60091">
        <property type="protein sequence ID" value="AFU60091"/>
        <property type="gene ID" value="Ngar_c31750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31750"/>
    <dbReference type="HOGENOM" id="CLU_2581541_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3175-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8546" checksum="E56C5BB75C351DCD" modified="2012-11-28" version="1">MPHKVYGISGEKAPAIHGEDESPLYFLGAADADADDDNKPYPSSERGCCDGEPESGASQGINAVQRRVNRSPTAIQRQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFF7</accession>
    <name>K0IFF7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NFACT-R_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31850"/>
    <dbReference type="EnsemblBacteria" id="AFU60101">
        <property type="protein sequence ID" value="AFU60101"/>
        <property type="gene ID" value="Ngar_c31850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31850"/>
    <dbReference type="HOGENOM" id="CLU_003612_2_1_2"/>
    <dbReference type="OMA" id="MVYGKRN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3185-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="1">
        <location>
            <begin position="440"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="661" mass="72846" checksum="F8EFE0B791AE5AB7" modified="2012-11-28" version="1">MELSGIELRYLVNEIGSRVTSGYYVSGVNAITKSSLLLKLHHPTQEDIMLVLSTRGVWITKLKFKPVEENSLEGAAQRELERAKLESIEQAGSERIVSMKFRHPDGKVRVAVCEFFGEGNLVICDEGMQIIAILNPIQVRHRTLNVGLRYAYPPARGVDVFEVTLDQMLSLRNEAKSLDVLRWIGRSISMPKKFVEEVAKRAGIEPYKQAARLSDEEVEKIYSIIKNLVNDVSAGRNHQPIIIMQEGDNKPVEALPIMTEEAAGKISTKKAAASYMEAVDEVLSAEILDIGRSSKTVELDRQIAILEHDLDEQNKAKEAVMQKSAAIRKLANELMALSYQNPDDGKVHDVLAANSASIVKEKGVKYIEVAGEQVEMQANLAKASSMLFARAKEMERGSASIEGARAKLLAQIEKLRSQTAAIHKKVVVKEQTAKEWYERYRWFITTDGLLAIGGRDASSNSALIRKHLTEDDIVFHAEVHGSPFFIVKNAAAPAKEGRIDPSLLQVAKATVSFSRAWKDGLSSADAYWVMPEQVKKGAPTGQFLPKGSFVIEGKRNYLKGVEIRLAIGIVQLNGRETLVCGPEEAIKSRAIFYAVLLQGGMDPMTAAKKAKSEFVKIAAAGDNSEEAAETIKRISLDDFVRALPTGQSRISFTARGQAGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFM2</accession>
    <name>K0IFM2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16770"/>
    <dbReference type="EnsemblBacteria" id="AFU58610">
        <property type="protein sequence ID" value="AFU58610"/>
        <property type="gene ID" value="Ngar_c16770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16770"/>
    <dbReference type="HOGENOM" id="CLU_720834_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1675-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="187"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="383" mass="43600" checksum="E464AC5B6569D5AF" modified="2012-11-28" version="1">MYFLLPKKKQASPHIPEHLEEIHLSLVDYHEAAAKSATLCGMHMDRSSAVGSNAHTVDRGLEHIGSNAWWLKEVRGARLFDRAVINLLRAAYLGTRVSLRVLLGRAKRDSLFIEKQINFKDFLFHSIRLFGLDNGKLLLLLEIPVHNHDKYRAYCPLNKEDFVVMTKHEDDILRQVFRPRSGDVVVDVGAHMGRYTLTAAKSTGRDGRVIAVEAHPYNYKMLCRNIELNGVSNVIALNCAAFSEEKSGLRLYLPDEQLGYTMHHSLMAGYLVSKYHEAAEKRYIEVQAHTLDYIVKTSGVGHDRINWLKIDVEGAEYEVLKGSSQILAASKDISLLIEVHGRETYRPVLELLRSHAFEIEFERTYDNGEKHILARKGGRPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFZ4</accession>
    <name>K0IFZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58705">
        <property type="protein sequence ID" value="AFU58705"/>
        <property type="gene ID" value="Ngar_c17720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17720"/>
    <dbReference type="HOGENOM" id="CLU_958524_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1770-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="33"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="290" mass="32776" checksum="FC89B8E3BEA80250" modified="2012-11-28" version="1">MKNLGFAAVGCAALLLIVALEATPNASKVPTCTCAAFRLDDIQDYFLNNVQVEVMSVFERRGLSLTVGVIGNHIGSDPMIVDYIKNRTGDPLFEIANHGWNHEDFTELSLEGQSSLVQKTNKKIFDLLAIKPTVFIAPYNTINNDTFAAVQENGMRYISANMTYDPPPYDIISSNQSLYRFPETVLIGDLSADDTHWITFSHQEVFEGIRESLDQHGFAVVTMHPQDFAARDMLNYQNMVDHNYIKELEMLLDKIQEQGIKVVTISEINRHVTQKQDIFFLQAPQPRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGB9</accession>
    <name>K0IGB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58845">
        <property type="protein sequence ID" value="AFU58845"/>
        <property type="gene ID" value="Ngar_c19130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19130"/>
    <dbReference type="HOGENOM" id="CLU_2191107_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1911-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12545" checksum="612F9B9E46A542A4" modified="2012-11-28" version="1">MNLARGLTESFTYLNLAEVLGMLEYVGLNHGYGKVLGQGLTEKFASLDEWKQSWILDALQRDNDFSRTFANRIQKNLTYLSLQMRERIKGLAAKFPYLERSPLEKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS2</accession>
    <name>K0IGS2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57022">
        <property type="protein sequence ID" value="AFU57022"/>
        <property type="gene ID" value="Ngar_c00720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00720"/>
    <dbReference type="HOGENOM" id="CLU_2550377_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-72-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="10185" checksum="8B3CEB6EFFD1092C" modified="2012-11-28" version="1">MIEEKISRNNREHMTTKRTYKFRLYPTKQQKILLDNTIETYRRLYNDSLGERRVDWDVGFYEQKQLLTLRKQDSKYLKQVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH20</accession>
    <name>K0IH20_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59155">
        <property type="protein sequence ID" value="AFU59155"/>
        <property type="gene ID" value="Ngar_c22250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22250"/>
    <dbReference type="HOGENOM" id="CLU_3057251_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2223-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5828" checksum="B1B201D8511333DB" modified="2012-11-28" version="1">MLPVLVYMSERPEDRSKDSKKTAEDNIEQPLDKQDPTEPVKVGGAKEGKGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH39</accession>
    <name>K0IH39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12030"/>
    <dbReference type="EnsemblBacteria" id="AFU58143">
        <property type="protein sequence ID" value="AFU58143"/>
        <property type="gene ID" value="Ngar_c12030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1148"/>
    <dbReference type="HOGENOM" id="CLU_082991_0_0_2"/>
    <dbReference type="OMA" id="LFEEPGK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1201-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="278" mass="30182" checksum="DA4FFD520363DBB9" modified="2012-11-28" version="1">MIDQIVKFFSLHDKNMAAKSTTSLDSVCTCQVCNHDFALDCLDCTCCTKDTHSMVLDDMSTPSRQVDIPAGSVTLEGDLYLGTKPGIVVFAHGSGSSRHSPRNQQVASVLQKAGLGTLLFDLLTKEEERIDERTAHLRFDIGLLADRLAAATDWLAKRASNSKIGYFGASTGAAAALVAAAKKQDMVSAVVSRGGRPDLAGQHLGKVRAPTLLIVGGNDHPVLDMNWEAFNKLKIKDKKFEIVPGATHLFEEPGKLEEVARLARGWFECYLHSEMTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH52</accession>
    <name>K0IH52_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58158">
        <property type="protein sequence ID" value="AFU58158"/>
        <property type="gene ID" value="Ngar_c12180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12180"/>
    <dbReference type="HOGENOM" id="CLU_1623511_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1216-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="17920" checksum="CA582A388E4FB3A9" modified="2012-11-28" version="1">MSTTDRNYTNVEQSGVNARTERVGDTTGEPPTNEAVDRDKASKLANLLEGLAFPATKEKILSHLNQRSPAMGNRINDVLEAARNNLDDGTEYDSAYDVEVAAGLVVERRTGSEKSYVRDRALNKANRRRIGESNRPDPYSGRESITPANSRDVSPNTPRGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH69</accession>
    <name>K0IH69_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59230">
        <property type="protein sequence ID" value="AFU59230"/>
        <property type="gene ID" value="Ngar_c23030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23030"/>
    <dbReference type="HOGENOM" id="CLU_2765843_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2301-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8348" checksum="CD4E5D54C4F4D382" modified="2012-11-28" version="1">MDKFIDRLMESAASAYAPRLEEMTRARKAELEEIRSKVKTSPDQVEAWFDKEIEKLQKMDVKEIMKNATAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH76</accession>
    <name>K0IH76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59245">
        <property type="protein sequence ID" value="AFU59245"/>
        <property type="gene ID" value="Ngar_c23190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23190"/>
    <dbReference type="HOGENOM" id="CLU_539276_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2317-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="551" mass="61645" checksum="BB5CBE77E01AA0C3" modified="2012-11-28" version="1">MSPLAVVDQAPLQVRALFARFNQVNDPAVSEFTGSIPEKFADAVNRVASQKIQTGDFVLRNRAVLKSFIKKFHSEAGTLTEHVRSSIELLDDPAARIVVSTHQPNLFAYGRVFKKIVLLETLKDAIEELDRGGSSRIVNLFLVVDHDFVDESWVRLAQLPSMQHSSGVMELRLPVSESKRWQMVCNMPVPSELVVHNWKRQVKSWIKSTAGADMRSVFIDNLEQFWQHVEASYERAKSHADLNSFLMSRVVNGAWNYSTLFVRLSEISSVFEDGFAFLISNSARYSDALRRAENMFMSCGIDTGVSPSSYLHAPVWVHCRCGSKASVKIVSKNGDLVLAGPCISCKKELELNLGRQNNLDLGGCNNIHDLSPRAIPIPLLLARDLGISCYASGTGGIGYLVDGSIVSGKLGIRLPLTLIWSSRDIYEGIGQRKAAAAMPSENNIELYLQLLEKQNAEYEKRMRPLLSMRAEKIRAGEPIDELLSQLFELKEGQRRIRQQISLAKKIRNIVSLSPCFIDYAVNFGMARTEQAWRNHLVKDGRLALPVVFQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH86</accession>
    <name>K0IH86_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c23340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23340"/>
    <dbReference type="EnsemblBacteria" id="AFU59260">
        <property type="protein sequence ID" value="AFU59260"/>
        <property type="gene ID" value="Ngar_c23340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23340"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2309"/>
    <dbReference type="HOGENOM" id="CLU_031740_0_0_2"/>
    <dbReference type="OMA" id="NWHTING"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2332-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="229"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="339" mass="38438" checksum="5917F8133DE0B7D3" modified="2012-11-28" version="1">MFNPKLLLISAIAVALVGSMLAFSSLYASTSDNGEKIVNGHGIGYYQTTGDVIDPTGSDGSASTGIDPMEYLRDFNYGRVSTTENGTVVREFTLVADDRQIAEISPGVYYNIWTFNGTVPGPTLRATEGDLIRINFINNGTKPHTIHTHGIHRAEMDGVFEIINPGGRFVYEFYAEQFGVYPYHCHVMPLEEHISHGLYGAYIVDPKTPRPEADEMIMIMNGYDTDFDTENNFYTVNGVPYYYMHHPIEIEKDRLVRVYLVNMLEFDQINNFHLHGNLYNLYRSGTSLTPDELTDMVTMSQGERAILEFSYKYPGQYMFHAHKTEFAEKGWTGMFLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA7</accession>
    <name>K0IHA7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA protection during starvation protein</fullName>
            <ecNumber evidence="1">1.16.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c23750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:48712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EC" id="1.16.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59300">
        <property type="protein sequence ID" value="AFU59300"/>
        <property type="gene ID" value="Ngar_c23750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23750"/>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2373-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01052">
        <property type="entry name" value="DPSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033921">
        <property type="entry name" value="DPSL_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="21391" checksum="7F2943E6DD942785" modified="2012-11-28" version="1">MPNIVALEVIRKNGVDVDKLIKLITAGVGAEFTTYYYYTILRMHCTGLEGEGIKEIVEDARIEDRNHFEAMVPRLYELGGALPRDIRKFADQAGCPDAYLPENWEDINSILKVLLAAEQCAIRSWGEVCDMTAGKDPRTYDIAQRIMQEEVEHEAWFIELLSKRPSGHFRRKFAGQSPHTGAQGSLIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB8</accession>
    <name>K0IHB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58288">
        <property type="protein sequence ID" value="AFU58288"/>
        <property type="gene ID" value="Ngar_c13500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13500"/>
    <dbReference type="HOGENOM" id="CLU_2204192_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1348-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="12262" checksum="7E060FEAD2EDB193" modified="2012-11-28" version="1">MSSYSAFLLNYTMYHTLHYTTTLITSLVLGIDMQLSMNEEANPNSSTKWNVRKVRSIHGQSVFFCRECQADVQVAEHVTGTTVEDDFTIYWDFVNGTCGHCVKDWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHD5</accession>
    <name>K0IHD5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase with radical SAM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c02240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02240"/>
    <dbReference type="EnsemblBacteria" id="AFU57172">
        <property type="protein sequence ID" value="AFU57172"/>
        <property type="gene ID" value="Ngar_c02240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02240"/>
    <dbReference type="HOGENOM" id="CLU_881677_0_0_2"/>
    <dbReference type="OMA" id="SGEWHEE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-224-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="35"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="321" mass="36628" checksum="064025A4BDCDDE5F" modified="2012-11-28" version="1">MVDLIYGRSITDLIREMPFYTSLIRKMIAYRLFGVKQPLHGSVDVNNICNLHCTHCYWWLNRKEEKDKTVEDWRKIIKDVFNKQRIFITTLVGGEPTLRPDIIELFCKEMPKRVCVVTNGTFPLKRYNGLYFYWVSLDGTEKVHDSIRGEGAYAKTKKNILDYTAGPPHNGIPAWKEIWLSMTINSRNYMTVEDLIEEWRGKVNKIGLQFHTPFAKGDPLMLPFGELRNSVVDKLIALKKKYPNYIVNPISQMSLMKGNWGGVGTTPVDCPSWAILSLDHMGRVKQPCCIGSADPKSMKPICEECGLGCYSILVAQGIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE5</accession>
    <name>K0IHE5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57192">
        <property type="protein sequence ID" value="AFU57192"/>
        <property type="gene ID" value="Ngar_c02440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02440"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-244-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9047" checksum="CA6E7F823B957FE6" modified="2012-11-28" version="1">MYNELMVSAFVLVNCHFPFDVKIADEVSKLPFVSNVYRTEGRYDLLIKLNADTEDKLKERISGDINTIHGIDATITLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ7</accession>
    <name>K0IHQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57362">
        <property type="protein sequence ID" value="AFU57362"/>
        <property type="gene ID" value="Ngar_c04150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04150"/>
    <dbReference type="HOGENOM" id="CLU_2327342_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-414-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11345" checksum="9E4F1B75DA54A6AB" modified="2012-11-28" version="1">MISGAKEELRQRQKGLSICYLKTEQNPLIGSFKSDLSLSLENAEQMMVWENVKQEKQYEKNQPTNNEEKGCLNHVYILYSYISNTIKSVGTRYFLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU2</accession>
    <name>K0IHU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thsA3</name>
        <name evidence="6" type="ordered locus">Ngar_c25880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25880"/>
    <dbReference type="EnsemblBacteria" id="AFU59510">
        <property type="protein sequence ID" value="AFU59510"/>
        <property type="gene ID" value="Ngar_c25880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2562"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="560" mass="60440" checksum="9B8C9C980713F120" modified="2012-11-28" version="1">MSSFQRGGDFSGQQQQQVPILVLKEGTTETKGKQAQRNNITAAKLIAELVKSALGPRGMDKMLVSPVGDVTITDDGATILKEVEIEHPAAKMMVEVAKSVDNEVGDGTTSAVVLAGALIDKAEELISKQVHPTVIVDGYQSAAEKAIEILREAAIDTGDDPASNKEWLYKVARTSMLSKLVSGESEQMAKLAVDAVVAAAEKLGGQYKLDADNIKVEKKAGGSLHDTRLVKGLVLDKEVVHGGMPKRIENAKIVLLNAPLEIEKTEMSAEIRISDPQQMQKFLEEEDRMLKSMVDKIKVAGANVVLCQKGIDDTAQHYLAKEGILAVRRVKESDVTKLARATGARIVTNIEDLTSDDLGNAELVEERKVETDKWVFIEGCKNPRSVSILVRGGSQRVVDEAERSVHDAIMAVKDVIEYPHVVAGGGAPEAFVSAKIRDWANSMSGRSQMAIQKFADAIETIPLVLAENAGMNPLDTQVELRSKISGKEIKYGIDVLGAKVADISRLNIYEPLAVKEQVINAATEAASMILRIDEVIAASKPKQSSSEPKSPQYGGGFDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV0</accession>
    <name>K0IHV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57462">
        <property type="protein sequence ID" value="AFU57462"/>
        <property type="gene ID" value="Ngar_c05190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05190"/>
    <dbReference type="HOGENOM" id="CLU_2875200_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-517-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7132" checksum="D079FD1D108247A1" modified="2012-11-28" version="1">MPSQMDNIIMAILNSLGTSGYPALQMCVFLLWSSKKEIISTLKNKMFFYTLGFACLEMVAEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0II70</accession>
    <name>K0II70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="1">2.4.1.217</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mngA2</name>
        <name evidence="1" type="ordered locus">Ngar_c27190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.217" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27190"/>
    <dbReference type="EnsemblBacteria" id="AFU59640">
        <property type="protein sequence ID" value="AFU59640"/>
        <property type="gene ID" value="Ngar_c27190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2698"/>
    <dbReference type="HOGENOM" id="CLU_028916_0_0_2"/>
    <dbReference type="OMA" id="MVRLHWR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050504">
        <property type="term" value="F:mannosyl-3-phosphoglycerate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012812">
        <property type="entry name" value="Osmo_MPG_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09488">
        <property type="entry name" value="Osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02460">
        <property type="entry name" value="osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="408" mass="45775" checksum="1D7EF9A468C74C0F" modified="2012-11-28" version="1">MLIIINNQNVFSNATTMKLDLPRYTERFGATSLHGVQRVYELDSGFDDGKSMSETLMKVGNEQISEIERKMAIVIPIKGERLRLLEGVLSGVPHDCLVIIVSNSPRQPVDRYMLEKDALQQFNKFVGRNALILHQRDPGLSEALNEVGYTSMLGPDGVVRSGKAEGMVLGMLLAKMAGKEYVGFIDADNYVPGAVNEYVKIFASGIAMSKTPYTMVRVSWIYKPKMSETGLYFSKWGRVSELTNQHLNSLISYYTGFETEVMRTGNSGEHCMSLKLAELLTFSSGYSIEPYEIVNVLEEFGGIIPTSYQDAMDKGVEVMQVETRNPHFHEDKGEDHLKEMVVASMGSIYHSKICPPKLREKILESLRTRNMLEEGQQEPPAPVKIDPFKDIDIRQFAKVLSKASTYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0II71</accession>
    <name>K0II71_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58653">
        <property type="protein sequence ID" value="AFU58653"/>
        <property type="gene ID" value="Ngar_c17200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17200"/>
    <dbReference type="HOGENOM" id="CLU_2284913_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1718-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12129" checksum="660772B61DF7DD15" modified="2012-11-28" version="1">MWAAILSVAVEHTHHSSHAQSHEEEEEHGGHGDAEPIVIKRVAAHQKLAQEMKKSGIDCDALPYGSHQLEHKEAYYSHGFALSSRLVTNKGLIKVNGKNIDFVQVLQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA0</accession>
    <name>K0IIA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c07800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57722">
        <property type="protein sequence ID" value="AFU57722"/>
        <property type="gene ID" value="Ngar_c07800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07800"/>
    <dbReference type="HOGENOM" id="CLU_2534790_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-778-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9356" checksum="4CA35F8D11E3F793" modified="2012-11-28" version="1">MPDDIIFSISNQPSMILIHFYPPKATKSRSNQRDTSMQLTLIEAIFAVTCYATMLTVTNLKRNNKNDDNNKHSKGSTLAINKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC6</accession>
    <name>K0IIC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isocitrate lyase /carboxyphosphonoenolpyruvate phosphonomutase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17900"/>
    <dbReference type="EnsemblBacteria" id="AFU58723">
        <property type="protein sequence ID" value="AFU58723"/>
        <property type="gene ID" value="Ngar_c17900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1768"/>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_2"/>
    <dbReference type="OMA" id="VKDLAPW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1788-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="290" mass="32233" checksum="23807E01AEA17816" modified="2012-11-28" version="1">MAKKARLLSLKEQLEDKNRIIILPGVFDALSARIAEQVGFDAMFQTGYGSSAALLGMPDFGFLNAGETVDNARRIIRAVSVPVLVDADTGYGNPLNVWRLVQDLESLGAAGIFLEDQIWPKRCGHMIGKDVIPKDEYLPKLKAAVEARKSKDFIIVARTDARAPISLDEAIERGKAYKKAGADVIFVEAPRSVEELKRVADEIDAPLVANMIEDGVTPTLPAQELLKLGYRIAVFPLSALYSATYAMREVLTELKKTGATKETRKMMVTFKDFNRFVDLDKYMNLEKRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID8</accession>
    <name>K0IID8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57797">
        <property type="protein sequence ID" value="AFU57797"/>
        <property type="gene ID" value="Ngar_c08550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08550"/>
    <dbReference type="HOGENOM" id="CLU_1297521_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-853-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="24067" checksum="0ABB6443FFC22263" modified="2012-11-28" version="1">MLSTEGRKISEHANEFVKNLKVGEHGCVFFTSREDFKGIQFTFVKSGLEQNWGVVYTTATETVNKVRDDMKQFGIDVQEHENEGSLVIVRGEDLYKDPENPDLKGWTAVAKSICDSFVAKGKKGVRVAADLSSYFLSKGLAKQWFQLEYALERKLAIPLTIVCGYDAQLIPASKDLDIIEYYKMVNREQREYVDAHSFAIYANKNKTIVFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP1</accession>
    <name>K0IIP1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57967">
        <property type="protein sequence ID" value="AFU57967"/>
        <property type="gene ID" value="Ngar_c10250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10250"/>
    <dbReference type="HOGENOM" id="CLU_2534791_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1023-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9514" checksum="4014C1A1E473B880" modified="2012-11-28" version="1">MIANKVLASDLREAIRGMDNLFGNSFIKLLLEHLQAHRILFDDDNNSCMYTFDEINSVLTPVFGEATPLLMSQLEKYLHVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV3</accession>
    <name>K0IIV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59900">
        <property type="protein sequence ID" value="AFU59900"/>
        <property type="gene ID" value="Ngar_c29820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29820"/>
    <dbReference type="HOGENOM" id="CLU_2534502_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2982-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9551" checksum="6FEFFBD5E7D4709F" modified="2012-11-28" version="1">MPRSTQIKAAELAGRLAALDVDEGIRIEKKNNDNAGDEKIFVNRNASGMFIVQHGSDFQYLESARQVVSVIKSRFGSKKYTIWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV9</accession>
    <name>K0IIV9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA protection during starvation protein</fullName>
            <ecNumber evidence="1">1.16.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c20920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:48712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EC" id="1.16.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59023">
        <property type="protein sequence ID" value="AFU59023"/>
        <property type="gene ID" value="Ngar_c20920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2072"/>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="OMA" id="HESWFLE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2090-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01052">
        <property type="entry name" value="DPSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033921">
        <property type="entry name" value="DPSL_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="4">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="20553" checksum="A47C45719CE7082C" modified="2012-11-28" version="1">MNVLKQNGANVDEILNGLIYNASVEFTAYYYFTNLRTHCTGLEGEGAKGVIEDARLEDLSHFESCIQRIHELGGSLPNDAIEFVRMSGCTFLQLPTPSTNLKEILKKCLIAEQGAIVNWNKMCNLTIGKDPATYDIAKDILKEEIEHESWFLELLYGRPSGHMRRKFPGERPHTQKHSRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM6</accession>
    <name>K0IJM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60250">
        <property type="protein sequence ID" value="AFU60250"/>
        <property type="gene ID" value="Ngar_c33350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33350"/>
    <dbReference type="HOGENOM" id="CLU_2748328_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3335-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7876" checksum="64D619DF65437484" modified="2012-11-28" version="1">MGGKINNEKGISKFFLPKGDGMLPGDIIWMYVKGAGRKLKYKEGYVIKEGAQGFQCKDCKYYLYILATVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN1</accession>
    <name>K0IJN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58487">
        <property type="protein sequence ID" value="AFU58487"/>
        <property type="gene ID" value="Ngar_c15530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15530"/>
    <dbReference type="HOGENOM" id="CLU_2893369_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1551-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="7092" checksum="A8C082EBAE669068" modified="2012-11-28" version="1">MADEQLRCNICGIAVNASQAKLHASTPSHESHRSELEHELEEVRKESYKNDRSVILQWESSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT0</accession>
    <name>K0IJT0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60340">
        <property type="protein sequence ID" value="AFU60340"/>
        <property type="gene ID" value="Ngar_c34250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34250"/>
    <dbReference type="HOGENOM" id="CLU_159725_1_2_2"/>
    <dbReference type="OMA" id="NISHTRI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3426-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10496" checksum="BAE45ADBA4BEEFDD" modified="2012-11-28" version="1">MAAGYRTHVSIIADILSTAKQYSYEGYDSGATVTHLIRKANVPYQRLSSIVSTLTQSGLLYENSAKYKISEKGIEFLKAYSEFKEFAESFGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJU0</accession>
    <name>K0IJU0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16040"/>
    <dbReference type="EnsemblBacteria" id="AFU58537">
        <property type="protein sequence ID" value="AFU58537"/>
        <property type="gene ID" value="Ngar_c16040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1572"/>
    <dbReference type="HOGENOM" id="CLU_331686_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1602-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="436"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="863" mass="96772" checksum="A98D0DFD974864B7" modified="2012-11-28" version="1">MQGGEKHQGFIFSLLNPPVPLGGNIIALDIYVDELPIPKKSVFVATQDDVVNAAALSESQPVPFKPFESARFLVIKEGGLDEKKKHKIVIMSKMEGFEQIMIPFTFTDYPGYRSGRIFVPETAQAQEPLVLSEDGMVFKNFTAPLTLSGKKAYIVCSSNGAISANWTWMGVRYDNGGLYVPPVRAFGRIIVEISMDDGVRKRLPHFVVESRHENGILYTRHELAGLEVKRKLLVPFDSRGFIMTLELRPLSGFRALLRRKTAKKRKIRVHFLIDGNITSYGLAAVSQNVVSKFRAKDNCLQLGTVARDIGAQYSGVIGIAPKRLKPSRILTDSYDNDLEMSYDIEVEAGKTIALALVGTGSFTGPESCIKEFRHMRDNYSQLVEDTEKGFAEYSSSTLSARPPPARQNLGLARLLAAYDKAKACLRYLKAEYDGLGEGICAGLPRFPNYWARDTGWTLRGYLAIGDYRFAAATIDNFLRHQAKTTTKAATKGELPMIISGKAFLHTTTYGSADSTFLFPWAIREYVLGTGDIGYLKKRWDSIVDLVNYGFLKDVDGDGLIEHGFTGTAEKLPIQDSTWMDHIDRRKSANDIQALFYESLRIGSELAAMAGDSENEARWSSKAKELQETIDREYWNTSAGFYYDTIRKDGSKDPSIRPNALVLLLSDVVRERSRADSVLSRIEEQDMTTAWGVRTLSSKDQKYQPTLYHDGAVWPLVTGWAAASEIKFGRHEQALRYMGSMAERILHENGMFAETYRGDRPEPFNSCILQAWSVGMYAYALREMMLGMKINMIDNTIQLEPNIPESLKETAVPLDFEHFIPSKDGIARLYVKIDPRNEKIFATFRNSGSKRPEIFSDSYSLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJV4</accession>
    <name>K0IJV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small heat-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c25811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25811"/>
    <dbReference type="EnsemblBacteria" id="AFU59503">
        <property type="protein sequence ID" value="AFU59503"/>
        <property type="gene ID" value="Ngar_c25811"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25811"/>
    <dbReference type="HOGENOM" id="CLU_3021094_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2581-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6491" checksum="024A3DB235921987" modified="2012-11-28" version="1">MKYRQQRLPRGKYHRVIDLPSDTDIETAKSKYTNGILEITFNKKAKPKGREIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK01</accession>
    <name>K0IK01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60450">
        <property type="protein sequence ID" value="AFU60450"/>
        <property type="gene ID" value="Ngar_c35370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35370"/>
    <dbReference type="HOGENOM" id="CLU_2313656_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3538-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="10649" checksum="2A99C64199C2C39A" modified="2012-11-28" version="1">MSEIDSTKKVHLIVHGQRQLLEPVKDKLAGRFKRENMQPASLDKAGEAGEYVAMLWPPMAAKEIVVSQITGTGGSGSGGGGRGMGAWGSVSQKELFRVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKB6</accession>
    <name>K0IKB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58797">
        <property type="protein sequence ID" value="AFU58797"/>
        <property type="gene ID" value="Ngar_c18650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18650"/>
    <dbReference type="HOGENOM" id="CLU_2875206_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1863-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7132" checksum="7B010431D1D3F7BE" modified="2012-11-28" version="1">MGVEYLPEAMKAAGLLRRLNVEYVAEVSPPEYNSKRDEETLLLNPKAIRRYSKQLANVVANVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH2</accession>
    <name>K0IKH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59763">
        <property type="protein sequence ID" value="AFU59763"/>
        <property type="gene ID" value="Ngar_c28430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28430"/>
    <dbReference type="HOGENOM" id="CLU_2695897_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2843-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="7881" checksum="0BD4285FD433AAFC" modified="2012-11-28" version="1">MLGEIIGELKGKVTGQRVASSEVRIETSVQETGKLLGVEVNQTVTFWVEARKNGLPYGEGLGNIMTRDGEMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKN7</accession>
    <name>K0IKN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21370"/>
    <dbReference type="EnsemblBacteria" id="AFU59067">
        <property type="protein sequence ID" value="AFU59067"/>
        <property type="gene ID" value="Ngar_c21370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21370"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2121"/>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="OMA" id="WAIMRYL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2135-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3" evidence="1">
        <location>
            <begin position="199"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="510" mass="57438" checksum="4CC9E5B730D144C5" modified="2012-11-28" version="1">MTNYRGNFLYGFIACGPYELVPEFVFDKLFCPSVETDPNTGEVKVAQCGLRRIEGALLKEYKRDEVFLAHPEMLDKCVGPDTKVVGINVMDPLGMAPVTTTMSPEKLSYVAMKFKKMCASIIQLKKKHNFKVVVGGNGSWELAKPDRMKIHGIDTVVIGEADELALDLFHDLEAGDAPELLHTFVRNIENVPMMQGPTVNSLIEAMRGCGRGCDFCDVNKRSKKDFPLERLQKEAKLNLDYGFDSIWLQSDEMLLYGCDNKDFVPNADAILHLWSGLKSTGARFVGTTHMTLSAVASSPDLIKKMSEINEMHVAGGRWLATNLGVETVAPRMVKKHLGVKTKPFQPEEWGAVVREGCKILNQNNWFPALTLIIGWPDETPDETQYTIDLIDDFKQTNMRGLVAPLLYQDFSEKNSMHFGNLNEAQFTLFWRCWEHNLRVINDIIPIIIRNKTYGPAMKVFMAALIKAGTWAIMRYLRGLSKELFNGQVPEDIVERYSRKKSVTAAASPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS9</accession>
    <name>K0IKS9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2, subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">eif2b</name>
        <name evidence="5" type="ordered locus">Ngar_c30420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30420"/>
    <dbReference type="EnsemblBacteria" id="AFU59958">
        <property type="protein sequence ID" value="AFU59958"/>
        <property type="gene ID" value="Ngar_c30420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30420"/>
    <dbReference type="HOGENOM" id="CLU_026663_3_1_2"/>
    <dbReference type="OMA" id="FIRYYVV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="4">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16089" checksum="7597EFF74A6FABE4" modified="2012-11-28" version="1">MTKAQSAEYESLLKRLQDKLGGTAKKARSRLEIPTPQIIWVGKNTIFRNFMDFPKALRRDPEKLLLYLNKELASAGYIAGERVIFLGRKTPSSFGALIDRYIKDYVQCPVCGSPDTHTEKSKPKVAFLICEACGAKSSIKGNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT6</accession>
    <name>K0IKT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S25e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps25e</name>
        <name evidence="5" type="ordered locus">Ngar_c22270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22270"/>
    <dbReference type="EnsemblBacteria" id="AFU59157">
        <property type="protein sequence ID" value="AFU59157"/>
        <property type="gene ID" value="Ngar_c22270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22270"/>
    <dbReference type="HOGENOM" id="CLU_143930_0_0_2"/>
    <dbReference type="OMA" id="KVITIQH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_S25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="11548" checksum="674148142518AF27" modified="2012-11-28" version="1">MGGNKKKPVGSSDKTAQVGPGGAEIKQASEEKKKAPKPQQKQKLAVMVEEPAGMKALQGMKSITTQALARNIGVKISVANTFIKSLEQKGTIRAVGGYSGHKVYQLVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKW4</accession>
    <name>K0IKW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59182">
        <property type="protein sequence ID" value="AFU59182"/>
        <property type="gene ID" value="Ngar_c22520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22520"/>
    <dbReference type="HOGENOM" id="CLU_2712970_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2250-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="7834" checksum="DB02830F41321CF8" modified="2012-11-28" version="1">MGISPEKCSDIEILKHRCLDGPNSPCSMGRPPLPPKLAPFILSILTGYGIALVTGVYAVRKIRKVRKKATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL51</accession>
    <name>K0IL51_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59327">
        <property type="protein sequence ID" value="AFU59327"/>
        <property type="gene ID" value="Ngar_c24020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24020"/>
    <dbReference type="HOGENOM" id="CLU_2366306_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2400-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10437" checksum="A157EBDD950E26F3" modified="2012-11-28" version="1">MLLTVGSGYLARAGMHYSDAAQDDVIISQEFAACGSCLDNNQKIMDAYVESLRGKMQESLQDMILNAGIGVALFCMGAGFSMIYIKWYRNTEPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC9</accession>
    <name>K0ILC9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC efflux transporter, FtsX-domain permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c25090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25090"/>
    <dbReference type="EnsemblBacteria" id="AFU59432">
        <property type="protein sequence ID" value="AFU59432"/>
        <property type="gene ID" value="Ngar_c25090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25090"/>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OMA" id="FYRHQTQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2508-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="313"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="414" mass="43882" checksum="99D4AD9BF82558FE" modified="2012-11-28" version="1">MNIFQIFSLSFDALKERKVRSALTVLMVVVGSALMTALNGLGAGFGAFIDDQFSQLAPNILFVTSAQQSSQGPIGGGPPPAPKITLNEAVVSRIRSLPFVDDVIQSYQGQITLQSRGKSVDTTVFSIDPQKLYVIAPTIKFVEGSSIRQNDPSAIILSDRVANPPGDDVPFATIGQSLRVTYTFVDPDTGKQEEESKSFVVSGIMKPTGNPTIDNAVVFNRVSGDALLNKAGKYDALLVAAEDGDHVAIVEEEIRKLYGNDIGITTPEAILETIQQFTSGFTSFILSIALVALLVGGVGIITTLYTSVMERIREIGTMKAIGAQNGFILSLFLAEAMTIGIFGATLGMALGIVGGYVLVASFAQGPDASGLTPVFLPTDLAYVWALSVGLSILAGSYPAWKASRLPPIVALRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ7</accession>
    <name>K0ILJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57119">
        <property type="protein sequence ID" value="AFU57119"/>
        <property type="gene ID" value="Ngar_c01700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01700"/>
    <dbReference type="HOGENOM" id="CLU_040681_9_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-170-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="16429" checksum="CF4D88A43886C6C0" modified="2012-11-28" version="1">MMDEAKNMKASDVMSVDIIAATENISAIEVATRIVLGAINGMPVISKDDGKLLGIVTTIDLLRAIRSSQDLTTIIAKDIMSPNPLSVKQDTDVNEIIDVMDRNGVMMVPVVENDGRLIGICSRSDILKEILNERFVTIGRTRTVTTTIGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW8</accession>
    <name>K0ILW8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aIF-2</name>
        <name evidence="5" type="ordered locus">Ngar_c28270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28270"/>
    <dbReference type="EnsemblBacteria" id="AFU59747">
        <property type="protein sequence ID" value="AFU59747"/>
        <property type="gene ID" value="Ngar_c28270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28270"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2792"/>
    <dbReference type="HOGENOM" id="CLU_002656_3_3_2"/>
    <dbReference type="OMA" id="FRQSKPA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="543" mass="60323" checksum="1634E32D9800FD9D" modified="2012-11-28" version="1">MTGPLYAKLAKAETPIPGLLVIDTPGHEVFANLRARGGSAADIAIVVVDVNKGFEAQTIESIDILKKRKVPFVVALNKVDMVTGWRASGRFISEEVKKQDPSVQMLLDEKAYAVVGTLSRLGFLSEVFWRVRDFTKEVAIVPISARTGVGIPELLAVLVGLTQQYMAKKLERHEGPAKGIVLESSEEVGLGPSANIILLDGTLRHGDIVVVGKRDGAVATKTKALLLPKPLDEMRDPRDKFKPVTEVVAAAGLKITSPDLEGVLAGSPLYVYDQKKGKEELEHLKSLVESEIKTAIVSNTETTGVILKCDTIGSLEAITDLLRKENVPIRMADIGNITRRDIVEASAVKENDRYLGVVLGFSVRVLDDAQKEAQDREVKIFNEQIIYNLVRSYTDWVAYQREHEELILFNELPPICKFQFMKGFIFRRNDPAVFGAEIQIGRLRQKVQVINEEGKKVGTVHQIQESGKAIEEATTGMQVAVSIKEPTIGRQINEGDIFYTDINSRQAKQLLERFNHRLNEKEKEVLDMLVAMKRKNDPTFGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM12</accession>
    <name>K0IM12_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">argS</name>
        <name evidence="12" type="ordered locus">Ngar_c05560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05560"/>
    <dbReference type="EnsemblBacteria" id="AFU57499">
        <property type="protein sequence ID" value="AFU57499"/>
        <property type="gene ID" value="Ngar_c05560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.531"/>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_2"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="517"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU57499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="634" mass="71414" checksum="CDB5E24E08C5D060" modified="2012-11-28" version="1">MTFRLFRNDVRRLVKQALDNAGYPAVEFDVSEPPQKEFGDLSCNVAFLLARHAKKPPQKIAAELVEAIRLNIKDTCVLSAETAGGHINFKADYSRLSPATLGQVLKSPENYGYPDSGQGRHIVIEHTSVNPNKALHVGHMRNVIIGDTLYRIMKATNHRTTVLNYVDDSGLQVADIVVGFKFSGFNVEPPKGKKFDHYCGDEVYVKINEMYEKDPLLAEKRKLVLKEIEEGKSEIARFATDITLRVLNEQLKTCWRMKARYDLLNFESHIVVSKLWSKTFELLKKERLTHFEEEGKNKGCWVIEAKDEEDKVLVRSDGTATYIAKDIPYAAWKLGLIEDPFSYREYLGQWDGSMLYATTLGGSDKPTAAKKFNGGERVITIIDSRQARLQRIISQVLSKIGAGTQEYFHLSYEAVTLSSETAKAFGIDIGDRQFMHMSGRKGIYVNADYVLDTLHTKAYEEVKTRNPGFTEEQLNAIAEEIAISAIRYNMIKQDLDKIITFDVKESLSLEGDTGPYLQYAYARSQRILEKSGQDIAGSNFAFDRLAHESEIALIKEIAKLDLVVEDAAKSLSPKSLARYAYNLATTFNLFYEKVPVLKEQDADIRMARLALVKAFGVALKNALDVLGITALDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM58</accession>
    <name>K0IM58_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60022">
        <property type="protein sequence ID" value="AFU60022"/>
        <property type="gene ID" value="Ngar_c31060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31060"/>
    <dbReference type="HOGENOM" id="CLU_2165180_0_0_2"/>
    <dbReference type="OMA" id="WIEEDYC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3106-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12519" checksum="BEC3702FE4C5068F" modified="2012-11-28" version="1">MLLSYFVMALYLVRAKPRKDLMKSLRQELDSGSISRLKPFGEELHHGLDNARADGSYAYWVEEDYCSPPLAMERASMLDRYFDEITVDPVGSEDEGWNKIKDKPSIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM60</accession>
    <name>K0IM60_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60027">
        <property type="protein sequence ID" value="AFU60027"/>
        <property type="gene ID" value="Ngar_c31110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31110"/>
    <dbReference type="HOGENOM" id="CLU_2930317_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3111-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6836" checksum="7FD65D3665ADE093" modified="2012-11-28" version="1">MCQAPFLFENNLEDHKKVHMPREPEPAPAIISSSSSNSISAGKKQRKSTKEARRKQQKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM96</accession>
    <name>K0IM96_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfcS</name>
        <name evidence="7" type="ordered locus">Ngar_c07260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07260"/>
    <dbReference type="EnsemblBacteria" id="AFU57669">
        <property type="protein sequence ID" value="AFU57669"/>
        <property type="gene ID" value="Ngar_c07260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.702"/>
    <dbReference type="HOGENOM" id="CLU_042324_2_1_2"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="328" mass="36587" checksum="CCFAB1C415552E24" modified="2012-11-28" version="1">MSAKETDLANLMWSEKYRPKKLAEVVNQKEIIKGISNMIKSPDIPHMLFSGPAGVGKTTTALCIAMELLGEEWKKNTLELNASDERGIKMVRERVKEFAASIKLAGDKEFGTPKIIILDEADEMTSEAQTALRRIIEDSARTTRFIIICNYLSQIIEPIQSRCVVFRFTRLPREDVIDYLKMICEKEKVKFEEKALAQIYDATGGDMRHSINIMQAAAGMGSVSSANVIAAMGLSGRARVNEVLKLALSGKFNEARAKLLELTQVYGMSETDFMKYANQEAYEMKIEKPDEFAAIMAEYDYRLAAGAHPDIQLSALLAQLGKLGAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB4</accession>
    <name>K0IMB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60157">
        <property type="protein sequence ID" value="AFU60157"/>
        <property type="gene ID" value="Ngar_c32410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32410"/>
    <dbReference type="HOGENOM" id="CLU_3163253_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3241-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="47" mass="5149" checksum="AF651C8B6946274C" modified="2012-11-28" version="1">MLPVLQAAAKEVGRKPIFTDGAQWYIMTHAGGSVYVIVIIIMSMVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG7</accession>
    <name>K0IMG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57884">
        <property type="protein sequence ID" value="AFU57884"/>
        <property type="gene ID" value="Ngar_c09420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09420"/>
    <dbReference type="HOGENOM" id="CLU_3113192_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-940-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5797" checksum="1F960B7185A1F3FC" modified="2012-11-28" version="1">MVHWPSYNESLVRRGEVMLDFDVIDGWQEELMNEGKVGEPSTIPTHLYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH7</accession>
    <name>K0IMH7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS66 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57904">
        <property type="protein sequence ID" value="AFU57904"/>
        <property type="gene ID" value="Ngar_c09620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09620"/>
    <dbReference type="HOGENOM" id="CLU_2857208_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-960-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7249" checksum="76E7C961EB9AEFFD" modified="2012-11-28" version="1">MSLKLLGLSYEKISGHFQLLFNLQVTDAAINHAVMKVAEAFDPRYNELVDDLLKEKNVRGDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM2</accession>
    <name>K0IMM2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="9" type="ordered locus">Ngar_c34940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34940"/>
    <dbReference type="EnsemblBacteria" id="AFU60407">
        <property type="protein sequence ID" value="AFU60407"/>
        <property type="gene ID" value="Ngar_c34940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3496"/>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="OMA" id="FNNHAHV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="188"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="219"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="308"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="377" mass="42723" checksum="491D682448E918F8" modified="2012-11-28" version="1">MMAFQRKAILITYPVDQAIKEAISLADAAGYEIVDTVTQRQITRSRFGIGRGKAEEVKELVEELRPDVIIFDEVIKPTQMYNLASLCKVEIVDRERLILEIFERRASTTESQIQIKLAQLRYDMARAREKVRLARAGEQPGFYGLGKYEADIYFLDIRKRAAVLKKKLEKEETRRQLHRNQRTRAGLPTVSLAGYTSAGKTTLFNKLTGEAKATDKQIFITLSTFTRAIDLHGDKVLLNDTVGFISKLPAYMIDAFKSTLDELTYASLVLLVIDISEPIEEVARKYDSSLDVINEFKVPATKIIHVLNKVDLTTIEDAFDKAGQLGILDTKRVIPVSAKTGYNINQLKNLIRTVLFEMEKGEDAEVKEERVEKEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN4</accession>
    <name>K0IMN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PhoU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11070"/>
    <dbReference type="EnsemblBacteria" id="AFU58049">
        <property type="protein sequence ID" value="AFU58049"/>
        <property type="gene ID" value="Ngar_c11070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11070"/>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="DHAAKIS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1105-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="140"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="334" mass="37471" checksum="D32DC3D385A9AB53" modified="2012-11-28" version="1">MPRYARRLQKIGSSILISLPSQWVKSNNLKKGSIVPVDINRDNSISIFPSEDMADEAKEVTIPYSPASMDTLVSQVYGAYLLGYDMIRIKANSQISFEDTDRVKKAMRKLVGLEIVDEDGFHISAQFLLDANTLDAEKILRRMSAIVAGMYRDLLEAIRSKENSIRRVISGRDDEVDRQYFLLVRLIRSAMMDQKLAGKLNLSNIDILDYRIAANLLESAGDYIVDLADTIQDFSKIRIVDEIAEAGALVERMQEKSVAAFVSKNRAESNVVVKTYDKFNEILNSIKNSTESKNPESAIAVLNLTYSMDKIARCWVDVADLVKPVHLTAPLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV4</accession>
    <name>K0IMV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hemerythrin HHE cation binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13410"/>
    <dbReference type="EnsemblBacteria" id="AFU58279">
        <property type="protein sequence ID" value="AFU58279"/>
        <property type="gene ID" value="Ngar_c13410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13410"/>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_2"/>
    <dbReference type="OMA" id="VRVKYVT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1339-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="181" mass="20363" checksum="C79100440A61DC76" modified="2012-11-28" version="1">MSTESLRKDHHLIEKMLKALDTTAALLKSGKTIPAPILDQMIDFTKNFTLVCHHGKEEDSLFPALEKSGMPREGGPIARMLFEHEVTKQLASKLEESAKIYLQSGRADSLVADIKGYIDHVALHLAKENHRLFMMADMILQGKADQINRDLARSEEEKLKELGKTRSHYEKLVSDIELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV8</accession>
    <name>K0IMV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58299">
        <property type="protein sequence ID" value="AFU58299"/>
        <property type="gene ID" value="Ngar_c13610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13610"/>
    <dbReference type="HOGENOM" id="CLU_1163828_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1359-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="238" mass="27253" checksum="84B6C6FCB8E83E16" modified="2012-11-28" version="1">MARYIYGLDPASKNDWFGIVVHELMMAAHERPPRLRAINQMTHTSFDKIYGYLVEDMFKRYPPYYIVIDYSNEKTFSDLLVRLYGKEKVERIAFSNANKLMLKEDGLAIMKQEYKFPNPAKVADPAVAQLILLLVQQLKSEQILQTATGKTTFDHPRGQHNDLAIAWELSIHGCLKFMIRGQRNTGLVYSRKYDYDDYASSSLGYASNNNYNNHGLGSGVPDRVGVTRTDRAIIYPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN02</accession>
    <name>K0IN02_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c15860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58519">
        <property type="protein sequence ID" value="AFU58519"/>
        <property type="gene ID" value="Ngar_c15860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15860"/>
    <dbReference type="HOGENOM" id="CLU_2433960_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1584-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10355" checksum="C2CAC9870CBF479F" modified="2012-11-28" version="1">MKTKVLYYTAAAATAIAGILHLMLAPNMLNFNPNGTTLFFVGGAAQVFFWALSMVRRWVWVWDWNWRHGGSDGDLGNYEVSRQSDNWQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN09</accession>
    <name>K0IN09_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="2">ADH synthase</shortName>
            <shortName evidence="2">ADHS</shortName>
            <shortName evidence="2">ADTH synthase</shortName>
            <ecNumber evidence="2">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroGFH</name>
        <name evidence="2" type="synonym">aroA'</name>
        <name evidence="3" type="ordered locus">Ngar_c16210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16210"/>
    <dbReference type="EnsemblBacteria" id="AFU58554">
        <property type="protein sequence ID" value="AFU58554"/>
        <property type="gene ID" value="Ngar_c16210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1590"/>
    <dbReference type="HOGENOM" id="CLU_057069_2_0_2"/>
    <dbReference type="OMA" id="CEYWGMP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01949">
        <property type="entry name" value="AroFGH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="27855" checksum="37FDAC06F8520D57" modified="2012-11-28" version="1">MVFGRDIRLSRILKDGKMLCIPMDHGISNGPIKGLEDINGMIYQCASAGLTCVLVNKGIIKTMPRPPDIGLIAHFSGSTSLGPAPNRKMLMGSVEEAIRLGADAVSLHINIGAKEEPEMLQKLGMVADKCTEWSVPLVAMMYPRGENIKNPHDPEIVAHAARVGAEAGADIVKAVYTGDIDSFKRVVKSCPVPIVIAGGPKANTDREILEMCAGAMAAGAKGVTFGRNIFQHKNPPAMVRALRKVIIDNKPVKEALKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN63</accession>
    <name>K0IN63_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ion transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c18920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18920"/>
    <dbReference type="EnsemblBacteria" id="AFU58824">
        <property type="protein sequence ID" value="AFU58824"/>
        <property type="gene ID" value="Ngar_c18920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18920"/>
    <dbReference type="HOGENOM" id="CLU_055047_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1890-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="6">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="308" mass="34706" checksum="9AF1FF1FD3DC8DA4" modified="2012-11-28" version="1">MEEKPSLPRSKLPSERADDTVVNILRGIVGSRAFDFTITSVILLQAVALALEATPALYSNNNGERTNDAARLFGTVHTAVVMVFIVEAGMRLGALCPKPQDYFKDGWNSFDFAVIVLSLIPVTGPFATIARLIRLLRVTRLVTKSKELRAIVSTLVRSIPSIFNILILLGMLFFIYAIIGYHLFSNVDPQRWSSFLASLTTLFQVITLEGWIDITEPIVSQLGPLYWLYFATFIVIGTFIIINLFISVIVRKSEEAYKQLQLESGTPLTQQEIAEELREIHRILEELERRISRQDDDSKNGSDRIDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN70</accession>
    <name>K0IN70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19270"/>
    <dbReference type="EnsemblBacteria" id="AFU58859">
        <property type="protein sequence ID" value="AFU58859"/>
        <property type="gene ID" value="Ngar_c19270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19270"/>
    <dbReference type="HOGENOM" id="CLU_034585_2_1_2"/>
    <dbReference type="OMA" id="PGHIHTL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1925-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="71"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="22996" checksum="13360F4690C01B90" modified="2012-11-28" version="1">MDPVDKAILAALYASTLDPSISAYDRLKARLPLSQEFYNSRVSHLAKMGLVEKSDPSKLTFIGRDALKVVLVGGVFDLIHPGHIHTLKAAKAEGDVLVVVVARQSTAQKIKKDRKIYHDESQRKELVSSLNFVDLVLIGREGTLYDTVEYVKPNVIALGYDQAHSEKDVAENCKKRNLNVHVIRLSTPIPGSKSSKMKEELGDSIYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA7</accession>
    <name>K0INA7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59044">
        <property type="protein sequence ID" value="AFU59044"/>
        <property type="gene ID" value="Ngar_c21130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21130"/>
    <dbReference type="HOGENOM" id="CLU_1551748_0_0_2"/>
    <dbReference type="OMA" id="HTDQDML"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2111-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="18332" checksum="F1F08B95C6C07D0C" modified="2012-11-28" version="1">MFGKSGSKWKAEYDDTLYKIYDWDGNLAGYLFPQYGDIEPKEQEDEIIDELNKTHSEVPEATLLLPMVKLDLLDKQEGLDIDYVILSLEANAERTIVWKKWLHDNAKSFKIVGAAVYTAREDRNMLSIALGIVTTIRLGEKEVRDFLSPLLDKLHEDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH6</accession>
    <name>K0INH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24650"/>
    <dbReference type="EnsemblBacteria" id="AFU59389">
        <property type="protein sequence ID" value="AFU59389"/>
        <property type="gene ID" value="Ngar_c24650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2440"/>
    <dbReference type="HOGENOM" id="CLU_955169_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2463-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="291" mass="33698" checksum="52A034EC380D6318" modified="2012-11-28" version="1">MTFYETASGKINVIETLSKEPKNDTVLCIHGLCCDARIFTYIGIKLSEAGYNVASMDLPGHGRSDGEKGDLDFDMCIKSIDQIVRDLKKRSSRVFLLAHSMGSTFALWYAHLFKSSIDGLILLCPYIRVRNMKRRFDAEPNTIQSLLLLLGRIFVPSKRLDITKAFPTYVRIGGDRVAWMMKDPIINFRYSYRYLVDVITVKNNKLAELSDVGDLPVLLLHGKEDRNVYLQVSEEFFKLLRTKRKNIEIFDCDHWFYDAMFYIQSSTYTEESRMKFISSLVTWMRSLDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP13</accession>
    <name>K0IP13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34090"/>
    <dbReference type="EnsemblBacteria" id="AFU60324">
        <property type="protein sequence ID" value="AFU60324"/>
        <property type="gene ID" value="Ngar_c34090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34090"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3405"/>
    <dbReference type="HOGENOM" id="CLU_023842_2_0_2"/>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3410-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="115"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="495" mass="54710" checksum="258F758AA9A7EC84" modified="2012-11-28" version="1">MTFESKRPVSIGEYVILNYGKGKVLGLVESSSISSDALGNGIRNYEEAHESKIVASENRRDKSFKGHVRILGYLDELKRCKAILPALPPEPGTEVYEASAQDLTAIFAPAGDEWIRIGTLLRNTEVDARVNVDKIVSRHLAVLAMTGMGKSNLVSLLAKEIARINGTMVVFDYHDDYSTLDMGNNNSNLMDARINPRLLSADKLAEVIEIQENASNQMHVLRVAFTEEVKQRKGDDFWDALINAVAAAGADKAYREAAAKVVDKIDDARRKFHNILDPGMSDPLALVKNGKINVINLVELTERQANIAVSFYLEELLDDRKKATRQKKGHVKSPPMFPAPVLVVIEEAHVFIPRDEDTDTKYFASKVAREGRKFGLGLVIVSQRPRGIDANILSQMGSLAVMRMIQQDDQAHVSAASEALSRDLIDQLTSLNPGEAIFAGQWVNLPTFVKVDEVKERKIGGDQKAVEEWSRLAAMKQVAKESSESYVPSGYIHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP23</accession>
    <name>K0IP23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60374">
        <property type="protein sequence ID" value="AFU60374"/>
        <property type="gene ID" value="Ngar_c34590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34590"/>
    <dbReference type="HOGENOM" id="CLU_2340276_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3460-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10822" checksum="989E81EE50FF2188" modified="2012-11-28" version="1">MGLSDGDRKELESLIKAAANDPKVPIGLARKMVPTQGDIEDFAYGLVSGMVIGNFIAQFQNRNGRQPDRDETADILSIMMIRMPRLRMSIMKALDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP33</accession>
    <name>K0IP33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative CMP/dCMP deaminase zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c35110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35110"/>
    <dbReference type="EnsemblBacteria" id="AFU60424">
        <property type="protein sequence ID" value="AFU60424"/>
        <property type="gene ID" value="Ngar_c35110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35110"/>
    <dbReference type="HOGENOM" id="CLU_047993_2_3_2"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3512-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="19208" checksum="EE9D4322DD7D1647" modified="2012-11-28" version="1">MQRPDWDTYFMLQAEIAKLRSNCLTRHIGAVIVKDNRQIATGYNGTPPGIKNCFEGGCPRCMARLKGEIKSGEGLDRCLCTHAEANAIMQCALFGNAGSTRGATLYSTFAPCIECSKMAISVGIKRIVVIADYPEDGTQLLKEANVELVKLDTERLKPWLTIIPADPESSAKAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP37</accession>
    <name>K0IP37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative spherulin 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35310"/>
    <dbReference type="EnsemblBacteria" id="AFU60444">
        <property type="protein sequence ID" value="AFU60444"/>
        <property type="gene ID" value="Ngar_c35310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35310"/>
    <dbReference type="HOGENOM" id="CLU_423699_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3532-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="646" mass="69691" checksum="DD45388090BFD283" modified="2012-11-28" version="1">MKQSSIRFVAGALALLLMVPAAAGINSGNNMQAADAATATGIMVPLYTYPGGTWNRVIETKNDHPDVPVVAIVNPASGPGGSRDSNYVSGIGKLKDAGVIVIGYVSTAYTNRALSAVKSDIDKWASWYDIDGIFFDEQTNWAGKEWYYTQAGDYAESKGLDFTVGNPGANSIPSYLDTVDVVLIYESPGLPNLNNYQSWSSYDNGKLGMIPFGVGSLPTNWINNAAKLVGWIYVTNDVLPNPWDSLPPYYDEMTALLDNGSTPEEPGPNPSVPKYTLTVRSVDQDGKAINGMWMEVKKAGGSTIRTGFTPLSLTLEQGTYTVSAANYKQIIFDHWSDGTTQSSTISVNLSANTEITAHYNNGEAPSPPQQPSTVTLTVNTVDSAGEAINGYYTTLSQNGATIKTAFSPASFTLNSGQTYQVAVADYGDYVFDHWNDGSTTRQKTVTLQQSATLTAHYKSKTTEVPLQEEATLTVTSVDLSGKTVTGLWTVIKKNGATVKTGYTPLTYSAQVGSTYEVSVANYKNYVFDHWESGSKSSTRQVTVNADTTLTAYYNTRSSKMTITIKSVGLDGSPITGLWTVISGAGSATGFTPLSYTANIGSQYTITMGEWQNYRFDHWDNGSTSRSRIITPDGNNSNIVLTAYYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP42</accession>
    <name>K0IP42_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60469">
        <property type="protein sequence ID" value="AFU60469"/>
        <property type="gene ID" value="Ngar_c35560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35560"/>
    <dbReference type="HOGENOM" id="CLU_1529154_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3557-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="20023" checksum="85669A64C6B31E49" modified="2012-11-28" version="1">MRPYYTKKKRFPLRPVNITSAVSIFIFAMIYGLIEHMLLASPLGISVLTYPMNIHLAGQLYLYHVIMLIMAILVSFNPFFDRLIFRTSRNIRLQGLLWGTGNILNFVWLEDMFYWVLFGEWPKDVMTPLHISFYGIVWWYPVAFGGALFLYYLTSRIIRKMPVVPEQLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I751</accession>
    <name>K0I751_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57096">
        <property type="protein sequence ID" value="AFU57096"/>
        <property type="gene ID" value="Ngar_c01460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01460"/>
    <dbReference type="HOGENOM" id="CLU_2203996_0_0_2"/>
    <dbReference type="OMA" id="NNGKWER"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-146-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_3" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="11866" checksum="4B52E13E6F92B71F" modified="2012-11-28" version="1">MVSFEPAPGEKVILDEDCAEDKLRSGFLFLTDRRLVFQKTQGRMATLSKKEGEVVVDIPLNKISSVRAEGFLVKKLVVVSGDKTYKFGVFNNGKWERQIKQLTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7K7</accession>
    <name>K0I7K7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57231">
        <property type="protein sequence ID" value="AFU57231"/>
        <property type="gene ID" value="Ngar_c02830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02830"/>
    <dbReference type="HOGENOM" id="CLU_1880967_0_0_2"/>
    <dbReference type="OMA" id="HHIAHIF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-283-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="14647" checksum="B01947242C29919E" modified="2012-11-28" version="1">MQKGSRGEPVQESVSKPILLGLITALVIGIVAPIIMPHMTHPSMIYHIMLHIASLTIAVFLSIVSVIAYGRSTGPRLLFMMLGFMALALVEFLYLLDATAIVSVFDFSTLGIELPHVIILAMLAMFGLGVLRVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0I864</accession>
    <name>K0I864_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase of the metallo-beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05130"/>
    <dbReference type="EnsemblBacteria" id="AFU57456">
        <property type="protein sequence ID" value="AFU57456"/>
        <property type="gene ID" value="Ngar_c05130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05130"/>
    <dbReference type="HOGENOM" id="CLU_031965_0_0_2"/>
    <dbReference type="OMA" id="HGYHPDW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-511-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="499" mass="57660" checksum="DD90E846DF1A4C7E" modified="2012-11-28" version="1">MTKDTKITFYGGIHEIGGNKFLVEDKGTRIFLDFGMQMGKVNDYFSEFLKPRALNGMGDLFEFGLLPKLKGLYRQDYAKHMGFGGKEETAFDALVLTHAHVDHAAYIHYLRPDIPVYCSEATKLILQGIEDTGGKDDYLTFKHNFRIYENKKGEMSRGKGEDYQEPRKISVFENAKKFSIDSIEVEPLAVDHSLPGVTGIILHTSKGSIGYTADIRYHGRRASDTERFVERCGNSDIDVLLCEGTRVEETFSATEFSVEQDVKTIVNKTKGLVVCTYPTRDLDRLLSFYNAAKESERDLVIDLKQAYLLKLFQTSDQWKNVFPKPDDKRIKVYLPRKSWGLVGRDDISRYWTEKQLLQDYDVWEREFVDYGNAVNYRDVSGKQKNYIFYCNDYQLQQLIDVRPIEGSSYIRSQTEPFDDEMELKEERVKRWIEHFGLITSEKDWIHTHVSGHGSGDQIKKVIEGTDAKSLVPIHTEHEEYHRKWHDNVVNAQWNGSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8B6</accession>
    <name>K0I8B6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="10">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="10">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">hppA</name>
        <name evidence="11" type="ordered locus">Ngar_c05730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05730"/>
    <dbReference type="EnsemblBacteria" id="AFU57516">
        <property type="protein sequence ID" value="AFU57516"/>
        <property type="gene ID" value="Ngar_c05730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05730"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.548"/>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_2"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="10">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="697" mass="71739" checksum="A9C77923B9D7DDDF" modified="2012-11-28" version="1">MAFEDMLPIGASIASMAVAAGLAGWVGRQHSGTEKMMSISSAVRTGAMAFLRREFKIVIPVAVALAVIIGFASGFSNGAAFAVGAALSGLAGLIALRITVKAAVRAAQATSKGLGPAFAAAFRGGATVGLSVPAMALIAITVLFFVFPDPLTIAGVGIGASLIALFIRAGGGIFTKAADLGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDAAGMGSDVYESYIVTILAAMLLGALIVPTSLQAIGGDRFALTTLPIIGIEVNPLVIYPMLIGASGLIASIIGAMTITSRKISDPMKPLDIAFMVSAAIAIALNFFFTTSFLGYNVLSYALFATTVVGVILVPVIQRITDYYTNYKYKPVKEISDSTKWGYASNTLAGIIMGMQSTGPFMLSIVVVLGISYGITFGITQDPLVGIYGTAMAAMAMLSLAGIVLCIDAFGPISDNAGGIVEMTGMGEENRAITDKIDAAGNTTKAITKGFAIASAGLAALAMIQAFQHEADKIFPAMTFEYSLSDVGLVIGLLIGGLIPFFVTSQLIAGVSRSASKMVDEVRRQFKEIPGILDGKATPDYAKCVDIATGASLRELWKPALVTVAAPIITGILLGPTAVAGVLMGAVVSGLFLAYHLANSGGAWDNAKKYIEMQGKKKTEAHAVAVVGDLIGDPYKDTAGPALNTVIKLLNTVAIVFVPVFIAILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8E6</accession>
    <name>K0I8E6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57551">
        <property type="protein sequence ID" value="AFU57551"/>
        <property type="gene ID" value="Ngar_c06080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06080"/>
    <dbReference type="HOGENOM" id="CLU_3057246_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-606-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5866" checksum="CE89987A20DF596C" modified="2012-11-28" version="1">MWTSRSCIINNNDKKFADIGLFFEGTIDIFLFRNLGLVSRAEQQIGGAKNSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8G5</accession>
    <name>K0I8G5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dys1</name>
        <name evidence="2" type="ordered locus">Ngar_c06230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06230"/>
    <dbReference type="EnsemblBacteria" id="AFU57566">
        <property type="protein sequence ID" value="AFU57566"/>
        <property type="gene ID" value="Ngar_c06230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.600"/>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="320" mass="35817" checksum="84AB07A2004DCB3C" modified="2012-11-28" version="1">MAGRAKKDKELLRSPVRDYSIEQNDDVNSIFSSMTRSGGFESRNLADGVDILRRMIDDKSCTKFMSFVGALMSTGARGIIRDMVRNKMCDVIITTCGALDHDIARAYDKYYAGDFRMDDGMLLDKDIHRLGNVLVPMGNYGPLIEEKIQKCLADMYKEGKRSVSTYEITDYIGSTLDKSSFLYWAHKNRIPVIVPGIVDGAVGSQVWFFYQQHKDFKVDILKDQSKLSDIVFEAKRSGAFMIGGGISKHHTLWWNQFRGGLDYAVYITTAPEWDGSLSGALVAEAISWGKVTAKARQVTIHGEATTLLPFIYAALIKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8I6</accession>
    <name>K0I8I6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57591">
        <property type="protein sequence ID" value="AFU57591"/>
        <property type="gene ID" value="Ngar_c06480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.626"/>
    <dbReference type="HOGENOM" id="CLU_200516_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-646-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="48" mass="5240" checksum="F0CB0DE998FEAD41" modified="2012-11-28" version="1">MATEAYCVKCKAKRTMKDEKKVTMKNGKPATQGVCPVCGTKMFKIGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Y1</accession>
    <name>K0I8Y1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57716">
        <property type="protein sequence ID" value="AFU57716"/>
        <property type="gene ID" value="Ngar_c07740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07740"/>
    <dbReference type="HOGENOM" id="CLU_3338593_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-772-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4316" checksum="67DB8A7849FEABDC" modified="2012-11-28" version="1">MHSYRQLRPCDRMKNRFSPLIACLPGVLLLICIPFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I984</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
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            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57891">
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        <property type="gene ID" value="Ngar_c09490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09490"/>
    <dbReference type="HOGENOM" id="CLU_3148094_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-947-MON"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="48" mass="5715" checksum="6787080FC1AE6FA8" modified="2012-11-28" version="1">MLARSMQDVPFDLQHIRCIIYEDSSDGRKKLERDLSNMIRQILHDKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9X1</accession>
    <name>K0I9X1_NITGG</name>
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        <submittedName>
            <fullName evidence="6">PQ loop repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c11860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
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            <taxon>Nitrososphaerales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
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            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Ga9.2</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFU58126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58126">
        <property type="protein sequence ID" value="AFU58126"/>
        <property type="gene ID" value="Ngar_c11860"/>
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    <dbReference type="BioCyc" id="CNIT1237085:G1324-1184-MON"/>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10356" checksum="77DBC4D6627BDEE2" modified="2012-11-28" version="1">MEIDTIVGISAAILTMSSFIPQIIKAIKTRSMEDVSVYLMPLFIVGFSLWVAYGFMQDDPVIIGSNITGIAFNTTLLFLKSRYKMTERRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA66</accession>
    <name>K0IA66_NITGG</name>
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        <submittedName>
            <fullName evidence="9">Excinuclease ABC, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uvrC</name>
        <name evidence="9" type="ordered locus">Ngar_c12610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
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                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
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            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFU58201">
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        <property type="gene ID" value="Ngar_c12610"/>
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    <dbReference type="PATRIC" id="fig|1237085.11.peg.1207"/>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_2"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
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    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
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    </dbReference>
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        <property type="entry name" value="UVR_dom"/>
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    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
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            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="542" mass="62139" checksum="D1579E2432A44B50" modified="2012-11-28" version="1">MVAATTILKEKRMPDEPGVYLMKDSDGKIIYIGKAKNLRKRVTSYFTKHDPDVGWKTSRLVNKIADIEFIVTDNEIEAFLLESNLIKRYRPVFNIELKDQQRYTYLKITDEPFPRLLVARRNRNGEFLGPKGKVYGPFVRGSSKFLTVGLLRKLFKIRICNRLPKTPCLQYFIKNCEAPCIANVTRGHYMMNVMALQDILEGKSSIDKFANNMEDEMKRASDLGDYERAKEIRDTLYRLNNLRVKQKMEKAVNRNPDEEYISIMRDNKKGIAHVMALRRTRGVISDRKKFEFDLVGDNSLSSFLVQYYSSVPVIPRFLYVNEDLDDRQVLERSLEKIAGHRVSIFNIRHVLAKEKRQLMDLISRNLSMYIERGYDPAVVELKNAIRLLSMPEVIDCFDVSNLGTSIAVGSCVRFANNKPAKSSYKKFRIRTVAGQNDFAMIGELVRRRYHSAGDDEKLPDLIVIDGGHGQLGAAVASLRSLGIHDVPCIGLAKENEEIYMPGLQEPIVLPKSNAGLKMLQHARDEAHRFGLAYNVNLRKLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB92</accession>
    <name>K0IB92_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c16480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16480"/>
    <dbReference type="EnsemblBacteria" id="AFU58581">
        <property type="protein sequence ID" value="AFU58581"/>
        <property type="gene ID" value="Ngar_c16480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16480"/>
    <dbReference type="HOGENOM" id="CLU_006033_3_4_2"/>
    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1646-MON"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="21224" checksum="D6A2C84B0CF19B26" modified="2012-11-28" version="1">MDSRKELVDCVKSLYGMGLTTPVSGNHSIRSGGSLMWITPSGVPRYRMRPADLVRVDLKTGKAIGRSKPSIELGMHRSIYNVRPDINAIVHVHSPFTIGVSISAKRFWHVIGEAKMVVGEPAVITNRPSGSAELAKAVSDEFKKGARAVVIKNHGVVAGGSDIDHARAIVESLEEWAKILTIAQVFGGVSSWLDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBC3</accession>
    <name>K0IBC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16680"/>
    <dbReference type="EnsemblBacteria" id="AFU58601">
        <property type="protein sequence ID" value="AFU58601"/>
        <property type="gene ID" value="Ngar_c16680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16680"/>
    <dbReference type="HOGENOM" id="CLU_999656_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1666-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="32150" checksum="B94D6022C24C17F5" modified="2012-11-28" version="1">MSAADTRDLKSLGWDELVALKRKLAGELKEITDKIVEIDRNKLRAITDNIKEQRSILDVHTERLKQVRSEVEKRNAELLAVSEKISQSKNFLSMMEARLPPEKEEELQATVQNNQALLDTKDYKSEREKNEILSRLKEASMKMEAIKATRTIKDQLAQLTHESAGISSAIRRLDEERDSLRAKISEINSALDKLYDSKRKLAPERDLHLAKYDEIAKQFDAINARLDAMSEMRKRQREEYGYGLPSDALFKVKEEARKKLEAGSKLSFEELKLLYGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBS1</accession>
    <name>K0IBS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00600"/>
    <dbReference type="EnsemblBacteria" id="AFU57010">
        <property type="protein sequence ID" value="AFU57010"/>
        <property type="gene ID" value="Ngar_c00600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00600"/>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OMA" id="NDEMICS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-60-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="15444" checksum="656E973FF8A9BCBC" modified="2012-11-28" version="1">MALSSTTICLDTDFLINSIKKDPKTQAKLDELEERGFTSLSTTVINAIELYIGAYRSKNREQKIAKVASMIDRLHLLTLNHKSSQLVGEITYELRSNPIGEKDLLIAAIVKENGQILITRNTKHFEKVRDLKIESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBU3</accession>
    <name>K0IBU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58746">
        <property type="protein sequence ID" value="AFU58746"/>
        <property type="gene ID" value="Ngar_c18130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18130"/>
    <dbReference type="HOGENOM" id="CLU_2490569_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1811-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9908" checksum="11924E21B8E57337" modified="2012-11-28" version="1">MDLIEESTKILSAALEGASRARIAALQQHLKHNEIEWLLKMLVDRKLLEMDSTSSSAYYWTTVNGVKLLEIRFNMERMLQAQKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBX1</accession>
    <name>K0IBX1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58791">
        <property type="protein sequence ID" value="AFU58791"/>
        <property type="gene ID" value="Ngar_c18590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18590"/>
    <dbReference type="HOGENOM" id="CLU_208209_0_0_2"/>
    <dbReference type="OMA" id="HYSAHIK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1857-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6080" checksum="5E35873748F56FD8" modified="2012-11-28" version="1">MPFKEIYCSDCKTVLARYSTKYFTDADINELVHLHYSAHIKDGHSMETRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC06</accession>
    <name>K0IC06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01350"/>
    <dbReference type="EnsemblBacteria" id="AFU57085">
        <property type="protein sequence ID" value="AFU57085"/>
        <property type="gene ID" value="Ngar_c01350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01350"/>
    <dbReference type="HOGENOM" id="CLU_2662483_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-135-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMMBL" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8841" checksum="EE3445B349B185BE" modified="2012-11-28" version="1">MSQERVNNWLDKFGMERHQIYCSGHAKGTDLFQIVKEISAKMLFPIHTEHPEMYVRATRNMTVIEEGKAYDLLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC89</accession>
    <name>K0IC89_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="2">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">truB</name>
        <name evidence="5" type="ordered locus">Ngar_c02060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02060"/>
    <dbReference type="EnsemblBacteria" id="AFU57155">
        <property type="protein sequence ID" value="AFU57155"/>
        <property type="gene ID" value="Ngar_c02060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.206"/>
    <dbReference type="HOGENOM" id="CLU_032087_3_0_2"/>
    <dbReference type="OMA" id="GPFKEDE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DKCLD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="3">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="355" mass="39658" checksum="51CD95CF604E553E" modified="2012-11-28" version="1">MNLPQLENLVKVDDDVTNDNYGHYPDRRPIESLLYYGLVLVDKPAGPTSHEVVAWVKRILEIEKAGHSGTLDPGATGLLPLGLGEGTKALSVLLLGPKEYYALARLHSHISVDRLKRVMQEFTGEIYQRPPQRSSVRRVTRVRTVYEFDYLENYDRLVLMRILCQAGTYIRKIIYDIGEVLSPGATMVELRRTRVSNLSEQNSGGLVKLHDLADAYQRYKESKDDEKLRRLILPIEHCLEGIRAVTVRDTAVDALCHGAPLAVPGVVAVPKDLRVGELVGVYTLKGEVVGLGQAAMTKEEIEQNARGIAFAMKRLIMKPGTYPKAWRSKGEQAAVVNVPTEVDLDRLENEHADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICN5</accession>
    <name>K0ICN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57395">
        <property type="protein sequence ID" value="AFU57395"/>
        <property type="gene ID" value="Ngar_c04490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04490"/>
    <dbReference type="HOGENOM" id="CLU_3039174_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-448-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6159" checksum="1B5ED4550A0AE367" modified="2012-11-28" version="1">MYDEGLVCFRCKGLGAKREIYDREEGPSDSSSFSDIYLGSINYKKMRKKNIDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICU1</accession>
    <name>K0ICU1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57480">
        <property type="protein sequence ID" value="AFU57480"/>
        <property type="gene ID" value="Ngar_c05370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05370"/>
    <dbReference type="HOGENOM" id="CLU_1648358_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-535-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="17307" checksum="0466AC0DF72C2DCB" modified="2012-11-28" version="1">MSNSITVPVIAGLAVGVGFFILFSLSLAGTPKEPIMYLITADGNGHRAYNNVYCGEACDFLAYARVAPRNTPTIHIDKDSDFGLKTTNTPEQPIAVMFIVQSPENGSSSGSGTFSLPMRNGNYFAGSLESGEYILSVIAEWDNEQPNLIRSLHQFKVVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID22</accession>
    <name>K0ID22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23510"/>
    <dbReference type="EnsemblBacteria" id="AFU59276">
        <property type="protein sequence ID" value="AFU59276"/>
        <property type="gene ID" value="Ngar_c23510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2325"/>
    <dbReference type="HOGENOM" id="CLU_2406201_0_0_2"/>
    <dbReference type="OMA" id="KIWKPEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2349-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9349" checksum="1E22E6425956989A" modified="2012-11-28" version="1">MKALTLRDISDIAAIKEDIKKHMIVILKVTPLAQKDVEELRKVVEELYSYSQSVGGDIARLGEERVVITPPGVKIWRGAYDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDA9</accession>
    <name>K0IDA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07070"/>
    <dbReference type="EnsemblBacteria" id="AFU57650">
        <property type="protein sequence ID" value="AFU57650"/>
        <property type="gene ID" value="Ngar_c07070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07070"/>
    <dbReference type="HOGENOM" id="CLU_047974_0_0_2"/>
    <dbReference type="OMA" id="LPHLDYC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-705-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="437" mass="49198" checksum="67D24294D5842724" modified="2012-11-28" version="1">MVAPEYSIVLDIVGLEVEHLNSGLVPNIAKIANDGEYAKLEPVFPAVTCTVQASLLSGKYPNEHGIVANGLYDRNAYFVSFWEQPSSLVRAERIWDRRNSCTSAVLFWQNTMYANSDIVVTPRPIHLDDGVVMWCYSKPVGYYEELRDKLGEFDLASYWGPLASPRSSEWIANAAEYTLEKHRPNQLFAYIPHVDYSVQRFGKSDARARDDLKKADDIVGRLVQKTSELGIKDKTQFIIISEYSFNDVQGAIPLNLVLRDAGLLAVREIQDKEYLDFEFSKAFAMVDHQAAHIFVKDGFERAARKILEATAGIDKVLDSEGKKRLKIDHERSGELVAIAERDKWFSYYWWHDEKKAPAFARKVDIHRKPGYDPVELFVDPKTKSIPLDASLVRGSHGRPADLETGEGLAFYASSSKHDITKSGIAKCTDIIKCLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDJ8</accession>
    <name>K0IDJ8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ordered locus">Ngar_c25540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25540"/>
    <dbReference type="EnsemblBacteria" id="AFU59476">
        <property type="protein sequence ID" value="AFU59476"/>
        <property type="gene ID" value="Ngar_c25540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25540"/>
    <dbReference type="HOGENOM" id="CLU_042266_0_2_2"/>
    <dbReference type="OMA" id="REYMADS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="79"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="299" mass="33065" checksum="9147211C1D9183F5" modified="2012-11-28" version="1">MYTKKAPWKKRDNGLTARIIVSFAVLTILYIIFLSVLAYVGFGAIPIAVIAGIMILAQWYFSDKIVLWSTGAKIVSREQFPELHDLVERIVARNNLPKPRIAVVNTQIPNAFATGKTPKSSIVAVTLGLMDQLETEELEAVIAHELAHIKNRDVLVLTLASLFSTVAWYLMRFSMFGGMYGGGRNRDSGGGLALVLIVAIITWFVSFLIIRAISRYREFVADRDGALMTGKPSKLASALLKISGKMKRIPTRDLREVEGMNAFFIIPALSGDAFASLFSTHPPVDQRVKKLMEMEAAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDM5</accession>
    <name>K0IDM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57790">
        <property type="protein sequence ID" value="AFU57790"/>
        <property type="gene ID" value="Ngar_c08480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08480"/>
    <dbReference type="HOGENOM" id="CLU_122242_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-846-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="16421" checksum="DA623DFB395186BE" modified="2012-11-28" version="1">MSSANSDASLTDNTKTGLTPEQTAENIKNIARTIRNSSTRLRDTIRTLRESGAINEIAEAIREASAAARDTAKEINETAKDLKERGVISDTAGAVEETTRMAQDTVKTVRETAREAAEAAPQTTEAVRKGAETVKQKSRETMEKARKEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDM8</accession>
    <name>K0IDM8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative universal stress protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59501">
        <property type="protein sequence ID" value="AFU59501"/>
        <property type="gene ID" value="Ngar_c25800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25800"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_4_2"/>
    <dbReference type="OMA" id="ETFYERI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2579-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="19127" checksum="1FF620928B7F0FAA" modified="2012-11-28" version="1">MSSQAQQRPQEVKERGRNTSARFKKILVAVDGSEESFKAAQYAIELAKKERERAQLIVLSVNETPSSLISTIEPSALERWRERLKAQSETFYERIVSTYGLDIEDNSELQLRAEMIDSAKSAYVAIVEYAEKEDVDLIVLGTKGKTGLKRILLGSVALGVVTHATCPVLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDN7</accession>
    <name>K0IDN7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57815">
        <property type="protein sequence ID" value="AFU57815"/>
        <property type="gene ID" value="Ngar_c08730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08730"/>
    <dbReference type="HOGENOM" id="CLU_817885_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-871-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="339" mass="35684" checksum="AA20210D5D561662" modified="2012-11-28" version="1">MRFRKTPVAIMLAVLAGGIISQIPSALGDNSDNNPFGALWDAIFDLQIKDKNLQAQIDELRAERDDGLSSAQTDEPVALASDAYARIRVESAAEGDGQSIVYITAGNNGPDRAAGIKLTTFYLMQLFQINSIDSGGDGLCEDKSRGIIECTLGTLEAGQESLITIHATAKEYGKANTWTVDISTTTKDTDYTNNHVTYDFETGSAATPIKQQQILPPAEQQQQPPTESGIDEPQESEPEQNGLDNNNSSNSTDADTSSEQTADNDSANQTSAETVPSTGSNGTGTEEGNSSEEEASKEEQTASSSSSSEESNVEGSGSSSNSSSDEGSEEPVSNNNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDU8</accession>
    <name>K0IDU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57910">
        <property type="protein sequence ID" value="AFU57910"/>
        <property type="gene ID" value="Ngar_c09680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09680"/>
    <dbReference type="HOGENOM" id="CLU_1154377_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-966-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="240" mass="27862" checksum="78078FCC1BC58C22" modified="2012-11-28" version="1">MVLEVLVFMLSLNCTEDFESNYWEGFDSAMIDEWNIIMTTTSCYQLDEFPSDFSDYRDLKEEAIIAAAVAAAQENNNNNDDVDDTDNNMMSSDIITIVHHPVDFTTYFDKLLLFLSNHSTNDNDDSEEQQKERQKQQQVVFITQYSKAVFQIENAAGVSYPSENIAFVRSDLFYTTKSLSHEILHLVLEEEGYPKGCYIDKVHENHFKPSLKKVAKDDEDNDNNYMRSAYYYQIIARFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDW4</accession>
    <name>K0IDW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09980"/>
    <dbReference type="EnsemblBacteria" id="AFU57940">
        <property type="protein sequence ID" value="AFU57940"/>
        <property type="gene ID" value="Ngar_c09980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09980"/>
    <dbReference type="HOGENOM" id="CLU_1243058_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-996-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="237" mass="27690" checksum="D26995BA529B49A8" modified="2012-11-28" version="1">MIFARVDLKLKRKRTAGRQQYVKQLCDQEQVYGSLARFFDNARFQVLACLNSYVLTLTTDEEQLQAPKRAARARGVKLRYITDITKDNLAYCKRQMNMVDELRHLDGIRGNFILSDKEFMAAPDISQAKPLTEGIHSSDEKMLNQLRCMFETLWHHSVPAEARIRELELESEDIDYGIRHEPELDPDQISEHGRKRRSKVIDRFYVCARCGSVFVYMEDSEEHKVSTGHKEMKEFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDW8</accession>
    <name>K0IDW8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c10030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57945">
        <property type="protein sequence ID" value="AFU57945"/>
        <property type="gene ID" value="Ngar_c10030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10030"/>
    <dbReference type="HOGENOM" id="CLU_2581533_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1001-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8694" checksum="CCF7CDEBC00D8B5F" modified="2012-11-28" version="1">MNNNLPVVDAEISIEPIGTSDTSIGKETAAAYDAIRNIQNLKKVTLTPMSTQIESDNIDDIVQATTLPIIRPDLLREQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE27</accession>
    <name>K0IE27_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01230"/>
    <dbReference type="EnsemblBacteria" id="AFU57073">
        <property type="protein sequence ID" value="AFU57073"/>
        <property type="gene ID" value="Ngar_c01230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01230"/>
    <dbReference type="HOGENOM" id="CLU_122978_3_1_2"/>
    <dbReference type="OMA" id="QSARARX"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-123-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PTHR10840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="11085" checksum="9C93E23479E60904" modified="2012-11-28" version="1">MSVPQPHQPNDEEARRREAEAAMRQRVLQVVLDSQARQRLMNIRLVKPELATAVENYLISAASSGRINRPLTDEELKQLLLRIQQPKKDFKIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE39</accession>
    <name>K0IE39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57083">
        <property type="protein sequence ID" value="AFU57083"/>
        <property type="gene ID" value="Ngar_c01330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01330"/>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-133-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="15833" checksum="03209543D7D9AC26" modified="2012-11-28" version="1">MSAVSEIMSSPKKIVAASIKPGLSALDMAKLMIKNKVGSVVLMDGDERPVGIITERDILRKVAASNKPAKSIAAKDIMSSPVITVKAFDSIETAAAVMTKNKIKRLVVVEQDDSLAGVLSVTDIARKLAKILADDYNRYGHLKAILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IET6</accession>
    <name>K0IET6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argD1</name>
        <name evidence="3" type="ordered locus">Ngar_c13370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13370"/>
    <dbReference type="EnsemblBacteria" id="AFU58275">
        <property type="protein sequence ID" value="AFU58275"/>
        <property type="gene ID" value="Ngar_c13370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13370"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1293"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="411" mass="44609" checksum="90A56F715AF2A819" modified="2012-11-28" version="1">MGSKIVTEPPGPAARRIIDVMKRNCYDSTFTYPLVIADGNGSFLHDVDGNSFLDFTSNIGSCPLGYSHPEIMQVLAEQAKNGAHKIAGQDFYCKEHAELSERMISILPQGFRTFFINSGAEAVENAIKIAYRKMSTTTPSSLPGVSCVNAFHGRTLGALSFTFSKPVQKKGYPELPVLRIKFCTSDSDAEIDAAERLLAENKVAFILSEVVQGEGGYNVASKKFIQNLRRCADKYGVPLILDEVQSGMGRTGKWWAFEHYGVKPDIMSAAKALQVGIAAYDSRLDPGEQGALSSTWGGGSRIDMAVGAKIIEVIRKDRLLDNAAAMGVKLKKGLQELAGKGGMIDVRGLGLMIGLEFDSKQNRDERLARAFKKGLLLLPAGQKAMRVIPPLTVTEEEVQEGLGLMRQVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEX6</accession>
    <name>K0IEX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c29930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29930"/>
    <dbReference type="EnsemblBacteria" id="AFU59911">
        <property type="protein sequence ID" value="AFU59911"/>
        <property type="gene ID" value="Ngar_c29930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2965"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_3_2"/>
    <dbReference type="OMA" id="HVITHTV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2993-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="15341" checksum="B60097B27923D1C1" modified="2012-11-28" version="1">MSSANIDETDEKILHIMQADSRKAFVEIANEIGLSESAVRRRVKNLVDSGVIKRFTIELGASDKTSAITLISVASTADTSAVSNRLMKLGGVEVVYEITGQYDIAAIIAAPSIAEINKCIDDIRKIEGVSDTNTVIILKTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF97</accession>
    <name>K0IF97_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl-transferasse</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15410"/>
    <dbReference type="EnsemblBacteria" id="AFU58475">
        <property type="protein sequence ID" value="AFU58475"/>
        <property type="gene ID" value="Ngar_c15410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15410"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1505"/>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_2"/>
    <dbReference type="OMA" id="DTFRDWT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1539-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="234" mass="26656" checksum="C48235448E452471" modified="2012-11-28" version="1">MKAVILAGGLGTRLQPYTFFIPKPMLPLGNKPLLEYIIEWLKNSGGIDHIVICVSYLHRTIEDYFEDGARFGVEIEYARSERPLATAGQLKTAEKLLDEPFVCVYGDSVYEFNLRKMLKEHRESKAFVTMALLQYSTKLKYGFIDLNGQEKVTAWREKPEISGLINIGCYVMEPEFLKIIPKSGSFGMDDAVRKVLEQKKTVKGFRIDTGFIDIGDKKSYLDAYKQYASRLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFM7</accession>
    <name>K0IFM7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58615">
        <property type="protein sequence ID" value="AFU58615"/>
        <property type="gene ID" value="Ngar_c16820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16820"/>
    <dbReference type="HOGENOM" id="CLU_1682757_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1680-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="18851" checksum="E3A5A2BE96E02E90" modified="2012-11-28" version="1">MPNNNMVPAGLSARIVFSKPYIALAATVTVGFWIIFNALDGLLLFSPSLDFYYPIPQDAIPGFVLANITVPLIGIIVSMNVYIARNSKSGASRSSSSFFSGSALGTVSSVCAGCSSVGFYLATTFGTAGVAASTILSNYQLPLRLLAIGLLVLAYYSAHRRITKSCVVKYNDDDNNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFY9</accession>
    <name>K0IFY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60316">
        <property type="protein sequence ID" value="AFU60316"/>
        <property type="gene ID" value="Ngar_c34010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34010"/>
    <dbReference type="HOGENOM" id="CLU_3282987_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3402-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="40" mass="4574" checksum="E482ECCA2E8C2469" modified="2012-11-28" version="1">MQDLAEAAEGLEPQRASYMHFKRLCKTASDQKALRYCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGU6</accession>
    <name>K0IGU6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blue (Type1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11260"/>
    <dbReference type="EnsemblBacteria" id="AFU58068">
        <property type="protein sequence ID" value="AFU58068"/>
        <property type="gene ID" value="Ngar_c11260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11260"/>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="OMA" id="VRWINND"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1124-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="68"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17702" checksum="D5846283225E32BF" modified="2012-11-28" version="1">MSQITSNTAGIAITTFIIAVAVSMTYYQFMYIPEANKRPVLPKEILNPPEVTNVRILENSFLQSNPKNFEPKSVRGIIGVSNKVVWTNEDTFAHTVTSDEPTYIDQINGKFDSLAHGIVIGPGETFEFTFTKVGEYHYHCEPHPWMEGTIEIIENFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGV2</accession>
    <name>K0IGV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58073">
        <property type="protein sequence ID" value="AFU58073"/>
        <property type="gene ID" value="Ngar_c11310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11310"/>
    <dbReference type="HOGENOM" id="CLU_202281_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1129-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6283" checksum="4DCB59765D4CE8D2" modified="2012-11-28" version="1">MGEKSIVVRASNRSPSVRTTIPEKIVQEMEIAVGDVLDWETTMQGGRKVVRVKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH42</accession>
    <name>K0IH42_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22550"/>
    <dbReference type="EnsemblBacteria" id="AFU59185">
        <property type="protein sequence ID" value="AFU59185"/>
        <property type="gene ID" value="Ngar_c22550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2233"/>
    <dbReference type="HOGENOM" id="CLU_075478_0_0_2"/>
    <dbReference type="OMA" id="GNHDGGI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2253-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="31195" checksum="FB1950A56CA27126" modified="2012-11-28" version="1">MPLGRKSICLTLPDASASSIRDTDLFALCEYIKSVKIRPLHPHAALLLEEDDDRKYVAVSDLHIGLEAELLEKGVTMPSLASGMVSELLELVEREHVNGVVLLGDIKHTVGSISKQEWDEIPAFLKRLAAKADVYLVPGNHDSNIRHLVPTSVNVVSAKGMTLGGDTLLVHGHSMPSDIRSNVGRIVMGHVHPVFVKKGSVINGQRVWIYIQGRKEALFPSQEGTIEVVVVPSFNPHLYATEERWYHKPISPIITRVVEAGVEKCIVATLDGSVVGDVDVLPHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA6</accession>
    <name>K0IHA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58263">
        <property type="protein sequence ID" value="AFU58263"/>
        <property type="gene ID" value="Ngar_c13250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13250"/>
    <dbReference type="HOGENOM" id="CLU_184936_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1323-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9044" checksum="296B4351077D0E10" modified="2012-11-28" version="1">MNITEGEDTLIEARTCGDKNKRVAYKFMDGFHSLCLDKRDILLAEIGACEMLLRACHDEADRIAVEKEIAELKMALDLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHG2</accession>
    <name>K0IHG2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14010"/>
    <dbReference type="EnsemblBacteria" id="AFU58338">
        <property type="protein sequence ID" value="AFU58338"/>
        <property type="gene ID" value="Ngar_c14010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14010"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1364"/>
    <dbReference type="HOGENOM" id="CLU_107614_2_0_2"/>
    <dbReference type="OMA" id="ANPYVDI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1399-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="18270" checksum="D51C3F20B8C49901" modified="2012-11-28" version="1">MRKLQISVIGYNKDCTENARKVAYEVGKEIAKAEAVLVCGGLGGVMESACRGAKENGGTTVGIIPQEEFSYANQYCDIVVCTGIGYARDFIVASSGDGIIAVGGGVGTLIELGVGYMTKKIIVAMAGSGGVADMYGGKFLDERKRAQIVIAKDAKEAVQVILEKYHNWQKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ3</accession>
    <name>K0IHJ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03290</name>
        <name evidence="2" type="ordered locus">Ngar_c03580</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57277">
        <property type="protein sequence ID" value="AFU57277"/>
        <property type="gene ID" value="Ngar_c03290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57306">
        <property type="protein sequence ID" value="AFU57306"/>
        <property type="gene ID" value="Ngar_c03580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03290"/>
    <dbReference type="KEGG" id="nga:Ngar_c03580"/>
    <dbReference type="HOGENOM" id="CLU_822874_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-329-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="337" mass="37764" checksum="A72979E7DF1DEDEE" modified="2012-11-28" version="1">MRAQNILHNEVLSIKEGESTPTKLPVGVTYGEIRIFVEGTYTLGTGVLHSDSPRQVFRNAKLEYNNANAIYSGKSKDFRIMNYYDQIGVEHFTAANGKFEALLRWNKGMILADESVLPAGHVHPFGKITQLNIDLTWMTKSDFFSTVGTATIDTAKAYISYDQIETTKSEIMQIFGDRLERYALPRVTAKQTDAKVANTELSEVLNVGSGNLHKRAFVTTFDNANPAVEQDDRIEKYQVKRTLPVSDAKELITARYKAAQADDKSFYKFGTALKGTFAIDYDKEVSMDGRGILVESKEEALKLLAKIDNPTVFRYVSEEYVVNREHVQSGGKLVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP1</accession>
    <name>K0IHP1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative CRISPR-associated protein, Cas3` and Cas3`` domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cas3`</name>
        <name evidence="12" type="ordered locus">Ngar_c03840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03840"/>
    <dbReference type="EnsemblBacteria" id="AFU57332">
        <property type="protein sequence ID" value="AFU57332"/>
        <property type="gene ID" value="Ngar_c03840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03840"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.370"/>
    <dbReference type="HOGENOM" id="CLU_009347_0_0_2"/>
    <dbReference type="OMA" id="WVFRDLG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="190"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="396"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU57332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="696" mass="81959" checksum="79842CC42723B91D" modified="2012-11-28" version="1">MYEWSELDQKLSHQGKTLLTHINEVKALGKDLLDFYGLNKEYHEILDYLAEYHDYGKRSNKWSINNDKNPPHSPLSVRYCIDNKCYFKEDTKLTNILWYLIFKHHGSLGDVIRDYNGVKPFIERRIIEKRIKELDFDHRVNLIDTFGLFKVADALSASNLQRFKMELPEVNEGIVKRIIGSVDARWNEQLRLSSLPSFGMLKAYTGWGKTSASLIFFMNKNASKIFYLFPTISAINQFYEKLNKEVGEKARKYFYFYDAYIEEPSSGASEDLDLVGNTLLTEYFLCPYIITTIDQFLLSFLQNGKYYRKRVMFRNAGIVLDEIHLLNPLMLTILVYFLKKYRQVYNLKFLAMSATFSSALKGYLSKELRLGDDCWLNFDEGFRRKRRIMFEYKNDDIEKHLDYVNSLSSKKVLIIANTVEKAVAVARKLDEMKKPYVLLHGRFMYRDRVYKEKKIEELKRNPHVLIATQVCEVSLDVSYDFMMTELSPVPSLIQRFGRVNRYGGRINETNVLIFRPDIKNEKYYPYSQDELKAFNEIEKFQGSALENEKQLIDQYDRIYTYDLLQKGIDRVYKEISFGSFEEILEFFFSLSYSEEELMRIMSYRESFTTLIIPHHECIDPGEKEKIAILRKALGKNMKTLDYGERNMLFREIKSLAVSVPIWWLKGLSVEEKIVCPVINFRDKVYNSTYGFVGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR5</accession>
    <name>K0IHR5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59480">
        <property type="protein sequence ID" value="AFU59480"/>
        <property type="gene ID" value="Ngar_c25580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25580"/>
    <dbReference type="HOGENOM" id="CLU_182719_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2557-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12353" checksum="A318A2E470BB6703" modified="2012-11-28" version="1">MRWKEEIGGRKRGRNWMSAMGILFMVSAAIILIRNIVLFYIDHSIGLVEDPAQLFLNNFVNNQVTNEKFAIAMIAAGCFLLYWGFFRKNEDYGPPDEHEWRRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS4</accession>
    <name>K0IHS4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25680"/>
    <dbReference type="EnsemblBacteria" id="AFU59490">
        <property type="protein sequence ID" value="AFU59490"/>
        <property type="gene ID" value="Ngar_c25680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2545"/>
    <dbReference type="HOGENOM" id="CLU_884552_0_0_2"/>
    <dbReference type="OMA" id="CTTVAHK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2567-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="317" mass="35088" checksum="8C3A3D197B104832" modified="2012-11-28" version="1">MAWKVMMPKKIMFGENAAKEFPYPKNSLVITTTTPDIYNKWLDYMGIKNYEVYDKVTPDPAIETVEAIKKQYEGKNIGAYIGLGGGSSMDVCKYLSKLTGIPKILIPTTFGTGAEMTTYAVISFDHKKKLLQDEAFLADAAIVDPYFLPGTPFNILRNSACDAAAQASEGYDSKAGNPFTQFFCKEAFDILYDAIMNDKHHLLPYGAMLSGIGFGNSSTTLGHALSYVFSNEGVPHGYALSSCTTVAHKFNKSIYYKRFKEIAQKLKFEPLKLKQPLDQAADVIMPDRGHLDNNPIPVSKQDIIQCLDEIVNSNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX4</accession>
    <name>K0IHX4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57502">
        <property type="protein sequence ID" value="AFU57502"/>
        <property type="gene ID" value="Ngar_c05590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05590"/>
    <dbReference type="HOGENOM" id="CLU_1607071_0_0_2"/>
    <dbReference type="OMA" id="IYTIARW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-557-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="18017" checksum="958484C87708E87A" modified="2012-11-28" version="1">MTKAAGFIRKYMDSILFNRNLIIAGAGSFFASAYVSELYAQYDSNDLANSALALVVEYGIYIPVFAMLFYINNRSKYVDPATGRRDSRQIMQDIKKLFAAFSVSEVIYSVTKVAMQYWLLQAGNQPYEASMASSLIAWGVFFVAINSMAKLVKLFKHHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0II05</accession>
    <name>K0II05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin-sulfite/nitrite reductase</fullName>
            <ecNumber evidence="6">1.7.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sir1</name>
        <name evidence="6" type="ordered locus">Ngar_c06440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.7.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06440"/>
    <dbReference type="EnsemblBacteria" id="AFU57587">
        <property type="protein sequence ID" value="AFU57587"/>
        <property type="gene ID" value="Ngar_c06440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06440"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.622"/>
    <dbReference type="HOGENOM" id="CLU_015667_1_1_2"/>
    <dbReference type="OMA" id="IKISGCM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048307">
        <property type="term" value="F:ferredoxin-nitrite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="134"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="347"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="425"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="613" mass="68196" checksum="075C978053978F7F" modified="2012-11-28" version="1">MRKSKVATEKGVSPPKPNPRWGREEETEIFAKKVKLFRQGKISEDDFRRFRLQHGAYGSRLHMDYSMVRIKVPGGEITPDQIEKIASLSEAFSIGSAHVSTRQNIQLHWVQLEDVSEVMRGLVEAGLTTREACGNTVRNVMCSHFAGVCPNEAFDATPYSKAIARFFLRNPMCQNLPRKFKINFACCDQHGLVRVADIGLVPAIREVENGTKVRGFKIYLGGGLGAASFIGHLLEDFTPEDRVLATCMATVRLFDRHGNRENMARNRMRYLVHEMGWERFQKMVLKERSIVEMTTSYSTAQLFDVKSQEDTRQLPKAPRMAKLPMLNEQLTKDSPAYERWLHTNVVPQKQEGYFTVFITLGAGDITANQLRVLASAIRDYSAEAVARNTPQQNFAVRYVRGTELRDFYEKLASAGLANPGALTIASTVGCSGTTSCNLAITNSHRLAKEVQRKFLELELDTDDSLRDATIKISGCPNSCGQHEIATIGFFGGATRMNNSMTPTYTMLFGGSAGEQGELGKAVMRVPAKRVIDAVLKVIELYKQQRSGNETLHQWVVNITRGKGTGAIKNLEDMKAALAQVIQLPAPDKDPDAYMDYGSDSRFSAKTARGECAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0II80</accession>
    <name>K0II80_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c07290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07290"/>
    <dbReference type="EnsemblBacteria" id="AFU57672">
        <property type="protein sequence ID" value="AFU57672"/>
        <property type="gene ID" value="Ngar_c07290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07290"/>
    <dbReference type="HOGENOM" id="CLU_128581_0_0_2"/>
    <dbReference type="OMA" id="GEYQIST"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-727-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld5" evidence="2">
        <location>
            <begin position="53"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20093" checksum="C194C71F643C6B17" modified="2012-11-28" version="1">MSTDARAEPRIEAIQNAYQLGYMAEEVRVSYKKDVRITVGNIDIDAKEGDMSSLQRWVAKILAEQGAVEIQSPDSAGYISRAMNRERIAKPHDLSGIDIDFYVRVNDYLEGLKDRERENLLVSLNTFVATRLEKIVKLAAASPLSPELEAKLSAEEKELYILINNASTKFKKGVLKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0II82</accession>
    <name>K0II82_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c07340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07340"/>
    <dbReference type="EnsemblBacteria" id="AFU57677">
        <property type="protein sequence ID" value="AFU57677"/>
        <property type="gene ID" value="Ngar_c07340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07340"/>
    <dbReference type="HOGENOM" id="CLU_068383_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-732-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="72"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="348" mass="37177" checksum="3F7106EFBE3A5BB6" modified="2012-11-28" version="1">MVLLIALAIPLVGSSSAQSSNSSMASNVTDPIGNNNVTADDLADNNTKTTTATNDLDDEIGTAGDDNLQVVNDTETSINDDVANIMINEVELNPPGSDLDGEWIELYNPVDADTNLTNFEIRTSFKSATIQLPPEAVIEANGTYLIELDGQILSNTAESLVLANSSGEIIDRTPSLVDRSDDERTWQRVPDGGDEWQFTAGTRGQLNDPGEQADATRSATSSSTAQCQGTAGCAEGMAIRIVDGDTLYVRVNSTIHKVDLALVSAPSRMDDGFIESTSFTRSLCLGSHVLIDQDDKLLTSDSSIIAVVYCESANLNSELLNNNYAALDAGQCQTSEFASQRWAREYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF7</accession>
    <name>K0IIF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L10e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl10e</name>
        <name evidence="5" type="ordered locus">Ngar_c18610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18610"/>
    <dbReference type="EnsemblBacteria" id="AFU58793">
        <property type="protein sequence ID" value="AFU58793"/>
        <property type="gene ID" value="Ngar_c18610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1844"/>
    <dbReference type="HOGENOM" id="CLU_084051_0_2_2"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_L10e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="4">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="161" mass="17733" checksum="2AE2AD962BB2DB35" modified="2012-11-28" version="1">MPYVRREYIAGKPQIKIARFSSGQAGNNYDYKLELLATEKIQIRHNALEAARLAANKRMATAGETSFFSMLRVYPHVILRENKMIATAGADRLQEGMRRAFGKATGLAARVMPGQVLFEAYVTAANLNLAKEGFKVASSKLGCPTTIRITPLKEQAVVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL4</accession>
    <name>K0IIL4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rps28e</name>
        <name evidence="4" type="ordered locus">Ngar_c28300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28300"/>
    <dbReference type="EnsemblBacteria" id="AFU59750">
        <property type="protein sequence ID" value="AFU59750"/>
        <property type="gene ID" value="Ngar_c28300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2795"/>
    <dbReference type="HOGENOM" id="CLU_178987_2_1_2"/>
    <dbReference type="OMA" id="MHGEASQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_S28e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7984" checksum="601DCD818B792432" modified="2012-11-28" version="1">MSKAAEEKVVPAEVIQIVGRTGIAGEVIQVRVKVLEGKDRGRILTRNVKGSVRMNDVLMLRETEREARKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ7</accession>
    <name>K0IIQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57987">
        <property type="protein sequence ID" value="AFU57987"/>
        <property type="gene ID" value="Ngar_c10450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10450"/>
    <dbReference type="HOGENOM" id="CLU_2177957_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1043-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="13137" checksum="C0D48F83674DFBB0" modified="2012-11-28" version="1">MLLRNYKFRLYPTVFQEKQLVEALDGCRWVYNYFLDKNLSLEDMQFALTELKGEERFLRNYHSKMLQMVVHKTYSANKVLKALKQNGHRVGRLHYLTDEGYNSFTYNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX5</accession>
    <name>K0IIX5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">albA</name>
        <name evidence="10" type="ordered locus">Ngar_c21120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21120"/>
    <dbReference type="EnsemblBacteria" id="AFU59043">
        <property type="protein sequence ID" value="AFU59043"/>
        <property type="gene ID" value="Ngar_c21120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2094"/>
    <dbReference type="HOGENOM" id="CLU_110989_1_1_2"/>
    <dbReference type="OMA" id="QFNEGAK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="9">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="11676" checksum="22390B4B7ED90EDD" modified="2012-11-28" version="1">MSEPQPSQEQTSQQKEGPHDTIYIGKKPLMTYVTSTLIQLANQPTVTIKARGLSIGRAVDVSQITLKRMESAGYKIGDVRIGSETVQSEDGRTRNVSTIEIEIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ23</accession>
    <name>K0IJ23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60010">
        <property type="protein sequence ID" value="AFU60010"/>
        <property type="gene ID" value="Ngar_c30940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30940"/>
    <dbReference type="HOGENOM" id="CLU_2165141_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3094-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12441" checksum="6CD04CCED297E069" modified="2012-11-28" version="1">MIYYAGNAVQGMQQPSDGIDVLPPEKIAFIAYNVGMFESVQKFGALITSGKITGGMDPAKVAELLENTPAFYDSEMIAQLVNGMLAQSSGMTVGRVTAAQVDNVIRQLKAAGVRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ27</accession>
    <name>K0IJ27_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">serB</name>
        <name evidence="11" type="ordered locus">Ngar_c21830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21830"/>
    <dbReference type="EnsemblBacteria" id="AFU59113">
        <property type="protein sequence ID" value="AFU59113"/>
        <property type="gene ID" value="Ngar_c21830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21830"/>
    <dbReference type="HOGENOM" id="CLU_036368_4_3_2"/>
    <dbReference type="OMA" id="DYAVANQ"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU59113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="25272" checksum="DCCEA34CE2CB776C" modified="2012-11-28" version="1">MLKYNRMLIIFDVEGVLLNAEYLPVLAQVMGPKKEKEIWDITNAGIRGEINWEEGLKRRVHALRGIKYEDAKRLAEGLPLMPGAKELCSALKKAGWKMIAVSGGFTIITDRLKTDLGIDKIFSNELVFKDGKLDDVIMHVTSDKAAAVRGTIKEWGIRKEDIVVVVDGANDLKLFALAGFTVGFCPVDVVREKANETIDKRDLGLLLHLLKKNFGEAVLINAASRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ93</accession>
    <name>K0IJ93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58312">
        <property type="protein sequence ID" value="AFU58312"/>
        <property type="gene ID" value="Ngar_c13750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13750"/>
    <dbReference type="HOGENOM" id="CLU_2165351_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1373-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12093" checksum="73333E490765F205" modified="2012-11-28" version="1">MQDKNRIPRWLVENDPSWEKSIDSDLGMLKWTKKGTGIQATCYPTSMFCEIVGQTDQAGLSDIVSSMRASRQAEIASGASDIVKYLSSRYLNPGINGPRLDLKKIHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF9</accession>
    <name>K0IJF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60160">
        <property type="protein sequence ID" value="AFU60160"/>
        <property type="gene ID" value="Ngar_c32440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32440"/>
    <dbReference type="HOGENOM" id="CLU_142273_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3244-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005560">
        <property type="entry name" value="DUF326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03860">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6063" checksum="29841CC9EFD5EFDF" modified="2012-11-28" version="1">MSMDSQFAKQFCNLCANICDACAQECDRHNVDHCKRCAQACRSCAEECRRMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI7</accession>
    <name>K0IJI7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15070"/>
    <dbReference type="EnsemblBacteria" id="AFU58442">
        <property type="protein sequence ID" value="AFU58442"/>
        <property type="gene ID" value="Ngar_c15070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15070"/>
    <dbReference type="HOGENOM" id="CLU_1821074_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1505-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="16241" checksum="4FAF007CE3DAE062" modified="2012-11-28" version="1">MFAIPTLTHTLRPALIVIDVQNGFVSKGGSYDRLRMDTSNYRSAVRKMQELVNLCREIGIPIFYTEAVREPSGIDLLTRVHRILPKSREKRIRKVPICVRGTWDAQVIDELKPTDDDHIIIKKEILPSKIRKQMYGSRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN0</accession>
    <name>K0IJN0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cache domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c24960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24960"/>
    <dbReference type="EnsemblBacteria" id="AFU59418">
        <property type="protein sequence ID" value="AFU59418"/>
        <property type="gene ID" value="Ngar_c24960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24960"/>
    <dbReference type="HOGENOM" id="CLU_784405_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2494-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cache" evidence="7">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="353" mass="39099" checksum="C2CF9A1F533357FC" modified="2012-11-28" version="1">MESYHLANLVESNVDLIDSNLEILAEAPSILNNDLEAAKIVINNRQAATSEITDRYVWLDREGKTVWSSGFVSEEEYDQYRGTDVSFRPYFTFPRDTGLPYYSATIESPDGVPRLFLAHPVLRSEAFEGVVFSAITLQNLGKILESSTSPELDSILILADTNGLIAYSSNSASTGSIIDIGAISPSSSSFDDGNRQLFDRMLQESHEDRRGSYDFVDFEGMSTTVAYAPVEARGERFLTLYVVVPHQVLAQISPLLQQHNYFVSAIILAIGSAAVGIAIVILSLNDLCRSQTEELTHANESLVKANEKLGTHDKMQREFINIAAHELRTPIQPRWPSLNCWATSLQTARTGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJP5</accession>
    <name>K0IJP5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo4</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpb4</name>
        <name evidence="3" type="synonym">rpo4</name>
        <name evidence="3" type="synonym">rpoF</name>
        <name evidence="4" type="ordered locus">Ngar_c25200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25200"/>
    <dbReference type="EnsemblBacteria" id="AFU59443">
        <property type="protein sequence ID" value="AFU59443"/>
        <property type="gene ID" value="Ngar_c25200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25200"/>
    <dbReference type="HOGENOM" id="CLU_2191149_0_0_2"/>
    <dbReference type="OMA" id="DQIQRWT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00864">
        <property type="entry name" value="RNApol_arch_Rpo4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010924">
        <property type="entry name" value="Rpo4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39646">
        <property type="entry name" value="PTHR39646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005053">
        <property type="entry name" value="RNA_pol_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12740" checksum="31302338A2E523BA" modified="2012-11-28" version="1">MTEIIKKEIVTLPHVKEILESVKPDDMDQIQRWTADYVTKFAKADSKKAQKMVRQLVEQCDLTEEEAVEVVNIMPVSLEELRAFTFGWKKLILTETLEKMLTILKEGTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJU3</accession>
    <name>K0IJU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59493">
        <property type="protein sequence ID" value="AFU59493"/>
        <property type="gene ID" value="Ngar_c25710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25710"/>
    <dbReference type="HOGENOM" id="CLU_3075480_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2570-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6202" checksum="90C39D3B31FF1330" modified="2012-11-28" version="1">MYFNSRSFRLAARSLSPIKKRSHVAVWKWVQKYADCADRFMTDIDGQSEQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJU9</accession>
    <name>K0IJU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59498">
        <property type="protein sequence ID" value="AFU59498"/>
        <property type="gene ID" value="Ngar_c25770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25770"/>
    <dbReference type="HOGENOM" id="CLU_161196_3_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2576-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="9907" checksum="B98022CF538AE7D4" modified="2012-11-28" version="1">MTTATIAARTEETITKRTPAVAKIVELVGVSNIGWEDAARVALDEAKKTIHNIHGIKIKDMTAEIDPNTGRITRYKACVKLSFGVIEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ0</accession>
    <name>K0IJZ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59543">
        <property type="protein sequence ID" value="AFU59543"/>
        <property type="gene ID" value="Ngar_c26210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26210"/>
    <dbReference type="HOGENOM" id="CLU_2490571_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2621-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9632" checksum="E8C60ED93556CE17" modified="2012-11-28" version="1">MASEVIATDRQYPKLSKAASGYIEIDHFKNADLHTGYFCYNCIYFIKDNHCAIVEDGGPDVNGRESGIIAPYGLCTLWDPNEKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG5</accession>
    <name>K0IKG5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c28280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28280"/>
    <dbReference type="EnsemblBacteria" id="AFU59748">
        <property type="protein sequence ID" value="AFU59748"/>
        <property type="gene ID" value="Ngar_c28280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28280"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2793"/>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_2"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2828-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="14814" checksum="84902D3E02B3F35D" modified="2012-11-28" version="1">MAVEQTLIVVKPDGFKRQLTGKILARFEEKGFQIKNLKSYNFTKEKAQEFYSVHKDKPFFGELVSFISSGTVVACILEGNNAVNTVRLMIGATKSFEAAPGTIRGDFGLGFTDNIIHASDSPESFIKESRVIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI9</accession>
    <name>K0IKI9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59793">
        <property type="protein sequence ID" value="AFU59793"/>
        <property type="gene ID" value="Ngar_c28740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28740"/>
    <dbReference type="HOGENOM" id="CLU_2433967_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2874-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10233" checksum="F62857C96664159C" modified="2012-11-28" version="1">MDEIQMKIATRDKIDMASIVDSALGVLGESNKRNLYHYLEKNYNIRIKPGEPIVPIKQLEQAFADLLGQGGAEVILDMINRQYQKIRVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKN2</accession>
    <name>K0IKN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC2</name>
        <name evidence="1" type="ordered locus">Ngar_c29450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29450"/>
    <dbReference type="EnsemblBacteria" id="AFU59863">
        <property type="protein sequence ID" value="AFU59863"/>
        <property type="gene ID" value="Ngar_c29450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29450"/>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_2"/>
    <dbReference type="OMA" id="QDPIKYV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="23928" checksum="DF59C001C9275560" modified="2012-11-28" version="1">MLSGGLDSATCLYWAKRKFSDVSAITFNYFGRLEQEKRAAVRLAKGAGVTELIQIDLPFVKEASDFYNGRLKKQDPDALWSSYVPARNLIFYSIAAHYAEYLGAKRMIGGHNLHDVKFFKDASIDYIEKLNALFKEGCLLCNGRAYKILLPLSEMTRKEIIKLAIKLKVPIEQTWSCHREGSVHCGRCYACKQRLDAFSSLGLKDPAFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKY5</accession>
    <name>K0IKY5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c31420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31420"/>
    <dbReference type="EnsemblBacteria" id="AFU60058">
        <property type="protein sequence ID" value="AFU60058"/>
        <property type="gene ID" value="Ngar_c31420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3120"/>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_2"/>
    <dbReference type="OMA" id="EFGHALY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3142-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="500" mass="58046" checksum="F010DA673E407021" modified="2012-11-28" version="1">MKSNNPVINQILDAYKPVWSINHATSLMGWDFETYMPRKGTEERGVADSQLHLLHKQLLLSKDFVDLVELAKKQQDGLNDVEKGIVRVLDRDITRQLKIPKELTEAESLERIRGNMVWRQAREKSDFKMYEPYLKKMIEIKKQVADKIGYEKHPYDVLLDTFEEELTVDDLDKVFGVLTPQIQKILKKLVDSGSPFCKESNLGKSKYDVQKVDELNRELLNLLQYDMERFRMDVSTHPFTEAMGLNDVRITTRYEGTDFKRSISSTIHEAGHALYHLQCDQSFSVTPVEGGSSLGLHESQSRFWENIVGRSRPFVQLIAPLIRKQVSFANQATDGDLYLYFNNVKPDYIRVDADEVTYNLHIAIRYEIEKKIFGDELNISEIPGFWNDRMEQLLGVRPTEDSQGVLQDTHWSSGLFGYFPTYTLGNLVSAIIAAKLRKDLKNYEENIRKGDFEPIKEWLRLKIHQHGSVYAPKMLLKNTFNEEYNPDYFVTYLETKYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL72</accession>
    <name>K0IL72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32780"/>
    <dbReference type="EnsemblBacteria" id="AFU60193">
        <property type="protein sequence ID" value="AFU60193"/>
        <property type="gene ID" value="Ngar_c32780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32780"/>
    <dbReference type="HOGENOM" id="CLU_020336_13_9_2"/>
    <dbReference type="OMA" id="HCIHHDA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3278-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="298" mass="32567" checksum="D13C2CB9918DE5E8" modified="2012-11-28" version="1">MCGTRKCGAVHLKQAFAKAGGLNIRYLEGGSDPADSSRKKRHHVLFIHGLGSSADRWLDIPDALALLDLHTVALDLPGFGMSDKPEDIDYTIDRFVEVVADFMGKAGMGEEGPVSFVGHSLGGYVAAQLAARHRNLIDRLVLIDTSGMLHGPTPLLQQYLEAAMNPSKESVRAVFEQLVADPIRIPDILVNGFIYRINQPGAKHAFKSAFDNSVYNQIGVDALKQIGDSKVPTLIIWGMQDRLIPLEYSRVFQESISGSSVVIVEDAGHAPFAEKPAIVCELLHRFLIIDTQEKKAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB2</accession>
    <name>K0ILB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60293">
        <property type="protein sequence ID" value="AFU60293"/>
        <property type="gene ID" value="Ngar_c33780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33780"/>
    <dbReference type="HOGENOM" id="CLU_2857220_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3379-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7370" checksum="C0711138033421DD" modified="2012-11-28" version="1">MLLSFLILAERLLKMAFAASLRPAEIMQHRHQDVLERPATSYMQRHFVTLQENASVASAIEQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD7</accession>
    <name>K0ILD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60343">
        <property type="protein sequence ID" value="AFU60343"/>
        <property type="gene ID" value="Ngar_c34280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34280"/>
    <dbReference type="HOGENOM" id="CLU_175266_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3429-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="11471" checksum="48B952C0B41DA28D" modified="2012-11-28" version="1">MDSTLRPVLKRQLLVIGASLGAGLVFAYFFGFLIGLAVNIAVMIGIIFYIRRKQLGALRSLGFGNETAGGGYGGGGGFGGKLKYVCLSCGAEVKGARCGRCGSNMKKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL9</accession>
    <name>K0ILL9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59552">
        <property type="protein sequence ID" value="AFU59552"/>
        <property type="gene ID" value="Ngar_c26300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26300"/>
    <dbReference type="HOGENOM" id="CLU_2021399_0_0_2"/>
    <dbReference type="OMA" id="MQYFQAV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2630-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12997" checksum="7B836EDD172AB361" modified="2012-11-28" version="1">MLILAVAKFAAGLQYHKAAHIGQERARKAQMKLFDYTGFAMLTYTIKQGKAGFEPVGEEDLAGKMTRENEAMLFICDKDGYAKAQSRPMPIEKGEEIFKKMLADGMPEFAGEIKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT4</accession>
    <name>K0ILT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)-dependent malic enzyme</fullName>
            <ecNumber evidence="7">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ytsJ</name>
        <name evidence="7" type="ordered locus">Ngar_c03710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03710"/>
    <dbReference type="EnsemblBacteria" id="AFU57319">
        <property type="protein sequence ID" value="AFU57319"/>
        <property type="gene ID" value="Ngar_c03710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.358"/>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_2"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="188"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="417" mass="45669" checksum="69521D293A3F2F02" modified="2012-11-28" version="1">MKQTESTQQVQKMESLQKRRKKPRGKPKATLGQQALELHRRVRGKIEVRSKVSARSPHEISIAYTPGVAEVCLEIAADRQKAYEYTSKWNNVAIVTDGTRTLGLGSLGPEAALPVMEGKAVLYKQFGNVDAFPICLQTTNADEIVRTVKNIAPVFGGINIEDIETPKVLEIVDRLTEELDIPVFHDDQHGTAVVTLAALLNALRLTKRKPEDTSVLVAGAGSAGYGIVKILYAIGIRDMVVIDSHGVISKARAPETMNRYKYELALITNHKEGVTTLADAVRGRDVFIGVSGVKKLLTAEMVRSMSKDPIIFPLTNPDPEIHPKEAFDAGAKVIATGSYKFENRANNALVFPFTMRAILDNRIRKISQQLLVNVACALADLIPKDRLSPFNIVPDVTDSRIQEVVNKAVRSATATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM26</accession>
    <name>K0IM26_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ileS</name>
        <name evidence="11" type="ordered locus">Ngar_c05760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05760"/>
    <dbReference type="EnsemblBacteria" id="AFU57519">
        <property type="protein sequence ID" value="AFU57519"/>
        <property type="gene ID" value="Ngar_c05760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.550"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_2"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="692"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1071" mass="122280" checksum="05C48493153E9331" modified="2012-11-28" version="1">MEFSTKFDAKAIENEVRNYLDNLDLRAHLENELAGKELVGYIEGPPTMNGEPHAGHLRGRIIKDLWYRFNTLQKKKVIFRAGWDTQGLPVELQAEKELGLTGSKAENISKVGVEKIVETCKKIIHFYNEKWVAVDKLLGISFNYEKAYWTFRDSYIEREWQYMRKAWESGVLREWFRVVAYCPSCQTSLSNAEVNQGYETVEDPSFYYKVKLADEDAYMIVWTTMPFTIVTDEMVGANPKADYNYVRANGERWVVGADRMQDLMRELRIEDYAVEKTVKGSELDGKHYIHPLLHMIPGLAELASNGSIHFVVAEDFVDTATGSGLVHLSPANGEEDFEVAAKRNVPIFVPIDDRVIFTEKAGSFKDLFVRDADMKVVQAMKEAGASVKLGKIKHQYPTCWRSHHKVVWLARREYFYIIEKLGDKPLQAAQNVEYFFEPPKNRFVEIIREQHPWCISRERVWGTPLPVWSCAKCGHKDALFSRAEIVKNAIELPDGPNFELHRPWIDRIKIKCEKCGAAMQREPFVLDTWHNSGAAPYASLTDEEYHDLIPATFLTEGIDQTRGWAYTLLMENVIMNQAGVAPFQSFLFQGHVLDEKGNKMSKSLGNVIEARTLLSDNPVDLVRLYFMWKSSPIESLNFSLDEMRTRSYQILSTLHNLHVYFKQNSEFDKFDQGKHVLQWVADNNLLGQTEVWLLSKLQGLIAEVTDSFARCRFHEGAKAIDEFIINHLSQTYIPLTRNVIWDDSAENLDRRLAVYSVLGHVLMQIDIMLHPLSPFITEYLYLTCFFGKKKSVLLESWPRRDEKLVNAKIESAFDRIKEIVSLANAARNLAGLKRRWPIREVIICGQGLQSLDIEGVSDALKSQLNAGQYRLVEISTGSQLEKVAGLLDSKMPISVSVELVRKNVAPRVKADIGKVVQAFENIDKLRLLGSLRSGNYSLTYDDGKTVELSPSDVEVAYKAAEGYSSSERGDLVVFISTTRDKDLMVKGLIRDLARQLQQLRKERQYNPTDILDAAYVAGLEAEEIAALSAMKDELTYLVRVKNVSLSKEPLDNKVNYKTVEIDGREFRISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM34</accession>
    <name>K0IM34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57529">
        <property type="protein sequence ID" value="AFU57529"/>
        <property type="gene ID" value="Ngar_c05860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05860"/>
    <dbReference type="HOGENOM" id="CLU_3075468_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-584-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5872" checksum="BF1468ADBE5E96DC" modified="2012-11-28" version="1">MIHHDVLVEIALGKMYNSEAVKMLTYITTPSQERTIPSSTSMLAYIEVIVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM67</accession>
    <name>K0IM67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06610"/>
    <dbReference type="EnsemblBacteria" id="AFU57604">
        <property type="protein sequence ID" value="AFU57604"/>
        <property type="gene ID" value="Ngar_c06610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06610"/>
    <dbReference type="HOGENOM" id="CLU_082323_0_0_2"/>
    <dbReference type="OMA" id="PSAIAYW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-659-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiEi_1" evidence="1">
        <location>
            <begin position="89"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="283" mass="32371" checksum="4C3372D63DA6D791" modified="2012-11-28" version="1">MESMSASKMTRNVRQGLSRKESLLLSSLSEKDKKIFALRDVVDELSCSYAYAKNLAKTLARKKWVINLSRGTYLIVPLSAGVEAKYTEHEFVVGSHIVSPYYIAYWSALNFYNFTEQTPYTVFIATTKRAKSRTILDVKYSFITLNKKKFFGFSGTAVGTDRVNISDKEKTIADALDHPEYCGGMTEVAKCLWNARDSVSYEKILSYAERMGNLTIIKRFGYLLELLNIVMKEDVVVRMKESISPGMSILDPTMSHSGRYNTRWNLLVNVSKDSLVRWREEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB7</accession>
    <name>K0IMB7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57739">
        <property type="protein sequence ID" value="AFU57739"/>
        <property type="gene ID" value="Ngar_c07970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07970"/>
    <dbReference type="HOGENOM" id="CLU_136580_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-795-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17417" checksum="DBE3DD71E32EF587" modified="2012-11-28" version="1">MVKINPSVTLELSDGQKITINIDEAKQLIKGLGKFVQEDNGRAKNVTLQTSTKRRKKGRKSARKSHKRSFSGMSDAKQKSILDHVNKRLSSNPQTLSHLLKGISYVPNHLPMIRKMVENQKHVSKRLIGKRMFYFLAAAENKRVGRPSKVTAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF1</accession>
    <name>K0IMF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57854">
        <property type="protein sequence ID" value="AFU57854"/>
        <property type="gene ID" value="Ngar_c09120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09120"/>
    <dbReference type="HOGENOM" id="CLU_3163250_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-910-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="47" mass="5748" checksum="2FD4E5139E226C14" modified="2012-11-28" version="1">MGVNRYNLQAYMKSFQFVHNLRDKTREERFVQILCYNQLKHLSIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG4</accession>
    <name>K0IMG4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60257">
        <property type="protein sequence ID" value="AFU60257"/>
        <property type="gene ID" value="Ngar_c33420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3331"/>
    <dbReference type="HOGENOM" id="CLU_2748329_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3342-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8085" checksum="AD352C18188AE6BE" modified="2012-11-28" version="1">MTFSTREELKNHSVSVHSAAEARARGIIIRMPERRTVIVAVAITGVFAAGLVLQYYLRNRRGRERRRMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH6</accession>
    <name>K0IMH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K+ transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c33770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60292">
        <property type="protein sequence ID" value="AFU60292"/>
        <property type="gene ID" value="Ngar_c33770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33770"/>
    <dbReference type="HOGENOM" id="CLU_1691594_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3378-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="16693" checksum="1DABE244EC2A7201" modified="2012-11-28" version="1">MTRNGLAVGMVTSGDVVEKVVLKGEDSGRVPRSIMSFLLVTISSTGTVKQALQLMRLNRIKRVPMTDSSTGIIGVMTQRSLADAVNKSVLERTLERARSTFRMRYKPVLGNLGILLQFSAVLLVVPALVGTALGEAGSITGVYLKWRGSRLPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI3</accession>
    <name>K0IMI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative universal stress protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60312">
        <property type="protein sequence ID" value="AFU60312"/>
        <property type="gene ID" value="Ngar_c33970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33970"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_2"/>
    <dbReference type="OMA" id="CNDESIE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3398-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="17584" checksum="A3E2FFCF794AE72C" modified="2012-11-28" version="1">MVFKKILVPYDESAYSKRALEIAAQYADEVKNTQIIVLHVVPVLPVPAMYLGTARSTKTGETTTMAAFLKEVHQEMKIEMAKRLQDLVKKYRLQHPIATKIVTGSPAEKILEVAKEETVDLIVMGRAGATGIGRIVKAMGSVSRVVSEKSSCPVMLVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI7</accession>
    <name>K0IMI7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60322">
        <property type="protein sequence ID" value="AFU60322"/>
        <property type="gene ID" value="Ngar_c34070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3404"/>
    <dbReference type="HOGENOM" id="CLU_088139_0_0_2"/>
    <dbReference type="OMA" id="CGANEIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3408-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="30687" checksum="95805851B05829B0" modified="2012-11-28" version="1">MFSFHRKNMHNKISKHSSIFLAIIASAIIVVLGSAMNVAYAQTLTIETDKDSYASGDEITISGQLTAPTINQPILIRVFDPDGNFVRSEILDAAADGSYSYTFTSGGPLMAKSGTYRVQATYAGTVNQETTFEFEAAEGGGWRTIQAEIGGQNHPIEYMITGSGNRLVSITGNTETATLVATLSTASDGTLSLRFNEEIFDADDFFVAFADGIPTNYELPAGPGATNELHIDFEWGTEEVEIVGDRIIPEFGAAIAAIVLAVAIVGIIVATARYGKFNFVRKEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ5</accession>
    <name>K0IMJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57944">
        <property type="protein sequence ID" value="AFU57944"/>
        <property type="gene ID" value="Ngar_c10020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10020"/>
    <dbReference type="HOGENOM" id="CLU_126931_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1000-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="19927" checksum="43C411C52A82B468" modified="2012-11-28" version="1">MTQTADNEISESEDKSIESATTADEMNKGEETKTEVEQGSMQAGVLGVREEQQQEATTEAAAAATTTTTTMSPEHTLLLQVLRRAKRQQDLITQIQKSLKTLASIEKSIGKATEQVRLLQSAIRDSQRQITQIQHQVAALEKAQAKGFQKIAKQKRVAGGGGMKRASSATTKRKKRGMSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN2</accession>
    <name>K0IMN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11020"/>
    <dbReference type="EnsemblBacteria" id="AFU58044">
        <property type="protein sequence ID" value="AFU58044"/>
        <property type="gene ID" value="Ngar_c11020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11020"/>
    <dbReference type="HOGENOM" id="CLU_788981_0_0_2"/>
    <dbReference type="OMA" id="IFASIMP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1100-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="351" mass="37561" checksum="9B4004B34AA9FFF2" modified="2012-11-28" version="1">MRIIAMLAVLAILGFTPTAFAQLSEQELDFYPAFPTDKNEVTAIISLTTGTPCEKVESQGHELDGNNLSINVRIVPPPPDTSCAQVVTQHVLEQDIGRLEAGTYAVQLYVDGTPRASATLHVSADDVAILSTGKYTDDQGDINLVGEVQNVADHPVKLVQIGVLFFEEDDGALVKEQKKIYTMMALIMPNRTSGFSLGLGSDLQDNAYSVNITSFSVEDKPVERGLMLVVEPALGSDGYGVVGGHVLNRADHDATQVKVVCAIYDDDGNVVDSIFGYTNPDTIPPRQTAPFSILTHSKISQGFTTSCNAESIELAIEEVQVVPEFSAIDAVVVAGASLAAVLAVNRLRNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMS1</accession>
    <name>K0IMS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADH dehydrogenase/NAD(P)H nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11990"/>
    <dbReference type="EnsemblBacteria" id="AFU58139">
        <property type="protein sequence ID" value="AFU58139"/>
        <property type="gene ID" value="Ngar_c11990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11990"/>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OMA" id="HPYAKML"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1197-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="19457" checksum="437622D9EE81337F" modified="2012-11-28" version="1">MKFDSVVRKRKMIRKYLPKQVSDQIINKLIENASRAPSAGHTQVQEFIVIRDPAVKKKLRQASLNQAHVEDAPVLIVVCSNTSRSVGRYGQRGREFYSVIDGAFASMLILLTAVNEGIGAGFVAAFEDDKVSEILGIPEYVRPVGIIALGYPDEKPAKMERIQKERLVHHERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT9</accession>
    <name>K0IMT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58204">
        <property type="protein sequence ID" value="AFU58204"/>
        <property type="gene ID" value="Ngar_c12640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12640"/>
    <dbReference type="HOGENOM" id="CLU_2285133_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1262-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11662" checksum="54C042769EF45BF2" modified="2012-11-28" version="1">MLIVDVRDLDKMERTIRWIEIALIIGKNLVFIIAAFVGISFMIAIYNSLVGNIVGSIISLAFGAAGLVFFAQVRQTRRRHYRRRVKYQETRQQKYREVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY2</accession>
    <name>K0IMY2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14840"/>
    <dbReference type="EnsemblBacteria" id="AFU58419">
        <property type="protein sequence ID" value="AFU58419"/>
        <property type="gene ID" value="Ngar_c14840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14840"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1448"/>
    <dbReference type="HOGENOM" id="CLU_670177_0_0_2"/>
    <dbReference type="OMA" id="WIFSINA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1482-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="412" mass="44394" checksum="3BBF70F3AE57629F" modified="2012-11-28" version="1">MAESDVRVSPVSKPFIVTAVILVFAGSIIGSLWMMSLLGLDLAFARGAFSLHKSFQVDGFLTLIIMGVGYMIVPRFRNVQVPSIRLTYFSFLLVAFSVAASIVSAIGSDLSVPGAFARAAGVSIFAAITLWTLRIHPKLLRIADYFISLSVITLLAINGIHLAGYSAGNPLSGVQLLLLFPVLMIFGVEYKTLPSFIGFIRPRKRLSAVSFGLAAISVVLGLSSALHGDPLLAIAFNVALLGCAAAFAGAVYIFGGFDNSEIMRLIHGEKKARYMYTIQHSRLAFLFLYAGIAVATAFNVSSSYMLYDLAIHYTAIGFIGLTIALYLPLMLPPITGRMIRFTKFNSVPVLLVILALAVRTAGDVAITTQVTSKEVSYLLMTSGWLVVAALSTFVAMIHRSMKEEDNVIDGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN08</accession>
    <name>K0IN08_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priS</name>
        <name evidence="13" type="ordered locus">Ngar_c16160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16160"/>
    <dbReference type="EnsemblBacteria" id="AFU58549">
        <property type="protein sequence ID" value="AFU58549"/>
        <property type="gene ID" value="Ngar_c16160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16160"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1584"/>
    <dbReference type="HOGENOM" id="CLU_056123_0_0_2"/>
    <dbReference type="OMA" id="GYHVHVR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 10 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU58549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="391" mass="43506" checksum="78FAB73827AAC68B" modified="2012-11-28" version="1">MTESAVVKTINAVKSAFRGYYFKPDMVEAPDKMEQREFGYMQFGQPGMVRHLSFKSMKELTATIMKEVPSDIYCSNAYYRFPTYPMQEKQWLGADLIFDIDGKDLHLPCVPSHSYPICTNCGHASAPVPDEKRKEEHYSCPACGGKKADDISIPCAKCIEGSKREVKRLVEFLTGDLGMQRSDIHIYFSGNNGFHIHVSDEAYIPLDPQARSDLVGYLSGSGLMAESIGVRKGNAENLFFIKFPKSGLAYGWRGRVANKLKIDGSSMIKLKHIVEQKGGYAAFKADLDRMTRDIGVRIDPQVTTDVHRVFRMSGTLNSKSGLAKIKCGDNIDSFDPFVDACLLGDGKLSVKVKTQVKLKLKNKSFNISKESAELPAYAAIYLICKRLAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN44</accession>
    <name>K0IN44_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-cone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c17960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58729">
        <property type="protein sequence ID" value="AFU58729"/>
        <property type="gene ID" value="Ngar_c17960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17960"/>
    <dbReference type="HOGENOM" id="CLU_1574999_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1794-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="5">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="19170" checksum="CDE055485C1D15CE" modified="2012-11-28" version="1">MPYWYMARKKKAVKKRTTRKSKGAAKRKKRPRKKPAAVTIRRSSGRKEKFDLDRMAATTSRSGVPFLIARDIAKNVSKQIKSEAKEKSKKTVTAGRVRNMIAEELRGRNQQAAVSSYIGEMPENTQHDKANVDQYESPIGSADTDQHNAYRANRDSVMHDRSKRFASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN91</accession>
    <name>K0IN91_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58964">
        <property type="protein sequence ID" value="AFU58964"/>
        <property type="gene ID" value="Ngar_c20320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20320"/>
    <dbReference type="HOGENOM" id="CLU_1830650_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2030-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15303" checksum="63080D7C206980D7" modified="2012-11-28" version="1">MSDSTIPLDHDALSGLLSDPVMIRVVTVVNLASLSILELLEYGFTRKDVNRAMAKGVIEFDKPATLSAPETMSKSGVVQHVLETGDYYFGVLSSKVKLTKLGLYMLEIIEADTQSAIAEGSLDEPEQEARSQFSKLVSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB1</accession>
    <name>K0INB1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59064">
        <property type="protein sequence ID" value="AFU59064"/>
        <property type="gene ID" value="Ngar_c21330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21330"/>
    <dbReference type="HOGENOM" id="CLU_2379506_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2131-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10741" checksum="B3FFCE831A81A06D" modified="2012-11-28" version="1">MTPEEIALFFAGIIATWLFARLYYQKSSSEINRNFARVESQVIALDRKLSDVESAKTFKDARIGGHYDLMTRVAPDENNTRSNDIVPAIKNFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC6</accession>
    <name>K0INC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c22090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22090"/>
    <dbReference type="EnsemblBacteria" id="AFU59139">
        <property type="protein sequence ID" value="AFU59139"/>
        <property type="gene ID" value="Ngar_c22090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22090"/>
    <dbReference type="HOGENOM" id="CLU_466634_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2207-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="584" mass="65934" checksum="FC5AABE280AC55BE" modified="2012-11-28" version="1">MSALPNAGDRGAPDIIRSPTDAHQLYVDLVNSAGSEIMLLLPPPLPSSDRASMLHSIFQSLEDAAKRGVQVRVLTTASVKLLTANTNNVAVRYIHREGRAEMQEILIVDRKATLEYGIMRDGHDAVSIYSSSPSAAMPLVTMFDNLWDQAAAYEKFREADRMKDEYIQKQRELYDKLREADRLKDEFINIAAHELRTPIMPILGGLELIESKLGNNSSIKEELAIISRNAERLLKLSEDILQASRIETGRLRLYVEQANLNTLISEVIADVEQKYRQQLAKVPDIETADIHSLIMHIVGERVDKEARKPIILFEPGEPILMVECDRGKIGEVLFNIIDNAMKFIDEREGSIVVSTHLSGSNVIVSVKDNGRGIDPSIKDKMFQKFTTRSEKGSGLGLFIAKSIIEAHGGTIWAGNNSDGKGATFAFSLPVRFRRSEPPTPDQLPQITDNQRTINQLRRDALEKIGAMKTSLTEAREEALRKRNEALERYQKQVEESRNLIRARQQFINQQISYKRMRREVDSRIEKGLEGLQRLIDGLRENIIGDETIEKIELHPTLIDAIKYEAGKVTESEFFKSLRRQLATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING2</accession>
    <name>K0ING2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59319">
        <property type="protein sequence ID" value="AFU59319"/>
        <property type="gene ID" value="Ngar_c23940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23940"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2392-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10679" checksum="F9375A56306B9E97" modified="2012-11-28" version="1">MKYRSRADICTEILKIADRGTSKTKIMYGAYLSFTQLREYLKLLLDNGMLSFDEKTMQYRTTETGHNFIKMYERIDQMFDRKQQTGSEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH8</accession>
    <name>K0INH8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c24760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24760"/>
    <dbReference type="REBASE" id="55353">
        <property type="entry name" value="M.Nga92ORF24760P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59399">
        <property type="protein sequence ID" value="AFU59399"/>
        <property type="gene ID" value="Ngar_c24760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24760"/>
    <dbReference type="HOGENOM" id="CLU_024927_2_0_2"/>
    <dbReference type="OMA" id="DHEIGRE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2474-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="353" mass="40231" checksum="5B9DA324632EB00F" modified="2012-11-28" version="1">MDSESFKIIHGDAYETVRRLPGNKFRAIITSPPYYRHRHYGNNDHEIGREHTAEEYLDSLTKVFSACRDILADDGSLWIVIGDTRRRHEKLRIPHRLAERLVHAGYVFREDIIWYKKNNVSSSSQDNFSQAYEYVLFFSKNRRSYANLDAVRVQGNEAVEGRNKVPPPDMVQYAPENPNKSEITRIANIIHGASPSTPLSELPTTSEIARAYGYDPEKFCPTCYRKFKRHATRRRIGDHKHYPIFAVCNPHGKNPSNVWEIATKAHYGNEHFAIFPEELVDMIVRFATEKGDYVLDPFAGRGTTGIVATSLGRKFVGIDLYKENVEKASRNITKADCSNGANLIMGLAPNSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK4</accession>
    <name>K0INK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59529">
        <property type="protein sequence ID" value="AFU59529"/>
        <property type="gene ID" value="Ngar_c26070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26070"/>
    <dbReference type="HOGENOM" id="CLU_1682759_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2607-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="21421" checksum="3B1113BD70F4B03F" modified="2012-11-28" version="1">MHSAKDKHKVVNRHGKKPYCRMPIEFSRQAQQAFSPEFKARIMQAYALFPELQNKTIACGLLKRRGWVQGTAIGWANPPVFRLQPNVSVYTIAHELTHLVQGDGSGIPHGEVPCDIWTVDKLPAELLDQRPYYLLKNSRCDWKRHKLAIKDLCRQAIEIRKTQRMYIVWLRNQIKKLDSPYRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK7</accession>
    <name>K0INK7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26220"/>
    <dbReference type="EnsemblBacteria" id="AFU59544">
        <property type="protein sequence ID" value="AFU59544"/>
        <property type="gene ID" value="Ngar_c26220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26220"/>
    <dbReference type="HOGENOM" id="CLU_1840648_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2622-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15351" checksum="CF36F2C4C8EBD07F" modified="2012-11-28" version="1">MFLRKCRLSKNERDEAAALGIKVVNDTIKHIAGRRGGLPKELICTGGRRYSADVVFYKLGYHVQSKLAERLGCKLDERYVKVGSEQQMTMPSVYAAGDVDTDRHFVVLAAAAGARVAISIYEKLLKEAVKAKVEGHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT0</accession>
    <name>K0INT0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59909">
        <property type="protein sequence ID" value="AFU59909"/>
        <property type="gene ID" value="Ngar_c29910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29910"/>
    <dbReference type="HOGENOM" id="CLU_2447768_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2991-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9364" checksum="91AF2EDB0659BD92" modified="2012-11-28" version="1">MQLQFAIVLLVFGPTSEFIVHKMGSIKPIIIVTSVTATGFLFLLAFHGSWMAVAAGLAVLLTGLSLTNVGALNVTLLATPAEFTAYRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INT4</accession>
    <name>K0INT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59929">
        <property type="protein sequence ID" value="AFU59929"/>
        <property type="gene ID" value="Ngar_c30110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30110"/>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3011-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="180" mass="21138" checksum="BEDB4B90BA68DA41" modified="2012-11-28" version="1">MSEERRKTETIAFRLDTTLIEKLRKEASQKEISLNTMASQIFRQHVDWHSNAAKAGFITVRKGLILRLLEIATEEQLVKIAEYIAKKETKNFVLMLRNEYNITSALDVVETWIRIAGYPYRHDANYSKHSYTIQHEMGKKWSMYLAEQYRFLFEDFGLKKVKFDITDSVLSFSVDTDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU4</accession>
    <name>K0INU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PQQ dependent glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30630"/>
    <dbReference type="EnsemblBacteria" id="AFU59979">
        <property type="protein sequence ID" value="AFU59979"/>
        <property type="gene ID" value="Ngar_c30630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3035"/>
    <dbReference type="HOGENOM" id="CLU_012253_0_0_2"/>
    <dbReference type="OMA" id="LWAHEMG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3063-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008876">
        <property type="term" value="F:quinoprotein glucose dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="57"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="371" mass="40527" checksum="E176E5F7C4C5955E" modified="2012-11-28" version="1">MEKERRLVVVAVAAVVIAAVTTAFFAPSQTTLPIPEPRRNSGGNSTSSGVQVLAENLEVPWALDVAEDGRIFFTERAGRIRVIENGTLLEDPVAFINVEQNEESGLLGLALHPNFTENHLLYIYHTYSNGSSILNKVLMLTERDNQIIESKVIIDGIPAADRNDGGRIKFGPDGKLYIATGDARQPELAQDGRSLAGKILRLNPDGTIPEDNPFEGSPVYSYGHRNIQGLAWHPETGELYASEHGDQGNDEINIIRPGANYGWPIEDCNAERFEEPVVCFTPAIAPGGIVIPSSDRLGYQSDIVLAALKAQQLRLVELPLDSERNILTGYGRIRDVVEAPDGTLYVATSNRDGRAIPEQGDDKILRITNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP16</accession>
    <name>K0IP16_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60339">
        <property type="protein sequence ID" value="AFU60339"/>
        <property type="gene ID" value="Ngar_c34240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34240"/>
    <dbReference type="HOGENOM" id="CLU_194224_0_0_2"/>
    <dbReference type="OMA" id="CKEHYKE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3425-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7619" checksum="1B24B8F8E3E47590" modified="2012-11-28" version="1">MGRVDKGVNCSVAGCVNQAERSMSGTKASMAPDLGLGGSKRVYLCRDHYKEWKKLTKEDRDNERARWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8L7</accession>
    <name>K0I8L7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57626">
        <property type="protein sequence ID" value="AFU57626"/>
        <property type="gene ID" value="Ngar_c06830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06830"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-681-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15873" checksum="8F0886BDDF710C31" modified="2012-11-28" version="1">MVDEQYFASFCHQILNEHPSIRFVGLADRQGHLITTAYRKNLVPLMDSKDTEKYTFQTVIRASMREVFEDKIGKQRYAVGLYEKLIRATIPIAFSSNKNRKFYLLMSFDLDSDYGHIIERKILPIIKEHKEYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9H1</accession>
    <name>K0I9H1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BNR/Asp-box repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58001">
        <property type="protein sequence ID" value="AFU58001"/>
        <property type="gene ID" value="Ngar_c10590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10590"/>
    <dbReference type="HOGENOM" id="CLU_1493022_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1057-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="180" mass="19923" checksum="D33D4AB3E2A08D5D" modified="2012-11-28" version="1">MRPNNIIRILETVLSFLALMPMVAGFVPADGTTNSSSLLPQGNSTFLNDGKITNSSAITIEDDANMTITCCLPLLLAPIAASGNNVYVVWWDNKTENWEIFFARSTDNGRTFEQPLNLSNNTGRSENAQVVALDENVYVTWWDNTTGTREVFFRASEDNGKTFGHAIILESTRSMDFTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA67</accession>
    <name>K0IA67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">etfB</name>
        <name evidence="2" type="ordered locus">Ngar_c12660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12660"/>
    <dbReference type="EnsemblBacteria" id="AFU58206">
        <property type="protein sequence ID" value="AFU58206"/>
        <property type="gene ID" value="Ngar_c12660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12660"/>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_2"/>
    <dbReference type="OMA" id="KTPTVMN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="292" mass="31904" checksum="EF88D55EAB5FBC1A" modified="2012-11-28" version="1">MANLNVAVIVKLEPDFSEGNVSYNADGTLNRAETKSILGPHSAVASSAAFYAKVRYGASVAVATMGPPIADSALQQAQLLCDADELYLYSDRMFAGADTLATAEVLKTGISKLEGKMDIVFSGHRASDGETGQTGPQTAWKLGFTFLGNVIDYDVDMQNRIVRARRMISLQGFYDVVEEVEAPLPVFIAIDPSYKASFNTVSQRLAFEKYQKEAKERAQNYKQYLKVFNAQQLGVDPKLVGLPGSPTIVYKVERIPKAKASRRAEVVDGTNREQLAKVATRMYEVVGGMVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA86</accession>
    <name>K0IA86_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58236">
        <property type="protein sequence ID" value="AFU58236"/>
        <property type="gene ID" value="Ngar_c12980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12980"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1296-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8655" checksum="58EA6D57C6172C90" modified="2012-11-28" version="1">MLEIALDGAIKTKIMYKAYLSFPQLKEYLAVLEEKGLLEYVSTDNEYRTTDKGKHFLKMYKDVGQMIFPNSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAG0</accession>
    <name>K0IAG0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c13630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58301">
        <property type="protein sequence ID" value="AFU58301"/>
        <property type="gene ID" value="Ngar_c13630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13630"/>
    <dbReference type="HOGENOM" id="CLU_1623512_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1361-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="18409" checksum="5D6370F1C6886596" modified="2012-11-28" version="1">MSSKKKKLENDLIEWRRSQVLSMLATGLSQTEIADMLKVAVSTVNKDIKKIRLEAKAKQQDYIDNELPFQHKLAVASLDKVLEEAWQIFRTEKAVKARLAALEIIADSTMKKQAVLGDPAQIEKAIKLVNRLRKQISSTGQAQLEEGSGHQQQLEEEQEEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAK1</accession>
    <name>K0IAK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative copper amine oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14100"/>
    <dbReference type="EnsemblBacteria" id="AFU58346">
        <property type="protein sequence ID" value="AFU58346"/>
        <property type="gene ID" value="Ngar_c14100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14100"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1374"/>
    <dbReference type="HOGENOM" id="CLU_015706_0_0_2"/>
    <dbReference type="OMA" id="FQGAYVY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1408-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="758" mass="85027" checksum="194A134DD860B006" modified="2012-11-28" version="1">MAGVGITAAIGFVFALSSLGNTLIPPEVSSPEIFNNDDGGAGPTVFATATQALKKFSSVDELKSYLLSVEANRGELETAARSFFGGSSISRGDVVNPTVTDQGTGLESLQSSAPPAPSSADAPRLAVIESGDKDYSTTNVQVQGVDEPDFLKNDGKYVYILSGDRLTIVDAYPPENATIAVKIALDIQQGQYLQNMFLNNDTLVIFYQEYSRDFVIQQYDFAPQPISRPNTHALLLDVSDRENPQVLHNYKVSGNYNNARMIGDQVYLITTSDLYDYRNPILPLVSESSSTIVRPDIYYFDNPDLYYTFNTVTSIDITADEGENAVNSTTFLMNPASTLYASEDNIYIAYQKNHPYYYYQSHSKDRFFEALVPLLPQNVQQEIREIEGNSDLTPSEKWDRVSELLQDTYNHMPESEKRRLFEEIRQALADYDERIAKETQITVIHKIAIGPEGISYSSRGEVPGRLLNQFSMDEHGDRFRVATTSEFYSPYRGSTMYNNVYVLDEAMKIVGKLEEIARGESIYSSRFMDDRLYLVTFQRIDPFFVIDLSSDAPKVLGELKLPGYSNYLHPYDENHVISIGKETKENQYGGIETLGIKLVLFNVSDVNNPAVVDVYEIGSSGTDSEVLYDHKALLFDRSKNVLSIPVSIYPDYAGPRYTEDGRYIEPKVWRGFYVFGVNPEAGFMLKGIVEHLNDTGDYYYIYGTQGSRSFYIADVLYTVSLNNLIKMNDLQSLNKINQLEIGPSGSIIKSPQLEDDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBR2</accession>
    <name>K0IBR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57005">
        <property type="protein sequence ID" value="AFU57005"/>
        <property type="gene ID" value="Ngar_c00550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00550"/>
    <dbReference type="HOGENOM" id="CLU_2613749_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-55-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9404" checksum="23E55472B6C60C47" modified="2012-11-28" version="1">MEAYNKIVKNEFLAVENIPDREDGKARYAMFVNAYNNMDREHGGIIGGLTPQERWLQLQLLNTTPTRNRNRLKKSVTHVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC07</accession>
    <name>K0IC07_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58866">
        <property type="protein sequence ID" value="AFU58866"/>
        <property type="gene ID" value="Ngar_c19340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19340"/>
    <dbReference type="HOGENOM" id="CLU_1393620_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1932-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="20870" checksum="E7989F7C389904F3" modified="2012-11-28" version="1">MQNPSVETRRAFGFLFVCVSIVVGAASVMSEFAYINSLPLYYYAIIWLGSFGAVFGAGAAKFRKAAPAIRSRMRTSVKWPSGAKALNGICWAGPFAAIAAFPSFYQYLILLGIGLGNLSTYLLIKKYGNADNREQLIVAVISLAAIPAAVVIDSSLFAMHQDIAVMLSRILIAIAYAAGGAFALLGGGRKAGSSDLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC37</accession>
    <name>K0IC37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TrbE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19840"/>
    <dbReference type="EnsemblBacteria" id="AFU58916">
        <property type="protein sequence ID" value="AFU58916"/>
        <property type="gene ID" value="Ngar_c19840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19840"/>
    <dbReference type="HOGENOM" id="CLU_442559_0_0_2"/>
    <dbReference type="OMA" id="TEYRKLE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1982-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="248"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="420"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="555" mass="62465" checksum="3E3A45F434B2B166" modified="2012-11-28" version="1">MQFYRYFVESEENIDDRLSSFGLLYNRISEIPSYTTIIRKMSDRMILPEGKMVRTFTLYKLSSTLVEGFVSETYGIADEVSIVIVPIMQEQATAKMNKYAKFLSGMILADQQKRRTSPYELVQRYTMAHQTLELLTNGQTRLFKIMVNFVVGGKDRKDLNRNVKLLKNTLQARLLYIDSPRFVQGHLLAGNLGKRLVVDTTTAATLFPFVSADIVELPDGVFIGANKLTGAPVIYDVFMHDNYNISTLGTSGSGKSFSTKIIVSRMLQRNPDAALFVFDPENEYMKVGKVLEANVVEFDPHSDMGLDPLKIYSPIDASEIIASITSLPQDYHATLRTIANKADNIEALYNNSPEEMRGYLKDLVGDGTLAHVFRGKPVEFTNRMVFSMKDIESSIEKNLLSLLLFGKVWNMINDESHLPRAVQKVVVVDEAWLYLAIPAAARFLERTARLGRKRNVCFIINTQRAADVLGESDEKPGLGRSIIENSATKILLRQDELSADVVARAFGLSEREREHLVELESGNGFLIAQNVHVPIKFVASEEEEQIFTTKPSDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC65</accession>
    <name>K0IC65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58946">
        <property type="protein sequence ID" value="AFU58946"/>
        <property type="gene ID" value="Ngar_c20140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20140"/>
    <dbReference type="HOGENOM" id="CLU_149773_0_0_2"/>
    <dbReference type="OMA" id="NRPSEAK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2012-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="11194" checksum="3EC7BA30BE75C031" modified="2012-11-28" version="1">MIIGGTLGLSMFAVWSQAGMPGWGGGGMMSGGWGMMMSGGFMWAAVGTMAAISVGAGTVSILGGYSIYKRPESSGAWGVAILISGIVGLVGMSGFFIGPILGIIGGILALTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICL3</accession>
    <name>K0ICL3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04130"/>
    <dbReference type="EnsemblBacteria" id="AFU57360">
        <property type="protein sequence ID" value="AFU57360"/>
        <property type="gene ID" value="Ngar_c04130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04130"/>
    <dbReference type="HOGENOM" id="CLU_109676_0_1_2"/>
    <dbReference type="OMA" id="STVSWHL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-412-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="20496" checksum="064EAE16588CAFA9" modified="2012-11-28" version="1">MPFEDSTKDRVYSFIASNPGSYFREILRSLEIGTGNLQYAIELLEREGKITAIRVGAYKHFYPSDVDEEKKKILGILSQESPREILLFLSRKPGACQTEVAREIKCSSPTARWYLVRLESLGLIWSRKQGVEVKYYANTSIPELANLLKAYRPSIWSKYADRMADMLRTFDAEGDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICR6</accession>
    <name>K0ICR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57440">
        <property type="protein sequence ID" value="AFU57440"/>
        <property type="gene ID" value="Ngar_c04960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04960"/>
    <dbReference type="HOGENOM" id="CLU_159352_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-494-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="DUF5519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="DUF5519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="13847" checksum="3079861A58F68065" modified="2012-11-28" version="1">MMEESASEVAKRELLNWPGVTVHDHRFGGLEFRVNGREMGHIHGDELADLPLPKDISRKLIAQGKVSPHHFIPQSGWISYYINGTADIPGLIELFRMQYERMTSYGKKSKSAPATTPVSSAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICR8</accession>
    <name>K0ICR8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59161">
        <property type="protein sequence ID" value="AFU59161"/>
        <property type="gene ID" value="Ngar_c22310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22310"/>
    <dbReference type="HOGENOM" id="CLU_2646047_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2229-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8235" checksum="F36F405EF84420A2" modified="2012-11-28" version="1">MAEGGGKQRINGETITGIALVFLALLFIWAGTMNPVWASIMLADYIILAIGVGFIIVGVIAIRRTNRPHSEHASHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICS8</accession>
    <name>K0ICS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57455">
        <property type="protein sequence ID" value="AFU57455"/>
        <property type="gene ID" value="Ngar_c05120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05120"/>
    <dbReference type="HOGENOM" id="CLU_2597857_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-510-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8753" checksum="D52602C0D5870DFD" modified="2012-11-28" version="1">MAYSVVKVAADMDWKKWVEFYDGVIQPLVNAGARIKINIELTGSSETGIPKNTVDLVIKENLSQYGITARIEPKTSNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICW7</accession>
    <name>K0ICW7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">Ngar_c05670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05670"/>
    <dbReference type="EnsemblBacteria" id="AFU57510">
        <property type="protein sequence ID" value="AFU57510"/>
        <property type="gene ID" value="Ngar_c05670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.543"/>
    <dbReference type="HOGENOM" id="CLU_073198_1_0_2"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20861" checksum="07419B56960748AC" modified="2012-11-28" version="1">MHIPHFVHTKNLPSGTPDEINVVIEVPKGSSIKYELDAETGAVFVDRRLFTTMVYPCNYGFIPRTLEGDGDPVDVLVLGDYQVVPMSVIRATPVGVLLTEDEEGPDAKVIAAPIAKIDPSFAGVKDIGDVPRYILNQIEHFFEHYKELEDGKYVKVKGWKPQQVAKTKISEAIERFRAQEEKVVKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID31</accession>
    <name>K0ID31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57570">
        <property type="protein sequence ID" value="AFU57570"/>
        <property type="gene ID" value="Ngar_c06270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06270"/>
    <dbReference type="HOGENOM" id="CLU_161800_0_0_2"/>
    <dbReference type="OMA" id="EMFSWIG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-625-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12044" checksum="4021D56E41A2DFC8" modified="2012-11-28" version="1">MNAQAKKNGQKFEAKLSGYTMQTTKFGNFEMIVWTGDWSAARSIIQKASGKMRAKVIESGYHEKRDLLSAMFGSSSEYGKVYSNGKLVGQIETVKRSGKWMAKTESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDF7</accession>
    <name>K0IDF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57670">
        <property type="protein sequence ID" value="AFU57670"/>
        <property type="gene ID" value="Ngar_c07270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07270"/>
    <dbReference type="HOGENOM" id="CLU_3003262_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-725-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6525" checksum="34A19B7ADE92399F" modified="2012-11-28" version="1">MYALLLFNVWSTLVEGGRFINGNQIHPTLEKVWVFFGSHTLHYEKISSRDSKILMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE04</accession>
    <name>K0IE04_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh4</name>
        <name evidence="4" type="ordered locus">Ngar_c26800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26800"/>
    <dbReference type="EnsemblBacteria" id="AFU59601">
        <property type="protein sequence ID" value="AFU59601"/>
        <property type="gene ID" value="Ngar_c26800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26800"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2655"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="OMA" id="QYAHNVF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="350" mass="37108" checksum="DC72E19607A41354" modified="2012-11-28" version="1">MKAARIIKTKEPLEIKDVGVPKPKNDQVLVRVESAGVCHSDLHLWEGGYAGPQGVFMKVEDRGVKFPLTPGHEIAGTIEEMGESVTGFSKGEKVLVYPWIGEGTCPACRVGEENVCDAPRSLGIYQDGGYSEMVLVPSHKYLVKLQGLDPNSAASLACSGLTAYTAVKKAGAQPGDTLVIVGAGGLGLMAVQIAKSITNARIAIVDIDDKKLAEAKRLGAHEVINSGASDSVKGVKDITNNFGAEAVIDFVNNAKTAPNSLNMLRKRGRLVMVGLFGGSLELNLPLIPLRAFTLTGAYTGKFADLVELVALARMDKIQSVVSRKFTLDQANSALEELKSGKIIGRAVINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE33</accession>
    <name>K0IE33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenical resistance-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57078">
        <property type="protein sequence ID" value="AFU57078"/>
        <property type="gene ID" value="Ngar_c01280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01280"/>
    <dbReference type="HOGENOM" id="CLU_077102_0_0_2"/>
    <dbReference type="OMA" id="MEIGIHN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-128-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="297" mass="32012" checksum="B5F6CE2D6DA2BE8F" modified="2012-11-28" version="1">MRHNDVVLAACIAGSMSAGVLLPSAGLLVEPYILVWLGALLFLNLIRLKTSDLLATFTKPRQLAVLSAVKLAALPVGMYALVYFVYQPFALPVLLLSGISTGLGAPFVVNLIGGRLPLIVGMIIATSLAVPFVLPSIVYALVGSQFDIPVIDMVFLLSAALFTPLAAGWFTKKRFPVASRFVDEKSFPLSLVFIVLINFGMFAKFSSYFYEEQVFLLQTIATAFICYAAYSLVGYASAPGGQQERSAGLIAMSYVNNVLVAVFAFQFFGSQVAALAALYNIPYYVGIVAIKRFMPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEF6</accession>
    <name>K0IEF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58155">
        <property type="protein sequence ID" value="AFU58155"/>
        <property type="gene ID" value="Ngar_c12150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12150"/>
    <dbReference type="HOGENOM" id="CLU_1840644_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1213-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15467" checksum="FFEE948F83226EC8" modified="2012-11-28" version="1">MLGGRRHLHIDPQDQPNDWLSKALKSASSGMLAIDFENRPVVRVTIDNGTLAVDLLQPDIFKTPQDEIGLFDKLKTATEFGRKLSDNDVTISFLRRGKEAVRLGKDAKPTLSKLITRSDDVQMTSVKEFAGLKSDLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEG0</accession>
    <name>K0IEG0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59726">
        <property type="protein sequence ID" value="AFU59726"/>
        <property type="gene ID" value="Ngar_c28060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28060"/>
    <dbReference type="HOGENOM" id="CLU_3338596_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2806-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4272" checksum="11FCA7668A2A4194" modified="2012-11-28" version="1">MPKGVCLQCNEPSMVWCEACFLVEEYLHVGHTELDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEJ2</accession>
    <name>K0IEJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58170">
        <property type="protein sequence ID" value="AFU58170"/>
        <property type="gene ID" value="Ngar_c12300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12300"/>
    <dbReference type="HOGENOM" id="CLU_131895_0_0_2"/>
    <dbReference type="OMA" id="PRYWRGH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1228-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="16290" checksum="F27630EA25EEE01E" modified="2012-11-28" version="1">MANIPHTGKSKAMVTINASREVSAPLDKVWNIVADVDNEPQYWHGTKTVKNISKSGNTIEREVTIAFKDSKCRQTVVLDPKKSVGITITEGPLKGTKVVTLSPTSGNGTRIDVVWDIKLAGFLGMFTGMVKKHIAEGTEEALERIAKAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM8</accession>
    <name>K0IEM8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57233">
        <property type="protein sequence ID" value="AFU57233"/>
        <property type="gene ID" value="Ngar_c02850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02850"/>
    <dbReference type="HOGENOM" id="CLU_2581530_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-285-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9315" checksum="3F50FA4232DCCE2E" modified="2012-11-28" version="1">MCKCRDEIESSKHNKEEGKRQENDDFSHQIEIVFTMLIIFRRISGFVPQNKQESNMVHGIFFTCWANAGFSAFSRHSPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEQ4</accession>
    <name>K0IEQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03200</name>
        <name evidence="2" type="ordered locus">Ngar_c03500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57268">
        <property type="protein sequence ID" value="AFU57268"/>
        <property type="gene ID" value="Ngar_c03200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57298">
        <property type="protein sequence ID" value="AFU57298"/>
        <property type="gene ID" value="Ngar_c03500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03200"/>
    <dbReference type="KEGG" id="nga:Ngar_c03500"/>
    <dbReference type="HOGENOM" id="CLU_1159086_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-320-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="239" mass="27643" checksum="857C814835D84F70" modified="2012-11-28" version="1">MSYSGFFSINNSLDDTTKALLKFYLPDGGVIYDPTCGEKNYQFSWLKKSSTIALDYYCNITGRRGKAVLQQQAKEHYRYICSDLKPTGDFIANVSHLPLKNKCADATWYDPPFAPTRDSKDPRAKAFGVNENRTPKQIKEFYSADILKELARVTKKFIFVRGQDIYFPPNTTNFYPFYEMALHSVKKVKELEKKPIAEYTLRYNHGKLPLFRYRLRNVQRPIITYSKIAVLKVKEGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEW0</accession>
    <name>K0IEW0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13670"/>
    <dbReference type="EnsemblBacteria" id="AFU58305">
        <property type="protein sequence ID" value="AFU58305"/>
        <property type="gene ID" value="Ngar_c13670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13670"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OMA" id="MMVIEEQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1365-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8395" checksum="93F82E693E5EE4AC" modified="2012-11-28" version="1">MAEAYVLINCDLGTEDGVIKELKSISGVSEVKGVFGVYDVIAKVNAPSESDIKKVIAKIRSMSSIKSSLTMMVIEGQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEZ1</accession>
    <name>K0IEZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30080"/>
    <dbReference type="EnsemblBacteria" id="AFU59926">
        <property type="protein sequence ID" value="AFU59926"/>
        <property type="gene ID" value="Ngar_c30080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30080"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2980"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OMA" id="WGLYNTK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3008-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="15"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="349" mass="38204" checksum="77AA0A36D64DEE87" modified="2012-11-28" version="1">MKAAVYREHDKDPKKVVRIEDVEIPTLKPNEVLIKVEASAYNYNDLWGIWGEPIKIPLPHISGSDVAGTVVEVGEDVTKINVGDRVVSHPNLTCRVCYECTSGREYDCSSRLVWGFQTGPLWGGFAQYTHLPEVNVVKLPDNVSFNDAAAISMVGMTAWHMLVTRAKIEPGQTVLIMGGGSGMGIAGIQIAKLFNCDVIATAGNKEKMDKCIELGADHVVNHREEGWHKKVREITNKEGVDIIYEHIGKTVFPQEVGLLKMGGTLVSTGATTGYDSTIDLRYLFFRGINLLGATQGTKAGLEQVIGWVSKGKIKPVIDTILPFSNMVEGHIKMADSQLFGKIVTTPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF14</accession>
    <name>K0IF14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04460"/>
    <dbReference type="EnsemblBacteria" id="AFU57393">
        <property type="protein sequence ID" value="AFU57393"/>
        <property type="gene ID" value="Ngar_c04460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04460"/>
    <dbReference type="HOGENOM" id="CLU_532802_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-445-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="511" mass="54934" checksum="18BC0A4A7EED07F8" modified="2012-11-28" version="1">MISTYPWKDGARFFIPGILLLVAAIADIPASVQQEQGYSSESLFMAVFPNGDALVEYDVSINNPLAQEIRIKLFGGAHINDLIVADYEDQLVDYDIGSSPNEIVLDTPGVENIRISYSTPDLANRIQGIWTFALNATTAFSVRLPPDSVLVDYEPIPAAIKIVPTNQPLLTFDEPGEIRVSYAIGVLGTEDQANIAIQLANVAIRETEEGHPGIILTGAKDLLQRAIVARDDGKFAEAESLAGRANDAAVTTGRAYEDAQSAIAAADTQIDQAASEGRDIVSARQLLEQANDEFAGGNYTAAASSAQNAIKAIGARPPDPQVPVAAIVAGAVAAAGGVGALVFLKMRKPTLLTPQQQKRDPPKVSNNNSRTTAIIRPPEVKEAEEEKGGKKPAGGVVGEPLEEEVSSAPVVEPGAIPDSQNDRSVLGRIVGRILEEKPHLRPEDQQVLKFLAEKEGAAFESEIRSKFQLPKTTIWRLVKRLEREELVEIRKAGGQNLIKLKFEDRMPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF30</accession>
    <name>K0IF30_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58385">
        <property type="protein sequence ID" value="AFU58385"/>
        <property type="gene ID" value="Ngar_c14490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14490"/>
    <dbReference type="HOGENOM" id="CLU_2103624_0_0_2"/>
    <dbReference type="OMA" id="VKFRASI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1447-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="13973" checksum="8107E009C17D9F41" modified="2012-11-28" version="1">MSEQKQISISLAEDSIAADEELHGTVVINYHGRFDSLVINSQIENSSDVFSYINLNGKKIKHPYARLSIFKAELGGRTTIEFTATTNHVPADDHSSVKFRVSIIQEHKEVASDIAYIKIVKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFH7</accession>
    <name>K0IFH7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-3-methyladenine glycosylase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06400"/>
    <dbReference type="EnsemblBacteria" id="AFU57583">
        <property type="protein sequence ID" value="AFU57583"/>
        <property type="gene ID" value="Ngar_c06400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06400"/>
    <dbReference type="HOGENOM" id="CLU_000445_72_5_2"/>
    <dbReference type="OMA" id="RTVAAWY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-638-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="55"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="23911" checksum="11BF3EAAA0D7743A" modified="2012-11-28" version="1">MIIAMTAKQVAKEEAEALKHLAAADARLAAIIKSVGAYEIKLRKDPFQSLVEAIIYQQLAGSAADAIYGRFVKIYGRFPRPAQLLATPDSKLRACGLSARKIEYLKDLSSQVSDDRLKLALLPKMPDEQVIEQLVQVKGIGRWTAEMFLIFCLGRPDVLPVGDLGLRKAMQQVYSLAELPSPARMREIAQLWKPYSSIATWYMWKSLEKFKGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFT8</accession>
    <name>K0IFT8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpn1</name>
        <name evidence="6" type="synonym">rnp1</name>
        <name evidence="7" type="ordered locus">Ngar_c17370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17370"/>
    <dbReference type="EnsemblBacteria" id="AFU58670">
        <property type="protein sequence ID" value="AFU58670"/>
        <property type="gene ID" value="Ngar_c17370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17370"/>
    <dbReference type="HOGENOM" id="CLU_107020_2_1_2"/>
    <dbReference type="OMA" id="NVLVHEI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10041" checksum="9AB511CCC6D83913" modified="2012-11-28" version="1">MTSPENVLVHEIIGLDAKIVESTDPTLEGVSGSIVFETKNMISIRSDLDSSVKQIAKRAAKKIEIKTHFGVCFISGSSLIGRPEDRISRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFW7</accession>
    <name>K0IFW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58685">
        <property type="protein sequence ID" value="AFU58685"/>
        <property type="gene ID" value="Ngar_c17520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17520"/>
    <dbReference type="HOGENOM" id="CLU_151093_0_0_2"/>
    <dbReference type="OMA" id="HRARGMI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1750-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="14174" checksum="46ADB2ABB4D77663" modified="2012-11-28" version="1">MAKGIATGLLVASLILLIIYGADAAVAASSPDRMGFVPLDEAARGAGLGGGAVVMSIIGFVIARKEHAPIVSTLLFVNGGLIIAGMLALIAQGALASEDSSGAMRTIGSTMAMGAILIGLGAWKVAIDKRTIAAKGKEQAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG13</accession>
    <name>K0IG13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c17920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17920"/>
    <dbReference type="EnsemblBacteria" id="AFU58725">
        <property type="protein sequence ID" value="AFU58725"/>
        <property type="gene ID" value="Ngar_c17920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17920"/>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_2"/>
    <dbReference type="OMA" id="KWIDQAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1790-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17389" checksum="64EB0D5F4FB25929" modified="2012-11-28" version="1">MKKKSPSESKTEMTLMMLPSDANPKGNVFGGVILKYVDLVAGIVSKRHARNTNCVTASIDRMTFLKPVYIGNALILSARLNYVHRSSMEVEVTIEAENLDDGTRVRTGTAFVTTVALDKNGKPTEVPQLVLKTADDRKRFKEGYARMQSRLKEAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG47</accession>
    <name>K0IG47_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c34660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34660"/>
    <dbReference type="EnsemblBacteria" id="AFU60381">
        <property type="protein sequence ID" value="AFU60381"/>
        <property type="gene ID" value="Ngar_c34660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3465"/>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_2"/>
    <dbReference type="OMA" id="SGEIMGY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3467-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:peptide alpha-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="PTHR23091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20981" checksum="A0F5CA4F68057E3B" modified="2012-11-28" version="1">MSLQRPVKLNSVFLLLVAALQTALRKVGDYIIRRCDESDLESVININMAALPEHYSDYFFESILRELPEAFIVAELDGKIVGYIMCKIEFGFSNFRKLGFVKKGHVVSVAVLEEHRGKGLGKALMLEGINGVMQRKSDEIYLEVRISNTGAIKMYEKLNFEIKSRLRSYYRDGEDAYLMALELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG65</accession>
    <name>K0IG65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-isopropylmalate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08660"/>
    <dbReference type="EnsemblBacteria" id="AFU57808">
        <property type="protein sequence ID" value="AFU57808"/>
        <property type="gene ID" value="Ngar_c08660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08660"/>
    <dbReference type="HOGENOM" id="CLU_075000_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-864-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="304" mass="32950" checksum="A195D017D30D4F0B" modified="2012-11-28" version="1">MIITCNSALEKKNANEDSVVRKGHSDSVIESLDGKSRIKPVTISSNVVEAIKQDAAADQDEHRANNKKRGPVLIVGFPGVGLVGSICANYIIEKKNLHQIAFVDSEYVVPSAIYIGGKLRHPFRIYADDTSTLCVMVCEAPLRPDGVHSIMDMVVAWALRSNISELLILDGMPVRGLPAKNRKPVVLSSSSPADAPKDHSVKGAMMVGLSAGLISACLSDGMSCTAVLIPSTSGIPDPEGAAILLETISRMPTIPLEIDVEPLRHEGQIIKRQLKEFIDSVRKEQQEEEDEGKGRYLRSSRIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGB6</accession>
    <name>K0IGB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chaperone, dnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c35330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35330"/>
    <dbReference type="EnsemblBacteria" id="AFU60446">
        <property type="protein sequence ID" value="AFU60446"/>
        <property type="gene ID" value="Ngar_c35330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35330"/>
    <dbReference type="HOGENOM" id="CLU_1232812_0_0_2"/>
    <dbReference type="OMA" id="DFWKEYE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3534-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="22490" checksum="BE73F26E926FB393" modified="2012-11-28" version="1">MICPILADSKGYYAVLGVSEKASYKEIRHAYRRLARKYHPDRNNSAFAEEMIKKINAAFEVLSDETKRAQYDRSEFDSAPEPEPTYEPEPVQQPNSPEPWKMANENVVADFFNGPYFLDTPKGRFHIIVEPSLCMAFGSCETLAPKVFVVEKNKRVNPKAVVECETCADYERIHAAAATCPTKAIKIIDRYTGEQLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGD3</accession>
    <name>K0IGD3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57888">
        <property type="protein sequence ID" value="AFU57888"/>
        <property type="gene ID" value="Ngar_c09460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09460"/>
    <dbReference type="HOGENOM" id="CLU_1088268_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-944-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="29159" checksum="F77F396E2C52ECF1" modified="2012-11-28" version="1">MMQLEQRDYSQLFGELEYYRNRCSELEVENKRLREELQSLKATLSAVVAKSIDVKPTVKRKRSKKPGRKKGHVGKSRKRPEHIDARVTIDQTSCSIYVARVPCLQSLQARTAASLQISYLQGPWLEYTVKRRYCSSCKRQVSPPVPGVLPNEVFGLRLMLLIVSLKLLGLSYEKISGHFQLLFNLNITDAAINHAVMKVAEAFDPRYNQLVETTCRKRRTSPEATKQVAYKRQEPLAVGVCGKAWTVVYEVDRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW5</accession>
    <name>K0IGW5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11470"/>
    <dbReference type="EnsemblBacteria" id="AFU58088">
        <property type="protein sequence ID" value="AFU58088"/>
        <property type="gene ID" value="Ngar_c11470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11470"/>
    <dbReference type="HOGENOM" id="CLU_1700200_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1145-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15322" checksum="28C69683287B7F3E" modified="2012-11-28" version="1">MQKSNIRQIALDQSMLHYFKGRVEIKKMVTDALTKEVETFLVTFIDGARTKLHYHETDQVLIAAEGKGIVVVQTGVKMEDDTAATVKMDDVHYLNEGDFVCVPAYKWHWHGAVKGSNFAHYQIKKPGRTVWLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX5</accession>
    <name>K0IGX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57067">
        <property type="protein sequence ID" value="AFU57067"/>
        <property type="gene ID" value="Ngar_c01170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01170"/>
    <dbReference type="HOGENOM" id="CLU_1850700_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-117-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15221" checksum="A1CE182C4C8ADECF" modified="2012-11-28" version="1">MLTNLDELERAAAKYAELKRGENNAELAQIAGTIVDSISLPSFSFPLKEETLSSNGTTTYVYENNATFPALYDFLGELLHSKVPLEIREAKFGPGEIIVARQSKEEADAALDMSIKELQELVHARESEILSKYAADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH33</accession>
    <name>K0IH33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58138">
        <property type="protein sequence ID" value="AFU58138"/>
        <property type="gene ID" value="Ngar_c11980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11980"/>
    <dbReference type="HOGENOM" id="CLU_2613751_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1196-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8868" checksum="6AF789EA57874FC8" modified="2012-11-28" version="1">MRDPAKVKYEVLSAVLESSSRHLEESTKNIEEIRSILHWAKSPRERTAINIILDDQRKVAKALGRLVDDLSEISSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH83</accession>
    <name>K0IH83_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59255">
        <property type="protein sequence ID" value="AFU59255"/>
        <property type="gene ID" value="Ngar_c23290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23290"/>
    <dbReference type="HOGENOM" id="CLU_1346448_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2327-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="18334" checksum="261573A52277CFBC" modified="2012-11-28" version="1">MRRGVWGLILSALAFSVSYAFVEYYIIRDTTFGYNPVLFSLLYPYHFAMAAVFVIAAYGLLCAHVSVKGIVPSLVIAGALFSSMLAIEDFVWFVLRAAAPVHGDANAGKLVVAGEWTTQFMGSVDAHFTAIPNWYFLSIGFSAAALGTTRRRQRQQLTAAASDHLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP8</accession>
    <name>K0IHP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative UDP-glucose-hexose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galT</name>
        <name evidence="10" type="ordered locus">Ngar_c15340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15340"/>
    <dbReference type="EnsemblBacteria" id="AFU58468">
        <property type="protein sequence ID" value="AFU58468"/>
        <property type="gene ID" value="Ngar_c15340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15340"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1498"/>
    <dbReference type="HOGENOM" id="CLU_029960_1_0_2"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="9">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="343" mass="37969" checksum="950DE6480D5DC36E" modified="2012-11-28" version="1">MGDLRKDYVLDKFVVVPEANQAATAGDKPEGSKCPYCPGNESMTEPALLALVVQDGMLQRLSDSEDSIIEDWSVRVFQSKNPVVATGAATSYSDKPLYSEPAYGYHQIVVASPDHKQSLSQMSVEQWGNVLVVIQDRVRWLYTQKSVTYVSIYVNSGVGAGAQVAHPHLHIVTFSTIPPVIELEAEGSHRFMNENGNCPACNIIGVESSGPRQILATDSFLAFCPWAPTYPYEFWIYPKRHITSFSKITQKEINDLALMLRATLGGMSKALKDAPFNLVFHLSPEKKNSRQIHWHIEVYPQLNTWSGLERGFGVFVNNVRPEKSAEILGSASRKELAGLVGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT2</accession>
    <name>K0IHT2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57417">
        <property type="protein sequence ID" value="AFU57417"/>
        <property type="gene ID" value="Ngar_c04730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04730"/>
    <dbReference type="HOGENOM" id="CLU_929434_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-471-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="299" mass="33154" checksum="3EF772AF4B6F2ECC" modified="2012-11-28" version="1">MYANALLNAFTIIAFFLLVNQPGKHIYAQENVNETGTSIPSNQNLPNTEASVASMQVQWIQLSLQFVIGGLVAGFALYFANRLLDHYRRPILRIAKDKSPVLRAFHSEVYSVSSPLLGAIPSIKTKYLVEYVANRIIVRNDGRNAAENCKAVLRIDGNEEKVAWISPTSGHTMTINANSVEYVDLCAILKGDQAQIVNDIRTEVSKLPTSGTNSYTKQTEVYEDSIKARTEVKKHYQSPDALPRVIAPTEDGWQQPPHRNRILAPTKAQIVITAKNAEPCVVDIEILAQPVDGRAIKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV7</accession>
    <name>K0IHV7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="6">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c05340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05340"/>
    <dbReference type="EnsemblBacteria" id="AFU57477">
        <property type="protein sequence ID" value="AFU57477"/>
        <property type="gene ID" value="Ngar_c05340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05340"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.510"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="TIEGMTG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-532-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="213"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="486"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="725" mass="79494" checksum="71C7EDDF8B93D0BD" modified="2012-11-28" version="1">MKNDAKVTLKVAETNPKFVGRGMALIDPRVMEEMGLSTGDVIEITGKKKSYVLLWSSQSEDYGKGLIRIDGYTRNNIGVGIDDSVSIRKVSVKKAEQVVLAPTEELNIVGLEEYLPELLEGRVVAKGDVIPLNIMGRRIGFAVTNTSPSDTASLIDSNTNFVIGAVPKAAAKGVPRVSYEDIGGLRNEVQKVREMIELPLRHPEIFERIGIEAPKGVLLHGPPGTGKTLLAKAVANETNAGFYSIGGPEIMSKFYGESEERLRQIFKEAEENAPSIIFIDEIDSIAPKREEVSGDVEKRVVSQLLTLMDGIKSRGKLVVIGATNRPNAIDPALRRPGRFDREIEIGIPDEQGRLEILQIHTRGMPLTEDVDLAAIARVTHGFVGADLEALSKEAAMRSLRRILPEINLEEARIPAEILNKIKVTRQDFEEALRDVQPSAMREVLVQKPNVKWEDIGGLGQVKEELAEAIEWPLKHADLFTEADVRPPKGILLYGPPGTGKTMIAKAVATTSEANFISIKGPELISKWVGESEKGVREVFRKARQAAPCVVFFDELDAIAPRRGGSEGDSHVTERVISQMLTEMDGLEDLKGVVVIGATNRPDIIDEALLRPGRFDRILEVPIPDKETRKQIFQVHTRRKPLDSDVNLDKLVEMTEGMTGADIASIVNAAAMSAIKEHVSSKNGGNKKLRISMKHFESAMDKIKTGSSAARTRGSFQNFPGSRSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0II22</accession>
    <name>K0II22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58583">
        <property type="protein sequence ID" value="AFU58583"/>
        <property type="gene ID" value="Ngar_c16500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16500"/>
    <dbReference type="HOGENOM" id="CLU_2299429_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1648-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11478" checksum="86C0FF469A933E35" modified="2012-11-28" version="1">MHEWKNVTSDRTAMLIVNIKRLNSKIKVFVIADRYLEETKTRILDYGADEFVLKPISIHSVIEKVSLLLLEAATNSTSKKSGLLLKRFLFCNLFLHGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0II35</accession>
    <name>K0II35_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ordered locus">Ngar_c16700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16700"/>
    <dbReference type="EnsemblBacteria" id="AFU58603">
        <property type="protein sequence ID" value="AFU58603"/>
        <property type="gene ID" value="Ngar_c16700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16700"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1647"/>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_2"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="81"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="115"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="357" mass="38070" checksum="DE2665945191AEA2" modified="2012-11-28" version="1">MSAQQPDLRPAIRKLVARTNLSDKEVSLALDAILSGSIPDAAISAFLVAFAMKGETAEELGSVLCSLQNHATKITPNVQGPLIDTCGTGGDSIRSFNISTAAAIVASAAGAKVAKHGNRSVSGLSGSADFFEYVGLDLNAPPAKVQSCIESTRIGFMFAPLFHPSMKHVAAARKAIGIRTVFNMVGPLSNPCTNISGQVIGVFEPTLLDVFAQVCQGRINEAMIVHAHDGFDELSNTCENDVLWVSGDRQTKRIRLHPRAVGMKVAKPEQLVVNSKEESIRSTLQSIYGKASKEKQDIVVLNAAAALVVSKIAHDFKDGVEIAGDAIKSGKAQDKLLQMIKYCGDIEKLKEAEKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0II83</accession>
    <name>K0II83_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutathione reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59655">
        <property type="protein sequence ID" value="AFU59655"/>
        <property type="gene ID" value="Ngar_c27340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27340"/>
    <dbReference type="HOGENOM" id="CLU_2115557_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2734-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12799" checksum="C4F3271C7040E85F" modified="2012-11-28" version="1">MEYQEKIVKGMMQLRTGKMREWSAEVIESRGALRSKNEVITEDGQILQADKILIGTGSKYHVPSVEGIQYAIDGDQVLKLRELPGEKRVFIIGAGFGGLEYATFNHLPNQSIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0II95</accession>
    <name>K0II95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57707">
        <property type="protein sequence ID" value="AFU57707"/>
        <property type="gene ID" value="Ngar_c07650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.738"/>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-763-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9751" checksum="8133F155636E039F" modified="2012-11-28" version="1">MTCKGICIRHKAQKPVGSGRYASGQKRCQICEIFIKWDGLWCPCCGYRLRTKPRNLKYKAKLRARTKKQQELKVAAKPITVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE9</accession>
    <name>K0IIE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57822">
        <property type="protein sequence ID" value="AFU57822"/>
        <property type="gene ID" value="Ngar_c08800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08800"/>
    <dbReference type="HOGENOM" id="CLU_1387627_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-878-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="19660" checksum="BC87264BFDC89BB7" modified="2012-11-28" version="1">MTLTRQKTLLLAVPAIGMVAILVMAFVLPIGALAGNKMSEQLGPHGYVTISVVRDGAEIYHYEDHNLITNAGMNFIATQLGNATAAPANYIALSNNTASPSVTDTTLAGEFTSGGLQRAQGTYSHTANTDNWTISKTFTATASATGVQKAGLFNASSGGTMMAENTFSPVNLANGDTLTITWTIDLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG7</accession>
    <name>K0IIG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09100"/>
    <dbReference type="EnsemblBacteria" id="AFU57852">
        <property type="protein sequence ID" value="AFU57852"/>
        <property type="gene ID" value="Ngar_c09100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09100"/>
    <dbReference type="HOGENOM" id="CLU_712932_0_0_2"/>
    <dbReference type="OMA" id="IQCAFIS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-908-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="383" mass="41541" checksum="B838A0A1E055062F" modified="2012-11-28" version="1">MPRFLPLTKGLGYVAMGNMVSAASAGLFWLLVASIISTDDYGILSYDLALISILGSVALIGSTTTVTTYVAKDELNIVKSFSLPLLLTTLACSAFLLFSNLPLQMFLALLGLSFFTITTAEKLGQRKFKEYMLMLIAHRVLQISLSVLLFYFLGIGGIILGYAAGYLTFSWPFIIHLLHFKTDLSSLRSHLRYTIHSYAVDLSKNLSLFADKLIIAPVFGFAILGMYQLGMQFLLLLAVIPSVFFSYTLPQEASGSKQKGTRIFGIVSTVILSLLFIVLAPSVIPIVFPKFSEAVPIIQLISIGALPMAIVYNTQSSLLASENTKPVFISAAIFVGSQYGLILILGHALGALGLAIAIVSALSIQCAFISLYSRHYALTRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0III3</accession>
    <name>K0III3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c19260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19260"/>
    <dbReference type="EnsemblBacteria" id="AFU58858">
        <property type="protein sequence ID" value="AFU58858"/>
        <property type="gene ID" value="Ngar_c19260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19260"/>
    <dbReference type="HOGENOM" id="CLU_306223_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1924-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="967" mass="104119" checksum="60385F35EB93689D" modified="2012-11-28" version="1">MIPSFVNLNSTPSLFSSVSAQQNDDSADIQDGECENLVVDDISSSNNIVGRQVAENVLDNNLGSLWIARGTSAWIQADLGESKIICDIEITWLRISPRQQYELKISISVDGINYDIVHTGRIAGNTMFIPQRYDLGEANGRYVKITVDMANANNLIGISNLVINGREDTTAEEEFTYTVDEQIEPSVKELPGIKGGPPRPVEAVVGPDGTQDEFVINEVIFRPRDQAELSAFIAKYNGTILDDGSPLLIPGANRTEDSTVPESSGWYLIRVDLERSSLNDLSSNMEQLNLTGQVVFSSQDAARLAALIARESDQDISPNFFARPGAVIEHPDYGGGNLDAERWTWMTEDDNPGAPGVQGLSVGTVNAWNYLRYMRIPPPPPSGIWSPAIVAIVDAGFDLDQTTGLPLNNNRDYFHLGDNLMQGDVVDHDLRAGGDYAGWHGQGVFGVALSRPRNGYGSAGTAGEIAYPMLIRIDGSFYHMADGIRTSVLNGANVINISWFGECNWWCRTFTGNDNAVESEVGLAVAGNAIVVSIPGNTQPLGQDIGDKYMIPCKVTGVLCVGAIMGNGQAELFSNYGNGVDIWAPDCTRSTVSRVSADDDVDDLGIDELWQFCGTSGAAPFVSGIVAMMKMPKPDMTLNEAVDILQRTSNPSTDPKVSLTGYVDAFRAVASLRENRPPSVNIILPEDGASITWGVFSGRATAQDPEQGGWFSNSIASITFTSNRDGRLCIATDRFGDYYYCQKRNLSLGSHRITAIATDIFGASGSDSIDIEVINHDPSPRIIWPPNNSEFRTGQSIEFRGFAYDLDESISDSNLSWTSNIDGPIGTGRTTSRTLSEGVHTITLQATDLYGATGETSIVVNVVSGVGIPEPEITSPRNGAQFFTGQTITFEGRAIDEEDGELPGSSLEWRSSRDSLLGTGNTISVVLSGPPTPCRPEFIGHTITLTATDSDGNSATSQIIVSVGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL9</accession>
    <name>K0IIL9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58908">
        <property type="protein sequence ID" value="AFU58908"/>
        <property type="gene ID" value="Ngar_c19760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19760"/>
    <dbReference type="HOGENOM" id="CLU_1212631_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1974-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="24625" checksum="034217A5961867C7" modified="2012-11-28" version="1">MAQTTPTLQIATFGNDGQEGIASGIRNFPIHKLALLCYSTDKQKAEEFAKKFANVLGIRVTVNVVARENVVRDTMERVSEILGREGREFQQVLMNVSCGDKLMGCAALSAAFVNGIKAFGMDEAGMPMLLPVLKLSYHEVISDAKLKILRSINDQGGSIESLEQLEQASGYGKPLLSYHVMGSRESKGLVDLGLLEVEKGDRGRILAKLTTLGKLLVISDSIRSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT1</accession>
    <name>K0IIT1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c29470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29470"/>
    <dbReference type="EnsemblBacteria" id="AFU59865">
        <property type="protein sequence ID" value="AFU59865"/>
        <property type="gene ID" value="Ngar_c29470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2922"/>
    <dbReference type="HOGENOM" id="CLU_007946_15_8_2"/>
    <dbReference type="OMA" id="TMIGIAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2947-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="6">
        <location>
            <begin position="467"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="758" mass="82385" checksum="CF1A990C464F5F24" modified="2012-11-28" version="1">MRTLSLMDIIMVGIAGMIGGAIFVLTGPAIGLAGDAVIIAFILNAIITLFTAMAYAELGSAMPEAGGGYLWIREGLPRPNAFISGWMAWFAHIIAGSLYAVGFGAFMYYLLGPEVAGVLSEEPLLGIIPFDKVIAVVSIAAFTYINIKGTSETGKAGTIVTLIQLGTIFALIGAGFWTMYNNPDWTTNFADFMPTGVAGLVAAMGLTFIAFEGYEIIVQTGEEVKNPKKNIPRAIFISLAIVVTLYCLVAFVSIGSIFPEGIASWQFIGENGELGIMRAAEMFLPYGVFIVLGGGMVSTLAALNATTFSSARVAFAMGRHYNLPHKLSSIHPVNRTPHVAIIISGVIMAFVAYALPLADIAVAAGVIFLLLFTQVNIAVITIRRIYGDKLSYGFKTPLFPAIPIIGIFLKLGLALYLLVTQPLSWGITVLWILVGFALYRMYTFKREIQHYAPLVTSEGDLKRQDYRILIPYTPENPDRLIKYAIRIAKETAGEVNILRVITVPHQTPLSAGVAFADAAKRSFEPLEKMLDKENIPNHYLVRVSHDATEAILATIEEQKIDVLVTDFETLRRDRKLLTLMTCKVLAIRAENDALELEPEHVRIDADLKSQAIPAGEKKNMVVVYDGGEHSDVVLKATSWLEHSGRFKVGLLSINRGGGGERSSVTMQQDYLSQLGVELKEVQLTESSSKSADIMLSAASSFQPDLVVMGATVGGFSVFNNPDFLALLDQFNCPVIIARGFTIPGVHRAKSLLMRALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV4</accession>
    <name>K0IIV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11100"/>
    <dbReference type="EnsemblBacteria" id="AFU58052">
        <property type="protein sequence ID" value="AFU58052"/>
        <property type="gene ID" value="Ngar_c11100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11100"/>
    <dbReference type="HOGENOM" id="CLU_042894_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1108-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="320" mass="36920" checksum="DE2462B07B6955C2" modified="2012-11-28" version="1">MAALAVARDALQQSTKKLLTNSLLPSTDYSQYYQRASVSLRHALSFYSSAVYGNNIMFLPRWLPGYAATDPQYFRPDRWTYIYDHSPLVSTLEKYIDYSKLRPGGNPNARLIITAVNVLTAEPLTFDSTRQPITIKHLLGTSGYPLYGFPWVEVEKGLYAWDGSLLSNTPLREAIDAAPTVDKRVFIVENYPKKIERLPQNLPEVYHRARDIMFSDKTAHNIKMSKAITRYLQFIEELYEIVESNLEVCKIDKQILENIRHKYQKIIKEHGAEIKKIAYITREERFPYLYENTDFSPAGIKNLIKEGESKTRQVLQKIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ04</accession>
    <name>K0IJ04_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mvaA</name>
        <name evidence="4" type="ordered locus">Ngar_c30640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30640"/>
    <dbReference type="EnsemblBacteria" id="AFU59980">
        <property type="protein sequence ID" value="AFU59980"/>
        <property type="gene ID" value="Ngar_c30640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30640"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3036"/>
    <dbReference type="HOGENOM" id="CLU_033422_0_0_2"/>
    <dbReference type="OMA" id="GHMKMHL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="377" mass="40601" checksum="E4C6BD58F390A33B" modified="2012-11-28" version="1">MDNNKKKFYEMDRDERLEYVRKATGISDIETMLRPLAFEDADRMVENAIGVMSVPMGIATNFVINGREYMIPMAIEEPSVIAAASKAARIAKINGGFTAEADESLMIGQVQVVGAGRAAMQKKILKSKKQLLAIANSKSRSVIAIDLKVRQVRDTSPNKMGSMLLVELIVDTKDAMGANAINTMCEAIAPTVAEIAGGEVVLKILSNYATKRMARCKAVFDKEELGGSEIVRRILYAYALAHSDVYRAVTHNKGIMNGIDAVALATGQDFRAIEAGAHAYAARDGTYRSLTRWRRTREGNLAGEIELPLAVGIVGGVVNAHPTAKLALQILGAKSAKELAMAMAAAGLAQNLAAIRALSAEGIQAGHMRLHSRKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ85</accession>
    <name>K0IJ85_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol dehydrogenase zinc-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c22330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22330"/>
    <dbReference type="EnsemblBacteria" id="AFU59163">
        <property type="protein sequence ID" value="AFU59163"/>
        <property type="gene ID" value="Ngar_c22330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22330"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2231-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="36"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="373" mass="40616" checksum="19AE497D71092919" modified="2012-11-28" version="1">MVFIFYYIKVLSTAYHCLYQAQTEGEKEMKAVFVKGHSAVSVDDVKVPELASAGDVLVKMRACGLCGSDLEKVYGEYGMTSGRLGHEPAGEVMAVGKSVKDFAPGDRVFIHHHVACYSCHYCKHGDHTMCPSYQTSNITPCGLAEQFLVPEWNVSRGGLIKLPDSVSYDEASLVEPLACCIRAWNKCNFQKGDDVAVIGAGPAGLMHVLLAQAYGARKIFVIDINDFRLKFAEKYGVQAFNPMTDQDLAAKIRPATEGRGVDVCIVATGSMKALLQSFELTRKGGNIMLFGVPPKGSQISYDMSKLYSNEQSIIPSYAASEIETNEALKIIAEKQVDMTSLITHRFDIAKAADAVKCAHEAKDAMKVIVTANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ89</accession>
    <name>K0IJ89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60075">
        <property type="protein sequence ID" value="AFU60075"/>
        <property type="gene ID" value="Ngar_c31590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31590"/>
    <dbReference type="HOGENOM" id="CLU_3094231_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3159-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6716" checksum="060339DA9FA8B24F" modified="2012-11-28" version="1">MRESNTILIEREIREEETEGVPVCGHNLSRPVIDRVRYIEEIHYKIGSREYIENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL0</accession>
    <name>K0IJL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24640"/>
    <dbReference type="EnsemblBacteria" id="AFU59388">
        <property type="protein sequence ID" value="AFU59388"/>
        <property type="gene ID" value="Ngar_c24640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24640"/>
    <dbReference type="HOGENOM" id="CLU_1017869_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2462-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="31474" checksum="3A88E7494D1FD7BA" modified="2012-11-28" version="1">MAYSGFRASAESYKGNLSKKQFYVRLKRLRDLGLIEKRDSVYRTTTFGSLIYNGHVKTLEDILANYWNLKAIDVLKSRQDFPLQQKEKVIDEIIRNSSLKSIVNGTHLSGFSVVKDYNRLVLEVTKLLESAKNEVFMATRYYDPHFSKLMFHKIANEGLTMHLLDGLPDQISLENRLNAILRVPPNRETAEMVNNIIKSHRFDLRKANLSASFMVVDGTTVCYETTNYTSPEQFTLAVSHYDDPYLAQRFISYYHMLAKDAKVPQLLASVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL6</accession>
    <name>K0IJL6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60230">
        <property type="protein sequence ID" value="AFU60230"/>
        <property type="gene ID" value="Ngar_c33150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33150"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="OMA" id="ETECIIK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3315-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20537" checksum="41807FF4CB1C2056" modified="2012-11-28" version="1">MQCEKLMTYDRLASESLFVEFSPLRLSLPQVISQIVRSLPSSSVGSSLSDDKDRSKPRILYVDDESRITRVIKYGLERYGFVVDIFNHPKLALSSFQQGVYDLLLIDIRLPEINGLDLCNELLKVDPNVKVCFITAYELRQEEIKNKVLGLETECIIKKPVSFETLVSKINEQLHRDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJP6</accession>
    <name>K0IJP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58502">
        <property type="protein sequence ID" value="AFU58502"/>
        <property type="gene ID" value="Ngar_c15690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15690"/>
    <dbReference type="HOGENOM" id="CLU_1088269_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1567-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="28371" checksum="ECA6410C7E559D31" modified="2012-11-28" version="1">MVAKSGRKPKPAKDVIIKMKQAGASTSEIIAKLGIKTKEGKDYVYHVITEARNKGLLKPETALENPASPAPSSSGSDGLIIEEAPVAEEAQEVSGMYAERKNEEMPRANLPIFQHPTPDLTGENARQDITPPQDSNLDNPDVSAPVDEGTEIDLSDITELPIEIEDKIFRRRGLEPLTEQEKENIRNHGNVMIAKRIHLKHPLGDVINYAKAIIKPVLTRVVGRKFTKDVEEQEKEESDAMKEYERLQAKKQEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJY2</accession>
    <name>K0IJY2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative quinoprotein glucose/ sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16490"/>
    <dbReference type="EnsemblBacteria" id="AFU58582">
        <property type="protein sequence ID" value="AFU58582"/>
        <property type="gene ID" value="Ngar_c16490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16490"/>
    <dbReference type="HOGENOM" id="CLU_677373_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1647-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="73"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="420" mass="45039" checksum="F4D3527595C504F9" modified="2012-11-28" version="1">MERKLAIPLLIIIAVAVVMAAVSISLGYAGLNNNDTSGSVSANGTFSVLPDLNPPTLSDAGLRVEKVIEGLVQPTSMAFLDHDDLLILQKNDGRVRHVTNGTLQPDPVHEVSVDGVSERGMLGVAVANATGDSKTVFLYYTESDGGEIRNRVYRHDDWSGSGNLGGGTLILDLPGEPGPNHDGGKMIIGPDGMLYTVIGDLNRNGMLQNFPNGPEPDDTSVIFRVDRDGNAVNNGTNNKYYAYGIRNSFGLDFDPLTGILWDTENGPAGYDEINVVEQGFNSGWEQIMGPIDRTGRTTETLVQFEGSHYADPVFSWSVSQGVTDIEFLNSTKLGDRYAYNIFVGDINNGNLYFFTVNQDRTGLEIGGAGLEDLVADSDTEAQAVTLGTNFGGITDIETGPDGHLYVLSFSGSLYRIVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK14</accession>
    <name>K0IK14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphosulfolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26460"/>
    <dbReference type="EnsemblBacteria" id="AFU59568">
        <property type="protein sequence ID" value="AFU59568"/>
        <property type="gene ID" value="Ngar_c26460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26460"/>
    <dbReference type="HOGENOM" id="CLU_062679_2_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2646-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="SSF102110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="328" mass="36802" checksum="139D48800C2AAD35" modified="2012-11-28" version="1">MLDDLVKNRVDSKKPRKEGLTCTVDKLQGIDKENFSTLAPFIDVVKIYGALPMLISEESLKKKIKFYHDFGVRVSTGSTITEFAISESSLERFVKEAAKVGFDIIEVGENSIDLSIDQKRKISDLIQSAGLEFQWKVGKKDPRHQLGVDDTLEKIKEAVKMGSKKIVLEANEGVNVGIYDEKALVKWSFVGAITNEYPPSTFIFEAPLESQQSALIAEFGQRVNLAEVHPDAIASVESQRRGFLSKSAFGVSYLRRNPEGGPAAKFIYFVIRTKHPIEQSELVSMSHLPRRTVQAAVEDLKRQGLIIERNSLDDARKKVYQPVQSDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKA7</accession>
    <name>K0IKA7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c18390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18390"/>
    <dbReference type="EnsemblBacteria" id="AFU58772">
        <property type="protein sequence ID" value="AFU58772"/>
        <property type="gene ID" value="Ngar_c18390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18390"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1821"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_2"/>
    <dbReference type="OMA" id="PDNHPSE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1837-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="4">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="366" mass="39067" checksum="4C00BEB2879927ED" modified="2012-11-28" version="1">MVTVDQVLNSLKKVVDPELHKDIVSMGMIKDLSINDGKVAFTLELTTPACPFNSDIERDVRTAMASLGVKDLNMRVTARVMEGRALSMDELLPGVKNIIAVASGKGGVGKTTVSVNLALALAKTGAKVGLLDADIYGPSVPLMLGLKASPEVVNNKIQPPMVEGIKVISMGFFYEQSQQAGIYRGPIVSGIVKQFLTDVNWGELDYLIIDLPPGTGDAPLTIAQTIPITGILIVTTPQDVAMNVAVKAIGMFNKLNVPIIGVVENMSYLQCPHCSEQVYLFGQGGGKKISDEFKIPFIGEIPLHPQIREGSDTGNPSVMSQPESIQSHAFTKAAKVIAGRISIIATEMQAQEQAEAKAASEQAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE0</accession>
    <name>K0IKE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59698">
        <property type="protein sequence ID" value="AFU59698"/>
        <property type="gene ID" value="Ngar_c27770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2749"/>
    <dbReference type="HOGENOM" id="CLU_046519_3_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2777-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="21763" checksum="2F9E47D3C5B083FB" modified="2012-11-28" version="1">MQLYIGCSGWSYSAWLGHFYPKGLEGAKYLEYYSMVFDYVEIDSSFYRIPSQLTVSRWEKVTPDDFRFTAKFPKSMTHDMRLGEGIESDLEYFYKAMTPLAGKLGCLLLQLPPSMTMKEGLKKLQSLPFDKRFRYAIEPRHESWFDEEVYSFLKKNELCLAWTQQDKIQTPSCNNRFHLPSIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI7</accession>
    <name>K0IKI7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(R)-hydroxyalkanoic acid synthase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phbC1</name>
        <name evidence="2" type="ordered locus">Ngar_c20300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20300"/>
    <dbReference type="EnsemblBacteria" id="AFU58962">
        <property type="protein sequence ID" value="AFU58962"/>
        <property type="gene ID" value="Ngar_c20300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20300"/>
    <dbReference type="HOGENOM" id="CLU_035017_0_0_2"/>
    <dbReference type="OMA" id="RCHETID"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="457" mass="52132" checksum="8D3B9626697246AC" modified="2012-11-28" version="1">MDMNQLTSTFLDACLYGLKLSNIYNSVYLRAFQKAVTEERKGVIEAAMGGGGKGTISYNTVESIYNKWLKNVDEELEAELKSEHFTSLLSRYTRLLLEQRSIFRKAGYPVDYLDRLFDWYVRSHLVFSLIPKESHLAPYDVVYRKGKARLLHYRAFGQEAPTAKKQPLLIIYAPINTFHILDLNPRRSVVRDLLTSDGLDIYLLDWGYPDWNDNHLSLEDYLGYVNDAVIVVKDQTKENKISILGYCWGGIFALIHAALNPEEVRNLVLMAVPIDFSKDDTILARWSKVIDVDAMMDEFGHMDGQALDLGFLMRNPPRYGFDKYLKLFQKTYDSEFVDTFIDVERWLYDTPPIPGVLHRQIINDCYKNNLLVSGGMEIAKDGKKQKVNLKKISVPVLSIIAEKDDLVSPASSAAINDYISSQDKSVLNNPGGHVALCISSNAHRKLWPEVAKWLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM6</accession>
    <name>K0IKM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21160"/>
    <dbReference type="EnsemblBacteria" id="AFU59047">
        <property type="protein sequence ID" value="AFU59047"/>
        <property type="gene ID" value="Ngar_c21160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21160"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2098"/>
    <dbReference type="HOGENOM" id="CLU_031618_1_7_2"/>
    <dbReference type="OMA" id="EGSLTEW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2114-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="154"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="29980" checksum="1EFC5F225A35E13F" modified="2012-11-28" version="1">MSLVMSAPELRRMLGNRNLLLVDTRPFSSYADSHIPGAVNIDLMQFHWIDTSKQGMAQFNKQATLLLSNIGVSKDKMVVFYDDVSGSSAARGVWLLLYFSHDKVAMLDGGFNKWKAEGFKTETKTHPFVHSNFNGKPDPRILADFSHIKSAIKKKKTVIIIDARSKEEYDGSAVRAAHAGHIPTAINIDWKDNLEQDAFKSLDKLEQMYKIPKDVEVITYCQGGYRAANSFVVLKMLGFKNARMYLGSWGEWGNRLDLPVETSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP5</accession>
    <name>K0IKP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59888">
        <property type="protein sequence ID" value="AFU59888"/>
        <property type="gene ID" value="Ngar_c29700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29700"/>
    <dbReference type="HOGENOM" id="CLU_2730547_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2970-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8338" checksum="469C263EA24EAABF" modified="2012-11-28" version="1">MARMQYHYNVTQDFLYPKVDIDSIMEKLMIHICQECDKIFFFSNEAANHLQETGHTSLKIIDNGSELDDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP7</accession>
    <name>K0IKP7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59893">
        <property type="protein sequence ID" value="AFU59893"/>
        <property type="gene ID" value="Ngar_c29750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29750"/>
    <dbReference type="HOGENOM" id="CLU_198712_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2975-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7303" checksum="62E2389E7F8146D6" modified="2012-11-28" version="1">MSKSNNCINNEHGSCKGIIKEADLTKICVCPCHDSMYQLVRNTIAVVNQNQRNNPYQFTHDSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR3</accession>
    <name>K0IKR3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps13p</name>
        <name evidence="4" type="synonym">rps13</name>
        <name evidence="6" type="ordered locus">Ngar_c21870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21870"/>
    <dbReference type="EnsemblBacteria" id="AFU59117">
        <property type="protein sequence ID" value="AFU59117"/>
        <property type="gene ID" value="Ngar_c21870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2166"/>
    <dbReference type="HOGENOM" id="CLU_103849_0_0_2"/>
    <dbReference type="OMA" id="IRAYRGI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="215" mass="22153" checksum="A99D78EC99170E92" modified="2012-11-28" version="1">MNLSASEYKHILRIAGKDIEGSKKVIVAVSEIKGIGYNFAQVLTQTLNINPDKRVGFLTDSELGELEQAIAHPDKAGVPAWYLNRRKNMDTGSNHHMITSDLDFASSNDIEREKMVMSWRGYRHMFGLRVRGQRTRTTGRKGGAVGVKKVKAMPGAAPAAAGAAAPAAPAAAGSAKPAAGAAASAAGAAKPAAGAAPAAGGGAKQAAPAKEQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR4</accession>
    <name>K0IKR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59923">
        <property type="protein sequence ID" value="AFU59923"/>
        <property type="gene ID" value="Ngar_c30050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30050"/>
    <dbReference type="HOGENOM" id="CLU_2505066_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3005-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9135" checksum="0AD718F927C9DB60" modified="2012-11-28" version="1">MTQLRTHIDNANSALEEDDTQAAMGHIVLALEEIEMILGGNVTWTANATDTETAAAMGNATAMTDDTEMNSTARESDDTETQMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL79</accession>
    <name>K0IL79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine sulfoxide reductase B</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">msrB</name>
        <name evidence="3" type="ordered locus">Ngar_c32980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60213">
        <property type="protein sequence ID" value="AFU60213"/>
        <property type="gene ID" value="Ngar_c32980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3289"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_2"/>
    <dbReference type="OMA" id="CDVPLFS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PTHR46081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14610" checksum="E4943A4BFBA41B6C" modified="2012-11-28" version="1">MSYHYNKLTPEEERVIVHKGTEPPFTGEYDNFYKEGTYVCRRCDQPLFSSKSKFDAGCGWPAFDDSFPGALKRLPDPDGIRTEIECAKCGAHLGHEFIGEQLTAKNTRECVNSLSIRFIPAEQKKSDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL90</accession>
    <name>K0IL90_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60243">
        <property type="protein sequence ID" value="AFU60243"/>
        <property type="gene ID" value="Ngar_c33280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33280"/>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3328-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="7351" checksum="DE12C880FADBC087" modified="2012-11-28" version="1">MVCRNICEKYRATKNKGSSPYAQGYKRCQVCDLFIKWSGTRCPCCQRTLRTKPHNKEAWYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA6</accession>
    <name>K0ILA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59397">
        <property type="protein sequence ID" value="AFU59397"/>
        <property type="gene ID" value="Ngar_c24730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24730"/>
    <dbReference type="HOGENOM" id="CLU_157016_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2471-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12992" checksum="0EE82DB583EB6B49" modified="2012-11-28" version="1">MNNQELCKAVAGLHGSVEVAMVLSNGKIVGSYLKSGGPVPDEDEFRYMISQIEMIVRATKANEDKFGELGFITIHYKYIDGLFFPLNDRDTLIVGAVQPYDHDALTGKILTLLVRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC6</accession>
    <name>K0ILC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25040"/>
    <dbReference type="EnsemblBacteria" id="AFU59427">
        <property type="protein sequence ID" value="AFU59427"/>
        <property type="gene ID" value="Ngar_c25040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25040"/>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_2"/>
    <dbReference type="OMA" id="IHHICYE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2503-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15360" checksum="124B614DE9F31379" modified="2012-11-28" version="1">MRVDHIAIAVKNVEEALKNYQKILNVDHLEIEEVPNEKVKVAMLMLQDTRIELMEPTAPDSPISKFLQDRGEGIHHIAITADDIEKDVARASANGMKMLGGLRTGSYGRRITFIHPKSLNGVLTEFCEAPPANGKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC8</accession>
    <name>K0ILC8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60323">
        <property type="protein sequence ID" value="AFU60323"/>
        <property type="gene ID" value="Ngar_c34080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34080"/>
    <dbReference type="HOGENOM" id="CLU_2461869_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3409-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="9927" checksum="5D7C4E18E3398679" modified="2012-11-28" version="1">MSAINSSADCKYKNNCDRCDLDMQPNNSHSWRVHASIVSAAIVVISAKLENTQQTCRFLGCIEPKKEQSHQNIESSMYATILLLFQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF4</accession>
    <name>K0ILF4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00940"/>
    <dbReference type="EnsemblBacteria" id="AFU57044">
        <property type="protein sequence ID" value="AFU57044"/>
        <property type="gene ID" value="Ngar_c00940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00940"/>
    <dbReference type="HOGENOM" id="CLU_992538_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-94-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_2" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="280" mass="30855" checksum="E1252CAA17447332" modified="2012-11-28" version="1">MQENKFEVAFSKDSSEPASWFFIQARKAGALRTAAGARRSTDITIRGEPNNFEVSVGTGEWGKNIITSAPLFIVPIVGISATVAKLYVAKKFEDGLWKYIRDQAKFLEASASSASKRATTTTTDATTTVGVDSRSYDCDYIEGYPGWNKQIEGGKLVLFREKGGKNRLVFKSQDGRQIVIPAQNIAEATIISRKKGLHENDLMIQLHCKDENGKNIKPVLNLNDDIIRGVLAGINEIAGEDKGLRNLEQVHVSTDTKYCMNCGNQIQKEAKFCPSCGQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI5</accession>
    <name>K0ILI5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative (P)ppGpp synthetase I, SpoT/RelA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35300"/>
    <dbReference type="EnsemblBacteria" id="AFU60443">
        <property type="protein sequence ID" value="AFU60443"/>
        <property type="gene ID" value="Ngar_c35300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35300"/>
    <dbReference type="HOGENOM" id="CLU_1381348_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3531-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20195" checksum="35D5E04A2DE5568B" modified="2012-11-28" version="1">MSDFPKAGFARLLKFFTNTDDVVKLTRAFGLATKIHKGELLNKTEPYINHPLRVALILVEELQMRDADLACAALLHDAHGSIVDEELKEHGERVYSIVRAAATQASADDQFAAMSKAPKDVKYIRLAERLDSARSMKNHAFRDKMIRFKDETEKYVVPIATATDDRLAFKLSVALYELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL3</accession>
    <name>K0ILL3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L30p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl30p</name>
        <name evidence="3" type="ordered locus">Ngar_c02000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02000"/>
    <dbReference type="EnsemblBacteria" id="AFU57149">
        <property type="protein sequence ID" value="AFU57149"/>
        <property type="gene ID" value="Ngar_c02000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02000"/>
    <dbReference type="HOGENOM" id="CLU_055156_6_0_2"/>
    <dbReference type="OMA" id="KDYITWG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="2">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="17060" checksum="6F30E59A470D64A3" modified="2012-11-28" version="1">MAYLIVRIKGTVNIPRWAQATLNGLNLDRRFRATVVPESEEYLGMLRKVKEEVAWTKADAGIVKELLEKRGRKAGYKPITKSDLPKEYKSIDDLAAAIAENKVAMSKLEGIKPWFALSPPKGGFKRKTKTQYAQNGVLGEDGELVEIVKRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL8</accession>
    <name>K0ILL8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60498">
        <property type="protein sequence ID" value="AFU60498"/>
        <property type="gene ID" value="Ngar_c35850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35850"/>
    <dbReference type="HOGENOM" id="CLU_113182_0_0_2"/>
    <dbReference type="OMA" id="HIRMILI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3586-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="23431" checksum="1BA1E0B7A514CEF1" modified="2012-11-28" version="1">MDNMHKKTKPVRREMTKLIIRYQTETSLLHFKISRRRILYLVLGIAAFLIAYSVGAAIPMSEEEAEEVRRQFSEQIEGIDQNGIFFNNVRIALAMFIPALGAGFGAFSGFATGAVFSALASSTPLLADVPPLIILITPFGIMEVFAYGLAMSRSGMLIYQLVKKKPWREYVIPTFIELGIVVVVLFAAAVIEWQMIEQLGGLDTSVIIEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV4</accession>
    <name>K0ILV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59702">
        <property type="protein sequence ID" value="AFU59702"/>
        <property type="gene ID" value="Ngar_c27810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27810"/>
    <dbReference type="HOGENOM" id="CLU_189635_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2781-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10288" checksum="7FB7FBC62CC9622B" modified="2012-11-28" version="1">MTLFPNDDIITQIIGSWQSYADVLNAEDRIAFDNMMKKCYKYSRSIEAKAKPFENEALFMAMLLEQEKIILWLLAKIEKLEKGKVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM14</accession>
    <name>K0IM14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59882">
        <property type="protein sequence ID" value="AFU59882"/>
        <property type="gene ID" value="Ngar_c29640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29640"/>
    <dbReference type="HOGENOM" id="CLU_3021095_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2964-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="5717" checksum="07115EE7414107D1" modified="2012-11-28" version="1">MAIAAAILLGSVAAVSGLGKATTEIASTDDDQRDVLADIFALQYADAAQVDYFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM37</accession>
    <name>K0IM37_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amtA</name>
        <name evidence="10" type="ordered locus">Ngar_c30510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30510"/>
    <dbReference type="EnsemblBacteria" id="AFU59967">
        <property type="protein sequence ID" value="AFU59967"/>
        <property type="gene ID" value="Ngar_c30510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3020"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_2"/>
    <dbReference type="OMA" id="PHNVPFI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="10"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="408" mass="43059" checksum="C49418AB88E3098D" modified="2012-11-28" version="1">MPIDTGDTTWMLISTGLVMMMTPALGFFEAGLIRAKNSLSVIMQTFSGLAILSILWFVIGFTLVFAPSQGGFIGGLDWLFFNNVPFNDSLDYAPTIPGVTFASYQMMFAVITPLLITGAFAERMKWSSFFVFIIAWSILVYYPLAHWIWGRGWLADMGVFDFAGGIVIHTSAGLGSLAAALVLGRRKNFGPDIMVPHNIPLAVIGATLLWIGWFGFNAGSVLASGALAANTLLVTHIGSATSAMVWILLSWKRSGKPSTTAVINGAIAGLAGVTPAAGFISAQNSFILGIALGLASYYAILLLKEHWKIDDALDVSSVHGVTGIVGSLAIGLVASTLINPAGPDGLLYGNPMQLAIQALGVAVAAALGFGGTVVIMKVINATIGLKVREEEEDIGLDVTQHAERAYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM43</accession>
    <name>K0IM43_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57544">
        <property type="protein sequence ID" value="AFU57544"/>
        <property type="gene ID" value="Ngar_c06010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06010"/>
    <dbReference type="HOGENOM" id="CLU_1369566_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-599-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="23462" checksum="08D1CFEABF59043E" modified="2012-11-28" version="1">MMQRSIINFLTDVSGEEVQKVSTLVDTANDTIDRYFGIVTTFDVLICRGSWEMEVQIISRRKEASDGSIYSDTKFVGMTDYRLQEIVIRYDIAKYGHYLHELIHGVISKSHTHQLREGLAWYFTLKLTEDYRYVRPSYPSWVDEMYVYPIKRLAEIVGEEFLKDFAIGRASLDHETLPKDVQELFLPEEIFYAEKRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM52</accession>
    <name>K0IM52_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57564">
        <property type="protein sequence ID" value="AFU57564"/>
        <property type="gene ID" value="Ngar_c06210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06210"/>
    <dbReference type="HOGENOM" id="CLU_2784235_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-619-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7454" checksum="C7871DD798DEA140" modified="2012-11-28" version="1">MEPTTDENQVKQMQLVLSADSITLHASLMPGVLTTQTFEGTDCYAKFINFLKHVSANGIPISAEITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA2</accession>
    <name>K0IMA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32210"/>
    <dbReference type="EnsemblBacteria" id="AFU60137">
        <property type="protein sequence ID" value="AFU60137"/>
        <property type="gene ID" value="Ngar_c32210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32210"/>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OMA" id="YLKAMLG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3221-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="237"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="429" mass="48070" checksum="1EBD4E25BC7D1387" modified="2012-11-28" version="1">MPKFYCKNKLKVKVLGAAKEVGRSGFLVNCDHTNILMDYGVLLKREPIFPMHVKPKEVDAVVITHAHLDHSGFVPSLYLSGTSDIPALGTLPTFELSELLIEDMIKLSGFYLPFEYIDVMTMLKSSENLQYREPYMVNDAKVTLHESGHVVGGATVVVEHDGKKVFYTGDINTRGSKLLRPADLDFGEIDMMIIESTYSQTEQQPREEAEKDLIEYANDIVERGGTLFIPSFSVERAQEIACVLKAYNFKHKVVMDGMALKANQIMSRHQAFLRDPDMFKRAIGEAEWVQGWSRRKKVVNEPCAIISPAGMLVGGSAIFYTQQIAQSEKNGIALVSYQGEGTPGRMLLDKRVANFDGKITKCYADVRRFEFSGHNSRSELFEILDRVKGNPKVLTVHGDGPSCIKFAEEIREKYGYDAHAPDQGEVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC2</accession>
    <name>K0IMC2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08170"/>
    <dbReference type="EnsemblBacteria" id="AFU57759">
        <property type="protein sequence ID" value="AFU57759"/>
        <property type="gene ID" value="Ngar_c08170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08170"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.783"/>
    <dbReference type="HOGENOM" id="CLU_358888_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-815-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="780" mass="83068" checksum="824D4922C4791E00" modified="2012-11-28" version="1">MKSHANRLGLISFISATLVILATAQPNLVVLSSQQPANVEIAGVFNIIYDDKPQYILTDNSGKSYSLDLDENLTEEQGGPLKLNRKDVVVSGILDPVTNTIKVIAIELANEHDLASNNTSSQNLTEVKVTGVLNTIWPLMAPNDTGDHTIEPKYYLVDNSGKSYSLDLDENLTEEQGGPLKLNRKDVVVSGILDPVTNTIKVIAIELADSPPVGVHRPTSSHLLGAHVSGPQKWAVILCRFGDATSVTPQPTTYFQNEMNFLDGYWRELSYDIINLGGSQVFGWYNLPNPRSTYIPAGGSADLVSLANDCTAAADPDVFFPDYMGIILAFNQDLDCCSWGGSLGLNRDGSVISYSMTWMATWGWSNANVMGHEMGHGFGLPHSSGSYGATYDSRWDVMSSWPTCPPAHPNFGCVGVHTIAFHKDALGWISGAQRYVATTAPDQSVYIERLALPATSGYMVAQIPIGGSTTNFYTIEARKLVGFDDNVPSNAIVIHKVDTTRGDRLAQVVDEDVSPNTNPNDAGAMWVSGEIFRDSANNIAVEVVEETATGFRIIINPSNHPPVANDQSVDTNQNTPISITLSATDPDGDPIAYSIVTNPSQGNLNMFNPSTGTVTYVPTASYFGPDSFTFKATDSRGADSNIATVSIMIKGPPDCNNPTIVGNDNRNDIIQGTTGNDVIDGLGGNDIINGNGGNDEICGGNGNDTINSRGDNDRINGGSGNDIINSHGGNDQLYGGESNDIINSGAGNDLIDGGSDNDIGNAGPGTDKCFNIETAANCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG1</accession>
    <name>K0IMG1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c33320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33320"/>
    <dbReference type="EnsemblBacteria" id="AFU60247">
        <property type="protein sequence ID" value="AFU60247"/>
        <property type="gene ID" value="Ngar_c33320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33320"/>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3332-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="349"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="568" mass="64377" checksum="8ACC0A0C0BC5529A" modified="2012-11-28" version="1">MESAKRWIDSEDAERTEVLHNFEDILACALGILQKIVKSHDLCLDPWGPSAVLGTEDVKNVFVAVHDRGAKIRLITEITVANIQYCKEFMKFADVRHLDKVKGNFSISDTKWYTASAVAERDKPPPYLIYSTVKEIAEQHQYLFETLWNKALPAEQRIREIEEGIESTNLEFISNPSESIKRAWGLIRAAKHEVMVMFSSPNAFRRQLAMGGMEVLQEAAKNGVRIELLVPSDRDVAQTLGHVRSALPQAEFQAMDASLTTSITIVLVDHEKCMIFELKDDSATNSRQAVGLALYSDSRSIVTFYAAILEAIWKQSELNEQIRQANEKLEDAYKRLEAHENAQKEFINVAAHELRTPVQPLLGITELIQNAMDGKEKGEITKEELEMLVRNAKRLERLSSDILEVSRIESQSLKLNKERMDMNQKIQNVIKDVKLLIPSHKHIEIIFEPKAEPIVVEADKPRIFEVLSNILRNAIKFTEEGTIRVTLEESDGQAVVQIRDTGRGIDPEIFPRLFTKFASKSEQGTGLGLYLSKRIIEAHGGKIWAENNKDDRGATFTFTLPLSTKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI4</accession>
    <name>K0IMI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA protection protein DPS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57919">
        <property type="protein sequence ID" value="AFU57919"/>
        <property type="gene ID" value="Ngar_c09770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09770"/>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="OMA" id="TFYYYTI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-975-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01052">
        <property type="entry name" value="DPSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033921">
        <property type="entry name" value="DPSL_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="22836" checksum="26B2EFE77B4BD088" modified="2012-11-28" version="1">MTDDIDYAKTSKPHPNIVAIEVLKKNGVDVDKLIKLITAGVGAEFTTYYYYTILRMHCTGLEGEGIKEIVEDARIEDRNHFEAMVPRLYELGGALPRDIRKFADQAGCPDAYLPENWEDINSILKVLLAAEQCAIRSWGEVCDMTAGKDPRTYDIAQRIMQEEVEHEAWFIELLSKRPSGHFRRKFAGQSPHTGAQGSLIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV5</accession>
    <name>K0IMV5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58284">
        <property type="protein sequence ID" value="AFU58284"/>
        <property type="gene ID" value="Ngar_c13460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13460"/>
    <dbReference type="HOGENOM" id="CLU_2127913_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1344-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="13257" checksum="2717D429A800CDD3" modified="2012-11-28" version="1">MWLLSGVTDDEGNYTGVFRRGARGTIDIIADILLLCTTWNKRTRIMYKANLSHQMLKVYVWHLVELGLLEESEDMKFRTTEKGKVFLSHYQHLSRLLIGLNDHHRPFVPQQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV7</accession>
    <name>K0IMV7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58294">
        <property type="protein sequence ID" value="AFU58294"/>
        <property type="gene ID" value="Ngar_c13560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13560"/>
    <dbReference type="HOGENOM" id="CLU_2519875_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1354-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9684" checksum="1AD934E7FC88DE94" modified="2012-11-28" version="1">MSEPPAATIPEEKAPATTSSWKDRKRQKRAEMHSYSCIKCGITWSGRGRYQWALEHALITGHRIKLPRREKRKKGGGLCHRLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY5</accession>
    <name>K0IMY5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58434">
        <property type="protein sequence ID" value="AFU58434"/>
        <property type="gene ID" value="Ngar_c14990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14990"/>
    <dbReference type="HOGENOM" id="CLU_1044338_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1497-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="30173" checksum="D306105DC99D4F2E" modified="2012-11-28" version="1">MSDEASMNILKKHYSYNSDSSSNYDYGFSTNRGNPYILQSIRALLPSGSPSAWLFDEFPDREKMIIVQSLDNMTDAIELGNKFDKVSHITYDIENWERTTRLERENPVTAISNGSHVVHEAGFKYGITPDAPFLLDNYMKINWSEVDFLGMQLQRFSDNITEYSNYAKMISDHVRSQNPETEIFAQLSFRFASSSNMIEAIERTKDYVDGYIVAYLPDPDNDGISDSCISTCTPEDLDAVLKAINSLKSERPPQERTFVNAGTITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ2</accession>
    <name>K0IMZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58469">
        <property type="protein sequence ID" value="AFU58469"/>
        <property type="gene ID" value="Ngar_c15350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15350"/>
    <dbReference type="HOGENOM" id="CLU_2285135_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1533-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="10992" checksum="1D070211C1D97DDC" modified="2012-11-28" version="1">MASADEEIKKRVARKGGEAPHEERGLQAADQETRERVARAGGEASHGGGGGGEGRGFAGMSEEKQRYQEKAAKARTAEETIRFFFHPSFFFAKNTRAAYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN24</accession>
    <name>K0IN24_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c16960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16960"/>
    <dbReference type="EnsemblBacteria" id="AFU58629">
        <property type="protein sequence ID" value="AFU58629"/>
        <property type="gene ID" value="Ngar_c16960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16960"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="IEVTQGH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1694-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="15806" checksum="0CB93B0E4D5E405F" modified="2012-11-28" version="1">MKIDEMDLRLLNLLQKDSSVPLVRMASSLRVTEGTVRNRIKRLRRTGVIRKFTISVDSTAIGQNVVAFILLNAAPGRLADVAKRLSTIDAISEVYETHTYSDMLLKVRAKNSSDLADIIANRIKTVGGVVGTQVITVLNAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN51</accession>
    <name>K0IN51_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18310"/>
    <dbReference type="EnsemblBacteria" id="AFU58764">
        <property type="protein sequence ID" value="AFU58764"/>
        <property type="gene ID" value="Ngar_c18310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18310"/>
    <dbReference type="HOGENOM" id="CLU_2766236_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1829-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7737" checksum="D5F9286FCC7995FB" modified="2012-11-28" version="1">MHTHDTSGTTHIESTTPREYTVGEFLKVRGTDPSMVTRMTVNGNEVADFLNHEMKIGQRIQIEIMTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC7</accession>
    <name>K0INC7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59144">
        <property type="protein sequence ID" value="AFU59144"/>
        <property type="gene ID" value="Ngar_c22140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2195"/>
    <dbReference type="HOGENOM" id="CLU_054330_0_0_2"/>
    <dbReference type="OMA" id="MDDGMMM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2212-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="372" mass="39908" checksum="4FE010EABC62EF99" modified="2012-11-28" version="1">MTNKTVLILVAAAVTIIIAGTAVAIPSFTQTPANTTSLQNISNAELGSVLKLSSASVLMDIPLIKGYENGNEIFFIGTDVSDKDLAAQLTNMTGFKVNHAPLLAQTPLDARGQVYIFENGIEGNGPLGFQLSVTNAKPGDEGYSPLQQVNLIRWTDESATTELKSVEEVMEHEEMGHLVINQTGVIANQPAIQWNGGSLTIREDRDSISDDSPYMGGQVTGIDTENMTVTFVAHRGWGPDGKTIYYIVTDATPEMPGTMMGVPFVAADEKLAATPVAVDLFQFMNGINGTGPMGFQAGIGGANPDDANYSPMWKISFITWKDPFQARVLETQADINKALATGSITLEPAMGGKHVVNCPFFDQQTVFEHMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND9</accession>
    <name>K0IND9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59204">
        <property type="protein sequence ID" value="AFU59204"/>
        <property type="gene ID" value="Ngar_c22740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22740"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2250"/>
    <dbReference type="HOGENOM" id="CLU_1674044_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2272-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="16744" checksum="414FA290E549B43D" modified="2012-11-28" version="1">MFVAIFGGIAVALLGFSVYQNTLATTPVQQNEVRIDFAVFPAQDVIEVTVGQTARIPVMVEAPRGAVCALEMHVLPISERLPEQASIGLDRAMVALSSLDSPVQDIGENHIQRAAGAFLVISIPADAAQGSYDYALEARKATSDNEGQDVGKIFSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS1</accession>
    <name>K0INS1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c29460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13935"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29460"/>
    <dbReference type="EnsemblBacteria" id="AFU59864">
        <property type="protein sequence ID" value="AFU59864"/>
        <property type="gene ID" value="Ngar_c29460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29460"/>
    <dbReference type="HOGENOM" id="CLU_738896_0_0_2"/>
    <dbReference type="OMA" id="CVVDADV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2946-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_P" evidence="6">
        <location>
            <begin position="89"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="356" mass="38219" checksum="307CAC5A10D793A3" modified="2012-11-28" version="1">MIKGPATVTVDGACDVLGSDVSGKTITVRAGKALPFEPRGRCRLRARLGRGGSMWLADPAKAGVSLWRGITQELTDLVGNKKTTVMLVGETDTGKSTLSVYLANVMLNRGLVPCIVDGDIGQGDLAPPTSIGAAVLPRQVTDLRDVDASLFEFVGSTSPAGFDRFVAKKLRSILDRVGPLGDTCIVNTDGYASDGGIQYKLMIASELQPDAIVCIGDNPELLGAFQGGPWQVLHATPSGQASKSRYERASRRLDQFLRYVGSGSHAVELSRIKFVYMDRLFSPSEILRPPIVQLEPENLKRMFVGLGSAGQIVGFGIITGITPHSIFVQTDVGSFDRIYLGNIRLSRDRAVEVRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW8</accession>
    <name>K0INW8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60099">
        <property type="protein sequence ID" value="AFU60099"/>
        <property type="gene ID" value="Ngar_c31830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31830"/>
    <dbReference type="HOGENOM" id="CLU_163107_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3183-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="13613" checksum="741B58524F939069" modified="2012-11-28" version="1">MTAHIAARHFTSYNLIKKGNNLDIFEKVYYMRALVGVAAGIVAGFLIPFDTSNSPVDQGVAVGMTFGIAVVFYFISLGIGRGIAKNVPKDKRRKVAMEGIVPFIFLLLTFMIIVYTALHQSILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP07</accession>
    <name>K0IP07_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">eif6</name>
        <name evidence="4" type="ordered locus">Ngar_c33790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33790"/>
    <dbReference type="EnsemblBacteria" id="AFU60294">
        <property type="protein sequence ID" value="AFU60294"/>
        <property type="gene ID" value="Ngar_c33790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33790"/>
    <dbReference type="HOGENOM" id="CLU_071894_1_0_2"/>
    <dbReference type="OMA" id="GEDTTGP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="23382" checksum="815E00F6083D1C59" modified="2012-11-28" version="1">MAIYRYTFYKSPNIGIFVKANDSVVLVPHGFAETKGEKLAEYLQVREAHASIAGTRLLGPMSVMNNNGILLPSIASDEEMESIRQATQLKVERANSKFTAIGNLVAANDNGAVASPLLKGELDHQLRDVLGVPAHTMAIGGFVQTGSMITATNVGAGVTPRATEEEVRMVSEVLQVPAEPVTVNGGMPFPSSGIVANSKSVIVGTLTSGPELIMMSRVFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP48</accession>
    <name>K0IP48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60499">
        <property type="protein sequence ID" value="AFU60499"/>
        <property type="gene ID" value="Ngar_c35860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35860"/>
    <dbReference type="HOGENOM" id="CLU_2366315_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3587-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="11204" checksum="BAAEA0014E14CE33" modified="2012-11-28" version="1">MSEEKKYPVSQTFTVLDGYDIYRSNNIIVALVVVQSQFGKDLRLYRWLKKKDQWKVDLCRMGVGRWKWNEIAAKANEFIEKYGIKGSQVAAAEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6U1</accession>
    <name>K0I6U1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56971">
        <property type="protein sequence ID" value="AFU56971"/>
        <property type="gene ID" value="Ngar_c00210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00210"/>
    <dbReference type="HOGENOM" id="CLU_3056955_0_0_2"/>
    <dbReference type="OMA" id="ITIMRMI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-21-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="5733" checksum="0FAC11B547321331" modified="2012-11-28" version="1">MLSADVVCGKCGSVVYKMRMLKSVKDALRATNNRCPVCGAALNPGDFTVAVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7I1</accession>
    <name>K0I7I1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57191">
        <property type="protein sequence ID" value="AFU57191"/>
        <property type="gene ID" value="Ngar_c02430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02430"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-243-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9650" checksum="D7D07EDC5392D7F7" modified="2012-11-28" version="1">MCMINMSRAFVFLNCDIGAGPEIINEMKTIAGVSDAVQVSGIYDIVAKVTEESKENIVMLVKKIRRIDNVRSSLTMIVAEDSKSLAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7I6</accession>
    <name>K0I7I6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP--cobalamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c02530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02530"/>
    <dbReference type="EnsemblBacteria" id="AFU57201">
        <property type="protein sequence ID" value="AFU57201"/>
        <property type="gene ID" value="Ngar_c02530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02530"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.247"/>
    <dbReference type="HOGENOM" id="CLU_083486_0_2_2"/>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-253-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="186" mass="20233" checksum="C5ABB79D12566EB0" modified="2012-11-28" version="1">MKIYTKTGDKGETGLIGGKRVSKADPRIIAYGAVDELNSSIGLAVSFLRPRKEFSDLVDVLVQVQNDLFIVGSDLADPSFPKAANNTTPRADEKMASALEPVIDRFELELEPITFFILPGGSVEASLLHQARGVARRAETAIVSLSKSQTINPAIVVYLNRLSDLIFVAARLANKRLGVPDIAWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7N2</accession>
    <name>K0I7N2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like monooxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03080"/>
    <dbReference type="EnsemblBacteria" id="AFU57256">
        <property type="protein sequence ID" value="AFU57256"/>
        <property type="gene ID" value="Ngar_c03080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03080"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.299"/>
    <dbReference type="HOGENOM" id="CLU_027853_5_3_2"/>
    <dbReference type="OMA" id="HHANVIR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-308-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="40859" checksum="75476CB55A5568B7" modified="2012-11-28" version="1">MKVKFGFTQGLNVARLGLDEQQIMTAAQMADRLGYDSIWAMDHSNVPQWKNAIVNDAWLMLAALGAITRNVELGTCVTDAIRRHPSAIALSAITLDRITLGRGILGIGAGEAQNVVDFGIEFSKPVTKFKEQLEVIERLFESDPDHRVNYNGQYYKLINACLQAKSIRKPRPPVYIAAGAPKTLELCATYGDGWIPIGYTPELFKHHANVIRNHAKELGRDLSNFQFANDVDVYFTDDGEEAWNKMKNAVKVSLFKPELLKVHNIEQDSEFDFRKYFTEYAMNKPELMEQMKRAAMKIPDSVARTAIGVGKPDDVIQMLERFIKAGTNHFIIRFWGEGYFRSIEQFGNKVIPYFREQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Z7</accession>
    <name>K0I8Z7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57741">
        <property type="protein sequence ID" value="AFU57741"/>
        <property type="gene ID" value="Ngar_c07990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07990"/>
    <dbReference type="HOGENOM" id="CLU_3227951_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-797-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="43" mass="4816" checksum="0B54A4F1566B51D6" modified="2012-11-28" version="1">MLQSGGYSRLDDSTRGLMESRFGCDFGSVRIYAEMLQLGQPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0I902</accession>
    <name>K0I902_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57751">
        <property type="protein sequence ID" value="AFU57751"/>
        <property type="gene ID" value="Ngar_c08090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08090"/>
    <dbReference type="HOGENOM" id="CLU_643433_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-807-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="426" mass="46535" checksum="3D0E1D4A8A04EC0A" modified="2012-11-28" version="1">MMVLVIPISAFAESFTVITNKDIYTPDEKAIIVGAIPADAPDGYAVIIKITGPGGECATQNILPAENNSFRSRPVRLDGCGFGEISVSAFYAELNATSTFTISESSSQADAGSRMELRILKNTVLQAQETVNQKVKDLVEGGYVLPEEIAEKYGEGVSQASLALEAIEFGDAAEAKKHIIFALRDFREVLDALSENVARFEQTATDNNPDIVGMYDILQRYYYRLQLVAEKNHVDKEEEFKAAALLLSNIKRMIGEGNYEAAGRNLERVNMILEKIRSTLSEEGESKERLTSETNSTSEVDEELARKLIEIAARYENTVLELLNKTSSDPEAKAKVQEVIALIANARTSIEAGDLESARQNLSAAYHAINYTKKLVEDDEDGNTSASSKGKDSDNDSKESSNDDGEDSKKSGKKGSNRGNSDKEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I928</accession>
    <name>K0I928_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57801">
        <property type="protein sequence ID" value="AFU57801"/>
        <property type="gene ID" value="Ngar_c08590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08590"/>
    <dbReference type="HOGENOM" id="CLU_2313874_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-857-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="10678" checksum="E50D8F0AC32E5F51" modified="2012-11-28" version="1">MDFMLAAAAAAITNIGLLAVIIATYIQNARLIKSYFTYGLILVASLFIVQNIVIVVFWSNLYAAGPAIKNIVDAAAPYLFAINSAQTAGLSILLWISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAR0</accession>
    <name>K0IAR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58421">
        <property type="protein sequence ID" value="AFU58421"/>
        <property type="gene ID" value="Ngar_c14860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14860"/>
    <dbReference type="HOGENOM" id="CLU_3227952_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1484-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="43" mass="4947" checksum="7968856C00214B38" modified="2012-11-28" version="1">MVKIEAHSVRRQNASRAELYLCPICKAEFKEKILLAIHIGTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAY6</accession>
    <name>K0IAY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58501">
        <property type="protein sequence ID" value="AFU58501"/>
        <property type="gene ID" value="Ngar_c15680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15680"/>
    <dbReference type="HOGENOM" id="CLU_2949422_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1566-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6822" checksum="52AE7EBB0F8F1D56" modified="2012-11-28" version="1">MAAVEIDNSKFHAMMEYLRLARAKNEKRISEEQLNGGMTQIEIALMDNIIRRVNDAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAZ1</accession>
    <name>K0IAZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58506">
        <property type="protein sequence ID" value="AFU58506"/>
        <property type="gene ID" value="Ngar_c15730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15730"/>
    <dbReference type="HOGENOM" id="CLU_1682753_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1571-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="16366" checksum="9BB3D375A6450493" modified="2012-11-28" version="1">MGLISAITALIGGFAGALTGSSFSFSDPKTGESVVVQSSGYSWARMINDRLTTTAQTLAQGASLKFKNETQRPMRVLYVSLVPDSAFKTKGHVQVLINDISVFLPNKPAYFTDIGSKTIDFGNVGMTLPAGKDIIIQTASSDGTSVTLTAAVVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBX2</accession>
    <name>K0IBX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58796">
        <property type="protein sequence ID" value="AFU58796"/>
        <property type="gene ID" value="Ngar_c18640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18640"/>
    <dbReference type="HOGENOM" id="CLU_2695894_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1862-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8604" checksum="DC76946735A1D628" modified="2012-11-28" version="1">MVRFELARDEFNRLILEIFVAEDQQPPVLLDDPTIHETLRQCVLIRAINDRTGDLIAEFAKVERWQRRDAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBX5</accession>
    <name>K0IBX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c18690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18690"/>
    <dbReference type="EnsemblBacteria" id="AFU58801">
        <property type="protein sequence ID" value="AFU58801"/>
        <property type="gene ID" value="Ngar_c18690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18690"/>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_2"/>
    <dbReference type="OMA" id="TINQIMW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1867-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="287" mass="31055" checksum="75D40A8D286DAFFE" modified="2012-11-28" version="1">MGQVSGSVVATADGIDSLSDAMISLIVLVGLRMAHKPADRKFPFGYHKVESFAALIAAIGMVAIGGFILYHSYEALLHPRVIQQPVLTMIVLAAAGAVSLHRAFQMNSIANRYNLLSLKTDAKNSIKDGSASIIGFVSVLIASQFGFLQMDAIGGIIIAGYIFSVSYISLKQSSLILVDSWQNPRITEMVKRIVEEKFKDENIRVKSVLLRPAGALAQAEVHLEIDGNKRLADVELLLVNIEAAIRSQIPVIGRISSIPHSYPAQRSEPTRRFGGIFGDRRNTSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBZ5</accession>
    <name>K0IBZ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58841">
        <property type="protein sequence ID" value="AFU58841"/>
        <property type="gene ID" value="Ngar_c19090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19090"/>
    <dbReference type="HOGENOM" id="CLU_211278_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1907-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6459" checksum="AC80B74D9E01BF2A" modified="2012-11-28" version="1">MGSRRRKTLARPARKSRRVDGRCPKCTTIVKFNVSGPVGDEIYECTGCMSKFHIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC12</accession>
    <name>K0IC12_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58876">
        <property type="protein sequence ID" value="AFU58876"/>
        <property type="gene ID" value="Ngar_c19440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19440"/>
    <dbReference type="HOGENOM" id="CLU_1036718_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1942-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="268" mass="30414" checksum="32A073ADDC904F28" modified="2012-11-28" version="1">MEIEVFSLYKRFTNIFKLDVQGGSIYESYVADENTHFHRGKYYTHVKTPAKVEHVHPDVVTSLVRKAFTQKLIASGYTVDFETAFQSREDEIRNNAFSDIVQVFNGFRFRILGSSNRIYMICDPHLVIRSKASVGHILSLGVPIAILTGVKVSELSSSKTIGYIKEQNFQGGKIRIQKFDKPGPEDVEPNSISIEPRPEVIHNILSYAGRNVDFITLQRQKSLLDSKTASRDRFSQTLLTVDKLRKIFPLIFGDFTVNLAKDPLVVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC55</accession>
    <name>K0IC55_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small-conductance mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mscS1</name>
        <name evidence="2" type="ordered locus">Ngar_c01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01760"/>
    <dbReference type="EnsemblBacteria" id="AFU57125">
        <property type="protein sequence ID" value="AFU57125"/>
        <property type="gene ID" value="Ngar_c01760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01760"/>
    <dbReference type="HOGENOM" id="CLU_808023_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="343" mass="37853" checksum="6FD75998EF45BB7A" modified="2012-11-28" version="1">MVTTIDQLVILMQENNILFSILVIGGTVLGIKLLGFVFQKIVNALDRHEHLRQLDSRLIYAIRIPLYLGVALTGLRIALTQVPFLDSYSSILDQIFYVGSLVLIAAIILKVIDVIGLVTSRSWFKRTRANVSSLILPMSRLGKGLTVFLIGAAALAVFGVDVTDILFGWGLLGFAIVVALQPIILDVFAGLSIASQGSLRVGQRIILSSGELVEVKEIRLQNTLFRDVLTGNIYSISNADLMKQKITILEKGVLPVPIAFKVGYDDVQMAYNIAMQIGTDLRRYLAKDPVVNIRELNDNNKAKLELLLWISDASNKDNVVTQVLTKLINALRRNAIVTEQKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICD9</accession>
    <name>K0ICD9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA amidotransferase subunit C</fullName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="1" type="ordered locus">Ngar_c02720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02720"/>
    <dbReference type="EnsemblBacteria" id="AFU57220">
        <property type="protein sequence ID" value="AFU57220"/>
        <property type="gene ID" value="Ngar_c02720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02720"/>
    <dbReference type="HOGENOM" id="CLU_105899_4_1_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="10425" checksum="C0174C35F69BF947" modified="2012-11-28" version="1">MVTKEEVKHLGWLARIELSDDELDRYTSQIKEIIKYLDKLDTIPLEEVKPIVSRKKFADLRRDEPADFEGDTLGTKYRKDGFVKGPRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICL8</accession>
    <name>K0ICL8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trxA1</name>
        <name evidence="3" type="ordered locus">Ngar_c04230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04230"/>
    <dbReference type="EnsemblBacteria" id="AFU57370">
        <property type="protein sequence ID" value="AFU57370"/>
        <property type="gene ID" value="Ngar_c04230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.404"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_2"/>
    <dbReference type="OMA" id="IQVDVDK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="12494" checksum="10C80255785865DA" modified="2012-11-28" version="1">MAKPTTASNVQDTNPQNFDGIINSNTVTVADFWAEWCGPCKQTEPMFRRVADKYSEKAAFVRVNADENQELVQKHGVMSLPAFLVFKNGQVKESAFGGIGQGKLEGMIQKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICN9</accession>
    <name>K0ICN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57400">
        <property type="protein sequence ID" value="AFU57400"/>
        <property type="gene ID" value="Ngar_c04540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04540"/>
    <dbReference type="HOGENOM" id="CLU_2091194_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-453-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12611" checksum="F043AAAB32ACED7B" modified="2012-11-28" version="1">MAVIGTFIIDFQTTEFEPDGKIAVDLLSGWQKTIQLENAFALDPPVQSAGWSFAKMFLAGQFVEKIYTAYAYDINASKGKKFEDKFIAWLQKELKNRGCGAQIKMAPEMKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICT3</accession>
    <name>K0ICT3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57465">
        <property type="protein sequence ID" value="AFU57465"/>
        <property type="gene ID" value="Ngar_c05220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05220"/>
    <dbReference type="HOGENOM" id="CLU_3075467_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-520-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5896" checksum="BAA4C070CDF6C535" modified="2012-11-28" version="1">MAAICIGDRIQCKDGVEGTVTDFHKYGNEHHIVIKTDKGEERDLKLSDYCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID59</accession>
    <name>K0ID59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59321">
        <property type="protein sequence ID" value="AFU59321"/>
        <property type="gene ID" value="Ngar_c23960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23960"/>
    <dbReference type="HOGENOM" id="CLU_058359_0_0_2"/>
    <dbReference type="OMA" id="YENDEFR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2394-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="291" mass="33149" checksum="4BD918504682BDA1" modified="2012-11-28" version="1">MPLLAVRAPFKGEDYFCRRVNAAAQKVEQTYLEAIGPAIAMRQTNAMLGDGTVTQADTFDPQNVQVFYQRLANSLKGWAFTGILKSANEDLHRLYCQFTKEAGKYYISGYFGVQFHVLPYYRVDRRVIEVQKELAKIADDATSLFKDMTGAADKALAAELEKRGYGNLEFQELFTKIFDDEKLVQELDEKAAAVEKQFPEFEKMGKRKTELFAELNDLLIELYQTSPVLIDYNRLMHGEEGVTNYFDIEVIKNKKTREAHLDTPKIKKDYADLIAGELDKVADALKKAKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID88</accession>
    <name>K0ID88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rieske (2Fe-2S) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c24320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24320"/>
    <dbReference type="EnsemblBacteria" id="AFU59356">
        <property type="protein sequence ID" value="AFU59356"/>
        <property type="gene ID" value="Ngar_c24320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24320"/>
    <dbReference type="HOGENOM" id="CLU_055690_5_2_2"/>
    <dbReference type="OMA" id="ICSHEEW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2430-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="10963" checksum="1A6A885B02028FD1" modified="2012-11-28" version="1">MAKVLVGKASEIGEGKMTHVTAGGKEILVANIGGNYYATGNICNHAGAELHEGELNGKELTCPWHGAKWDVTTGSMIWFPQKLKDLGKYKVTVENGTVYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDX5</accession>
    <name>K0IDX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flagella assembly protein FlaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flaJ</name>
        <name evidence="2" type="ordered locus">Ngar_c10130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10130"/>
    <dbReference type="EnsemblBacteria" id="AFU57955">
        <property type="protein sequence ID" value="AFU57955"/>
        <property type="gene ID" value="Ngar_c10130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10130"/>
    <dbReference type="HOGENOM" id="CLU_036985_0_0_2"/>
    <dbReference type="OMA" id="DRLWHTG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="526" mass="57183" checksum="E0372B7C72C387B8" modified="2012-11-28" version="1">MIKYMEALQLLGLRKTTTAVTEDPSQPGVKTKGSFVPKRVDETIVYFSLLLFGISTGQIQPSDLIKTSGNTKQYGYYSQIFAKIHLLGVKWQYGLAKACELVAAEIKAEEFKLLLMKLAQVLRLGEDLSTFLSQELQAVMHGYITTYERAMRSLDMLLEMYSTMMSTSSFLVASMALLTMISGGGDSSQLVVIVTLTILMGLASFVFMAYYLFPKDRIMIKEGHSDMVKIKKMLMMALGTAASIGISLSFLNILPIPLVIAIAGVPLILPGLLARKLDAKIRKLDDSYPSFARHLGDVYSTVGSLGQSLKSVLRSDFGILNTHIESMTNRVMSRIKIEDAFDLFSKDTGSVLISAGNDVMSNALVKGANMLQVGSRLSEITTKFLEIRKKRLQSAKAFESTIIIMHVLTLAVFSLINRLLNFLAQYFALQQSVGSEGAAILSIAAGDTTLMSMILSLLIVALSGVNAMALKVSQGGLFHTIWFNMGVLLGIGGVVVYGVDIFLDSMIGDILDITESLEASAGLGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE45</accession>
    <name>K0IE45_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">coaBC</name>
        <name evidence="6" type="ordered locus">Ngar_c11030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11030"/>
    <dbReference type="EnsemblBacteria" id="AFU58045">
        <property type="protein sequence ID" value="AFU58045"/>
        <property type="gene ID" value="Ngar_c11030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1045"/>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_2"/>
    <dbReference type="OMA" id="LDMIVAN"/>
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    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="198"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="203"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="420" mass="45533" checksum="A7B99BFA9B096609" modified="2012-11-28" version="1">MRVKRGSHPSKDIVGSDGNELGGKKIVLCITGSVAAYRAIDLARLLMRHGADVHAVMTESTASTLLHLEMMKWATGNDVVTKLTGNLEHVMLADYGMSDLIIVYPCTANTLGKMVAGIDDTPVTSVLSVALGSKIPIIIAPAMHEAMYENKFIRQNIDRLRGHITFVEPTMEEGKAKVAEPRQVLDAAVAILSGGRPLAGKRVLVTAGSTVEHIDPIRIVTNTSSGKMGIAIAHEAERMGADVTLVYGHGSEPADEKAVRVNTSEEMYRAVISELSSKKYDIAIMAAAVADFTPARKSEKKLDTRAGRMELSLVATRKIIDEVKKRSKGTFLVAFKADYDVPDSVLVEKAYKKLHESDADIVVANDLGRKGSEAGSDKNQVFIVDKKKRVVHLRLESKQAIARKLLELVAQSVNGKDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEI8</accession>
    <name>K0IEI8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59761">
        <property type="protein sequence ID" value="AFU59761"/>
        <property type="gene ID" value="Ngar_c28410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28410"/>
    <dbReference type="HOGENOM" id="CLU_2662488_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2841-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8270" checksum="8C4C3686B8D95E24" modified="2012-11-28" version="1">MVIECSAGEGKKKKFSFRLNYGDEDDSDSKGYCCAGSSAGGRMWLSQNLPFLVFMLTGFLVVILSGDMLLRVLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEU3</accession>
    <name>K0IEU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59876">
        <property type="protein sequence ID" value="AFU59876"/>
        <property type="gene ID" value="Ngar_c29580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29580"/>
    <dbReference type="HOGENOM" id="CLU_2821043_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2958-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="8036" checksum="7C7C177479F18911" modified="2012-11-28" version="1">MHMADLTDRQHYCKYCSKEFKPERSTRRYCSDGCRIKMWYKRNGRSRRNRKSSSSGRKAKQKKQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEY2</accession>
    <name>K0IEY2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c13930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13930"/>
    <dbReference type="REBASE" id="55357">
        <property type="entry name" value="M.Nga92ORF13930P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58330">
        <property type="protein sequence ID" value="AFU58330"/>
        <property type="gene ID" value="Ngar_c13930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13930"/>
    <dbReference type="HOGENOM" id="CLU_063430_0_0_2"/>
    <dbReference type="OMA" id="MNRHGFN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1391-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="32466" checksum="40286970C41AA9AB" modified="2012-11-28" version="1">MQAVKSQIGLKEAAPFVKWAGGKTQLLPILDAHIPQFVRYFEPFLGGGALFFHLASRLQFSAHLSDANRELVNAYNMVKRDVEGLIGLLEKHEKNYKRAPAEYYYQLRSARPDGDMKSAARFIALNKTCYNGLYRVNRSGEFNVPIGRYSNPAVCDRDQLRRASIALNYSDAKIVACDYKHALKKAREGDFVYLDPPFNPLSETAHFVDYTKNGFGKEDQIELAQVFRELDNKGCKVLLSNSDTKLTRELYSGFDQSRVRVLRAISCKGSRRTGYWELLIRNYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF07</accession>
    <name>K0IF07_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30250"/>
    <dbReference type="EnsemblBacteria" id="AFU59941">
        <property type="protein sequence ID" value="AFU59941"/>
        <property type="gene ID" value="Ngar_c30250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30250"/>
    <dbReference type="HOGENOM" id="CLU_2519881_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3025-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9594" checksum="A2D3534F99F52BFA" modified="2012-11-28" version="1">MSSVAVEYYNRKFGENRSAAFIHLVREIGEIAFAMEKNNVEHAKIEITESAALLYYLATKYSLDIDANIKAVYSKKLEMLKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF33</accession>
    <name>K0IF33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative diphthine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c14540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14540"/>
    <dbReference type="EnsemblBacteria" id="AFU58390">
        <property type="protein sequence ID" value="AFU58390"/>
        <property type="gene ID" value="Ngar_c14540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14540"/>
    <dbReference type="HOGENOM" id="CLU_066040_0_0_2"/>
    <dbReference type="OMA" id="CTGLEMY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1452-MON"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF357" evidence="7">
        <location>
            <begin position="278"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="357" mass="39284" checksum="B7EF5A136D8E174B" modified="2012-11-28" version="1">MLWFVGTGINGYRGLSLAAVDILKKCSVVYVERFTSALSDSDLQGLNSILGRQAEPVQRWFVEDGREILEVAKTKEVALVTYGDPLIATTHTELRSRAARNLIKTGVLHAASGIASIMGETGLHAYKFGRMVTMMSEPQSVVSVYNTIFENLLAGSHTLILTEYSSQGKGKEEPFFLSPTSVFKMLLDTERDQKYQIFSDNTFAVVASRVGAGDQRITSGKVGSLAKIDFGAGPHSIIVTGSLHFTEVEALAALTENMDEPSDNSQNIRRISVQMVERYAPKAKQAIQQMRDIVRQDAGNNSGVFEVLDNAEYYIADAERFLRQAKFELAVLSIGYAEGLVDALRFQKGINPWETHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF40</accession>
    <name>K0IF40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57423">
        <property type="protein sequence ID" value="AFU57423"/>
        <property type="gene ID" value="Ngar_c04790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04790"/>
    <dbReference type="HOGENOM" id="CLU_2930305_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-477-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6783" checksum="9F68C9575EDA305F" modified="2012-11-28" version="1">MTYKITVKINEKNLSTEAIKQAVNYISGALDSMQIAHTIECHKDKIVLTRMSKPPTIVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF59</accession>
    <name>K0IF59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60001">
        <property type="protein sequence ID" value="AFU60001"/>
        <property type="gene ID" value="Ngar_c30850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30850"/>
    <dbReference type="HOGENOM" id="CLU_2032934_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3085-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="14159" checksum="F1BC31AF1B2DB584" modified="2012-11-28" version="1">MTKKMAKASRSAVKTLTLVKSRDIVVDKLLKPCEEGNHSKCTGWAVLRREVSPIDANYFLKCTCACHHQKKKERKKVVRKQQHQQIRKKLLKKKIKKKAKKKQQKAVVARKSKRSKKARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF80</accession>
    <name>K0IF80_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58450">
        <property type="protein sequence ID" value="AFU58450"/>
        <property type="gene ID" value="Ngar_c15150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15150"/>
    <dbReference type="HOGENOM" id="CLU_123710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1513-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="12046" checksum="0C80CA0DEE75D77E" modified="2012-11-28" version="1">MSSDPRLVIANVLAGAALALVTVYVIAGMQTMLPANVVGISTLVMSVGAFVLSLKKRSYSVSVMLSANGIIHAVSAAIVLGDSAGASSGIIIAFIFGLGTIGLGVAKGIETTRIAATAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF88</accession>
    <name>K0IF88_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">valS</name>
        <name evidence="10" type="ordered locus">Ngar_c31150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31150"/>
    <dbReference type="EnsemblBacteria" id="AFU60031">
        <property type="protein sequence ID" value="AFU60031"/>
        <property type="gene ID" value="Ngar_c31150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3093"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_2"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="612"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="783" mass="90653" checksum="B9B547B133CFD4B9" modified="2012-11-28" version="1">MEPKIQSTSWNPQIEKTILKKWEEQDIYRFEINDKKPAFVIDTPPPYPSGRPWHIGAAAHYAQIDMIARTARMNGKNVLFPIGIDRNGLPVEIYTEKKHKVRMRQMDREKFLELCRMALDDLEAEMIQIMKGMGLSGNFKEHYRTDSDSYRALTQSTFIELWNRGLVYLANRPNNYCPDCGTTIADAEIIYDEIPTKLVYMKFKIKETGSNIIIASTRPELLFACQAVIVNPEDNRYKSLQGAHAILPLFNREVQIMPHHSVKPEFGSGAVMVCSYGDQNDVQVFRELGLKEIVALNENGFTTDAAGPYAGLRINQARTKIIEDLKNSGLMEKEESIMHRTPLCERSKTPIEIIPLHDYYVKQLDLVPQLRELAHKLKFHPEMHRQVLLNWLDSIAIDWPVSRRRFYGTEIPIWYCNSCKAPNLPPPGKYYRPWKEKPPFDKCEKCGGTEFIGEDRTFDTWMDSSISPLYVTKYGKDKKMFEYAYPTAIRPQAKDIIRTWLHYTMLRCVQLTGRMPWNEAWIMGYGVDEKGEKMSKSKGNVIDPFPVIQKYGADTFRFWSASEANLGYDFRCSEQRIAGSQKFLSKMWNLGRFLSSFEVVEQQPEEELEATDRWMLAELARLVDECKKGYDEYNFFIPANAIRDFTWNLFAAHYVEMVKGRAYATGQNDAAKKSALYTLHRCFSTILLLMAPITPFISEELWTKIYSPASIHLQPMFREEKADDDMAKFTKQITDFNSMVWNKKKETIKEDGKPLSLKDPISIQVPPELAPFAKDLKEMHNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFB0</accession>
    <name>K0IFB0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c31450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31450"/>
    <dbReference type="EnsemblBacteria" id="AFU60061">
        <property type="protein sequence ID" value="AFU60061"/>
        <property type="gene ID" value="Ngar_c31450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3123"/>
    <dbReference type="HOGENOM" id="CLU_036896_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3145-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="355" mass="39343" checksum="7E692F386ABF6135" modified="2012-11-28" version="1">MPDTLKTLSNLGVAKCKVNPAQGILMGWQAMSYLAFAALFAFVIMAAVAPDLSPGLGRFLMFVVFPGTSLVAVIILGANLVTGDYMTSGISLMTGQAKWREVFYQWSITHAGHWISGVVIGWMIIVGALMLAGPGYGEAFTNFLVNVGNLKVNVLTWDQLFWRAIFANWMVTMAVWGAFRTQEVIAKILLISFPLGTFFATGFEHSIVNHWVLSAAIWQGADYTWGQAMWNNLVPVTLGNIIGATFFMGMVYWYTGGMQKWLAADKWRQPHGTYRDLARAFKDAITLMIAFTAIMPAAIGAILLFGLEPAMGIQPGTNNPNWIEPIIVIGWFVGISLIVKWFLWPRRPWYKIPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFD6</accession>
    <name>K0IFD6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58525">
        <property type="protein sequence ID" value="AFU58525"/>
        <property type="gene ID" value="Ngar_c15920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15920"/>
    <dbReference type="HOGENOM" id="CLU_1943958_0_0_2"/>
    <dbReference type="OMA" id="QYTALIC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1590-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="13234" checksum="BE9F026CD9DB4911" modified="2012-11-28" version="1">MRLAFIVAAAVGIVAVALIAMFASALPTKDYDLSVDALKDEQSLYTNSRVIVKNIGRLPLTNVLVDYGGGQKEPVIPVLQPGKTMNFSPPEGVQLDRVTVTAEPGIEIVQPYRSPIKLPGMIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFI7</accession>
    <name>K0IFI7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC efflux transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c06500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06500"/>
    <dbReference type="EnsemblBacteria" id="AFU57593">
        <property type="protein sequence ID" value="AFU57593"/>
        <property type="gene ID" value="Ngar_c06500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06500"/>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="OMA" id="IAQSAMF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-648-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="13"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="259" mass="27972" checksum="D5886D994A912325" modified="2012-11-28" version="1">MQSTISIEDHLTKIYALWLREFKVFMREKSRLVASTFTPILWLFVIGSGLGATNPSTVPGVDYQQFIFPGIVAMSIIFSSVFFGSYIIWDRKFDFLKSVMVAPVSRGSVFVGKTLGGMTTSLIQAAILLAIGAAIGIPLTPLSLAQDIAIILLMSFGLTSLGLALGSYMYSLEGFQMIVSFVVFPLFFLSGALFPLDNLPSWLGVLTAADPATYGVDALRHAMLGVGTNSMELDMAILVAYTAALGAFGIFSFNRMKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFJ6</accession>
    <name>K0IFJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="3">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pgsA</name>
        <name evidence="3" type="ordered locus">Ngar_c16520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16520"/>
    <dbReference type="EnsemblBacteria" id="AFU58585">
        <property type="protein sequence ID" value="AFU58585"/>
        <property type="gene ID" value="Ngar_c16520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1628"/>
    <dbReference type="HOGENOM" id="CLU_080384_1_2_2"/>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="19693" checksum="5A733595B7844D41" modified="2012-11-28" version="1">MSANFWTGVGLAISIAAGVAYASPAFLDVRWYSPYLAAVIGGVLLLVSAFFDVVDGSVARVTKQTSKKGAFLDSSFDKISEVVIFAGIAFGSLADPFWCLVALGVSILVSYTRARAESLGVELKGIGIGERAERILILAIIGMIPLDLISGMHSGMYWAVIIVSIVAGITLIQRVAVTAKKLSSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFL6</accession>
    <name>K0IFL6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glyceraldehyde-3-phosphate dehydrogenase, phosphorylating</fullName>
            <ecNumber evidence="5">1.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gap</name>
        <name evidence="5" type="ordered locus">Ngar_c16720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.59" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16720"/>
    <dbReference type="EnsemblBacteria" id="AFU58605">
        <property type="protein sequence ID" value="AFU58605"/>
        <property type="gene ID" value="Ngar_c16720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16720"/>
    <dbReference type="HOGENOM" id="CLU_069533_0_0_2"/>
    <dbReference type="OMA" id="NAIVPNP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043891">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="349" mass="39707" checksum="852E3E11D999B3A5" modified="2012-11-28" version="1">MVLVRVFINGYGNIGRRLASALSVDKEIQFIGVAKYTVDDKVKEALDNHYNVFVPKEMIGAFKDKGYNVTGAVEEAVKQSDIVVDAAKEGGGYDNKKSLYEPMNKPAIFQGGEDRHGEHAVADMIHNSRVNYSKAAGKTYVIQGSCNVSGMGRIMQPLIEKFGNRIKRYDVELIRRWADLEDTKPVKDSIEWDRNPHHQEDVKDFIPSANLYVDAFKVPSRMMHLHQMFIRFSDRAPTKDEILECFRNEFGVAIISSAKGTGDVRKKALELGFAHGDTNMVHIHQDIIRVQDDVVKIGYSDDQTGMVIPENHMLLQSMVFKRPREEALKRTDNLFQVSKKRKILEEEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFP0</accession>
    <name>K0IFP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative soluble quinoprotein glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57648">
        <property type="protein sequence ID" value="AFU57648"/>
        <property type="gene ID" value="Ngar_c07050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07050"/>
    <dbReference type="HOGENOM" id="CLU_030947_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-703-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="514" mass="55419" checksum="AEFBAF77169FC628" modified="2012-11-28" version="1">MPEGYSAEAVLWNLTLPTSVTFDGNGSMYVAESGYIYGELRPQPKILKVDQNGNVSVFLDRLLSPPVNDIEFNKHNGLLYISHRGMVSTVDSGGVVKNIIVGLPSMGDHHNNEIEFGLDGRVYVTIGVLTNSGVVGPDNALHGWGPLMTKLHDVPGQDITLTGQSFESDNPLTADPNDKATTGAFVPFGNTTEQGQVVKGNVLCNGCVISANPDGSDLQLEAWGLRNPFGLEFNDEGRLFASDNGADERGSRPIKDDDDKFQEIRIDEDKPRFYGWPDFFGNAEPVTDPKFQSPRANGTQLEFLMEDHPEVEKPLALIDHAAAATAVEFAGDEFGLEGKALVGEFGTMAPTTHSPHGEIAKALEGKAIIGQKVIAIDLETGNYTDFISLNTPDPAFRPVGLAYNEDENALYIVTIAKAEIKMETPLGKPLPEPIPWGYPFTGAVWKVTMDDTTTAGGEEVMTTNNQTITTADVTADTPSSATTSANMTGIWPVPNATNNTNTTTTRDDTDDDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFP3</accession>
    <name>K0IFP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TatD-like deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07100"/>
    <dbReference type="EnsemblBacteria" id="AFU57653">
        <property type="protein sequence ID" value="AFU57653"/>
        <property type="gene ID" value="Ngar_c07100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07100"/>
    <dbReference type="HOGENOM" id="CLU_061552_0_0_2"/>
    <dbReference type="OMA" id="HPMGYPK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-708-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005295">
        <property type="entry name" value="UCP005295_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="270" mass="31273" checksum="8689BCF2D5EF8261" modified="2012-11-28" version="1">MTRLFEPHIHMYSRTTDDYDAMSKAGIEVIVQPSFWLGTPRTGVSTFEDYWEHMITFETKRAKDFGIEHFVCISVNPKEAMERPLALDALKAMTKYLDRERVIAVGELGYNLINDLEEEVFVKQMDIAADKDMLMTVHLPHNNKPEGMRRIERILNSENGKRYKRNKILVDHNVEETIGKTLELGMWAGLSVYPVTKLSPERAMSIIKKYGTERIMIHSAADWGVSDPLSVPLVAREMRKAGFSISEIERVTFYNAYEFFRQSPKFTWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFR7</accession>
    <name>K0IFR7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60211">
        <property type="protein sequence ID" value="AFU60211"/>
        <property type="gene ID" value="Ngar_c32960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32960"/>
    <dbReference type="HOGENOM" id="CLU_3338599_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3296-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4191" checksum="64DA08F99274F1B0" modified="2012-11-28" version="1">MLVSSQLAATTTIFFSLSEIKCYCVLAFSYINYSIMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFW2</accession>
    <name>K0IFW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58680">
        <property type="protein sequence ID" value="AFU58680"/>
        <property type="gene ID" value="Ngar_c17470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17470"/>
    <dbReference type="HOGENOM" id="CLU_145812_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1745-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13993" checksum="7733970CA867A3F8" modified="2012-11-28" version="1">MSYDRFIDERLLTSRDALNRLQIKIKLLEIDENARDFSQRFGQRILVKKVLLTIKHTETEEVEEKELDVEEIERRIKKERLFSSSNRWLASTDIKNGYVVASHHLDLLADAIALDIIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFX6</accession>
    <name>K0IFX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57713">
        <property type="protein sequence ID" value="AFU57713"/>
        <property type="gene ID" value="Ngar_c07710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07710"/>
    <dbReference type="HOGENOM" id="CLU_2115555_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-769-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12823" checksum="296F97939D7B1717" modified="2012-11-28" version="1">MACLSSNGRRSARFLNLRVLIFNDVEIIIPLFPASSLLSKHNVMTIYNTMMMIISSIIITLEAVYAYTSGIFVVIVSSMAQRDLFSYPQDHGFCVWLDVYAELSIANYDNDSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG14</accession>
    <name>K0IG14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57748">
        <property type="protein sequence ID" value="AFU57748"/>
        <property type="gene ID" value="Ngar_c08060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08060"/>
    <dbReference type="HOGENOM" id="CLU_204994_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-804-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7486" checksum="BB01BEA8D04CDF21" modified="2012-11-28" version="1">MAIINAKVDDNLVKEFRHVIYEKYGLRKGDFKNALEEAILDYIRKYAAEKAASSGQKEGAAPAAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG87</accession>
    <name>K0IG87_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase, IS605 OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c08910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57833">
        <property type="protein sequence ID" value="AFU57833"/>
        <property type="gene ID" value="Ngar_c08910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.849"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="CRALTGW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-889-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="182"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="295"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="400" mass="46319" checksum="B6DD3977BBB38EEC" modified="2012-11-28" version="1">MIRTYKFRLYPTEEQVKKLEDTIGTCRHLYNDSLGERRVDWDVGFYEQKQLLTLRKQDNKYLKQVHSQVLQDVLLRLDKAYQAFFKKLAKYPKFKRKGKYNSFTYPQYNNGWKIIGDDDNNNKLVLSCIGAIKIKMHREIPVGTLKTCTIVRDVDQWYACITADDDDITTRTVSTSTEYDMSKPLGIDVGLINWLTLSDGNKIQNPLNFEAQAKKIRQLQRNLARKQKGSKNREKARIALAKAWRQVRRCRDDFVHKTSRTIADQGYTLVAFEKLNIANMVKNHHLAQAIMDATWGKLRQYTAYKVEKRGGRVLVVNPGGTSQKCSRCGVEAKEKLDLSVRTFECRSCGLVIDRDLNAAKNIEKLGLEQAHAETEPLLVQRQRISKFQSRKQEAHVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG97</accession>
    <name>K0IG97_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp) ligase</fullName>
            <ecNumber evidence="6">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">D-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspS2</name>
        <name evidence="6" type="synonym">aspS</name>
        <name evidence="8" type="ordered locus">Ngar_c18880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18880"/>
    <dbReference type="EnsemblBacteria" id="AFU58820">
        <property type="protein sequence ID" value="AFU58820"/>
        <property type="gene ID" value="Ngar_c18880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1872"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="135"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA discrimination" evidence="6">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="429" mass="48058" checksum="4401FDA1EFC3CF84" modified="2012-11-28" version="1">MVNIKRTHYARQLDDQLVGQQVRVGGWIEDVRDIGKLAFVTIRDVTGACQVIVTGDSVQAAVQAPRQSAVVVAGVVQKSKAKDFPVEVKVSEFTVLTKAVHPLPIDPTGRVESAIDKRLDARALDLRTPKVAAIFRLRSAGLVVVRDTLLGEGFIEVNTPKVIGSASEGGANLFSFDYFGKRKAYLAQSPQLYKEQLTLGLDRVFEIGPYFRAENSHTVRHLTEFISVDIEAAFLDYEDVMDIVERVVRNVATAFQEKHKADLQLAGGKDISVSKIDRLTYEQCLDELAKEGEKLQFGDDLSDAALRKLGEIHRGFYFITDWPLKLKPFYIHEKEDNPKLSKSFDLQYGYLELVSGGRRLHDPAKLRSRLAEQGLNPASFEEHLKAFDWGMPPHSGWGLGYDRLMMVLTGSQNVRDVVLYPRDTDRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGE3</accession>
    <name>K0IGE3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35530"/>
    <dbReference type="EnsemblBacteria" id="AFU60466">
        <property type="protein sequence ID" value="AFU60466"/>
        <property type="gene ID" value="Ngar_c35530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35530"/>
    <dbReference type="HOGENOM" id="CLU_631090_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3554-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="434" mass="47673" checksum="3613B91E361CBD43" modified="2012-11-28" version="1">MSIVSSSIDPNYFVGMNAFAENGEEDNSDSTSNNEEDVLIESLGNSSKVTLKIDDDHVNLKVEIEDSDLEDGTYDVMFACNSSNVSKEFLDALDVEEGHGEFATEVALSNGTYMGCEVDVGELSATFASFSVMSDEDDGEDDRGNPEREKHERGEREHKQSSRLETEDEGIEIKVEVEGLNMTDGSYDVVFACQSPNLNRTLDNAFKVEDGKGKFEAEIRLANGTYSGCEVTVGDTVLASFDAFTVSEETEEEQESRVEEKRKEKRERIVIATSGREIHERHRSENAANPGEYELGWNYVLTANGTAMQRNQSGIADRPVATVDINMTVWKSTGAIILLDVLDGTVEIGNQTYTVVLGYALYMIPHDTLRVGALVVDDDGNVYKLKLRGTAEEDDAEFPMESGSIDLTFEGSSGPLNNRLGDWELTLEGTVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGG0</accession>
    <name>K0IGG0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c19580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19580"/>
    <dbReference type="EnsemblBacteria" id="AFU58890">
        <property type="protein sequence ID" value="AFU58890"/>
        <property type="gene ID" value="Ngar_c19580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1938"/>
    <dbReference type="HOGENOM" id="CLU_002513_0_2_2"/>
    <dbReference type="OMA" id="HRAVGNY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1956-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12089">
        <property type="entry name" value="Hef_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041755">
        <property type="entry name" value="Hef_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="354"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="740" mass="84031" checksum="4CD43E4F5FB3377D" modified="2012-11-28" version="1">MTQASFAEHPLVWEGTIDHRLYQKNIADAASHKNTLVILPTALGKTMIAALVCADMLYKYRDKRVLMMAPTRPLVSQHLKSFSAVLKIMEEQVAMVTGKTVPEARRAVWDKRDVRLVFATPEVVRNDLEEGRLHLKDFILLVFDEAHRAVKDYAYTAIAREYVGQSMHPVILAMTASPGAKKERIQEVCNNLYIEHVEYRSEEDGDVKPYVNPIDVKWEWFDLPEEYRYIASVLRSMLDERLKWLVQRGLLGKKKDTRWIFKRDLIEAGEALRYRLELTMEEQRGPIYVAIMNQSAALTLYCLELIESQGAHSLRAFFERIEEEGGRAHAALLKDPKIMEVRALVEKAPVEHPKARRIVELVKEYCCGSSDSSNKQQQKGRVLVFTQYRDTARHIVDDVLSSTGIKASRFVGQAKRQGDEGMNQDEQAAVLQSFREGEFDVLVATSIAEEGLDIPEVDLVVFYEPVPSEIRYIQRRGRTGRKAAGSVVILAANDTIDTRHLYASKRRVERMKESLSSINAVLAPVKRAFLEPNPVTAEELAALEGWRARAEERLRKEVAEEIGKKKGGGPVDAAVLDAEVKSRIQQLRKKAISAEEEMLTGAFQREVERAARRIHTELAKAGVKGADVELLREHLSLDYPVLNEALKKLEKLRRLAWRNEDTVVLADNLAAAKGDIYSIRVEKVMQGRAVVMINKKWRARLNHYDYSGPRELLKKGATFDVVGELYRQEGVLGLKVKQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM5</accession>
    <name>K0IGM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC uptake transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10410"/>
    <dbReference type="EnsemblBacteria" id="AFU57983">
        <property type="protein sequence ID" value="AFU57983"/>
        <property type="gene ID" value="Ngar_c10410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10410"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.990"/>
    <dbReference type="HOGENOM" id="CLU_028871_10_0_2"/>
    <dbReference type="OMA" id="VQEPWGA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1039-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="362" mass="39503" checksum="D7210ED4588E4F84" modified="2012-11-28" version="1">MNNKLKLSIAAAIIVAVIATSVPLLAISGGSKNIASNNNPGTTLESTQQKTIRIGYFPNINHAQAVIGLGNGDFQKALGSNIKIKTQIFNAGPSAIEALFANQIDVSYIGPNPAINGYVQSEGKALRIISGAASGGAVFVVRNDAGINSVKDFANKKFASPQLGNTQDVALRKYLLDNGYNTKDKGGNVEVLPAKNADIVTLMIKKEIDGAWVPEPWGAKLVKEANGRIFLDERTLWPNGEFVTAHIIARTDYLEKNPDVIEKLIKAHIDETNWINSHPDEARKIFNEQLQILTGKTIPDDEFMDAMSRLKLIYDPVKTSLFESANAAYEIGFFEEKPDLSGIYDLNILNKILRERGLPQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH03</accession>
    <name>K0IH03_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gvpJ</name>
        <name evidence="5" type="ordered locus">Ngar_c22050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59135">
        <property type="protein sequence ID" value="AFU59135"/>
        <property type="gene ID" value="Ngar_c22050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22050"/>
    <dbReference type="HOGENOM" id="CLU_2353300_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="10720" checksum="2DB55AA9EC75A5FA" modified="2012-11-28" version="1">MLSSNRHELPARQLSLFDLLDRILDKGVVINGDITVAFAGVDLLSLKVNLVIASLETAKRYGIELPWEKWAREKAELEKKEKKIVGGGGKKELGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH64</accession>
    <name>K0IH64_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59225">
        <property type="protein sequence ID" value="AFU59225"/>
        <property type="gene ID" value="Ngar_c22980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22980"/>
    <dbReference type="HOGENOM" id="CLU_1302663_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2296-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="229" mass="25649" checksum="FC61AB4BBA2A72BC" modified="2012-11-28" version="1">MTLYLMTAEEKLVKRILSAGSAGIKKTDLRKELGDIDAALEKVISKGEVFVDKRAGAYYCFHKTHYIQSLLNSDPRFKLTYDMIQSLQASVSSSNKELAHTVETLANNISNLARFVLEIKNDQQSSLHQQMLATTNNVPIPTAPRRTMSVHDFKEEFDVALANSGSSIGWVELAKLRNELCDRCNITSDEFYRLVGELTSMHQDRYELSTGGGEGVMIRGLLHGFVRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB4</accession>
    <name>K0IHB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb4</name>
        <name evidence="7" type="ordered locus">Ngar_c13450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13450"/>
    <dbReference type="EnsemblBacteria" id="AFU58283">
        <property type="protein sequence ID" value="AFU58283"/>
        <property type="gene ID" value="Ngar_c13450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1301"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="CRVENLV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="322" mass="35735" checksum="8E46DF6A09AC6BBA" modified="2012-11-28" version="1">MQASVVCSACKNEVVVTDHECGEVICSRCGIVIDRVESPAVQDWRAFSVDEFYRKSRTGAPTSLARYNKGLLTSIGNSKANGLNFNRIRVWDFRIQAANDRSLKQALPELEHLKESLGLPDAIVEKSAYFYRKASRLGLIKGRTVSSVLAASVYLACRELENPRTLSEIATASNVARKKISRDYRMLVRMFDPKIPTVDHARCITRIANKVGVSEKTKRIAVKIMREIVAMQISAGKGPMGIAATVLYIACMHAGEVKTQKELSIAAGVTEVTIRNRYSELKKYLQDFAKSSTLAIAILMFVFQSPVIMHSATRYATTVLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHC8</accession>
    <name>K0IHC8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59335">
        <property type="protein sequence ID" value="AFU59335"/>
        <property type="gene ID" value="Ngar_c24100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24100"/>
    <dbReference type="HOGENOM" id="CLU_158398_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2408-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11540" checksum="5E1BABB6A29F66DB" modified="2012-11-28" version="1">MGQSYVTAKVENKYGDIVKINIEGGRLDIELQETLFKIKGKQLQLPRLAYIMTTINDTGKILVRKLHVIGVKDWLLIYEDDLFLLAVKDTYDELDIRVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHD9</accession>
    <name>K0IHD9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13810"/>
    <dbReference type="EnsemblBacteria" id="AFU58318">
        <property type="protein sequence ID" value="AFU58318"/>
        <property type="gene ID" value="Ngar_c13810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13810"/>
    <dbReference type="HOGENOM" id="CLU_1965441_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1379-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="12728" checksum="16ACDA5B38CA0461" modified="2012-11-28" version="1">MSSEDSASRIRSAASLLVKGGTLTSDACPKCGGVQVRFANKTTCINCGNEVKAGAAQKAEPEKAAPAQASSGLASAASLIEEKIMLLATEIKNESDISVQKQKAELLESYLRILEKTKSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU4</accession>
    <name>K0IHU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05080"/>
    <dbReference type="EnsemblBacteria" id="AFU57452">
        <property type="protein sequence ID" value="AFU57452"/>
        <property type="gene ID" value="Ngar_c05080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05080"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.486"/>
    <dbReference type="HOGENOM" id="CLU_040940_5_2_2"/>
    <dbReference type="OMA" id="YYIWGAT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-506-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="21286" checksum="45A7A79CD275014E" modified="2012-11-28" version="1">MLRKEEILSLLKPAIISDRPYLPADAASATPAAVLVIIHYHKEEDSPHVFLTKRSSNLKSHRGEISFPGGRYIESDGTLLATALRETEEEVGIAFTPEQVAGSLRAVHTMTSNHFIVPFVTVQDILPKYRTAASEVEAVIDVPLIETLRSIEPDTEHYGLAQDAFKFTYGNNVIWGATARILKQLHGLLIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU5</accession>
    <name>K0IHU5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25930"/>
    <dbReference type="EnsemblBacteria" id="AFU59515">
        <property type="protein sequence ID" value="AFU59515"/>
        <property type="gene ID" value="Ngar_c25930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2565"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_2"/>
    <dbReference type="OMA" id="IANTQRT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2593-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="329" mass="35687" checksum="5639E014FB9EF7EE" modified="2012-11-28" version="1">MLVCGAINWDTIVFVDELPKAGQEIHAREIISVPGGKGANTAVAAARILGAYQVQILGMLGLDDLAERHNAILKREGIDTSCLLRHKEAGSGQAYVIVDKKGENMILTYKAANQMIAPDVINNRMMQDAIKQVSTIVIIDPPLDVASALLEQGRQNDNKTLIWSPSLLTSHGLSALYEHMKLIDWITLNEQEARALTGSSTTAIDGMRACVMLSKKLGGGKRVVVTLGRKGCILCWNEKKALIPSLDLAQFGLKPVSSVGAGDTLLGALSAFKIKGFDDIESLFMANVAAALKTTKQETRGSPNYDEIKNMMDDKRVRTLFSQIVIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY6</accession>
    <name>K0IHY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57542">
        <property type="protein sequence ID" value="AFU57542"/>
        <property type="gene ID" value="Ngar_c05990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05990"/>
    <dbReference type="HOGENOM" id="CLU_677267_0_0_2"/>
    <dbReference type="OMA" id="MANDGYA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-597-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="406" mass="47253" checksum="398408F7C6296649" modified="2012-11-28" version="1">MDSVNQYAAINVKAKYENMKHMRILILGNMANDGYAVAKELRKMNVDVDLAVNISDFGMALPEWEDGTMSDKIDPYSIDGDAARKMWNPPCWIRYFDFLNKVPRKKHMMAKIQSRINLIRMMREYDIIECHVPFSIYSQFSGIPYVAYDAGWIRYFPYSNGFRDKLARRGYRKARKIIITNPDTFEISDGLPYLDKDKILFCPFAIDPEKYRPLDAKELRARYVNESDILLFSPTRQIWNEKGNDKMIRAYAKFVKEVPNSKFIMVAWSIDEDNSKRLASSLGISDKIEWIKPVPKNQLIQYYNASDIVLDQFILGSWGTSTPEAMCCQKPVLIFYKKNYIIRAFGEEPPILNSFTEEEICSNLLKLAKNLDFRAVMGKKSREWIIKTHSSRVVAERHLEILESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II27</accession>
    <name>K0II27_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57627">
        <property type="protein sequence ID" value="AFU57627"/>
        <property type="gene ID" value="Ngar_c06840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06840"/>
    <dbReference type="HOGENOM" id="CLU_2839482_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-682-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7308" checksum="D7A8EBB806E9332B" modified="2012-11-28" version="1">MIHAERGDIPTVTLRITGVYDDLCHSISFALQMQRIYERHPAAYFSPGDHSAGRQPYVHPVGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH0</accession>
    <name>K0IIH0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57857">
        <property type="protein sequence ID" value="AFU57857"/>
        <property type="gene ID" value="Ngar_c09150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09150"/>
    <dbReference type="HOGENOM" id="CLU_3194626_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-913-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="45" mass="5055" checksum="44361264EACD27D3" modified="2012-11-28" version="1">MKRTLPSENPPLVTNDSSYRIATSIEPHGCSIPFYYRTSAVLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK8</accession>
    <name>K0IIK8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57917">
        <property type="protein sequence ID" value="AFU57917"/>
        <property type="gene ID" value="Ngar_c09750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09750"/>
    <dbReference type="HOGENOM" id="CLU_126931_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-973-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="19692" checksum="1EFDFDD45B12DAE3" modified="2012-11-28" version="1">MSEEDERRLTQADSDINEKEEEEHLEKDGAVAEANEEGQESIQAGVTEEGEQQQEAAAAATTTTTMSPEHTLLLQVLRRAKRQQDLITQIQKSLKTLASIEKSIGKATEQVRLLQSAIRDSQRQITQIQHQVAALEKAQAKGFQKIAKQKRVAVGGGGMKRASSATTKRKKRGMSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL5</accession>
    <name>K0IIL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57927">
        <property type="protein sequence ID" value="AFU57927"/>
        <property type="gene ID" value="Ngar_c09850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09850"/>
    <dbReference type="HOGENOM" id="CLU_2875203_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-983-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7257" checksum="CD5B6C6E49807851" modified="2012-11-28" version="1">MADDELKRKMRDFVGNNTRLCVYQLQTIIDGNNIKGVVVAGVPDFPWICGDELYQNLSREFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN9</accession>
    <name>K0IIN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59790">
        <property type="protein sequence ID" value="AFU59790"/>
        <property type="gene ID" value="Ngar_c28710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28710"/>
    <dbReference type="HOGENOM" id="CLU_2802402_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2871-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7636" checksum="5B796634FE4EC8CB" modified="2012-11-28" version="1">MIVYVSHVIDRDSQIKIDPGKGIIHIVYDEPDIVSVAISIEREGYAVHSFTNPLEALEDIELRCRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ5</accession>
    <name>K0IIQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
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            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2340272_0_0_2"/>
    <dbReference type="OMA" id="MRTREDY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2019-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11165" checksum="2CF015DA8595FAEB" modified="2012-11-28" version="1">MAANLKDTCSEILSLDKSIRFAGIANIMGKVVAQEFRKDVTPLPSFEEVESSAIKSVLRMRTREDYEAKLGRAIYTFTLYEKSRGHQFRWNTGIMHY</sequence>
</entry>
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        <name evidence="3" type="primary">nuoI</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
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                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11560"/>
    <dbReference type="EnsemblBacteria" id="AFU58097">
        <property type="protein sequence ID" value="AFU58097"/>
        <property type="gene ID" value="Ngar_c11560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1096"/>
    <dbReference type="HOGENOM" id="CLU_067218_4_5_2"/>
    <dbReference type="OMA" id="GICANTC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="18341" checksum="72ED0E4B94A91F91" modified="2012-11-28" version="1">MTSAGGFIKAIESGSKHLVIKRFTFRYPEQKLKFVGDGYQFDPKRGVGIAGYRGRHILMHDKCTGCQLCAIACEGIAEAIGMVKVDESWKQNKKGIMPQIDYGKCVFCGLCVDACPFYALFMTNDYELSAFTKEHLIYTPAQLAIKPKYQGDVEIVIDDRGATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ01</accession>
    <name>K0IJ01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaerales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58117">
        <property type="protein sequence ID" value="AFU58117"/>
        <property type="gene ID" value="Ngar_c11770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11770"/>
    <dbReference type="HOGENOM" id="CLU_751461_0_0_2"/>
    <dbReference type="OMA" id="IVAPLWG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1175-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="112"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="368" mass="38551" checksum="ED71222F3CA47B36" modified="2012-11-28" version="1">MIAGFAIGRLVFDIPSGVLADRLGLNRTMILGLGVLVSSSVLAGFAPNYWVLLSARVFEGIGSSIYVGAAIAFVLLSSEASKRGTNIGSYQSMLMLGPIMGPIVGAPIAAFFGYNAPYLAFAAVIAVALAIVAALAYSGRLDVARPVLGHESGGSRKADMTVYLNTAAIATFGFAFLRSGIYTTGMPLFAYGSLSLSVFDVGIMLTMASIANLVSSFFSGKLTQMYGMQKPLFAAILSAAILVAIMPLSTSMLLLLAIVTLIGVTSGFFGQSIVWAAEQIEEKVKKKSVADAGRALGVHSHVTRGIGFNRMIGDLGLVLGPLFIGYFISAFTGNPLLWFVSFGLTGVVLGIVSFLILGTKVKCNIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ20</accession>
    <name>K0IJ20_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58142">
        <property type="protein sequence ID" value="AFU58142"/>
        <property type="gene ID" value="Ngar_c12020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12020"/>
    <dbReference type="HOGENOM" id="CLU_3057247_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1200-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5797" checksum="248055D14900E471" modified="2012-11-28" version="1">MMYGKLYVMPSSKDMKKNPETKGGAGPAANASFNPERGYGTSEQKEKIRQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ99</accession>
    <name>K0IJ99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58322">
        <property type="protein sequence ID" value="AFU58322"/>
        <property type="gene ID" value="Ngar_c13850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13850"/>
    <dbReference type="HOGENOM" id="CLU_2165350_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1383-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12570" checksum="D86092FDD6AE50C8" modified="2012-11-28" version="1">MPDWKDFTAILCALLIVVGAAAFAVAAQTFTIVRGKVLEKGIAELDLGDGRSYSVQTLSVLIENDDRVFRIERGTVVKYAISDSDAQLVDIGSDVELLISSYSNVARLIGHDGSNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB0</accession>
    <name>K0IJB0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">atpE</name>
        <name evidence="6" type="ordered locus">Ngar_c31890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31890"/>
    <dbReference type="EnsemblBacteria" id="AFU60105">
        <property type="protein sequence ID" value="AFU60105"/>
        <property type="gene ID" value="Ngar_c31890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31890"/>
    <dbReference type="HOGENOM" id="CLU_1335010_0_0_2"/>
    <dbReference type="OMA" id="YAGNIDC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="PTHR45715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="22624" checksum="7EAABC45A3F676EE" modified="2012-11-28" version="1">MSSNSALERTISKVLSQKEAELVSKIDSAYQESLNNLEASRGKLEAERTRIIGSAKKQAENLKRQIIGSARLAARNQELVTIENAVNNAFEEARKKLAASGGKDSYRALMSNIIEESVSSVGSGGVVIECNKNDAELVRKIVADLQQKNSKVQARVSEQHIDVLGGIRVKSADGTMTFDNTLDSRIERLKPLIRKNIAQMLRGGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN9</accession>
    <name>K0IJN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58497">
        <property type="protein sequence ID" value="AFU58497"/>
        <property type="gene ID" value="Ngar_c15640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15640"/>
    <dbReference type="HOGENOM" id="CLU_1127115_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1562-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="246" mass="27796" checksum="2629F014CAA47E69" modified="2012-11-28" version="1">MTEKEEDAKSGTVTMKISSAIRDELKKIAEASGKSLHQVTEEVFFAKLAIQKEQDGAINKADAECSVFELAIKYKVDVIKQLTAAANLKLKMEQIALTHDKREKLKNGDIPKIEYRNKYCCPQCGEAFAEPLNCMSHFNEKHERQEQESKALYLCPYCPTERLCTSAGALQAHFLTEHKDRFNPPPSPIQRPIPNSPTVQEKIIYQDREVKVYACMCGKLCKDITELGTHYIKCEKIKIIAGRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX6</accession>
    <name>K0IJX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA methylase N-4/N-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c35020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="55345">
        <property type="entry name" value="M.Nga92ORF35000P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60415">
        <property type="protein sequence ID" value="AFU60415"/>
        <property type="gene ID" value="Ngar_c35020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35020"/>
    <dbReference type="HOGENOM" id="CLU_1792192_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3503-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0680">Restriction system</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16305" checksum="DBEFCD743BA9B97A" modified="2012-11-28" version="1">MMEEDARGRIVVPKGGGVPRHKHYLDEQEGVPVDDIWDDIDYVKGSERLGYPTQKLLELVERIINTSTYKGDWVLDPFCGCGTATTAAEKLGRHWIGIDITWLAINLVKNRIKAMFPDAKFDLEGEPKDIGAAKELAKNRYQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK17</accession>
    <name>K0IK17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58632">
        <property type="protein sequence ID" value="AFU58632"/>
        <property type="gene ID" value="Ngar_c16990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16990"/>
    <dbReference type="HOGENOM" id="CLU_2712967_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1697-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="7741" checksum="FC44537095FDF8BC" modified="2012-11-28" version="1">MSQKTVFAIQPFEMGGGGTPHRSLVIVIPAAVVKALTLSKSSILELRLDSELKKITLQPLNTPEVIEENASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF8</accession>
    <name>K0IKF8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59733">
        <property type="protein sequence ID" value="AFU59733"/>
        <property type="gene ID" value="Ngar_c28130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28130"/>
    <dbReference type="HOGENOM" id="CLU_2821041_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2813-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7820" checksum="ACB8F211AD964D89" modified="2012-11-28" version="1">MGGISKTKLMYNTYVSYSKLKQHVNLLILSGLLEYDSIDHVYRTTEKGINFLNTYKQIRRLHIHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKJ5</accession>
    <name>K0IKJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58982">
        <property type="protein sequence ID" value="AFU58982"/>
        <property type="gene ID" value="Ngar_c20500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20500"/>
    <dbReference type="HOGENOM" id="CLU_2271126_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2048-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11683" checksum="0B390B566A6A37B3" modified="2012-11-28" version="1">MHPVSLIAGVLSVVWCFDTIDYDEQVSSYCTQTFVILDKWLNQLGREKGDEALKIIKEALRNNTKANITYYQEFAKEAKENGHVELASQNMLLARLYKGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR0</accession>
    <name>K0IKR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21820"/>
    <dbReference type="EnsemblBacteria" id="AFU59112">
        <property type="protein sequence ID" value="AFU59112"/>
        <property type="gene ID" value="Ngar_c21820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21820"/>
    <dbReference type="HOGENOM" id="CLU_3039180_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2180-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="5941" checksum="8FB1E7C9E311918C" modified="2012-11-28" version="1">MQASIDQLKGLPPALVITDENDVLRDEGEDYSHKLMQAGVTVTATRYLGTIHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL32</accession>
    <name>K0IL32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59292">
        <property type="protein sequence ID" value="AFU59292"/>
        <property type="gene ID" value="Ngar_c23670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2339"/>
    <dbReference type="HOGENOM" id="CLU_176725_0_0_2"/>
    <dbReference type="OMA" id="DMDGIGH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2365-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="11207" checksum="13CC4E495C26A9A7" modified="2012-11-28" version="1">MKKGQFYFIYDMSPHLVLEDKTKRGLEVREHVIDEKYGVEADRGMIHDMDGIGHKVGIRWYFPQSKYTLDQVVKIAEEIEARYKAIRDITCPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL67</accession>
    <name>K0IL67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32630"/>
    <dbReference type="EnsemblBacteria" id="AFU60178">
        <property type="protein sequence ID" value="AFU60178"/>
        <property type="gene ID" value="Ngar_c32630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32630"/>
    <dbReference type="HOGENOM" id="CLU_012358_1_0_2"/>
    <dbReference type="OMA" id="TDNFMAN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3263-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="53"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="399" mass="43239" checksum="684660C1675B6326" modified="2012-11-28" version="1">MSLVITNASLLLGKELDYVEKGYVEIKDGRIKSAAAGSYRGPGRKKLDASGFLVIPGFINAHTHIADSIGKDIAAGHRLNARVHPVFGAKKKILQKSQPEHLKAFIRNSAISMMKKGIIAFADFREDGPGGVKLLRDAIADLPVKCVALGRANYYSNPKDVAGLPPEAIGQTQQVLEIADGLGISGANENTDMALSQYRQLAGEKLVAIHAAESKETVEFSKAHTGRSEVARVMDHLKPDFIVHMANATEDEISVTAKNRTGIVVCPRANGVLGAGMPRVALMLRHGCLVAIGTDNVMLNSPDILRELDYIWKASRATEGEEMIEPRQLLKMATVNAAQILRLNSGCIEAGRAADLIFVDKKHVDLYPMHDPYAAVVHRLSQNSIRAVMIDGRFVEAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA9</accession>
    <name>K0ILA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60288">
        <property type="protein sequence ID" value="AFU60288"/>
        <property type="gene ID" value="Ngar_c33730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33730"/>
    <dbReference type="HOGENOM" id="CLU_2821046_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3373-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7463" checksum="618C93673C616944" modified="2012-11-28" version="1">MLIALKAILYLMKSEPGMSRKEADDLLSLMGDDEEMRSRLAEVLKSELAGSSRRARAVRDVGRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB7</accession>
    <name>K0ILB7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56989">
        <property type="protein sequence ID" value="AFU56989"/>
        <property type="gene ID" value="Ngar_c00390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00390"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-39-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="12070" checksum="CD64F758B52FCC77" modified="2012-11-28" version="1">MRQWHLEHMQKTILKYVKGLSADANSWERRNHKKYGNITNVCRQIEYDMRHGVTKEELLASFSKIHTHSSYRALRRDSDSMSRLLEIEEHFTTPKAVTPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILF6</accession>
    <name>K0ILF6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rpl44e</name>
        <name evidence="4" type="ordered locus">Ngar_c00990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00990"/>
    <dbReference type="EnsemblBacteria" id="AFU57049">
        <property type="protein sequence ID" value="AFU57049"/>
        <property type="gene ID" value="Ngar_c00990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00990"/>
    <dbReference type="HOGENOM" id="CLU_114645_3_0_2"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10602" checksum="57A7D550330602DC" modified="2012-11-28" version="1">MKMQKEMRKFCPKCKTHTVQSVALYKKGKDRIVAEGARRHAEDKKGYGGQKFPELKRTAKTTKKMTLRYTCKTCQYKTMKEGLRIRKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH6</accession>
    <name>K0ILH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c01340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57084">
        <property type="protein sequence ID" value="AFU57084"/>
        <property type="gene ID" value="Ngar_c01340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01340"/>
    <dbReference type="HOGENOM" id="CLU_061942_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-134-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="89"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="366" mass="40744" checksum="B9A572E53E0C3406" modified="2012-11-28" version="1">MCGAQNYFVAGDPATTAAAKKKNSSGSAGKIVAACVLVTVVAVALFIFAPAILGVITQQQDSNPAFSILQPQGQEPVTVPREELVQHALDLINKDRADFGLPPVQLSSNQAAQVHAEDVFRTKRISHWMTNGEKPYMTYTRYGGEGSVQQNVAIAGFSPEQYEQCRTNILLDCERIEPLSTIAELQYEMMYKDKECCDNGHRYNILDPRHTHVSIGIVYDRYYLAFVENFENNYGLDISVNNGQVTISGQLLEGQELQQIDIYYDEIPTREIYEQNKHMLSYSAGELVAAVVEPLPLGFYYEKPEGLILIEANRWGQGDDSPSSVDVMFNLASAVRKDGVYTLFAVVEDGEERFKATSYSIFVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP7</accession>
    <name>K0ILP7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57204">
        <property type="protein sequence ID" value="AFU57204"/>
        <property type="gene ID" value="Ngar_c02560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02560"/>
    <dbReference type="HOGENOM" id="CLU_2103622_0_0_2"/>
    <dbReference type="OMA" id="ADNIPEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-256-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12706" checksum="519B2AA57AC2A48C" modified="2012-11-28" version="1">MVVVAMQYFMALKMGEKRVRAAQELLTRYAGHAMPALALKDNKDNKWEPVGEETLYAVVKEDAGYMIAFCDRNGIAKSIAQWFSEDVKNEIVAKIKAEQNMQEYFGKLSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX9</accession>
    <name>K0ILX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59782">
        <property type="protein sequence ID" value="AFU59782"/>
        <property type="gene ID" value="Ngar_c28630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28630"/>
    <dbReference type="HOGENOM" id="CLU_186514_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2863-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6335" checksum="A6F609E3220269E8" modified="2012-11-28" version="1">MGNKPSKCALCGSDLGAFTYRPMPQWNISGIICGQCYDKKLTEHYIAPDRRDVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ5</accession>
    <name>K0ILZ5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59827">
        <property type="protein sequence ID" value="AFU59827"/>
        <property type="gene ID" value="Ngar_c29080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29080"/>
    <dbReference type="HOGENOM" id="CLU_1136083_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2908-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="28660" checksum="0B83194E1F9952C6" modified="2012-11-28" version="1">MFDKNWKPTLTYPERYEEIGVVDHVLEYLRASNKRDIVIVDIGCSTAVATKQLKNMLDNSGIKNRTIGIDLSQTVREEAMQNVDLFLNQDVMYVDSTLYPADIVICCNMIFYLNHLKKAEVISKCSQFMKDDSVLITNTPLFEQPSDYAQLKLFLRDYVPVMLTIFYNPKRFYGRYKETESIRVKRRMFSFHGKNEAVAYAGRIITSWENLPLGQKFGWYIEMARAQFLTKVRRLKPRSKKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM06</accession>
    <name>K0IM06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59857">
        <property type="protein sequence ID" value="AFU59857"/>
        <property type="gene ID" value="Ngar_c29390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29390"/>
    <dbReference type="HOGENOM" id="CLU_175270_2_0_2"/>
    <dbReference type="OMA" id="TEVIVRW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2939-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8862" checksum="CE55C45E04D54FD8" modified="2012-11-28" version="1">MSNTSNLSIRIPKEVKEQMKDIDDVVDWPDYIRAAIESKIKETKRKKAARSMDAIRSKTRYGEFDSVKSIREDRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM77</accession>
    <name>K0IM77_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60072">
        <property type="protein sequence ID" value="AFU60072"/>
        <property type="gene ID" value="Ngar_c31560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31560"/>
    <dbReference type="HOGENOM" id="CLU_2911657_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3156-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6838" checksum="BEF13A37638F50DB" modified="2012-11-28" version="1">MARDILNEKAHEQSYLISELESLGLTSVQVNEFNDNKELHGLVKSIKDAFLAEYRKGSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM93</accession>
    <name>K0IM93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60112">
        <property type="protein sequence ID" value="AFU60112"/>
        <property type="gene ID" value="Ngar_c31960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31960"/>
    <dbReference type="HOGENOM" id="CLU_2519882_0_0_2"/>
    <dbReference type="OMA" id="ILTRMIW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3196-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9142" checksum="7E2755D3F3B689E1" modified="2012-11-28" version="1">MSRTALKFESQRIDKLPPDILIKGTWVSTAMALILTLPSLGLFIGLYEMGINIGISAGIGFGLHFALLAFSRRISKAISSLFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM98</accession>
    <name>K0IM98_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60132">
        <property type="protein sequence ID" value="AFU60132"/>
        <property type="gene ID" value="Ngar_c32160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32160"/>
    <dbReference type="HOGENOM" id="CLU_117038_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3216-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="195" mass="20609" checksum="8FAEA85AB6C0664A" modified="2012-11-28" version="1">MVNNNTMTMTMAADARSSGYVTKSSAWSNRFIIAAIVQGAVITGLTLAVVAAQMLTSGVNIIQFLSLSFEGPAKWFFLGYIFYLILVVAIAVTAVFYSHLEVSMGRQIRGFRSVLAWIHFAGMNVGGAVTTIAMIFAGLAGSGILGIILGGSDSLQPNTAIMEQFVPIIAAFTGLLSIGVLAGGLAYILTYLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD8</accession>
    <name>K0IMD8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="6">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ribD</name>
        <name evidence="11" type="ordered locus">Ngar_c32620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32620"/>
    <dbReference type="EnsemblBacteria" id="AFU60177">
        <property type="protein sequence ID" value="AFU60177"/>
        <property type="gene ID" value="Ngar_c32620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3258"/>
    <dbReference type="HOGENOM" id="CLU_036590_4_1_2"/>
    <dbReference type="OMA" id="CECGQEV"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006401">
        <property type="entry name" value="Rib_reduct_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01508">
        <property type="entry name" value="rib_reduct_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="10">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="224" mass="24441" checksum="C5992D304B8D0FA9" modified="2012-11-28" version="1">MRVIMNGAMTVDGKIATASGDSKISSKEDLVRVHKLRATVDAVVVGISTILADDPQLTVRLVKGKNPTRIIVDSRGRIPIDSQIMRTASKIKTIVAVTDQAPEEKIHKLEDMGAKVLVISEGKKGQSAAVPHGVNLKELFRRLEKMGLRRILVEGGGELNWSLLRLGLVDELTVTIAPRIAGGRLATTLVEGDGFDEIAQGIRLKLVKVERKKTGELLLRYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG6</accession>
    <name>K0IMG6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60262">
        <property type="protein sequence ID" value="AFU60262"/>
        <property type="gene ID" value="Ngar_c33470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33470"/>
    <dbReference type="HOGENOM" id="CLU_175266_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3347-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="12576" checksum="E18AC47A2724E787" modified="2012-11-28" version="1">MDDNSKRFLANQLLWIGIYFGIAIVVGIFLDFPISLIVIIAIIIPLSLYRRRQIMKRMGGQQGTGSFFGGIRGGGGGGMFGSKGGLSYYCISCGTKHNQAECPKCGSRMKRAAFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH4</accession>
    <name>K0IMH4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57899">
        <property type="protein sequence ID" value="AFU57899"/>
        <property type="gene ID" value="Ngar_c09570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.914"/>
    <dbReference type="HOGENOM" id="CLU_448082_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-955-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="609" mass="68829" checksum="52E33F6ED4B17DF9" modified="2012-11-28" version="1">MPERVPDVTKLKILRLWLAGESRDNIARKTGVGTGTVSNVISEWRTSYANYNIDALRELGIAMKNAGITPKEAADAARVFNMLTKNNVKLDDLDFFISDAYKTCSNTGLPTERLVDLLNQFFALSSSLNIPAEELPIQLAKLKNEVEGLKKSKIELEQELSNKETTLLDLQQFVTAREMLREHLGDDNGNFSIVEHLPKLANMLRNAKEMQYNPSKIISKISKIKSLQEQESALRVAIENKERRYRYFARESQRLENKVNSLSQTVRFYKELKAMGFGLRQLRLLHSILEELVNDSIIIDSIFAVETPGKAAVTKFFRDLEEMYPQLLDYQERIRQLKVDAENYNYLAENAKKRYADRKDLIDTVEILTNRKGFNRDDIIYLQSIIMKHNIGRANKKKFAADLDKYGSIEDAIADSSFQLGELQKQEISLQARIKQLKSDVEDLEAKRIAISESLKDGALFIQALLAQAEAEAKQGISSVVQEARQGMQTAKELLDECKKISYETIATVSKLNLEVSKQFESISRLEGFKDLAEVISIASAIDTNEKLGASSRELLPKLDLHTIGVLSMLISAYEKYGPEAKVITEPFSRVRALLATFVATSHIGAKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN3</accession>
    <name>K0IMN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60432">
        <property type="protein sequence ID" value="AFU60432"/>
        <property type="gene ID" value="Ngar_c35190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35190"/>
    <dbReference type="HOGENOM" id="CLU_2949429_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3520-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="7162" checksum="F3A5A98C68A115F3" modified="2012-11-28" version="1">MSLDDNDELAYLWTKVKFVQRYMSKNNCTFEVAEREFHTWIEGLMDSRIERANKMLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW9</accession>
    <name>K0IMW9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58354">
        <property type="protein sequence ID" value="AFU58354"/>
        <property type="gene ID" value="Ngar_c14180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14180"/>
    <dbReference type="HOGENOM" id="CLU_023853_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1416-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="323" mass="37146" checksum="E2EC17B06687D5F5" modified="2012-11-28" version="1">MYNLGVFQTIAIDDIVYSTNILRNPRQSLDQLAVSIMQRGLIHPVVVRPKNNEYRYELIAGYRRFEACKRLGMQKIICHIVDVDDKEAYEISITENVQQQTMSPIEEAIAFKRYIETFGWGGVSDLARKIGKSQEYVSKRIKLLSLPESLQKDIAQGKINVSTAEELFPLSNTEIAENLGDYILENNLSAKEARRVVKVFKENFKDLDVSLDKSNNELEFLLPRQLTEEYIDDNNSSSANQSELLFRVANPLLKRCALGIRLSLRNIDDIIGDIEDDRASSTLDSFWITKELLMQHRIRLHEQLDQLLRQASKLKNLQKLQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN29</accession>
    <name>K0IN29_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ordered locus">Ngar_c17210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17210"/>
    <dbReference type="EnsemblBacteria" id="AFU58654">
        <property type="protein sequence ID" value="AFU58654"/>
        <property type="gene ID" value="Ngar_c17210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1695"/>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_2"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="18334" checksum="7AEE792D8441086B" modified="2012-11-28" version="1">MKKALVGIIMGSDSDLPVMKEAKEVLDSFGIPNEITIVSAHRTTRRMVDYASGAKKRGMEVIIAGAGGAAHLPGMVASLTPLPVIGVPVRTKSLDGLDSLLSIAQMPPGVPVATVAVNGAKNAGILACQILAIKHQDIARKVEKYKRDLESSVLKKAGILEKSGVKRYLKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN32</accession>
    <name>K0IN32_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl29p</name>
        <name evidence="4" type="synonym">rpl29</name>
        <name evidence="5" type="ordered locus">Ngar_c17360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17360"/>
    <dbReference type="EnsemblBacteria" id="AFU58669">
        <property type="protein sequence ID" value="AFU58669"/>
        <property type="gene ID" value="Ngar_c17360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17360"/>
    <dbReference type="HOGENOM" id="CLU_158491_2_2_2"/>
    <dbReference type="OMA" id="MTRISMK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7952" checksum="3063F0D135692F42" modified="2012-11-28" version="1">MARLKLKTLREMNDQDLADKLAELKADLAKLKLEQSKGTLKKQTGNIKWLRRDIARMMTLLNERKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC4</accession>
    <name>K0INC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c21990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21990"/>
    <dbReference type="EnsemblBacteria" id="AFU59129">
        <property type="protein sequence ID" value="AFU59129"/>
        <property type="gene ID" value="Ngar_c21990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21990"/>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2197-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="30546" checksum="ABA679DCD9F19890" modified="2012-11-28" version="1">MVRLQRSNTDKIEDADIIVIGVPDESKSHAKRKGTSRAPDVLRIASNESEFFERGGKRIPTFPMRGTFEHKRIFDAGNVASKQELRKMVSDIVSRGKLPVMIGGDHSLTTETLHAASGALGKKLSLLYFDAHPDFVSSTRNYYGSVLTDSAQSLNLRKSVLIGTRAAEPEEIENAKVAGLKIVNPLDVVELGVKRIAQMIKTRTAGSKTYISVDLDCVDPASAPGVSVPSPAGLAAIDLIYLLNSIISGGNVIGIDIVELTPDYDVNGMTAALAARILSECIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF0</accession>
    <name>K0INF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23330"/>
    <dbReference type="EnsemblBacteria" id="AFU59259">
        <property type="protein sequence ID" value="AFU59259"/>
        <property type="gene ID" value="Ngar_c23330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23330"/>
    <dbReference type="HOGENOM" id="CLU_1465195_0_0_2"/>
    <dbReference type="OMA" id="FNEERFW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2331-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="20739" checksum="0205D2A5BA02737B" modified="2012-11-28" version="1">MVHLQNRSSYTPKDAAALLYSAKELVEPEVTIRDVRVSKKYIEFDTSLPDHMNVDYLIGRLVAISPLATYEHIVERHMSKDEAIERAVNLFNDEKYWGAHEALESVWKSADGTEKSILNGIILVAAAFVHDEKNEPDICLSILQRARKKLEGTGGMYHGIDIDRIADRVSEIINSGRIERFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK9</accession>
    <name>K0INK9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">Ngar_c26320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26320"/>
    <dbReference type="EnsemblBacteria" id="AFU59554">
        <property type="protein sequence ID" value="AFU59554"/>
        <property type="gene ID" value="Ngar_c26320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2606"/>
    <dbReference type="HOGENOM" id="CLU_079546_0_0_2"/>
    <dbReference type="OMA" id="MGGTHPG"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="116"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="228" mass="24007" checksum="92E3EBEF6B191688" modified="2012-11-28" version="1">MGAKERIVIKLSGRVFGDDAAGELKKYAAMLLEVSRQMQPVIVAGGGKIARHYISVARAFGSDEASLDIMGIEVSRLNARLLIAALGDHAYPVVPADLEQVSEAAAGGKIVVTGGLHPGQSTNATAALIAEKVRATKFLNATDVDGIYDSDPNKNKDAKLFKEITVKKCLELLGSENSAAGAYDLMDIVALKVIERSKIPTVVLKSDPATIKSAIANNKPIGGTRIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL7</accession>
    <name>K0INL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59594">
        <property type="protein sequence ID" value="AFU59594"/>
        <property type="gene ID" value="Ngar_c26730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26730"/>
    <dbReference type="HOGENOM" id="CLU_2243949_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2673-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11901" checksum="99177EA1584FB00E" modified="2012-11-28" version="1">MNCVTKFNAGSNSGFGYRHSLCGFGCSLFRPPTPVEHSASVDISDFGLTTYFLFSDVESKVLNFTVDWDTSLILMNVDVPQNTELRIRFHEHLFEQLEHQQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX4</accession>
    <name>K0INX4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Sm-like ribonucleoprotein, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32130"/>
    <dbReference type="EnsemblBacteria" id="AFU60129">
        <property type="protein sequence ID" value="AFU60129"/>
        <property type="gene ID" value="Ngar_c32130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32130"/>
    <dbReference type="HOGENOM" id="CLU_145829_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3213-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028277">
        <property type="entry name" value="Lsm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037156">
        <property type="entry name" value="Lsm_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14894">
        <property type="entry name" value="Lsm_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Lsm_C" evidence="2">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15365" checksum="092F81B35E32E10F" modified="2012-11-28" version="1">MAAVVTRKFGEETLQFLGKKVSVETSDQKVYNGTLAGIDEKLDVVLDNVEGRGILKVIINGAFVKEVRLMEKPFDFKALAERLSRVFPGLVKIREDVGAIIVMDKIKVTQSGVEEGSGLAADRVRSIYDEFMRETTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY1</accession>
    <name>K0INY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome, subunit alpha</fullName>
            <ecNumber evidence="1">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psmA2</name>
        <name evidence="1" type="ordered locus">Ngar_c32480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.25.1" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32480"/>
    <dbReference type="EnsemblBacteria" id="AFU60164">
        <property type="protein sequence ID" value="AFU60164"/>
        <property type="gene ID" value="Ngar_c32480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32480"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24055" checksum="73B226CCC45D61DD" modified="2012-11-28" version="1">MTAETGSYGSATRYPYFYGPEGRLVLVDSALEAVRRGSTTIGIKTPAFALLASHIKPVRPLIDPAEKIFTIDGHVGATGSGYIGDILQLIEELRLEAQKHRLNFESPIDIGSLAKHLGSFLHNYTIYAVRPQAASVIVAGVDQAGVQLYQVDPSGTFMRGSGFVIGQSADIALDVVQREYSADMSVEQAVGLSNKAIEKALGERPVVEIGVVTAQDRRFQKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY9</accession>
    <name>K0INY9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c32890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32890"/>
    <dbReference type="EnsemblBacteria" id="AFU60204">
        <property type="protein sequence ID" value="AFU60204"/>
        <property type="gene ID" value="Ngar_c32890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32890"/>
    <dbReference type="HOGENOM" id="CLU_063749_4_0_2"/>
    <dbReference type="OMA" id="IHCGDFV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3289-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="18315" checksum="BB03B427D5BD782A" modified="2012-11-28" version="1">MKIGLISDTHDNIRNIEIATEIFAERKVDLIIHAGDITTPEAVEAFSDSIRVIGVLGNNDVDIKGLTNAFQKIKGELRGDFCEIEQDGLLIAVYHGTEFKRRESIIQSGKYDVVVYGHTHKTENNIVGNKTMVINPGTANGWFFGYRATAAILDTITKECEFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I761</accession>
    <name>K0I761_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cysteine synthase</fullName>
            <ecNumber evidence="2">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysM1</name>
        <name evidence="2" type="ordered locus">Ngar_c01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.47" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01510"/>
    <dbReference type="EnsemblBacteria" id="AFU57101">
        <property type="protein sequence ID" value="AFU57101"/>
        <property type="gene ID" value="Ngar_c01510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.151"/>
    <dbReference type="HOGENOM" id="CLU_435909_0_0_2"/>
    <dbReference type="OMA" id="MDICPAP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="443"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="511" mass="56233" checksum="E9EAACA97FD7AE89" modified="2012-11-28" version="1">MLEDFEREIWSKVPHLEDKSGKVVNATPLKDITADLKECAKSVFGIDLADKNLRVFGKFDSKLLAGSIKSRPAVNILRDAIATGKIKRGQTIFEATSGNFGIALGLIGKRIGLNVVTLVSRKLQEGVFEELRNEDIRIVNLDMDICPAPGMKGDANLMAAKATAWNVRAQLSELGFDPAIFDRSRSEIEAVLAKQDIINLAKLLAKVYDGCFCPEQYDNELNIEVHRTVTGPEIEQQLHEQGHSLADFRIVCTFGTGGTSGGLSRYMMEKHGKKAVHVIFPPADQDVAGIRTKAKASGLKFYEPDQYAGQHEVDFGGQAKRLLKFFVDKGYDMGESSALALYAAMQMANFGGEGRFVVIIADGIQKYRKNLEAMQQQQKQKRLEVPLQEAVSNIGNYDRVVWIHTMYTPRKEGIELIAKTLGIDESKIYVPKASEVEQLLMTQQIPKEMEKSLGGPDSKPLLVCMMGNTSLRVAQVLGQKGIGAESLTGGINTLSQGKGKHISELVRMATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7P6</accession>
    <name>K0I7P6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03280</name>
        <name evidence="2" type="ordered locus">Ngar_c03570</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57276">
        <property type="protein sequence ID" value="AFU57276"/>
        <property type="gene ID" value="Ngar_c03280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57305">
        <property type="protein sequence ID" value="AFU57305"/>
        <property type="gene ID" value="Ngar_c03570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03280"/>
    <dbReference type="KEGG" id="nga:Ngar_c03570"/>
    <dbReference type="HOGENOM" id="CLU_2930303_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-328-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6707" checksum="F7A969A7D447DA3F" modified="2012-11-28" version="1">MTTLIGFCHICGKKLKGENKQGLMISRGKHYINVHGLNISIVENGHIQVIYIVPARTLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I870</accession>
    <name>K0I870_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57466">
        <property type="protein sequence ID" value="AFU57466"/>
        <property type="gene ID" value="Ngar_c05230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05230"/>
    <dbReference type="HOGENOM" id="CLU_3178700_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-521-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5500" checksum="86E1A9C2F4C6C52D" modified="2012-11-28" version="1">MCDWYLFLILGRLSRNEFLKCAGQMIHAEKEKNISQQQLCWLDGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Z3</accession>
    <name>K0I8Z3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase, IS605 OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c07890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57731">
        <property type="protein sequence ID" value="AFU57731"/>
        <property type="gene ID" value="Ngar_c07890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07890"/>
    <dbReference type="HOGENOM" id="CLU_032903_9_3_2"/>
    <dbReference type="OMA" id="SCNKKHG"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="17571" checksum="E21836C8022F4DC3" modified="2012-11-28" version="1">MYERIHNKRRDFLHKLSNYYSSRYDLIFLERLRVANLTKNHRLARKILDASWSTFKQMLQYKANRVVEVEPAYSSVDCSRCGHPVPKSLAVRTHVCTECGAVLDRDYNSAINILKRGLESLVLLLLLLLLPVERREVTRLWRSYYNSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9U5</accession>
    <name>K0I9U5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit L</fullName>
            <ecNumber evidence="8">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoL</name>
        <name evidence="8" type="ordered locus">Ngar_c11600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11600"/>
    <dbReference type="EnsemblBacteria" id="AFU58101">
        <property type="protein sequence ID" value="AFU58101"/>
        <property type="gene ID" value="Ngar_c11600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1100"/>
    <dbReference type="HOGENOM" id="CLU_007100_6_2_2"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="183"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="692" mass="75428" checksum="FFEC87B74344D8E4" modified="2012-11-28" version="1">MAVVGFEGIAINAWLVWILPFVGAAIIAAVARAGHRIRDYTAVAFALASAISAATLIPLALEGSEVHSQIPWISSLGLKAGILADPLAIVMTNLVAWISFLIMVYSTGYMHGDKDLTRYWFFMLFFIGSMQLIVLSDNLLMVFFGWEGVGLASYALIGFWYHDRKKDFVGREGHVAGGIPMWASPTHAGMKAFLMTRAGDTMMLAGMFLIFMHAGTFGFKELVEDPSWAFAMSQQNLLVPAAVLLFGGAIGKSAQFPLNEWLLEAMTGPTAVSALIHAATMVKAGVFLVARIGPLFFALATIGAFSVERFFEVVAWVGAITAFLLATQALVNPEIKKVLAYSTGSQIGYMMMGLGIAGLSLNFVDGYTAGFFHLMSHAMFKASLFMGAGAILHTVGSRFMTDMGGLKKHMRKTYIFMLLASLSLAGAPLFTSGFWSKDAIFAAVLDSGYAYSWPLFTIAVVVAIMTAFYTFRMIGMAFFGRGSKHVEEMEHHGHLHEVGRSMWVPFAILAVASIAIGVVGFAFEAQIHHLFAVYLEESFGIHGEEEHTEEVTIPIAPEGDRTFLGLHPLAAAASVGAFAIGGALGYVFYIGRKADPQVISRSIVTRAIWKFLYNRWYLNTALYWGGVVGPLAIYRIVWRYFESTIIDGMNPALQHSMAYMSRVVKGGQTGITQTYLFVFAVGILIIVMLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAA4</accession>
    <name>K0IAA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13130"/>
    <dbReference type="EnsemblBacteria" id="AFU58251">
        <property type="protein sequence ID" value="AFU58251"/>
        <property type="gene ID" value="Ngar_c13130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13130"/>
    <dbReference type="HOGENOM" id="CLU_626433_0_0_2"/>
    <dbReference type="OMA" id="VFGWGKK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1311-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="427" mass="47939" checksum="087E6E37B8B27DCE" modified="2012-11-28" version="1">MPFGLFKKKESETSAKLPAVSMPAAGMLSIQQAQDLLHNIESARVQELAARLAPIKESAEESLRVIEGIANDMEHEKIKFEGVEHRFKSVAENARKTIVSSLRREASTELLLPQSANDAKKFKEKFETMMNRFGEVSGSHSRVITTFMKKQASKMREEFEALTKLLNETKTIMSDFEQKRAPIVKCNAILNTASQKASSIRAAEASLQSIKNEIERIENELQGLKGELAALKGSPEFEQAVAVAQMVDEVERQKEQVHSQLADLFSHVSRAFTKYSYGLTKETEARLQMMSDEPWRMLYESDISTYSSLLAEIRKSIESSKIQLKDSDKVLHYLNAISGSLPELQGKAQALKTEADLLRQKDGGLTGRAKELEGRILQHEEELARSRQSLEQQKRQITEKSAEVGALLNEADEILADLTGQKYSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAT1</accession>
    <name>K0IAT1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58441">
        <property type="protein sequence ID" value="AFU58441"/>
        <property type="gene ID" value="Ngar_c15060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15060"/>
    <dbReference type="HOGENOM" id="CLU_154322_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1504-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="18002" checksum="936FF2E92653A620" modified="2012-11-28" version="1">MEKEPASWTDLIHESVYASDDADIGDIEAINRYFLVVKSGLLNVRRYYIPVTRVEGWDGKVVWLKVPEAHVKSRYRKDDAPDPYYYHYSGAPPADEDAVRDLLIDLPKIPAKYEEDRPFLVAAASPKTPEPLHVFRCDLCNITFRTEDELSSHILGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBL9</accession>
    <name>K0IBL9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Ngar_c00100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00100"/>
    <dbReference type="EnsemblBacteria" id="AFU56960">
        <property type="protein sequence ID" value="AFU56960"/>
        <property type="gene ID" value="Ngar_c00100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00100"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.11"/>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_2"/>
    <dbReference type="OMA" id="CVPPQNK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-10-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="48"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU56960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24835" checksum="1B2CF4E6265120E4" modified="2012-11-28" version="1">MNTEKLRKLNAQITKCELCPRLAQYIRQVGQDKVRRFANEQYWARPLPSWGDPNARLLIVGLAPAAHGGNRTGRMFTGDSSGDWLARAMHETGFASMPTSRSRDDGLVLKDAYITAAVRCAPPDNKPLPSELRNCSQYLISELKLLDKVRVVLALGKIGFDAYCRAVGAKGLSFGHGARHQVDGKTLLASYHPSRQNTNTGKLTWPMWLRIFKTASAIIEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBZ3</accession>
    <name>K0IBZ3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OrfB_IS605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57070">
        <property type="protein sequence ID" value="AFU57070"/>
        <property type="gene ID" value="Ngar_c01200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01200"/>
    <dbReference type="HOGENOM" id="CLU_1821073_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-120-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="1">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="16845" checksum="266B1A9AC692920E" modified="2012-11-28" version="1">MVRQILLWLSKLGFIKIRLHRQPTNIKQVTICRQNARWYAVIACDTKPIFRFVHSNRSVRIDVGITKFVYDSDNHFADNPLFRTRMSKPLCRAQRKLCRRQKGSKNYEKTKNWVAMLHEVIARKCKTFCIRYRVIMLTGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC41</accession>
    <name>K0IC41_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01610"/>
    <dbReference type="EnsemblBacteria" id="AFU57110">
        <property type="protein sequence ID" value="AFU57110"/>
        <property type="gene ID" value="Ngar_c01610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.160"/>
    <dbReference type="HOGENOM" id="CLU_745145_0_0_2"/>
    <dbReference type="OMA" id="GTAGRNM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-161-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="380" mass="42888" checksum="3ED5E17485FF988E" modified="2012-11-28" version="1">MSGKDESIFSMEALRSTQAGKDIMKQGLLRSKGYRQFNQYKEKTEQEFSGFAQRFIMSLHKAITADPNPAGTIRKFADDMGSEELALSDGSSVADVKARLSNPDVLGDRIKRILNSNFVKMTFPVFNALYDGASEYFGDSASEENRNAVIDGHIIAIDLSEPMDRIVDRDEDLEYLDDYKFMNPYILGIACSKIAQGGDSVLKAFEEGFKDARIGQYIDVKLKIKPASINDENMTECYKKYRAVMGTAGRNMALNRRPLSDIFHLGMAKAGECVGCGNEIEDAIKNNAVKVPSWPLYYALNTGGDVRRAFELTMAKSELYLDEAKIALDMLPENFKLKPFLEFLFLTVRHYNQYWYNELIRRAPFAEFQKKIEESVAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC83</accession>
    <name>K0IC83_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl15p</name>
        <name evidence="4" type="synonym">rpl15</name>
        <name evidence="6" type="ordered locus">Ngar_c02010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02010"/>
    <dbReference type="EnsemblBacteria" id="AFU57150">
        <property type="protein sequence ID" value="AFU57150"/>
        <property type="gene ID" value="Ngar_c02010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02010"/>
    <dbReference type="HOGENOM" id="CLU_109163_0_0_2"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="5">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16126" checksum="3095B3835A899A36" modified="2012-11-28" version="1">MATRFRKSRRQRGSRYCGWGQIGQHRQAGSRGGIGGAGKHKHFWIRTVIEEPDHFGHDPFNSFNRNLVQRWINVRDLDAVFAKHGKADESGKVVLDLTSLGYDKLLGGGSISGAYAIKVAKVSESAKSKIEAAGGEVIINEQYDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC92</accession>
    <name>K0IC92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57160">
        <property type="protein sequence ID" value="AFU57160"/>
        <property type="gene ID" value="Ngar_c02120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02120"/>
    <dbReference type="HOGENOM" id="CLU_942045_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-212-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="295" mass="33164" checksum="3447861912D1D590" modified="2012-11-28" version="1">MPSFVAAALVFANFSLGYFRLPESMRKEEEAAGTKTSSRETLATMFRTIAAKTDMKLLLATYFIAMLAFFVLDGTGTPWSKEVFGFGPFQVGLLFFFIGLVSAIVQGLVIPKLSEIFPATAAGNRHHLDRDRSWNARSHYKLQPAGPASKLHSDFAGNEIWHGFNQHACIAKSRHRQAGKCAWGNAVSLRDCADHRSRLWSLRLWLWSLCRNRRAALHRCCGNCNTGHRDEHALSQKRSWPKGDVNAAVWCECHGDKRLLTVASSNTEERYRGILYVLLPLFLFNASKKKCQNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICM7</accession>
    <name>K0ICM7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purN</name>
        <name evidence="5" type="ordered locus">Ngar_c04380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04380"/>
    <dbReference type="EnsemblBacteria" id="AFU57385">
        <property type="protein sequence ID" value="AFU57385"/>
        <property type="gene ID" value="Ngar_c04380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.420"/>
    <dbReference type="HOGENOM" id="CLU_038395_1_0_2"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="22264" checksum="89A66660DB429ACF" modified="2012-11-28" version="1">MTINLGILISGRGSNMDAILGAIKSGRIKNTKPSVVISNKPDAAGLKIASEKYGVPAKVVPADGLKGWDYDQKVVAVLQAHGVTPQSGLVCLAGFMRIISPEFVRQYKMRILNIHPALLPSFPGLHAQKQALDYGVKVTGCTVHFVDEGVDSGPVILQKAVPVMEGDDEEALSARILEQEHQLYPEAVRLFCEGRIKVQGRRVLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID54</accession>
    <name>K0ID54_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl18e2</name>
        <name evidence="4" type="synonym">rpl18e</name>
        <name evidence="6" type="ordered locus">Ngar_c23910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23910"/>
    <dbReference type="EnsemblBacteria" id="AFU59316">
        <property type="protein sequence ID" value="AFU59316"/>
        <property type="gene ID" value="Ngar_c23910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23910"/>
    <dbReference type="HOGENOM" id="CLU_146465_0_0_2"/>
    <dbReference type="OMA" id="WRLERPR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_L18e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="PTHR10934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="5">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="12799" checksum="CFBC1FDBDE7F7B3D" modified="2012-11-28" version="1">MMFANTMVDNTIWTLRSAFKKNKAPIWRALEEELAGPRANRREINVRRLAEITKAGEVVVIPGKILGTGSLGHKLTICAFSISETAAKKVVESGGKVVTFEDLIKKHPDGKGVRIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDG8</accession>
    <name>K0IDG8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57685">
        <property type="protein sequence ID" value="AFU57685"/>
        <property type="gene ID" value="Ngar_c07420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07420"/>
    <dbReference type="HOGENOM" id="CLU_1574997_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-740-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="18438" checksum="839A1F0F3DF60D4F" modified="2012-11-28" version="1">MSQAENVNVIVTVGDVKVQFSGSAESVMASVMSFLSKQVPSMDLAKKISLNYSAQELVEAYSHLIKITPEGPRVISDSDTRLSDKDVVALQLVAAKIAKDLGRLQDDAMQVAEMHATTALNPKSISSRISEMVKAGHVARDEKEPTKYRITTAGIHWLNSTIAKKVRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDM3</accession>
    <name>K0IDM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59496">
        <property type="protein sequence ID" value="AFU59496"/>
        <property type="gene ID" value="Ngar_c25750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25750"/>
    <dbReference type="HOGENOM" id="CLU_3178703_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2574-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5090" checksum="C163059A263FF113" modified="2012-11-28" version="1">MLAVKSEAVDLSLGRSAIDFIDSLMPQPSQVVKLRPERLVAQKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDP2</accession>
    <name>K0IDP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell wall-anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08830"/>
    <dbReference type="EnsemblBacteria" id="AFU57825">
        <property type="protein sequence ID" value="AFU57825"/>
        <property type="gene ID" value="Ngar_c08830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08830"/>
    <dbReference type="HOGENOM" id="CLU_228780_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-881-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2430"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2248"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2248"/>
            <end position="2263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="2466" mass="264711" checksum="1AF31420A1CD85F8" modified="2012-11-28" version="1">MKEEKYRLSDQADGKAKIVLAGAIDNRHIVTIMLLLAVGIAIHFVSTELLQPVFAERYLTPLPEASSTQQVPAGNSYYRSMSESMAVVASYGSGSANSPMSYQRSMSESMSVTTVQGKPTNSYSRSMSEQVSLSTGMPSAPMQPARINAEGSGGSSYSLSNLRSDERSRILGKGNNALGRIAGSGTSIYSSGSNQGITEDETASFDIISRIFRRTSSGDDGSDGESSQESDSNSNNFVLDYTGLDGKFLEKRLAAGNVGSNTSNFIGYYYVNVINGFYSIGVIAIVAKRSRIILRSRHKLAKTAELVGFTVESKASRACLVVLVLFIVIAVAGSFGALPIDAVFADDALASAYVSATGTFGTKSAKYREWNPITSTWSSEVELPDTGSPISSVKILFSPINSMRVIISYSNNGALNLFTCSSACTTASSWTRVGGASFATAALPSSNPSKPYDIAFEQSSGRLVIVYDKDLNEENDFYYRTFNGATISAESGLSYIGLPLLGDSEFIRTFKMASKPGADEIVMILEDVTNQDAYAFVWNSGSSSFGNQFTVSSAMGTTSVAGFAIDVAYETSSGAAVVFAGNGANSAAYVRWDGAWPLLFASTTDPNPLSNNDVRFVTLKADPVSTSNKIMICQVDDLSDLTCAQIDGGVLGAWTKHDDNVDNTSRRVFDFAWNPTGSAGVLVWGTTSGSIHYRQWSGTVWSTAFYAVPYANTKAWVVGTTNPMSRKSAFLVLNGASDIGSLIYDGLELKVIGTQTHTADTASVLNEALSIDYQRRPAVRAILESVFVSDSVGNRADNPAAIVYRSNTGANGLHSVKYREWNPTTSTWSTEVELPTTGNDVRDAKILFSPTSTLRAVVSHSADGSLNLFTCSSACTTAGSWTRVGGASFADTGSPIGDVPYRPYDIAFEQSSGKLVIVYDKDLTENNDFYYRMFSGGILSSETGFSYIGGAADSEEIRYFKLASKAGSNELTMILEDATNTDTYAFIWNSVSGTFGNQKTVSTALSTANTEGESIGAAYETSSGASVVFSGNGANSAAYARWNGASWSAVSTTDPNTNSGNDVRFVTLKADPVSTSNKIMICQVDDLSDLTCAQIDGGVLGAWTSLNANLDSSTSRPADYVWDSSGSTGLAVYGTTTDVITKRAWDGANWSGATSVDSVGTHLWIVLVRNPLGSDKNKALMGMINSNADIGTMVYDGTNVKNLGDSIHTAFLTNMDFEAVSIDFQRYGRVISRPININLAVTDAISVAFTRQVSEQLHLTGTINRTLGSPYTRSMSDQMMTVTDILARSVTLSRSISEVLAVNDGITKNISKSMTDQLRLTDSIQRTVVAARAFSEGLGVTEKITKALSKTITQQLTLTEAIARSTTASKSITEQLAIQDTIAKAFAPSRSLSENLAVTETTTRTIVTSRALSEQITLTETVAKSISVSLSEQLTTTDQLARATITSRAVTEQLTTAEFIANLVSKAISEQLSITENIARSIVTARSVSEELGLTESVAKRITHSLSEDLSVTDTIDRSSTLSRSISEQLALTETALINTSKPLTEQLAVIDSLERSITTTRTLSEQLGVTDAVSKAFSTALLEQLGITESPARVAALSRSMSEQFTLVDSISKDVSVLQTEQLAFADTLTRITALTRAMMEQLAVNETMTISISKSMSEQLRMTDELQRSISVTAAPSEQQLALTDSIAISLSKSLSEQLEVEDTIARSIALSRSISEELTVNDQISKAISKVISEDLAVTDEIQRTIVSTRNMSEQLGVTDTVTKAISVVLLDQLGVTESEIGSIEVARSMSEQLTITDFLIEGRAFQIAISEQLSSTEATTATTTTSLPSSLIEGLATSDAITTTTSTFARAITENMAITENASRTASIIILEILQTSDQFTDISIHYHLVLGETLVLPDSFATDHASYVNSFIGHKVIIEDSVLLALKSTNNPTEQLVVQDQLSAMHTNRRVLTETMQLRDSRIIVATRPPPSPPSAIVAMPVVTMTEKETVKEYPNSMTSPMVAVQVQGTYPMERLDNTALGSLLTTIGMPVYDVSTEASSTGIDNMTMILPTFKVPIEMDGAPLNGGAFLTPVLSNVPANTQVVIPIDVEGSLGAGTIETNRMILSFTPKVNSSNFALLISILDNNPEEAITQEEPEGLSAFYIDVSYVGTWPGGISPSDPAFYFEPPQVTFTITEEWTEENHAKRDLNNIPMINLFLLNEVTGTWIEISDDKITPLTSAVGNVYQYIVTLPHLSTYVVTADTSSSESGNRGPGSGIGTRGSSRFGHIVQLAESLSVSGSINLVKGESLFSDLTGSFNINKVDSKPLDQRVISVDDISVTVHVSGIRSSAILGTAVARLNFEIENKGDIGQELMLRYWYSDPTTKMRIYENKETVMVGAGQSIVKIFEVPFTSPGDYSLVIEVESKEGTVSTTDIAINVPWLTVYLYILVIIAVIVIGVSMGFVIFAIRSRRFIITGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDW2</accession>
    <name>K0IDW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC uptake transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26490"/>
    <dbReference type="EnsemblBacteria" id="AFU59571">
        <property type="protein sequence ID" value="AFU59571"/>
        <property type="gene ID" value="Ngar_c26490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2624"/>
    <dbReference type="HOGENOM" id="CLU_028871_10_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2649-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="352" mass="38139" checksum="64A9CC0B00DC7057" modified="2012-11-28" version="1">MHSGVKLGVAGAIIAAVVFTSTPYFGFSGNDGCNFSNFGQSDVLRIGYFPNINHAQAVIGLGRGDFQEALDGIEVRTQIFNAGPAVIEALNAGAIDVAYVGPNPAVNGYVESNGCNLRIIAGAASGGAVFAVRGDAGIDSEADFAGKKFASPQLGNTQDVALRKYLLDHGYETKENGGNVEVLPAKNADIVTLMVKKEIDGAWVPEPWGAKLIKEANAKILVDERDLWPEGEFVTAHVIVRTDYLQNNPDTIRKLLEAHVDETNWINENPDEAIQVFNTELEKLTGKTIPEDEFEEGLSRMTLTWDPIKESLFQSANDAFDIGFLRARPDSGIYDLDLLNQVLSERGLPEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE86</accession>
    <name>K0IE86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57118">
        <property type="protein sequence ID" value="AFU57118"/>
        <property type="gene ID" value="Ngar_c01690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01690"/>
    <dbReference type="HOGENOM" id="CLU_1648357_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-169-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="18539" checksum="A69712465BE9AFBF" modified="2012-11-28" version="1">MISSDNEKTATKVVSKSLHEDRLRPVIINQKRREALKRAIKRNTTCIHSTVYSQVTFVCRRITLSYEEGKISEKQAMDLIFEAHDQMAHQGLPKEIVTEEMHKRLDKLEGGDKSLFGIVMANTNSSIYLRKKPSALKEKEEIYDSEEEEKYSESYWADVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE99</accession>
    <name>K0IE99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57133">
        <property type="protein sequence ID" value="AFU57133"/>
        <property type="gene ID" value="Ngar_c01840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01840"/>
    <dbReference type="HOGENOM" id="CLU_1615358_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-184-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="16680" checksum="7E602F7DBA84AC64" modified="2012-11-28" version="1">MSDDQDSRSGRNYSPSVGEAVEEATKSGRVATREGATSGTGGGEPLPAGKTPEPQAQTRGPTAHDMDAVGSGTRTLDASTPHVIADSRSATSAGGAIGAGSATYARDVTVPADIDTEAAKSLRRDKETTDFRGARGAPGVGVPTGAAANTDKISREKRKVIDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEN3</accession>
    <name>K0IEN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC uptake transporter, putative heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02900"/>
    <dbReference type="EnsemblBacteria" id="AFU57238">
        <property type="protein sequence ID" value="AFU57238"/>
        <property type="gene ID" value="Ngar_c02900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02900"/>
    <dbReference type="HOGENOM" id="CLU_038034_9_1_2"/>
    <dbReference type="OMA" id="QCDVCAV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-290-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="305" mass="33905" checksum="34A8FFEA5CA13958" modified="2012-11-28" version="1">MRIVSFLPSATETLYQLGAGGQIVGVTHECKFPAQARKKPKVIRPSFDPEHMTGRQIDSKIVELMRSGKDIYIVDDKVLKKASPDLIVAQGLCEVCSPFTKEISRAVSVLGGRPDVLVLDPHDLDDILVSIMDVAEKVGRVREGRRLVASLQKRIDVVRNMKIITKSRPRVLCIEWLDPLFTAGHWVPQMVEYAGGINGISVAGEPSRRMEIDEAVQFNPDIIVLMPCGFEIPRTLKELPALARNEKWKSLRAVKSNNVYAVNANAYFSKPGPRTVVGLEILAKILHPEASRHIRVPKGSYLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEN5</accession>
    <name>K0IEN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59816">
        <property type="protein sequence ID" value="AFU59816"/>
        <property type="gene ID" value="Ngar_c28970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2874"/>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="OMA" id="WGPGRSD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2897-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="19807" checksum="1FB8B189FA0CE5B7" modified="2012-11-28" version="1">MPIDPEFPRKHEVIGKHQHADGEHFHFVWGPGRSDAETSTNEEVQAAYKARGEEYMPLGVHGTMVAVDWDSCIADGACIEACPVQVFQWYRTEQDVPAIQMQNATSAGTGSTVKEERKDYTDKSDPIREHDCIWCMACVSVCPPQAIKVDQSNLEFHEKASGTFNEALAKGSAPPPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP2</accession>
    <name>K0IEP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <ecNumber evidence="3">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hemL1</name>
        <name evidence="3" type="ordered locus">Ngar_c12850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12850"/>
    <dbReference type="EnsemblBacteria" id="AFU58225">
        <property type="protein sequence ID" value="AFU58225"/>
        <property type="gene ID" value="Ngar_c12850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12850"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1232"/>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_2"/>
    <dbReference type="OMA" id="NFGMVEP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="442" mass="48260" checksum="3BE9EB4929A41E31" modified="2012-11-28" version="1">MRDYVEDYMRKTTKSKCLYSRSARVFPGGISHNIRYFEPYPFFVNSAKGKQLHDVDGNRYTDYWMGHWALILGHSPKPVADALAAQVRNGTLYGTVNEVSVELAETIQKLMPRAEMMRFSSTGSEATMYAVRLARAKTGRRVIAKAIGGWHGFNTTLMQTVNYPFEVEEGPGLVQDEGQYVESIPFNNLDASLKVLETIKDDLACIIIEPVLGGAGCIPPVDGYLQGLQEFAKKNGSLFILDEIVTGFRLSLHGAASVYKLEPDLFTLGKICGGGMPIGVVCGDKEIMSLADPVSRKDKEARCAIGGGTFSANPVTMTAGLATLNFLKKNKSVYSKIDRLGDVARKGLSKIFAEAGIPSKVTGLNSIFMTHFGKEMVQDANDVATSNKELLTRYHLALMAGHGIFFLPGKMGAFSNAHDESDVKRLLAATEKIVQSGLFKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IET7</accession>
    <name>K0IET7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59871">
        <property type="protein sequence ID" value="AFU59871"/>
        <property type="gene ID" value="Ngar_c29530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29530"/>
    <dbReference type="HOGENOM" id="CLU_046519_3_1_2"/>
    <dbReference type="OMA" id="CYFDNDV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2953-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="31713" checksum="A512C6605F304F60" modified="2012-11-28" version="1">MTILSGTCGWSYQEWVGAFYPNNRVAKLPFYSRIFNSVEVDSSFYRAPSKSMVAGWIKATGPDFKFSLKIPKSVTHDKRLAGAEKEFLDFVELVEPMARVGKLGCLLVQLPPDFTFKERGSLESFLSLLPRDIHFTVEFRHESWNRKETWELLEKYNVANTVTDSPIEFLSRPVVTATTHSYVRWHGRGKSIWYDYTYSEEELRPWLTKLQVMEERVPVVYAYFNNHYHASAPTNLLQLLEMRGEDMTDAQKKVKARAERHEHRKAVKITDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEY5</accession>
    <name>K0IEY5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c13980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13980"/>
    <dbReference type="EnsemblBacteria" id="AFU58335">
        <property type="protein sequence ID" value="AFU58335"/>
        <property type="gene ID" value="Ngar_c13980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13980"/>
    <dbReference type="HOGENOM" id="CLU_558539_0_0_2"/>
    <dbReference type="OMA" id="LKLGWPA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1396-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="447" mass="49788" checksum="E8F18703CDA118E6" modified="2012-11-28" version="1">MGSAVALPPAISAIQFPFELKKDQLEAAEAWIGNGCRGSVIFSTGTGKTEIAFECARRAAELSGQDRFPILFLVPRIVLVEQNVRRLQAYSIPDDYIGVYYGERKDVREITISTYQSAINNHHLIRSARMVVLDEVHLVSESAVAFDSIFDVIVEDPAKAILGLTATINEKDPKYQTILTVAPPVKKYMIKDAVTDGRLAKPVVQPIQVNFTPEEQKIYDEASAAIKDISRKLQAYDPVKMTKILMRGGSRGSMAKMWFAHVRKRKELLSATEQKLLKAADLVRRHPNERIMIFSETIDSIQQLKDLLEDSGIPAQTIHNGIKPRERQEILESWGKDYFPLLSVHTLEIGYDVPQVGIAIIIASTSNMNQVAQRIGRVVRKTEGKDQALVYVVYVSGTKDDNVLKVVKAAIEKDGNERKAAVRAPAARDSSNKRPAHGQRTLTKFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF51</accession>
    <name>K0IF51_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative SnoaL-like polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04940"/>
    <dbReference type="EnsemblBacteria" id="AFU57438">
        <property type="protein sequence ID" value="AFU57438"/>
        <property type="gene ID" value="Ngar_c04940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04940"/>
    <dbReference type="HOGENOM" id="CLU_100997_5_2_2"/>
    <dbReference type="OMA" id="DIQWSVE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-492-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="167" mass="18881" checksum="15F07C52EB121A14" modified="2012-11-28" version="1">MKHGMSSLEEIEKQNIRIARRVFEAFNTGDVSKVSEFIGPEYFNHESQADPRRGKLRGPDEVIDTIKNLRGAFADLYYEEKETVASRDKAVSIMQVSGKHVGNFFGIAPTGRSFSYQAVHIHRIANGKVVEHRSIRDDLRFMMQLGLVGPGSPQYAPLFEVWKGAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF74</accession>
    <name>K0IF74_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57468">
        <property type="protein sequence ID" value="AFU57468"/>
        <property type="gene ID" value="Ngar_c05250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05250"/>
    <dbReference type="HOGENOM" id="CLU_3130969_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-523-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5466" checksum="844935388829A425" modified="2012-11-28" version="1">MCNYWCKAHGYGCDSEGDWQTHLLTYPHKGANVIMPGREGKPEEVTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF84</accession>
    <name>K0IF84_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60026">
        <property type="protein sequence ID" value="AFU60026"/>
        <property type="gene ID" value="Ngar_c31100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31100"/>
    <dbReference type="HOGENOM" id="CLU_3039185_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3110-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6084" checksum="56C835B8EDBB09D5" modified="2012-11-28" version="1">MSIPVPGYCANCGGLIKMLVRLTRRGVPSRLPLFCSEECAREYLLRGEANSLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA5</accession>
    <name>K0IFA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/cation antiporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c15510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15510"/>
    <dbReference type="EnsemblBacteria" id="AFU58485">
        <property type="protein sequence ID" value="AFU58485"/>
        <property type="gene ID" value="Ngar_c15510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15510"/>
    <dbReference type="HOGENOM" id="CLU_077877_0_0_2"/>
    <dbReference type="OMA" id="GGLLICY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1549-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="185"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="342" mass="36151" checksum="DE0731EC9FF413B8" modified="2012-11-28" version="1">MLLWLAELTGASFLLSYGAEHLSKKYGAKFVGRTLLSVATTLPEIAIVIYAAADGLYGTAIGAGLGSNLLMMTLGLSIMLLIATTRLSKAPLKGVDVTTFKLDKIFLLATAVISAVLFIDGYNFIDGFIFAGMFGAYLIMALMEMKAESKAKKEVVEAGNPGHKVVKVDGGLPGKGPNREMTKAMLAFVAGTAGIFFGASPFIESLEGFSLEVGVSVIILAVIISPIAGEMPEKISMMLLARKGAAGASIAVANVLGSKILNNTLLLAVAVFGAMYHGGFYANIALNPILEYQMILVTVVTIGALIMMFKKEIGLKVGIILAVMYIVSLFIQFLLPQDLTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFG0</accession>
    <name>K0IFG0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="9" type="ordered locus">Ngar_c16170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16170"/>
    <dbReference type="EnsemblBacteria" id="AFU58550">
        <property type="protein sequence ID" value="AFU58550"/>
        <property type="gene ID" value="Ngar_c16170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16170"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1585"/>
    <dbReference type="HOGENOM" id="CLU_052778_0_0_2"/>
    <dbReference type="OMA" id="KYMPYSC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="PTHR10537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="348" mass="41145" checksum="A572E87A8C2B1996" modified="2012-11-28" version="1">MSIRIGPKDWADDPLQNEDLAKYPFLNDVSEYIRQTHFDFEEYNRPEFKDIIETAIERIETEASGRLYEKLDRFQREVFIFLATLIIVKSIGIESVLRKYSLFEAMRAEKFLTEDLKRERNEQKRRLLLFKIFKELFNVDIDIDADDERLFKVKITDYLKRASHFHEQEWKLINRMVNKGYVYLDADETVRLFRNELGALVYDKVKMMQLLTLPEALKTKIEELRTKMTHRYEYRATAVTDYPPCVKHALEVMGRGENLPHSARVMLATYMLAIGKPVDEIVMMYENAPDFNEKITRYQVEHLAGMKGSRTKYSVPSCDKLRNENLCFATAECDGIINPIQFGRKMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFN9</accession>
    <name>K0IFN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c16970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16970"/>
    <dbReference type="EnsemblBacteria" id="AFU58630">
        <property type="protein sequence ID" value="AFU58630"/>
        <property type="gene ID" value="Ngar_c16970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16970"/>
    <dbReference type="HOGENOM" id="CLU_057056_0_0_2"/>
    <dbReference type="OMA" id="VISEKTH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1695-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="105"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="403" mass="47401" checksum="ABA09CEE43927439" modified="2012-11-28" version="1">MEKCYRNFIDTCKSPVTKANYDLHLSQFKDWMKAKKYSDLLKYKPKPLQEKIIDYINYMKKQKQSPASIYAKLSGIRHFYVMNDLVLNWPRIKKFVGASTKVKVTQDRIYTKEEIRKILEKCDERKRVLVFLMLAGLRIGALPGLKIKHLTKWKEFKPEGAEKPIPLNVYQIIVYAGEPEEYTTFTTVEGAQAIDSYLDYRRRYGEEIKPDAPLIREQFKPENAKEPRPLSLHAVKFLLERALLDAGVRQRGKDYTKRQEVMRFHGFRKYFNTMLQKAGCKPAIKEMLMGHKMGLEDSYLRPDDEELLTEFLKALDLLTISEEKLLKHEVEKLKAATADLDTMKKGYIDIKLELEKKEKEMEKRLEEQDKKHKEDLDKRVAEAVEKYIQTVSGRVDFSKLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFQ2</accession>
    <name>K0IFQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58645">
        <property type="protein sequence ID" value="AFU58645"/>
        <property type="gene ID" value="Ngar_c17120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17120"/>
    <dbReference type="HOGENOM" id="CLU_1582944_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1710-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="18711" checksum="4A0E568EF6ACA9DF" modified="2012-11-28" version="1">MTEVSGSLTVTFNVKNAGDLQRILDICKEFDGSFNGSFAQPMPHEPQIRQQQPNPSPSISKEETYDRIIKLLKSTFPRDGFAMRDAATLVAEKLHYQRTTVRNAITWARNKGELLKQGHGYYFRDFIQQQVAAKIQEQQQSPPPAANSSNDNAAADGNFPVLPIGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFW0</accession>
    <name>K0IFW0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57698">
        <property type="protein sequence ID" value="AFU57698"/>
        <property type="gene ID" value="Ngar_c07550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07550"/>
    <dbReference type="HOGENOM" id="CLU_1965639_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-753-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="16085" checksum="039F133F058B9EAF" modified="2012-11-28" version="1">MFGSRNSGKDNDERGGRPASTFIDEPWFADLQKLNNDELMRMYTMISDRHYRFAKNAWYIPIGGDQRCPIMVAKGYRSPDTLDRMAEFEDTAKTLEGEFRHFIDAWDFGYITERDIEKAILKILESRNIEITEHSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFW4</accession>
    <name>K0IFW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57703">
        <property type="protein sequence ID" value="AFU57703"/>
        <property type="gene ID" value="Ngar_c07610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07610"/>
    <dbReference type="HOGENOM" id="CLU_1451454_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-759-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="21119" checksum="945D131E56724B15" modified="2012-11-28" version="1">MSSEYRFTDGNLIVLYAVHKGRSADGGLPDYIQERVKLGLETYSMVMRSRPDKHKTMVMIVGEQEPAEKVKEALVQGGVKPDIIAIDTDSQNMAQTIDRIAGMIKSKPNPPFVYFVGSVWLHDIFDSTVVSKLKGYRIQFYGALDHRPVDEVEKEKALDVPKKGIEYYKQKAKNKAVDVLLNIIFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG03</accession>
    <name>K0IG03_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58715">
        <property type="protein sequence ID" value="AFU58715"/>
        <property type="gene ID" value="Ngar_c17820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17820"/>
    <dbReference type="HOGENOM" id="CLU_165240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1780-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="12452" checksum="2DB56FD848774D96" modified="2012-11-28" version="1">MNKPIIMMALAAVAVFATPVIVLQTAYAQGLYGGGGGTASPEQLKECEQLGIDRNECNDTTLLAKRRLIAAQENPSTGSGTPMLSTETGQMAVFIGVLGAIFGGVAAAFFFKGRGAKPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG94</accession>
    <name>K0IG94_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c18830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58815">
        <property type="protein sequence ID" value="AFU58815"/>
        <property type="gene ID" value="Ngar_c18830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18830"/>
    <dbReference type="HOGENOM" id="CLU_113181_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1881-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="23418" checksum="6DA81884B1D6E8F5" modified="2012-11-28" version="1">MDERTQREQQEATIRSIDETRDNIRRAIEETRREVPRFSQTITDLQNETADATREIADTFLESQKDVLNSMQSAWRDMADRAGYWMEWMQPWNWWTGGIQPRNMADMYARMVSSTAENFAAGTRMTTNMMFAGAEAARAATRYARENAKEVSKMTSNTARAMGHMTKEAIRVQTEGGGGPTTAGAAGAGAETAAGGEEGPTRGETGSTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGG9</accession>
    <name>K0IGG9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mercuric reductase</fullName>
            <ecNumber evidence="6">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">merA1</name>
        <name evidence="17" type="ordered locus">Ngar_c19680</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + Hg + NADP(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58900">
        <property type="protein sequence ID" value="AFU58900"/>
        <property type="gene ID" value="Ngar_c19680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1947"/>
    <dbReference type="HOGENOM" id="CLU_016755_1_1_2"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045340">
        <property type="term" value="F:mercury ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050787">
        <property type="term" value="P:detoxification of mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021179">
        <property type="entry name" value="Mercury_reductase_MerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02053">
        <property type="entry name" value="MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="14"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="15">
        <location>
            <begin position="352"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFU58900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="477" mass="51933" checksum="925C60F193655B22" modified="2012-11-28" version="1">MKKSKREKTMENKYDLIIIGGGAAAFSAAIKANAYGVKTAMIERGRLGGTCVNVGCVPSKNLLAAGEHLQSARKPAHPAIKPCDADFDFTRIIHDKDKLVGNLRKQKYNDVLESLQYVQLIEGSAAFVSKNQVKVDGKVLSGKKFIIATGSSAFVPKFKGIEDIDYLTNIEALSLKEKPSSMIVVGGRALGLEFAQMYSRFGTKVTLLQRSDRIIPEHEPEVSAALHRYLAEECIEIVTGVNVKEAWQKNGGKFIRASVDDKDRVFEADQLLMATGRKPNTADLHLENVGVKVRQDGAIVVNSEMRTSAPHIWAGGDVVGEPMLETLAAKEGATAAENALTGSHKKIDLLSVPSAIFTSPQVASVGMTEKQMMQRYGYCSCRTLDMDKVPKALTVNDTKGLIKMVVDPKKKNRIVGVHILSSIAADMIHEAVLAVKYKLTVDDIIDTVHVFPTMNEAIKLVATSFKQDVSKLSCCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGL7</accession>
    <name>K0IGL7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58960">
        <property type="protein sequence ID" value="AFU58960"/>
        <property type="gene ID" value="Ngar_c20280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20280"/>
    <dbReference type="HOGENOM" id="CLU_1902007_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2026-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="15330" checksum="15E53A75AACD73B4" modified="2012-11-28" version="1">MSPSSGISSEQIASIDISPFWKKNEPLLRELERSEMPSKSRLIYKEIASNTDSNNNHILTNYDLVNIYDNRKHFFGIVAELSPDRSSVIREEIVAGNGLSNAKKTMVDGSRISNKAHIDWLKTMSQNDVCRLFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN3</accession>
    <name>K0IGN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10510"/>
    <dbReference type="EnsemblBacteria" id="AFU57993">
        <property type="protein sequence ID" value="AFU57993"/>
        <property type="gene ID" value="Ngar_c10510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10510"/>
    <dbReference type="HOGENOM" id="CLU_1478852_0_0_2"/>
    <dbReference type="OMA" id="NGVWHAR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1049-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="20346" checksum="220F0BD0C7CABC94" modified="2012-11-28" version="1">MGNLRRSRGYSYEHTLVQRLNNGVWHARRLGGSSTGLPDIVAVNNTSGILLIIEAKSGTSDILYVPQDQIERCLIVRNMFSIYPKRHIILAFKFMSKKRFRRKNKTVYESRKLLEYYKVADIVADMKVLPIIKCTYDGRMYAIHKDKTVALGLPDYSMPFQKSVQQVAKVAAATAEGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH14</accession>
    <name>K0IH14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A2M superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57102">
        <property type="protein sequence ID" value="AFU57102"/>
        <property type="gene ID" value="Ngar_c01530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01530"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.152"/>
    <dbReference type="HOGENOM" id="CLU_088139_0_0_2"/>
    <dbReference type="OMA" id="NQINVEP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-153-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027560">
        <property type="entry name" value="PEFG-CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04296">
        <property type="entry name" value="PEFG-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="275" mass="29417" checksum="AEFAB5481ED2BFD1" modified="2012-11-28" version="1">MDYKAYALVAILMASVASVGVVGAAYAQTLTIETDKDSYASGDEITISGQLTAPTINQPILIRVFDPDGNFVRSEILDAAADGSYSYTFTSGGPLMAKSGTYRVQATYAGTVNQETTFEFQATEETWRTFNIRVGGQTFPVQYRITGGSVQNMVPDEATATLTVTISSTSDGNLQIRLPRNVIDSRDGADGRSGSDLDFAVFIDDENVTPEQTEATVDRRTLSIDFANGTETIEIVGTWAVPEFGAIAAIVLAVAIVGIIVATARYGKFNFAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHC6</accession>
    <name>K0IHC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59330">
        <property type="protein sequence ID" value="AFU59330"/>
        <property type="gene ID" value="Ngar_c24050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24050"/>
    <dbReference type="HOGENOM" id="CLU_188388_0_0_2"/>
    <dbReference type="OMA" id="TEECKFC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2403-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018592">
        <property type="entry name" value="DUF2024"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023122">
        <property type="entry name" value="NE1680-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09630">
        <property type="entry name" value="DUF2024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160766">
        <property type="entry name" value="SSF160766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9916" checksum="FC7FD7B4C76FECCB" modified="2012-11-28" version="1">MECAVYDTYVTKKDGRIMHFDVVVEASTPHEKAIEYGKQYLVTAGQAGQKMTSEECQFCHIQEAPPFVEKAIRQNGYWIQKMEGCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE4</accession>
    <name>K0IHE4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
            <shortName evidence="1">LP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">cofC</name>
        <name evidence="2" type="ordered locus">Ngar_c13860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63424"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:59435"/>
            <dbReference type="ChEBI" id="CHEBI:59906"/>
            <dbReference type="EC" id="2.7.7.68"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.68" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13860"/>
    <dbReference type="EnsemblBacteria" id="AFU58323">
        <property type="protein sequence ID" value="AFU58323"/>
        <property type="gene ID" value="Ngar_c13860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13860"/>
    <dbReference type="HOGENOM" id="CLU_076569_1_1_2"/>
    <dbReference type="OMA" id="HYDEDSY"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="216" mass="23841" checksum="AB2E71BE60A3E93B" modified="2012-11-28" version="1">MIETFAIIPVKKFENSKARLSPMLSADDRIRLSSLMLDDTLSVLAGAQALRQIVVVSGDRRAEEIAARHGAKFLHEQKESGVNAAVMMANRYCMEQGAGATAVIPQDLPLLDAADIAMACDLAEDEDRCIVICPSLRYDGTNLLLRKPPSLIETYYDNDSYQTHIKTAGERGIPVKLFLSKRLMSDLDTPEDARQLAKEASSSKTLEFIKSRLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHM3</accession>
    <name>K0IHM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03300</name>
        <name evidence="3" type="ordered locus">Ngar_c03590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Enrichment culture Ga9.2</strain>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57278">
        <property type="protein sequence ID" value="AFU57278"/>
        <property type="gene ID" value="Ngar_c03300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57307">
        <property type="protein sequence ID" value="AFU57307"/>
        <property type="gene ID" value="Ngar_c03590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03300"/>
    <dbReference type="KEGG" id="nga:Ngar_c03590"/>
    <dbReference type="HOGENOM" id="CLU_2857204_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-330-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="6807" checksum="0C1837CF73FF2F82" modified="2012-11-28" version="1">MIASDSSQTTTRTAKFRNFAMDAEQFIRDNIGLVVFVVFAILIGLALAALFTKPGKKMAAAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX6</accession>
    <name>K0IHX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57507">
        <property type="protein sequence ID" value="AFU57507"/>
        <property type="gene ID" value="Ngar_c05640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05640"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.540"/>
    <dbReference type="HOGENOM" id="CLU_095961_1_0_2"/>
    <dbReference type="OMA" id="DLETCAN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-562-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="23016" checksum="E65545D14712D255" modified="2012-11-28" version="1">MMNSRWVKSESILSSNDDQTISPPKPGGPLKPRLDAVQKKIQVQISRLEELHGVLKSKDEEAFRKLVTSIKENNAQYSTVLSSELARARQVSRVVFLSKVALEKLVARLSSASDFGDLVIVLSPAMAVVKNLRSSLTPHVPEMEGELGVISELLSGILVDAGQVGGYTINFETANEEAVRLIEEASAVVEQKMKDEFPGIPDLPVIPQKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID6</accession>
    <name>K0IID6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57792">
        <property type="protein sequence ID" value="AFU57792"/>
        <property type="gene ID" value="Ngar_c08500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08500"/>
    <dbReference type="HOGENOM" id="CLU_2127911_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-848-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="12667" checksum="5B53CFE23B39BD88" modified="2012-11-28" version="1">MAGGISISDTAKLEAMIHSLGLLITIGKYLPLMIAGFATLNLILAYFDLFVWGHIAPGIFNVILAVVSLIFLGQLLKRRKIHRYEYRYRGRHLNMQPSKKALDRKRAEVAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE7</accession>
    <name>K0IIE7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57817">
        <property type="protein sequence ID" value="AFU57817"/>
        <property type="gene ID" value="Ngar_c08750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08750"/>
    <dbReference type="HOGENOM" id="CLU_2327343_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-873-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="10416" checksum="57AF3E184E4C6088" modified="2012-11-28" version="1">MHGQLALLQRIPGQACGEVMPDFDVIDGWRDELEKMNEGKEGVHHSGTLTLFCTAAGELHAGLFPPAVQTQATVGVVKAHAKKEGVCLLSPTTAPHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG2</accession>
    <name>K0IIG2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58803">
        <property type="protein sequence ID" value="AFU58803"/>
        <property type="gene ID" value="Ngar_c18710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18710"/>
    <dbReference type="HOGENOM" id="CLU_2857211_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1869-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7014" checksum="76964D2A3ABCDEFB" modified="2012-11-28" version="1">MSTTLVIKLSREFVGGFEVDPLLLVMAASLLITGPGRISIEWDVLKREIWPRGKTLVPAAPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0III0</accession>
    <name>K0III0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58848">
        <property type="protein sequence ID" value="AFU58848"/>
        <property type="gene ID" value="Ngar_c19160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19160"/>
    <dbReference type="HOGENOM" id="CLU_2091377_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1914-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="12952" checksum="D1D93C86DCAAFB63" modified="2012-11-28" version="1">MGLALSYPNLPDVLRKFVLNRAVTDCQFAFGAGIYAAHFHKEAYPKDLFILLHTNAELAYGLGLGFGTIFFYLPEQFQSELDLLIKSNVKLDDGLGSGIGMVMKYLPTEVQERFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK9</accession>
    <name>K0IIK9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28200"/>
    <dbReference type="EnsemblBacteria" id="AFU59740">
        <property type="protein sequence ID" value="AFU59740"/>
        <property type="gene ID" value="Ngar_c28200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28200"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="OMA" id="MIVYGPY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2820-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8626" checksum="E653BC62C10B537F" modified="2012-11-28" version="1">MPKAFVLMNAELGSEDSLVNDLKKLDSVKEVYQVYGVYDIVAQVEADTMEKVKETITWKLRKLNGVKSTLTMIVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR9</accession>
    <name>K0IIR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29270"/>
    <dbReference type="EnsemblBacteria" id="AFU59845">
        <property type="protein sequence ID" value="AFU59845"/>
        <property type="gene ID" value="Ngar_c29270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29270"/>
    <dbReference type="HOGENOM" id="CLU_071484_0_0_2"/>
    <dbReference type="OMA" id="CKNANDY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2927-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="30761" checksum="21588D79AAFA7ADF" modified="2012-11-28" version="1">MAAKMDEFKVTNPGLDIENSLTAELQKLDLTLNEARILLFLMTHGNSTASDVSRHTGIQRTETYNYISTLLAKGVVFSTFDRPQKYYALPINEVIDCLVQTKQNALQSIAEKKKDYQEMVEAILSNTVIPESDKKESYQIVMGENSINAKIKRMLAEAKEEVTVLVTDRNLVNMYHAEITDQLIQLTSKGVRVKLRTPCKNANDYISTEDGEKAPISLKTTAKVVPVNFVLVDNKDIILLLESNSFKKSELCGFYTNNLSMISVFTFIFDNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU1</accession>
    <name>K0IIU1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59880">
        <property type="protein sequence ID" value="AFU59880"/>
        <property type="gene ID" value="Ngar_c29620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29620"/>
    <dbReference type="HOGENOM" id="CLU_2257459_0_0_2"/>
    <dbReference type="OMA" id="QFREHAR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2962-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12962" checksum="433B922B1E12E82D" modified="2012-11-28" version="1">MCEFIITDIMPDYFEIDRLVEDLAKIYSTACATSWFKVTGNKRPTKEEFRSKVVEFMKHFEYTLGTFPQTPAADQFREHARKSLEGEIAHVLAGENKDVEKRYKYYVDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ0</accession>
    <name>K0IIZ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoN</name>
        <name evidence="7" type="ordered locus">Ngar_c11610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11610"/>
    <dbReference type="EnsemblBacteria" id="AFU58102">
        <property type="protein sequence ID" value="AFU58102"/>
        <property type="gene ID" value="Ngar_c11610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1101"/>
    <dbReference type="HOGENOM" id="CLU_007100_1_5_2"/>
    <dbReference type="OMA" id="FYIRVIV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="129"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="505" mass="53511" checksum="2F0C0FB9CBC6E208" modified="2012-11-28" version="1">MVDLFSTPILVTVILGVVGLAIPAIDAARREKGKDRNKVYSAIAFGALALAIGIVIFRIFSGEVLPAVAFSQEVLVDDMFGSFFAIALLLVSIMVTASSWNYYKGKSNPAAYYSLILLSSIGMVIIAYSTDLVMLLVAWELMSLPTYALAGFTKRDPISNEAAIKYFMFGALSSALIVLAIGLVYGITGTTNIGDSIRAMANLDADLVPVGLLAVALFIAGFGFKMGLVPFHMWLPDAYEGSPTTIGALLAAGTKKAGFAAALRVIVLGMFALNLDWTLTLAVVAVFTMTLGNLGALIQKSVPRILAYSSIAQAGYIMIGIALAPYSDQALSGSLFHIINHAVMKSAGFIAAAAVATALASYSLEKYRGLGRRMPITAIALSISLLALAGVPPLNGFWSKLVLFGAGINSGPLVEWGPWLAIAGVLNSALSLGYYAWIMRKMYMEEGPDMSKVKEPRAMVAVLVFAMVFMVGFGIWHAPLLDFASRAIPDLTSSITQASFMSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ5</accession>
    <name>K0IIZ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59068">
        <property type="protein sequence ID" value="AFU59068"/>
        <property type="gene ID" value="Ngar_c21380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21380"/>
    <dbReference type="HOGENOM" id="CLU_2204197_0_0_2"/>
    <dbReference type="OMA" id="HIEYEEF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2136-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12313" checksum="4D6B4C9873BD3D36" modified="2012-11-28" version="1">MKFEFEEFATIEDVFLYLVSVAPYMKQVMPISSYKGYVFSIVPLTPLSGEVLMMIYTKGKLEPGLVEFDVSTKKFRPVSAVERADRNYFIVLTPKVATLADEAIKAMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ95</accession>
    <name>K0IJ95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c31690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31690"/>
    <dbReference type="EnsemblBacteria" id="AFU60085">
        <property type="protein sequence ID" value="AFU60085"/>
        <property type="gene ID" value="Ngar_c31690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31690"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3148"/>
    <dbReference type="HOGENOM" id="CLU_2127914_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3169-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_lid_3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="12512" checksum="3D3ADBC7C6ECBCE6" modified="2012-11-28" version="1">MRIHTRKKPLADDVNVDDLAAKTDGYTGADIAAVASAATMLALREHISKYTEAQEAEKNAKELKIHMQHFEEAMTKIRPLSAQELDMYKKIAERFGRPSPPTTTTRASTNAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK3</accession>
    <name>K0IJK3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60205">
        <property type="protein sequence ID" value="AFU60205"/>
        <property type="gene ID" value="Ngar_c32900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32900"/>
    <dbReference type="HOGENOM" id="CLU_2313879_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3290-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11610" checksum="8E5F5856D368CD0E" modified="2012-11-28" version="1">MMNNEIDVDKLFGIVASEANLIKARGRALAMQLQLEQEGRKRFESYNVTCMCPYTMLIIFWKALIRNGCKSCFEIMIQLSMLQSFLIVWPWHYHQCKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJR6</accession>
    <name>K0IJR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58517">
        <property type="protein sequence ID" value="AFU58517"/>
        <property type="gene ID" value="Ngar_c15840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15840"/>
    <dbReference type="HOGENOM" id="CLU_149772_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1582-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="14385" checksum="D3DBF57B3619F59B" modified="2012-11-28" version="1">MSEVVEIKDQFLELQQKYWQYLPKVDPALIDDLLLRQMENPNVVPMYLVEVFTKPGLNVEVRSYIIGKTGMSLAIYDNYTHYVTNQKLTLEMLRDIRLGVIEVTDEFTGGLGNHRRHRQASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJW1</accession>
    <name>K0IJW1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58557">
        <property type="protein sequence ID" value="AFU58557"/>
        <property type="gene ID" value="Ngar_c16240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16240"/>
    <dbReference type="HOGENOM" id="CLU_3039178_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1622-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6165" checksum="1057B394CE4BE433" modified="2012-11-28" version="1">MSQDTTIQSEPIRKLFQGKNFGFLAMLIPDGPPQVMPTLGGYREQPHYYQYCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJX8</accession>
    <name>K0IJX8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58577">
        <property type="protein sequence ID" value="AFU58577"/>
        <property type="gene ID" value="Ngar_c16440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16440"/>
    <dbReference type="HOGENOM" id="CLU_1682754_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1642-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="17536" checksum="0A632473238A9DA8" modified="2012-11-28" version="1">MAFEGPEKRKKLISSMVVLAALIGGAIFATAALSIYFRSQDPVNQCIEDPTSQPFQLSVPITVTEDGFPALVPRGIGIDDNCIRPVHTLQENVIHVAYSRPHDFTLGHFLYYWLGNDLLQYNTKVFVNDVQHTEGDIRDIILMEGQSIRIEFTSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ1</accession>
    <name>K0IJZ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glutamine synthetase</fullName>
            <ecNumber evidence="2 5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA2</name>
        <name evidence="7" type="ordered locus">Ngar_c35220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35220"/>
    <dbReference type="EnsemblBacteria" id="AFU60435">
        <property type="protein sequence ID" value="AFU60435"/>
        <property type="gene ID" value="Ngar_c35220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3525"/>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_2"/>
    <dbReference type="OMA" id="VFPWESK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="126"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="495" mass="55933" checksum="3B60A1DD94379028" modified="2012-11-28" version="1">MPTDGIFQLPYKLVDGRIEPLTFTADQVMSRLKEDKIKFLDLQFTGLFGRFHHTTMDSKMFRAEDFTDGLPKLDGSSIRGFTEIHESDLIIRPDPSTFATVPWIGTPTARLICDILSGGSKREIFPRDPRGIAKRAEQYCIDQGFDTSYWGPEVEFFVFDKLEVNTMTPYQGQSYHIQSREAPWSTDSVGYALRLKEGYLPSAPGDTLMEYRNECVDVLTNNFGIVCDAHHHEVATAGQCEIDIRFDTLVNAADAVQSYKYIVKNIAKKHNMIATMMPKPIALDNGSGMHVNVSLWNKGKNLFYDFADEYAEMSQTARYFGGGIIEHAQALAAIVAPTTNSYRRLVPGYEAPVYVAWSTGNRSAIIRIPAHYKGPKFANLKRIEFRAPDPSCNPYLAFSAILAAGIDGIKKKRDIGDPVNEDIFKMSPKRRREFGITQLPASLREAYEELESDNAFLKPVFDSETIDRIIEHEEKEHVELAVRPHPHEFSMYADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK32</accession>
    <name>K0IK32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetate--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c26620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26620"/>
    <dbReference type="EnsemblBacteria" id="AFU59583">
        <property type="protein sequence ID" value="AFU59583"/>
        <property type="gene ID" value="Ngar_c26620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2637"/>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_2"/>
    <dbReference type="OMA" id="SFMSQSG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2662-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="492"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="700" mass="75658" checksum="7129AE06A5BA4961" modified="2012-11-28" version="1">MSNSIFFAPKSIAVIGASEKPGVGKTIFNNIAKHFKGKIYPVTPSNPTVSGLTAYKSVLDVPESVDLAVVAAPSRFTPAVMEEVGKKGIKGAIIVSAGFKEVDEAGAKLEKEVGEIAKKYGIRVIGPNCLGIMSLSANNMMNSTFLKITPKHGGIALVSQSGAICAATVEDAEAQNIGFSKVISMGNKVDMDESDVLELLAEDQDTRVIVMYLEDIRNARRFMDIARRITIERRKPIIVLKSGRTAEGAKAAASHTGALGGSDANYEAAFAQCGVIRVDTMGELFDLATAFSKQPLPDGGVVIVSNAGGPAIISTDACSRYGLKMADISSIRDDIAKVIPAYGSPRNPVDIVGDADYIRFENVLNLVLSHPNVGSVVTMCTPSATLNYDDLARVLVKMSKQFPNKTILASLMGLAEGIENRAIMSEGGVPYYLYSEPAIRTLKAMYDFKQWVDTASTKAPMLQFAKDKNKVKYIFDNVRKQGRTNLLEEEGYEVLRAYGFPTPKSILGTTEEECIRAAKEIGYPVVMKIASPDIIHKSDAGGVKVGVKNDDELRQAFRSIVESAKKYKADAKIKGVLVQEMVKSAKETILGASQDPTFGPVIMFGLGGIYVEVLKDVVFRVAPIDEREATKMVESIKTIKLLKGVRGEKPSDLKAISDSLQRLSQLVVDFPEIKEFDINPLLVLEEGKGARVVDARIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK87</accession>
    <name>K0IK87_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17790"/>
    <dbReference type="EnsemblBacteria" id="AFU58712">
        <property type="protein sequence ID" value="AFU58712"/>
        <property type="gene ID" value="Ngar_c17790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17790"/>
    <dbReference type="HOGENOM" id="CLU_184184_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1777-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="7813" checksum="B79761693F8186EF" modified="2012-11-28" version="1">MDVPFSSSAEAKAVVKALIPDNVNFPKGLSMRIFSKGATLAIQLTGKNVPAATVLSTLDEVLEHISISKKVMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH7</accession>
    <name>K0IKH7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cdc6</name>
        <name evidence="5" type="ordered locus">Ngar_c20100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20100"/>
    <dbReference type="EnsemblBacteria" id="AFU58942">
        <property type="protein sequence ID" value="AFU58942"/>
        <property type="gene ID" value="Ngar_c20100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20100"/>
    <dbReference type="HOGENOM" id="CLU_025112_3_2_2"/>
    <dbReference type="OMA" id="YLFYENE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc6_C" evidence="4">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="398" mass="45307" checksum="7882A4CBF9CE0E81" modified="2012-11-28" version="1">MTNNIVQDILQKHTVFKDESVLDVEYTPDSLMHRGRELGSLALFFRPLLETPGKASPVALIYSRSGTGKTSITKTFGGIAADMLKSKGIDLKYVHINCKFVTNMHALMQQIVRSTTGADVKGLSPDLMFREMYRQLDANNKYLLLTLDEVDWFIKRTGEDLIEQLTRYREELSRPKRLAIIFVIRDSNIDTMAELERSKLHRTFGARMLKLEPYTKEQLVDIIGQRVQMAFRTDGSVPDNIIDFIAEMACSIGDAYYAIQILWKAGKCADNFGMDRVIPEHVRMAKSMTDPKVRSEDLLSLPRDEKVVLQAVANLLRKESNIYVNLSDITETYHVLCETYRSKPADNRSVREYLLDLSRIGFLDIKNAKSKLEASIHDVPIGILLEVLEPMVAKEHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKN5</accession>
    <name>K0IKN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21310"/>
    <dbReference type="EnsemblBacteria" id="AFU59062">
        <property type="protein sequence ID" value="AFU59062"/>
        <property type="gene ID" value="Ngar_c21310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21310"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2115"/>
    <dbReference type="HOGENOM" id="CLU_1105239_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2129-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="238" mass="26082" checksum="994FD1010F281B0A" modified="2012-11-28" version="1">MTAANETRINEWFVPKFGPIRFRVFVGLLFLPYTGMCISFTIIGSMLAGEIAWDRVGAIALIYALALGVSAHVADSLGSKKTKPWGSYFTRAQLLALMVATLAAAYAIGIYYIAFFVPLLAVIAALEGFFLFAYNFEAFGGRFHNNFWFAVSWGTLPALAGYVMQTDSINNILALAVSGLTGLVSYAEIRMSRPYKKLKQNGNNPEQAKKLENGLKIISLATIAFALALVAYRMIIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR5</accession>
    <name>K0IKR5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59122">
        <property type="protein sequence ID" value="AFU59122"/>
        <property type="gene ID" value="Ngar_c21920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21920"/>
    <dbReference type="HOGENOM" id="CLU_2613755_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2190-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9020" checksum="4A766644A26681F5" modified="2012-11-28" version="1">MPEEKRRRTATGFSTTARSRRSTASAEDVCCKIVRCVHPPEKLRSFWDVRIDSAMKKQGCSIPVVRKIARMKIKEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKZ2</accession>
    <name>K0IKZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60068">
        <property type="protein sequence ID" value="AFU60068"/>
        <property type="gene ID" value="Ngar_c31520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31520"/>
    <dbReference type="HOGENOM" id="CLU_2032935_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3152-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="13210" checksum="448676869C7D9856" modified="2012-11-28" version="1">MQSQKAREYVALSDNLFSVNDKVQYVAIANVLGEIIDIYHNNGANSPSVLSKGRLSEDLRKITLATNVLTFENIRLMVLDTASSKALIINLAEDTIIVGMSKDGVLPDLARVLSCISRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKZ3</accession>
    <name>K0IKZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59227">
        <property type="protein sequence ID" value="AFU59227"/>
        <property type="gene ID" value="Ngar_c23000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23000"/>
    <dbReference type="HOGENOM" id="CLU_2299431_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2298-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11689" checksum="29454425F3110E61" modified="2012-11-28" version="1">MIKSPASERENKNSFMNELPLIDVGESGTSDDPRFQCNICGNRADFVVQLELVKGNMKYNALHTEQMPFYLCKAHEYVYKKMQRSIELKDYFTETIKENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL99</accession>
    <name>K0IL99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <ecNumber evidence="2">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemL3</name>
        <name evidence="2" type="ordered locus">Ngar_c33530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.3.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33530"/>
    <dbReference type="EnsemblBacteria" id="AFU60268">
        <property type="protein sequence ID" value="AFU60268"/>
        <property type="gene ID" value="Ngar_c33530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33530"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3343"/>
    <dbReference type="HOGENOM" id="CLU_016922_1_1_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="259" mass="28362" checksum="B43D662175FEF22B" modified="2012-11-28" version="1">MPAGVTDSIFISNARGSHVLDVDGNEYIDYKLGHGPVILGHGHPAVLDKVHQYDKRGAIYGSDTPLEVTLAEKIRSIVPSAEMIRYHISGTEATMHAIKIARACTGKEKILKFEGQYHGIHDYVSFSTEPGTESRRGTAQPDSIGIPKAIGKLTLVSEWNDFDVVEKTVKKHSDNIAAIITEPIIANAAVIPPRDSYLKFLRELCDKNGIVLIFDEVKTGFRVAKGGAQELLGVKPHLTTPAKSLGNSIPFRRWSGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK8</accession>
    <name>K0ILK8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative adenylyl-sulfate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35700"/>
    <dbReference type="EnsemblBacteria" id="AFU60483">
        <property type="protein sequence ID" value="AFU60483"/>
        <property type="gene ID" value="Ngar_c35700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35700"/>
    <dbReference type="HOGENOM" id="CLU_2230470_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3571-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12000" checksum="92F7AF83FDB7B092" modified="2012-11-28" version="1">MVYRPTIVWQDHSGRSVADKLRELEVKVELLNGDEVRKSLSPDLGFSKKDREAHAQRTAYLYKLLSRNGIASIVSSLISPYRASRQQAREQVVRRMRCKNIALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILN7</accession>
    <name>K0ILN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57174">
        <property type="protein sequence ID" value="AFU57174"/>
        <property type="gene ID" value="Ngar_c02260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02260"/>
    <dbReference type="HOGENOM" id="CLU_2505057_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-226-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9812" checksum="4A369813EDD3040A" modified="2012-11-28" version="1">MEEEVAKRSGEAVFLLWLQYKTITNKMSALPIRTLALLRFHNPTQIGMTVPLYSEQYICLLLDSQIKIISATFVRTKDKETLYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP4</accession>
    <name>K0ILP4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57194">
        <property type="protein sequence ID" value="AFU57194"/>
        <property type="gene ID" value="Ngar_c02460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02460"/>
    <dbReference type="HOGENOM" id="CLU_2534800_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-246-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9320" checksum="280E0FC57C002886" modified="2012-11-28" version="1">MTAGKKKRRREHGADGDDLVEPKKVTGKELSENEELSARLTVLVEMLDEKGVINSNEYRRRVAMRLHEISKAGAIEELDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR1</accession>
    <name>K0ILR1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57254">
        <property type="protein sequence ID" value="AFU57254"/>
        <property type="gene ID" value="Ngar_c03060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03060"/>
    <dbReference type="HOGENOM" id="CLU_2748314_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-306-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7871" checksum="09663EC161A695A4" modified="2012-11-28" version="1">MFGKSGLQWLKSLQLSLIDKVIIMDTSIAAIESINCQIDIVSKEICKYAWDSEDVRIILSMTGKGYSLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU7</accession>
    <name>K0ILU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC uptake transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c27610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27610"/>
    <dbReference type="EnsemblBacteria" id="AFU59682">
        <property type="protein sequence ID" value="AFU59682"/>
        <property type="gene ID" value="Ngar_c27610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2736"/>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_2"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2761-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="319" mass="34818" checksum="432715DD8952AAD1" modified="2012-11-28" version="1">MDMDKKIIVGIAAAAVAVAIAVGVIAISTQPQPLASGDTEKVKVIASFFPLYDFASNVGGDKADVSVIVPAGIEPHDWEPTPRNIADAGNADLIIYNGAGFEGWVAQLNAKNAVDTSRGIELMEGEHEEEGEAKEEGHEESALDPHIWLDPVLAKKQVESIRNGLIQVDSANADYYRQNAQQYIAELDSLDAFIRSELSNCEKTDFIAFHNAFSYFAKRYGLTQHSVHEGLSPEGEVLPQRISEIKQLATSLGINIIYSEDLVDPRLANVIASEIPNGQVLVLSPIEGLDREEQEKGFGYIEKMRQNVENLKVGLKCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV9</accession>
    <name>K0ILV9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59717">
        <property type="protein sequence ID" value="AFU59717"/>
        <property type="gene ID" value="Ngar_c27960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27960"/>
    <dbReference type="HOGENOM" id="CLU_2613758_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2796-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8602" checksum="C31223D8DE30C382" modified="2012-11-28" version="1">MIAKQIATKHVWKLVGIGMIAFGVLIALPIGIPHANDRTGLGWFFTAGVFMIAAGVFIMAAYVDRAVRRHRKKFFEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY2</accession>
    <name>K0ILY2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">asnS</name>
        <name evidence="7" type="ordered locus">Ngar_c04900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04900"/>
    <dbReference type="EnsemblBacteria" id="AFU57434">
        <property type="protein sequence ID" value="AFU57434"/>
        <property type="gene ID" value="Ngar_c04900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.469"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_2"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="127"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="435" mass="49113" checksum="F12F60613358774E" modified="2012-11-28" version="1">MSLRTSQIKSSDYIGKEVTIRGWVYRLRKQKENAFALVRDDRGGVIQCIFPADKVAGLTIESSVEVTGVVSQDARAPEGGYEIKGKNIRVYSVAGTDYPIGEYQSDELLLDKRHLALRTRKMVAMAKIRATVLDLGRRWFVDNGWMEVTAPTIVKGAVEGGSTLFKLKYFDEEAYLSQSAQLYLEAMIFSLGPVWSLTPSFRAEKSRTVRHLAEFSHLEAEAPWVTLEDILQVQEQLVSYIIQKTVKERAEELAFLKRDTTDLKKIEPPFERLPYDKAIEILRSKGFTVTEESGTKREIRAGDDLNIDSERELTKDASKPIFVIGYPIAVKPFYVKEDPERKGVGLAADMLAPRGFGEITSGGLREDDIVSITERIKKEGLNPAAYDWYLDLRRYGSVPHGGFGLGIERLMRWITNADDIKDTVLFPRTMSRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY3</accession>
    <name>K0ILY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59792">
        <property type="protein sequence ID" value="AFU59792"/>
        <property type="gene ID" value="Ngar_c28730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28730"/>
    <dbReference type="HOGENOM" id="CLU_1084236_0_0_2"/>
    <dbReference type="OMA" id="HAHMTID"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2873-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="256" mass="27658" checksum="7A28C8A5795D38ED" modified="2012-11-28" version="1">MKATLFGSITMAAAIAMLLAVPAAYNAIAFPHAHMTIDPEQENANPISVVIGHSDEPAYGVRTAIHNGKHNVEVLLEDAATALPLSGATLKVDKYYFANIDSFNRASSPSNADRVEENATLSEVFGEPGHYVNRQIVREGIYGYRVYGTIDYFGVAEVPIDSTVFCSSAEGDTSKFNSEGWGGGFGCPENINDIRFPLRPVQSSSSSSSVNPTALEEDGRGQQQQYQLLAMGLPVAGLAAFLGIRQWKHKKNDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ3</accession>
    <name>K0ILZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57459">
        <property type="protein sequence ID" value="AFU57459"/>
        <property type="gene ID" value="Ngar_c05160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05160"/>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-514-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="230"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="441" mass="49553" checksum="35546104F86F385D" modified="2012-11-28" version="1">MRTAMKANVVHMDLNPCGGAEQVAIATIQALVEMDIDVELTTARIPDISRLKKAFGSERIDAFYHRIRRLNLFHRLPVESKDRDAADDEVVTINTHGDMLPYYLSTFSSSNAITYCHYPLVTEFSRVHDLAYLQYLRDLGLIKMDGARAGSNNDMRSRTQNSVSRLWQELEESYLAMLKHSTIVTNSTFSRDAILKVLSRAPYGNNNIAATRSMADPIVIPPPVNVEEFRRAALYSRERDNFIVVISRFNPSKKLENAIALAHVLKKLKIGKKMIIVGGLMPEDRNYHDHILRMIKSCDLSDYIALEVNATSDILKSIMRKAKVYFHPMPGEPFGISIAEAMSAGLIPIVPDIGGHTDFVPEKYRFSSLEDAAMKISSALNASQEEREKVSDIVSPFSFDRYIESIQGIIGAILSKEQVRHKTDLDAYQKARQDFHGTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM57</accession>
    <name>K0IM57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent glucose-6-phosphate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.98.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06360"/>
    <dbReference type="EnsemblBacteria" id="AFU57579">
        <property type="protein sequence ID" value="AFU57579"/>
        <property type="gene ID" value="Ngar_c06360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06360"/>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_2"/>
    <dbReference type="OMA" id="WRHKGGH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-634-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052749">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase (coenzyme F420) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="343" mass="38523" checksum="B2254A32C4C89167" modified="2012-11-28" version="1">MGYWAAQEQYSMQDLLKFVTEAEKSGFATTMTSDHFHPWWHDGAFGNFTWIWMAAAAENTKRMQFVTGVTAPVYRYHPAIIAQAFASLDVLYPGRIGLGLGSGEAMNEAPLGFDWPRARARLARTKEAIQIIKELWGQGVDDEGFVNFNGEYFLIRDAKLYTPPSTKIPVYMAATGKQAAKVAAQYSDGLITYLPAAEAGKVLHIFDATAEKEGRDKDSLEKIAEYKVSFSEDYDEAFKSATFWRATLIKNVFDSDISDPRSLQQKAESKVPDEKIKQAIQITTSIEDCIKSIEDYFKVGFTRVYVHSTSPDEIKFIQMFSKKVMPHFSIEARGSRKTTATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA3</accession>
    <name>K0IMA3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">gatE</name>
        <name evidence="8" type="ordered locus">Ngar_c07460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07460"/>
    <dbReference type="EnsemblBacteria" id="AFU57689">
        <property type="protein sequence ID" value="AFU57689"/>
        <property type="gene ID" value="Ngar_c07460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07460"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.720"/>
    <dbReference type="HOGENOM" id="CLU_030702_0_0_2"/>
    <dbReference type="OMA" id="SGFQRTM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="485"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="632" mass="69336" checksum="32D09E272E205539" modified="2012-11-28" version="1">MTTIDPASLDLKVGFEIHQQLATKSKLFCNCSCEEAQKYDHSFVRKLRPTQSELGAYDPAAMFEFSKMRTVEYHAALGSSCLVEADEEPPHDVSREALEIALIFSLALHSKVMDEVHVMRKLVIDGSNTTGFQRTMLVASGGYLDVAGKRVSVQSICLEEDAAKLIGDDKGVRKFGLDRLGVPLVEIALEPVTGKPDEIMQVALTLGRLLRASKRVARGLGSIRQDVNVSVQNGAVVEVKGVQQLDQLVKVIEHEMQRQHGLIVIAEKLKERKVDVSKVGDRIEDVTDILGKAQSKIVKKILDGGGLFRAIRVPEFAGMIGYEPYQDIRIGKELGKLVRFYDLDGVFHSDELPNYGITEQEVAAVRSRLQAGSSDAFVIVGGPKDKVGFASDAIIRRLQAAVDGVPAETRAATPDGKTVFLRPRPGAARMYPETDIPTIPITDSMLKALEEKVPRSWDEIVDGLAKKYSLNKKLASQIFDSDYLGVFEEIAGTTKVQPTFVASKLTEDITSLQRQGLDPSVLTDDIIKDVFARLDAGAIAKESVNIIFEKLMKKEVKNIDEAIKIAGVASISDDELSRGLDRIISDNMAVVKEKGMNAQSALMGRAMAEYRGKADGQKINAMVRDKLQKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB9</accession>
    <name>K0IMB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57744">
        <property type="protein sequence ID" value="AFU57744"/>
        <property type="gene ID" value="Ngar_c08020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08020"/>
    <dbReference type="HOGENOM" id="CLU_2230460_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-800-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11877" checksum="74A2D0DEB4CD04B2" modified="2012-11-28" version="1">MNDSKSVRNEILHLVALIRDLRATLLQEKQSDVSVSSSLLPLGSRTEANIDITIQILDIAERVVDTYTRLKDYRDAEFKILARPTLFWPDGRSLGFGFAAHMCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF4</accession>
    <name>K0IMF4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57859">
        <property type="protein sequence ID" value="AFU57859"/>
        <property type="gene ID" value="Ngar_c09170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09170"/>
    <dbReference type="HOGENOM" id="CLU_2597498_0_0_2"/>
    <dbReference type="OMA" id="RTMSGQK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-915-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8594" checksum="EB0B4785602554C6" modified="2012-11-28" version="1">MAAKVRVKAKRWGSSLGFIIPNEVVKEQKIREGDELEIELQKVSNIEKLFGLAHGKRPAGLTTQKIKDELRAGWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP6</accession>
    <name>K0IMP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35490"/>
    <dbReference type="EnsemblBacteria" id="AFU60462">
        <property type="protein sequence ID" value="AFU60462"/>
        <property type="gene ID" value="Ngar_c35490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35490"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3550-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11188" checksum="10D83683E1864CED" modified="2012-11-28" version="1">MVFVEREKISMTQALIFVNCDTNNQETIRDHVSQIKGVLEVHMTTGIYDLILKAETESEEKLREDVIRQIRKIGGIRSTTTMIVFKPDAAVPAAGDALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ7</accession>
    <name>K0IMQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60492">
        <property type="protein sequence ID" value="AFU60492"/>
        <property type="gene ID" value="Ngar_c35790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35790"/>
    <dbReference type="HOGENOM" id="CLU_2857221_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3580-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7120" checksum="A7BE2484ED2B0F61" modified="2012-11-28" version="1">MGNQDKAGTKSFDDADTFCRACETELKAMAVCIKCGNAMLYGCPRCALFSETKVHIDCLYQLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU6</accession>
    <name>K0IMU6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13010"/>
    <dbReference type="EnsemblBacteria" id="AFU58239">
        <property type="protein sequence ID" value="AFU58239"/>
        <property type="gene ID" value="Ngar_c13010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13010"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1248"/>
    <dbReference type="HOGENOM" id="CLU_1639891_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1299-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16011" checksum="91D11999946C8E48" modified="2012-11-28" version="1">MTGKEIIDKATVQSDGKWKPSPGLIYPLLGRLLDEGLVTEDKDGRYAITKKGLEITSDLESFGSIIQKQIDVMLRVGNVGKFMAMDLIDRVTMIGSALSSNLDAMTQEERNKYREFLQSELKKLDEQQSKDAAAAATKEKVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW3</accession>
    <name>K0IMW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPPG:FO 2-phospho-L-lactate transferase</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cofD</name>
        <name evidence="3" type="ordered locus">Ngar_c13870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13870"/>
    <dbReference type="EnsemblBacteria" id="AFU58324">
        <property type="protein sequence ID" value="AFU58324"/>
        <property type="gene ID" value="Ngar_c13870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1348"/>
    <dbReference type="HOGENOM" id="CLU_055795_1_0_2"/>
    <dbReference type="OMA" id="DLDTVMY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="306" mass="33690" checksum="899093E2BDC51B3E" modified="2012-11-28" version="1">MITVLAGGTGSVKLVRGLAKSAKDMTIISNVGDNIWLYGLYVCPDIDTIIYGLAGELDEQRGWGIKGDSFECLAQLKRLGAPAWFGLGDRDIAIHLQRTSMIKNGKSLSEITSWMTDRYSVAAKVIPATNSEVTTRIITSRGEMHLQEFWVKHRGMPRVTGVRYDRVDKAVANHDAIDAIRQSDAIIVAPANPVSSIGPIVALADLRKELVQVREKVVAVSPLIGEKAVSGPAVKYMKALDIESSPVGVARYYQDFVGTFVISKDDHRFSSKIEALGMHVHETNITMKSRQDEVRLGRQILSMIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ9</accession>
    <name>K0IMZ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58504">
        <property type="protein sequence ID" value="AFU58504"/>
        <property type="gene ID" value="Ngar_c15710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15710"/>
    <dbReference type="HOGENOM" id="CLU_935735_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1569-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="297" mass="32365" checksum="0461412288111C02" modified="2012-11-28" version="1">MASSAIAKNSKNQVAQVEVEWDKIESVSKALSTIPQDSGELIVKPFGEIDSITLAVALSLTQGAGGSVTAIAINGIKDFQIKDRGNDNIMKIAGARLNHLYHLLTGLTLPVTGTNINASSSGTDTMKFTLPVAIEMPDQPIRIAYEIDTLTNAGNANSTSGSVTIDTYIHYGHTVADKTIRFKEGQTASLGTGEKDIARDLLKEGTITQIALFFPTVTNIAQLYVIFKPDGEITVFDHIDEEALQAMEVLRYPVSGHSVTGLYPLFHKPFTWQEDKTELTVNIADAQEVRVYQFYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN15</accession>
    <name>K0IN15_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58584">
        <property type="protein sequence ID" value="AFU58584"/>
        <property type="gene ID" value="Ngar_c16510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16510"/>
    <dbReference type="HOGENOM" id="CLU_2839484_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1649-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7745" checksum="E2FCF5502AC19A6F" modified="2012-11-28" version="1">MPTVAYKITIELKQKKMTHDELKQASRYLSEALTKIGIDHSVECRMDKLKLFRITRDFLKHRNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN28</accession>
    <name>K0IN28_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58649">
        <property type="protein sequence ID" value="AFU58649"/>
        <property type="gene ID" value="Ngar_c17160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17160"/>
    <dbReference type="HOGENOM" id="CLU_2857210_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1714-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7630" checksum="55E6507B44DD27A7" modified="2012-11-28" version="1">MSKIKFAKHPRSIVRKRQDHPSSLFVTIPVRIVKQWELKGGELVEFEYVKRNEKPVIEIRRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN66</accession>
    <name>K0IN66_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c19070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19070"/>
    <dbReference type="EnsemblBacteria" id="AFU58839">
        <property type="protein sequence ID" value="AFU58839"/>
        <property type="gene ID" value="Ngar_c19070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1891"/>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_2"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1905-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="524"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="680"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="840"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1182" mass="132774" checksum="2039EFA759FD5388" modified="2012-11-28" version="1">MVHIKKLEVYGFKSFGFKNTVVHFEKGLIAVTGPNGSGKSNILDAIMFAIGENSPKALRVDKFQSLFHDSHNSSHRLIRVSLTFDNTDRGIPVDEDSVTLTREMEGQNGESQYSLNGKKVSKTTIMELLEVVLAAPNKLNIVQQGMITRISELNSEERRKIIEDIVGLSYFDEKKAEAMKQLDEADRRLEVAFARMGEIRKRIDELEAERNDQLRYDQIGSELKRFKAVQISNTIRTVRHKLATSTQILESNNMKSSQLSKKVDELRLEIEKLDAEKTKFIQEVDAATRAKAQVASRISSVVHDSERTKAMLGESERRIVEIERRLPAIDSGKQVVAQRMESARAEAEKLKVAVEQKKATMAELRTKLDALDAEIEKITAKVAKYAAFRNKLGKRHARMSALKGQIELAATRVEEKIKTINYKKSSNDAALGALQSEILAAKHRIAEMEKSLENDKKKLQETSGLVAELAEAKAGLEKELAGSASLLIRAESLATKFEERASVAKNAMNEDFAIAELMKEKDKFGIRGLVHDLIMWDKNYERAVLAAGSEWMKAFVVDDIKSMILIAAYAKERRLPRLRIIPFDVVMRFKENRDIPDDDVNVIGKLSDFVQSDYRKLPEFLFSDTLLVRNSSSAFMLARQGYRTVSAEGELFEPAGGSMALDFGGKITDMTKAILFGDSVEELRGMLAKLSKTVEKKNAQLQEIAERIASSEAEKVRLELAIGNLESRIAAEHEAVSAKEKSVSQFVSGNQILQSEADMLAAELGKYSRRLELLVPAIGRLSSRLQSIGDEPSSKSELAAKNLERNQIIKAIDTVNIELGQATSMLAGLEGRLELDTRQLGEMDNEKERLSLELEQRRRQMEELKTKSQSLEAELKGLRDQEQQIIDSSGSAYSVLQEYERKIKAFTENERKLSKEHNIIERESALLRKDIADLTAEESRQTNDLVWLGYKNLLDEMDVGAAIKELTDEYENVKSRINLRADEAYVQVMDGYRGMSTRRNQLESERNSIVSFIEEIVKEKEKVFMEAFQKVDSDIRITFERMTGGAAWLEIENPADVFSSGVMLLVRFPNKTVPRESTALSGGEKTIAATVFLLALQSLKPSPFYLMDEVDAHLDAQNTERLSKVLLERSKDSQIIMVTLKDSTVAKAALIYGVYPKEGASQVVKYKNPAQIPLAQISENKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN96</accession>
    <name>K0IN96_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58989">
        <property type="protein sequence ID" value="AFU58989"/>
        <property type="gene ID" value="Ngar_c20570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20570"/>
    <dbReference type="HOGENOM" id="CLU_1782547_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2055-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="19399" checksum="38B38489E5ABBF4A" modified="2012-11-28" version="1">MHCKAFDQNITYSNQFLDVMPIEWDVLVTEMAMLGTIIYSAIFVENWIAKRKMHLKEKEDGRRTIEFVANDLKKKIRFIDDSVQYKDFKPFFTDMWDAIILGGKQTVLPFELFENLQHTYSWMKYYNNELEQREKGDGEAVVMEILGEVKGSIGQSLKLLKEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA9</accession>
    <name>K0INA9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Methionine aminopeptidase</fullName>
            <shortName evidence="6">MAP</shortName>
            <shortName evidence="6">MetAP</shortName>
            <ecNumber evidence="6 7">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">map</name>
        <name evidence="9" type="ordered locus">Ngar_c21230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6 7">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|1237085.11.peg.2106"/>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="8">
        <location>
            <begin position="69"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="361" mass="40475" checksum="8822434CC56F87FB" modified="2012-11-28" version="1">MHSSNSFIMLTCLWFNIGIDEMTLLAYNDCRDYTSGKYIEQLFRSSLAPHNLYIMSMSTKKHRMNFVERYLQAGRIAAEVRESARKKYHVGSTLFEICESVEAQIRSMNGQPAFPVNTSLNEIAAHYTAEPNDATVVKEGDVLKIDIGVHIDGYIADTAVTVCYDPKYEALVKAAEAALGEAVRMARANTKASDIGRVIESTITKFGLRPIQNLSGHSLQQYTIHAGKSIPNIWTIGSSFTLVPNEAYAIEPFVTTKDGQGAVHEGKIKNIFGITSRKPVKDKEADNLLELIWSRFRTLPFALRWLTDKYDEKDLRRLVDVLIKKRNVHAYPILVEGHSRIVAQAEHTLIPTESGVNVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB7</accession>
    <name>K0INB7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c21640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21640"/>
    <dbReference type="EnsemblBacteria" id="AFU59094">
        <property type="protein sequence ID" value="AFU59094"/>
        <property type="gene ID" value="Ngar_c21640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21640"/>
    <dbReference type="HOGENOM" id="CLU_736967_0_0_2"/>
    <dbReference type="OMA" id="REIRLWK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2162-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="373" mass="42821" checksum="C2EE17AB165AABDD" modified="2012-11-28" version="1">MMGRLFGRDDKKDDDAPSEGRREPDYNDNDFQKRDLYKKGLNHMSNEKFLDAIRSFDLALRLDSQYVDAWIKRGYAHFHLGEYTVAIRSYDRALETDVNNAEAWNLKGLAYYKMKNYEKAIECCEKAIDINPNDGMSWYNKACYLTLSGKVDEGLDALKRSIEIDIQNARKAVRDRDFENARAEEGFRRIVEVVVLESIRQGYDYVGKIVWVTGMDKVEIEDALMRLAMKGLVIKHERKSFTGKEEYYELPKEIADKVGVTKRTGLFSSKQVSAPVQQLKDIKEVLGKAKESIEKGDLASTLQYFDELISPAKHGSAMMEQFFDAHRDLRLYKIRLQDKGQEYLNAHKSDLIDLITKIDHSVGSGVAKPPAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND0</accession>
    <name>K0IND0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoK</name>
        <name evidence="4" type="ordered locus">Ngar_c22290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22290"/>
    <dbReference type="EnsemblBacteria" id="AFU59159">
        <property type="protein sequence ID" value="AFU59159"/>
        <property type="gene ID" value="Ngar_c22290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22290"/>
    <dbReference type="HOGENOM" id="CLU_1860765_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17315" checksum="10281BECCF150536" modified="2012-11-28" version="1">MVVKHSSKKSAAPKKPATTAKAKTKKASAPRPLKKNKKGAASRKQVQELIASKKSSRPADEVVTYPEVEYELKEIEPQGNKVLIGPPWLTRFERARITGSRSLQLSLGAPPLIKVPEQAKSSIMLAVEEIDAKALPISIRRILPNGVYQDIPIDWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF1</accession>
    <name>K0INF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59264">
        <property type="protein sequence ID" value="AFU59264"/>
        <property type="gene ID" value="Ngar_c23380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23380"/>
    <dbReference type="HOGENOM" id="CLU_2550392_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2336-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8878" checksum="E8D6E74CC987C0D2" modified="2012-11-28" version="1">MNIALIEKSSKGLKLNLYSETLAPIESESFDDLYTLNFHLQTLAKKHRIEKGLLVVHDKDRNAVNLSITLDENSFFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ2</accession>
    <name>K0INQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28490"/>
    <dbReference type="EnsemblBacteria" id="AFU59769">
        <property type="protein sequence ID" value="AFU59769"/>
        <property type="gene ID" value="Ngar_c28490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28490"/>
    <dbReference type="HOGENOM" id="CLU_1514543_0_0_2"/>
    <dbReference type="OMA" id="WPEQNAT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2849-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="177" mass="19992" checksum="C79F8A5CBEB5D17D" modified="2012-11-28" version="1">MVNKFLIAIAGIVVVMAVLVAMPSIGSNQDATELRIKYVRDHIAKMESGILDVTTSEVLRIENDGSATYSRTDSYPTMITTDERRFSLNSDEIKRLKALIFETGFMQIPVSKYDEREGLANYTRYQIVVHQGDDNDQKPITWFNQEASQVPVPSIITNIGSQLDAIIERHIRLTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS0</accession>
    <name>K0INS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative CRISPR-associated protein Cas1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="8" type="ordered locus">Ngar_c29410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29410"/>
    <dbReference type="EnsemblBacteria" id="AFU59859">
        <property type="protein sequence ID" value="AFU59859"/>
        <property type="gene ID" value="Ngar_c29410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29410"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2916"/>
    <dbReference type="HOGENOM" id="CLU_2433968_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10288" checksum="B870614D5DD9EB59" modified="2012-11-28" version="1">MLSGFLIVKQVEHYLDPQKRLAIAKEFVGTAIHNILANLEHCRKNKKDVAQFIDKLKTSMLPLKKSQIYSNSWASREGHKISIIPLLANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW0</accession>
    <name>K0INW0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-isopropylmalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31430"/>
    <dbReference type="EnsemblBacteria" id="AFU60059">
        <property type="protein sequence ID" value="AFU60059"/>
        <property type="gene ID" value="Ngar_c31430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31430"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3143-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8714" checksum="37680E6245920F41" modified="2012-11-28" version="1">MTLAFVFVDCAQHQHSASIGRALREVQGVLEVYSTTGVYDLIVKVSADDETKLQAIIASIKSVSGVMSAITNIVYSAHEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP25</accession>
    <name>K0IP25_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34690"/>
    <dbReference type="EnsemblBacteria" id="AFU60384">
        <property type="protein sequence ID" value="AFU60384"/>
        <property type="gene ID" value="Ngar_c34690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34690"/>
    <dbReference type="HOGENOM" id="CLU_1773262_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3470-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="15520" checksum="600F01FC476770BF" modified="2012-11-28" version="1">MRFFRGSRKQQGFSQNNAALASTDDNQTAQDEIEEQQDEQQSSNSMSSFSSDAEIPSTDNNTKSNDDNGSDSSSSGAEENQPPIANAGDDLTVNERETVTLSGVGSTDPDNDSLRFSWKQTVGEPTISLDGSNADTATFQAPAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP49</accession>
    <name>K0IP49_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="3" type="ordered locus">Ngar_c35910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35910"/>
    <dbReference type="EnsemblBacteria" id="AFU60504">
        <property type="protein sequence ID" value="AFU60504"/>
        <property type="gene ID" value="Ngar_c35910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3599"/>
    <dbReference type="HOGENOM" id="CLU_675459_0_0_2"/>
    <dbReference type="OMA" id="GMCTTYL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF1743" evidence="2">
        <location>
            <begin position="143"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="432" mass="47356" checksum="7FB12D721E38E469" modified="2012-11-28" version="1">MHVQTLHVAFDDTDSRTGRCTTHLAFKVVEHLKKEEGAKLVDYPLLIRLNPNIPWKTRGNGAVCLRLQVQDAGRVIDHIRQAVEEGSAIGSGANPGVAFLQSDSVPAELQKFSALAMCDVLSRQMAEKVAKAAGVQYSTFGNGQGLVGSLGALGCLLDGDHTYELIAYRKPENCGLPRVVDKERVIKFSADTYPNTFNNYDRNHGRVLITPHGADPVFFGVRGESPEVVASALPALQPLEEELDGWTIFRSNQGTNMHLQNEIRVAGAKAYTAGHVKCRVSGKPYAIEGGHVIFTVEQDDGAEMPAAVYEPTGLAKVAIKLEAGDLIEIGVGVRKGTTKHPKILNVEYLSVLELAPAFDVLNPVCKMCGKRMKSEGRNKGYQCDRCKHRDVNAKKIFVPREREIKTGLYIPTPKAHRHLTKPLQRYGIEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6R5</accession>
    <name>K0I6R5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cdc6</name>
        <name evidence="6" type="ordered locus">Ngar_c00010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00010"/>
    <dbReference type="EnsemblBacteria" id="AFU56951">
        <property type="protein sequence ID" value="AFU56951"/>
        <property type="gene ID" value="Ngar_c00010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00010"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1"/>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OMA" id="DMLGIIN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="56"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="314"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU56951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="406" mass="44976" checksum="307B54F504AD07C7" modified="2012-11-28" version="1">MSFDIDSIFDKAASGKSLVKNRQALTIDYVPEKLPFRDEEAKTLAQVLSTVFKGARPSNLLLFGKPGTGKTAVAKNVVDRLQKKSNELKIDVTVIFINAKAAGSAYKVLFEIAEDLGINKEEQGKQVHFTGLSMGEATDRILQYIQKKKLHFILVIDEIDSLVDKSGDDILYNFTRANQRMMSKGGFVTLIGISNSLTFKDKLDPRVRSSLSEEETVFNPYTVDQLRQILQERSKLAFNEGAISDAAINLCAAMAGREHGDARKAIDLLRVAAELAEREGATRVDEKHVRAGQDRMEKDAPFVALKNAPVHHKLVIIAVTKSKSGTTGDVYDTYLTLCKQVEQKPLTQRRVTQIISELELLGLVSTDIVNQGRYGRSQKIKITIPMTTVKEALKEDFASLITTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0I787</accession>
    <name>K0I787_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glucose starvation-inducible protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57121">
        <property type="protein sequence ID" value="AFU57121"/>
        <property type="gene ID" value="Ngar_c01720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.171"/>
    <dbReference type="HOGENOM" id="CLU_2204189_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-172-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="11133" checksum="D7BF92C45A484720" modified="2012-11-28" version="1">MASADEETKERVARKGGEARAQDPESLAEAGRKGGEAVVEKYGPEHMAEIGRKGGESVSQDTEHMAEIGAKGGQASDGGREGGGSERGFAAMSEEERKRIASKGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7M2</accession>
    <name>K0I7M2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57251">
        <property type="protein sequence ID" value="AFU57251"/>
        <property type="gene ID" value="Ngar_c03030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03030"/>
    <dbReference type="HOGENOM" id="CLU_1302661_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-303-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="24401" checksum="40F8DA7CFA7C9978" modified="2012-11-28" version="1">MAQTFVRRKSRLRVKGLKVKDREKVKEAIAISIQNGNYTTRDIGVDVGKDHSTISRYLAEMEREGGWGIKRDTNGNIVVSLQKQLAQQYRQLDKEPFNQLPSIQKWITFLKSGKTPASRIRYVVSVVYGISNQLKVMPETIISYGIPIDAAKRKEIAIEYWQNFLAWFNTAYPQMQRTNTINAYRSFLAAHNINFAHGEGKRYVCQLRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7S9</accession>
    <name>K0I7S9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2 6">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">purM</name>
        <name evidence="9" type="ordered locus">Ngar_c03730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03730"/>
    <dbReference type="EnsemblBacteria" id="AFU57321">
        <property type="protein sequence ID" value="AFU57321"/>
        <property type="gene ID" value="Ngar_c03730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03730"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.360"/>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_2"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="61"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="180"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="354" mass="37903" checksum="27DE47C353F893B5" modified="2012-11-28" version="1">MKKKGGGVTYRDAGVDVGKIRTAQKSIGEIISATHRMAAAGKVVSGFGHYAGLIKLGRELLALHSDGVGTKVLVAQLMNKFDTIGIDCVAMNVNDVICVGAQPVGFIDYVALRQPNEELLQEIAKGLVEGARQSQMAIVGGETAILPDVITGEGENAFDLAGMVMGVVVKGKPILGSAIKPGDVILGVESSGLHSNGYTLARKVLLSKYSVDDNAEHLVQTVGEELLIPTKIYVRPVMEIIKKKKIKVHGLANITGGSFTKLSRLNVRVRYDLDDLPAPTGIFRQIQVDGEIESREMYRTFNMGVGFCVIAPKASTDDIISVFAKYKMHCRAIGRIEKGSGEVAAKIDGRKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I817</accession>
    <name>K0I817_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57416">
        <property type="protein sequence ID" value="AFU57416"/>
        <property type="gene ID" value="Ngar_c04720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04720"/>
    <dbReference type="HOGENOM" id="CLU_1444714_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-470-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="21411" checksum="88CCCFB001D7C8EE" modified="2012-11-28" version="1">MYDPSPDVPKFIIATHLVPVSLPASLYESSLGYLQEKITEISYKYPQFRAELGRGGILDLDIHGKPLSLLHLGLSDGRSNSQVEVTRQTIENALSIYDRNMDNTLAIWQDAFPGDGKLDFSGTAPEQRRIAGYIYHHGPATREQMYEALKNEMSRDSFYRWWKDLYDHGGIYEKVPGIFDIVPHYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I853</accession>
    <name>K0I853_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 5 10-methylenetetrahydrofolate reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05070"/>
    <dbReference type="EnsemblBacteria" id="AFU57451">
        <property type="protein sequence ID" value="AFU57451"/>
        <property type="gene ID" value="Ngar_c05070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05070"/>
    <dbReference type="HOGENOM" id="CLU_1113833_0_0_2"/>
    <dbReference type="OMA" id="NCINIGF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-505-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="265" mass="28489" checksum="5B60492E796FAE82" modified="2012-11-28" version="1">MPDVDFGYTQAMKISYELNPPKIVKGERFNLAQLNADMEAMAGRASQLSGLVSGIHLTDSVLGIPRVSSVTAAGYIKGRLDAGSLSCSVRVRDRNFTSLCQTVSDAIMTGVDSMLVLMGDDPADGPSDSGLRPSAAVKMLRKEGYSSNIKLDLSFPAKVHDRSAKSIQSKLEAKPHSFVTQSISSLSDLGEIVDLAKPYGIKVAAVVMVPAEKNRHSASIIGLDWSEYEKDPADFVRQTAKIADRVLLTSPNSFGSGLELLRQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I898</accession>
    <name>K0I898_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57496">
        <property type="protein sequence ID" value="AFU57496"/>
        <property type="gene ID" value="Ngar_c05530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05530"/>
    <dbReference type="HOGENOM" id="CLU_2949418_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-551-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6821" checksum="23F5C2616E56F985" modified="2012-11-28" version="1">MGEQKDKTLEQVSDEDYKVAPTSADERHLNKRDMKKRVTGESYPLLEEKVQQELRGGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I910</accession>
    <name>K0I910_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57766">
        <property type="protein sequence ID" value="AFU57766"/>
        <property type="gene ID" value="Ngar_c08240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08240"/>
    <dbReference type="HOGENOM" id="CLU_2476117_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-822-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9992" checksum="11B8BC4DBDDC2F15" modified="2012-11-28" version="1">MKQDQIHFRAEFTIEDGKIEEYKELVQDMSRLVKANEPDTIGYQFYLNRDETKCIVHETYANSEAVLAHNTGIASQTILPKIFSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9M5</accession>
    <name>K0I9M5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elp3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c10790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10790"/>
    <dbReference type="EnsemblBacteria" id="AFU58021">
        <property type="protein sequence ID" value="AFU58021"/>
        <property type="gene ID" value="Ngar_c10790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10790"/>
    <dbReference type="HOGENOM" id="CLU_015525_2_0_2"/>
    <dbReference type="OMA" id="CEFGCPY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1077-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="6">
        <location>
            <begin position="30"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="313" mass="36143" checksum="E101CBB00B2040D2" modified="2012-11-28" version="1">MSDLWYSGAATLEEKKSKSIIHPFTVKSYNGLAINPYQGCGHRCAYCYATYEWSPEFYDKIYAKSNASEVLDRQLAEWKSDTIEPVMVASATDAYQPAELRYGLTRRCVKVLQKYNVPYIVFTKSVIIERDLELHRQYRDNCFIIWSITTCNEKIRRVVEPGTPPASKMFQVMKKFTDAGVCCGVYVDPIIPLVTDSDEDLEAVVRSCKEAGLRYVFGALMRLRTDIWERMKLVLRLLEIPDGIEKYKQIYNFEEPLDANYVAANRRYAEKIIGSLEDRIKSYGMECGFPDYMGPRRIDRSHLGQTTLHSYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA57</accession>
    <name>K0IA57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58186">
        <property type="protein sequence ID" value="AFU58186"/>
        <property type="gene ID" value="Ngar_c12460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12460"/>
    <dbReference type="HOGENOM" id="CLU_716925_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1244-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="385" mass="43828" checksum="B6A5F79E0DE5B8E9" modified="2012-11-28" version="1">MASSREKKRKSIVFYAIIGVLFFGVLPVLTAFYINLPKALTGQLVNYSFENEFISGDITINNHFRSRPAAPNDELEYKVLYKNKADFPLSIDSQLEVIVGGDVFKQFSFANPLIVEPFSSKEHYRIFFSDREGLNQIRLISIISNATSGDFVTREESTWNIPVISLSDQLQTELNGYTLIGLIMSIGVGLVTVVALVTNMSFSKDQVIELRRQNKNLEEQVSLTKTQMNAQLRPWLGREDLVEEGIFLPNREQITAERVNEMIRLGQPLDGIINTGILFIKNYGQLPAENVRFQSVIQLRADEPTAEVFNNAQFGPPAVVMPGETVPLRFDIPVIARLRTLQQEPPNRLFIMYHIEYSYPNGSGLYEVIIEFVPNRFVVRHYRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAV7</accession>
    <name>K0IAV7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">apgM</name>
        <name evidence="6" type="ordered locus">Ngar_c15320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15320"/>
    <dbReference type="EnsemblBacteria" id="AFU58466">
        <property type="protein sequence ID" value="AFU58466"/>
        <property type="gene ID" value="Ngar_c15320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1494"/>
    <dbReference type="HOGENOM" id="CLU_034906_2_0_2"/>
    <dbReference type="OMA" id="YVHLKGP"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="14"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="432" mass="46660" checksum="B86576A159F373DB" modified="2012-11-28" version="1">MTKSSSVAMKGIRLVYVLLDGIGDLPHPLLNDLTPLEAAYTPNLDALARNGAMGKVISVGKGIAPQSDIAVFNMLGYSFKDGSYVGRGVIESIGCNIDFRDGDLALRGNFATIDDKLKIVDRRAGRVISSEEAKAVCKTLRDNIRFSDKDASIALEPTIAHRVVIRLRHAKMKLSDKITNTDPAYDKIDGMGIAKDTTGEMFVQKSAAEEDSDQARTAAKMLNEFTTQVVQLLRDHPVNRARIAAGKKPMNCIIARDSGNRYPHVDPIDKKHGISVGCIVDMPVEIGISKVLGMKMFQAGDVNDYEEKAKVAAKSLKSVNAVYVHIKGPDEFGHDGDARGKKKNIEDIDKRFFGTLMNELKGSSTAIVVSGDHSTPCVKKGHSDDPVPLLVSGSMVKQDGSARFTENYAKRGNLGLLMGADVLSTAIKMVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB33</accession>
    <name>K0IB33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16130"/>
    <dbReference type="EnsemblBacteria" id="AFU58546">
        <property type="protein sequence ID" value="AFU58546"/>
        <property type="gene ID" value="Ngar_c16130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16130"/>
    <dbReference type="HOGENOM" id="CLU_014340_1_4_2"/>
    <dbReference type="OMA" id="ICYGAEI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1611-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="19935" checksum="20988BC5A183DF04" modified="2012-11-28" version="1">MPVLVVDNLSPFTPDILDCLGRLGITNVYRKFSEVSEPELAQCDKVILSGRRKNSKEINMVNSRIIRHCHDGGKPLLGICYGAEIIALTLGGSLRKMPAHVQGTTKVSVSDQNPLTGDKKLISVYESHGYCVAKLPANFKSLASSQYCEHEIFASGKIFGTQFHPEKSGSDGLALLQNFVAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC05</accession>
    <name>K0IC05_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="4" type="ordered locus">Ngar_c19290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19290"/>
    <dbReference type="EnsemblBacteria" id="AFU58861">
        <property type="protein sequence ID" value="AFU58861"/>
        <property type="gene ID" value="Ngar_c19290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1908"/>
    <dbReference type="HOGENOM" id="CLU_034626_0_0_2"/>
    <dbReference type="OMA" id="KYMIVAQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="3">
        <location>
            <begin position="152"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="410" mass="44855" checksum="D6779459B6145B16" modified="2012-11-28" version="1">MVEKADIIGAIFGQTEGLLGPEMNLNELQKVSKVGRIEVNVDTKGNMAKGDALIPMSTDISTAALIAAAIESIDKVGPFQAKFNLVGIDDIRAIKKKVIVDRAKKIVQDWATRTISEGEEMLKDVYDASKPGKLTSFGKAQLACGTGVFDSDWIILVEGRADVINLLRAGFDNAIAIEGARIDETVTKLTEGKRVVAFLDGDRAGDLILKELHGLVKIDKVLRAPPGREVEECTPIEIAEILKDALVPEAPQQQQPQPAHAHHDRDRDRRHSRRDREREPRDEYRAPPPSQQHEPVAVPAQPSKEVIAEDSPEILTAIRDVYPQINETLEAVVLDGSMNKLLKVPVSEVIKRLDSAEGGKLLVIDGIVTQRLVDAADKAGIEYVVGHRTTDLKKPGDIRIRTFGDIGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICF2</accession>
    <name>K0ICF2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57245">
        <property type="protein sequence ID" value="AFU57245"/>
        <property type="gene ID" value="Ngar_c02970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02970"/>
    <dbReference type="HOGENOM" id="CLU_1044336_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-297-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="30453" checksum="04525EF46E255BE7" modified="2012-11-28" version="1">MAELDPSTFSGGDETNPFLKARGFDIVLMSDALDTEELKEALQEQEHDFAPVLKRYLEDKFSIKVNKIGRANLQLPSRTVIHGKGSKNYSKDPRTKIYWFGLDEDIFNEFITNPKFFLCILLDNPATTYVLPKNIVLKIFKGKPTKKRPGRDTERWLFAIRIKEDKCILKLNNVDEVNDITPFLNKWDQIDDFKNSGIQSEAQSPSSDTYLLLRKEKPIDYNDPEFDAGPDNPNRSRLKIGAYVVVAGRKGEQTVLYGYGQIKSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICP3</accession>
    <name>K0ICP3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">thiL</name>
        <name evidence="4" type="ordered locus">Ngar_c04590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04590"/>
    <dbReference type="EnsemblBacteria" id="AFU57405">
        <property type="protein sequence ID" value="AFU57405"/>
        <property type="gene ID" value="Ngar_c04590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04590"/>
    <dbReference type="HOGENOM" id="CLU_046964_2_1_2"/>
    <dbReference type="OMA" id="DFGWRNV"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="143"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="312" mass="33273" checksum="5D4C2647070B4EDD" modified="2012-11-28" version="1">MTKLDEKEIIRIFADKLGIADLDDVVLLGKGVVFKTDMLVASTDVPDSMEAWQIARKSIVSCVSDLAAKGVRPHAAMISLGLPENRTRPYVEGLAEGFAIASKEFGVKIVGGDTNKANELVIDCSMVGFASSGKIPTRKGAGPGDFVVVSGMFGLPPAGLAILMQNTVATGAFKKQAAESVLVPKPRQRFGLALAKYFSSSIDSSDGLAISLYELASQSRVNIAIENVPAAEGVEKFAQENGLDAHELVFHGGEEYEIVATIPRSKLKQAMAAARKAGTALHVIGRVQRGAGDVFVGKRLLENRGYVHFRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICY4</accession>
    <name>K0ICY4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59226">
        <property type="protein sequence ID" value="AFU59226"/>
        <property type="gene ID" value="Ngar_c22990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22990"/>
    <dbReference type="HOGENOM" id="CLU_502164_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2297-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="545" mass="60690" checksum="F7F81D591FC2C463" modified="2012-11-28" version="1">MYPYKLDRNPYPSSPTPTLIDAQILGGRRHKDAKAALLSCISDLHSKVSAGTATDKDFRLVTVIQDVGSGKTHLALHTKGLKEVSDSAVVSYVDLSQISPRNMHSLYSAMLAGFTDEYATRLRQAVVDYLREKAERNIGSAKKIFNYGFMDSLTGKSLADKAAQLLRNELVPNYTAITDTLGKEFSPVEIAILKLVIEGKFRADEQNVATLEDIIASLAALASLNLKFLHRLTLFQIDEFDADRESVEFVKAVINAHLPATALMLIFTPSSYDDIRRSNVSVFDRLEKANYKVDIAGSNTLEEIMDIVLEYIRHYDATKSFAEDQERDLAAKVKVIYDEFPDFRNVRSMLNIMYHATENAAKRDIATIDEQAIDDTIKNVYPGLRIRGSVMDVPISDFIKIRRNCNDISMLESGVRNAVKDLVNYAHEVGVVARPHSTDAKGNGIDVMYSDPYGTKVAVAVVINKDHAKSFEQISNTLKSTGFVDKLVILTNANTTGGTNGSTLVNIDRCKMIDLIYFSNKYKNNEMQQDDSQRAILLAKSIRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDC8</accession>
    <name>K0IDC8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c24780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59401">
        <property type="protein sequence ID" value="AFU59401"/>
        <property type="gene ID" value="Ngar_c24780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24780"/>
    <dbReference type="HOGENOM" id="CLU_359698_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2476-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="353"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="787" mass="90086" checksum="B34D94A64F192BE0" modified="2012-11-28" version="1">MKFGPSIGGRENCDCCACGSGLFFSIHYHNLARYLFVTLAFAGLLSTGWFGIPLVPQYLVSNEVNIIAGIFTLFSALGTIWGVMAYREFTKSIQLVMDARDAARRLDHMIGEYEYKSYNPITKDYEAGFVPAGPIDFWDKEMQVPAWMDKGKYWHILLSLQGGSREVRLTVVKDRDLPFNTGTRNVAITARQRVDGGEAKTSRYVYVVKIPQWLVMNTDRNRFADGAAGDQLAELVADLNRKIVAASDEVAEWERQRIKYPWSGMTLGIYLNKSLPLRIVYRQVIRNFPGAKRRGIEETNANLANVKDDELVASLLELASEKGIPQSRIEMLRLLVRFLKNAYTKLGLGEGASEYHNFHHSLEVSYMTLHMIPKEFQEIQFGPKDYEIALVAGLLHDYDPSQPLASHEGPKGPSVVRTMQEISKTRILDAYFTMGWEEFASYFRQFKSPLSPPEEFATTHPEFVKMNWSPLESIMVEMLIWRTDFPFFRQKLAQEMFARLQEQLASRGEDTDRIKLLAEILWLADLAVTYMGSDPVRAWDRVTNLYDELNLPKLEAVPRTDAFFSDFAENETFKQIIGMKHFPYIFRQRWSLIYQFFHEGNPSTQLNRTIATARKMYLKVNLEIGMRRGEMLQNMATNNWAEYFIGIGKDQSEVFKAKSRFTELEPQNASAFWGDTEKLLPAIADRSIDNFLMVLPEHSAPFTTMESKSSFRSMLAVISKKLTSGGAFRILTDMEKDSAGFRELVLLANQAGFQLATHNDKAYFPEGWRDPEFRHDRKVQVVVLAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDK4</accession>
    <name>K0IDK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57755">
        <property type="protein sequence ID" value="AFU57755"/>
        <property type="gene ID" value="Ngar_c08130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08130"/>
    <dbReference type="HOGENOM" id="CLU_1259131_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-811-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="219" mass="25936" checksum="F3EABBD56CE31523" modified="2012-11-28" version="1">MTDDNDSRIKLGLLNREYDNFQAYIQGRKGAKLYSATKQQADRLAERIIRNGGKINSKKQYPLILRRDLIDIQKDSKFPSVYWMKVPVYLKSLHLKIHTDYRHELTEYDLREAKVNQQAGKWYIFLGIEKETKYPRPATNVLAIDLGVRHIAVTTNTANKRPNLYGQDLRRIRGFYFNLRRKLGQKKVFYKIKRQLKHTEFLQVNHELHKISEAMVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDR2</accession>
    <name>K0IDR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56953">
        <property type="protein sequence ID" value="AFU56953"/>
        <property type="gene ID" value="Ngar_c00030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.4"/>
    <dbReference type="HOGENOM" id="CLU_512543_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="531" mass="58101" checksum="1EC37B5EF955D138" modified="2012-11-28" version="1">MENTTDADLSSFEGKYPKDLFNKNVEANGQAIGRIAKETDDTIVVFSDSGNLRFDIPKSKIEMAGGSVIVKEEALDQYVVDKDAPLPESGGLRPSAEEIIQKAGEIPERPSASVPGEQQEYRQPSAVEEKAIDIADDVTDEFKGVGRELEQAAKTAKGKMEEIGATAASDMEEAARQAASSTSSLARSGARAAKEKIVAAQSNTEAGLSSDNILKIEKESRQPSTEVNLGSYEGKYPKDLFNRTVLLNNQQPVGRVVRETDDIIVVFSDTDSSIRFDIPKSEVTLAGGSIVANEDLLFRYRKRRDDPIPPGRALRPSGKEIRAAAAEQVVVEAEQKKRTTPDAVMQQGDYLAAMPPPETTVVSRPEGYVGTESELSKKVKGALAELKEIIVAGTKVAKKKAKQAQLQAAEKQAEMDAAAISRMGGLSARFADSFEEILSEIRTRTYADQEQIYTGFLKLMDTQRELVVARRDLARRLKDSVNVPVVDNNPQLDVPPELPEDVSKSRTLTEGRNTTTTKTRRTRKTIRKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDR4</accession>
    <name>K0IDR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57860">
        <property type="protein sequence ID" value="AFU57860"/>
        <property type="gene ID" value="Ngar_c09180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.878"/>
    <dbReference type="HOGENOM" id="CLU_1987739_0_0_2"/>
    <dbReference type="OMA" id="NLMELHY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-916-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="14696" checksum="9BA02DEC20A0BD13" modified="2012-11-28" version="1">MASYYYDSYTIIEFLDKNQKYKEYFTEHRGILTALNLMEVSYSLQKHFGFRSTAEHLEPFLPYVVTFDLSDIDAAMKLRLALEKNKKLNISYVDALGYHLAKKHNVLFLTGDRHFKGLDNVEFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDY8</accession>
    <name>K0IDY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59591">
        <property type="protein sequence ID" value="AFU59591"/>
        <property type="gene ID" value="Ngar_c26700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26700"/>
    <dbReference type="HOGENOM" id="CLU_3245478_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2670-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="42" mass="4934" checksum="CB3F33785F41E9AE" modified="2012-11-28" version="1">MLFASALIYFPSPAKFKIAKKSLFSSKRYAYEFPYQISKDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEJ8</accession>
    <name>K0IEJ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate synthase subunit beta</fullName>
            <ecNumber evidence="6">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">korB</name>
        <name evidence="6" type="ordered locus">Ngar_c28560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28560"/>
    <dbReference type="EnsemblBacteria" id="AFU59776">
        <property type="protein sequence ID" value="AFU59776"/>
        <property type="gene ID" value="Ngar_c28560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2828"/>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OMA" id="CSGKTSH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="5">
        <location>
            <begin position="200"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="322" mass="35521" checksum="1F7C9D9981436940" modified="2012-11-28" version="1">MALKLSDYKTDVHNDWCPGCGDFGILNAIQMALADMQVQPYRATIFSGIGCSGKTPHYIKTYGIHTLHGRVLPFAQGAKLANPDLEVIAVGGDGDGLGIGAGHFVSAGRRNVDMVYIIFNNAVYGLTKGQASPTLKLGMKTKSLPQPNVNNSVNPIALALVAGFTFLARGYSYDVRHLKDLIRKAITHKGLAFIDVLQPCPTYNDINTKEWFQGLDNIDPETHKAMPRMYKLEETGYDGVVHDPSEIMQKMAQVVEKSNEWGDKIPIGVFYQNEHVPTYQERIAARIPDYMENAPAIQQIADSDGRTITNIDRLLADLQVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEN6</accession>
    <name>K0IEN6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57243">
        <property type="protein sequence ID" value="AFU57243"/>
        <property type="gene ID" value="Ngar_c02950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02950"/>
    <dbReference type="HOGENOM" id="CLU_1202652_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-295-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="230" mass="26853" checksum="B4A608731E202ED1" modified="2012-11-28" version="1">MLDPFDTRLKSLENQVSLRIKEGVIRKRAYKQLFEWTIKYRELNLRTVSANKTNFPIDRLQNLDTMFEVWILFEFLDFLRNKGAVIDSSSFRKDKGFSIVFDGIEFRLFYEKEGGYLGWASNAFPDFTIEVNGHLKVVMDAKNWLQQKDEAVYKMLGYLDNLDCELGVLFFSNGKKLARSGIIKPTTPLKNHLNQCLINVVTPFSNLPDNIEVKQRSLESLFDQIIEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IER9</accession>
    <name>K0IER9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59851">
        <property type="protein sequence ID" value="AFU59851"/>
        <property type="gene ID" value="Ngar_c29330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29330"/>
    <dbReference type="HOGENOM" id="CLU_1575001_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2933-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="18378" checksum="A9A47DC8DCF7CD03" modified="2012-11-28" version="1">MPETVQREEILEEGDLKGKSAALLADIDSMIDQTLQIYELTSKEGEIIASIGSSISVLLSTLKLSVALSPNIFQNDFPAIKSAVLNANAEIIIMQANGNIVTKKFSDLDSSQAVSVIKEIIPKINQSAEAKKADVTEKIVLMKKVAKQFQRVKSMPSAPSNSKEEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF65</accession>
    <name>K0IF65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30900"/>
    <dbReference type="EnsemblBacteria" id="AFU60006">
        <property type="protein sequence ID" value="AFU60006"/>
        <property type="gene ID" value="Ngar_c30900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3062"/>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_2"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3090-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="29809" checksum="F65C52889DD46723" modified="2012-11-28" version="1">MKIGQVQIGKKLAPKVLGIINASPESFYKGSVKTSEQEIATAARQMQEHGASIIDVGAMSTAPYLETVIPIDEEIRRMKKAIRAVKSACDLPVSADTPRAAVAEEAVAAGADAINDVTGLKYDEKMSDVMTKAGVPAIIGAYSKAPATGRLAGTVKALKESLVIAKQAGIKDVIVDPSIGFFREEGKNPFFTKMTDVPWYARDIEVLSNLDKLAALGPVCVSVSRKSFIGHLLNVQAEDRLVPSIICEAVAVLNGASIIRTHNVRETVRALTMLQLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF87</accession>
    <name>K0IF87_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57483">
        <property type="protein sequence ID" value="AFU57483"/>
        <property type="gene ID" value="Ngar_c05400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05400"/>
    <dbReference type="HOGENOM" id="CLU_1718269_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-538-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="16686" checksum="94386FD60D322E16" modified="2012-11-28" version="1">MSLNQGCLAEISFQDYSLSALWDARDGDIILKNSQRRSYAESFDQKLLRVYNDQTVDFKEELKAEPLEVVYKEDLVVNPGLQRIAQLIVGESTTSFTHMASGTGTTGETTDDSVLAAENARVSLSTSGYRVSQGIYVKMGGFFPKSIATANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFF9</accession>
    <name>K0IFF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monovalent cation/proton antiporter-2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c06250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57568">
        <property type="protein sequence ID" value="AFU57568"/>
        <property type="gene ID" value="Ngar_c06250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06250"/>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="CAMITDS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-623-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="269" mass="27911" checksum="1C89FEF31D2AD30E" modified="2012-11-28" version="1">MARLVQRMKQPIVLGEIIAGIIIGPFAIGGLLLIDGRPIVMLDETVLIIGEISAIIILFVAGMGTTPKELMKLGAPSFTVGALGVVAPFFVGYFVFVSIGIESLHVIIVATALIATNIAISVKVLSELGRLQSREGRLILGAAVADDVLAITVLSVVLTMVRTGNINPNINGVALSLLQILGIYAATLVASVVAIPRLLNLEIWKPHGSTEVAATAACFAVSGAASFAGLSPIVGAFAAGMAVTASKAFQQIRQYAEKLDIVFAPSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFG7</accession>
    <name>K0IFG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal A1A0-type ATP synthase, subunit C</fullName>
            <ecNumber evidence="3">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atpC</name>
        <name evidence="3" type="ordered locus">Ngar_c31950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31950"/>
    <dbReference type="EnsemblBacteria" id="AFU60111">
        <property type="protein sequence ID" value="AFU60111"/>
        <property type="gene ID" value="Ngar_c31950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31950"/>
    <dbReference type="HOGENOM" id="CLU_784368_0_0_2"/>
    <dbReference type="OMA" id="RGKFWGL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="344" mass="38268" checksum="581FC256560AFFCE" modified="2012-11-28" version="1">MPNKIFGTVLAHSLRGKMLSKTELQTLAESRDIDELVTRMKNTVYLDALAKLTKPYTAEKVESALREHLVNQHAKIVNIANGSAILSAYFVKYITWNLKIILKGKAMGRTYEELLPKVNLRAEELVGRRDLVVKALVAKDFDEAVNSLAGSEFGEDARKAAQAYKEKGDVRVFDTFLDHAFYKSLDRAVVFESKLQDTNKVAGVDVDSYNVLAVLRGKFWGLSANEVNDLIVTTGKVSRDVLQRMINTEKIQEAIGELAGTAYKELIPRSAANDIDAIMQLEVAFEKESLKRIMNSFRTVFTVANLLASIKLMAFEIRNLAAIAAGVEQKIPSDKILASLVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFR0</accession>
    <name>K0IFR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60196">
        <property type="protein sequence ID" value="AFU60196"/>
        <property type="gene ID" value="Ngar_c32810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32810"/>
    <dbReference type="HOGENOM" id="CLU_1773261_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3281-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16585" checksum="8A54A01F947ACA28" modified="2012-11-28" version="1">MLDIPTNVLNEYLIPKDYVKPDVRVGNYFLEWNTSSYGIPQKEVSNLRRFIADLAPFLSTFIFEAALGIPRSIREKASSKEAHNFEEAFSPRLMIARKIRNSEYVLQMTADGAATLSRSETIAGDGKQADLALNWNLGQILFDRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFR8</accession>
    <name>K0IFR8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17270"/>
    <dbReference type="EnsemblBacteria" id="AFU58660">
        <property type="protein sequence ID" value="AFU58660"/>
        <property type="gene ID" value="Ngar_c17270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17270"/>
    <dbReference type="HOGENOM" id="CLU_108778_0_0_2"/>
    <dbReference type="OMA" id="EVFQVNC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1725-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="25021" checksum="1DB90A956BF303B2" modified="2012-11-28" version="1">MVAKIGAKAPNLQISRWVQGKPTNIDKEKGNVVLVEVFQVNCPGCFLYGIPEAIDIYKKYKDQGLTVLGMATAFEDYDKNTLENLQKLVMTGEVIGETYRALAQYGQLMDGNKIPYKIPFPVGMDMLKKESGQMMTDSKVMDFIEANIPDFRSYSEKDRHLLVERVKQYLRSKEYSAKTFEEYALRGTPSSILVDRKGILRSTFFGSNGFLEGAVEELLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG38</accession>
    <name>K0IG38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5'-phosphate oxidase FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18170"/>
    <dbReference type="EnsemblBacteria" id="AFU58750">
        <property type="protein sequence ID" value="AFU58750"/>
        <property type="gene ID" value="Ngar_c18170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18170"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1795"/>
    <dbReference type="HOGENOM" id="CLU_1393617_0_0_2"/>
    <dbReference type="OMA" id="VRRDPWK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1815-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="195" mass="22335" checksum="6F3749A8D1BC8636" modified="2012-11-28" version="1">MLHVVALCVLVGLLLRQKGLSTDRASHLSNVRSGCHCNCYADMLFNEFKHASINSRNFQILLLGRVTFSKAEREFLERNEACRIATCHDNIPHITPVSYVFEDGAFYIATDYETKKYENIKANNRVALAVDIYSSVGNKAVCIQGKAEIIEKGKEFARLYKIFHDRFEWVRRDPWKEGEAPFLKMTPISKVSWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGF0</accession>
    <name>K0IGF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase, IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09660"/>
    <dbReference type="EnsemblBacteria" id="AFU57908">
        <property type="protein sequence ID" value="AFU57908"/>
        <property type="gene ID" value="Ngar_c09660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09660"/>
    <dbReference type="HOGENOM" id="CLU_1451450_0_0_2"/>
    <dbReference type="OMA" id="YYLMATN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-964-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="186" mass="22620" checksum="3D7993FE1CF5F549" modified="2012-11-28" version="1">MVEKVRTLGIRIRYLTLDGGFFSIDTMRFLKESGLKKYILHMPSTRKVKKMRLSDGMRFKYRTNHHHHQRRELEQVSFDVVVAYDRTKDYYYLMATNMPSLYKSSTLLKLYNRRWGIETSYRMCNQFLIRTTSKKYIVRLFYYLFACLIYNAWVTYNEQNIPVIVVQMKLSLLWFVLNDNYMLEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGF4</accession>
    <name>K0IGF4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60476">
        <property type="protein sequence ID" value="AFU60476"/>
        <property type="gene ID" value="Ngar_c35630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35630"/>
    <dbReference type="HOGENOM" id="CLU_2534794_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3564-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9422" checksum="0E08DC20A23BB176" modified="2012-11-28" version="1">MPIFLDVHKVPFSEANLKELCMSPVDEFGVSHVNLFYNKDSGICFCLLEGPDMDAIEKHHAKVNIKCEWITEVSLARPFKPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM4</accession>
    <name>K0IGM4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar iron transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c20380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20380"/>
    <dbReference type="EnsemblBacteria" id="AFU58970">
        <property type="protein sequence ID" value="AFU58970"/>
        <property type="gene ID" value="Ngar_c20380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20380"/>
    <dbReference type="HOGENOM" id="CLU_038957_2_0_2"/>
    <dbReference type="OMA" id="SRIGWLR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2036-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="24675" checksum="11A4974C1E13D6C0" modified="2012-11-28" version="1">MRWSLGDFVYGATDGAVTTFAVVAGVIGASLSPSIVLILGFANLLADGFSMAVGNYLATKAQREYIEKARKREEWEIDNLVEQEKQEIRDIYAKKGFKDELLNEVVRVIISCRKVWIDTMMREELGLIEDSKRPRDAAVTTFAAFNAVGLIPLLPFVVMFVVGSSASPNDAFIYSVIFTAAAFFLVGGVKGRIVQKPLLRSGLSTLLVGGIAAAVAYVVGYLLNLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN8</accession>
    <name>K0IGN8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20580"/>
    <dbReference type="EnsemblBacteria" id="AFU58990">
        <property type="protein sequence ID" value="AFU58990"/>
        <property type="gene ID" value="Ngar_c20580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20580"/>
    <dbReference type="HOGENOM" id="CLU_082268_3_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2056-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12435" checksum="C335230BA9FE6ECF" modified="2012-11-28" version="1">MKKLDIIIPHENLVDVNRILHKHGVGGMSFYDIKGRGRAKQEPVSVGRGVMTYVPEFGYRTKIEVVVSDALAKSIIADVLKLLGTGSSAIGKIFVYDVKEAYDLGTKEEGDSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW9</accession>
    <name>K0IGW9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nuoB1</name>
        <name evidence="3" type="ordered locus">Ngar_c11520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11520"/>
    <dbReference type="EnsemblBacteria" id="AFU58093">
        <property type="protein sequence ID" value="AFU58093"/>
        <property type="gene ID" value="Ngar_c11520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1092"/>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="AGWVRKS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="20152" checksum="19FC6159A82C024F" modified="2012-11-28" version="1">MLRRKNRGGPALKKELVSPTNFNIMVSKLSDILVRALDAPLGYAINWGRVWSLWPVHLETACCSVEFGAASGPRYDVERFGIIEAFGSLRQCDLIVVQGTVTRKMAPRLRMVYDQMPEPKYVIAMGACAITGGLYIDSYNVLPGVDGIVPVDVYVPGCPPRPETLIQGTMLLQEKIKRSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH13</accession>
    <name>K0IH13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59145">
        <property type="protein sequence ID" value="AFU59145"/>
        <property type="gene ID" value="Ngar_c22150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22150"/>
    <dbReference type="HOGENOM" id="CLU_1212631_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2213-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="228" mass="24434" checksum="B27B53F7ACCAD034" modified="2012-11-28" version="1">MTQMTTLQIATFGSEGQEGIAAGIRNFPVHKLVLICYSSDKQKADEFSRKLRTVLGMPVMISVIARENVIRDTMERVGEIINIHKSEFQQVLMNVSCGDKLIGCAALSAAFINGIKAFGMDASGAPLLMPVLKLSYNEIISEAKIRILKAINGMGGTIESLEQLEQASGYSKPLLSYHVMGSRDSKGLADLGLLEVEKGDRGKISAKLTSLGKLLVTSSSISAPQVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH61</accession>
    <name>K0IH61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative thymidylate synthase ThyX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="1" type="ordered locus">Ngar_c22930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22930"/>
    <dbReference type="EnsemblBacteria" id="AFU59220">
        <property type="protein sequence ID" value="AFU59220"/>
        <property type="gene ID" value="Ngar_c22930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2269"/>
    <dbReference type="HOGENOM" id="CLU_024745_0_0_2"/>
    <dbReference type="OMA" id="MHRHRRC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="549" mass="63707" checksum="4A266E83DAFE4435" modified="2012-11-28" version="1">MSFDSRVFLDSFTEEEKAELKGHFSNADRAVFAIITPKQVDRGALMSRYSRTDKTMRRVFLDEFAKNPNRGEEFYRRVLLEYGDDSVAELGEAQVAVEGISNIAAKKIEDRRIGLSYLEKSSRYVAFDQKVGGRYYRYVREESIMASPHADRYIEACDHSFDTYSRSIQPLQSFLKEREPIERFSFFNSDLQKEVPFGQLKSDKDIKAAERIYNVTIKAKALDLLRGLLPASTMTNVGITGNGRAFEYLLTLMYGSKLKEIRSIADQLFGELNAVIPSFIRRANDRYGQALQEYVSKTENAIGRLAKGYLSGVPPEDRPELVKLLDFEDNSQVEVKVASAILYEQAQGQSLQRITNYVKSMPTEERHKVIRTYTEFRANRRHRPGRAFEMVDYTFELFTNFGMFRDLHRHRVLTMERQLLSTRHGYDLPQELIDAGLDKGFVECMDLAKQVYEAMAKTMPEEAQYVVNFAYRYPYFVKMNLREACHMIELRTAPQGHPDYRLACQKMYSEIKRVHPVLAEGIKFVDMNKYQLERFDAEKKTEKKRQQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH71</accession>
    <name>K0IH71_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusG</name>
        <name evidence="3" type="synonym">spt5</name>
        <name evidence="7" type="ordered locus">Ngar_c23090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23090"/>
    <dbReference type="EnsemblBacteria" id="AFU59235">
        <property type="protein sequence ID" value="AFU59235"/>
        <property type="gene ID" value="Ngar_c23090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23090"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2284"/>
    <dbReference type="HOGENOM" id="CLU_113589_0_0_2"/>
    <dbReference type="OMA" id="FSEIEHF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="PTHR11125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="5">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="24096" checksum="79566A8D011893EF" modified="2012-11-28" version="1">MSDRVDDAPEEEMGFEDIKFDDDNNQDSIEESEAAPEPAEQAAAQPEEEQMPTTTAESAAASPAPAPAEQAAPASDSKFFAIRTTGGQERVVAGQIQVRVNAKKIGIRSVMVLDSFKGYIIVEAPDSNVAYEALAGIRHVRGQIRGDLPFKDIEGYLVKKPMVSELNVDDTVEVIAGPFKSMKAKITRVDYERQEATVVLLDSPYQIPVTVDANYLKKIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB2</accession>
    <name>K0IHB2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ecx1</name>
        <name evidence="2" type="synonym">rrp42</name>
        <name evidence="5" type="ordered locus">Ngar_c23850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23850"/>
    <dbReference type="EnsemblBacteria" id="AFU59310">
        <property type="protein sequence ID" value="AFU59310"/>
        <property type="gene ID" value="Ngar_c23850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23850"/>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_2"/>
    <dbReference type="OMA" id="PESVFEM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="274" mass="29905" checksum="462FD360491CF88D" modified="2012-11-28" version="1">MSSSRRSTIIVEHLRRQQMWDSLARGKRLDGRDFNEQRPLEIEVDVIKKANGSARVKLGDSEVIAGIKVETGEPFEGLEEKGALIVTAEVLPTASPYIEPGPPDEEVVELARVVDRGVRESEMIDLDQLVLVPGKIVYTIFVDCSVINADGNLFDATSYAVVASLLTAKLPILEMKDDKVVDTGQTRPMPVTTIPVSITAARIGDYVVIDPTAEEEGCMDARITITTNDEGFCAIQKGHTGAFTVDQLKKAAETARIKGEEVRARLKELAKNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHK5</accession>
    <name>K0IHK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC efflux transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c25070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25070"/>
    <dbReference type="EnsemblBacteria" id="AFU59430">
        <property type="protein sequence ID" value="AFU59430"/>
        <property type="gene ID" value="Ngar_c25070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25070"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="EFIYIIG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2506-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="237" mass="25671" checksum="924536070D945223" modified="2012-11-28" version="1">MNTNNGSDDSVVLKVENIVKIFESAAGRVAALRGVNLSIRKGEFVSIVGPSGSGKSTLLNMIGALDRPTSGRVIINGVDVFSLSDGELATMRNHLIGFIFQSYNLINRTTVLKNVELPAILSGMDGSKMQQRAIKLLDVLGISNKADFKPTSLSGGQQQRVAIARALMNDPAIILADEPTGNLDTKTGNEVFDLLKMLSNKFRRTIVMVTHNPELAEATDRAIYIRDGTVEKEVAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHK8</accession>
    <name>K0IHK8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase/methane monooxygenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amoC1</name>
        <name evidence="2" type="ordered locus">Ngar_c25120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25120"/>
    <dbReference type="EnsemblBacteria" id="AFU59435">
        <property type="protein sequence ID" value="AFU59435"/>
        <property type="gene ID" value="Ngar_c25120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2491"/>
    <dbReference type="HOGENOM" id="CLU_1444620_0_0_2"/>
    <dbReference type="OMA" id="WFVEEIF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006980">
        <property type="entry name" value="NH3_CH4_mOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20833" checksum="4487A217622C9171" modified="2012-11-28" version="1">MPALIPKEVEIQRLKKIYIMVIMLGSIAASVEVDNFVDGSLHQTAIRDSAFTPAHWWLYSHFVALPLGWGFVAMYDRRVPILRGPGNSMNTGLKLTIIGYLATMFTIGVNEMWHFWFVEEIFAVPNHWMFNMGVVVAFMGALAYVVRVYARLVELGAETPAKNPYVAEMYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHM2</accession>
    <name>K0IHM2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA-directed RNA polymerase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoM</name>
        <name evidence="7" type="ordered locus">Ngar_c25270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25270"/>
    <dbReference type="EnsemblBacteria" id="AFU59450">
        <property type="protein sequence ID" value="AFU59450"/>
        <property type="gene ID" value="Ngar_c25270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25270"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2505"/>
    <dbReference type="HOGENOM" id="CLU_093932_3_2_2"/>
    <dbReference type="OMA" id="DVARYEM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10535" checksum="CDAD458073F9D277" modified="2012-11-28" version="1">MVECPKCGFKAKKGKQEKNATTKQENKKTTTGSDASLKVMEGDSVEALPTTNIECPQCGNGTAFWWMLQTRSADEATTQFYRCTKCSHTWRNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN0</accession>
    <name>K0IHN0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c03690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57317">
        <property type="protein sequence ID" value="AFU57317"/>
        <property type="gene ID" value="Ngar_c03690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03690"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.356"/>
    <dbReference type="HOGENOM" id="CLU_1088267_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-369-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="27297" checksum="6C4259E9A9C686F9" modified="2012-11-28" version="1">MSAIPYALLKDSVAIKIKSLAEHAPADGEKIFFAFPRQDLSPSVVTADIFFASIYSDGSWSIRPLGVYQRPGVTAPPEAWWGGMDFVIDHGTTRCPDCLSRSWVATGYPLKQPYQFYKITSQEPTPSQTTTTSTTPSQSQNQGTTPTEAISQPTIPGVTPTPTPTPTPTPSQTTTTSTTPSQSQNQGTTPTEAISQPTIPGVTPTPTPTPTPTPSQTTTTSTTPKQWYEDVTTLIVLAVVAMISIAVVIVVRQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN5</accession>
    <name>K0IHN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58438">
        <property type="protein sequence ID" value="AFU58438"/>
        <property type="gene ID" value="Ngar_c15030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15030"/>
    <dbReference type="HOGENOM" id="CLU_3282983_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1501-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="40" mass="4459" checksum="D4E29E4CB1B3E099" modified="2012-11-28" version="1">MPAGTMAKKTLTNVAKSITGEGDTNPMREELELMRTKEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS2</accession>
    <name>K0IHS2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA topoisomerase IB</fullName>
            <ecNumber evidence="7">5.99.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">top1</name>
        <name evidence="7" type="ordered locus">Ngar_c04450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.99.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04450"/>
    <dbReference type="EnsemblBacteria" id="AFU57392">
        <property type="protein sequence ID" value="AFU57392"/>
        <property type="gene ID" value="Ngar_c04450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.427"/>
    <dbReference type="HOGENOM" id="CLU_009193_2_0_2"/>
    <dbReference type="OMA" id="RNYIDPR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="SSF56741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOPEUc" evidence="6">
        <location>
            <begin position="153"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="436"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="549" mass="63669" checksum="0EEC77192270F1D4" modified="2012-11-28" version="1">MKWQTLEHKGVAFPPEYQPRGIVVTIRGEKLALNRDQEELIYAWAKKKDTHYVQDPVFQENFMSDLRPLLPEKFRNITIKDIDFSAAYRLADEEKRMKEQEKERYKTLAKEEKKKISLAKKAERERLKATYGKAVVDGVEVDIANWLVEPPGLFMGRGQHPMRGRWKPRVRPQDVTLNLGENAPVPEGNWKEIVHDHSSTWLATWIENLTGKRKYVWLHDSAALRQENDRAKYDKAKKLAEQESRVHREVIRRMMKGGDKTATVAYLILKLAMRVGDEKDPDEADTVGASTLRVEHIKFPQAGGGRQMIEFNFLGKDSVPWQKTLEVNSDDTKALYENLKKFMQGKKPSDPIFDGINSRKVNAFLQEIMPGLTAKVFRTCIATRVVQQELSKAKVDKNSSEAQKIYAARKANLEAAIKCNHKKGVDPKNPAAKKALEKFEESIAKKKEAIAQLKADIAAKKWKTELQEQRLKERLEKIEVQLKLQQETRDYNLGTSLRNYIDPRVMKAWLNYVELDWTKVYTATLQRKFKWVEGHKDKNFRTFYPEMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT6</accession>
    <name>K0IHT6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative arsenical pump membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">arsB</name>
        <name evidence="11" type="ordered locus">Ngar_c04830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04830"/>
    <dbReference type="EnsemblBacteria" id="AFU57427">
        <property type="protein sequence ID" value="AFU57427"/>
        <property type="gene ID" value="Ngar_c04830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.461"/>
    <dbReference type="HOGENOM" id="CLU_011920_3_0_2"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="21"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="434" mass="46640" checksum="24271EB5D307111A" modified="2012-11-28" version="1">MNTLLHYMQEYIALGVFAVVYTLIIGRRRFGVPIWAAMLIGAALMIGLQVIGVEAAFMSVNLDVIAFLFGMFSIVSALDRAGVLRRVAIRMLAVAKTPDRLLMAFVVGMGLLAAFLVNDTIALLGIPLVVYVARHAGIRPVVLLIALAFGITVGSVMTPVGNPQNLLIAIESGILMPFTTFLVQLAAPTIVNLFMTYAILKVYYRKEIKLNYQLSAIELAENTDRVYSPRLAKISIAVLVATIAGFIVSEALHFLGIVEFSLSTVAMLGSAAIYAVSDQRREIMKSVDYSVLVFFGGMFVVTSALWSSGAVSLLFMNYIPTPDPADPVQSATVISAASIGISQVLSNVPFVALYNFVMTDSGFTGQHVDQWMMLAAASTIAGNLTILGAASNIIIIEAAESRGVTAFSFLEFFKVGSIVTAANLAVYYVFIVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV9</accession>
    <name>K0IHV9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59525">
        <property type="protein sequence ID" value="AFU59525"/>
        <property type="gene ID" value="Ngar_c26030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26030"/>
    <dbReference type="HOGENOM" id="CLU_2784239_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2603-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7586" checksum="5F974886B57E9BB4" modified="2012-11-28" version="1">MLVGPSFVCNQVASKTVLCLHWNLEPRTSSGTVEQYTTAAIKSHIKMEISTLAETPNRWVLTKEARPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX7</accession>
    <name>K0IHX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c05690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57512">
        <property type="protein sequence ID" value="AFU57512"/>
        <property type="gene ID" value="Ngar_c05690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05690"/>
    <dbReference type="HOGENOM" id="CLU_032903_9_3_2"/>
    <dbReference type="OMA" id="ASRNIEM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-567-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="23221" checksum="830D770D0D343AA8" modified="2012-11-28" version="1">MENPQFLTKMLKPLKRAHRRLSRRQIGSSNREKAKRMLVRLYERIHNKRKDFLHKLSTYYSSRYDLIFLERLKVANLTRNHRLARRILDASWSTFKNMLQYKANRVVEVEPAYTSVDCSRCGHPVPKSLAVRTHVCTECGAVLDRDYNASLNILKRGLESLMMTMLLLPVERREVTPVEIAMQSRKQEEEAHVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II29</accession>
    <name>K0II29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58593">
        <property type="protein sequence ID" value="AFU58593"/>
        <property type="gene ID" value="Ngar_c16600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16600"/>
    <dbReference type="HOGENOM" id="CLU_2392996_0_0_2"/>
    <dbReference type="OMA" id="SKYANVM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1658-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11324" checksum="040260364E11068A" modified="2012-11-28" version="1">MSSETMSSREIIETGLGSIGKVKIIRALAEESKLATIYVLHKKTHLKREDIKNNLDDLVRIGWVTQSKYANVMYGINRENEYVNKLIEFFNDVGYIGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB7</accession>
    <name>K0IIB7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58698">
        <property type="protein sequence ID" value="AFU58698"/>
        <property type="gene ID" value="Ngar_c17650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17650"/>
    <dbReference type="HOGENOM" id="CLU_2893373_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1763-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7125" checksum="314E6D756E2CC27E" modified="2012-11-28" version="1">MYMAETLELESFDISFSFRCPKCDYLNEEVTAKDLSSGNAECGMCETIFKVEGLDAVKITATLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL8</accession>
    <name>K0IIL8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57932">
        <property type="protein sequence ID" value="AFU57932"/>
        <property type="gene ID" value="Ngar_c09900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09900"/>
    <dbReference type="HOGENOM" id="CLU_1902003_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-988-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="15257" checksum="F80BEF53BEB2F8FE" modified="2012-11-28" version="1">MKRHGIIEGVEDNIQIGALNLMNIATIFPEATETMSGEATDAEVAAAHLLQKWKNVIYKTKQQGDNRRRKKYKGILIVADDISIFATTKNFGILLLFEQKIRQNAREKNWLEVICCYNKKIISTWQLATINYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM6</accession>
    <name>K0IIM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57947">
        <property type="protein sequence ID" value="AFU57947"/>
        <property type="gene ID" value="Ngar_c10050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10050"/>
    <dbReference type="HOGENOM" id="CLU_2766233_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1003-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="8122" checksum="E532738C08017676" modified="2012-11-28" version="1">MNLLMPKIKQQIIEDMTKAGLRLDDKTAYYSLAQIRDYLHLIFGEDVAELLADVLRNTLEKTRQFEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ06</accession>
    <name>K0IJ06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c21530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21530"/>
    <dbReference type="EnsemblBacteria" id="AFU59083">
        <property type="protein sequence ID" value="AFU59083"/>
        <property type="gene ID" value="Ngar_c21530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21530"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2133"/>
    <dbReference type="HOGENOM" id="CLU_481147_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2151-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="357"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="596" mass="67258" checksum="A4855CF0E42FFC8B" modified="2012-11-28" version="1">MSDDMNVTTTTRTTMTTSDTKRILLKYTIIPSILLSIVAIFALDLNAWKTSDVHHFYFEMFAVVLAAIFAFYCLLRAYKLDDRFYLFFGLGFLASTSFDLFHAIVAFSSAGNHQFLQHFIPQTWFAGRTFISAMMVIAIVKYSYNNSLRPPSSPNTSRTASPHHNDHNNKRQVLPLPPFEEKKESNAYANSDSAFSSHSFPSPSLRSIVFAILLLVFTSSIVFILSLFTILPFVTISNDLFHRPYEIPAIVLFSIALLFFYKKRAYRANDVFYKGLILSLIVDIFSQIIMSYSAASFDTAHNIAHILKVIAYSINVLSLASSNIQYNVKLKEREATIRQQYELLQAHEKIQREFINIAAHELRTPIQPILMNSEALMRKLPENERVSIIARNAARLQQLTSDILDVARIESQTLKLNLGRFSLKQVTLQLVNDYKEHIVDKDKVKLHCQFESDQDDGSSSDGNEIYVEGDKARITQVLSNLLTNAISFTKEGAILVTVEKKKDEKEQDAVLVSVKDTGTGIDTEILPRLFTKFASKSLSGTGLGLFISKSIVEAHGGRIWAENNSNGKGATFSFSLPAHQTHIQTPRFNTYCEMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ11</accession>
    <name>K0IJ11_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59990">
        <property type="protein sequence ID" value="AFU59990"/>
        <property type="gene ID" value="Ngar_c30740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30740"/>
    <dbReference type="HOGENOM" id="CLU_145173_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3074-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="13731" checksum="850BB3B28F5B3205" modified="2012-11-28" version="1">MSDMNNSGKKGATHENLLGILDNVIHQLDFTKKMVIIMILSFITIIPISAIIIGVLTRGEAGVALPIIAAAVFLVWLGVGIRQLIVFSKWTQKYHLYKELQKRLDERLNFERDEGAREKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ29</accession>
    <name>K0IJ29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58152">
        <property type="protein sequence ID" value="AFU58152"/>
        <property type="gene ID" value="Ngar_c12120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12120"/>
    <dbReference type="HOGENOM" id="CLU_2010003_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1210-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14805" checksum="63B31A75F2694C80" modified="2012-11-28" version="1">MNMTSRPTTANASALKQDYQDFLRKASTLFPKVDQKLLLNILQLQTTYSDWEGSVMLKVVYPAGTDMDKKKEWIFQKFQRMASIEEDKTLRFKAIHIHIEDLDRLLSEDPNIEFITGSATLAPTEAYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD0</accession>
    <name>K0IJD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59228">
        <property type="protein sequence ID" value="AFU59228"/>
        <property type="gene ID" value="Ngar_c23010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23010"/>
    <dbReference type="HOGENOM" id="CLU_148455_0_0_2"/>
    <dbReference type="OMA" id="VFMIQLP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2299-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16755" checksum="EE77EB041818A1D9" modified="2012-11-28" version="1">MPKRNFSTLEEFKANLHREGATLVEFSGSKVPCILLNQKEYEEMLQKVYGKKVRADTLLDIFYDGQDVFVDVQIKFLDTDFEENYLLYANNMIEFFEALAESGLISLAPDSSTYTNSQNVFMIQLPKKDAAERALEIIRTNAKKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE2</accession>
    <name>K0IJE2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor IIB, cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb8</name>
        <name evidence="6" type="ordered locus">Ngar_c23270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23270"/>
    <dbReference type="EnsemblBacteria" id="AFU59253">
        <property type="protein sequence ID" value="AFU59253"/>
        <property type="gene ID" value="Ngar_c23270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23270"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="GETICGT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="200"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="31666" checksum="9F7AB50B855E016C" modified="2012-11-28" version="1">MIFDMVSSEFVCSSCGCVADDRILHADSTAGTTNPSEYSDRTRTGMPESLVIHHKGLSTLIGLDDTDARGKMLEPAQKMKMQRLRTWNNRSQLNDSISRNLEKALKFLNNFGDKLYLSQAVMESAAYIYRKAALKKLAKGRSTLGLVGASLYAACRETATPKTVADVAAVCNLSSKDVMAHYKLILRELSLQMPVLHGPDYVTLIANRLDLSERTKREALRIYAMVQQNRISLGKNPRALAGAVIYLASQNCNEFLRQVEICQVADISTVSLRKRCKEIKATLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH4</accession>
    <name>K0IJH4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-sulfoquinovose synthase</fullName>
            <ecNumber evidence="3">3.13.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.13.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14870"/>
    <dbReference type="EnsemblBacteria" id="AFU58422">
        <property type="protein sequence ID" value="AFU58422"/>
        <property type="gene ID" value="Ngar_c14870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1451"/>
    <dbReference type="HOGENOM" id="CLU_040971_1_0_2"/>
    <dbReference type="OMA" id="IHFAEQR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1485-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046507">
        <property type="term" value="F:UDPsulfoquinovose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="429" mass="49080" checksum="D78B0B34E225D8C3" modified="2012-11-28" version="1">MNVLILGIDGYIGWSLAMHLAKRGHNVSGIDDFERRKNVESVGSTSAIPILDMEERISSFKQIHEKDISFYEGNLLDYDFLQQVVRETKPDSIVHLAEQPSAPFSMIDREHAIYTQHNNIEGTLNVLYAMKEYVPDCHLVKLGTMGEYGTPNVDIPEGFFEIEFRGRKDTLPFPRQPGSLYHLSKVHDSGNVHFACRMWRLRSTDIMQGVVYGTRTAEMVDDSLMTRFDFDEWFGTVINRYCAEAVIGHPLTPYGSGGQKRGFIDLIDSVQCIRIAVENPPSRGEYRVFNQLDEIYSVSELAQYVVQVGKKLRLDVKIQPISNPRIEKEDHYYKVDREHLRNLGFRPTRRITETVEIMLTDLIKYRDRIMERSEVILPRTTWARGTGERMAEPRIWTKATALPQHSHTAAADASSYPHPTSSFATSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ6</accession>
    <name>K0IJJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58452">
        <property type="protein sequence ID" value="AFU58452"/>
        <property type="gene ID" value="Ngar_c15180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15180"/>
    <dbReference type="HOGENOM" id="CLU_1656805_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1516-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="18085" checksum="9E8FDE5F9048CFB2" modified="2012-11-28" version="1">MGRKKRTSRIITIGGIAVIGALVAFMVALQVEAARNNEFRRSIDQIAFDTIALTQEYQKVEEKWMENPQDNNSTITSTFEQYKLRYQQLIDRAEGLDTPDKYKTAKSHLIKAIELEMQSNQHFYNYLISGDDSEREKAGELASQSLVSSAEYDAAIRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK72</accession>
    <name>K0IK72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FO synthase subunit 2</fullName>
            <ecNumber evidence="8">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cofH3</name>
        <name evidence="8" type="ordered locus">Ngar_c27070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27070"/>
    <dbReference type="EnsemblBacteria" id="AFU59628">
        <property type="protein sequence ID" value="AFU59628"/>
        <property type="gene ID" value="Ngar_c27070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2684"/>
    <dbReference type="HOGENOM" id="CLU_040406_0_0_2"/>
    <dbReference type="OMA" id="HIKAYWA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="56"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="369" mass="40603" checksum="AE4B408CC81F4D84" modified="2012-11-28" version="1">MQKSDTVAGGTPALEKALAGEELSYSDGVQLMKEENLFLLGAAADKARQKLCGDVVTFVASYYLNYTNVCAASCPLCAFYRKGNENDAYTLSTEQIVARSKIAVGQLGATELHIVGGFHPKLGLDYYEKMMKAIKAEFPKVTIKAFTPAEIFFIARLTKNSVKEVLSRLKAAGLDSLPGGGAEIFHKDTRKQIVIGKCSGEEWLDTARQAHELGLRSNCTMLFGHVEKPEHIIDHVIRIRDLHKKTKGFTTFIPLKFSLENTELEQKGLVTAESPSTYDLRVVAVSRLLLANVLNNISVYWVALGKKVAQVALSYGGNDMVGTAFSEEIFKAAGKETGTSTQELASLIKEIKRIPAQRDTFFNIIRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKA4</accession>
    <name>K0IKA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58762">
        <property type="protein sequence ID" value="AFU58762"/>
        <property type="gene ID" value="Ngar_c18290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18290"/>
    <dbReference type="HOGENOM" id="CLU_3057248_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1827-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5832" checksum="60A375AD1FAE4204" modified="2012-11-28" version="1">MSVSVDDGTVSIEHEEFLVDVQEDSTVHIEARDIVVDIEDSSVSVETPEKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKA5</accession>
    <name>K0IKA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18340"/>
    <dbReference type="EnsemblBacteria" id="AFU58767">
        <property type="protein sequence ID" value="AFU58767"/>
        <property type="gene ID" value="Ngar_c18340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18340"/>
    <dbReference type="HOGENOM" id="CLU_046006_10_7_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1832-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12681">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="13340" checksum="13CAF1B052866015" modified="2012-11-28" version="1">MEKSIRFYKDTLGIPIKTKSNDWTEFFNKDTVLALHPAKKKSKMKTGSGMLVGFEVSDLDSTVQKLKEKKVKFFKKPKEEPFGKHAIIQDPDGHLVSIAEIKEKSAEGFDLLGLIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC5</accession>
    <name>K0IKC5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS200 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59678">
        <property type="protein sequence ID" value="AFU59678"/>
        <property type="gene ID" value="Ngar_c27570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27570"/>
    <dbReference type="HOGENOM" id="CLU_101320_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2757-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5827" checksum="1BFAB021BA17314B" modified="2012-11-28" version="1">MHIKKILREEFPELKSRLPTLWTRSYFVSTHGHVSADVIKKYIEEQKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKD4</accession>
    <name>K0IKD4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58847">
        <property type="protein sequence ID" value="AFU58847"/>
        <property type="gene ID" value="Ngar_c19150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19150"/>
    <dbReference type="HOGENOM" id="CLU_1237949_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1913-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24875" checksum="A2B6EE6487E4DBA5" modified="2012-11-28" version="1">MCYGLGYTWQYIGETLRQRAITFANSNNDFARGLGVGLGFLYSYSKNELDHDSYKHIFKMDPNFRRGLGIGMGRAYKYLSEDTQLQALRISEEDVEFAIGFGEGMGRVYPHLENSQKKLVMSYINDGDSGFSRGLGIGFGSAFSYFEDKVKKGILSHIRHNGQLSLGLGSGLAAHISYLSELEAFKIFELARSNSLLATGLEEGCGTMFPYLSQVTKDCYLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG4</accession>
    <name>K0IKG4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58912">
        <property type="protein sequence ID" value="AFU58912"/>
        <property type="gene ID" value="Ngar_c19800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19800"/>
    <dbReference type="HOGENOM" id="CLU_2662485_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1978-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8505" checksum="3BC2861856AB08D2" modified="2012-11-28" version="1">MVAGQTPNMELFGKKVECKACGAKFKSEEELMEHGKMHMGETHDHSDHEHFACKACGVTFHSEVELKEHGQKHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH1</accession>
    <name>K0IKH1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19950"/>
    <dbReference type="EnsemblBacteria" id="AFU58927">
        <property type="protein sequence ID" value="AFU58927"/>
        <property type="gene ID" value="Ngar_c19950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1975"/>
    <dbReference type="HOGENOM" id="CLU_241434_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1993-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IG" evidence="1">
        <location>
            <begin position="139"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="1">
        <location>
            <begin position="243"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="1">
        <location>
            <begin position="738"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="1">
        <location>
            <begin position="908"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1682" mass="173774" checksum="1F4ED1BECEDCF910" modified="2012-11-28" version="1">MLVAVAAIGTTSFIFMAQDNYNTAVKKTTELVGNKGKEQITAVQLEEAKLQIANDGPATSRIIGLVSADDSTGNLSLKPLNLALPSAQKLDYTIPDSTTGGGLGSGKMGLLTSLGNIFWVDSEPLQNKPLPDFAIAVAPDSLIVEQGKTGTASITVSPLNDFSDAVFLSASGLPHGTSYLIKPSSGNLPYTSTLTVQVGSATPTGVYTITITGDDKNGGVHSATLTLQVNAASNQDFTLSVSSKTVTLQRGSSAATNSVTVSPVNGYDKTVTLETSGFPAGVTYSYNPLGAKPLFTSTLTMGSAANTPAGTYVITVKGSDDTGKVHSDTFTLQITAQPDFDLSVNPSSLNLQSGGSGSSLVSVTSLNGYPGQVSLSLSGLPSGATATFSKPSGNPSFTSVLDINAGTANPGTYNLIVTGTGSIDGKTKSAQLTLAIQETSFDFSLVLDSSNVDVQQGGSGSNTVTISPINGYNKIVSLSASGIPSGVSASFSPQSGVPAFTSTMSISASTSAAPGSYPVTVQAQGEDGKTHSTTFTLKVQAKYQLTISVQTAGPSVAPTTFISDTFGTGLDGWSYWGDSGYSLTRDTGTGSPAPSAKISGDAFATVHGMQKVVDLSSWSKAGTLTLSFNYRAASDYAGSTVTNAFVRIYNADTDQILYEETLVAGGTQDTGWKSYSKDITCSVLSSSSGSNINNKIRIVLFLGDGWSANWNQKNWYDNIKLESSASAATCGGTTSPAPGTYSYLEDESVQVTALPNAGWKLSYWTLDGVSIGSQNPASVTMNKDHALAAVFAQGQSGSDFVVSANPSSLSIAKGSSGSSTVTVNSINGYSSGVSLSLSGLPVGASYSFLPWSSNAPFTSTLTINAGTANAGTYTLSVTGTGVVDGKIRTTTITLTIAPQFDFSLSLNPSSGTVQQGGTSQTTVTTTLLSGTSSTVSLSASGGPLGMTFTFGPASGNPTFASTLTISIPSNAATGIYQITVAGSGGGVSRTATYQLTISSQTTQQPFNYAMSISPSSLSIAKGSSAQTTVSVDLLAGSSAQAVVLSSTGQPSGVAVSFNPSTGNPTFKSTMSISVSSAANAGTYTLTITGTAGALAKSTTLTLTIVNTADFTLSATPGTLTVQQGSTGSTTIKIDALNGYSNIVSLSATGLPSGVTYAFIPSSGKPTFSSTLTLSVSQSAATGTFTVTINGAGADGKTRTTTLTLTIPKQTTYQLTVGVKDQFNAPVKGITVTIDSSSYTTDTSGQVTVQVSQGTHTIAVPSSYLQSSGTRYLFEKWSDGGGVTANPRTVTVNSAVTFTAMEKKQHYLTMQVSPSSSAGTVSPSSDWYDSGKQVTISASASSGYKFDTWSGSGSGSYSGTGNPVTITINAPITETASFQKVYTVSVKTLATYGSLSTSPLSGLKVKIGTATVQTDSNGVASFALPAGTYDISLVDTSVTKSITSVDVRGFVFKWWDNLSTSNPRTINVNGPSTLIAYYPITWQQYTLNPNTYTAEVADPSKTDSLGNPVLRSVSLPYAKSASNWLLGWEWSMDVRTDNKGAHYGAHDYAAWGYTKAFTTKWNSKLTPATHSYAIDKLAISYSGYLNVKGITSDSDQGLYFRYRDTYNNKGDTSPSVDWTNTKSYNGVVGAARVFTPKQVIVGDLLVSTYQWTRGSNFDLRFGNGYGWTTNNMVATLYFTSTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI2</accession>
    <name>K0IKI2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58952">
        <property type="protein sequence ID" value="AFU58952"/>
        <property type="gene ID" value="Ngar_c20200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20200"/>
    <dbReference type="HOGENOM" id="CLU_117038_0_0_2"/>
    <dbReference type="OMA" id="AYEPLEI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2018-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="21010" checksum="209F90DE866CC4F8" modified="2012-11-28" version="1">MKAGPTRGGEFGIASKGNTWARRFMAAAIIQGAIVVGLTVFLVLGQISILNPEVSRVIASGGAGTWFTFGYLSYILVGVIGVAVSSAFYHYLAGNFKRSANALAWVHLILMNVGTSATAGMMMYAGYQGGAAMLPTAIGGRGFDAQQAHSIMAPFVEPIAGSILAILVGVIAGGAGFLIAYRRAQRFAETSPTSRRDETEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ9</accession>
    <name>K0IKQ9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-aminoadipate/[LysW]-glutamate kinase</fullName>
            <ecNumber evidence="2">2.7.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argB</name>
        <name evidence="2" type="synonym">lysZ</name>
        <name evidence="4" type="ordered locus">Ngar_c29950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP</text>
            <dbReference type="Rhea" id="RHEA:41944"/>
            <dbReference type="Rhea" id="RHEA-COMP:9694"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78503"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP</text>
            <dbReference type="Rhea" id="RHEA:52632"/>
            <dbReference type="Rhea" id="RHEA-COMP:13311"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136714"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetylglutamate kinase family. LysZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.17" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29950"/>
    <dbReference type="EnsemblBacteria" id="AFU59913">
        <property type="protein sequence ID" value="AFU59913"/>
        <property type="gene ID" value="Ngar_c29950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29950"/>
    <dbReference type="HOGENOM" id="CLU_053680_2_0_2"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00036"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043744">
        <property type="term" value="F:N2-acetyl-L-aminoadipate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02082">
        <property type="entry name" value="LysZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037529">
        <property type="entry name" value="LysZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="267" mass="28228" checksum="6CF1AAF53472FA34" modified="2012-11-28" version="1">MIVIKIGGSVVDGLHPSTLADIKAITEKDKLVFVHGGGKEVTATATKLGKEQKFIVSPGGVRSRYTDKETADIYTMVMSGKINKAITGMLLRQGIKAVGIAGIDGGILKAERKKKLLIINEKGRKMMIDGGYTGKINAVDPALVHNLVDNGFVPVVSPIALSEEYDFLNVDGDRAAAYVAGGVKADKVIFITNVNGLILNEKLVTAMTLEQAKAALPKIGFGMEKKVLACTEALEMGVKEAIIASGQVENPISSAIAHNNCTVITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT3</accession>
    <name>K0IKT3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative arsenite-activated ATPase ArsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arsA</name>
        <name evidence="4" type="ordered locus">Ngar_c30520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30520"/>
    <dbReference type="EnsemblBacteria" id="AFU59968">
        <property type="protein sequence ID" value="AFU59968"/>
        <property type="gene ID" value="Ngar_c30520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30520"/>
    <dbReference type="HOGENOM" id="CLU_040761_1_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="3">
        <location>
            <begin position="336"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="403" mass="44413" checksum="B60DA14E07EAD63B" modified="2012-11-28" version="1">MACTLLFPSLRLIIYTGKGGTGKTVTSCATAINMAERGYRTIVISADPAHTLSDALMMQDISGSYDQKQVLPNLAALQIDPVTEMSKQYDPILSYMASIFSAKGIDETLAYEIAMLPGMTQLFSLLKIEEIERTKSFDAVVLDMPASGEALRYLYFPKLVGSIGRKLTGLAGLFSGFAKVFQPVAKIPAPSRDVIKSEMDFLDRLDELAKIIRDNDTASIRLVANPDTFSIENAKRALMSASLYGINVDMAVVNKIMAGSSDEYYAKWASYQRSKVEDAKANFYPLPVKEVQLYGTELRGVEMLRKHGEVLFGSDDPAKIFYRGKPYLFVNEGAAINMTVQVPFTEKDDFSIERYGDQLTITVRTPVGQVANIVPLPVATAGMKLAKAKLMNHELNVLFEKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA1</accession>
    <name>K0ILA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative digeranylgeranylglyceryl phosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c24630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24630"/>
    <dbReference type="EnsemblBacteria" id="AFU59387">
        <property type="protein sequence ID" value="AFU59387"/>
        <property type="gene ID" value="Ngar_c24630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24630"/>
    <dbReference type="HOGENOM" id="CLU_846262_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2461-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="328" mass="35354" checksum="C98E2972C3E07A89" modified="2012-11-28" version="1">MTAIIEGGQQQPQENINSQVKASFVRSQLILFNSRRKFGLLYSLATLAGIFCVPGVIGAIGSETEILEAIRGVLPLPFISLLVAVGMYILNDLVDADLDRTNAKSRPIPSGKVSRRQVWTFIVLTNGTGVVLAASTSNLTSIMLVAPMLLIGILYSAPKVALMKRFVIKNLTIAIFYMLCVLLGITSSYGTELAFSEPIVPIHAMAIFGIMIFVGSIVNDLGDVKGDRAAGRRTIPIVLGGKSTLTTLIILLACMPAISWTLYALAADGMSMTTAIATSVVGLLAVARMTKISRVLQDAELMRKQHKKWFPLHMVLQTSFVIGGLLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG3</accession>
    <name>K0ILG3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60398">
        <property type="protein sequence ID" value="AFU60398"/>
        <property type="gene ID" value="Ngar_c34840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34840"/>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3485-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="17519" checksum="D958B40078E1DF65" modified="2012-11-28" version="1">MDAELEGVSLNSYAAKIFSNHVQWERYERKVGLLPMTEAFLSEVLSQLTDQQIVNLAQKLEKQKFRNILAFMKNSNSVEDFVEVMRAWLTVSWMQQNLEVRSGRYHFKIQHSLGAKWSLYVKTLISELSQDILGKKADISIVGDTISFVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI0</accession>
    <name>K0ILI0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59492">
        <property type="protein sequence ID" value="AFU59492"/>
        <property type="gene ID" value="Ngar_c25700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25700"/>
    <dbReference type="HOGENOM" id="CLU_3282984_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2569-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="40" mass="4563" checksum="D5EB3250D5F615EF" modified="2012-11-28" version="1">MSQVFGQRVLTSQELIDSIICWNASSIKHVDTSKREKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT0</accession>
    <name>K0ILT0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydrolipoyl dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59657">
        <property type="protein sequence ID" value="AFU59657"/>
        <property type="gene ID" value="Ngar_c27360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27360"/>
    <dbReference type="HOGENOM" id="CLU_1943927_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2736-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14375" checksum="ADCE4CC9D6273220" modified="2012-11-28" version="1">MVKGNIKKHQDLNLAVEVYYTEPPIYHVGVMEGEAKEKGIKYSTAKATYNKFPREIINGNWNENDGFIKTIFEKDSGKIIGGLVSVEEADNIIHMIMVAMRAGLTTFDLGNLPFFHPSLAEGVSYASLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT7</accession>
    <name>K0ILT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putarive CRISPR-associated protein, DevR (Cas7) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c03860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03860"/>
    <dbReference type="EnsemblBacteria" id="AFU57334">
        <property type="protein sequence ID" value="AFU57334"/>
        <property type="gene ID" value="Ngar_c03860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03860"/>
    <dbReference type="HOGENOM" id="CLU_935734_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-386-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013414">
        <property type="entry name" value="Cas7/Cst2/DevR_sub_I-B/Tneap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01905">
        <property type="entry name" value="DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02585">
        <property type="entry name" value="cas_Cst2_DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="297" mass="33947" checksum="A46E54B97FCE9424" modified="2012-11-28" version="1">MGKVVQISILAKIVGNVNADEVIGNRATLKKMYSSDGEVLPFVSARAIKFAIREALRQRSYDIDPYQKKGDQLLDSGNPVKYIDNDLFGYMHAPKKEEGQKKGVIALRRQAPIAISYLKSLRNTPIKSEFAARFPRTDGDGENPVPFEIEVAEFIGRLNCLIYEYVGLKSSDEKKEWELKREERNKRIKDFLEILLTPTYVLPRRTNSLNIPEYYVSLVTLSERGPLPIYQYLDYVNDKTIMLSIDMLNLMMSRPEIRNNIKEAYLIDYHNALDKPVNGFSSPSLSDAIGRIISFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV7</accession>
    <name>K0ILV7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59712">
        <property type="protein sequence ID" value="AFU59712"/>
        <property type="gene ID" value="Ngar_c27910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27910"/>
    <dbReference type="HOGENOM" id="CLU_1458236_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2791-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="21365" checksum="1475BEFA519DA139" modified="2012-11-28" version="1">MLALMAQLLQMHGKIDDRYAHCLIPTSEKEKIILGAIKEQGNNATTENIGKLIIFRYASPALAASAMRRMEQMRKWGTIQFHKHNWRIGPNATILSKRRNSEEDPLHGLAGVSLGTVPQELAEHFCQVCDQLIVQYADAEIIMYKGRLYICHAESCYDQLYKKINMRVKKRRTLKPLESQRRRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY4</accession>
    <name>K0ILY4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59797">
        <property type="protein sequence ID" value="AFU59797"/>
        <property type="gene ID" value="Ngar_c28780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28780"/>
    <dbReference type="HOGENOM" id="CLU_2695898_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2878-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8605" checksum="BC7980451F04DD0D" modified="2012-11-28" version="1">MMAEMVKAAVKDAKVNMPAPPLRGNAKLDDAFEHRKRNLRKDIPVVCYTHKIQFSNRRDFRLHIKYQHSTEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM00</accession>
    <name>K0IM00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulatory protein arsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c05310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05310"/>
    <dbReference type="EnsemblBacteria" id="AFU57474">
        <property type="protein sequence ID" value="AFU57474"/>
        <property type="gene ID" value="Ngar_c05310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05310"/>
    <dbReference type="HOGENOM" id="CLU_117482_0_0_2"/>
    <dbReference type="OMA" id="RCYRIAR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-529-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="229" mass="26147" checksum="9BB8B20162965566" modified="2012-11-28" version="1">MAQQTQLDSDTILDILGNDTRRKILSVLSEEPMYFNQLAKEIGIGQQAIIRHLQALEDIGLIETYGKKSEFGAPERKYYRLNTSFVLTVSLSEDDFTVSKHEIKQLRHKESKKYYESLDSIPEEAGEALSLLKQNLADIEEEISTLESRLTDLYALKQVVLRKLHEIGMDGFDAEERRLLYKIVEQSPRSIADLATFMDEKESSVKGLIKEMKGKMGKDNAQLLFGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM29</accession>
    <name>K0IM29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB family carbohydrate kinase</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30210"/>
    <dbReference type="EnsemblBacteria" id="AFU59937">
        <property type="protein sequence ID" value="AFU59937"/>
        <property type="gene ID" value="Ngar_c30210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30210"/>
    <dbReference type="HOGENOM" id="CLU_805653_0_0_2"/>
    <dbReference type="OMA" id="FANCCAS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3021-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="60"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="345" mass="36980" checksum="8A56ED69A7827E0D" modified="2012-11-28" version="1">MAIIEKLRQLSIVGSIVVMPDFFVDRIIRLESKEKFFDALGKKAARGGGSVRGVPTADVKGGNAVNVAYCLAKLGVKVALFTVADEIGAAMIRQAFSQFGDKVTLRITSGKNGLTTAFEFPHEDTLVNVMMSDIGDNANFGPERLGSEADRAILKNADGVIVTNWASNQKGTELTEFAFRNSPSAFHFIDPADIDTRKQDFASSLEKLASMTDCLSINENECNSLADALGLGHLLGSNYSADEVKGAAKKIAGKVGISIDLHSKIGAAWSNGRESTFVHAIKVDAKTITGAGDSWDAADIIGYLAGLDPQERLLFANCCASLYIRDPQGEPPAMNKVFELVERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM46</accession>
    <name>K0IM46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c30760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59992">
        <property type="protein sequence ID" value="AFU59992"/>
        <property type="gene ID" value="Ngar_c30760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30760"/>
    <dbReference type="HOGENOM" id="CLU_084115_4_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3076-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="12642" checksum="509D81AB494ADE0E" modified="2012-11-28" version="1">MNVGDIGGKGPRDSVQDPAPIPGNGTVVVSIIDNAGSNSYNLNPVEVKVGETVTWVNDDSNIYTATSNDGIFNSDVLFEGQSFSYTFDEEGEYPYFCDIHPNMVGTVMVVTQDGEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM73</accession>
    <name>K0IM73_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide/opine/nickel ABC uptake transporter, putative substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06760"/>
    <dbReference type="EnsemblBacteria" id="AFU57619">
        <property type="protein sequence ID" value="AFU57619"/>
        <property type="gene ID" value="Ngar_c06760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.653"/>
    <dbReference type="HOGENOM" id="CLU_1307857_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-674-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="210" mass="23363" checksum="6302234B51DA696B" modified="2012-11-28" version="1">MRNATFHDGKPVTSADVKFTRGGDSLRSSWQSRLGRLDSIETPDEYTVVFKLKQPFSALIFMLDMGSGGPPILPKHLYEGTGIPNNPYNQKPIGSGPFKLVSWEKGNQIVLERNENYFKKGLPYLDRIIMRIMADQTALALAIENGEIDYAPVGLSFSDAERLKELENIDVVYSGREGLGVLLTLVMNLDNPISANQKVMQSNSYPSMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM94</accession>
    <name>K0IM94_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">pyrI</name>
        <name evidence="10" type="ordered locus">Ngar_c32010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32010"/>
    <dbReference type="EnsemblBacteria" id="AFU60117">
        <property type="protein sequence ID" value="AFU60117"/>
        <property type="gene ID" value="Ngar_c32010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32010"/>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_2"/>
    <dbReference type="OMA" id="CPNRNCI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="8">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="9">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="17523" checksum="259FEF09436C2B33" modified="2012-11-28" version="1">MQYMSDTSQLLVRRIKDGTVIDHIEAGKALLVLRALSITGKEGNVITVALNVPSSKHGKKDIIKVENRFLETSETNKLALIAPRATINIIRDYKLIEKRKIQLPDSIVGIFKCPNLKCITNSGEEIRSTIDVIDKEKVVLKCRYCARTLSIDELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC3</accession>
    <name>K0IMC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase, PP-loop superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08220"/>
    <dbReference type="EnsemblBacteria" id="AFU57764">
        <property type="protein sequence ID" value="AFU57764"/>
        <property type="gene ID" value="Ngar_c08220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.788"/>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-820-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="51"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="315" mass="35457" checksum="1D0031F6468955BE" modified="2012-11-28" version="1">MFCSKCQKAESVYHRAYSGEYLCKKCFMRSIEDKAAKTISKYSMIGYGDRVAVGVSGGKDSLSLLYVLKALFEQHPNNGNELVAVTIDEGIKGYRDESLRIVRDFCAQLGVESKVLSYKSLFGVDMDEAMVLRPSEKKISSCSICGTFRRRAIDIAAETVGADVVATAHNMDDQLQTFMINLLAGDVERIGWIYPEPVQYANNRMKKVKPFIEIYEYEIAFYALQREIPFQSEECPYMNESIRTDLREFFNRMEKAHPGIKHNAYNSMMKVSKTLRNIPGDQGKKCSVCGRDSTGDVCSVCKTVSVLTSSSNKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD9</accession>
    <name>K0IMD9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60182">
        <property type="protein sequence ID" value="AFU60182"/>
        <property type="gene ID" value="Ngar_c32670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32670"/>
    <dbReference type="HOGENOM" id="CLU_3094237_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3267-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5778" checksum="C75B18A23D1BD7C6" modified="2012-11-28" version="1">MENCKNISECNRIQHNFVNPNIALEGKIPAQAAALKMRGWNELLRLALSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ2</accession>
    <name>K0IMJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09970"/>
    <dbReference type="EnsemblBacteria" id="AFU57939">
        <property type="protein sequence ID" value="AFU57939"/>
        <property type="gene ID" value="Ngar_c09970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.950"/>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-995-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="507"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="732" mass="83226" checksum="EFA7525C9F791A3F" modified="2012-11-28" version="1">MKIFLGYADNGFRREEQNTYNNNPRQTEKVEVQYGIENSVRIIQNFFSNVRKTACLCLESNAPSLTLEIKEYRDILNNTVVKRGIKLRYLTEITKENLPYCKQLMNVVELRHLDGIKGNFAVSETSYMATTIMQKEKPIPKVIYSNVPEIVEQNQYFFETLWKKAMPAEQKVKEIEEGILPIETKVLDQPDEIHNRIIKSMEISNELLICTVPNGMRLFHSEFFADILQVLKRHADGKHRGIRLVTTIQKEDLEIVKIFADAGIQIRHVQNLIPVNFAVSDKMLNATIEQMPAGLPAQSLLTSTEPLYVNHFRLIFEELWRNGVDAANRIRQMEQGHIEAHIDIINNSEQALDKAWSLVASAKEEVLLLFSTTNAFRRQAATGALQVVMRALKGGAKVKVLLPEDEQVEETIKQVKRAVPQAEFRSTDKSLETKITILVVDRKHCMLFELKDDTADNSFDAVGVTAYSSSKSIVLSYAAIIQNLWRQAELYEMMRMQERAQSEFINIAAHELRTPIQPILGIADLLESQFSDETKERGEITKDELALLIRNARRLERLSSDILEIARIETGQLRLNIREFNLNDAILPLVQDAKRQTEGKEVKIEYRPSNNNIMLRADKDRIAEVIWNLLDNAIKFTEKGTISITADRNDDSSQLLTVSVKDSGSGIDPEILPKLFTKFTSKSEKGTGLGLYICKNIVEAHGGRISAKNNEGGKGATFSFVLPIKMMNEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN1</accession>
    <name>K0IMN1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ordered locus">Ngar_c35140</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35140"/>
    <dbReference type="EnsemblBacteria" id="AFU60427">
        <property type="protein sequence ID" value="AFU60427"/>
        <property type="gene ID" value="Ngar_c35140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35140"/>
    <dbReference type="HOGENOM" id="CLU_017729_1_0_2"/>
    <dbReference type="OMA" id="HNVRMRQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3515-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="20">
        <location>
            <begin position="14"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="19">
        <location>
            <begin position="357"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AFU60427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="589" mass="65238" checksum="44A9A7312B207B82" modified="2012-11-28" version="1">MLRSRLAGLYYCLTKKNSDVAKVMRDLGFLTEVGEDDPNAQFRARAYYRAADTIASLPEDVAVMYSRNGIKGLLEIPSIGKAIAAKIEEYIKTGKVHTLEKMKAEIPINIDELYGLEGVGPKTIRALYDKLQVKNLADLEKAAREGRLRTVPGFTERKEQDVLKKIEFFRTGRGRHIIGEVYPLIKQIEKSLLQVAGVKNAVAAGSVRRMKETIGDIDYLVAASDPEPVMDFFTKMPEVQEVFGRGPAKAFVRLTSGIDADLLVVPEESWGSALQYFTGSKEHSVELRKIALSKGLRLNEWGVFKGEKRVAGAAEEEVYQALGLQWMPPEMRENAGEIELARQNRIPKLVEYGSLKGDLQVHSENSDGTATIEEMARGAKAFGLDYIAITDHTKSLALAGGLDGQELLEQAQKIAELNDRLEGGFRVLASAEVNIMKDGSLDIADNVLDKLDIVGAAIHSHFNLPVEAQTERLTRAAKNPNVDILFHPTGRLINKRLGYPVDIEQVIEVAKDTGTVLEIDAHYDRLDLKDEYARMAVKKGVKLVVDSDAHHPIHYAFLMFGVAQARRGWATPADVLNTLPADRLLKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY4</accession>
    <name>K0IMY4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14940"/>
    <dbReference type="EnsemblBacteria" id="AFU58429">
        <property type="protein sequence ID" value="AFU58429"/>
        <property type="gene ID" value="Ngar_c14940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14940"/>
    <dbReference type="HOGENOM" id="CLU_1718271_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1492-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="17245" checksum="15B39A00D3ADB54D" modified="2012-11-28" version="1">MVRRIVNRTLLKEPVLDVEVANLRERGMLGIAIAKQNNATNQKTTKTFVFLYYIEAKQDGSDAKNGDPPLGNRLYRYELMDGNLKNGKLLLDIPAERSALHNGGKILIGPDSNVYLVVGDLAHRTRLQNYEKKFNPQRNKRSISPYTGWQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY7</accession>
    <name>K0IMY7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58444">
        <property type="protein sequence ID" value="AFU58444"/>
        <property type="gene ID" value="Ngar_c15090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15090"/>
    <dbReference type="HOGENOM" id="CLU_198710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1507-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6307" checksum="4B2EEB7E2833A910" modified="2012-11-28" version="1">MPSEPVVDWDSIIHKNIRSSDGQPAGNVVAIEGDTILIESQGDPVHGAIPKSLVARFNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN07</accession>
    <name>K0IN07_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16110"/>
    <dbReference type="EnsemblBacteria" id="AFU58544">
        <property type="protein sequence ID" value="AFU58544"/>
        <property type="gene ID" value="Ngar_c16110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16110"/>
    <dbReference type="HOGENOM" id="CLU_131496_6_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1609-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="13042" checksum="7E429121B4E3968B" modified="2012-11-28" version="1">METTTDIKKFQSRTADAVRVLAFFKAKQGKGKALEKILLTLVRPTRSEPGNIAYVLHRSTENPDELVFDEIFTSMHAFEEHAQQPHIKNLNARIEHLLVAPPEVKTYSEVRVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN35</accession>
    <name>K0IN35_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17510"/>
    <dbReference type="EnsemblBacteria" id="AFU58684">
        <property type="protein sequence ID" value="AFU58684"/>
        <property type="gene ID" value="Ngar_c17510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17510"/>
    <dbReference type="HOGENOM" id="CLU_029499_2_2_2"/>
    <dbReference type="OMA" id="TMCVREY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1749-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="297" mass="33778" checksum="1C83136DF048240A" modified="2012-11-28" version="1">MLQKAKSRLKNEMQPVWHRHWQGLPMRPHRGQGYVQGMLPRDPLAPHKQRTEENAVMITFYTNRTTLGYIMKAVILAGGFGKRLKPLTDQRPKPMIEVLNVPIIEWQVRWLRKFGIKDCVLCVGYMRGQIFDHIGDGSKFGAKIKYSVEEEPLGTGGALKNAQDLLSDQESFLMLNGDVLTELDPNRLNLAGSHTIALVPLRSPFGVVELDSDSKVLGFVEKPEILDRWINAGVYHFTREVFRYLPENGNIEVTALPALAKEGKLKAVKYQNVFWRSIDSHKDIEEAAKEMQAVRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN43</accession>
    <name>K0IN43_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58724">
        <property type="protein sequence ID" value="AFU58724"/>
        <property type="gene ID" value="Ngar_c17910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17910"/>
    <dbReference type="HOGENOM" id="CLU_3003263_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1789-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6664" checksum="FABA0605BF536916" modified="2012-11-28" version="1">MQGDELDKEGYWSNELDSLGINVKRKNELNDRKEMRDLVENVKQVMLQEYRNAYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN86</accession>
    <name>K0IN86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58939">
        <property type="protein sequence ID" value="AFU58939"/>
        <property type="gene ID" value="Ngar_c20070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20070"/>
    <dbReference type="HOGENOM" id="CLU_2447765_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2005-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="9824" checksum="F91977265E104042" modified="2012-11-28" version="1">MRPWRIAIGGLFLAAGLVFMFPHASGIGNVCYPASGAVHSPFPEYFEGCNLWLRTNPTYPIFIPLMVIGLSFLILELRDSRPASLEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE4</accession>
    <name>K0INE4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59229">
        <property type="protein sequence ID" value="AFU59229"/>
        <property type="gene ID" value="Ngar_c23020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23020"/>
    <dbReference type="HOGENOM" id="CLU_209485_0_0_2"/>
    <dbReference type="OMA" id="HAWEVEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2300-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6897" checksum="AE1C9D91234F225F" modified="2012-11-28" version="1">MAVERKKEEPTKDDQGVPPEIDTHYQMYGKHAWEVEYGERCPACNKRIDEFGFCACGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI8</accession>
    <name>K0INI8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">pcn</name>
        <name evidence="8" type="ordered locus">Ngar_c25260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25260"/>
    <dbReference type="EnsemblBacteria" id="AFU59449">
        <property type="protein sequence ID" value="AFU59449"/>
        <property type="gene ID" value="Ngar_c25260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2504"/>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="126"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="250" mass="27558" checksum="E6F979E954981DD6" modified="2012-11-28" version="1">MVFVARSKSPEEWKAVASAISTLVDEATFEAAAEGISFRGMDPSHIALIDIHWPNHAFEKYECDSLVKFGIRVDEFSKLIKRADKKDAIEISLGDDSMLHVKMSNGYKREYKTRLIESSASSTPLPKLNFNSKAVLTATAFDKVLSDVQVVSEYISIESKSGRINFSGRGDSGEADISLEAGNEGLEELAVKEESKATYSLDYLSKITKAVISMGGSVAAEYSSKMPLRLEFKIANVGRIHFYLAPRVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP2</accession>
    <name>K0INP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59719">
        <property type="protein sequence ID" value="AFU59719"/>
        <property type="gene ID" value="Ngar_c27980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27980"/>
    <dbReference type="HOGENOM" id="CLU_1324059_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2798-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="23899" checksum="DA69F54EFA847839" modified="2012-11-28" version="1">MNTNAEATDSEQYRDRIRIKKAPLEIEINRDSEPTVRRYLWENIGRSEGLTVEDAVNESAEKADCSPVTSRRHIMKACSLAGPFKIEEFQNKDYILLRDGYSPSLQSRLGQLDSQIMKERIAKAEEEKRQKEQELLAKAEQLKETEEQQQKLTKSFNKKCLEVELLQKLLKTKYGLTEEQIQKELGGMTKVLVNNEDKTTSQRPHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP7</accession>
    <name>K0INP7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl11p</name>
        <name evidence="4" type="synonym">rpl11</name>
        <name evidence="8" type="ordered locus">Ngar_c28240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28240"/>
    <dbReference type="EnsemblBacteria" id="AFU59744">
        <property type="protein sequence ID" value="AFU59744"/>
        <property type="gene ID" value="Ngar_c28240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28240"/>
    <dbReference type="HOGENOM" id="CLU_074237_4_0_2"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="6">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="16366" checksum="A14DB2424B02B606" modified="2012-11-28" version="1">MGDKKSISALVNGGEANAGPPLGPALGPMGVNVLQVVNTINEKTKDFPGMKVPVKVEVDSETKKFTVEVGIPPTAALVAKEAGIPKGSGTAGTNYAGDLTMASAVKIAKMKIDGSYAFDVRGAVKEVIGSCVSMGVKVEGKPAKEVYADIAAGKYDDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR5</accession>
    <name>K0INR5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Ngar_c29150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29150"/>
    <dbReference type="REBASE" id="55350">
        <property type="entry name" value="Nga92ORF29130P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59834">
        <property type="protein sequence ID" value="AFU59834"/>
        <property type="gene ID" value="Ngar_c29150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2893"/>
    <dbReference type="HOGENOM" id="CLU_005762_1_0_2"/>
    <dbReference type="OMA" id="YDMTQAV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2915-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021810">
        <property type="entry name" value="T1RH-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11867">
        <property type="entry name" value="DUF3387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="284"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="904"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU59834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117804" checksum="AB6860C95747E6BD" modified="2012-11-28" version="1">MPKAISEADVEENVLAILESMGYKIIRGDNEDCLPGGSSALRADYKDVVLVDRLTDSLRKINPSAPIDALDQAIKQVLRSESQKLIANNESFHKMLVDGIDIPVQTLEGETYKKIWLFDFEDPENNEFLAVNQFTVVENNIERRPDVILFVNGIPLLVIELKNLADENATIWTAYDQLQTYKEQLPSLFKYNEILVISDGIEARAGTLTSERERFAQWKTIDGGAPRKGLTEIEVLIRGMCNKQRFLDIVRNFIVFEKDKSVSKKLAAYHQYWAVNKALESTIKARKGNKKAGIVWHTQGSGKSLTMVFYTGKLVRELDNPTVVVLTDRNDLDDQLFGTFSRCQDIIRQEPQQANSRKELQDLLKVSSGGIVFTTIQKFLPEEDNREKYPVLSERDNIVVIADEAHRSQYGFAAKILNKDDKTLITYGYAKYLRDALPNASFIGFTGTPIEKADRSTPAVFGKYVDTYDIEQAVNDGATVRIYYESRLAKLELKPEERPKIDSEFEEVTEGEEVEGKEKLKSKWARVEKVAGAPMRIKRIAKDIVDHFEKRTSVLEGKGMIVCMSRRICVELYNEIVELRPEWKNSDDEKGAIKVVMTGSASDPKEWQEHIRNKIRRKRIGDNFKDPKHELRLIIVRDMFLTGYDAPSLHTMYLDKPMKGHTLMQAIARVNRVYPGKEGGLIVDYMGVGAELKKALMDYTASGGKGKPAFDQEKAVMMMVEKYEVVKDMFHGFNYRKFFELKPSERISFIPQAMEHILKEPGKKERYAREVTALLKAFSLAVPHDRAMKIKEEVGLFQAIKSAIAKTTETGKESQEEKFDSAIKQILSKAVISDRIIDIFEAAGIQKPELSILSDGFLAEVKDMPQKNLAFEALKKLLNDEIRFMSKRNLVQAKSFMEMLDKTIKKYTNRNVEAAQVIEELIELAKKVRAEKNRAKEQNMSEDELAFYDALEVNDSAVKILGDETLRKIAVELTQMIRNSVTIDWTQRESVQAAIRLNVKKILRKYGYPPDKEKKATETVLRQAELVAKNWVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR8</accession>
    <name>K0INR8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59849">
        <property type="protein sequence ID" value="AFU59849"/>
        <property type="gene ID" value="Ngar_c29310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29310"/>
    <dbReference type="HOGENOM" id="CLU_203622_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2931-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7401" checksum="63FAFF125C49E693" modified="2012-11-28" version="1">MFKVIVLIVGGIFLMTFGIYLLTNMDLSKFALPFFQLSDINWKAIGFVTIVGGIAIFGSAAVASKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU2</accession>
    <name>K0INU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59969">
        <property type="protein sequence ID" value="AFU59969"/>
        <property type="gene ID" value="Ngar_c30530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30530"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3023"/>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3053-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="19586" checksum="F947320A50DE4D8E" modified="2012-11-28" version="1">MPIDPDFPRNHQVIGKIKHADGEHFHYRWGPGAAKEAAENEEVKAAYEHRGEELVPLGVSGTMVAVDWDACVADGACIEACPVQVFQWYRTEHDVPAKDAHNQVFAGTGSSVKEERKDYTDKADPIREHDCIWCMACVSVCPPQAVKVDQSNLEFHEKASGTFNEALAKGSAPPPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ6</accession>
    <name>K0INZ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60239">
        <property type="protein sequence ID" value="AFU60239"/>
        <property type="gene ID" value="Ngar_c33240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33240"/>
    <dbReference type="HOGENOM" id="CLU_117488_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3324-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="21549" checksum="9D3F2C22E89B7C21" modified="2012-11-28" version="1">MQTSYARPALWDSVKLGAALGVGSAWAIFGLVLAAGAQLGLPPGTFYEMIGVSLGQSEEWPAIYLGFGLHMVTGAIIGIVYMMISDRTRYLRSFSTLKWFGTGLATGIAVWAVLFVPLHFIVVQPTLQNMLLMSTDPVMQQRAERLDQMSDSILYGALAMHLIFGSILGFLARIATSSRDVVQAERIGTAAGGVAKYDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6Z5</accession>
    <name>K0I6Z5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl1</name>
        <name evidence="8" type="synonym">rpl1p</name>
        <name evidence="8" type="ordered locus">Ngar_c00860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00860"/>
    <dbReference type="EnsemblBacteria" id="AFU57036">
        <property type="protein sequence ID" value="AFU57036"/>
        <property type="gene ID" value="Ngar_c00860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00860"/>
    <dbReference type="HOGENOM" id="CLU_062853_4_0_2"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_L1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_L1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="24506" checksum="30141642687DC24A" modified="2012-11-28" version="1">MVNNNQLLELVKKAREGATKRNFTQSAELTLVLKDIDVKKGFNLNEVVALPHKPSKVPRVCVIASGDMGSRARKAGIDTVMEPTELDRLGTNKREARKVVRAHDFFLADTAQMASIGRSLGQFLGPKGKMPTPLPYGAPVENIAGRFKNSVRVKAKNQLNVSAKIGDEKMEDNQLAENASAIIAAVEKKLPQGDKNIRNAMVKFTMGKAAKLTALKGKEKEKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7A8</accession>
    <name>K0I7A8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01970"/>
    <dbReference type="EnsemblBacteria" id="AFU57146">
        <property type="protein sequence ID" value="AFU57146"/>
        <property type="gene ID" value="Ngar_c01970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.197"/>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_2"/>
    <dbReference type="OMA" id="EVIWGPG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-197-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="125"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="27284" checksum="9A5931DFAB3D3924" modified="2012-11-28" version="1">MDLHTILDRFANGSLSLSDVEKEISIHAIEKIGDIAKLDVGREMRRGMPEIIFAENKEYRDIIRIALAAVRHNGQAVVSRIRKSELSKVTNALKKKGLLVEVGRNSTTLLASDKSFSRKKIMTGAKIGIMAAGTSDIGVAEEARLVAKAMGCEAIASYDVGIAGMHRLFPALKEMVAQNTGAIVVVAGMEGALASVVTSMVDVPVVGVPTSIGYGFGANGIAALASMLQSCTLGLAVVNIDNGVGAGAYAASIAKRMTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7L1</accession>
    <name>K0I7L1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57236">
        <property type="protein sequence ID" value="AFU57236"/>
        <property type="gene ID" value="Ngar_c02880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02880"/>
    <dbReference type="HOGENOM" id="CLU_1529153_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-288-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="167" mass="18369" checksum="6857EAE9DFFCCA35" modified="2012-11-28" version="1">MHNVILAFVLLLLASLLLACNNQAAAAKEQIVLEAASDQGTFTVEIMWTPDDIGSANAFDIRFIEPETGEEIEDMTYDISIYKGGDREVLRSDQTATRQEFTFDEPGSYTIMIDDIDGLGEWVEIPIQVTPEFPAGVLALIVAFGIVVAVIARRNNNSKNLFSQPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I850</accession>
    <name>K0I850_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57446">
        <property type="protein sequence ID" value="AFU57446"/>
        <property type="gene ID" value="Ngar_c05020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05020"/>
    <dbReference type="HOGENOM" id="CLU_2893366_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-500-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="6747" checksum="7358EF0D811BDCE5" modified="2012-11-28" version="1">MMVKREPTSINVNPDLWKDAKIEAIKRGITVTELFETALAKEIGKPVPSGKIEGAKIKGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8L2</accession>
    <name>K0I8L2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57621">
        <property type="protein sequence ID" value="AFU57621"/>
        <property type="gene ID" value="Ngar_c06780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06780"/>
    <dbReference type="HOGENOM" id="CLU_2044484_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-676-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="14214" checksum="F45AC4E155D0CD2D" modified="2012-11-28" version="1">MIKEEKVLAEQIKQVQKEVDELFGQYGGSIQVRFIRCGSPNCYCARRTKGHGPYYYLERRVSGKVQMIYLGKNKMDVNHYNNYHCKMSNLKKRLRAMKRRHQQLHGVIMSITQLVKTNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8W7</accession>
    <name>K0I8W7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c07480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07480"/>
    <dbReference type="EnsemblBacteria" id="AFU57691">
        <property type="protein sequence ID" value="AFU57691"/>
        <property type="gene ID" value="Ngar_c07480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07480"/>
    <dbReference type="HOGENOM" id="CLU_054750_4_0_2"/>
    <dbReference type="OMA" id="VLIHFMP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-746-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="232" mass="25289" checksum="A7436C67B89C5627" modified="2012-11-28" version="1">MAGFGSSTIFLPLALLFVDFETAIILTAIFHLFGNIGRITFFRQGFDKRIILQFGVPSVLLSLLGAILMGVFPQPLLKLILGVFLIVTSGSFLARPGLKFPANTGTFIAGGSITGFITALVGTGGALRATMLQGFNIEKVKYIATAATIALATDVTRIPVYISQGFLTEQYYVHIPILFGIALAGSFIGRRMVKRINQELFRRIILVAIILVSIKFIIDGFLILYLVVSYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I919</accession>
    <name>K0I919_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative diacylglycerol kinase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08440"/>
    <dbReference type="EnsemblBacteria" id="AFU57786">
        <property type="protein sequence ID" value="AFU57786"/>
        <property type="gene ID" value="Ngar_c08440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08440"/>
    <dbReference type="HOGENOM" id="CLU_1792189_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-842-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YegS_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="15490" checksum="00CDEF7DA85CF66A" modified="2012-11-28" version="1">MVKSRLASTVAAIVSTLPAYESNLCTISLDNNPRKTFDTKMTMAIVANGKFLGGGFVAAPDADMSDGLLDVVILKDSGSLKMLDELINLKSGDHFDDDNIMYAQASTVSIESKERDVTVTLDSEPIGVLPADFYIFHNALNVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I989</accession>
    <name>K0I989_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57896">
        <property type="protein sequence ID" value="AFU57896"/>
        <property type="gene ID" value="Ngar_c09540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09540"/>
    <dbReference type="HOGENOM" id="CLU_1674041_0_0_2"/>
    <dbReference type="OMA" id="KRRIQHY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-952-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="19255" checksum="DFF251E5AA3EA709" modified="2012-11-28" version="1">MRIKRVWIYKNTRPVVRVTGSHQRSCLFGAISLDGRRQLFRQYDWFDEDTFLDYLKQIHRKFPRCYLFLDKARQHHKSEKVKRYFHDHKDTLIPVWMPTASPEFMVLETCWQLSKDALLVMTYYPSFGDLKRRIQHYFRTKRFHLDMRKYLTEGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9E3</accession>
    <name>K0I9E3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">cheB</name>
        <name evidence="6" type="ordered locus">Ngar_c10190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10190"/>
    <dbReference type="EnsemblBacteria" id="AFU57961">
        <property type="protein sequence ID" value="AFU57961"/>
        <property type="gene ID" value="Ngar_c10190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.970"/>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_2"/>
    <dbReference type="OMA" id="MLEMHRA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="5">
        <location>
            <begin position="153"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="39176" checksum="BFCB5AB05B18F949" modified="2012-11-28" version="1">MVVNDSRMIREYLCNVIRSHNGFDLCETARDGEDALRKLDQADPDLILLDLEMPNLDGVTFIDKVMTRDRPIPIIVVSSYGDSGDDKNNNIIFECLDSGAVDFISLPSDSGITDRKKTSQDLIARIQAVSSAYPDALVPLKERKKESPVTCAPLYHSGNRKMIVIGSSTGGPRVVTDIFSKLPANLPASILIVQHMPPSFTSAFARHIGSASRIDVREAKEGDLLEQGSAYVAPGDYHTTVTQSGTIHLDKSPKRQGVRPSVNISMVSASDVFGPNTLGVLLSGMGQDGAFGMKMIKRRGGRTIAQDSTTSVVFGMPKAAYDLGAVDEMVPANRMAEAIVRILGEMESERKREGMQQYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAR4</accession>
    <name>K0IAR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14910"/>
    <dbReference type="EnsemblBacteria" id="AFU58426">
        <property type="protein sequence ID" value="AFU58426"/>
        <property type="gene ID" value="Ngar_c14910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14910"/>
    <dbReference type="HOGENOM" id="CLU_061999_1_1_2"/>
    <dbReference type="OMA" id="INPFVSI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1489-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="24011" checksum="A278C4012B46806A" modified="2012-11-28" version="1">MLNIKEDYHVHCNYNDHSSADLTVQNALKQAEKMGLKAIAFTEHVRRSSEWIPRYLAEVESAINSADDNKNAIKIIPGFEAKILADGSIDCPEYCAQKYFLVASFHTRYTDKKIWLNALEKAIENKNVDVIGHLFPENSFALEEDEVGRLARLMAANNKIVEINAKYHAPPNDWLKVFKRNGVRFHLGSDAHSLEAIGRFERVWDLIAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAR9</accession>
    <name>K0IAR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carbamoyl-phosphate synthase, large chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14960"/>
    <dbReference type="EnsemblBacteria" id="AFU58431">
        <property type="protein sequence ID" value="AFU58431"/>
        <property type="gene ID" value="Ngar_c14960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14960"/>
    <dbReference type="HOGENOM" id="CLU_052967_4_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1494-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="127"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="366" mass="40196" checksum="A8626FEB27686C37" modified="2012-11-28" version="1">MIANVLVTSAGGIVGQGIIKALKLSNKSAATSPVTYNIFGTDMNPLATGLYRCNTGMLVPPATSPDYIDFIIGVCKNNNISAIFVGSDGELLTLAAAREKIERESGAKVLSGPSDILSIARDKWKTYEFCKANNIPFADSALPPDSEQFVREFGFPVVVKPREGYGSVHFNIVHNRMQMEQVISEIEAAGWRPIIQRYLGHDIKHNLDGIDGANEFTTGITVDKTGKRVMSSISIKKILKAGQTHKALIDDFPGIRKPAEAVALKLNAAGPINVQAKLEGDTPVVFEINPRLSATCAMRAFAGVNEPDIIYRNFLRDEEIKVDSYQKLVCLRYLNEVYVPFSVYSRVLVDKEISNSERGSFIPDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBI3</accession>
    <name>K0IBI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58636">
        <property type="protein sequence ID" value="AFU58636"/>
        <property type="gene ID" value="Ngar_c17030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17030"/>
    <dbReference type="HOGENOM" id="CLU_1352148_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1701-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="22762" checksum="1DA84DB9015DF63C" modified="2012-11-28" version="1">MMLIEPAAEIEELKHHWQKIQELKRSILDKSDIQEISGKAYVKRSGWRKLQSAFAISDRIVSKEREDQDDGHFLWRVEVEAYHVRTGRSAMGIGTCSTKERKFAHPDHDILATAHTRAKNRAISDLIGLGELSFEEIDANPEPVASQHQPPAAPAPTIKKEEMCSCGHSRPLHISDGKALYCMQCVREGKEDVKCNLPIVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBJ2</accession>
    <name>K0IBJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58646">
        <property type="protein sequence ID" value="AFU58646"/>
        <property type="gene ID" value="Ngar_c17130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17130"/>
    <dbReference type="HOGENOM" id="CLU_2985803_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1711-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6461" checksum="7720590D5CE19BFB" modified="2012-11-28" version="1">MGTKKHRMTVGFDKGDIDFLQELGIFKSTGDGIRFAVKLMRLYSIPTLKAIKEKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBP6</accession>
    <name>K0IBP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56995">
        <property type="protein sequence ID" value="AFU56995"/>
        <property type="gene ID" value="Ngar_c00450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00450"/>
    <dbReference type="HOGENOM" id="CLU_2581529_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-45-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9069" checksum="658E22259620CC32" modified="2012-11-28" version="1">MFPHHSPKTSLNPLLAKVIKVQVTILVVLGFLSMVDLFVIFQPLFSWKLQIANFALEGIIFLDADLELSFDIKKKKDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC75</accession>
    <name>K0IC75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58961">
        <property type="protein sequence ID" value="AFU58961"/>
        <property type="gene ID" value="Ngar_c20290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20290"/>
    <dbReference type="HOGENOM" id="CLU_184936_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2027-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8942" checksum="8A7F0B21B0292504" modified="2012-11-28" version="1">MNVVYPQSDIVIAKTCGCSSGKQRVTYAFSADFHSLCMDKKDLLSAEIAACEKLSKYATAESESEVIAKEIAELKMALDLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICV6</accession>
    <name>K0ICV6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c22560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22560"/>
    <dbReference type="EnsemblBacteria" id="AFU59186">
        <property type="protein sequence ID" value="AFU59186"/>
        <property type="gene ID" value="Ngar_c22560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22560"/>
    <dbReference type="HOGENOM" id="CLU_2271131_0_0_2"/>
    <dbReference type="OMA" id="KFADSEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2254-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10098" checksum="ACF2A8C02A5802A0" modified="2012-11-28" version="1">MLFLPSGKRLWIVVGKDNEYWTDPDLGFCSCKDFYFTTLSGGDECYHLKSVRKAIEENRFTTIKFADSEYVGYLQAIAEDNVNLLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID35</accession>
    <name>K0ID35_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5">1.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gnd1</name>
        <name evidence="5" type="ordered locus">Ngar_c06320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06320"/>
    <dbReference type="EnsemblBacteria" id="AFU57575">
        <property type="protein sequence ID" value="AFU57575"/>
        <property type="gene ID" value="Ngar_c06320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.609"/>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_2"/>
    <dbReference type="OMA" id="NGYALMY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="311" mass="34514" checksum="D0BA61D446D013E5" modified="2012-11-28" version="1">MRQLGIVGLGKMGGNLAMQAHEKKIDVIGKARKSKPELEKQGIRVVTDYDSFARHLKQPRVVYLSLPAGPTVDTVLDELAAYLAKGDVVMDGGNSFYLDSIEREKRMWEKGIYFLDCGTSGGLEGARYGACFMVGGRQEGVRIAEPLLTALSVKDGYVHTGQPGSGHFVKLVHNGIEFGMLQSIGEGVELLRKSDFRLDLQKIFKNWSNGSVIRGWLVELMERGLREQGIDKVESYVEDTGEVNWLVQDAVSKEIPIPIISQAVMELFKSRMSESNAYKAIALMRHGFGGHPFGKDKDIAEERKTSRVHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID56</accession>
    <name>K0ID56_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57595">
        <property type="protein sequence ID" value="AFU57595"/>
        <property type="gene ID" value="Ngar_c06520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06520"/>
    <dbReference type="HOGENOM" id="CLU_1275362_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-650-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="216" mass="25894" checksum="488414A13CE2A14F" modified="2012-11-28" version="1">MTAPAIATIMLKEFWGSEIPWPLNSLVDGLFRAQMEVSFGHTLEIEPRLFIERDLHDFLTVTGYRQLYDYLYNVYSLEYSQHHLEPMDWELVGKYVHTPHWIEYEEKDRYRDRLPIRSHIGGDRPYRTISEYKLDATILKVRKTFEEWLDKGTLHIEPDIPSRRELKEAYSFFSSKAELRKRLDDYIENVRKELYACGIYYRANVLSHVVRRLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID75</accession>
    <name>K0ID75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59341">
        <property type="protein sequence ID" value="AFU59341"/>
        <property type="gene ID" value="Ngar_c24170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24170"/>
    <dbReference type="HOGENOM" id="CLU_468229_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2415-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="563" mass="63870" checksum="442A5993ED18FF50" modified="2012-11-28" version="1">MLGSRDYARLIISAMADGKPKSAQDIVNATSLERSKVWTALSKLWRAGLVLRTDRPVSENCKKFRGRHGATSNTRLYHLYVLNGDSTEPQDYSIDGRRFVRFSSEYSDKRGSKGEKSKARLILNFLKDNSDRAFYSTEIYNALKDRGVKMPDVMTAARRYERKGLLYIRGYQTHDSCSPFAEGYLVTWIDSSNKDETSALKDAVAKTNQALSNKASTNPVVERVLAIRNTTIAESELGRLVSFNLIRDKLGTTENEANTAVARAMQLYPGIKEVKLFGNFRYYYHESSMNGEVLNAALEMAKNYIRMSKGRANRIGHNWEACVEWFIDKFTVGAEFRMQNHRNNGNDGRMDPRRITLHLIKSVGDRRQNAEVDRVWTVTPSVFAKPITYVLECKWGIVRRKDLDDFFNVLKWSTDFGVDTPEGRQVKNGVIGVFAAGAFEDIHIKVNGKDGTEGEKITLAQYASRLNVQLLRASDFNQKLHDRQVPKEVTVQKICRAARNENDVRRMLDAIWDKPENAVKVLSDAITANSDVYRFEEELEEGKGKEKREVLPTELPSTAAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDQ5</accession>
    <name>K0IDQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57845">
        <property type="protein sequence ID" value="AFU57845"/>
        <property type="gene ID" value="Ngar_c09030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.861"/>
    <dbReference type="HOGENOM" id="CLU_036902_1_0_2"/>
    <dbReference type="OMA" id="EMGDGKQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-901-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="31889" checksum="95023D9BBFC8C6F2" modified="2012-11-28" version="1">MESSAVWYNIYQYLSEEKHFDVVLSNPIKTRAIASAKIKTDKLDAAKLADLLRGGYIAECYVPGRRIMDLRELVRHRAALVRMRTKLKNKVHGIMLMKGITIPDAPYPFTQKYNEKLKELNDYRINGYLRVIESLDLEIKDASDKIIQLAKNDEMVKLLMTIPGIGYYSALLIVGEIGDINRFPDSYHLCSYAGLVPSTHSSGGTTYNGRITKTGSKHLRWIMQECVYVHIRTAKDSNITQFYDRLAKKKGKSKAAVAAASKLLKIVYWVMKEKREYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDQ7</accession>
    <name>K0IDQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57850">
        <property type="protein sequence ID" value="AFU57850"/>
        <property type="gene ID" value="Ngar_c09080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09080"/>
    <dbReference type="HOGENOM" id="CLU_419581_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-906-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="653" mass="74059" checksum="823D648664414BCC" modified="2012-11-28" version="1">MTDNLIIFLTLPLFFAITSSFGWLVLSRTRIKKNPKLIEFPIYSLVGFSSILLILWLGLLSNLPLNALSIAICVISALGISYWVKTLRRDHTKKEANHLEYPDAYITLKKLSKSYSHQIAIIALAIFIIVFFSWFLVKMSVWSPAGDATSHGTIISLILSNNGRPESYQPISNASFDLWRYPLGYHVITYFFAFTFNIIPAISMVSMAVFISMLIPLLIFSSILSVSGRIFLAVSASLLAFLAPQFTSEASPVHDLLYSNILNGTYPSHTANLLIIGLVGILCFLKDSEIRPNLRHIILIMVISIAAFLTYYIYLVFIIFICIIIGGVLFDTKKPIILLAVVFVGLLIGQGWFTFSSDIISQTINDFKLRMKTYTVTKDDIDTIYLVIILAPFWLIFLKPDSLATGIILSMLTLFIPMLFNVFIPIDWQSLWMFPTRRIWPTLFGISIVASYVILANISKHYRVCALLRYTQYSLLAIGIAVMLIFAFYFNPGNWQVPTADDRRVMEWISNNVSRKDLVVNDMTFQGLFLTSVAAQNVTSEIAIVSQSFASDVPIDNEFAHRSLELTTIFLEPRNYQAHQALLQKYNASYIFVSSSQVYLDYWNPVLKGGILRPEYKYKTDLSQQDYLKLFDENPNLRLAFKSGESAVYKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV8</accession>
    <name>K0IDV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57003">
        <property type="protein sequence ID" value="AFU57003"/>
        <property type="gene ID" value="Ngar_c00530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00530"/>
    <dbReference type="HOGENOM" id="CLU_3323101_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-53-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="38" mass="4159" checksum="07043AAA2C1794E3" modified="2012-11-28" version="1">MLGFLTIGVLLFNPFILVVLGIAIVVIAAMMKNKKDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE08</accession>
    <name>K0IE08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c10530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10530"/>
    <dbReference type="EnsemblBacteria" id="AFU57995">
        <property type="protein sequence ID" value="AFU57995"/>
        <property type="gene ID" value="Ngar_c10530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10530"/>
    <dbReference type="HOGENOM" id="CLU_010363_0_3_2"/>
    <dbReference type="OMA" id="TNTQTFE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1051-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="32"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="319" mass="34525" checksum="AADC5C52E5A62834" modified="2012-11-28" version="1">MAILLATALLPIHAFATEEDGALKIVFIDVGQGDSTLIILPNGKTLLIDGGERDQDKTVLSALQEHNVSKIDVMVATHPHADHIGGLIGVIDAMDVGQIIDSGQVHTTQTFLDFVETIESNQIPLVSVHEGDSIELDPNIDIRVLNPPATLPDRAYNEEEFNNNSVVIKLTYGEFTAIFPGDIELETESRLSSKDIDVDILVASHHGSRGSNTAQYLEAASPEVIVIYAGADNDYGHPHDESLDRINAAGVQHIFRTDIDGTIVLTTNGSSDYTLETVESGKIVVVPEFEYALLITSISLISLIVLINSGRIWKSSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEH4</accession>
    <name>K0IEH4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02200"/>
    <dbReference type="EnsemblBacteria" id="AFU57168">
        <property type="protein sequence ID" value="AFU57168"/>
        <property type="gene ID" value="Ngar_c02200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02200"/>
    <dbReference type="HOGENOM" id="CLU_2505056_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-220-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9684" checksum="F1D25F0E5F3E30CE" modified="2012-11-28" version="1">MFKSLDFLYVPAPDIESSIQYYTQVLGGELLWKIHAYGVWVACVTLSKAEKPYILLADHIHKNDVMLIYQVENLENAIAQLKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEK0</accession>
    <name>K0IEK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57193">
        <property type="protein sequence ID" value="AFU57193"/>
        <property type="gene ID" value="Ngar_c02450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02450"/>
    <dbReference type="HOGENOM" id="CLU_090632_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-245-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="238" mass="25233" checksum="8D49F23C396CA57E" modified="2012-11-28" version="1">METLQTGRAFGLSIMAGLVAGGILAGINVALVRPYTAALADIELENLLAESEFFEEEFDDRLQSIYFSQLYGSVIVGLAAGAGAGVTFVVGRIRASPLKAALIIAGIAWFVLYVIPAVKYPPSPEATFDPEAAGIYQMLLAGYTAVSGLAALAIAFGFRKVKRKEKALGAAALYLVAIAGAFFVFPDFQSEDDSFLPQPIVSGWRSAISLSMTVFWFALGIICGLLWTYGSRGVGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEK2</accession>
    <name>K0IEK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59781">
        <property type="protein sequence ID" value="AFU59781"/>
        <property type="gene ID" value="Ngar_c28620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2836"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2862-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="1">
        <location>
            <begin position="85"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="218" mass="25288" checksum="4543FEAD8FFD9C4F" modified="2012-11-28" version="1">MTRHIRRFSKNIWVSKIQAKREVHSSTYPQYRGFRIRDNKLALSHIGAIKFKMHRIPIGKLKTCTIIIDIDQWYCYIATDDGIEEIDVKADTNKPVRIDVGLLNSLTLSNGKVIQNSLDFEAQVTKIKHLQKSLSRKQKDSKNREKVKISLAKACRKIRRQRDDFVHKASKLLADEYTLIVFEKLNINNMVKNHSLASAIMDICHLGKKLREYTLPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEV7</accession>
    <name>K0IEV7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58300">
        <property type="protein sequence ID" value="AFU58300"/>
        <property type="gene ID" value="Ngar_c13620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13620"/>
    <dbReference type="HOGENOM" id="CLU_843632_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1360-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="329" mass="37546" checksum="3AB82FB266DAE9BE" modified="2012-11-28" version="1">MGNIDISQYVMLDDQVPLDPEQFYNSFGHLQHPRTKKPVKELAPYQIKVWKAMLEQRRVLVVKTHKCGLSTSQLMADFQLAVLPSSHPLSTRGYDTLLVSQTKDIAKELLRTLRRMILHSKKYSKYLIDRPTEIEEFGSGHISYQKIMRDEQTKTSVIYIRNPEDETRPSRIIALGADNPGSIESWPNIHHIHISDITATIGDYSDSLNVAITRLANTGGTMVIESIPDFAGSTLHQLYEKYQARQSRLAIGQDFATFEITADEAVAAGVMTPEHLASERERLGPLFPRYYGAKFLSSGNAWYDESLIQYFEDDDDDEEEEETEWEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFQ4</accession>
    <name>K0IFQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60186">
        <property type="protein sequence ID" value="AFU60186"/>
        <property type="gene ID" value="Ngar_c32710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32710"/>
    <dbReference type="HOGENOM" id="CLU_2857219_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3271-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7221" checksum="3855BA9A26210495" modified="2012-11-28" version="1">MQSKDKTKVGDVDMSKIGDKAGIHSDDQARHLERGQEKEFEIIEGNETGSWQIKEKDEESASDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFY6</accession>
    <name>K0IFY6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57718">
        <property type="protein sequence ID" value="AFU57718"/>
        <property type="gene ID" value="Ngar_c07760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07760"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-774-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="10281" checksum="0DC2E036D3C8DFA6" modified="2012-11-28" version="1">MKYAYRTYVAARILDAVKNGAKTNSSIMHEAFVSYDALRRHLDVLIGSGLLQYFEPTRRYYQITEKGLQFLRLYNRAEEMICMASSCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG23</accession>
    <name>K0IG23_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PMT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c18020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18020"/>
    <dbReference type="EnsemblBacteria" id="AFU58735">
        <property type="protein sequence ID" value="AFU58735"/>
        <property type="gene ID" value="Ngar_c18020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18020"/>
    <dbReference type="HOGENOM" id="CLU_622037_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1800-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="8">
        <location>
            <begin position="47"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="522" mass="58808" checksum="75CE519738F036CB" modified="2012-11-28" version="1">MACTYFAAGVLCYALDSNSFAIVDRFCILLSVSFNKRYLLILIPLALSSFTHLWNATGFPDLFYDEGIYMRRAMNVLEHQMLQENLYYYDHPLFGQIFLAGLLALTNYPDSLNPSISAQSIESLYLVPKIWMGVLAVIDTFLIYKIADYKYGSSRIAFLASILFAVMPMTWLTRRILLESLLLPFLLSSILFALQLQRSHNKRQQQYFAMMLSGTCLGLAIFTKIPVFTMIPLIGFSVYTGSSKEKNQLRNVGLWFIPVVLIPMIWPAESISTGSFDNWVRGVLTQTQRHSDGITTAFAGFLITDPVLLALGILGFGYAILKKDLFVLLWVGPFLVFLWLIGYVQYFHVMPVLPVFCISAALWINDVINKVGPGRRLIQHGIVASIVVFGLASTTLLITTNVTSSQFEAAAFALSLADNDTTIIANPVYSWPYNFVFHVPHAMNDYRDVMYSAIPTDKVVLISDPHFRGSINEAPIVQTYNSTTSVRTFYGNARSYDPDLYPYTSMTLNYQGNDIDVRQKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG29</accession>
    <name>K0IG29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HTH-type transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c08210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08210"/>
    <dbReference type="EnsemblBacteria" id="AFU57763">
        <property type="protein sequence ID" value="AFU57763"/>
        <property type="gene ID" value="Ngar_c08210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08210"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="TAFILME"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-819-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="167" mass="18976" checksum="7886A133972C1C38" modified="2012-11-28" version="1">MPFPPDLLLDEINLKIIDILSRDASRPFVEIAKELEISDATVHMRVRRLMAAGIIRKFTIATDNRLLGYDHLAFMGINIKEGSSDEVTALLSQVDEILEIHEMHGRFDLLLKIRARNLDEMRDIVVNKIRRLPQITEAELMTVLKTIKEEQSVSLKRDISDATAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGH6</accession>
    <name>K0IGH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58905">
        <property type="protein sequence ID" value="AFU58905"/>
        <property type="gene ID" value="Ngar_c19730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19730"/>
    <dbReference type="HOGENOM" id="CLU_1575000_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1971-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="169" mass="18301" checksum="856DD23957348546" modified="2012-11-28" version="1">MAYIRLVAATKDKPAVAALAAAGIFLLMPVLQLVNTPLAFEIWFLDLYQKPPSSIAYLAFSVLFGMFISLYLYAKNKCFDCRPEKARAGFAGSVVGFMVGVCPACFSFIGVLLPLGPTLFLTSYSPVFTGISIAMVLFSIYKLGGLKRQVAQGTFWSNPGGRFDLPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN0</accession>
    <name>K0IGN0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp22</name>
        <name evidence="4" type="ordered locus">Ngar_c20480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20480"/>
    <dbReference type="EnsemblBacteria" id="AFU58980">
        <property type="protein sequence ID" value="AFU58980"/>
        <property type="gene ID" value="Ngar_c20480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20480"/>
    <dbReference type="HOGENOM" id="CLU_046737_12_4_2"/>
    <dbReference type="OMA" id="VYSERSH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="18419" checksum="4BD53D58E6C2EAAE" modified="2012-11-28" version="1">MTKSGKIAKREDKQLGYLDDIFENFRREVESALKPWHAGFRFPSLFDGETRVPLCDMADRGDRYELQVEVPGIEKDKVNVKATGNSVEISAEQSEKTEEKRKDYVYSERSHRSFYRKIPVPEEIVPSKIDAKMNNGILVVKLPKKNPTKSKEEATKVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR5</accession>
    <name>K0IGR5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="7">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisS</name>
        <name evidence="9" type="ordered locus">Ngar_c20940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20940"/>
    <dbReference type="EnsemblBacteria" id="AFU59025">
        <property type="protein sequence ID" value="AFU59025"/>
        <property type="gene ID" value="Ngar_c20940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2074"/>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_2"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="34"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="456" mass="50674" checksum="4C3C643A563D94AE" modified="2012-11-28" version="1">MLALSQQTVIIRSSQNLNANALLATGVVKLELPRGMRDLEADEFANISYVRDKFFETARLFNFQLAEPSPLEMLATLEAKSGAAISNEIYAFKDKGGRDVALRFDLTIGLTRYVASRRDLKMPVKMAAFAGVWRYDEPQAGRYRYFHQWDVEVYGPFSQESDAEVIEFVSIFFKRLGLKVVIEVNDRQLIEQYIKTKLRITNEEAMLEMFRAVDKVPKKGAQAVLQEYKDRIEPAKLQALIELSKVKGTADEVAGKAEDVRGLESWQKFAGLMDSLKTRKVEEARVNLGIVRGLDYYSGVVFEAFDPSSDSGALVGGGRYDRLTEVFGRKDIGATGVAGGVERIVMALQRHSILKQQAKALVYVVYASDDVRNKAVEIASALRSADITTDYDILGRALRKQLDDASMKGAALAIIVASNEIAAGQVIVRSMRDGTENKYPASNLAEMLHKMLRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH25</accession>
    <name>K0IH25_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22350"/>
    <dbReference type="EnsemblBacteria" id="AFU59165">
        <property type="protein sequence ID" value="AFU59165"/>
        <property type="gene ID" value="Ngar_c22350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22350"/>
    <dbReference type="HOGENOM" id="CLU_076311_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2233-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="24063" checksum="C2E511B3150579EB" modified="2012-11-28" version="1">MVSWWPGDWSAGDIWSNNDGILQNGASFGPGAVGGGGQAFKLDGVDDYIEIPSTDIADTFTVDFWLNPEWSTRYEHLISNHYTNNGSFGARYLNYDALEYWQDGQVRFVQDVSGGSQNTITIIQPNTWSHIALVYNGSGIQVYVNGDEQSSIPTSGSVPHSETFNNALRIGSSIPHESSYFQGLIDDIEIYNRPLFQPEIRAIFEGGKCQKRGPRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH32</accession>
    <name>K0IH32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57127">
        <property type="protein sequence ID" value="AFU57127"/>
        <property type="gene ID" value="Ngar_c01780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01780"/>
    <dbReference type="HOGENOM" id="CLU_176749_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-178-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8571" checksum="6F69A4DF9D0E44D7" modified="2012-11-28" version="1">MAALEQEFRKRAGETIENYLSILGGTFPNRQNLVNTWKYEHKDDFMYGLRSTDGLIVGYFRGIYDRVPSDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHA4</accession>
    <name>K0IHA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58258">
        <property type="protein sequence ID" value="AFU58258"/>
        <property type="gene ID" value="Ngar_c13200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13200"/>
    <dbReference type="HOGENOM" id="CLU_2597863_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1318-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8263" checksum="BB2A5D60EBFA89E2" modified="2012-11-28" version="1">MATGMYAGALIAKSYESTQAGKFTLAEIISFGSLGWFAGTMGTGILKEAFGGEINVVFAFIGLMLLGGFFISLLMGRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB0</accession>
    <name>K0IHB0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ERCC4-type nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23800"/>
    <dbReference type="EnsemblBacteria" id="AFU59305">
        <property type="protein sequence ID" value="AFU59305"/>
        <property type="gene ID" value="Ngar_c23800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23800"/>
    <dbReference type="HOGENOM" id="CLU_101253_0_0_2"/>
    <dbReference type="OMA" id="IIEGDLW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2378-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="26964" checksum="1B5F1B6D4B13A81F" modified="2012-11-28" version="1">MPATRIVVDEREKNSGIPELLKNAGAVIDFAQLKVGDYIVSPETAVERKTVRDLISSIYDGRLFVQCSDLVKHYQKPLLVVQGNIAELTEIPEDAEDMDVKKLAERMPLAYDALATVATEFRIPIIHTPSADQTAQLLVTLVNKSLQEGKATGPLLRKIKKENPVYIQQLSVLSSVPGVGEKLAARMLEKFHTPKRALNASVAELATIPGFGLARAERVRKVLDSPNNVKQIVQRTLFEQDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB3</accession>
    <name>K0IHB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58278">
        <property type="protein sequence ID" value="AFU58278"/>
        <property type="gene ID" value="Ngar_c13400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13400"/>
    <dbReference type="HOGENOM" id="CLU_1891501_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1338-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15287" checksum="81441280EB428163" modified="2012-11-28" version="1">MGREAEIDKMLKELHASYLKDNEHDEGDLIYYRINYRLADTFGMTREEAERLHSGYHVGNPRHISQGFCEKCGSMVTIIPVIYGIQESDMERMKAAEMQGRLIIGDMATVRQGSKVAMFGCKECRTLLSKYGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHI7</accession>
    <name>K0IHI7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03240</name>
        <name evidence="2" type="ordered locus">Ngar_c03530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57272">
        <property type="protein sequence ID" value="AFU57272"/>
        <property type="gene ID" value="Ngar_c03240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57301">
        <property type="protein sequence ID" value="AFU57301"/>
        <property type="gene ID" value="Ngar_c03530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03240"/>
    <dbReference type="KEGG" id="nga:Ngar_c03530"/>
    <dbReference type="HOGENOM" id="CLU_2968565_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-324-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6453" checksum="CABEA55D10A36069" modified="2012-11-28" version="1">MQYLIFTATFPLEGKKISGDHVKQLAEIFRQQFASMGAEVEITVQSDPVEQPPTTELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN7</accession>
    <name>K0IHN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58443">
        <property type="protein sequence ID" value="AFU58443"/>
        <property type="gene ID" value="Ngar_c15080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15080"/>
    <dbReference type="HOGENOM" id="CLU_2695893_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1506-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8694" checksum="9E400BFA0E31779A" modified="2012-11-28" version="1">MVSDATESGSNESYDMTPQRIRDYYGVVMDFERIANWFRWAQQNNRQMPKDRVDTFIQTFNLLDPRESIARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHP6</accession>
    <name>K0IHP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb6</name>
        <name evidence="6" type="ordered locus">Ngar_c15290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15290"/>
    <dbReference type="EnsemblBacteria" id="AFU58463">
        <property type="protein sequence ID" value="AFU58463"/>
        <property type="gene ID" value="Ngar_c15290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1490"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="RTMVMEM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="340" mass="37605" checksum="5E9C2F0DAD4AD1B6" modified="2012-11-28" version="1">MTSAEYYTQCSECGANLIQDHSKGEYICERCGCVMMDQVEDFGRESNATDFEEKSKNMRASGSTSFALHDYGLRTEIAYGSKDYAGKSIDYQMAETMNSIRKWHIRSRIVSAQERRLSNVLTKINEICAAMSLPKLLVETSAILYRNYESSCEAKGKSIACMAAATIYLACKKCSVVRSLEEIVKATGVTDQDRSSVKLASKYYRMMVMEMGVFTEQQPPAQAASTPQQPSPAVSLAIDYYISKLANMAKIDTKVERLAIDIAHKTDDHLLADGKAPNGLAAAYIYIASIFLGVNILQRDVSSLSGVTEVTIRNRCKDILTNFKMTVTVKPQQVRPGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX9</accession>
    <name>K0IHX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dusP</name>
        <name evidence="8" type="ordered locus">Ngar_c05790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05790"/>
    <dbReference type="EnsemblBacteria" id="AFU57522">
        <property type="protein sequence ID" value="AFU57522"/>
        <property type="gene ID" value="Ngar_c05790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05790"/>
    <dbReference type="HOGENOM" id="CLU_047330_4_2_2"/>
    <dbReference type="OMA" id="CYLVKEQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026067">
        <property type="entry name" value="Dual_phosphatase_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339:SF26">
        <property type="entry name" value="PTHR23339:SF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="7">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="18516" checksum="320C4FD62732F413" modified="2012-11-28" version="1">MTKIGDAYRRLHGMVTDRPTNFSWVIEGKLAGCGLPVSEDEFGWVIDQGIRSIVTVREVPLPSDWFNGSDIDYLHLAVEDFGAPSIEELAQAVDFIDQQISSGRPVMVHCAAGKGRTGAVLAAYLVKKQNLAADQAIDMIRNMRPGSVQSISQETAVLMYEKYLKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0II26</accession>
    <name>K0II26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59580">
        <property type="protein sequence ID" value="AFU59580"/>
        <property type="gene ID" value="Ngar_c26590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26590"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2659-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14578" checksum="BD313292DEDA904D" modified="2012-11-28" version="1">MITQTSTTRKSVLVVDDEPDVLAIIKSSLQKSGFEVQGFTDSILALEHFQQHSTSYDIVLSDIRMPGMNGFKFARSVRAANSEIRIFLMTAFEMHKSELEKVLPSVRVDQIIQKPVSMREMVTTIEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0II36</accession>
    <name>K0II36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c26690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26690"/>
    <dbReference type="EnsemblBacteria" id="AFU59590">
        <property type="protein sequence ID" value="AFU59590"/>
        <property type="gene ID" value="Ngar_c26690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26690"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2645"/>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="YARTQSF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2669-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="259"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="937" mass="105643" checksum="C2A3CCC0E04417CC" modified="2012-11-28" version="1">MKDQARNKNENSSAPEQLQTLKSDHAEEQLTIEKFRKEGFTSLTTIQRKALPVIARKVNCLLVAPTGSGKTEAAVMPVFTMLAHQREVPAKTIRAIYITPLRALNNDVLRRVVRYAQSEGLRVEIRHGDTTVLARKKIVKDPPDVLITTPESLAVVLTSEKMLAALKGLQWVIVDEVHELVANERGAHLSLSLERLQAASSSQHVARIGLSATVGNLKQTAQFVSGTGRRHAVLVDTTSRGYDIDVRFVKGSLNNVAHFVIEYVKKEKVEGSILLFTNTRDEAEYLGTILKNQGDIKVDVHHGSLSKEMREETEHTLRSGEAGIVVCTSSLELGLDIGSVDLVIHYGSPRQVSKLMQRIGRSRHRQRSFAKGLVVTNNADDEIEALAIIRRMKKGSIEEQKMHEGALDVMAHHLVGLAMQTRDPVKVDYAYDLMTRAYPFRNVSLFDVESCLDILASHNVIKYDRDNRTYVRRIKAYKYYFENLSMIPHVLKFEVIDSISKRRIGTLDQQFVGDYGEKGNVFVLKGSQWRVLSVDEGRLVVNVEPLRGAAINIPYWVGEMIPVDYKTAEEVGEIRNQAANDAIKLSTPIMDETKKALKVIPDSKNIVVESYGARNMLVIHSVFGSKVNNTLASLLSTILSSQLGYIVESRSDAYRIMLTSSARIVQGKLEAVLSDVYDLEPVIIAALTGTHNINWKVWMVAKRFGMISREAVYDKKVARMIYDRYSKTPVSAESIRELVHDKYDIARTQKVLDDIKQKKIKIHWLEVTEFSDLAKTIIEHSGKMAGAMPLSVEKGVIELIKERLEKTKHRLVCIRCGKWERVMETKYVPEEISCPYCRSRLITATFWSDDEMSRVIRTRLAGGKLTAEQNHKFERAWKVASLVNNFGKKAIIVLSGHGVGADTAARILRNYIDEEQVYKSIYEAERQYVITRGFWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0II37</accession>
    <name>K0II37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, 2Fe-2S and FAD/NAD(P) binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c06990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06990"/>
    <dbReference type="EnsemblBacteria" id="AFU57642">
        <property type="protein sequence ID" value="AFU57642"/>
        <property type="gene ID" value="Ngar_c06990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06990"/>
    <dbReference type="HOGENOM" id="CLU_709037_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-697-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="392" mass="44415" checksum="B023A2D12BFC7DEC" modified="2012-11-28" version="1">MAKEGGYQKVASKNDLKEGGLLRVEPNGKPIVLARVNGKVYAMDAVCSHEGGPLEDGTLEGYELKCPWHYAIFDVRNAKVSDQTVWATDLQSYPVKVDEATGDIMVSLQTTKPADGGGREATVQQQAGQEEEQDSDTLQKKYYEEEERRAADNKLSLELLSKEKLEGTDIMTFKFSRERIDYIAGQYAYFKLDGVQNDSKGPIRHFSIASSPTEQDYVMISTRIRRTPYKQRLALLQEGTKITAWGPEGEFVLQEDRPAVFLSGGIGVTPFRSMIKYATDKQLPVKITMFDSNKTQQDILYKDEFDSWANQNKNLKVIYTVTEEEQHDASWSGERGRIDKSMLERHLTRDEIGEAVFYICGPPGMLKAMQELLQKEMQIPKDRLKVEVFTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0II73</accession>
    <name>K0II73_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c07240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07240"/>
    <dbReference type="EnsemblBacteria" id="AFU57667">
        <property type="protein sequence ID" value="AFU57667"/>
        <property type="gene ID" value="Ngar_c07240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07240"/>
    <dbReference type="HOGENOM" id="CLU_881677_0_0_2"/>
    <dbReference type="OMA" id="NICIYMA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-722-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="35"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="321" mass="36960" checksum="B8F86CF86D20620D" modified="2012-11-28" version="1">MVDLIYGRGITDLLREMPFYISIFKKMTAYKLFHIKQPMYGSVDVNNVCNLHCTHCYWWLNRKEERDITVEDWRKIIKEKFNKQHIFVTTLVGGEPTLRSDIIELFCKEMPKRICVVTNATFPLKRYDGLYFYWVSMDGTEEVHDRIRGKGSYAKTRKNILDYISGPDRNGKPAWKDIWITMTINSQNYMTVEDLAEEWRGKINKIGFQFHTPFAKGDPLMLPFGELRNSVVDKLIALKKKYPNYIVNPISQMSLMKGNWGGVGTTPVDCPSWAILSLDHMGRVKQPCCIGSADPKSMKPICEECGLGCYSILVAQGIRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC3</accession>
    <name>K0IIC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17850"/>
    <dbReference type="EnsemblBacteria" id="AFU58718">
        <property type="protein sequence ID" value="AFU58718"/>
        <property type="gene ID" value="Ngar_c17850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17850"/>
    <dbReference type="HOGENOM" id="CLU_060247_0_0_2"/>
    <dbReference type="OMA" id="FGHTTRC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1783-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="207"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="370" mass="40472" checksum="812842327AEDB751" modified="2012-11-28" version="1">MVADQLREGGSEVQFSSYGEAASYVSLRGYKCVTVAAVEFAWSMEGGFSVKNSLANIPLWFANFSKQVNQETRNMTACNPDIVVSDSRLSPLVAARLLKIPSIVVLNQVKLLLSPRLRELAVSRLFENMVGEFLGSMWTMADRILVPDLPPPYTIAAHNIWEVGSAAQKLEYIGFASPKPHVSKEQVDKVADSLGLDRSRPVVFIHVSGPAQTRPALIRVALEAVKKLDPKIQFVISEGNPKGESEPRRIGESGWYYGWCPVRDEIFALSDLLVLRGGHVALSQAIQFGKPVVTVPIENHGEQLGNSAKVAELGMGVMLHPKGLKPEQLADAISQVLGNAQYRNKAAELQSLTENLNGIDNVAQIVRSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF0</accession>
    <name>K0IIF0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ordered locus">Ngar_c18450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18450"/>
    <dbReference type="EnsemblBacteria" id="AFU58778">
        <property type="protein sequence ID" value="AFU58778"/>
        <property type="gene ID" value="Ngar_c18450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1827"/>
    <dbReference type="HOGENOM" id="CLU_047382_0_0_2"/>
    <dbReference type="OMA" id="FFLPDKC"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="316" mass="35104" checksum="36EC3A4D21F585BC" modified="2012-11-28" version="1">MTMLDLDYKRKVVALKEQKNAVILAHNYQLPEVQDVADFIGDSLALSKNAATTDADVIVFCGVHFMAETASILCPEKKVLIPDLEAGCSLASTINVHELQAWKAEHPDAVVVSYVNTTADVKALSDYCCTSSNAVKVVNSIPRDREVLFLPDLFLGSYVAEVTKRKNMYIWPGECHVHAGIKADDINKMLATFKNADFLVHPECSCTSSAMYHMSKGDLAKTGHILSTEGMMKHARASDAKQFVVATETGILYRMQKENPDKEFIPIKRDAVCKYMKKITLEKVYNSLAHNVYEVKVPKDVADRARLAIDRMLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH7</accession>
    <name>K0IIH7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57867">
        <property type="protein sequence ID" value="AFU57867"/>
        <property type="gene ID" value="Ngar_c09250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09250"/>
    <dbReference type="HOGENOM" id="CLU_182718_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-923-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="11209" checksum="FF76436CB8D4CD8E" modified="2012-11-28" version="1">MTLDVGNVTEKGQVTIPKHLRKKYKIDDKVLFVDAGEGVLVRRVPKLSELKGILKDSKIDFDRIRQEERRIEAAREQRLMSIVERSRKHRQQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS4</accession>
    <name>K0IIS4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29370"/>
    <dbReference type="EnsemblBacteria" id="AFU59855">
        <property type="protein sequence ID" value="AFU59855"/>
        <property type="gene ID" value="Ngar_c29370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29370"/>
    <dbReference type="HOGENOM" id="CLU_1922676_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2937-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="15220" checksum="60AE9420B3A7395B" modified="2012-11-28" version="1">MGPAKMSDLLDAISDDASLELFKLVALTNGPSNVLRSNMKITRKQYYSRLFKLVECGLVKRKDNKYFLTTLGKVMYDAQATIENALNNYWKIKAVDSLEIAEGIPAEEQKKLIETLIHDQGIKSILTNNTTTYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW4</accession>
    <name>K0IIW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58067">
        <property type="protein sequence ID" value="AFU58067"/>
        <property type="gene ID" value="Ngar_c11250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11250"/>
    <dbReference type="HOGENOM" id="CLU_3282982_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1123-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="40" mass="4466" checksum="903FF404A39CCAE0" modified="2012-11-28" version="1">MYFTTAPIVIGRDSAFVIVLAVVGTILFAYEAFKVWQQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ1</accession>
    <name>K0IIZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59960">
        <property type="protein sequence ID" value="AFU59960"/>
        <property type="gene ID" value="Ngar_c30440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30440"/>
    <dbReference type="HOGENOM" id="CLU_2285140_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3044-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="10506" checksum="9D3E41A717F8CBC8" modified="2012-11-28" version="1">MLEANKTNLSLASGVEGFGFLGGNISNGVIANITNNGAIKPFFATRLNFEPYARIPIDTKAGALTTADVPQGTFAVIHDTTGGTYKLYANISGTLRSVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ3</accession>
    <name>K0IIZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30490"/>
    <dbReference type="EnsemblBacteria" id="AFU59965">
        <property type="protein sequence ID" value="AFU59965"/>
        <property type="gene ID" value="Ngar_c30490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3018"/>
    <dbReference type="HOGENOM" id="CLU_040971_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3049-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="400" mass="45705" checksum="6D9865C2A2A30464" modified="2012-11-28" version="1">MNGKKVLIVGIDGYIGWSLAMHLATRGHSVAGIDNYSRRRNVAKVGSVSATPIREMDERIHVFNMAYPDARGAIAFKEGDLLDYSFARDYIKWFKPDTIVHLGEQPSAPFSMVDREHAVYTQHNNVIGNLNLLYAIKEVVPDCHLLKLGTMGEYGYDTELEIPEGFFEIEYKGKKATIPFPRMAGSWYHWSKVHDSNNIMFACRLWGLRSTDVMQGIVYGTRTKQMILDELLTRFDFDECFGTAINRFCAQAAIGHKLTPYGKGGQTRGYLALTDSIQCLTIATENPPEKGEYRVFNQLDTVYKINDLAKTVQQVAGKKGMDVEIEPVDNPRVEKEEHHYKVKAEKLRNLGFRPTRTLEEEVDIMLTDLMRFKKRILAKKEVIMPKPYWKQVSQPPILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ24</accession>
    <name>K0IJ24_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoD2</name>
        <name evidence="7" type="ordered locus">Ngar_c12070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12070"/>
    <dbReference type="EnsemblBacteria" id="AFU58147">
        <property type="protein sequence ID" value="AFU58147"/>
        <property type="gene ID" value="Ngar_c12070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1153"/>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_2"/>
    <dbReference type="OMA" id="RDSHTIW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="114"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="359" mass="40639" checksum="D70AA2004503A406" modified="2012-11-28" version="1">MTLSIGPQHPGAGHMRIIVVVDGDIIVHADPDVGYVHRGEEKMSEYRTFIQNVPHIERPVIHDSSNILYSYCLAVEQLLGVQVPERGQYLRAIMSEIDRIHYTLYWLAILGIFLGHSTMFMWPAADRELFVELADMASGNRITHAWLVPGGVRNDLPEGFSDKAEKFLSYFEKRLVEYDKIFYDNPLFRQRSEGVGVLTRQNAIVYGTTGSVARASGVRFDVRKNEPYEVYNKLDFEVSVSNTGDSFARSILPIYDVRQSINIIRQCLKNMPKEGPVRAKLQPNPRGPPGEAYARVESGRGALGHYMVSDGTAKAYRHKISVPSVRNLLVLPHLLEGAKLADLPMIYWSLNIWPIEIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ47</accession>
    <name>K0IJ47_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative gas vesicle synthesis protein GvpL_GvpF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c22030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22030"/>
    <dbReference type="EnsemblBacteria" id="AFU59133">
        <property type="protein sequence ID" value="AFU59133"/>
        <property type="gene ID" value="Ngar_c22030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2182"/>
    <dbReference type="HOGENOM" id="CLU_065736_3_0_2"/>
    <dbReference type="OMA" id="YHAKLTS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2201-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="248" mass="28214" checksum="392FDB3A2B7F1F6B" modified="2012-11-28" version="1">MVDGRYIYCIIDWEEKRPIGNFGNIGIGENTVYTIYYKDIAAVVSTIPFKQMESNLNDIVAHQRVVEAAREANTVLPVRFGVILKNEAGIKKLLASSYKDYHAKLTSLRGKDEIGIKVLLNKSSLKKIREQAEQSSEEIRKIKQEISSAKPGTSYFLKLRLEDAVKNETLMKIDKMVGEINDSLAEVAVDKRLLKNDVAEIVLNAAYLVERNKIQIFDAKVKELRERFEKEGIMTLHRSGPWAPYSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ48</accession>
    <name>K0IJ48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12520"/>
    <dbReference type="EnsemblBacteria" id="AFU58192">
        <property type="protein sequence ID" value="AFU58192"/>
        <property type="gene ID" value="Ngar_c12520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12520"/>
    <dbReference type="HOGENOM" id="CLU_1782540_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1250-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAMP" evidence="1">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="15905" checksum="E303AF1DD51C5306" modified="2012-11-28" version="1">MGKEIFLLKDSGVSEQVLEQKFGQLDDPLDAFTEELNNEELLISQYAESSLMVVKDDIQLTLNVTAALASVVAEIATGTGIYNTYSISKPISKLRNAAREIGSGNFDVEIPATKSADEIGELSAQFRKMKEDLMHKEEMQTSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ62</accession>
    <name>K0IJ62_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58242">
        <property type="protein sequence ID" value="AFU58242"/>
        <property type="gene ID" value="Ngar_c13040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13040"/>
    <dbReference type="HOGENOM" id="CLU_119362_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1302-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16905" checksum="6D575F5803A53E75" modified="2012-11-28" version="1">MPGTTKVLSDEQDIIKAIERFQANTKKFWGACVDSSLPSFSVGKVKQWYIKAKKRGVRIQYITEITKDNLPYGKEIMQFAELRHLCGVRGNFAVSDTEYVAGVMRGSTLSNLVQSDVKELVRQQRHVFYTLWKQAVPAKERIAPLAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE3</accession>
    <name>K0IJE3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">metG</name>
        <name evidence="11" type="ordered locus">Ngar_c32290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32290"/>
    <dbReference type="EnsemblBacteria" id="AFU60145">
        <property type="protein sequence ID" value="AFU60145"/>
        <property type="gene ID" value="Ngar_c32290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3220"/>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_2"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="9"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="10">
        <location>
            <begin position="410"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU60145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="551" mass="63157" checksum="3AC7F0D7B752056A" modified="2012-11-28" version="1">MPDSTKSAVVTSALPYANGEIHLGHIASTYLPADIFTRFSRLNGVKAYHICATDDFGTPILIRAEKEKKSPEEYVALWNRRDYEDFSSLGISFDFFYKTSSKENVEFVQYVFKKLQKNGHIYDQNVIQFYCTFDDKFLPDRYVIGKCPYCGAENQYSDLCEKCGRVPDQILEPKCAICGRPPVKKESKHYFFRLSSFGEKLKEWLSANQNLQPEVRNYVINWINEGLQDWDITRDLSWGVPIPGAEGKVFYGWFDNHLCYISSLVKFISDKKGGDGKKFWNESDIYHFIGKDIVYHHYLFLPAMRLGIDSEYKLPDYIPTRGHLMLQNQKISKSRNWYIGLRDFTSAFNPDYLRFYIASVVTYSQDDLNFDFDAFYERINNELIANVGNFVNRALSFTQKSFGGKVPEPANIDDSLGKELAAAVDEAGSLLAGNEIDKALKRVLKYSSFMNQYFQANTPWANKDTANTTLYVSVNAVRSLAILLEPFIPFSCEKIWSQLKMGGGSVHEQAWESAKDLRAVAPGHELGKVEPIFRKIEAKEIEQWKNKLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG1</accession>
    <name>K0IJG1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23680"/>
    <dbReference type="EnsemblBacteria" id="AFU59293">
        <property type="protein sequence ID" value="AFU59293"/>
        <property type="gene ID" value="Ngar_c23680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2340"/>
    <dbReference type="HOGENOM" id="CLU_031618_1_3_2"/>
    <dbReference type="OMA" id="QRPGHVP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2366-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="284" mass="32608" checksum="2C3E4CA25D139C05" modified="2012-11-28" version="1">MTSGYAHPEVLCETDWVASNLKNGSIRILEVDYDPENAYRQGHVPGAHLVWWKRDINDPVRRDIINKQQFEALMSRVGATPDTELVLYGDFNNWFAAFAFWVFQYYGHKKLKIMNGGRKKWELEKREYTKDEPTVQPTKYVARPPDEGVRAYMPDVRRAIERAEQTVLVDVRSPKEFTGEITAPPEYPMEHAQRGGHIPGAKNIPWAQAVNDANGTFKSADELKALYEGKGVTPDKHVIAYCRIGERSSHTWFVLKYLLGYPSVRNYDGSWTEWGNMIGNPIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJS5</accession>
    <name>K0IJS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34200"/>
    <dbReference type="EnsemblBacteria" id="AFU60335">
        <property type="protein sequence ID" value="AFU60335"/>
        <property type="gene ID" value="Ngar_c34200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34200"/>
    <dbReference type="HOGENOM" id="CLU_2010162_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3421-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="SSF90112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="13581" checksum="8CD27E2C6A5441FC" modified="2012-11-28" version="1">MANCQVLIIIITTIAMLAFWMSPTNFPPRIGLAASTLLAAVAAHLTAANQLPPIGYLTLIDKLMIVVYALFLNNLISMVMQMRLVDHKQEEKAVKVNAKMRKLMPVIIGVLLAVLIPFDLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT8</accession>
    <name>K0IJT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60355">
        <property type="protein sequence ID" value="AFU60355"/>
        <property type="gene ID" value="Ngar_c34400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34400"/>
    <dbReference type="HOGENOM" id="CLU_1598935_0_0_2"/>
    <dbReference type="OMA" id="VANAYIG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3441-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="161" mass="18650" checksum="0305398E92C086A7" modified="2012-11-28" version="1">MQFRERIANLKDFNEAFELVKSVVLQKFRMHRAGLSLILQMMPSNLGAYHMLGSNAIVMNSYLLAAVKKIACSTEEYNSYMFMVLAHEYLHSLGIVDENTVRQMTFELCKWMLGDDHTATKMAKEDPSTIYPELRSLVQSQFSSDFQVVRNFDRSNQTYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK37</accession>
    <name>K0IK37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RPA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26670"/>
    <dbReference type="EnsemblBacteria" id="AFU59588">
        <property type="protein sequence ID" value="AFU59588"/>
        <property type="gene ID" value="Ngar_c26670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2642"/>
    <dbReference type="HOGENOM" id="CLU_577000_0_0_2"/>
    <dbReference type="OMA" id="ECMPSKV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2667-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="473" mass="51310" checksum="DA81726DF8F4509A" modified="2012-11-28" version="1">MLETMLRQRPELSPEQIRDLIDEKKRKVGAGYLTDQGALFLVAADLGISFDNVPKVQAGLKDIYVGAKDVTVTGRIMNIYPVHTFTKRDSNEQAATRTIVVYDKDARVKVKLWDKQVNLPDEMGLQAGDIIKIIKGYVRSGLDGKPVINLGSYSAIETVRGDDPAIPSIDSLNSTIDTITGPQDSAVITGTISANPRLSEFVNARGEASKSLQMQVSNDAGTRTLRAVIWNVDETRLPKVFKTGAKVRMIGVKVKQGNPQYGNGDFEIHGDEGTILQFSNSQEDVEVMPLRIVSVGEETGRGSFLCLAADRAGRTFVLTVDNSLASSDQLSAGAMIECVPSRIFGNSVVLSKDDSYIRVTDDDASFPKLTKFEKKIKDIQVSQDPCIVEAIVLQVPETADVTTKMGETVPVTSTLLGDDTGEIRLVGWRNQSASVNKLSVGDRVRLAGVTTGAGREGKAELTLRPYSSVTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKR8</accession>
    <name>K0IKR8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59933">
        <property type="protein sequence ID" value="AFU59933"/>
        <property type="gene ID" value="Ngar_c30160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30160"/>
    <dbReference type="HOGENOM" id="CLU_3039184_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3016-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6341" checksum="4ED43F1158027BF6" modified="2012-11-28" version="1">MVRIAKRLVRYNVADGRASEKGMQGRMQYSCEKCGKKFGAWKHLRQHKVESHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS6</accession>
    <name>K0IKS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59948">
        <property type="protein sequence ID" value="AFU59948"/>
        <property type="gene ID" value="Ngar_c30320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3002"/>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="OMA" id="WEALENY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3032-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="385" mass="43543" checksum="FFFDBD646C076EA4" modified="2012-11-28" version="1">MNIGVVHHSLDGKGGSGRLAINTIELLKDMGFYVILIICQRPNLEKLKTTYNKDIHVDRIKALFPAQIRAFGIYQRMLTLIPAALTNVDLLISTHGDLLPYHITNRCPLISYCHYPTIALSMDGGASRYTNSLLWRSYFAPYERMTRYLSKPAHVRGRVLTNSKFSKNAITRLYPDIEPTIVYPSADTKSFKKALMSDKREDKILVLCRFTPEKSIENALILAKKLHTKTTIIGSLIPSNRYYFDHLVQMSRSLGIEDLIEFKPNASFNAIIEEMFKSKVYLHTMRGEHFGISIVEAMSAGLIPVVPDYGGCAEIVPEEYQYDGIDTAYATIQSALDASFSDRKRVSDIADLFSDNTFKMSMKKIVEQELGVRPSERLRHTATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKX3</accession>
    <name>K0IKX3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">purU</name>
        <name evidence="4" type="ordered locus">Ngar_c22670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22670"/>
    <dbReference type="EnsemblBacteria" id="AFU59197">
        <property type="protein sequence ID" value="AFU59197"/>
        <property type="gene ID" value="Ngar_c22670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2245"/>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_2"/>
    <dbReference type="OMA" id="HADHHTD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="291" mass="32735" checksum="7351FE255EAE3A0E" modified="2012-11-28" version="1">MAAARGKTIIEVTVVGPDRKGVVADITNFIFRNGGNIEKINQNVVRGLFGMQLEASFAEIDRKQLDDGLKQLSKKLSMEIKVHYQEPDRLQNVAIFVSKEPHCLAKLLEAKKKGEIKANIPVVIGSDTTLKPMADEVGIPFHAVAHIDQAEAENKILQLIDQYNIDLIVLARYMRILTPNFVWRYPNRIINIHPSLLPAFPGAYAYVQAYERGAKIVGCTAHFVTEDLDQGPIISQESFKVSKGDTLDTIKKKGQEMEAATLLEAVRLYLENKLEVYWGKVYVKDDERTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL28</accession>
    <name>K0IL28_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59282">
        <property type="protein sequence ID" value="AFU59282"/>
        <property type="gene ID" value="Ngar_c23570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23570"/>
    <dbReference type="HOGENOM" id="CLU_2392743_0_0_2"/>
    <dbReference type="OMA" id="CEDKYEA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2355-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10346" checksum="D4E5DBCCB2B15ACB" modified="2012-11-28" version="1">MKTVKFECDDHYEAGKLASLVSVQKDDTVYIDSVAAVVGNEIVIKLKDKSSHAVVLKDRENVARLQSLLLDVVKGKIKIRSSNFTGSVAEITLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL97</accession>
    <name>K0IL97_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59382">
        <property type="protein sequence ID" value="AFU59382"/>
        <property type="gene ID" value="Ngar_c24580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24580"/>
    <dbReference type="HOGENOM" id="CLU_1514546_0_0_2"/>
    <dbReference type="OMA" id="HFTINQE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2456-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="20523" checksum="0CE357D8609A3DAB" modified="2012-11-28" version="1">MPETASFQHYGISPWEIEVIFDTLRRSFEVEERQLQPDDPQYVSMIEIGFPAAYGEPFFQAFTMDSWFKIKGVIKDVKRRRGKKGVKTFIRFAGFGNESVDLVFPLLSKGDRQFEMGIEKIEYMVDIVPVQLKTIPPRAEEIWYSYDEASFRWSPAVAKSNCVNYFFKNGEWKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE3</accession>
    <name>K0ILE3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA polymerase subunit, Rpc34-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34380"/>
    <dbReference type="EnsemblBacteria" id="AFU60353">
        <property type="protein sequence ID" value="AFU60353"/>
        <property type="gene ID" value="Ngar_c34380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34380"/>
    <dbReference type="HOGENOM" id="CLU_142666_0_0_2"/>
    <dbReference type="OMA" id="CYEGGYY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3439-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="15506" checksum="BF4953EA807DA470" modified="2012-11-28" version="1">MKLNEAQIEDLTGKVFRTIISNGKDGILQSELWKELDLTSRDGSRVAIRLERRSLIRREKILESGRWTYKLFAVKLPVDTTSIEQAPCLTCPVEHMCSLDGSYSPTSCNLIEDWLINSLDSSNNNSNQKLPKPPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH9</accession>
    <name>K0ILH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60433">
        <property type="protein sequence ID" value="AFU60433"/>
        <property type="gene ID" value="Ngar_c35200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35200"/>
    <dbReference type="HOGENOM" id="CLU_2379513_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3521-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10485" checksum="B3591773B1798260" modified="2012-11-28" version="1">MPHLGIDIDQYILLTIYPAAAFFVIGYIAKKTHMHPGMSYFIQAITCITFAVAYIFVVPNGGAQGLAIVLGMFGMLLLFMARKQKIQRQEEQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ5</accession>
    <name>K0ILJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59517">
        <property type="protein sequence ID" value="AFU59517"/>
        <property type="gene ID" value="Ngar_c25950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2567"/>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2595-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20582" checksum="A36BA5CCB757FB2E" modified="2012-11-28" version="1">MRCKRYAVPIDSEFPKNHQVIGKHKHSDGEHYHFVWGPGRSTEAAENENVKAAYQARGEELVPLGVHGTMIAVDWDSCIADGSCIEACPVQVFQWYRTENDVPAAQMANATSAGTGSMVKEERKDYTDKSDPIREHDCIWCMACVSVCPPQAVKVDQSNLEFHEKAAGTFDESLAKGGQPPPHASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ8</accession>
    <name>K0ILJ8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26000"/>
    <dbReference type="EnsemblBacteria" id="AFU59522">
        <property type="protein sequence ID" value="AFU59522"/>
        <property type="gene ID" value="Ngar_c26000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26000"/>
    <dbReference type="HOGENOM" id="CLU_123922_5_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2600-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15947" checksum="E074D2E6C56173DC" modified="2012-11-28" version="1">MLKLEDKDVQFLNSMNVARLATIDNERNAPHVVPIIYAFDNKNSKFYLTTFKGTKKLRNMQQNKSISIVVDEYSKSAKKGIMFRGRAEVINPNTNEFRHAVKLLTDKLAYYKKNPISPDKSEVISIALISNSKWELPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM0</accession>
    <name>K0ILM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TM helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02160"/>
    <dbReference type="EnsemblBacteria" id="AFU57164">
        <property type="protein sequence ID" value="AFU57164"/>
        <property type="gene ID" value="Ngar_c02160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02160"/>
    <dbReference type="HOGENOM" id="CLU_878796_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-216-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="330" mass="34969" checksum="8FC4E62181B8D7FC" modified="2012-11-28" version="1">MPEMAGIGGEVIALLLITLQQVGTQSVTEPLTNSLNQFATSIAESGPRIIAALILLGIGLLVGRVIGWVVKKVAQKMNVDQHWNRTSIGESVSRSGWSLSKIISTAAKWFVYLFFISAAVNVLQFQQLSEAINAVWLWIPNVIAFIVVLGVGAIIADFVGRWMQRELPARGVVGGRALGLAATGILYAIVFAVAVAQLRIGETILNSVISALVWGVAAAVAIGVGVGLAYSLRETFPAMIRGSTQIQPTLKQGQRVTMDGKTGTIQEAGSFSIILKDDQGNTVVIPTKNIIDKEIVILSGPKPETSERMVEGMSAETAASPSYKTTGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP2</accession>
    <name>K0ILP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c26660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26660"/>
    <dbReference type="EnsemblBacteria" id="AFU59587">
        <property type="protein sequence ID" value="AFU59587"/>
        <property type="gene ID" value="Ngar_c26660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2641"/>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_2"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2666-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="4"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="8">
        <location>
            <begin position="341"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="453" mass="48959" checksum="FC060825E466C829" modified="2012-11-28" version="1">MEEFDLIVIGSGSGLDVANAAAESGLRVAVIEKGRMGGTCLNRGCIPSKLLIHSADVAEMIRSAGQFGINVDGFTVDFEKIINRTNSIVDSDSDRIRQAFSEIDNPKLFPHECRFVDKKTISVGGQTIKADKILIASGTRPAIPKIKGLEGSGFITSDEALRLKKQPRVLTIIGGGYIAAELAHFFGSLGTKINIIQRRDMLVPDEDEEVARKFTDLFSKKYNVHLGYNTQSVSKSNGTFAVVAKNSSGKKIEIESDQLLVATGRVPNSDTLDLEKTGVKIDSAGFIVVDEHLETSAKGIFALGDAVGRYLFKHAANHEAQYAFHNLMHENKKVAVDYTAMPHAIFSSPQIAGAGYTEQELRSKGIKYTKAIYPYIRTAMGEAIEDRDGFVKLLASSEGKILGCHIIGSHASILIHEVLVAMKLGAGIDAISRTVHIHPALSEVVARAAYAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ4</accession>
    <name>K0ILQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57229">
        <property type="protein sequence ID" value="AFU57229"/>
        <property type="gene ID" value="Ngar_c02810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02810"/>
    <dbReference type="HOGENOM" id="CLU_1529152_0_0_2"/>
    <dbReference type="OMA" id="GGISESH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-281-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="19626" checksum="AC8044A96F8912D7" modified="2012-11-28" version="1">MKLSALMIIAFFVTMALLTFSSSAKAFADPLQNAYRQRIGNYDVEMTTEPASPVAGSPANVLIRIAGVNGDDLVDVSITIRLAKDGAELQRTNPIIVPYGHYTYEYTFAEAGRYVLYVDLNDHSYSGEILTFTFFVNVAGPFDYVYYIVAPSTGVAVAAIAGTVIFMKRKRKASSRIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM04</accession>
    <name>K0IM04_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59852">
        <property type="protein sequence ID" value="AFU59852"/>
        <property type="gene ID" value="Ngar_c29340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29340"/>
    <dbReference type="HOGENOM" id="CLU_113976_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2934-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="18856" checksum="36A886CEDEC6FCE0" modified="2012-11-28" version="1">MEFKFQKRRGIGNVITTLIILIASVVLGAGVIFFGGSMFQTNTQSESIKISNVHSWVTSTGDATTAFVVQNTGSKAITINSISLRGVSVPTSNWYHTINSNQTTLQTELPVDHTEDNVTLGGTATTMTSGSISLDQGEAAIVYLNEAGNIEAIDAGNTYSLQVQAGQATAVQQVQVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM38</accession>
    <name>K0IM38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57534">
        <property type="protein sequence ID" value="AFU57534"/>
        <property type="gene ID" value="Ngar_c05910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05910"/>
    <dbReference type="HOGENOM" id="CLU_1154376_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-589-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="240" mass="28288" checksum="0DF0DE56CAB9540C" modified="2012-11-28" version="1">MIALTADTDWVPEKILNYFLDILDEYDATITIFATHEIDGRHHEIALHPNLETTYNKEKYQRHTSLETAEKLKKTFPQAIGMRSHGLNVCTDMLLFLPKIGLKYDSSYIMPFQDGIKPYIIYPGVLEIPIYWMDIEIMRFGKSLRFDSSVLREQQKSSTVYVYDFHPSHVFTNTCSLDFYYNTYRPNYHNVDFLEDQRNTKEFGAQDALVEMLEILDNSDLHLMSEIYEHFRNGQNSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD1</accession>
    <name>K0IMD1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57804">
        <property type="protein sequence ID" value="AFU57804"/>
        <property type="gene ID" value="Ngar_c08620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08620"/>
    <dbReference type="HOGENOM" id="CLU_3148092_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-860-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="48" mass="5440" checksum="A6ADB2A21EFFBD9D" modified="2012-11-28" version="1">MELNIRGKAVVSALHSHILDSQVSKLLLDWQSLVFSYRSRPFISGILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF6</accession>
    <name>K0IMF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60232">
        <property type="protein sequence ID" value="AFU60232"/>
        <property type="gene ID" value="Ngar_c33170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33170"/>
    <dbReference type="HOGENOM" id="CLU_1438158_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3317-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="188" mass="20245" checksum="416947AEFEA05B2E" modified="2012-11-28" version="1">MVGVIPISRINDIIDEASQNIEGYYQADLVSSDGLVIYSNHDKKAIMQNTLADLPVFDKIASSANPSESLIDSLTADNNNGGSIAASNNNAIYVAARERGFLDYRGNGWILIIAVPSEIAFSEVVQLRTNFIIVATAILSSSIITVIIFSKVFTQSLIKFKNAAAQIAKGNFDTSIKINSNDKIGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK4</accession>
    <name>K0IMK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34520"/>
    <dbReference type="EnsemblBacteria" id="AFU60367">
        <property type="protein sequence ID" value="AFU60367"/>
        <property type="gene ID" value="Ngar_c34520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34520"/>
    <dbReference type="HOGENOM" id="CLU_174522_2_0_2"/>
    <dbReference type="OMA" id="ENECIMI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3453-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="10077" checksum="902F186BC10ED459" modified="2012-11-28" version="1">MVDICDLDLIGSKLEQNGLVINLTKEYYQQQVIEQQEAQELLQKCDIANLVGDRIVKQALEMRLAKEISVKRIAGVPFLMIYKFQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML4</accession>
    <name>K0IML4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57994">
        <property type="protein sequence ID" value="AFU57994"/>
        <property type="gene ID" value="Ngar_c10520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10520"/>
    <dbReference type="HOGENOM" id="CLU_144084_1_0_2"/>
    <dbReference type="OMA" id="NIIGRIM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1050-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15500" checksum="C3C709455EFD31C1" modified="2012-11-28" version="1">MRKAVSLEFSELHEKVIIELDDSQSPKTVRAIINNLPIKVTVNRWGDELYTDETPVKAGEENAKSVVSLLDVAYWPEGSALCFFYGLTPISKQGKILPYSPVNIIGRIMSKPTANIQEFLKSVEKTHVSNKVPVTLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML5</accession>
    <name>K0IML5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, C-terminal subunit</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tktB</name>
        <name evidence="2" type="ordered locus">Ngar_c34780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34780"/>
    <dbReference type="EnsemblBacteria" id="AFU60392">
        <property type="protein sequence ID" value="AFU60392"/>
        <property type="gene ID" value="Ngar_c34780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3479"/>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_2"/>
    <dbReference type="OMA" id="VINTCDY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="323" mass="34511" checksum="555665E210522C7B" modified="2012-11-28" version="1">MLLSSEKKTADMRGAYGDTLVELGRDDPRIVCVGGDTTDSLKTKKFGDKYPERMFNVGIAEANLVSVAAGLSIAGKIAFASTYAAFIPGRCVDQIRNTICYPRLNVKLVVSHGGLTVGPDGASHQQIEDIASMRVIPNMRVIVPADAIAVKHLVKIIAHTPGPFYMRLARPSSEVIYADNAGSFEIGKGNVLEDGSDATIIACGLMVGRSLEAAKELKRKGVSCRVVDMFSIKPIDSELVAKCAKETGAIATVEEHNIVGGLGGAVSEVVAETYPVPVKRVGVRDTFGESARDEEIDMLLEQYGLTATEIAKAVLEARSRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM6</accession>
    <name>K0IMM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60417">
        <property type="protein sequence ID" value="AFU60417"/>
        <property type="gene ID" value="Ngar_c35040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35040"/>
    <dbReference type="HOGENOM" id="CLU_2662491_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3505-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8613" checksum="403E97A5FEA79ED8" modified="2012-11-28" version="1">MRDREKVMRDMHSKESAQKIIEAIRIHYNYCREHSVLKKTPAEQAGIKLDLSGNRVESLMRLAAKANNESAMLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU1</accession>
    <name>K0IMU1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ftsZ1</name>
        <name evidence="2" type="ordered locus">Ngar_c12740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12740"/>
    <dbReference type="EnsemblBacteria" id="AFU58214">
        <property type="protein sequence ID" value="AFU58214"/>
        <property type="gene ID" value="Ngar_c12740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12740"/>
    <dbReference type="HOGENOM" id="CLU_859474_0_0_2"/>
    <dbReference type="OMA" id="ECSIDCE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="1">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="336" mass="35927" checksum="FCD2789E748839C5" modified="2012-11-28" version="1">MSPVFVCGELGGSTMSDLLIKNPVLLVGIGGAGSKIATAASAALGCKCLLISNDKKDLIHNEKCTAVYVDSGEWVNPSSLKLRSFVEAHRKEMVAAMNGYSTVIIVSNLAGRAGTAMAPLVCRMAKELSTVISIAIMPFKFEKDRIFNSGTALRRVRETSDSTIVMDNDAFLDNNPELSQEECFSITNSAIVEVISSISSGTVRPALNILCTSRPSHSSESSLRDSVAMLYDAVPDAGSVKRAMVYVMGGDRVPIGDLNKIVGYVQGIFQEEGTTEVAMSSMAAADGVRVHLVASTPQKTRFDRYDPLGDIIPDVLDWDEPDSAPDIKLAMIPAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMW0</accession>
    <name>K0IMW0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13720"/>
    <dbReference type="EnsemblBacteria" id="AFU58309">
        <property type="protein sequence ID" value="AFU58309"/>
        <property type="gene ID" value="Ngar_c13720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1331"/>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_2"/>
    <dbReference type="OMA" id="SAETHHM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1370-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="56"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="471" mass="51733" checksum="E6B3853D2198CE29" modified="2012-11-28" version="1">MQNSCDVLITNASVVIPKVGIVDTNIMIEDGKIKALTNSASNNISASRKIDAQGKYVLPGAIDPHVHYGVYTPIDEAARTESRSAAVGGVTTMIRMLRLYESYRNVTKQLEASRSNHYIDYSIHASILRLEQVKDIPYLKELGINSLKIYMNLGADLNHIYMDLEPGTHGVKDGEVNMTDELLSAIVKEGSKVHSTILVHAENPAICSEQMRSGKEKGMGGLKAWSDCRPPSSEAESVAKVSEFGRKFGANLYFVHIGSTAALDAVLAEREKGRSNYYIETCPHYLTHTVDFGSVTGKVVPPIRSKSDLQSMWSALRNGIVDTIGTDHVANRLDMKMGKDGDVWSALAGFPGIATMLPVLLSYGVNQDRISIERVAEVTSYNTARIFGMYPKKGTIQPGSDADLAIVDLDLEKKVTPELLQSYSDYTIYDGHRLKGWPVMTIVRGRVVMENGQIDREVLGHGEFVPRPVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ6</accession>
    <name>K0IMZ6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0147 protein Ngar_c15550</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c15550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15550"/>
    <dbReference type="EnsemblBacteria" id="AFU58489">
        <property type="protein sequence ID" value="AFU58489"/>
        <property type="gene ID" value="Ngar_c15550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15550"/>
    <dbReference type="HOGENOM" id="CLU_165882_0_1_2"/>
    <dbReference type="OMA" id="RTIIWEV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1553-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="10811" checksum="A3A8BA299777DBEA" modified="2012-11-28" version="1">MTSSKKELKEKENQERLARAIETLDSITKNSDIQKSIRNMIKEVLLALKDEKGGSVSVRAANAISLLDNATQSPQMQSHIRTMLWQVVSTLESIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN57</accession>
    <name>K0IN57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58794">
        <property type="protein sequence ID" value="AFU58794"/>
        <property type="gene ID" value="Ngar_c18620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18620"/>
    <dbReference type="HOGENOM" id="CLU_1313076_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1860-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009272">
        <property type="entry name" value="DUF929"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06053">
        <property type="entry name" value="DUF929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="244" mass="27186" checksum="FB1BE20356AE876D" modified="2012-11-28" version="1">MQSAKSKAFMFFADRRAILAQIKIDRARNVDKINSENLVFVSSFIPKKALGKFMHVTDEPLKRQSGKSLVFFMGAGFCPFCAAERWTIVNALANFGRWEGLVETASAGHDEKYLNIPTFSFARAKYESDYVEFVGRETADRNFEPLQELDEKDFEILDMFNPDQIIPFLLIDGQFMQVGAGYSPQILEGMDHAKVKAELANPASPVGKAIKTEIDNITALICKSIGGKADVCNSENIKNLVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE2</accession>
    <name>K0INE2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative archaeal cell division protein CdvA with coiled-coil domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdvA</name>
        <name evidence="4" type="ordered locus">Ngar_c22920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59219">
        <property type="protein sequence ID" value="AFU59219"/>
        <property type="gene ID" value="Ngar_c22920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22920"/>
    <dbReference type="HOGENOM" id="CLU_082930_0_0_2"/>
    <dbReference type="OMA" id="MIAVKMS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041461">
        <property type="entry name" value="CdvA_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18822">
        <property type="entry name" value="CdvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdvA" evidence="3">
        <location>
            <begin position="84"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="271" mass="29903" checksum="0609AD3B0B9D6F10" modified="2012-11-28" version="1">MSEEKLGFVGKQVKDIYGTYIGRVVGIITEIDGEIETVGVDTGSGGLKQLPYEQLVIQGDYVFFIPKWRLDAQRLLRQKSLTLKRIKALQEIVAENDSMKEDAELVYIKYEKKLAELEGNEKQVNDALNARLAELDAEARNIKAVLFDAKLQFRSNEMKEETYQQIKVQTDELIEHINNERTEIGNVRAKMAANTLENLTAAATTEQAAASAKGEEAPAAEPSQPAADEISPVQQVTTATAGEEGEKPAMLSANGAEQQSETSWLSQVITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE3</accession>
    <name>K0INE3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22970"/>
    <dbReference type="EnsemblBacteria" id="AFU59224">
        <property type="protein sequence ID" value="AFU59224"/>
        <property type="gene ID" value="Ngar_c22970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2273"/>
    <dbReference type="HOGENOM" id="CLU_012856_4_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2295-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="706" mass="79914" checksum="479EBCB0282B1E68" modified="2012-11-28" version="1">MYGPGPFLYVLFLMIGWIMMIYTLNFYYLAYQSRNNIRHNKKMRQKTELPPNLPVVTIQLPLYNEKYVARRLIDAVCRMDYPKDKLHIQVLDDSDDDTIDLIKSIVDDYRFKGFDIVHMHRTDRSGYKAGALKAGMKHAKGEFIAIFDADFIPPASFLKRALGHFFTDKRLGLVQCKWGHVNENYSTLTEAQAVSLDLHFLIEQKAKSLSHLYMNFNGTAGIWRTACINDAGGWHTTTLVEDLDLSYRAQMKGWRCLFLEDLEVDAELPVQMNAAKRQQFRWAKGSIQVALKLLSDLMLHRRVPVDTKAQAFIQLTRHAVNPLFLAQFLIFPMLLAMSANSYAVGWVPLISVVMYIMMGPGGYLLVINQAWNGDPRMLREKARQFFFLMFFASGISVNNTVAVFDAVFGKRNEFLRTPKFGIVNKDDDWRNKEYVLPFTKTTLLEIFFAVYGCMAVFISLASGNAVYAPMIAVPTIGFIYVTYLSIVHSSFRKKKSDTRGTYAPAIAAGKHHNNNNLDSGATMAAASVITHTRVVNRQKVVLAGVLAFLIMGAGMAYYGYQTTLYHVNKAIGFVARAQTAQTPEQLAEYIKLAKIELMPVKGNNPVWLFPTARTDFGLIRENLDGILLRAESASAMVPHSEQYNMAMSDMHKSAERINLGLMEAIPYMYISISNLVMAGLWVAAIIAIFAAMRRARTRRVQIEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH0</accession>
    <name>K0INH0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="9" type="ordered locus">Ngar_c24350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24350"/>
    <dbReference type="EnsemblBacteria" id="AFU59359">
        <property type="protein sequence ID" value="AFU59359"/>
        <property type="gene ID" value="Ngar_c24350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2406"/>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_2"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="316" mass="34477" checksum="FF6AD3A5367903CB" modified="2012-11-28" version="1">MKTSLSKKDVLSIADLSTQEINSILTLAAKLKREQKRGKARPLLRGKTLGMIFQKPSTRTRVSFEVGTYQLGGDAVYLSASDIQLSRGETIQDTAKTLSLYLDCIMARVYDHKDVQTLAEYASIPVINGLSDEFHPCQILADLLTIQEHKKKMKGLSLAWLGDGDNVCNDLLLGCAKTGISMTAACPKGYEPLEEVVKLAKSEGIKTGADIAITEDPAAAAKDADIVVTDTFVSIGKEGERATREATFLPKYQVSSDIMKLAKKDAIFMHCLPAKRGMEVTADVIDSRSSVVWQEAENRLHVQKALLCLLMKVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ5</accession>
    <name>K0INJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c25620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59484">
        <property type="protein sequence ID" value="AFU59484"/>
        <property type="gene ID" value="Ngar_c25620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2539"/>
    <dbReference type="HOGENOM" id="CLU_191156_0_0_2"/>
    <dbReference type="OMA" id="WRFRESH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2561-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9476" checksum="EB96BAF3AE6A7862" modified="2012-11-28" version="1">MILIPVVAVFFLGINSAFAQEETGQYILHRVEIWALFYRLMVVAFVIGAVVMGSIFYVVWRFRESHPKNRGDITPARTGGGAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK5</accession>
    <name>K0INK5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable porphobilinogen deaminase</fullName>
            <shortName evidence="4">PBG</shortName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="4">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">hemC</name>
        <name evidence="7" type="ordered locus">Ngar_c26120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="4">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26120"/>
    <dbReference type="EnsemblBacteria" id="AFU59534">
        <property type="protein sequence ID" value="AFU59534"/>
        <property type="gene ID" value="Ngar_c26120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2584"/>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_2"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="5">
        <location>
            <begin position="5"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="6">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="4">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="315" mass="34387" checksum="7F27266ADAD2EE6A" modified="2012-11-28" version="1">MKKSIWVGTRGSRLAIAQTEIALAALRRAHPGVRFEVVTISTKGDVDKRPLFTMDEKGIFEKEVNEAVKKGEADFAVHSLKDIPSDLSEELVVACIPKRASPNDVLVNDKGQKLKELAPGSVIGTSSLRRAVQLTKYRPDLNVMPIRGNVETRVKKVISGEYGAVVLAEAGLTRIGMKDVIVERFSIRDFVPAPGQGAIAIVCRRDDKALIRMLGQIEDSRSRAEVLAERALIKKVEGGCRFPLGAVAVTNGDKITLYASVFSADGSRNIKVKKVGKASEPEKLGDKVAGMLVKQGAMEMAEGWRRAVDEWNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM2</accession>
    <name>K0INM2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rps27ae</name>
        <name evidence="8" type="ordered locus">Ngar_c26980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26980"/>
    <dbReference type="EnsemblBacteria" id="AFU59619">
        <property type="protein sequence ID" value="AFU59619"/>
        <property type="gene ID" value="Ngar_c26980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26980"/>
    <dbReference type="HOGENOM" id="CLU_179743_2_0_2"/>
    <dbReference type="OMA" id="GVFMAEH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7793" checksum="5C1A06F0D99A0A45" modified="2012-11-28" version="1">MADKKAPAKGEVAIYKFYKVSGDKVTRSRRDCPRCGKGTFMAEHKDRFTCGKCGFTEFTHKETAKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN7</accession>
    <name>K0INN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59694">
        <property type="protein sequence ID" value="AFU59694"/>
        <property type="gene ID" value="Ngar_c27730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27730"/>
    <dbReference type="HOGENOM" id="CLU_1064033_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2773-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030987">
        <property type="entry name" value="AbiV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18728">
        <property type="entry name" value="HEPN_AbiV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04498">
        <property type="entry name" value="AbiV_defense"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="261" mass="30936" checksum="E2FDF392F4FFF194" modified="2012-11-28" version="1">MKEIPYDRLPRGIKLCIHNANRLLQDAKLLRDNKKFSSALVCAIFAYEELGKAISLRDKWIKKENLTLKDWKQMLDHVKKSYHTNKFMQKKSGRQFDSDDNDFRRQLQKIEDDMLTFDATERSIFEKESNLYVNWTKAGWISPNDLDKIDGIANRRILEVSSAIEHFLDEEQTQEILSAPESEWIDKKKIELELMMLLFSFDRYDNSIKVETVVESDRITKIILTNSGRRLSGQEKQLIVSHFKEYQTMKKTKFFFIEHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU1</accession>
    <name>K0INU1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30480"/>
    <dbReference type="EnsemblBacteria" id="AFU59964">
        <property type="protein sequence ID" value="AFU59964"/>
        <property type="gene ID" value="Ngar_c30480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30480"/>
    <dbReference type="HOGENOM" id="CLU_1127116_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3048-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="246" mass="27230" checksum="24BDBB7FFC8C9CDD" modified="2012-11-28" version="1">MTRTFVGGIFATVAVLVVGVAIALPPFLQPPRGPPVMLAFSIINENNDVPYWCSEVSDILKKNNLDAVVFFSGIIAENHPQCVASFGENVDIGSSTYNYGNLTAIADYSEQLKEILDGKNAVDLAGDLNSKSFRAPYGSTDENIYSLLARSEILADFSYTDRYHKYHEGNFIWFRVTVYNASSISGAFIRDLQYDENDRPIQIDIDNTVPLSKVQEIVDALKDKRANFLNASELTGIELTVRGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV4</accession>
    <name>K0INV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31130"/>
    <dbReference type="EnsemblBacteria" id="AFU60029">
        <property type="protein sequence ID" value="AFU60029"/>
        <property type="gene ID" value="Ngar_c31130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31130"/>
    <dbReference type="HOGENOM" id="CLU_059557_0_0_2"/>
    <dbReference type="OMA" id="GGYHHHM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3113-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="159"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="32022" checksum="7D937E5F4436EDB6" modified="2012-11-28" version="1">MSLNVSDIDRSLDFYQRILGFKMVDRSSNERAFLSVERHSSHLVELWHAKAGRSDTRRAGLYHFAILLPERKYLADMFQHLSERGGEVRFDGFADHLVSESIYIRDPDDIGIEVYCDRPSSQWKWYEDRVRMATERLDTENLLRESTASGWKAMPAKTVIGHVHLHVRNLAKAMKFYREALGLNFTATYPSAYFFAAGKYHHHVATNIWLGTSIQPASPEHAGLNHFGIELPSKEEYEKTAGRLEQYKSEEMPQQHGQPESVFLRDMDGITIRLYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ2</accession>
    <name>K0INZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c33040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60219">
        <property type="protein sequence ID" value="AFU60219"/>
        <property type="gene ID" value="Ngar_c33040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33040"/>
    <dbReference type="HOGENOM" id="CLU_2534787_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3304-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="9695" checksum="974138F9BC70AA5F" modified="2012-11-28" version="1">MRKAAIALIVLVAGIIVNILVVTGIFMIPCVPATVDMKEEEEKEEEEEGPQPAFGNLTTCNEVRSPGFIILGVADVFAAVLIVSELVKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP41</accession>
    <name>K0IP41_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">uppS</name>
        <name evidence="4" type="ordered locus">Ngar_c35510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35510"/>
    <dbReference type="EnsemblBacteria" id="AFU60464">
        <property type="protein sequence ID" value="AFU60464"/>
        <property type="gene ID" value="Ngar_c35510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3555"/>
    <dbReference type="HOGENOM" id="CLU_038505_2_0_2"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="31843" checksum="E970322CC1E9B293" modified="2012-11-28" version="1">MGLQTDIDKGGRALAHTFLQLSGIYSFYEKRLESEILKSPLPNHVAIVLDGNRRWARFHLLDPAIGHNHGADKAEELLNWIHDIGVKITTLYILSTENLERKDEELENIYKLLEIKLKKLYNDQRVHNRRMKIKAIGDTKLLPRKLQEILTKLEESTAEYDSMFLNIAIAYGGQKELVEAVRKIAQMAKDGKIKVDEINEKTIESCLYTSHLPQPSPDLILRTSGEKRLSGFLIWQSAYSELMFMDVFWPEFRKIDLMRAIRTYQRRVRRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6Z9</accession>
    <name>K0I6Z9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c00910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57041">
        <property type="protein sequence ID" value="AFU57041"/>
        <property type="gene ID" value="Ngar_c00910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00910"/>
    <dbReference type="HOGENOM" id="CLU_184933_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-91-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="9054" checksum="72C348BF54711BFB" modified="2012-11-28" version="1">MGIGLLRREKNECEDCHERFSSYDELIGHTRDVHKRHIIKCRFCGKQFIHEKDRLHHEREEREKKVDARRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0I839</accession>
    <name>K0I839_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methionine synthase</fullName>
            <ecNumber evidence="4">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metH1</name>
        <name evidence="4" type="ordered locus">Ngar_c04920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04920"/>
    <dbReference type="EnsemblBacteria" id="AFU57436">
        <property type="protein sequence ID" value="AFU57436"/>
        <property type="gene ID" value="Ngar_c04920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.471"/>
    <dbReference type="HOGENOM" id="CLU_004914_3_0_2"/>
    <dbReference type="OMA" id="AQEDYKM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hcy-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="315" mass="34479" checksum="2B08B32ACF670103" modified="2012-11-28" version="1">MSPESFLEAAKRQVLLFDGAMGTEIQRLNPKPEDFPDGKDGFNDGLILSRPEWIKQIHRSYLKAGADCIETNTFGSNKLKLDEYGYGDKTVEFNKKAAELAREVCNEFKDRPRYVIGSMGPTGYLPSSNDPDLGQKPLDEIRDAFMLQAEGLILGGVDALLIETSQDILEVKLAIEACHMAMEKVGKKVPIIANITLDQYGKMLLGTSVQAAYTTVSDMKIDAFGLNCSTGPAEMAPSVRWLSEQGLPILVMPNAGMPHNEGGRAVYKMGPKEISEALAEFVSKYDHVRMVGGCCGTNPQHIAELRKALDSSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I875</accession>
    <name>K0I875_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57471">
        <property type="protein sequence ID" value="AFU57471"/>
        <property type="gene ID" value="Ngar_c05280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05280"/>
    <dbReference type="HOGENOM" id="CLU_2857205_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-526-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7309" checksum="FFD829F6D4E4DAC4" modified="2012-11-28" version="1">MLNKKLSNVRMLKLSSWCTAILDGKQVRVRVRHLGRGKFQVIEDESGTNNQKIIDASDIIHCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Q8</accession>
    <name>K0I8Q8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07180"/>
    <dbReference type="EnsemblBacteria" id="AFU57661">
        <property type="protein sequence ID" value="AFU57661"/>
        <property type="gene ID" value="Ngar_c07180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07180"/>
    <dbReference type="HOGENOM" id="CLU_711005_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-716-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="37"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="388" mass="42481" checksum="ED987F2A2B688FB7" modified="2012-11-28" version="1">MASEDLQIRINGVLPDIDAGATAANTSLSMFYQGFHLLVDAGSGVQESIKKNAGMPDAVLITNAKMQHISDLPSLVKEKNAKVYCTAECGQQIAKELPSIGSPSSSFVHVSPGTPFEVGPFSVVPIAADNAGDRPGMPGSVIYVIRAGSRKVVAGWDFLKLPGADERILWNPDLLVLGTETYNEHPSTGMISVSEAYNIVRRWNAKLCYVLHYSGEKDREDAKNQWHRGPARPLSPDELQKAIDDHLLVSGAEGKYVIKVAREGMTWSPAEETVEEEGPTGKRIEVDALDRHTFAIEKMDDGKVALTIEDSINRLTAEFVNPKSGENSLHGNAIKNMMMKGPELELTVSGNTVRIDITKGKKTLFAGDMQVSERDSKRIIRYLHENFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I950</accession>
    <name>K0I950_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57846">
        <property type="protein sequence ID" value="AFU57846"/>
        <property type="gene ID" value="Ngar_c09040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09040"/>
    <dbReference type="HOGENOM" id="CLU_055261_1_6_2"/>
    <dbReference type="OMA" id="FACSWIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-902-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7866" checksum="50638FB251483005" modified="2012-11-28" version="1">MPHIRHRGEKKQKRRYKRRRWVVERTNSWHNRFRKLLVRYEKKSENYLGLVQLWPAASLYTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I969</accession>
    <name>K0I969_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57871">
        <property type="protein sequence ID" value="AFU57871"/>
        <property type="gene ID" value="Ngar_c09290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09290"/>
    <dbReference type="HOGENOM" id="CLU_2613749_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-927-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9031" checksum="F9E5E799FB7F46FE" modified="2012-11-28" version="1">MEAYNKIVKNEFLAVENIPDREDGKARYAMFVNAYNNMDREHGGIIGGLTPQERWLQLLNTPTRNKNQLKKSVTYVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9N3</accession>
    <name>K0I9N3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10890"/>
    <dbReference type="EnsemblBacteria" id="AFU58031">
        <property type="protein sequence ID" value="AFU58031"/>
        <property type="gene ID" value="Ngar_c10890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10890"/>
    <dbReference type="HOGENOM" id="CLU_170065_0_0_2"/>
    <dbReference type="OMA" id="WIIDDIE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1087-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12587" checksum="D32794620819F8C3" modified="2012-11-28" version="1">MPKVSSHDIRKIIFDNFNDADTRFSNDEILGYLNQIDKYKQLDDVLDFEDVLLEMEKSGMLRPIAQNFNTRYYRLWNTLELATCKACSSSTYFAPNEEGKACPQCGANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9Q1</accession>
    <name>K0I9Q1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="3">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">panB</name>
        <name evidence="7" type="ordered locus">Ngar_c11040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3 6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11040"/>
    <dbReference type="EnsemblBacteria" id="AFU58046">
        <property type="protein sequence ID" value="AFU58046"/>
        <property type="gene ID" value="Ngar_c11040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1046"/>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_2"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="3 5">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5 6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="29494" checksum="6E5707F8EC229DF8" modified="2012-11-28" version="1">MSVNDIVAMKGMEKISVLTAYDYSTSLICDRAGVDVLLVGDSAGMVVLGYPNTVPVGMPEMTMFCGAVARGAKRAMIVGDMPFGSYQPSASVAVENAVQLIKAGCDAVKLEGGSEIIGTIKAIVDAGIPVMGHIGLKPQTSSLWEGYRLQGRTKVSAMKLVQDAKALEKAGVFSIVLEMVASEVADEITKSVTVPTIGIGSGVGCDGQVLVLHDMLGIYEDIKPKFVKRYSELSKSIFDAVASYTREVKEGKFPEGSNTFHMSPEELDRFRKARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA71</accession>
    <name>K0IA71_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58211">
        <property type="protein sequence ID" value="AFU58211"/>
        <property type="gene ID" value="Ngar_c12710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12710"/>
    <dbReference type="HOGENOM" id="CLU_1965632_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1269-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14064" checksum="CB703F129EBCD0E1" modified="2012-11-28" version="1">MMPDSIDAILQLPQRKLVVAQNDVYLDKQVKNEIFILMVEESKGSAGGRAAGSGHRRVERIYGFACDGGICTKFFESGEQDKVDQFDIPYSAVAMDIRLSDGRPYVVQGIVDPDFVASYRSVISNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAA0</accession>
    <name>K0IAA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58246">
        <property type="protein sequence ID" value="AFU58246"/>
        <property type="gene ID" value="Ngar_c13080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13080"/>
    <dbReference type="HOGENOM" id="CLU_1021636_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1306-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="28381" checksum="2C9DE097866498D5" modified="2012-11-28" version="1">MNLRRKGAIVAIASMIAILYVLSPVPYLLSADRPSSILPVFQIVIPALAFPLIALLVFAVPKRVIDREPVSEHAMHDMAEYRFKRKSLVSGAAGGLIAASVLVGLIFAGDTAVGLPSGTFYSIIGVAMGGLEMPASVYFGIALHLLTGTLVGATFGYVTAVTGPFNITSIAKGAGVGVLAGFVTFSLLFIPLTRFEVEPSLLRILASIYPPGTSDIALQNKALDIMSSVLAGAILLHMVYGAIMGTITALILLVRHKKQEKVSGSSSASIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAI9</accession>
    <name>K0IAI9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58331">
        <property type="protein sequence ID" value="AFU58331"/>
        <property type="gene ID" value="Ngar_c13940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13940"/>
    <dbReference type="HOGENOM" id="CLU_173770_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1392-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15469" checksum="8B9C5DBCA4A76D09" modified="2012-11-28" version="1">MSDGPTILWEQLKGKRVKTNDGKDLGEIKEVTQDYIRLEKGVVDKDKFWIPKYVADAYDGKVLWLLVSSDDIAKGYSYTTQPAREQYMREFETFRSTPYGQKATYLPDFEQNIRVTEERAGAQGAGYKNIRDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB43</accession>
    <name>K0IB43_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nfo</name>
        <name evidence="9" type="ordered locus">Ngar_c16180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16180"/>
    <dbReference type="EnsemblBacteria" id="AFU58551">
        <property type="protein sequence ID" value="AFU58551"/>
        <property type="gene ID" value="Ngar_c16180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1586"/>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_2"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="284" mass="30700" checksum="9055F3978FC1DA4E" modified="2012-11-28" version="1">MGIRVGFHVSIAGGISNSVDNAKKLGCTAFQIFSRNPRGWAAKPLAPDDVQLFKSKLATSGIEKNSVIVHMPYLPNLSGPDGEFYKKSVETLTGEIQRCSALGIPYLVIHLGSHMGKGQASGLSQLVKAIESARVKSDGGAPMVLLENNAGQKNCIGGNFEELRTILDKLDDPKKFGVCIDTCHLFVSGYDLRTKAEVDKTLEKFDNVVGLKELKFIHLNDSKGPLGSNLDRHEHIGLGSIGSEGLAAFLNHRAIRGLPVIMETPIDEKRGDEQNLQVVLGMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBT8</accession>
    <name>K0IBT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57020">
        <property type="protein sequence ID" value="AFU57020"/>
        <property type="gene ID" value="Ngar_c00700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00700"/>
    <dbReference type="HOGENOM" id="CLU_2079492_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-70-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13738" checksum="4A537DA57079EF41" modified="2012-11-28" version="1">MDDCLDDTIEFLDRKILQLDREIKKMATTDDRYARHLMTIPGISYYAALLISAEIADINRFSDYEHLCSYAKLIPGTYQSGDKQYQRPDMKGNDMLNWIMIQCTHVHVQYCDSIRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICH6</accession>
    <name>K0ICH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59081">
        <property type="protein sequence ID" value="AFU59081"/>
        <property type="gene ID" value="Ngar_c21510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21510"/>
    <dbReference type="HOGENOM" id="CLU_2679065_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2149-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8718" checksum="46116D7324F63633" modified="2012-11-28" version="1">MLGNETSKLIFKTFKLVYKMDEQSIISNPIQFEDRLKRLLGSQQAKIISELLVRQIEKTIKTMMAVRGEDQKWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICQ2</accession>
    <name>K0ICQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59146">
        <property type="protein sequence ID" value="AFU59146"/>
        <property type="gene ID" value="Ngar_c22160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22160"/>
    <dbReference type="HOGENOM" id="CLU_2911662_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2214-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6396" checksum="E747C9E23AD61378" modified="2012-11-28" version="1">MEPIMLGIISFDMIVGMLLGMATSPLMMKGIKAIRQKRKLDRMLHEIAEIRNKGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE41</accession>
    <name>K0IE41_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c10980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10980"/>
    <dbReference type="EnsemblBacteria" id="AFU58040">
        <property type="protein sequence ID" value="AFU58040"/>
        <property type="gene ID" value="Ngar_c10980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10980"/>
    <dbReference type="HOGENOM" id="CLU_073526_1_0_2"/>
    <dbReference type="OMA" id="IREFHRH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1096-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040825">
        <property type="entry name" value="FKBP26_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18046">
        <property type="entry name" value="FKBP26_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="27816" checksum="F11A80933E0F5896" modified="2012-11-28" version="1">MEKGSLVLVDYTARVKDTNEVFETTREEDAKKTAELYDPTRKYEPRLVSVGESWVLKGLDEALAKANVGDKLSVEVTPDKGFGERDPNKVRMIPQRKLGDKADEVGVGDVIEVDDRTGIVRYVGSGRIQVDFNHRFAGKTLLYDVNIMKKLESDSEKVSALVRRRTGLEDSKVKINLSAPNLDIELPEEAFLAEGLQVIKRAIANDIFKFVPSVKNIKFIESYYSAPAPAEQKKEQPKAEATTTPEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE42</accession>
    <name>K0IE42_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-octaprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
            <ecNumber evidence="2">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiD</name>
        <name evidence="2" type="ordered locus">Ngar_c27050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27050"/>
    <dbReference type="EnsemblBacteria" id="AFU59626">
        <property type="protein sequence ID" value="AFU59626"/>
        <property type="gene ID" value="Ngar_c27050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27050"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2682"/>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_2"/>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="484" mass="54160" checksum="163424919FEE9382" modified="2012-11-28" version="1">MPFESLGEYIEALEQAGQLKRVKAKVSPNLEIAEIMRRLMYSDGPAVLFENVEGSSMQVLGNAFGNMKRLEIALETQDFTEIGRRITELTKMKMPSGMLNKLKMLPKLSEISEYGPKYVDNGPVNEVVETDNKASLNSMPVLKSFAGDAGRFITFGLTVTKHPETEIRNFGVYRIQIIDDRHAIMHWQTHKRGAQHYKMMKEQGKKIEVAIVVGADPATVFSAVAPVPEGMDKYLFSGITRKKGVKLVKCRTVDLDVPANAEIVLEGYVDPNDIRMEGPFGDHTGYYTPAEPFPTFTLTGIMRRSRPIYLTTVVGKPILEDAFIGKVIERSFLPLIQMFHPEVVDFAMPAAGWFQGLAIMSIKKQYPGQAKKVMMGLWGMGQLALTKMFIVVDSDINVHDMNDVIWAVTTRADPARDTIIINNTPTDTLDPASPLVNLGSKLGIDATTKWKEEGYMREIQELAVVDEETKALVDRKWPEYFNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE92</accession>
    <name>K0IE92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57123">
        <property type="protein sequence ID" value="AFU57123"/>
        <property type="gene ID" value="Ngar_c01740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01740"/>
    <dbReference type="HOGENOM" id="CLU_1536709_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-174-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="20238" checksum="BE9622102A002466" modified="2012-11-28" version="1">MRFPLRDIIIDEQKLMLSRELNTMLRSYLKDMKVNIRSGFNIKSSSGGKSVAELKKSKAVKETLEQTRQQPLEKTSSKKIDGTINVRWEYADLGNEKEPIYFVPPNTIYCNTSSDLYRFAVAKNRYYGPTWIRVLPYLSRIAVIMSNGSSLRPEEFNLKVDQATRYFLKQKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE98</accession>
    <name>K0IE98_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit M</fullName>
            <ecNumber evidence="6">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM</name>
        <name evidence="6" type="ordered locus">Ngar_c11590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11590"/>
    <dbReference type="EnsemblBacteria" id="AFU58100">
        <property type="protein sequence ID" value="AFU58100"/>
        <property type="gene ID" value="Ngar_c11590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1099"/>
    <dbReference type="HOGENOM" id="CLU_007100_4_2_2"/>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="183"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="585" mass="63013" checksum="ED83F20D39C139C7" modified="2012-11-28" version="1">MAESYFLLAATFIPLLLAPVAYGIGRKAGVNAATWFSFGILAVSTALLLIPAIGIYNGQQQTYVESYVWGQFGNFGLRLDGLSLPFALIIYILCTVLALYSKPYMVHKVSEDLPEHKAGHNGDSNGPVASAGNDHSSHGSSPNISSSQQLTVLETDQRVKNQIALYFSLYLAFSMGMLGTVLATNLIEFYVFFELMLVPSFFLVAFYGYGARRRIALMFFFWTHVGAVVLLLGLLAMGFFAGGFDFDTIRANAGNIPAQWLPLIVFALVIGLGVKLAAFLVHIWLPYAHAEAPTPISALLSPAMIGIGAYGLLRLWMELLGGTGAYEQYSLYINMWGLATMIYGGAMALMQDDIKKVLAYSSISQMGYILFGLGAESVLGITGGTLMYVTHGLGKAILFMMAGSIILQTGTRSMTKLGGLAGKMPYTAVLAMIGALTIIGIPPTSGFMGEWILFNGMLQTAATDMDPLRTTMFGLGILATVLSSAYILWMFKRIFFGKIPEELAHVKDSNRYITVTMAVFAAMTLIIGVYPDLFLAPIDDYINGMFEGNSEVLPVPVHIEESENSGESVVVAPPEAATAGGEGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEC1</accession>
    <name>K0IEC1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF608 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11850"/>
    <dbReference type="EnsemblBacteria" id="AFU58125">
        <property type="protein sequence ID" value="AFU58125"/>
        <property type="gene ID" value="Ngar_c11850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11850"/>
    <dbReference type="HOGENOM" id="CLU_591361_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1183-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF608" evidence="2">
        <location>
            <begin position="217"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="524" mass="59803" checksum="F43717BD2CA3F09A" modified="2012-11-28" version="1">MIDPSSCELQQKDWTRFFIEADRFLEKTAEYVHRGVNPGGYYQAIWTRDAAFILKDQFLTGDTYNVLRSLHFIWAHQIGLNDEKIIYGRGSPELGFSVQYADKKTKEKFSGALPSTIYYNQGFSEVYARNPDIDSTALMISTTSWILDVYLKAGLYSYYESLPEWSSASSPPDPSSPPKSAARPLSSADYRRRQQDSHSDALYKTGVPPLKVISKPVELIEFIVPRMLAAVEYLASRDIDNDGLLEQGYNEDWMDTALRAGKIVYSQASWILALSDLSSLLYEIGRKTTAENLTEMAERTVSAVEEKLWSEKDGAYIDLKYNGAKNDKSDIDSNRERMLTQDISLYLVSITENTLNDILSVRFKSENNGSDASHRSPAIGRRFDERKERQDRIQPRVPRKIIEHRAASTLEAIKDRIWMDSAWPLVTEKELDRTGPWLLDPNQYHNHTFWPWITGIEILARSRFHRHGECNELLSALTRASHPQTLAYYEWVNPITGQGNGAFPFRTGISTIRVALTDILLSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF73</accession>
    <name>K0IF73_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Ngar_c31000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31000"/>
    <dbReference type="EnsemblBacteria" id="AFU60016">
        <property type="protein sequence ID" value="AFU60016"/>
        <property type="gene ID" value="Ngar_c31000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31000"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3074"/>
    <dbReference type="HOGENOM" id="CLU_037123_1_1_2"/>
    <dbReference type="OMA" id="IELHITF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3100-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="318"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="395" mass="43160" checksum="1B8D455CA03BB499" modified="2012-11-28" version="1">MARVRGIPVRLHFTMVIAFLLIAWTLAGGLMQVYVPGLTAAQYWLMGAAGAVVLFFSVFLHELMHSIVAMRYGIKVRQITLFIFGGVSEITEETRDFRKEFNIAIAGPVTSFAVASVLATIWWPISSFITDASPLALPKQMAEGVLLYGAIVNALVGGFNLIPAFPLDGGRVLRAALIRQKRSYDDATRIAARVGVAISYGFMGLGFFIMLAGSFISGIWLLLIGWFLNSGAQSYLVQHELSSALSGVRLRDIMNTRVITVREDIAVDQLLRDYFGAYMKSAFPVVDASGRLLGMVMLKSVTGVADERRQHIRAGDIMIPAGDLAVMAPDRRADEALQQMTRTRVGKVFVCDAGGRLLGLVSKTDIMNVASEREEYRKELGAQRRPAADSTTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF99</accession>
    <name>K0IF99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60046">
        <property type="protein sequence ID" value="AFU60046"/>
        <property type="gene ID" value="Ngar_c31300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31300"/>
    <dbReference type="HOGENOM" id="CLU_2857217_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3130-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7058" checksum="6944B9ED60181227" modified="2012-11-28" version="1">MPAVNWVLVGVIMMAASVATLSSAFVVSRLSQRRMMIIMIQPSVFAAQKPTEKSIVIVLLIFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFF5</accession>
    <name>K0IFF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57563">
        <property type="protein sequence ID" value="AFU57563"/>
        <property type="gene ID" value="Ngar_c06200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06200"/>
    <dbReference type="HOGENOM" id="CLU_2379502_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-618-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="11169" checksum="17E2DCB257F20557" modified="2012-11-28" version="1">MSSSYVRIGVNTAGFERYTPLQQAIELLQRLEKRSSNAEKLARELGTEENFISHFIRFLHDMQWIRSDNRELWCITEKGGVWLHNIQDMLEDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFM6</accession>
    <name>K0IFM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphogluconate dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57633">
        <property type="protein sequence ID" value="AFU57633"/>
        <property type="gene ID" value="Ngar_c06900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06900"/>
    <dbReference type="HOGENOM" id="CLU_2613748_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-688-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8898" checksum="70B92B2AA4B116FB" modified="2012-11-28" version="1">MERGFREQVLAKTESYIEDTGEVNWLVLDAINKEVPIPVISQSIMELLKSRMNESDAYKSIALMRHGFGGHPFGKMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFY7</accession>
    <name>K0IFY7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6438 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17670"/>
    <dbReference type="EnsemblBacteria" id="AFU58700">
        <property type="protein sequence ID" value="AFU58700"/>
        <property type="gene ID" value="Ngar_c17670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17670"/>
    <dbReference type="HOGENOM" id="CLU_141428_0_0_2"/>
    <dbReference type="OMA" id="YAYLNIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1765-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045497">
        <property type="entry name" value="DUF6438"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20033">
        <property type="entry name" value="DUF6438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6438" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="14069" checksum="F8A9EE4CFFB2B498" modified="2012-11-28" version="1">MCPGACPDYSVFVYGDGRIVYEGRRYVAVKGRREGRILGTRVKQLLDQFYKANYFSLKDRYDAIATDGAITKTSIFADGKTKEVVNCYPSQAPEELYQLEKMIDEISQSGRWVRDQAGQPVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFZ7</accession>
    <name>K0IFZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c34110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60326">
        <property type="protein sequence ID" value="AFU60326"/>
        <property type="gene ID" value="Ngar_c34110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34110"/>
    <dbReference type="HOGENOM" id="CLU_791354_0_0_2"/>
    <dbReference type="OMA" id="DWIAIDI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3412-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="350" mass="40850" checksum="27DDC13A616AF8E8" modified="2012-11-28" version="1">MNSEFSLPEIITAIKSVKQQFQPTPELLQMMETFRQIVNDCIRIGLDNDISTMKKLCNLAYKQLASYEIMSYYKLCAISHAAGILANRKKSIKRNLRPRRPYATKPLLVSCYGFKIIDGILKVPLGDRQYYDILLNDYIRRVLSDPLLKIRSFTLTIDSVSICCSKEVAQVECTDIEGVDRNLRNLTIGNLENIVQYDLSKTIDIADNTRSIIRSFKRNDIRVRRKLYGKYGKRRKNRINQLLHHVSKVVVQSAKYNKSAITFEDIRHIRWLYQRGNYQGHTYRGRMNSWSFAEIKRLITYKAAWEGVPVIQLSKNETRGTSQLCPRCGKKIAQVDRRKTRQLWCDHCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGD0</accession>
    <name>K0IGD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family, includes UDP-galactose 4-epimerase-like proteins</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09410"/>
    <dbReference type="EnsemblBacteria" id="AFU57883">
        <property type="protein sequence ID" value="AFU57883"/>
        <property type="gene ID" value="Ngar_c09410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09410"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.898"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-939-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="5"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="313" mass="34493" checksum="EBD7B59926131450" modified="2012-11-28" version="1">MQSILVTGGAGFIGHHLVRRLLQQDYRVVIIDNLSSAKTENIPRHQNAVFYKEDVRNMETISDIVKRERIDACIHLAAITSVTESLVFSNEVTDVNVNGTASVLEACTNAGVGSFVFASSAAVYGEAKILPVPEDKELRPISPYGESKVAGEKLVESYQKSGKIPHAISLRFFNVYGEGQNPRYAGVITKFTERLSKGLPPVIYGDGMQTRDFISINDVVDAIMLAIGSGTFGVFNIGTGKAITINELAKEMMRMFGLDLRPEHQKANHGEILHSCADIKRSSTALGFVARRTLEVELRNIIETNLYQQIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGD8</accession>
    <name>K0IGD8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58865">
        <property type="protein sequence ID" value="AFU58865"/>
        <property type="gene ID" value="Ngar_c19330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19330"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1931-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="21103" checksum="E13BC12A61BD54DA" modified="2012-11-28" version="1">MTSGQYFNKGVKALDSPHVGHVVRETDDKIVVFGGGDDRYDIPKSEIKFTSGNVLIDLPMYEIAKRYKVSREEPLPTGKATKDPWTRPENVDLATYEREYPKSLFNKGVRTNNEDHVGHVVKETKDKIVVFGHYDYRFDIPKSEIIAVGRNVIVKPDFPEILKYRVDRNAPLPTGEPIDKLAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGG1</accession>
    <name>K0IGG1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60481">
        <property type="protein sequence ID" value="AFU60481"/>
        <property type="gene ID" value="Ngar_c35680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35680"/>
    <dbReference type="HOGENOM" id="CLU_999718_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3569-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="278" mass="30138" checksum="6D23F1E4109A632F" modified="2012-11-28" version="1">MMEKYFLRVTVLAGFFFMLILSLPAVAVAQLYFPPADTKAEKLSPKRSLNINFLTIDEILKAQKKLGSDIYVQISNTSQGQPSEVQAVVLGNTMYVTWIGNGTTVFLAKVQGKGAVLNSPVVLSPKAISLNNTVNASNLQISVEHNLVAITWLAVKADTGLSTVDGSLSRDGVNFHSFQISTNVYNASAPFQPNAHFVIYIVHDDPNDDKNPCGPPRPPLDRYALLDNNTSITTVTIPDLLDSSSNNATTTSNSGQQISEAISLPGRPPDIVCLYRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGG8</accession>
    <name>K0IGG8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate update regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phoU2</name>
        <name evidence="2" type="ordered locus">Ngar_c35730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35730"/>
    <dbReference type="EnsemblBacteria" id="AFU60486">
        <property type="protein sequence ID" value="AFU60486"/>
        <property type="gene ID" value="Ngar_c35730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35730"/>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="MENEVEP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="358" mass="39972" checksum="B39A504B7DE4E849" modified="2012-11-28" version="1">MRTGSDYKEVRKVQFTGRSTYVLSLPKKWIEEMHLHAGDQVTIARELDNSLSVVPVALGSSDSLSEATAIILPSEGSSTLKRKVVSMYLAGYNIIHLKLKMGRINPALRDAVREVVRRNLVGTEMIADASDNITLQVLLSLPELSVNTAIRRMYLIASSMHKDAMSALSELNYELAKEVIKSDDEVDRFSLYVLRNLVMATQNGRVLREVGLKNPSDCLSYRVAVKSIERVADHACGIADKAARLKDRIPRDSLQKIERMSHLALMVLGDSVEALLRRDYHLADKTVDNAENIHKLEDYTIAAVEKDRVRDLASIKLALEDIRRTAEYASDIAEAAMNETIDEVIEKHNSSPSSRGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGP5</accession>
    <name>K0IGP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59000">
        <property type="protein sequence ID" value="AFU59000"/>
        <property type="gene ID" value="Ngar_c20690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20690"/>
    <dbReference type="HOGENOM" id="CLU_178999_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2067-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="11377" checksum="C0B2BF0BF7594AB0" modified="2012-11-28" version="1">MALFGIFATHSPESCPLNNKQSRDTFVQIDEKLKAATAKHNITNIVGFYMSVLEHQWVIIVEANNAHDIETMCIEAGISAFNTVKIVPLNNFDVVMKRIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW2</accession>
    <name>K0IGW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome c biogenesis protein, transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58083">
        <property type="protein sequence ID" value="AFU58083"/>
        <property type="gene ID" value="Ngar_c11420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11420"/>
    <dbReference type="HOGENOM" id="CLU_044955_0_0_2"/>
    <dbReference type="OMA" id="HANIRRA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1140-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="333" mass="37956" checksum="0788DD7182AAD3EB" modified="2012-11-28" version="1">MDVIPATPAPEFRDITGWANSDPLSIKGLKGKVVVLDCWTYTCIFCLRTIPVMRRLQQKYGKYSLQVVQAHSAEYHFATDHANIRRALQRYNVIDIPNAFDTNNKTWEAYGNMYWPKHVIIDQNGFIRYEHAGYGGMADFEDAIIELLEEAGKKPAEERDQDDPKDEILDTYGMHFYGMAPETCVGYSRLRRFGNNQTLKPDAANIVVDPGSHDVNVVYLRGKWIWQREGVQFSPGGKEQNPAVIMNYNAGKRVHGIMGTSDGKPGRIEIRLDGNHLTKDQLGRDARLEGSVSIADIQWPFIHNLVKTDKPEMHEIEIIPRSDNFVFYTFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX4</accession>
    <name>K0IGX4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59110">
        <property type="protein sequence ID" value="AFU59110"/>
        <property type="gene ID" value="Ngar_c21800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21800"/>
    <dbReference type="HOGENOM" id="CLU_2177960_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2178-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12881" checksum="6FEC3898A5C1DDF4" modified="2012-11-28" version="1">MSIQKEDRLDIIYYYYNFEYLDKSACQEAYIVLLFDDVNNLDALVADYINEGLKRGQFCVYASVYLRDGRHHMEKLSILIDDYKENVRKENLLVVDLAPLCSDWRRGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHB7</accession>
    <name>K0IHB7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate/guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23950"/>
    <dbReference type="EnsemblBacteria" id="AFU59320">
        <property type="protein sequence ID" value="AFU59320"/>
        <property type="gene ID" value="Ngar_c23950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2366"/>
    <dbReference type="HOGENOM" id="CLU_057456_1_0_2"/>
    <dbReference type="OMA" id="CAKSMIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2393-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="30719" checksum="5A5E3C43D429865E" modified="2012-11-28" version="1">MAEAKKEQGEEQDKTNKTLFDMMMSSSGASAQEPKTVDSETLVSQTQDRLWKALKRRYQYDVSLELGQKYLLNHVSSKIPLVIMYADLVGSTNMSMTLPADKLTTIIRAFTYEMSQVVDSHEGYVLKYVGDAVIAFFPASYNKLLACDRAVQCAKSMMAVVKNGINPILNQYDYPELNVKIGMDEGENVIVQYGHDRSSLIDILGYCMNIAAKITLLTGPNRISIGEDVYKMLHPSIKAKFKEMKLNPDEWKYTDRQTGKLYRVYTTQDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF9</accession>
    <name>K0IHF9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">alaS</name>
        <name evidence="13" type="ordered locus">Ngar_c24410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24410"/>
    <dbReference type="EnsemblBacteria" id="AFU59365">
        <property type="protein sequence ID" value="AFU59365"/>
        <property type="gene ID" value="Ngar_c24410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24410"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2414"/>
    <dbReference type="HOGENOM" id="CLU_004485_4_0_2"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="79"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU59365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="907" mass="101545" checksum="7577D3EDF2F8C0DF" modified="2012-11-28" version="1">MGKKELAALFSSNPDRYYKVSLFDKMGFARRKCGKCEKFFWTLNDGRQFCPDHENYSFISKPPTSKRLDYVSAWKEVDKFFRANDHTIVRRYPVVCRWREDLYFTIASIVDFQRVVGNQVVFELPANPLVVPQMCLRFNDIENVGLSGRHYTGFCMIGQTCNADAPGGYWKDKCIDLDYGMLTKGLGIKPEEITFVEDVWMGAGAFGYSLEYFVRGLELGNAVFTEFEGNENDYRVMPNKIIDMGAGLERFSWITMGTPTSYDCCFGPVVDKLRDITGTDNGGDVLSRYFEAVSSKLDHTTSVRELRSLIAREMKIDEEKLARLVAPHEAIYTVADHVRTLLFAISDGALPSNVGGGYNLRVILRRALSMLERLGWKNVRVEDIADMHVDYLKQMYPELEEYRQDVRTILQLEAGRYTSSRERMNSVAMLLKTSKKGELSVDDLIRLYDSDGITPDFLVEQGVIQGVPSTFYTKLAELHTNLAAGQTAKPIRGLEGLPPTKLLYYEDETMREFHAKVIKVVDSKYVILDQTAFYPRGGGQEPDTGEIEDTKVVEVTKQADIVIHRIEGNNNKLAEGQSVHAKVNARRRDLITKHHTATHVLNSASRNTLGSWVWQNSAFKEEGYGRLDITHHSALAKEEVQKIEHAANRVIRENHPVIIKTYDRGEAEQEFTFRIYQGGVVPTSNVRIVNIEGWDIEACGGTHVKSTGEIGLVKIVKSERIQDGVVRLEFVAGEAAVNYMQQLDSQLASIAQKLGSSREKVVESFNKSMEEAEAAKKKVRTMLRVVAGPIAKDISDKAKKLGSGVHLHSTYDEELDEDYHIAVGEKAIELDKQLLYVALVSKGQGIRVIVFAGEAARKKVKAGAVAKQVSAKLGGSGGGDDRFGQGGGRSKDRIKEALLLAEEEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHG8</accession>
    <name>K0IHG8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59370">
        <property type="protein sequence ID" value="AFU59370"/>
        <property type="gene ID" value="Ngar_c24460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24460"/>
    <dbReference type="HOGENOM" id="CLU_176748_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2444-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12032" checksum="4109D2AF56ADA58A" modified="2012-11-28" version="1">MSFFGSSSGGPSFDKKKYEHLTLAIKQTVLERARNRCQKCGVKFTPSVQPQFEHINGSKKDNRPINLRALCPECFKEVEEKERKNKGMFGGMRSVLRRIPVDLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHH5</accession>
    <name>K0IHH5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F420-0:gamma-L-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cofE2</name>
        <name evidence="9" type="ordered locus">Ngar_c24560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24560"/>
    <dbReference type="EnsemblBacteria" id="AFU59380">
        <property type="protein sequence ID" value="AFU59380"/>
        <property type="gene ID" value="Ngar_c24560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24560"/>
    <dbReference type="HOGENOM" id="CLU_051152_1_0_2"/>
    <dbReference type="OMA" id="SRTHAMR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043773">
        <property type="term" value="F:coenzyme F420-0 gamma-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="248" mass="27486" checksum="4942D907932512B6" modified="2012-11-28" version="1">MVEILPIRTEVKRGRFDLYESLQEFDYRDDDILVVSSKFVSMSEGAVVNLSRVRVSKKARVLAAKCYMEPKMAELVLRESDHVIRGVPGFLLAIRDGMIAPNAGIDKSNVPKGYAILYPRDPFGTAERLRQKFQTERGIRVGVVIADSRLMPTRIGTTGVAIACAGFEPVEDLRGRRDLFGNVLKYTFKAVADGLATMGVAVMGESDESTPAAVVRGAKVIWSEKKFSWKDMAVSPSQDIYLRGIHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHK1</accession>
    <name>K0IHK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58383">
        <property type="protein sequence ID" value="AFU58383"/>
        <property type="gene ID" value="Ngar_c14470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14470"/>
    <dbReference type="HOGENOM" id="CLU_1943924_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1445-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="15755" checksum="A4C564E2A21C2DE4" modified="2012-11-28" version="1">MEEAEKNIPDEKIIIELDVDPAEFRRVKAEYYRTISCNSFLHLYEKRMQEFDALLELHKNMHEENTILSEFVDYQKYTPSLRHVKEDLQREEENLDRIKKEIKSYELTRKLIKEDIDSFTVDQDRLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHL3</accession>
    <name>K0IHL3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14620"/>
    <dbReference type="EnsemblBacteria" id="AFU58398">
        <property type="protein sequence ID" value="AFU58398"/>
        <property type="gene ID" value="Ngar_c14620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1426"/>
    <dbReference type="HOGENOM" id="CLU_730761_0_0_2"/>
    <dbReference type="OMA" id="GNHENIS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1460-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="385" mass="42119" checksum="1D7A548F9D6FF4C4" modified="2012-11-28" version="1">MSAGGSSVAVYGLSTEGYRIASSIAIKGSKVSLIDESVRMAISLKPDIARTYPNVSSLIEDEPLLDLEPIDVAVSNASYVYFAPRVRKVGPDVKSDVTSKFKDAIKALKRGASVVYMLPTGVGGNNENIALIEHMTGMSVDKDVSYYYLPMSTFTSASSETLIGSVKSKQDNHLSKMLHDPDTRRKLIFVDVNSAELAHVIKTLSHYSGMASILEICKKAADSNIGSELMQGTFADLYIDDVTGGLYDLRIIGSSLDGTGPLMYLVNGSIKGIEGYVKYLIDQIRATLKKRDLKASRTKVAIAWTLDQHEMRGDKIELLSSLETKVKDYIGDVERHQGPTFDLYHTDKTTVVIACSKADYEKVVSKNMANQDFIVMKANPLCETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY3</accession>
    <name>K0IHY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05890"/>
    <dbReference type="EnsemblBacteria" id="AFU57532">
        <property type="protein sequence ID" value="AFU57532"/>
        <property type="gene ID" value="Ngar_c05890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05890"/>
    <dbReference type="HOGENOM" id="CLU_907937_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-587-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="268" mass="31327" checksum="3A4166FD58020069" modified="2012-11-28" version="1">MTIVESLESIMRQSVEPSLVCVVNDGSTDSTSNLLFKLKDSYQNIHIITLEDKGYDSRRIVHNWNIACDYVKKSGKEYDYLLISSDDVVLPKEYVERLIQEMSIDPKLAVVSGNRGLAQSDFISLPEGAGRLIRVSFFSQIGYRHPPYYGYEPWILYKALQMGYRIRKLADLKYEHKRTFGVGHQFIEYGPAMRCLGYHPIFVLARVVRNILTNKTGISKSASLRMLFDYLFEGKWKDDPYFQYFDPELREFIRNLQKQRLFRKLTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0II59</accession>
    <name>K0II59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58633">
        <property type="protein sequence ID" value="AFU58633"/>
        <property type="gene ID" value="Ngar_c17000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17000"/>
    <dbReference type="HOGENOM" id="CLU_2581535_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1698-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9450" checksum="A0629AF90237ABED" modified="2012-11-28" version="1">MYKMEYSRLNNKLIDNNHQKKVFNAFADLAREIERQTARQTHLIDAKIGRARYLVDQKKRLQKKLADVDAELDSMRGDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0II75</accession>
    <name>K0II75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27240"/>
    <dbReference type="EnsemblBacteria" id="AFU59645">
        <property type="protein sequence ID" value="AFU59645"/>
        <property type="gene ID" value="Ngar_c27240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27240"/>
    <dbReference type="HOGENOM" id="CLU_1840649_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2724-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="16197" checksum="60CEDA47B307090D" modified="2012-11-28" version="1">MYKEFGIPTITPALVENRVGGFGFDTLSPDQETIRKVAQGILNYTKTHDKPFIGVPPLYWKQIVDFGRPMFKECGVWKSLTIQANGMVRIPCWKLAVPTQQYNILQYDIGELWNMPEWENLKVCHDCEYLHAYGFHRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE4</accession>
    <name>K0IIE4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58768">
        <property type="protein sequence ID" value="AFU58768"/>
        <property type="gene ID" value="Ngar_c18350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18350"/>
    <dbReference type="HOGENOM" id="CLU_807987_0_0_2"/>
    <dbReference type="OMA" id="IHDQAHP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1833-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="36969" checksum="10BDF9D575D696D7" modified="2012-11-28" version="1">MAQADLPAVMKARSAGFARLWGYSVGFYGVWLAHIGRQTGLLERIAHRPVSVDELVSATKMHPPAVQAWCSAAIAYGLVSEKKDKKMYLKPEMKIMLLDRKNPDYLGGQFSYLALRSLEYGAFQDLFRLGRTREMSYTLGAIEQATDWDHYSFLTAIRRDKKMSRLLSQGCRLLDVGCGTGSLLAKMCAEYPKSSFVGIDPCDKAVAAARKIAKGKPIKIIKQAGESMVFENEFDIVYLGESLYAARDKQKVVSNCRHALEKGGTIAIVEGLLPESRLHGDDSRLIMGMQLDFALQGYRFMTKKEVARLLAKFSRVRFKALGGSVYLVTAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK1</accession>
    <name>K0IIK1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58883">
        <property type="protein sequence ID" value="AFU58883"/>
        <property type="gene ID" value="Ngar_c19510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19510"/>
    <dbReference type="HOGENOM" id="CLU_2597869_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1949-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9560" checksum="47A1EE7BF8CF2CFF" modified="2012-11-28" version="1">MPLAAGTGRLLELWTDEHGEHFAIKISGDADFKAATSRYVKYVRIVDTGLYLADQTYQWKYTLEQWVKNYKKDQQESDGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN7</accession>
    <name>K0IIN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59785">
        <property type="protein sequence ID" value="AFU59785"/>
        <property type="gene ID" value="Ngar_c28660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28660"/>
    <dbReference type="HOGENOM" id="CLU_2379509_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2866-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10751" checksum="730ED8328F06D664" modified="2012-11-28" version="1">MITKKDLDKFMADLQDTEELDRRTKDRAETSLAAAFAGFRQRLAERIAQQKSTAEECRRVGDDVGARYHEALVEIYKSLFNIGDKPVSDDNNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIR6</accession>
    <name>K0IIR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58968">
        <property type="protein sequence ID" value="AFU58968"/>
        <property type="gene ID" value="Ngar_c20360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20360"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2013"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_2"/>
    <dbReference type="OMA" id="TEHEDID"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2034-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="17858" checksum="E6E2B22C9129407C" modified="2012-11-28" version="1">MFKRILVPYDGSEPAGRALDQAVNIAKAHGIIKPEVILLHVIAEFPNYHFIDRPARSIKTGEKIMLSQYLKEVYELMEKNAVDALAKKKDEVKKFSDFEITTKILAGHVSDMIIEFAKKEKVDLIVIGNVGRSGISKIRTLGSVSRSVSERAPCPVMIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU2</accession>
    <name>K0IIU2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) polymerase subunit PhaE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phaE</name>
        <name evidence="4" type="ordered locus">Ngar_c20670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20670"/>
    <dbReference type="EnsemblBacteria" id="AFU58998">
        <property type="protein sequence ID" value="AFU58998"/>
        <property type="gene ID" value="Ngar_c20670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20670"/>
    <dbReference type="HOGENOM" id="CLU_1472030_0_0_2"/>
    <dbReference type="OMA" id="RIWIDIF"/>
    <dbReference type="UniPathway" id="UPA00917"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010123">
        <property type="entry name" value="PHA_synth_III_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09712">
        <property type="entry name" value="PHA_synth_III_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0583">PHB biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="21621" checksum="1DE4BCDB2CC39A87" modified="2012-11-28" version="1">MAENNNKDLQGFTQEQMNKMFSFWTDVMKLPTIGPMYAFSKDVSSYANDFVTLGRVMAELKTNMDSYWSLLSTTFTRAMKETMERAPKQLISKDDFENYRRAAIEAFEDAFTDLFASPEFSSVYGKLFSSQLDVSRAIQGIAEKNSKTLNLPTRSEVDEILKDIAELKRSVRDLKRSLEIRNGQARATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW2</accession>
    <name>K0IIW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Succinate dehydrogenase flavoprotein subunit/fumarate reductase</fullName>
            <ecNumber evidence="11">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdhA</name>
        <name evidence="11" type="ordered locus">Ngar_c20970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20970"/>
    <dbReference type="EnsemblBacteria" id="AFU59028">
        <property type="protein sequence ID" value="AFU59028"/>
        <property type="gene ID" value="Ngar_c20970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2077"/>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_2"/>
    <dbReference type="OMA" id="HWEWHMF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="442"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU59028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="567" mass="63261" checksum="3D9F449C118CDDB8" modified="2012-11-28" version="1">MISHDVLIIGSGLAGLRAAISAAAIDKKLSIAVISKVQVMRSHSVSAEGGTAAVLYEEEGDNQESHIYDTIKGSDFLADQDVAERLVQNMPYEIYQMDHWGMPWSRRKDGRIAQRKFGGYSFPRATFAQDKVGFYLMQTLYDTCQKYDNIHFYNEWFCTSILHENNTFQGITAIELKTGNFTVFKAPAGIICTGGAGRIYSFSTYAYSSTPDGLDMAYRAGLALKDMEFVQFHPTGILPSGILITEGARGEGGYLINSNGERFMQKYAPGKLELAPRDVVSRSMIKEIQEGRGFKHETGVDCLKLDLTHLGAERIKEVLAGIREIGIKFSGIDIIDEPIEVRPVCHYMMGGIHANVDGATEMVGLWAAGEAACNSTHGANRLGANSTSECIVWGRITGELAAKHAQERKAGSVQEQQVLDEEKRIYDGIFRGRGDVNPYEVRKQLTDTMDAKAYVFRNEQGLTEALKKTRELKAAMWKHVDDKAKEYNTNFVNVMEIDSMLRTAEVVLVGALNRRESRGAHARTDYPYRDDANFLKHTLAYFTGNGGPKMTWYPVTFTRYAPVERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX8</accession>
    <name>K0IIX8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59048">
        <property type="protein sequence ID" value="AFU59048"/>
        <property type="gene ID" value="Ngar_c21170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21170"/>
    <dbReference type="HOGENOM" id="CLU_2285137_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2115-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11969" checksum="28254D39C74FF658" modified="2012-11-28" version="1">MNSIYWISSVSLPKAVIFLDRYRDHAKEFADHAKSLSKNKQESKLCDLISEKSNLLWFAYYEGVLTRQDLKKFTSLLDMEMKHFFYGNKSEIWADLFNLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ00</accession>
    <name>K0IJ00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59975">
        <property type="protein sequence ID" value="AFU59975"/>
        <property type="gene ID" value="Ngar_c30590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30590"/>
    <dbReference type="HOGENOM" id="CLU_2406457_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3059-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="9968" checksum="C2550915638E199F" modified="2012-11-28" version="1">MILFATFGNNIVAISDNGISNGVQILSDGDDDNNGQVVPDNFKITYSYGIGLDYTLTVDDTAVGLFTVKNCYSIMPTQHATLALSQQELEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ10</accession>
    <name>K0IJ10_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="7">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">gltX</name>
        <name evidence="11" type="ordered locus">Ngar_c21580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21580"/>
    <dbReference type="EnsemblBacteria" id="AFU59088">
        <property type="protein sequence ID" value="AFU59088"/>
        <property type="gene ID" value="Ngar_c21580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2137"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_2"/>
    <dbReference type="OMA" id="MRFAPNP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="9">
        <location>
            <begin position="104"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="10">
        <location>
            <begin position="410"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU59088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="579" mass="65208" checksum="7813176850ACEDE4" modified="2012-11-28" version="1">MQVDANTEKFIKVIALKNSIEHEGKAQADAVIAKFVGSRPELRSQIKALIPEIKAVVQKINAMPLAAQKLLLEELAPGETAAAKKQAGEQQLQLPPLEGAVQGQVVTRFPPEPNGYPHIGHAKAAIIDEEYARMYGGKLILRFDDTNPLKEKLEYYDAIAEGLEWLGVKPDIVKNTSDDIDLLHSYGRKLIELDGAYVCTCSQDTIHDLRAKGIPCECRRDLATALERAEKMFGGSYDQNEAIVRFKGDMADQNTAMRDPTLFRIIEGDHPKLGSRVRVWPTYDFAAPIEDSIDGVTHAMRTKEYELRNALYFAILERLKLRKPYLIEFSRLEFEGMPVSKRKIRPLIDNGTIKSWDDPRLPTLAAFRKRGFMPEAIRKFVLSLGFTLAETKPPFETLEAFNRKIIDPISPRLFFVKNPIEVHVEGAQETEVVLKNHPTDASLGTRKVRVRDRLYIAGDDAVGLKTGDEIRLIELYNIKITGVSSKNGGRAITAKVGGDEIRQLMPKIQWIAKNDIVEYKVMIPKALYIGEEYNMNSLEIARGFAESFVSGLKPDTRVQFVRFGFCRIDDNQTAIMTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ26</accession>
    <name>K0IJ26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ferritin Dps family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c30990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30990"/>
    <dbReference type="EnsemblBacteria" id="AFU60015">
        <property type="protein sequence ID" value="AFU60015"/>
        <property type="gene ID" value="Ngar_c30990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3073"/>
    <dbReference type="HOGENOM" id="CLU_098183_2_1_2"/>
    <dbReference type="OMA" id="KKYHWDV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3099-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="4">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="166" mass="19509" checksum="B12B2BD8EE50C32E" modified="2012-11-28" version="1">MEKDVKVDIGVKDDARKKLVETLNMRLSDEYVLYTKTRNYHWNVIGPRFSQLHKFFEEQYEILDEMVDEIAERTRQLGGKSLGTLEEFARHSSISEQPGQYPDPQTMISNLLKDHETIIKTLRKNADEADEQYDDMATNDFFLEAVQKHEKMAWMLRAHLEGKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ32</accession>
    <name>K0IJ32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58157">
        <property type="protein sequence ID" value="AFU58157"/>
        <property type="gene ID" value="Ngar_c12170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12170"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1164"/>
    <dbReference type="HOGENOM" id="CLU_1936375_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1215-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="16293" checksum="D9530E72463DE016" modified="2012-11-28" version="1">MTYMVSTALSNRFYMGRIKKRGYLWVTLGFFVISISAHWTFAWFAYIDEQNAHNQPVQAGDYFNKTFRDTMENWQSEFLQLIWQVAGLSFLLYAGSPQSKEEQDRTEEKIDFIIKKLEPENAKRLLEEWDRKYPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ56</accession>
    <name>K0IJ56_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lon proteolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58222">
        <property type="protein sequence ID" value="AFU58222"/>
        <property type="gene ID" value="Ngar_c12820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12820"/>
    <dbReference type="HOGENOM" id="CLU_907983_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1280-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="117"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="306" mass="33047" checksum="1F3134D104BE5070" modified="2012-11-28" version="1">MAIGLAASIAVSLVAYAYSAQQINLLTAELADKSRVLEEQRQQIDEKTVQLGLLNLQIESLENEIAAKTAEAQDLSQTVDAQRNEIQLLKAQAASLQDDIHELEQQIQANENEIALLTGQMQETQSQLESFKRVKVGHYSLAVDQFGKGIVLPIEVEIIPSGEGIVSIDVKNVKYETGFQDSVRTAVLVASEYSDISVSDKDIVIRVINEDDELITIDGGSAGALLTGMIAAGLMDREINPSVLITGTIESDGTVGHIGSVDKKADAATDFGAETILVPEDQEFNHSSINVIGVSDIEDVMRYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ82</accession>
    <name>K0IJ82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c13540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58292">
        <property type="protein sequence ID" value="AFU58292"/>
        <property type="gene ID" value="Ngar_c13540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13540"/>
    <dbReference type="HOGENOM" id="CLU_537072_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1352-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="507" mass="52549" checksum="1DCC84D6DEBA199D" modified="2012-11-28" version="1">MADEEIELAWRLSVEGAEEVKAKISDLHDQFNRGEISTEQYAKGLRSAGSELKTFSDASQLQTRAFMAAHPGLGALSRAMSGFSSILRAGQAASNAMNLAMIATQGTSSNLAALQAEAAAAQRAYNKAVAEFGPESEEASMALDQLNAATAKVREEQDKMAQQSIQNAFTFATSMGIMVSSAVQSIPRIKTELGNLSKSIGETFGKLGGGGNVARALGGMAAIGLGATALATGGFNALIGQSDTVADKLKAIGGIGAIGVGIALEFPAIAKIALIGTAIATATVAIILFRKELADTMAGVAEALAPAGGALMKFFTEDLPAWGTSALSWLSGVFSVAFTSIWQGILAVATTIWDSLKSAFVGFWNGMIGVANAALAGIASGIQGFINSVIDGINALISIYNAAARALGQGTMATVSRISIPVPQIPVISAATGFNGILAQDTIFQAHRGEMVRITPASDVRGGLGGGTTVIHNHHHNYHIEGSVWSERDLKRMIGRGLYYDLRDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB3</accession>
    <name>K0IJB3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpI</name>
        <name evidence="11" type="ordered locus">Ngar_c31940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31940"/>
    <dbReference type="EnsemblBacteria" id="AFU60110">
        <property type="protein sequence ID" value="AFU60110"/>
        <property type="gene ID" value="Ngar_c31940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3179"/>
    <dbReference type="HOGENOM" id="CLU_025558_0_1_2"/>
    <dbReference type="OMA" id="MLRPERM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="708" mass="78465" checksum="22D029F20DEB2282" modified="2012-11-28" version="1">MGLAKLMKATIVLPRMETQEAVSRLAALEWFHPIQNTASEHINPYYDDLLTKAQRLYQDIDEVVKALGIPPETGVLATMFKGAPKGKHDYAAENIQGFIADLEEKSAKLLEGPRKVLEERNRVQRELEEYSNLEALVSNAANLSLNLAAFGKLVNFFANLFVIDAKDEAEIRKSLDDLAIFSTKLNENKTSLVIIGSAEDSERVLKVLRSFGVNPLQIPADMPQNPSEAYAIAKAKVKELEAKAEQMDKEVEKVKQSILTQLLSLQEAARVAKDVLEITRKPGGTKNFAVIEGYIPQEMEDRFKKLTSDYVSIIEDANLTVNSHEGEHSSEPLPSLLTNKKYMHNFQVITETQGLPRYGEVDPTPIIAFVWPIFYGLMFADFGHGLLLFGLGMLFRYRGNGRLKVWGTLIAASGLAATVGGLGTGEMFGFHFDHISFLEPLAHALPVVGLLSVSELTFEEVVKILEVSIAVGIIHLLMAFFLRLRANLKQGNKIMVYTHDVPAIIQYLAVVSLILAAIGSQYDIIGMFLSDNYYETPVPWLTFVFGSWVSVGLVAKAMPPVIIACIVITILGGMKEQKHALAHGKEPEGGGLVGIVVETVMVRTIEMLANTISYSRLGIMLLVHTALLVTVINSYEHGGGLAILIGGNIGIMMIEGLIVYIQTIRLHLYEWFPKWYKSDGVQFKKLVPQMLYTNLVWKYDDGKKKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB4</accession>
    <name>K0IJB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59193">
        <property type="protein sequence ID" value="AFU59193"/>
        <property type="gene ID" value="Ngar_c22630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22630"/>
    <dbReference type="HOGENOM" id="CLU_1393619_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2261-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="195" mass="21773" checksum="C1B5B422F8AC0775" modified="2012-11-28" version="1">MSAEIAIIAGSSVAGAISAAFIEKLSRLWGGDKKKPRPTNAVRAELLSLLFEKNLAAEAITRVYEASQEGRIDRLERDRLLLKYKQQLDSLNQKIAIVQPVADFADITELRNNLVSLLENKISALDQKLMQMKPGISPPDVIDARVQKIIAETSKVQTTPVDQKPFKAEEKSIDQLQKEIVQALQRLEQVEIDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK5</accession>
    <name>K0IJK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60210">
        <property type="protein sequence ID" value="AFU60210"/>
        <property type="gene ID" value="Ngar_c32950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32950"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="OMA" id="NMNGEIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3295-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13650" checksum="0364836DC0BB4A84" modified="2012-11-28" version="1">MQLDNSIRFAGLANHMGSLISYELRKGLVPLLNEEELKSYTLKTVLRMKTREDYESKLGDVIYTFALYKKIKRATIPLDHPNLAALTVSFDMAADHEGIIIDKILPMIRREKLLTTAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC4</accession>
    <name>K0IKC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18900"/>
    <dbReference type="EnsemblBacteria" id="AFU58822">
        <property type="protein sequence ID" value="AFU58822"/>
        <property type="gene ID" value="Ngar_c18900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18900"/>
    <dbReference type="HOGENOM" id="CLU_2433963_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1888-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10654" checksum="E7276FD967ACA045" modified="2012-11-28" version="1">MPLMNGFELFKNIRKIDRKVKVCFITAFEIYFDEFRRVFPKIDVSCFVRKPITINQLAKIVREELARPIQEEDKPAIEQIQPKGTDPKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF3</accession>
    <name>K0IKF3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c28020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28020"/>
    <dbReference type="EnsemblBacteria" id="AFU59723">
        <property type="protein sequence ID" value="AFU59723"/>
        <property type="gene ID" value="Ngar_c28020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28020"/>
    <dbReference type="HOGENOM" id="CLU_549387_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2802-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="496" mass="58275" checksum="CD73E1CF9535165E" modified="2012-11-28" version="1">MPITLATLQSKIQSEVQSRINARLVKEYDAFHELNRISESRRKNNLKGIIYYSKWLASKYPSMTLYKVNNRELHILPFLNQYRKTAKQDPEEKWVTTWNDYRSRLIHFFRWLHNTKMKGKASDEVPIEDWETPDFVRIKKQKTKRKNTYSVSETWERDEILTILPYEIKMRNKAIIATLWDLDGRNHEAAKMKNKNVRYLEKCALAEVPFQTKTGGGPAVLRMAFSYLLKWKLEHPFRNDPEAPLFCNTRSDHLGEPLDPDYIWRITDNLKKRIKKLVETGAIKDEKEREKLEFLLRTKKWNPYCFRTSAIREDATYLSHFALTQKVRWVPNTRQASKYMAQTLSKDVVNTILAHDGIVVQESKPRAVISNCPRCQEVNPLEYDICSRCSYPLTERGFQQIKEEEDSMKKQLEEMQKRQQKIEAELNSMHHITRFASLVSASPDGMTIDELMMALKSSELEKVASDMKRDMDMTITKMAGGKVKVQFAYQAAKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI0</accession>
    <name>K0IKI0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inosine-5'-monophosphate dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20150"/>
    <dbReference type="EnsemblBacteria" id="AFU58947">
        <property type="protein sequence ID" value="AFU58947"/>
        <property type="gene ID" value="Ngar_c20150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1992"/>
    <dbReference type="HOGENOM" id="CLU_076812_3_0_2"/>
    <dbReference type="OMA" id="GMIIKSD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2013-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="230"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="284" mass="31333" checksum="F174F7FB07769C58" modified="2012-11-28" version="1">MCNVAYTMYIVGLDAKGAMWKPVTLGPDETVLDARDILLRYGISRVVIAKNHKPLGIVTEKDIARFLYEQVPPRQLDEIRLDEVMSRSLVTVGEETDLRACAKVMLAKGVSSLVVVDGKKNLKGIFTKTDLTTAYVEYYAMEHRVREFMTKKVITVAPDEPVHSAIMLMIVNKISRIVVTRNGRLVGMITGRDLLPLGAMVERRQPWNVKKWQPFIPAGIKAAMLVSDVMTPNPVTTTADSDLADAGYIMLRNRISGLPVVDSKQAVAGIVTKTDVVKALASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK6</accession>
    <name>K0IKK6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59818">
        <property type="protein sequence ID" value="AFU59818"/>
        <property type="gene ID" value="Ngar_c28990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28990"/>
    <dbReference type="HOGENOM" id="CLU_1745604_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2899-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="15432" checksum="9B22AE74E65C6398" modified="2012-11-28" version="1">MDDNTVVAEPTSSTNTSELISAPFGTLTVSTSGTAITKVRPDKFSVTVGVETNGTIAGEAASNNADLIAAVIAALRNLGTAEDEISTRQYNVYPVYSRSDPVNACMVLPGNPVPPECYVSGEMVSYKAVNTVTVITLDADGDVDAGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS7</accession>
    <name>K0IKS7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trxA4</name>
        <name evidence="2" type="ordered locus">Ngar_c30370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30370"/>
    <dbReference type="EnsemblBacteria" id="AFU59953">
        <property type="protein sequence ID" value="AFU59953"/>
        <property type="gene ID" value="Ngar_c30370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30370"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3007"/>
    <dbReference type="HOGENOM" id="CLU_090389_2_0_2"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16244" checksum="3CC428A0C2C9C861" modified="2012-11-28" version="1">MSNSDDELEAIKQRKMAELQKVAAIKAMMSALSEPIVLTDSNFKSEVEKYPLMLVDFWAPWCGPCRMVSPTIEQLAREYSGRVAFGKVNVDENQMIAASFGIQSIPTMIIFKNGKVVDMMIGAMPKGQIEMKLKQQLSNNSSSIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT5</accession>
    <name>K0IKT5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59973">
        <property type="protein sequence ID" value="AFU59973"/>
        <property type="gene ID" value="Ngar_c30570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30570"/>
    <dbReference type="HOGENOM" id="CLU_3003270_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3057-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6585" checksum="4EB8C0A0A4D95905" modified="2012-11-28" version="1">MLTNNTEDLPEVKAFLAKYPDADAHTDRSGRLVVDYRQDYLEVMLNRIGTEYYPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKU2</accession>
    <name>K0IKU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59993">
        <property type="protein sequence ID" value="AFU59993"/>
        <property type="gene ID" value="Ngar_c30770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30770"/>
    <dbReference type="HOGENOM" id="CLU_2366307_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3077-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10220" checksum="6F47B768FC909BA0" modified="2012-11-28" version="1">MPRQETRTFIFATSWLILSIAAFTVVVRQKSVLVSALLVISGLILTIDGLIVTRNLTVVYFLGPAIGFIFALIVLALGIAKSVITATKKSSISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL08</accession>
    <name>K0IL08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60093">
        <property type="protein sequence ID" value="AFU60093"/>
        <property type="gene ID" value="Ngar_c31770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31770"/>
    <dbReference type="HOGENOM" id="CLU_1248319_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3177-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="25166" checksum="9A7F8B8CC9373AF2" modified="2012-11-28" version="1">MRKYYLFPILYVLKASYVLAAAVAVATLVPITLALARIGPEIEIGGQQTLGVYDNAESRIEDARGDAEAVYQQIGTEEIPEVKDYHDILGASVVKRDEAFFFTIDLAGNPNNNTDFETLYRWHIITTSPITNREQQYTIMFPNFARGNSTTDGWYFAVYDETVNTFIVRPTRITEMPEDRVEFPVEDFYIGAPTRFIYWVDVSVRLNGTLGQPDYLMDYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC0</accession>
    <name>K0ILC0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">Ngar_c00520</name>
        <name evidence="8" type="ordered locus">Ngar_c33930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Enrichment culture Ga9.2</strain>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00520"/>
    <dbReference type="EnsemblBacteria" id="AFU57002">
        <property type="protein sequence ID" value="AFU57002"/>
        <property type="gene ID" value="Ngar_c00520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60308">
        <property type="protein sequence ID" value="AFU60308"/>
        <property type="gene ID" value="Ngar_c33930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00520"/>
    <dbReference type="KEGG" id="nga:Ngar_c33930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3387"/>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OMA" id="YESARTW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14697" checksum="177CA7D5E7E3DBB4" modified="2012-11-28" version="1">MVCVDTDFIIDLGRGSQKAFDKLQELEDRGENTFFTTAITVAELYYGAYRAKDRARALADTKNDLSKFSILNLDYESARTWAELAEQTKSNSIGELDLFIASIALANKQILLTRNVKHFERVPGLVVESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG7</accession>
    <name>K0ILG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c01190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57069">
        <property type="protein sequence ID" value="AFU57069"/>
        <property type="gene ID" value="Ngar_c01190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01190"/>
    <dbReference type="HOGENOM" id="CLU_032903_9_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-119-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="13660" checksum="41AD3F6AEBBD448D" modified="2012-11-28" version="1">MQDFLHKISRYYADRYDIIVLFLERLCTPNLVRNHRVAKHILDSGWRTFKQSLKYKAKMVLEVNPKNTSIDCSKCGNKVPKTLAVKTHRCDRCHIAIDRDYNASRNIKNRKTCNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ4</accession>
    <name>K0ILJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycoside hydrolase family 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57114">
        <property type="protein sequence ID" value="AFU57114"/>
        <property type="gene ID" value="Ngar_c01650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01650"/>
    <dbReference type="HOGENOM" id="CLU_2505055_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-165-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="10324" checksum="E3B07AFCDC557CF6" modified="2012-11-28" version="1">MIGKIIKENHDRLPEYKRKDVKAVENGSGERPIKDTYYRTFIYLVKLMREYNYDERLVYRNFPFKTKDVVFSTSFYVSNKCLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL5</accession>
    <name>K0ILL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60493">
        <property type="protein sequence ID" value="AFU60493"/>
        <property type="gene ID" value="Ngar_c35800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35800"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3587"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3581-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13826" checksum="8062A8D89CC49A67" modified="2012-11-28" version="1">METKIPVIQDCSFAGYDPSSLMSETARLRRIITKRGTLEILIPLCCSTQPVRYKQFRQALKGISSKTLASRLKELEKGGILERKAYSEIPPRVEYRLTGKGQELVESVMYLLQWMKKWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT9</accession>
    <name>K0ILT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TatA subunit of twin-arginine targeting system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tatA2</name>
        <name evidence="9" type="ordered locus">Ngar_c27460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27460"/>
    <dbReference type="EnsemblBacteria" id="AFU59667">
        <property type="protein sequence ID" value="AFU59667"/>
        <property type="gene ID" value="Ngar_c27460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27460"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2722"/>
    <dbReference type="HOGENOM" id="CLU_086034_3_2_2"/>
    <dbReference type="OMA" id="EWIVILI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="11955" checksum="00958B815847274A" modified="2012-11-28" version="1">MVAEGLSGLIMQFVGGWEWIIIIGLIVVVFFGAKKIPELARSFGKATAEFEKARIEAKRELQEMKSEGRVGREKLEAIADSLGIDYTNKNDEELRAAIEVELNKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX8</accession>
    <name>K0ILX8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59777">
        <property type="protein sequence ID" value="AFU59777"/>
        <property type="gene ID" value="Ngar_c28580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28580"/>
    <dbReference type="HOGENOM" id="CLU_3094234_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2858-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="6111" checksum="A7DA986A78215956" modified="2012-11-28" version="1">MLRAVRQMFCSHKESFAYRKYGEFYFVEFSNCAKCGKTLKRLQGFDEDMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ8</accession>
    <name>K0ILZ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57469">
        <property type="protein sequence ID" value="AFU57469"/>
        <property type="gene ID" value="Ngar_c05260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05260"/>
    <dbReference type="HOGENOM" id="CLU_1933324_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-524-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14883" checksum="6D5F19D34CBCFC58" modified="2012-11-28" version="1">MRIRISARPQGKSPKQLDELVWGYNREFLLYWVDTIIETANQLYTEDVKTVVEKNEQEGRNDVAYCLQKPIHLATRLWDINGYAPIEIEVPDAKGYKCVSEAISLHIANMPLTIREMFANISQIATATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM22</accession>
    <name>K0IM22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine and succinylornithine aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argD2</name>
        <name evidence="4" type="ordered locus">Ngar_c29940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29940"/>
    <dbReference type="EnsemblBacteria" id="AFU59912">
        <property type="protein sequence ID" value="AFU59912"/>
        <property type="gene ID" value="Ngar_c29940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2966"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="394" mass="43361" checksum="40A09FD7BB013B96" modified="2012-11-28" version="1">MNGEDQHLAALYQRFPVNLARGKGARVWDTAGKEYIDCMGGYGVALVGHCNDRVVAAIKKQADMLITAHMSVYNDTRLKFMDKMSTVVPPGLTKMFFTNSGAESVEGALKFARKYTGKHGVIAMNGAYHGKTFGALSVTYNEKYRKSFMPLLDGVKFVPYSDPGKLEEAIDDTIGTVILEPIQGETGIIVPPDDLLPKIREICNRRNLVLIFDEIQAGLGRTGKMWAGQNWNTTPDIMCLAKGIAGGIPMGLILAKREIMEATKLGEHSSTFGGSPIACAAGTATLEALTEDKLVENAAKMGRHWREGLNRLKEKHKIIREVRGLGMMIGVELRFEVKDVLFDGIRNGLLMLYSGRNIIRLLPPLVMDETTVSRAVDIMDAVLTSEEKRRNVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM33</accession>
    <name>K0IM33_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">grpE</name>
        <name evidence="6" type="ordered locus">Ngar_c30360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30360"/>
    <dbReference type="EnsemblBacteria" id="AFU59952">
        <property type="protein sequence ID" value="AFU59952"/>
        <property type="gene ID" value="Ngar_c30360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30360"/>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_2"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="22683" checksum="8865EB5AF50B78A1" modified="2012-11-28" version="1">MEKDETLEQQQPHDDEKPVEQDLEALRSELQSVKEELRKAKESSDDSLNKLKYLIADFDNYRKQMEKQAATKVETAKAELLLKFLNIRDDYLRALSVAKQAKTETVVIEGLEGILKNIDSLLASEGVREIETVGTPFDPNVHDAIAYSARDDIEENTVTAEIRKGYMLNSKVLRPSLVEIAKKIVKNSVSDTTKEDTGDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM63</accession>
    <name>K0IM63_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57594">
        <property type="protein sequence ID" value="AFU57594"/>
        <property type="gene ID" value="Ngar_c06510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06510"/>
    <dbReference type="HOGENOM" id="CLU_2784236_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-649-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7782" checksum="02871D3F1BC444B6" modified="2012-11-28" version="1">MPGEEYRDLVICNNCLWAMSLLKGSHGFIACQMCGNISLDVIIPVNDYEAYTMNVRNKNIELELTKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM74</accession>
    <name>K0IM74_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60062">
        <property type="protein sequence ID" value="AFU60062"/>
        <property type="gene ID" value="Ngar_c31460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31460"/>
    <dbReference type="HOGENOM" id="CLU_2613760_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3146-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="7562" checksum="86339632F4CA264D" modified="2012-11-28" version="1">MSGKPKMPAKSRGEGGVSASGDGGTTWAGGEDGGGGFIEECPGNGFEDVEGGDAPSAGPEGIPNPGADTLPSDDELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA0</accession>
    <name>K0IMA0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57679">
        <property type="protein sequence ID" value="AFU57679"/>
        <property type="gene ID" value="Ngar_c07360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07360"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-734-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11838" checksum="A0AA3C295118F12A" modified="2012-11-28" version="1">MQREEKVRNRSKLDIIYDILASATGGVRKTHIMSRANLSSEQMNFYFNTLLHHSLLDAEKDSDDNLVYRTTQKGIKFLHCCAQIKSLIAPIVKVRTQGELLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB0</accession>
    <name>K0IMB0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57714">
        <property type="protein sequence ID" value="AFU57714"/>
        <property type="gene ID" value="Ngar_c07720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07720"/>
    <dbReference type="HOGENOM" id="CLU_3338597_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-770-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="39" mass="4303" checksum="967F34FAF528834F" modified="2012-11-28" version="1">MAGNKRGNKQYGKNAAKDESTDSKKNKKKGMAHRKIAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC6</accession>
    <name>K0IMC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57779">
        <property type="protein sequence ID" value="AFU57779"/>
        <property type="gene ID" value="Ngar_c08370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08370"/>
    <dbReference type="HOGENOM" id="CLU_2217135_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-835-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="12106" checksum="8F15830C8BFD111D" modified="2012-11-28" version="1">MAEEISLSSGSTSATEHQQYFATVRELLSKVVAGVKNGNYEQADQYAITAYLDNYEYLEVPIEEHYPELMLDIEMEMREELRAKIQEEESPEACRASKEITCGFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME3</accession>
    <name>K0IME3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaJ3</name>
        <name evidence="2" type="ordered locus">Ngar_c32770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32770"/>
    <dbReference type="EnsemblBacteria" id="AFU60192">
        <property type="protein sequence ID" value="AFU60192"/>
        <property type="gene ID" value="Ngar_c32770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32770"/>
    <dbReference type="HOGENOM" id="CLU_1529282_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="20308" checksum="9B7D2107CB1F493F" modified="2012-11-28" version="1">MNYYAVLGISPDATADEVRQAYFRLAKLYHPDRNKSPEATEKMAEINLAYETLRDEHRRKEYDLENRITINSKERFTVQYEDEEEIGRQPGPFGKCVRCNFVNNSGVFVCSTCGNVFDPHAKHEDKERDEEYEEKTTEDVLSEIIRCPQCNEVNTYSRGSCWQCGLVFGIDEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML0</accession>
    <name>K0IML0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC uptake transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c10420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10420"/>
    <dbReference type="EnsemblBacteria" id="AFU57984">
        <property type="protein sequence ID" value="AFU57984"/>
        <property type="gene ID" value="Ngar_c10420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10420"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="QSIVTFP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1040-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="274" mass="30938" checksum="A7FF4256A233DE19" modified="2012-11-28" version="1">MAQIEQMYGKNVILELKEVSKTFLQSEKNDSGPTRRHVVLDRLNLRIREGEFVTIVGTSGCGKSTLLNIIAGLDAPDSGLISVKSNNNKNIGKAERVVIFQEGALFPWLTVTDNVEFGLKIARIPKELRKEIASNFIDMVHLTRFADSYVYQLSGGMKQRVAIARALALDAQILLMDEPFAALDVQTREILHEQLLQIHKSTGKTILFVTHNINEAVQLGDRIILLSPHTRSIKREIVIDYPKPRDIESPEISAIRRELLNELQEDFRFAKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV0</accession>
    <name>K0IMV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58259">
        <property type="protein sequence ID" value="AFU58259"/>
        <property type="gene ID" value="Ngar_c13210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13210"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="OMA" id="MVEDYKS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1319-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="144" mass="16617" checksum="6E341DB496844765" modified="2012-11-28" version="1">MPYKLRTYVGIDYEFLNSFCKNVLAKDKSIRWAGLVNKNGIILTQEVREGVKLLLTEEENEEYAATAIARQKTRGKFESKIGKMVYAFGRYDRLLRATIPINENYYLLVTFDVEEKNFDSIITGKIVPSIAENKSRFITMDDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX1</accession>
    <name>K0IMX1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c14280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14280"/>
    <dbReference type="EnsemblBacteria" id="AFU58364">
        <property type="protein sequence ID" value="AFU58364"/>
        <property type="gene ID" value="Ngar_c14280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14280"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1394"/>
    <dbReference type="HOGENOM" id="CLU_060471_4_1_2"/>
    <dbReference type="OMA" id="VEAYHHT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1426-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="22552" checksum="31C80A4BA3298746" modified="2012-11-28" version="1">MSCPPISFYRRPTEVVARDLVGKKLVRTIRENGRIFRLAGTIVETEAYGYSDDPASHACMGPTARNRVMFGDVGRAYVYFTYGNHFCVNVSARSSTIEAGAVLIRGLEPVEGIEIMKKLRPVDDAFSLTSGPGKLTQALNISSALNGVDMTNPESELHIEFGISKSIRIMATPRIGITRAVDRKWRFVDPASPYVSRRIQIKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX6</accession>
    <name>K0IMX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14530"/>
    <dbReference type="EnsemblBacteria" id="AFU58389">
        <property type="protein sequence ID" value="AFU58389"/>
        <property type="gene ID" value="Ngar_c14530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14530"/>
    <dbReference type="HOGENOM" id="CLU_033401_4_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1451-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="19512" checksum="B680E0FF10B93698" modified="2012-11-28" version="1">MTYIYERQRWTDVSEEGFRLLSEGKVQEFNSWRMKNLTVKLDFTGKDLSGKNVSGAYLNGLVADRTNFSRANLAGTNLVQASLNGANFECADLTGTLLMYAEMKEARLANANLTKTNLMWANLQGTDLTGCRMSQTVFVEANLQNAKVTGADKAGAYLKYAKLDGTTWFEQVAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN00</accession>
    <name>K0IN00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58509">
        <property type="protein sequence ID" value="AFU58509"/>
        <property type="gene ID" value="Ngar_c15760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15760"/>
    <dbReference type="HOGENOM" id="CLU_1954730_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1574-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="15035" checksum="3BC15CA5F31B3736" modified="2012-11-28" version="1">MVDSVPEVKREAVTYRLPPRILKKIKEESSRSGHTNNNVVELWLSDHIAELEKPRFTPYKIINNSKVVLYDRQESELVIVYLAEDSDELIHLECEKHVGFKKCDHIDFVKNIPTIKEWIKEAKAETKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN10</accession>
    <name>K0IN10_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58559">
        <property type="protein sequence ID" value="AFU58559"/>
        <property type="gene ID" value="Ngar_c16260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16260"/>
    <dbReference type="HOGENOM" id="CLU_2127717_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1624-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12676" checksum="1F042DE93DE7E22A" modified="2012-11-28" version="1">MPSVEEHAARLQSLGFDDAMIESFSKEWRALADDGYEMYAIYTGADGSALEDKKACVICSKSDSGLRWEKVITPSQDSAAIYSVCKSCDDQYVETAIRQKALGRLLKERNTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN53</accession>
    <name>K0IN53_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58774">
        <property type="protein sequence ID" value="AFU58774"/>
        <property type="gene ID" value="Ngar_c18410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18410"/>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1839-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20955" checksum="8E588D0F95C16F11" modified="2012-11-28" version="1">MPVLAEDARTSITRSFRFETDVLKMLDEEAERMGISVNALVGIVLRRYTEFTRYLSKIDMVVINREILTSLLEQLDEEELCKLGLKLGETVMSDTVIFWKKETSEAAVMEYIEKVICRYGHLGTYDEKQMPGGAIAIVVRHRLGKKGSRFLEGYLQAGLRTMLGINAIFEVTDSSIKCELPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN55</accession>
    <name>K0IN55_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58784">
        <property type="protein sequence ID" value="AFU58784"/>
        <property type="gene ID" value="Ngar_c18510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18510"/>
    <dbReference type="HOGENOM" id="CLU_2067881_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1849-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="13697" checksum="B6EC7509AB7CFAD5" modified="2012-11-28" version="1">MAAIEHVFRIFRQAIYDSLLCELQEIKLFGRIELDEALFGSRRKGGKRGWGVEGKTLVFGIYRRNAWQGYHVSCIGQKKGDVDSVDTTAYKKRLVVLFRRPYCVCRFESDWQTSDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN61</accession>
    <name>K0IN61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58814">
        <property type="protein sequence ID" value="AFU58814"/>
        <property type="gene ID" value="Ngar_c18820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18820"/>
    <dbReference type="HOGENOM" id="CLU_2968569_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1880-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6563" checksum="A6A1D1F27E6A90C8" modified="2012-11-28" version="1">MTSQALNKIAKLCAIAEARSTGMKKCKCGMSDGEHALLRRKMMIFFKLQVANLKHFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN88</accession>
    <name>K0IN88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20170"/>
    <dbReference type="EnsemblBacteria" id="AFU58949">
        <property type="protein sequence ID" value="AFU58949"/>
        <property type="gene ID" value="Ngar_c20170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20170"/>
    <dbReference type="HOGENOM" id="CLU_2613753_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2015-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8751" checksum="3C030CD32FDD4DAD" modified="2012-11-28" version="1">MDLKGRRGFAFDTRLDSRLSGSADRFVEKRLQELGTDIIRPRASALVVCEKGAKPEDTMLKEGWKTSSNRLEKSLGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN97</accession>
    <name>K0IN97_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58994">
        <property type="protein sequence ID" value="AFU58994"/>
        <property type="gene ID" value="Ngar_c20620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20620"/>
    <dbReference type="HOGENOM" id="CLU_1521917_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2060-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="20070" checksum="CCE6F13115A0FD59" modified="2012-11-28" version="1">MKEPDDFIVIENDILLTKDGMPAAYCYISKVLIDTLRDEFKHEKVACSSHVYRIQLNKEYAEYAPYIVQVMNSRLGQALTRRFISGSVTPTIRSEDIDNVLVPLPKQDKDVILKKAKQQVETLQSHVMEIMKNVQPSNDLTKVIYDLASLSEPSIPNLPVNWSGGGRRDLHGYYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA2</accession>
    <name>K0INA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59019">
        <property type="protein sequence ID" value="AFU59019"/>
        <property type="gene ID" value="Ngar_c20880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20880"/>
    <dbReference type="HOGENOM" id="CLU_2152486_0_0_2"/>
    <dbReference type="OMA" id="CTHEAGA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2086-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12193" checksum="FFB716B4EDB851E9" modified="2012-11-28" version="1">MTLEELRQKAFFQNTIDVWIMYCAERNRNWYDIDAYRRFISHLNAKGVKMQKFPLCIKESGGMYERGKDKAQFLDQLSKIPSDDAAAYTLKLSGDVIAAIRSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH7</accession>
    <name>K0INH7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59394">
        <property type="protein sequence ID" value="AFU59394"/>
        <property type="gene ID" value="Ngar_c24700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24700"/>
    <dbReference type="HOGENOM" id="CLU_1514666_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2468-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="177" mass="20452" checksum="07716BF6A2E38716" modified="2012-11-28" version="1">MTHAFEDESLGLELKGYSLVANSALETKIAIYTPEIVQSILSENPEIVDRWLQNLHNEYIRKKKSCDFENDPVACFTVSAYEQFEKHFKSWQDGGIIAITLPHDRVIRISKDPLISVIADSKNSSYLVCNKCMTSFTDLDEFEKHCRQETEAKPVEKKKKREKLYEVAPNPIWWLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN8</accession>
    <name>K0INN8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59699">
        <property type="protein sequence ID" value="AFU59699"/>
        <property type="gene ID" value="Ngar_c27780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27780"/>
    <dbReference type="HOGENOM" id="CLU_632563_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2778-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="433" mass="47257" checksum="A5C1E6226A264A4A" modified="2012-11-28" version="1">MRQAIVLGIVGIFLSSLFIMSQTARYQAHATTGLNLGTPSLLNTNGDVLDTAGIRSQVMLSTTISNPQSARQPFITLFEVRDSNQVTVFLSWVSGTIPPGEQFDLGVMWQPQTTGSYNVRTYAVTDLKNPQILSAAKTATVSVGQTSVVAQTQPTPSQSSGNQNNSNEPKGSLVAGISEFSVQGDGKENGSYTIVFSLFDAGKREISSDGKVSFSITDGMNRQLYNKSFSVTSSQFSTWHYTFTGAEFLGYGWTIPTSEIQKGITSTGTAKIVFTDPAGISFTSTTSLVSIPALSQEEAKQKLDEIFTQTATIVNDKRQNGNIEVTLVKYGMFTHPQFTTYGDVVNEFRVDLIVRNIGTTDEYPPDQFVIIDKQGIQHDKSYGGTLPFSELLAGSTVQGSVLFDSITNEMDVSTFVAKKYSYPQDYIWTYYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ5</accession>
    <name>K0INQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Blue (Type 1) copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28650"/>
    <dbReference type="EnsemblBacteria" id="AFU59784">
        <property type="protein sequence ID" value="AFU59784"/>
        <property type="gene ID" value="Ngar_c28650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28650"/>
    <dbReference type="HOGENOM" id="CLU_1500326_0_0_2"/>
    <dbReference type="OMA" id="WVNEDTT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2865-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="154" mass="16334" checksum="D4E69FE99C72933B" modified="2012-11-28" version="1">MLGAITGYLTYTYFTAAIPQAGIVESPYRKELSASATDEGTGQAAGDQVDKTKFSNVVTIRILQGAAAQGSPDYDPDAAVVPSDALITWVNEDTTLHTATSGKDMSDPDKGKLFDTSYLQPGGEYSIPAADIGSGEHVYFCELHPYMVSTVTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR7</accession>
    <name>K0INR7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59844">
        <property type="protein sequence ID" value="AFU59844"/>
        <property type="gene ID" value="Ngar_c29260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29260"/>
    <dbReference type="HOGENOM" id="CLU_1122648_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2926-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="247" mass="27157" checksum="AD9171182FB9CB8E" modified="2012-11-28" version="1">MDKIDADISAFLIFAGVLDNNAKLLSFRRGKASFSLPIERHDTLDVQLSLMFSLIRQLEDISGPHKFTVTRFARHDIFLFGTADMHVFVITSPTSEGQVAKTLSELVATMSDSELPMAAPNLVGGGKKDQTMTAAATTTTMASVRHNNNNDGELNGIDRQQHKLSLATAAKPRPEAIAMLQGYLMALEADCIIQDDANGYYKVKAGESDRLTWSVLEKVSHTFKDRIEIHHVGLDTDGKVLVRISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY0</accession>
    <name>K0INY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60159">
        <property type="protein sequence ID" value="AFU60159"/>
        <property type="gene ID" value="Ngar_c32430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32430"/>
    <dbReference type="HOGENOM" id="CLU_2911658_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3243-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6390" checksum="82CA73C8469FD6FD" modified="2012-11-28" version="1">MPTSATPALKNAIGTTLTTARGAHKHAVVVPKNAEGWLDKKNTEPPSSFLSSGVCNSIEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP03</accession>
    <name>K0IP03_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nrgA2</name>
        <name evidence="10" type="ordered locus">Ngar_c33590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33590"/>
    <dbReference type="EnsemblBacteria" id="AFU60274">
        <property type="protein sequence ID" value="AFU60274"/>
        <property type="gene ID" value="Ngar_c33590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3348"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_2"/>
    <dbReference type="OMA" id="ITPACGE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="91"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="519" mass="54842" checksum="8935231B7217AD4C" modified="2012-11-28" version="1">MHFDALGITKKRTKLGTLEIMVVAVASLLLFSTGSALPQDAFAYTANDPAVPYHCFIDQNGDGAITAADEVEDEEGNMALVPCEVSPGDNAWMMTAAALVLVMTPAGLAMFYGGLARQKNAVNTIHMVFITTGVIAVQWVLWGYSLAFGPDATGQGFIGDFSWVGLQNVLHDVPSNAYYGINSDGGRNAIPHQTYMVFQMMFAIITPALIVASLAERMKFSAFIIFIVIWATFVYDFAAHWTWQITATDNYGRTPGYCGFGWGGCLGALDFAGGTVIHITSGWSGLVIALMLGRRLGYGKMPMEPHNVSLVVLGAALLWFGWFGFNAGSAAAAATNATSAFVATQIATGMAAVTWALVSWGHTGRPSTVGAASGAVAGLVAITPASGFVSPMSAIVIGIAAGIGCYYAVTFKNRRKWDDALDTWAIHGIGGLIGALLTGTFAEQRFTPWGDNGLAFGNPAQLYENAVGAFAALAWAMGITAIIIKVMDVVWPGGIRVTPKEEEIGLDLAQHGERAYVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP14</accession>
    <name>K0IP14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60329">
        <property type="protein sequence ID" value="AFU60329"/>
        <property type="gene ID" value="Ngar_c34140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34140"/>
    <dbReference type="HOGENOM" id="CLU_092801_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3415-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="23719" checksum="2E7D42DA744DB3CC" modified="2012-11-28" version="1">MAQVDWYIEGAEFSNCNCDYACPCQFESRRPTHGDCRGFAAVRIDKGHFGDVALDGLGAALLYAWPGPIYEGNGECQAVIDERADGKQRDALATVLYGGETNKGATHWWVYRMMSSTVHPPLFKHIEFDVDIERRKARIVIPDVLESTARPIRSPATGAEHRVRINLPNGIEFDLAEIGSGTTKTMASIALDLKDTYCHFTVLRQSGKGVVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0I772</accession>
    <name>K0I772_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication factor C large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfcL</name>
        <name evidence="2" type="ordered locus">Ngar_c01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01620"/>
    <dbReference type="EnsemblBacteria" id="AFU57111">
        <property type="protein sequence ID" value="AFU57111"/>
        <property type="gene ID" value="Ngar_c01620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.161"/>
    <dbReference type="HOGENOM" id="CLU_027255_1_1_2"/>
    <dbReference type="OMA" id="GGWTRYG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="412" mass="46025" checksum="C511D6CB0BBDA1D0" modified="2012-11-28" version="1">MMWSEKHRPKTVQEMVGNEDTRLAALKWLAGWVSGSKPLLLVGPPGTGKTTLVHALARQFDYDLVEMNASDARNKDILRARITPVFQNTANLLGRKIMLFLDEVDGISGREDTGGLDTLVELMKEPTVPVIMAANEKSIKIKDLSKVCKTVEFSPVPPRLLLLFLDHVLQSEGAKLGPRDKISIVNNSRGDIRSMLNSAQSRVAGYATVSNRDIVDIDIVDAVNGYFNASSLEQATRFITKADALYPDPRYGMSQEDRRKDMLAALFSSIVSSHVEHDDMASMLEVLSRADMMVGRANARREWRLLKYISSMIASGLYERSRQKGIKYSQYAMPWPVMGPIFARSQSTRKILGELAPALHMSRSSAGSFALPYFIRLIIEEKVDPIEFAVDNFRDESVGESIAKEIEKAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7Q9</accession>
    <name>K0I7Q9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03130</name>
        <name evidence="2" type="ordered locus">Ngar_c03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57261">
        <property type="protein sequence ID" value="AFU57261"/>
        <property type="gene ID" value="Ngar_c03130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57291">
        <property type="protein sequence ID" value="AFU57291"/>
        <property type="gene ID" value="Ngar_c03430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03130"/>
    <dbReference type="KEGG" id="nga:Ngar_c03430"/>
    <dbReference type="HOGENOM" id="CLU_2949417_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-313-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6650" checksum="95D73D10184C046B" modified="2012-11-28" version="1">MGEYTSATISVKRYNGLKQAAEREGRSITGQLDWILKNAGVPEIDNEQTQTVRVDRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7V2</accession>
    <name>K0I7V2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG1</name>
        <name evidence="1" type="ordered locus">Ngar_c03990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03990"/>
    <dbReference type="EnsemblBacteria" id="AFU57346">
        <property type="protein sequence ID" value="AFU57346"/>
        <property type="gene ID" value="Ngar_c03990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.382"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_2"/>
    <dbReference type="OMA" id="EAQVMAM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="251" mass="26908" checksum="E48E96DE36E8B77D" modified="2012-11-28" version="1">MIKGKVAMVTGAGGGVGKAISKRLASEGCKVVLLGRDRAKLQKAASEIGDKKNTMTIITDITKEAEVLSAIDQTINSFDKIDILVNNAGIINDPVPFHEMTDDQWDDLIKTNLIGTFRMTKAVIPVMIKNGGGSIVNISSVLGIRSIPNVPLSVYGVTKAGVIMFTRSIAVEYGQYKIRCNCIAPSTIRSSIIEPYLQDEGAKKLLESTFPLRKIGEPEDIAGAVAYLCSDDSKWVTGTVMMIDGGISAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I883</accession>
    <name>K0I883_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57481">
        <property type="protein sequence ID" value="AFU57481"/>
        <property type="gene ID" value="Ngar_c05380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05380"/>
    <dbReference type="HOGENOM" id="CLU_1870804_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-536-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="14669" checksum="593C85A6458835C6" modified="2012-11-28" version="1">MGYHTSVSDSAELHSFVKLAIAYLGIMAGLAVLGLGFYVAAARVEFAGDLAVQPERYYTVVTFYVVLVAISLAGLARLVRRKRDGAYLAFAALAISMLAPAPNQVNQAPYAIVWWLAIPNAVVGILLFRSLKTLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8J4</accession>
    <name>K0I8J4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57601">
        <property type="protein sequence ID" value="AFU57601"/>
        <property type="gene ID" value="Ngar_c06580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06580"/>
    <dbReference type="HOGENOM" id="CLU_2406448_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-656-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10561" checksum="9C1E0D297AD7D319" modified="2012-11-28" version="1">MVDMIVLQNGENLIRRDSVELFSDGRRKFGKGMLYLTNTRLMFEMKNGMVPRLVALHTIQSVVPVKKNEFTMSYMNDDGTKISDGVTSEDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8W4</accession>
    <name>K0I8W4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07380"/>
    <dbReference type="EnsemblBacteria" id="AFU57681">
        <property type="protein sequence ID" value="AFU57681"/>
        <property type="gene ID" value="Ngar_c07380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07380"/>
    <dbReference type="HOGENOM" id="CLU_082268_3_0_2"/>
    <dbReference type="OMA" id="YRGTEHV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-736-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="12931" checksum="0B8CB97D20BD0C4E" modified="2012-11-28" version="1">MQLYLQRDMKRVEAIIAAEKVSAVNEALKKAGVGGATILDAKGRGKGEKPQVQTGRGTKRLAAEFSVRANVMTVVEDSEVEKVIKAILDTASTGSAGDGKIFVSTVTEAIDIGTKKRGQTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8W5</accession>
    <name>K0I8W5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57686">
        <property type="protein sequence ID" value="AFU57686"/>
        <property type="gene ID" value="Ngar_c07430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07430"/>
    <dbReference type="HOGENOM" id="CLU_1943923_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-741-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14743" checksum="61501910614246CC" modified="2012-11-28" version="1">MLVVITIRFERKLKSFQTAEHIVLADTPFQDKSYMSDFHLRTWLSKFRQTSIKHLLKMGLFYHSIGFAFGIGETILIEELDPFYETPNLLLTLFDALSAGPIEEALLFGFPFTPLATTTCFLELGVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Y6</accession>
    <name>K0I8Y6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57721">
        <property type="protein sequence ID" value="AFU57721"/>
        <property type="gene ID" value="Ngar_c07790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07790"/>
    <dbReference type="HOGENOM" id="CLU_1811512_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-777-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="15697" checksum="93CFAE60052D0800" modified="2012-11-28" version="1">MTGTAKIVYREAKERGHVSPLSLMSNINLIHANFFFMDIVGLSDPYISTRTQIKKIETLNKSIMECDAFKSTPKEMMLVLPTGDVYGSDLCVERFVQQSVSLGGESAQSNRPVISTAIMYGTNLKSTSNNCHNAGEHEIPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8Z0</accession>
    <name>K0I8Z0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57726">
        <property type="protein sequence ID" value="AFU57726"/>
        <property type="gene ID" value="Ngar_c07840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07840"/>
    <dbReference type="HOGENOM" id="CLU_1954729_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-782-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="15307" checksum="476482069E553B8A" modified="2012-11-28" version="1">MNSNYFVFEGIYSGNHNLEYDTTHLDKPPAPHREIEYYFADQYHPIVFINTSNHAMGPHDNNHDLWKWEYVSWIKEAPIVGEPRHEKRSSGTSNQYFSRQKPEMIIKAEIKDVEHEKVHCIWNSPFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9V0</accession>
    <name>K0I9V0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58106">
        <property type="protein sequence ID" value="AFU58106"/>
        <property type="gene ID" value="Ngar_c11660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11660"/>
    <dbReference type="HOGENOM" id="CLU_1307859_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1164-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_B" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="210" mass="23358" checksum="636CD8A6A90EE2F2" modified="2012-11-28" version="1">MTSDSKIWYALADVIASKLLNRGKVPKIVQAIRFKPVGKQSAMQEINILGKEIDPYKDNLFKVLIEYRKELQQQCTNCNDEGQKVLLDKKQKCIKTIANATCYGIFIEINTKSEESDVAAYGLSTIHCHAGKTEEFGYFSNPLVATFITSGARLVLGAVEAIISKHGASHAFCDTDSMAIPPQYRDSAILQTTEPIWNRYGHVQSRGMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9Y8</accession>
    <name>K0I9Y8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multi_ubiq domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58141">
        <property type="protein sequence ID" value="AFU58141"/>
        <property type="gene ID" value="Ngar_c12010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12010"/>
    <dbReference type="HOGENOM" id="CLU_2299427_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1199-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027802">
        <property type="entry name" value="Multi-ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14452">
        <property type="entry name" value="Multi_ubiq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multi_ubiq" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11623" checksum="18D3274E0B5BF21A" modified="2012-11-28" version="1">MQQLLCLWLSNIKSDELIIFIDGKKIRAPKKILTGEQSLEIANLPPDDHNVYVILEKNKSHQVDIRESIEVQNGMNFVTTRRTCFVIHILIFFSVRILQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAA9</accession>
    <name>K0IAA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58256">
        <property type="protein sequence ID" value="AFU58256"/>
        <property type="gene ID" value="Ngar_c13180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13180"/>
    <dbReference type="HOGENOM" id="CLU_3075475_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1316-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5548" checksum="CF708ADFCE1F6205" modified="2012-11-28" version="1">MAAIIGPLASGIIAERIGLRNILFFAFLATCGSFAMSKGFARQTIVAQKMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAZ7</accession>
    <name>K0IAZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58511">
        <property type="protein sequence ID" value="AFU58511"/>
        <property type="gene ID" value="Ngar_c15780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15780"/>
    <dbReference type="HOGENOM" id="CLU_2629851_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1576-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8801" checksum="E8169B7ED7326ADE" modified="2012-11-28" version="1">MKLRVKITDEKVAIVCPQCGEPIKTVRANKHRTLDETEQELRKAVISLVNEIRFKMYAEREQRAGKQVTTTSEEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBB0</accession>
    <name>K0IBB0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">trpB</name>
        <name evidence="14" type="ordered locus">Ngar_c16630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16630"/>
    <dbReference type="EnsemblBacteria" id="AFU58596">
        <property type="protein sequence ID" value="AFU58596"/>
        <property type="gene ID" value="Ngar_c16630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1638"/>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_2"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="48"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU58596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="401" mass="43786" checksum="2B048163A2A87F2C" modified="2012-11-28" version="1">MGGKFGRYGGKYIPETLAPAVEELESAYEKYRNDPEFQKDLSYYLTEYAGRPTPLYFAKNLTEHIGGARIYLKREDLLHGGAHKTNNTLGQALLAKKMGKKRIIAETGAGQHGVGTAIACAVLGLPAEIYMGAKDVERQRLNVFRMELLGAKVHPVQSGSKTLKDAINEAIRDWIANVKTTYYLIGSVVGPHPYPMMVRDFQSVIGYEIRQQMQELEGRLPDAMVACVGGGSNAMGSFYPFVDDADVMLWGVEAGGEGIKSGKHSATLAAGSEGVLHGMFTYLLQDKCGQVIETHSISAGLDYPGVGPEHAMLKDLNRARYAASTDDEAVEGFLALSRLEGIIPALEPSHAISYAMKLAKEMDKDDIIVVTLSGRGDKDVQVVQDYLDNKGKNKKKKRHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBT0</accession>
    <name>K0IBT0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57015">
        <property type="protein sequence ID" value="AFU57015"/>
        <property type="gene ID" value="Ngar_c00650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00650"/>
    <dbReference type="HOGENOM" id="CLU_2079491_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-65-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13330" checksum="52C054F264AFF225" modified="2012-11-28" version="1">MLKQVICTIKIRRAPRRHDNNVDFKPLVERAAAILPLSVVAADKGYDDEGNHVLVRERMHAYIQCHTATLSRCACMEDAWQVQEADEARLSKSAVQSERNKDETIFSVMKRLFGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICB8</accession>
    <name>K0ICB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57185">
        <property type="protein sequence ID" value="AFU57185"/>
        <property type="gene ID" value="Ngar_c02370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02370"/>
    <dbReference type="HOGENOM" id="CLU_2565861_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-237-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9655" checksum="759CFE504754DBAF" modified="2012-11-28" version="1">MPLGSSDLDQILTDTNLDYAEYRLFICKKEAKFVHADIQDKEFEGRCSSDGSDLMEIEERFPLKCPHCNNDLVIEMIAPLEEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICD0</accession>
    <name>K0ICD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02570"/>
    <dbReference type="EnsemblBacteria" id="AFU57205">
        <property type="protein sequence ID" value="AFU57205"/>
        <property type="gene ID" value="Ngar_c02570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.252"/>
    <dbReference type="HOGENOM" id="CLU_055322_2_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-257-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="22361" checksum="8008B880B429269D" modified="2012-11-28" version="1">MVSAAHGSKGGYILGSIRPGCNGEAVARWVYDIAKRRSDAEFEYVDIKDCNLPLLDEPIPPSQGQYTKEHTKRWAAKVDSFDAFVFVTAEYNHGIPGALKNAIDFLYKEWNNKVAGFVGYVSAGGVRAVEQLRLVMAELQIADVRAQVTLSLFTDFENFTKFKPAAYQQDYVNSMLDQVIAWAGALKPLRTKRPEYSIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICG4</accession>
    <name>K0ICG4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03170</name>
        <name evidence="2" type="ordered locus">Ngar_c03470</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57265">
        <property type="protein sequence ID" value="AFU57265"/>
        <property type="gene ID" value="Ngar_c03170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57295">
        <property type="protein sequence ID" value="AFU57295"/>
        <property type="gene ID" value="Ngar_c03470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03170"/>
    <dbReference type="KEGG" id="nga:Ngar_c03470"/>
    <dbReference type="HOGENOM" id="CLU_1665550_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-317-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="16914" checksum="9F1F42E3BB478F36" modified="2012-11-28" version="1">MKAVASNLESAISLSNILSIVALSDPVAVCRIWTAATGAFFVSRVQLCHCRAVAGVKADPGFSFWHVNSLALLGAFCKAKNDSGDMASIRFVRRAAILPLQAGIFASILRCRHGSRLFVIQRSCYGNRPPCLNPTARSTVNDPIVALALVVEPLTVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICJ2</accession>
    <name>K0ICJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57315">
        <property type="protein sequence ID" value="AFU57315"/>
        <property type="gene ID" value="Ngar_c03670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03670"/>
    <dbReference type="HOGENOM" id="CLU_1559539_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-367-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="18535" checksum="F51CA5BABFE44CB1" modified="2012-11-28" version="1">MGNFVKSPSSGPGTVVGDTHAASLTGNDTHALGNDPSSAGGSSGTGNTINANVYDAWANTVENTAYILAAVTPGGATNLIYVCALVRGYKTANAGTITYRLKENTITLASVTSASLAVNTADSARAIEITLVNQSVAQHTYSITFQGSTSEVRSIFAGGCAKPVTLSGSDTHAASLTGGSGTCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID67</accession>
    <name>K0ID67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57605">
        <property type="protein sequence ID" value="AFU57605"/>
        <property type="gene ID" value="Ngar_c06620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.637"/>
    <dbReference type="HOGENOM" id="CLU_2091375_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-660-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="13562" checksum="5EACC87E3B1D6482" modified="2012-11-28" version="1">MERRRILIDAERIRRLAREEKIGAAVVEKDYALTWLLSGFFLKDSQLKDSFVLKGGTAIRKAFFPGKWRFSEDLDFTVVDRNDANSMSLYRKSWTCFLQRAALPIPYTHTMLTPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID93</accession>
    <name>K0ID93_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative virginiamycin B lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06870"/>
    <dbReference type="EnsemblBacteria" id="AFU57630">
        <property type="protein sequence ID" value="AFU57630"/>
        <property type="gene ID" value="Ngar_c06870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06870"/>
    <dbReference type="HOGENOM" id="CLU_505894_0_0_2"/>
    <dbReference type="OMA" id="ETEYAVI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-685-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="127"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="544" mass="58517" checksum="1F3F3D30DE570C08" modified="2012-11-28" version="1">MVNSLIALLHIQIIAIALLATVFIASAAFATFQISYAQQIPGSFEELVTYEKDSSFIREYPLDVEQPGLRGVTTDSEGNVWAIYSTNKTTTIIRLEPQSGKLTEYHVGGDTQADDAVINLAAGQLTFDRLRNVVWFTDARTNSIGKLDLANNKVDLLQIPNGMAGPMGLALSQDNASLWFTEITGDKIGRVDIESLKITEYLVGQDSGPTLLTFDDKGILWVTLSFSNSILRVDTQALTSGQSSAMTELRLLGEDTFSPFGIAVVDDKVYISDHGSSRIVVADTGFANHQSYWTTPAVAFPASLPSQVVADKYGNIYFPQHGGNRISMIDNATGVMTEYEIPTGPLATAVFIAASDDGKVWFTEWAANKIAYLDTTAKAPFTIGVEKTTVTLDTDTPQSIGVSLNSSVGGTDSVSILQVEIGLTGMTESGLKGVTYEAQPPRVNLQQTGSAESQIQISTLENAIPGDYVAMVRAFAPEQDGLVVSKLYPVELVLDVPEPIASQDSNQPQNADTTLQNALRIGAPLAAAGLIAVAIYRWKRARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID96</accession>
    <name>K0ID96_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57635">
        <property type="protein sequence ID" value="AFU57635"/>
        <property type="gene ID" value="Ngar_c06920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06920"/>
    <dbReference type="HOGENOM" id="CLU_2839483_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-690-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7393" checksum="8320A00350781379" modified="2012-11-28" version="1">MYGTQLLFAMSSKKSWGKQILSRQSQAEYRCRACGKQFEILGDLQTHILLEHHQKGDIPDEAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDH7</accession>
    <name>K0IDH7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rtcA</name>
        <name evidence="8" type="ordered locus">Ngar_c07570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07570"/>
    <dbReference type="EnsemblBacteria" id="AFU57700">
        <property type="protein sequence ID" value="AFU57700"/>
        <property type="gene ID" value="Ngar_c07570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.730"/>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_2"/>
    <dbReference type="OMA" id="PKPGLSH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="6">
        <location>
            <begin position="13"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="7">
        <location>
            <begin position="195"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="352" mass="37781" checksum="ABB1CCF1E19F5735" modified="2012-11-28" version="1">MTEEPVRIDGSQGEGGGQILRTAVSLSGVTGKPVEVTNIRARRQNPGLRPQHMTGIKVIADLFHADVENLKVGAEWIKFAPSERFEGGSVKVDIGTAGSIPMILMAVVPAVSLSGNSLEIEVTGGTDVRASPTIDYVKYVVAEAYRSIGIKFSADVLKRGYYPKGCGIVRSIIEPCRAPGTMELLTTRDVPPKITSVCGQLPRHVAERQISSAMIALEKKGIRCSNYSASIETSVSPGSSILIYSASDFGPFVGGDSIGELGKRAEAVGTEAAERYLESTLAQAPVDPFLADMLVLPLALAKGRSKYRVARATEHLRTNLQVASQMVGCRYRIEQQQKGNNTYVVTIEEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDL9</accession>
    <name>K0IDL9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57780">
        <property type="protein sequence ID" value="AFU57780"/>
        <property type="gene ID" value="Ngar_c08380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08380"/>
    <dbReference type="HOGENOM" id="CLU_2597861_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-836-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8869" checksum="472E1F30A770D3EF" modified="2012-11-28" version="1">MYHHHSLDAEFGSTGDERNAKDSSSTNHKIVRANTGRLSSRLTFRTYGKAGCKGDPKINQNAKLIARWDECSQIPIFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDR6</accession>
    <name>K0IDR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59531">
        <property type="protein sequence ID" value="AFU59531"/>
        <property type="gene ID" value="Ngar_c26090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26090"/>
    <dbReference type="HOGENOM" id="CLU_194244_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2609-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9635" checksum="C003F03D5A1B9402" modified="2012-11-28" version="1">MTETATTKQSGLLEDSTFNIISQLEKKADFLYSSVEKYMRDAEKDNKPELAKLWSTIKEDEQKHLQMLREELVREAKQDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDT0</accession>
    <name>K0IDT0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57885">
        <property type="protein sequence ID" value="AFU57885"/>
        <property type="gene ID" value="Ngar_c09430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09430"/>
    <dbReference type="HOGENOM" id="CLU_2662484_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-941-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8444" checksum="8C62DD7E2C6428F6" modified="2012-11-28" version="1">MRAYFHLAYRQAEGVVKAHAKKKVPSIPDYSTISRRVNKLDIDVDEHVGNDIVIAWTAQESRYPTVVNGCTINGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE01</accession>
    <name>K0IE01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c00980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57048">
        <property type="protein sequence ID" value="AFU57048"/>
        <property type="gene ID" value="Ngar_c00980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00980"/>
    <dbReference type="HOGENOM" id="CLU_2103580_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-98-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="13368" checksum="F9ED138AD5260CFD" modified="2012-11-28" version="1">MMCGSGVKVLWQIRKEKTRISQLLHHISKAIVESAKENKIAIVKTFVVSAIYTSEAITKAESISYRSRLNGWSFAEIKRQIEYKARWKGVYQQFNYYQLKKPEAHLSSVHHAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE10</accession>
    <name>K0IE10_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb3</name>
        <name evidence="7" type="ordered locus">Ngar_c10580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10580"/>
    <dbReference type="EnsemblBacteria" id="AFU58000">
        <property type="protein sequence ID" value="AFU58000"/>
        <property type="gene ID" value="Ngar_c10580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1006"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="TKMMHDK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="6">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="6">
        <location>
            <begin position="183"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="269" mass="29820" checksum="36E4286CE5E50960" modified="2012-11-28" version="1">MLSDKAQESRPEWRAFTGEEANDRSRTGIPSSLARHDMGLSTVIGRTDKDASGRAIDVAMRSTMGRLRAWDFRTQAHSPTDRNLRQAFSELDRLKDKLGVSDAVIEKTAYIYRKAQERGLVRGRTISAMVGAALYIACRETGASRTLKDIAEIGNIKRKDLARIYRLVVMELDLKIPMIDPMKCIVRVANRANLSERTKRVAMNIMKGVTKSGISAGKDPMGLAASVLYLACLNTGESRTQTDIAEAAGVTEVTVRNRYKNLKSQLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEE7</accession>
    <name>K0IEE7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58145">
        <property type="protein sequence ID" value="AFU58145"/>
        <property type="gene ID" value="Ngar_c12050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12050"/>
    <dbReference type="HOGENOM" id="CLU_082168_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1203-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="26426" checksum="E53373919FAEF3EA" modified="2012-11-28" version="1">MEMLVDLQNRKEKYGYDNKSESYFNAEQNAIVAKNAEMYYRALMRGGSISWNIRDYHMAEALQKLVKFHGKGAKSIIWAHNMHIGDARATSMTRAGMINIGQLVREWAGSKQTVLVGFGTHRGSVIAAREWGEPMERMLVPPAAEGSWDDLIWRLAGKNSLLIFPDAGIPAVTMGQRAIGVVYDPEYEKYGNYVDTVLPSRYDAFIHVGETHALHPLHMRVSPDEELPETFPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEJ5</accession>
    <name>K0IEJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59771">
        <property type="protein sequence ID" value="AFU59771"/>
        <property type="gene ID" value="Ngar_c28510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28510"/>
    <dbReference type="HOGENOM" id="CLU_2565861_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2851-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9247" checksum="BC1321532E4FB9E4" modified="2012-11-28" version="1">MDQILTDVNTEFAQYRLFVCKKEKKFVHADMLDVHFDGKCPSDGTDLEEVQDPRQTKCPRCGKELEIEEIKPLATADTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEK3</accession>
    <name>K0IEK3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UPF0142 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02500"/>
    <dbReference type="EnsemblBacteria" id="AFU57198">
        <property type="protein sequence ID" value="AFU57198"/>
        <property type="gene ID" value="Ngar_c02500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02500"/>
    <dbReference type="HOGENOM" id="CLU_056369_0_0_2"/>
    <dbReference type="OMA" id="CHLHPEI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-250-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="69"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="441" mass="49251" checksum="3C855595A544B06A" modified="2012-11-28" version="1">MQLQSRKKWTVNGTSRIRPAQETLEKVVPISKRIGVTRLADITDMDVLRIPNYSAVVPGTEDYIWVYSGKGPTREHAMASALMESIERYSSLPSSGGPRNFIRSSYAELSKIHKVLHPDSIVEPVRFEYRDDMLMDWLPGYDVISGEQVMVPASIALFRYTPPPPAVNPFAYFHTNGLASGNVVEEAICHALCEVIERDAMSLAELRASAIPFHILRTVHHSLNSAGICVPPIPADRFVDDPSVFPDVDISEIDFEPARNLADRFSRAGISLTIKDITSDIGIPTFNASSVEWVTHDYGYLAEGHGTHPDARIALLRAITEVSQTRAANIQGARDDLRKIKYSEQNTDDQRAWQFMPSTKRIKFSQVQTFFNEDILDDIKLILSRLKSVGLTQAIIVDLTNPDIGIPVVRAIVPGLETFKITKSVMGMRARACFGQWKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEL7</accession>
    <name>K0IEL7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="8">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gatB</name>
        <name evidence="10" type="ordered locus">Ngar_c02700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02700"/>
    <dbReference type="EnsemblBacteria" id="AFU57218">
        <property type="protein sequence ID" value="AFU57218"/>
        <property type="gene ID" value="Ngar_c02700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02700"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.264"/>
    <dbReference type="HOGENOM" id="CLU_019240_0_1_2"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="9">
        <location>
            <begin position="325"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="481" mass="53565" checksum="014409F8E7755E74" modified="2012-11-28" version="1">METKIGLEIHCQLTGAKSKLFCRCSSDYRGKAPNANTCPTCSGLPGTLPLLNQKAVEFAGMISLALGCKIPDEIAFYRKNYFYPDMPKNFQLTQYNAYGITSIGVEGRLGYGDGKSARIRRVQLEEDPGRLVYEGGSMETSVYALIDYNRAGVPLVEIVTEPDFTDPKDVRMFLDKITSIIEHLGVCDTKLEGSVRCDANVSVGGGNRVEIKNVSSFADVEKAVRYEITRQRTMASRDIEVRSETRHWDDARKVTKESRTKEEEQDYRYFPEPDVPAVVLGSEFISSIRQSMPELPDTRKDRFVSKYGISSHVAQVLIDNKELADFFESAIKIYSSPKEIANWLVTDLMSFVDERQKEEQQRRSLFAGLKIGPEHIADLAKLVDQGTINRATAKQILAQVVRTGEMPSHVAKKTQAAKIDDVGALAQAIESVFKSEQAAVQDAKRNPNAANFLLGKVMQATKGRADPKAALEMIQKKLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP7</accession>
    <name>K0IEP7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5678 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c03100</name>
        <name evidence="4" type="ordered locus">Ngar_c03400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Enrichment culture Ga9.2</strain>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57258">
        <property type="protein sequence ID" value="AFU57258"/>
        <property type="gene ID" value="Ngar_c03100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57288">
        <property type="protein sequence ID" value="AFU57288"/>
        <property type="gene ID" value="Ngar_c03400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03100"/>
    <dbReference type="KEGG" id="nga:Ngar_c03400"/>
    <dbReference type="HOGENOM" id="CLU_1998814_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-310-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043734">
        <property type="entry name" value="DUF5678"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18929">
        <property type="entry name" value="DUF5678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="DUF5678" evidence="2">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="13792" checksum="DB5B465BC00E54BA" modified="2012-11-28" version="1">MGNHSDKWTSITVSRDVYKALEKTKKNGETFNDVVASMVAEKERSKKQESELDWLVRQGPDFLVPYAGKYIAIWKHEIIGVGRHEGEALDAARKKVPDSNPTIMGVPTQEGFIGGFKIAKTANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEQ0</accession>
    <name>K0IEQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03150</name>
        <name evidence="3" type="ordered locus">Ngar_c03450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57263">
        <property type="protein sequence ID" value="AFU57263"/>
        <property type="gene ID" value="Ngar_c03150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57293">
        <property type="protein sequence ID" value="AFU57293"/>
        <property type="gene ID" value="Ngar_c03450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03150"/>
    <dbReference type="KEGG" id="nga:Ngar_c03450"/>
    <dbReference type="HOGENOM" id="CLU_1048141_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-315-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="265" mass="30152" checksum="97CB60B68089720C" modified="2012-11-28" version="1">MARAFSIRIGDAFADFLETLGDKRKAIENALDLKRKFDAGQLVEVNTLLKGQESDACIFGLKDVDPLSNVADTNCPIKKIYPALKKAENGEELAKFCAKCPWRDHDKVVYKLKTRYTNLFREALENAEVQTIVSVPTTDTPQERHEAATTTMVKATTRVSAKKEGWQSTCYRCGQTVYYHKSVKSSSGKHIPLDNLEERKTHDCPNYEPKLRTQAPVSTTRQEKRWEPRYCDCGIKYTDKSEMAAHVKTVHNRNLTPYEAQEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEZ0</accession>
    <name>K0IEZ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ahcY1</name>
        <name evidence="4" type="synonym">ahcY</name>
        <name evidence="8" type="ordered locus">Ngar_c14030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14030"/>
    <dbReference type="EnsemblBacteria" id="AFU58340">
        <property type="protein sequence ID" value="AFU58340"/>
        <property type="gene ID" value="Ngar_c14030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1366"/>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="182"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="211"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="290"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="415" mass="44619" checksum="A793401EAC646B88" modified="2012-11-28" version="1">MEFRVKDLALAEEGKNRIDWAEAHMPVLVALRQKYEKTKPLKGIRVAGCLHVTKETGVLVRTLKAAGAELSWCGCNPLSTQDDVAASLAKDEGIAIFASRGVTSKEYYDDIHSAMKLDPHVTIDDGADLTVEMHKGMPKSIRGGTEETTTGVIRLRAMQKAGKLAYPIIAVNDAETKHDFDNIYGTGQSALDGIIRATNILVSGKNVVIAGYGHVGKGVARRAAGLGANVIVTEVDPIAALKAKLDGYSVAKMNKAAEIGDIFVTTTGCKDVIVDRDIAKMKDGAILANAGHFNVEISIPGIESQTVQKKEINDHTMQYSLKNGKRVYLIGEGRLVNLAAAEGHPSEVMDMSFANQFLAVLKLAQQGQTMKPLVYNIDKAQDQEIALAKLQSMGVEIDSLTPAQKAYLEGFAEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF02</accession>
    <name>K0IF02_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57378">
        <property type="protein sequence ID" value="AFU57378"/>
        <property type="gene ID" value="Ngar_c04310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04310"/>
    <dbReference type="HOGENOM" id="CLU_3210873_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-430-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="44" mass="5011" checksum="F7C48BBF186DDA13" modified="2012-11-28" version="1">MIVDDESDILYVLKPGIEKNLGCSVSTFSDPLQALKYFREPQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFJ5</accession>
    <name>K0IFJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60136">
        <property type="protein sequence ID" value="AFU60136"/>
        <property type="gene ID" value="Ngar_c32200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32200"/>
    <dbReference type="HOGENOM" id="CLU_1052177_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3220-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="267" mass="30996" checksum="AAEF3506222F170E" modified="2012-11-28" version="1">MPFNVEDLRKARQALAQFKSAAVSPYHERYIFPFFAGSYFAYRKVDVLRVVAITRAISNNPSYLDVGCGYGDFLKHVREFLPDAEGMEKEGGIFYGLGIEKPEYIRIADAHWIDRKYDLVFVGWMEPGQDFRDPVARNTDVIITTLDQGISLAAEFDGHGFQRVAWWRTPSWEDVNTEIMNRYYTKMPDSKRIELAKMRGAHNFWYIYSRPHKAGIVKKALKKQLEKEQQPADCYEFESVLDECGYGYLQKLENPAAPELMWQVQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFK0</accession>
    <name>K0IFK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32250"/>
    <dbReference type="EnsemblBacteria" id="AFU60141">
        <property type="protein sequence ID" value="AFU60141"/>
        <property type="gene ID" value="Ngar_c32250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32250"/>
    <dbReference type="HOGENOM" id="CLU_140794_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3225-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="18178" checksum="49A0287B077CBA40" modified="2012-11-28" version="1">MTKLIQAMPGMSEPVTEADVARLLESRLNLQLATLDEEGYPNIAPVMFYYDKDSGKMYVNADKRSRKVQNIRRNPDKIYYSIDDENYFYEGVKGRARATIIEDTQKNISILEKINLKYLGTLKHPVARELMENTRSGTYGTIEITPKFFSAWNLGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFL2</accession>
    <name>K0IFL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32350"/>
    <dbReference type="EnsemblBacteria" id="AFU60151">
        <property type="protein sequence ID" value="AFU60151"/>
        <property type="gene ID" value="Ngar_c32350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32350"/>
    <dbReference type="HOGENOM" id="CLU_684461_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3235-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="412" mass="44647" checksum="DF074461F6E76F4A" modified="2012-11-28" version="1">MAGGYTKVIAIAAVAVSAALLVSIFVVVPFFTLVGSANNDASGGLRIVTIAQPYADEPVFRNVKASDSGMQASSMQWVVDPFGRSMRTFHENRINSSSSEDAKRAWIGSIDAQEKYVLVRLPEWLGGSKNDLSSYRVFSAFDIMSQCNIRYWDTRMLIEDPCHGNGYRPWDGLVVQGIASFGASGSNAGLFSSSILALPQMRLGVDSEGYIVAYRLDNSLNGDGVVGEGRRFAPEQLEQSNKKMIEVVSEYAGFELPLPTMVSGGHHLVWLAPETMGIDLFPGQSFEGYEGTFSAVYQPRPLQEGYSSYRITIFLDEKLVVDDASQAKATFDKLFGTTASPECEQGCRYIVKSNDNAIARADTEGEENGTLYAAALAWGKSDGRDIMVAIEGINSSAEELLSIAESLGIAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFS3</accession>
    <name>K0IFS3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23p</name>
        <name evidence="4" type="synonym">rpl23</name>
        <name evidence="6" type="ordered locus">Ngar_c17320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17320"/>
    <dbReference type="EnsemblBacteria" id="AFU58665">
        <property type="protein sequence ID" value="AFU58665"/>
        <property type="gene ID" value="Ngar_c17320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17320"/>
    <dbReference type="HOGENOM" id="CLU_037562_4_1_2"/>
    <dbReference type="OMA" id="KAMMLLD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13213" checksum="E254552585BE3671" modified="2012-11-28" version="1">MSKETTTKAAASAAEPKKEAPKKEANATAAPTISMTAEEATSLIIAPYVTEKTFNQIEKENKLAFIVAEKASKKEIIEAIQILYEAEATEVNTTRTIRGKKAFVRFKAPEGARDLATKLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG00</accession>
    <name>K0IG00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c34160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60331">
        <property type="protein sequence ID" value="AFU60331"/>
        <property type="gene ID" value="Ngar_c34160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34160"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="CGRINEK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3417-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="168"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU60331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="391" mass="46209" checksum="6190B310ED96B1AF" modified="2012-11-28" version="1">MRNFRFRLYPTKEQESKLRNSLGASRWLYNYFVSKGNLPIQDTQFMLTELKEEEAWLRNYHSKMLQMVVHKIDSNRKVLNALRMNGYKIGKMNFIGEEDYNSFTYSQSGFRIERHGNTDLLWLSKIGYIEIRLHRHPTNIKQITIVRRINKWYALICCEIAKPIFRFINPKKSVGMDVGITKFLHDSNNSTIDNPLFVKKMLKSLRRAQRRLSRRHKYSKNRLKAKTRLQILHERIRNKRLDFLHKVSTRYSKNYDVIFLERLRVSSMVKNYHLARNIIDSGWSTFKNILAYKTKLVIEVPSNNTSVNCSKCGNKVPKSLAVRIHKCNVCNLMIDRDYNASLNIKKKGLLLLLPQGLWEATPVEILSESVKQEQNIVQRIVVHYRSIEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG44</accession>
    <name>K0IG44_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08410"/>
    <dbReference type="EnsemblBacteria" id="AFU57783">
        <property type="protein sequence ID" value="AFU57783"/>
        <property type="gene ID" value="Ngar_c08410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08410"/>
    <dbReference type="HOGENOM" id="CLU_2392984_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-839-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10773" checksum="8F7ED63E95B00305" modified="2012-11-28" version="1">MEHFSSNPITYDLIISDIRMPKMNGFELCKEIRKLDGKVKICFMTAFEMHLKEFETILPSIRVDGLITKPVRIVDLCSTVKRLLAIAEREDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG81</accession>
    <name>K0IG81_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58800">
        <property type="protein sequence ID" value="AFU58800"/>
        <property type="gene ID" value="Ngar_c18680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18680"/>
    <dbReference type="HOGENOM" id="CLU_2447764_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1866-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="10198" checksum="AF3A59291C3ECD77" modified="2012-11-28" version="1">MGKKVHYYRVKYLYGDAFQNILAVVLKELAVMLYADQVRTSHIYLVHPLVSDAAVLPYAQTRLILTGFVFVYAYKVGCVRVDTFKACNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG96</accession>
    <name>K0IG96_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60426">
        <property type="protein sequence ID" value="AFU60426"/>
        <property type="gene ID" value="Ngar_c35130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35130"/>
    <dbReference type="HOGENOM" id="CLU_2519883_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3514-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9113" checksum="96D59BEA3C7F9CC9" modified="2012-11-28" version="1">MYKTDIAKALERSLGMLGEPSKKALLFHLTHTYKIPVDKKDCCPLEEIKGALRQILGEGASLVVASINKELAKQSERGAGTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGA1</accession>
    <name>K0IGA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57848">
        <property type="protein sequence ID" value="AFU57848"/>
        <property type="gene ID" value="Ngar_c09060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09060"/>
    <dbReference type="HOGENOM" id="CLU_1567207_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-904-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="19675" checksum="38980C0B0D27DA7A" modified="2012-11-28" version="1">MSIKLTFGRLVLLRNKPVQRLAVRKYESILFSILHLIGCIRWPAPSVRKRGHPYVYSPTVILRCFIVRIWFLIDSNNALHEFLVSDSAYSRKLIAACGLKSIPDRRTFDRRLRTMPSDVKQRIAAMGRLFVSERLVDSYIVAPDSTLLRAKSRRVWHKSSMKKGEVHILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGI1</accession>
    <name>K0IGI1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57943">
        <property type="protein sequence ID" value="AFU57943"/>
        <property type="gene ID" value="Ngar_c10010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10010"/>
    <dbReference type="HOGENOM" id="CLU_3323102_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-999-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="40" mass="4865" checksum="3B7DA46519F7CE81" modified="2012-11-28" version="1">MRINSKTAIPLLSEKIIVLKRMRIRRRRGRKKKEDNNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGJ7</accession>
    <name>K0IGJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type IV pilus assembly ATPase of Type II secretion system protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19930"/>
    <dbReference type="EnsemblBacteria" id="AFU58925">
        <property type="protein sequence ID" value="AFU58925"/>
        <property type="gene ID" value="Ngar_c19930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19930"/>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="THEYTYN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1991-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="258"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="516" mass="58446" checksum="71D51B327E91A9B3" modified="2012-11-28" version="1">MARAPKPLNQSPKFRAEPLVAVVSGEILDRYAVEQAAVYVVLDKNDGGGKARYIVTEPTLDEEEQRVYSLIMEGLYFSLKPIAKAEDPLQYIEGYIWEVAENLGLVQHLEKAYQKYRYFIARDAIGYGPIDILMKDNDVEEISSEGYDKPVAVMHRRFTEYDWIDTNVRFASEDSLRKYVQRLAQKTGKSVTVAVPFADSMTSDGHRVAVTFAGEVTLPGSSFDIRKFPKEPLSIAHLIKSNTMSALMAAYYWLLVESKGFVMILGTMGSGKTTTLNSLSTMINPSSKIATIEDTPELRLPHTHWQRFKTRRTYSITESRFDVDLMDLVILSLRYRPDYVILGEVRGAEIRALIQAAAIGHSALCTMHAESPEAALVRMSSPPMDVSLGGRMLVWNFLMLNRVKDRQGGKVIRRTISSTEVIPRENLVELKQVFAWNPRTDRFVPDGDNAAKHLVETSYRLKEIAKLRGWTDDELVAQLEERRVLLASLVEEDRLSYSDVSEAIQSYYHRNNVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGU7</accession>
    <name>K0IGU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21400"/>
    <dbReference type="EnsemblBacteria" id="AFU59070">
        <property type="protein sequence ID" value="AFU59070"/>
        <property type="gene ID" value="Ngar_c21400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21400"/>
    <dbReference type="HOGENOM" id="CLU_747259_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2138-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="370" mass="41865" checksum="20D527B440629433" modified="2012-11-28" version="1">MSAGAPAKDRGINIAIQEGAKVRHEWKTKFKHKALPSAADSVVFNNFLNSIKTVKTLELYHKGLHNLMKDAGITSYEYLATAPASKIEQEVINFIARRVAKSPSITGNGIYNYTKLLRLLLNQNKRKDIDWERIGRVTPEYNSTADDEAYYIDQVRLAFEFAKIRGKVTIGLMSGSGMRRGGFVGLNFRHLVTSPRLDRYCIFKVRVHADTEYHTFTTPETRRLIEIYWEQRIRDGEPVSLDSPVIRDAYNPEEPDSVKNVVPANENMISHMMIRILQGCGLRVNIPSDLENGTYAGSIRHEKAGSRLSQVLRDDLHRLGTLRDLHAPFAGSQVKGLENKLLPTKRRRLHSGRKRGCQGLCADDIVSDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH26</accession>
    <name>K0IH26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57117">
        <property type="protein sequence ID" value="AFU57117"/>
        <property type="gene ID" value="Ngar_c01680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01680"/>
    <dbReference type="HOGENOM" id="CLU_2629843_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-168-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8927" checksum="3DC835E975979CB9" modified="2012-11-28" version="1">MLVSCMDFKLVLIREACIADRAYTCLPPFTSLSLRAAEAIQLAMPHYVGYIVLKNLSFEMSLLAGRMYFIKYYHEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHC0</accession>
    <name>K0IHC0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58293">
        <property type="protein sequence ID" value="AFU58293"/>
        <property type="gene ID" value="Ngar_c13550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13550"/>
    <dbReference type="HOGENOM" id="CLU_1850703_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1353-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15715" checksum="B9934ADF254F2A95" modified="2012-11-28" version="1">MVVTTSTIDATAAPVIITRTEVSESDVVSEPGDLFTLRYNRIKEEARAEVARAYKITARPAMTTNLRHGQVGPCVWCGAVATLEILLHYRSHLAEEWRHIWTVNNDGWFTWIVVEKHCDSCARRHYPETMTTSLEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHC2</accession>
    <name>K0IHC2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59325">
        <property type="protein sequence ID" value="AFU59325"/>
        <property type="gene ID" value="Ngar_c24000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24000"/>
    <dbReference type="HOGENOM" id="CLU_096705_1_0_2"/>
    <dbReference type="OMA" id="GYLMEWG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2398-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007366">
        <property type="entry name" value="DUF432"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04254">
        <property type="entry name" value="DUF432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="28062" checksum="88C4769EFCCE3163" modified="2012-11-28" version="1">MEELFGQHRLQSKATKDYQLVFGENRIEISSVGSSLSYRRYAGNELATEAMIVSNEDPVIIGVFPNTPLFTPAAVAKNVYLKFKTPVVVDQRSRVVIYAKMPIEIGVYRQSKDEEMLIDSFSRGRQQYALYGSPESGVVCRYMETEVSTNIDDIRPAKYEEALVRIGIKNDIDNVIKVSKLIIPMDSVILDHAHDDSWLPGTVEMDLSTSFGKDIVHVRLANTKVKRSDKTSIKAKKEETLVFLMDAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHG6</accession>
    <name>K0IHG6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58348">
        <property type="protein sequence ID" value="AFU58348"/>
        <property type="gene ID" value="Ngar_c14120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14120"/>
    <dbReference type="HOGENOM" id="CLU_2152693_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1410-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="12052" checksum="72CE3E24297B4B75" modified="2012-11-28" version="1">MLEELARAEDKQERMNVFRRYFAASRYNRLLIQQTLVRSAQDGSLLSKVKKMEQAHDKGFVDTVKALKKNGYFDEFLAAVKEEDEALVKIIEAYDKRMRSNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHI8</accession>
    <name>K0IHI8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58363">
        <property type="protein sequence ID" value="AFU58363"/>
        <property type="gene ID" value="Ngar_c14270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14270"/>
    <dbReference type="HOGENOM" id="CLU_2032936_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1425-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="12791" checksum="C262955D6A977371" modified="2012-11-28" version="1">MQNQGISTYHVTMDDSDKLGVKPEVLVSMYTAIDAKARQLAPQDFKRELVISQDGRIKSRFYIRVSNRMAPHLIAAIQQQADSESGIGMKSYFYKLQEQLMSQMFTGVKDVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX8</accession>
    <name>K0IHX8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57517">
        <property type="protein sequence ID" value="AFU57517"/>
        <property type="gene ID" value="Ngar_c05740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05740"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-572-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14221" checksum="487F5BFA2DF6B81F" modified="2012-11-28" version="1">MADYQKMCDEVLHLDRSIRYVGLADHLGSLIATVYKPGLVPLSTKEETEAYTIQAIQRMGVIQGGPKVGRLKYVVGRFENLIRATIPVVSAGHDKFYLMLSMDLASDPIKVIENKVLPRVEKSMMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0II84</accession>
    <name>K0II84_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07390"/>
    <dbReference type="EnsemblBacteria" id="AFU57682">
        <property type="protein sequence ID" value="AFU57682"/>
        <property type="gene ID" value="Ngar_c07390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07390"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.714"/>
    <dbReference type="HOGENOM" id="CLU_571898_0_0_2"/>
    <dbReference type="OMA" id="TWNINEL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-737-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="167"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="477" mass="53555" checksum="DC61B6C0BC94754A" modified="2012-11-28" version="1">MKILSKNANELLLLAMKEDSAAKGDYLLIEDRSRSMIVQVYDEEYLSSQALIEDIVKEEVVNASSVENLHDPLNIGSLSRLVRDARIFRAKIRASVKDGKLSSDVTWLPSRVESKIRRLAMKELDSFLGRRGIFPIPLGRTGDSEEFEIYAEDLDGKLTIITGKKESGKSHLSKMLVKTLVQHGAFVVIFDLNNEYSGLGWNRDGTPSAIHRQVKVLEPGKTLRFTLNYCGKGAVSGMLKNALDMPAASLREFFRIWDWLENKQSLSIDAIGNAVNTWNINELVRDALVSRYHVIQSSRLFGDSGLRFEDVISAGGGGAALVINMGEVSPTVRRMVVELVLSKLVDLLERQIIPPIFLFAEEAHLYIRDTYWEDIITRMRHFGVYTTFITNQPDAISDSIYRQVDNIFLFNFTNDGDLEKIARVSLADSDTIRSIVRTLPQRHCLAIGKAVCDLPVVVRVAAAEVLTLGETKKFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM3</accession>
    <name>K0IIM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58913">
        <property type="protein sequence ID" value="AFU58913"/>
        <property type="gene ID" value="Ngar_c19810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19810"/>
    <dbReference type="HOGENOM" id="CLU_1248317_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1979-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="221" mass="23307" checksum="94158CFD68A01EB7" modified="2012-11-28" version="1">MASNAIVASIGIAIGIAIGVGAGLAILASVAPGLEKQVQEQNSRITALESELQLANEKNAALENGLDRGRSMQSMNSAASVTVPPVMGFYSGQEILFIHTEASDQSVASMLTMMMGSPVIFVPSLKDVPLSSLGEVYVFTNGVAGNGPFGFQPDVFSSVPTDRDYTPLRTVKLVSWNDPSAARELHSVEEVKDAEAKGEMTVSNPGVVVNMPIVKWQGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV1</accession>
    <name>K0IIV1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11050"/>
    <dbReference type="EnsemblBacteria" id="AFU58047">
        <property type="protein sequence ID" value="AFU58047"/>
        <property type="gene ID" value="Ngar_c11050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11050"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1047"/>
    <dbReference type="HOGENOM" id="CLU_078701_0_0_2"/>
    <dbReference type="OMA" id="PKSHPRY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1103-MON"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="PTHR40695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="26945" checksum="6FDA67185525555C" modified="2012-11-28" version="1">MHVNRISIPPNHPRAKSLHTREALVDGYRRGLVVAEGLIAHGRGEAYDYLIGECTTKTAQRAIKAAAAMLLLSRHPVISVNGNAAALCPGAIVELAKATGAAIEINLFYRTEERERAIKAELETHGAENVLGVGSRASATIPELQSERRRVDPDGIYSADTVFVPLEDGDRTEALVKMGKKVITIDLNPLSRTAKAAHITIVDNIVRAMPALAEAAHQLNGSKSLKRIVDGFDNKKNLRESLKIIRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ02</accession>
    <name>K0IJ02_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59078">
        <property type="protein sequence ID" value="AFU59078"/>
        <property type="gene ID" value="Ngar_c21480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21480"/>
    <dbReference type="HOGENOM" id="CLU_798369_0_0_2"/>
    <dbReference type="OMA" id="RENEHIE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2146-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="347" mass="38406" checksum="353DC63E2D52446A" modified="2012-11-28" version="1">MIATQFLSLVPFQAHASGSTNNDDIAFDLQKAQSYILSQYDPSLGLVRENEHIEKYWLWSDNELAAAALRGYTPNISENITKSILNYMGDYGAFRSAYGAILGKDTSFLAPLNKNVTDKVWYTDFSTGNTELQCADYADIAFLKAIHYYKIGDYAQSTECYLAGQRMFDGTGFKDRAYAADDNRYSTYKVALWKIAAELARGGDEDVIVAGKADEILTKLQDAETGGVYTHYRSGFVQDSQTNVETTSLAIFAFDTSLLQPKLAPPTPEMLEECKELGIEEEKCSEQAIMTEQSRRVNTPSGTQIELLGNPSMLVMFGLLAAGIGSGAVVFYVKSRNAKEKSRGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ07</accession>
    <name>K0IJ07_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp20</name>
        <name evidence="4" type="ordered locus">Ngar_c30690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59985">
        <property type="protein sequence ID" value="AFU59985"/>
        <property type="gene ID" value="Ngar_c30690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30690"/>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="OMA" id="EPIAEMY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="95"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="191" mass="21423" checksum="4146733E39C99C49" modified="2012-11-28" version="1">MGSRRWSPWGASTTGSMFREFEDMRRDIERMFEETIQDIGRVPKELVREYETPSGKVREVGPLVYGYTATIGPDGKPKIREFGNVRPSLGAAATPMLSSELEPLADVITSDKEVKVTIDMPGVSKQDIKISAYDSTVEVSTVENAKRRYYKVVELPPETDIETAKSTFTNGILEITFNKKAKPKGREIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ14</accession>
    <name>K0IJ14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59093">
        <property type="protein sequence ID" value="AFU59093"/>
        <property type="gene ID" value="Ngar_c21630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21630"/>
    <dbReference type="HOGENOM" id="CLU_2243947_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2161-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11553" checksum="71F6204B751316EC" modified="2012-11-28" version="1">MSESKPDKIEFKMLDYSTIDGDTVSFKLEDGTIVKVKVGIERVGVATNYRNPDGSLHYAVNTSVKVYVIPHDKRFTLPRSQVKGQAPLQQDDSSSGKRPPSHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ65</accession>
    <name>K0IJ65_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58247">
        <property type="protein sequence ID" value="AFU58247"/>
        <property type="gene ID" value="Ngar_c13090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13090"/>
    <dbReference type="HOGENOM" id="CLU_117488_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1307-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="190" mass="20328" checksum="158F9AFBBA8D3C7F" modified="2012-11-28" version="1">MLLQSWRFVKYSGVKYGAIAGIIATWSISTTIAASEVELGLPMSTFYSVMGMSFGYEDFVAAAYLGFGLHLVTGTALGAVIGLASVKWIRIMINPYKAVMAGIVAGIAVWLVLFLPVTVLLVQPSIQHIVSLLPEDTQGILSGNSQFIAGIVSSAIVFHMVWGAIFGYISSSLMRIMAFRTSHAVGGMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ73</accession>
    <name>K0IJ73_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58272">
        <property type="protein sequence ID" value="AFU58272"/>
        <property type="gene ID" value="Ngar_c13340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13340"/>
    <dbReference type="HOGENOM" id="CLU_2646045_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1332-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8641" checksum="67CEF0AD64724C45" modified="2012-11-28" version="1">MDGGPTWSNRNTRSLGEVYAGEELEVKYIVSEKKEDKGYGILAIDFEISMVRDKKLVIVSHKNLYRIKRLSPGSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL9</accession>
    <name>K0IJL9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33200"/>
    <dbReference type="EnsemblBacteria" id="AFU60235">
        <property type="protein sequence ID" value="AFU60235"/>
        <property type="gene ID" value="Ngar_c33200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33200"/>
    <dbReference type="HOGENOM" id="CLU_173008_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3320-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="12807" checksum="DACCAFB488742F82" modified="2012-11-28" version="1">MLDYRMPKKDGIEVAKEILNLNADQRIIFASAYVKDTLVDSVKQLRRAVELMQKPFKIEALIDTLEDKEIYEELKKLNVDADAFKAVNATHDQITKLLEAIRRLQKNRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ0</accession>
    <name>K0IJQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58507">
        <property type="protein sequence ID" value="AFU58507"/>
        <property type="gene ID" value="Ngar_c15740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15740"/>
    <dbReference type="HOGENOM" id="CLU_1412404_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1572-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="192" mass="21620" checksum="76362845E44CF85B" modified="2012-11-28" version="1">MTLQRLFDAVQESAQVIGRRGMLSTVAPTMLLLVTETFVNEPPPMSLLTAEEFSNEPPAMSLLVTDGFENDAPPMSLLVASQFNGYSWIPNVLIDCRKDNAIFGAHINVEITYEQEISAGVWQQLRFTPFGTLLETSYPARQHRATVPATYVEFSEAEQKNIIYDAVSTSLTFHPSYTEKTEFVFVYIRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJS2</accession>
    <name>K0IJS2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60330">
        <property type="protein sequence ID" value="AFU60330"/>
        <property type="gene ID" value="Ngar_c34150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34150"/>
    <dbReference type="HOGENOM" id="CLU_2646048_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3416-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8537" checksum="91CAEDF02691BE8B" modified="2012-11-28" version="1">MIAKSAAQKEIAGGKFAMHLGDRIQHVEILSEKTVCGLSLNVGWTNRFGEINDILRVHQFAWLAKGKDSRWIKMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK04</accession>
    <name>K0IK04_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HVO_2753_ZBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26360"/>
    <dbReference type="EnsemblBacteria" id="AFU59558">
        <property type="protein sequence ID" value="AFU59558"/>
        <property type="gene ID" value="Ngar_c26360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26360"/>
    <dbReference type="HOGENOM" id="CLU_196471_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2636-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6779" checksum="494ED6E38CC203B5" modified="2012-11-28" version="1">MYAGSYDMPNCNACGKEVRPGELSESFSCPKCRNARIWRCEGCKGKQKKYRCTACGYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK06</accession>
    <name>K0IK06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58617">
        <property type="protein sequence ID" value="AFU58617"/>
        <property type="gene ID" value="Ngar_c16840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16840"/>
    <dbReference type="HOGENOM" id="CLU_1425129_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1682-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="190" mass="20206" checksum="FEFF750EC6947A45" modified="2012-11-28" version="1">MVEGLPVCGFNITLRLLPLPLPPLPSLSLLLPELVETVIDAVAAVLLLAPSFTPKVKLSVLEKPAFGVQVRLGVVPERVPLKGPDTTENCSDTAAKLGWASGFMPLSVNATALSSFIEIDAVVATGAQASARALPLVTDPVNIQLHWMILMLPSLSMVPVVDIILRFMPELTVSESAEPSDRMPSLSAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKB2</accession>
    <name>K0IKB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58787">
        <property type="protein sequence ID" value="AFU58787"/>
        <property type="gene ID" value="Ngar_c18550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18550"/>
    <dbReference type="HOGENOM" id="CLU_2730544_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1853-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8273" checksum="07E8BE0D3DE975F0" modified="2012-11-28" version="1">MKKDDPRVANQVVVTSFQIRLFLYYERASFNIWMMEVQATARDQCMFVLLRITNTVGPVDLALAFVFLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKD6</accession>
    <name>K0IKD6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58852">
        <property type="protein sequence ID" value="AFU58852"/>
        <property type="gene ID" value="Ngar_c19200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19200"/>
    <dbReference type="HOGENOM" id="CLU_159744_0_0_2"/>
    <dbReference type="OMA" id="DEYMIGV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1918-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11323" checksum="9E1C8EE56F42C27E" modified="2012-11-28" version="1">MPEHCSTKVDGQECQLAPSYVVSVKSNEGDDEYMLAVVCEEHKNGIEARLLAMQKENRVPQGKIHFQPVKAVVTDCVMGMNEDYIDLELKRGIASDRKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKD7</accession>
    <name>K0IKD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27720"/>
    <dbReference type="EnsemblBacteria" id="AFU59693">
        <property type="protein sequence ID" value="AFU59693"/>
        <property type="gene ID" value="Ngar_c27720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27720"/>
    <dbReference type="HOGENOM" id="CLU_1718274_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2772-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="SSF54160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="18180" checksum="E1D7D579E6BD1285" modified="2012-11-28" version="1">MPITLATLQSKIHSEVQNLTNAQLIKDYDGFHEINRISESRRKNNLKGITYYAKWLSVTYPSMTFYDVKNRELHILPFLNGYRKTAKDDPEEKWVITCNDYRSRLIHFFRWLHNVKIKGRASDEVPLDDWKTPKFVRIKKQKTKRKNTYSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKF7</accession>
    <name>K0IKF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19650"/>
    <dbReference type="EnsemblBacteria" id="AFU58897">
        <property type="protein sequence ID" value="AFU58897"/>
        <property type="gene ID" value="Ngar_c19650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19650"/>
    <dbReference type="HOGENOM" id="CLU_1954731_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1963-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14158" checksum="16D171D27941DAEE" modified="2012-11-28" version="1">MAIEQKPIREAVPHIFRRPVLSVEPHDSLLKAGTFLAIGPQIYVDGLVVLDGTSPVGRIGGKSIIKHILESREWQYAKVTDMVDRSVYGVDAGSNLGYALDIFDETRFAFVPVTINYKIAASLTIRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG7</accession>
    <name>K0IKG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28330"/>
    <dbReference type="EnsemblBacteria" id="AFU59753">
        <property type="protein sequence ID" value="AFU59753"/>
        <property type="gene ID" value="Ngar_c28330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28330"/>
    <dbReference type="HOGENOM" id="CLU_2519880_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2833-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9596" checksum="3D526C4C810EED2F" modified="2012-11-28" version="1">MDSDSIYNYTTKILSIKRRLEQFDDDDKTGNGKVASEFLDALGDHGLSKGRVVYYAARLPIIMQWFASRRIILKMLLKTIAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP0</accession>
    <name>K0IKP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59878">
        <property type="protein sequence ID" value="AFU59878"/>
        <property type="gene ID" value="Ngar_c29600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29600"/>
    <dbReference type="HOGENOM" id="CLU_3302866_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2960-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="39" mass="4409" checksum="4E5B035AF0ABE6BF" modified="2012-11-28" version="1">MNAIKSVGKFVTATTNNIPYNLGMSFWQLHTTTYFQIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ0</accession>
    <name>K0IKQ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59898">
        <property type="protein sequence ID" value="AFU59898"/>
        <property type="gene ID" value="Ngar_c29800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29800"/>
    <dbReference type="HOGENOM" id="CLU_094092_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2980-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="258" mass="29370" checksum="E439A76B4618DCF7" modified="2012-11-28" version="1">MERIHSLCLIEGSEDTGYPALYDIVSKYASRNYAVIYAVENDVAETVRHMSRRIDVETLVESGALTIVDRNVMYSVEKTNNLEGQAILDSWHSLMLKVKKRSNSDGILAIGSAETFFEHHVDPCKLVNYETIVGKKFHIPLEAICCYSANAFSRLSFGDLVAILNAHHSTIHTNNRYREWHPSKFIELARSGLDRALGHELSDLIFKTMKLCYRINDSHIISRPQILEDMLERIMGKKAADATMRYVKDEVRKSVAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKU7</accession>
    <name>K0IKU7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase</fullName>
            <shortName evidence="6">PvlArgDC</shortName>
            <ecNumber evidence="6">4.1.1.19</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit beta</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit alpha</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">pdaD</name>
        <name evidence="7" type="ordered locus">Ngar_c30920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="6">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PdaD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30920"/>
    <dbReference type="EnsemblBacteria" id="AFU60008">
        <property type="protein sequence ID" value="AFU60008"/>
        <property type="gene ID" value="Ngar_c30920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30920"/>
    <dbReference type="HOGENOM" id="CLU_114389_0_0_2"/>
    <dbReference type="OMA" id="SEHHSFG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00286">
        <property type="entry name" value="TIGR00286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_5023567408" description="Pyruvoyl-dependent arginine decarboxylase subunit beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023567407" description="Pyruvoyl-dependent arginine decarboxylase subunit alpha" evidence="6">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic)" evidence="6">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="6">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19417" checksum="357DDE8C7304D82F" modified="2012-11-28" version="1">MFFTKGKGMHKDYLTSFELALRDAEIADLNLVSVSSILPPRCKIVSRQEGRKYLRPGQVVFAIMARAATNEPNRLIAASIGLARPADESQHGYLSEHHPTGETAQKAGDYAEDMAMEMLATTFGLPNDPSLTWNEREEQWKLSGKIYRTQNFTQSAEGNKDGLWTTVVSAAVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL19</accession>
    <name>K0IL19_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">atpD</name>
        <name evidence="7" type="ordered locus">Ngar_c31920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31920"/>
    <dbReference type="EnsemblBacteria" id="AFU60108">
        <property type="protein sequence ID" value="AFU60108"/>
        <property type="gene ID" value="Ngar_c31920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3176"/>
    <dbReference type="HOGENOM" id="CLU_069688_2_0_2"/>
    <dbReference type="OMA" id="SKNIMGV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="25035" checksum="961DC4AFC281FBAF" modified="2012-11-28" version="1">MSFGRRVTATKIELIKIRRSMQVAKMVHKILDDKREVLLKKIDEMIDEANKAREDIWTPLGEIYSSVYQAYMSLGTSTLESISDSTPSVMEVDVNVRRIVDVKIPTLQVKTKEGGQALSYGFVETNASVDKAAKLIKNMLPGICKAAEYENAIFSLAKELERTQKLINALEYVIIPQYQDAMAFIKATLEEREREEFVRLKKVKVVLDKKKVAEAEATGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE8</accession>
    <name>K0ILE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RelE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00840"/>
    <dbReference type="EnsemblBacteria" id="AFU57034">
        <property type="protein sequence ID" value="AFU57034"/>
        <property type="gene ID" value="Ngar_c00840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00840"/>
    <dbReference type="HOGENOM" id="CLU_155761_3_1_2"/>
    <dbReference type="OMA" id="MKYAFRF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-84-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9966" checksum="A737AE08F8702D2A" modified="2012-11-28" version="1">MTFEIRWTESSFNKLQKLDFLTQTRIIEKLDEAASDPFLVAKKLTGVNLYSIRIGDYRVIVSIEKNKMIVFVIDLGHRSKIYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM1</accession>
    <name>K0ILM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59557">
        <property type="protein sequence ID" value="AFU59557"/>
        <property type="gene ID" value="Ngar_c26350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2609"/>
    <dbReference type="HOGENOM" id="CLU_1248320_0_0_2"/>
    <dbReference type="OMA" id="AWKNIYS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2635-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="230" mass="25583" checksum="EB73C270D5FA8155" modified="2012-11-28" version="1">MVGAQVKDEKSTIAIFDTFKTRKNKFTGEAKRQRGIIAHLATEQSPELRTRTSIAHAIAKQHGILWQNIYSGIFRDLDEVLIPAGVVKEGGRLPLRRGPKALQLEGVPFYELTDAGMLVASAIEELGDKRMKLLQSYISSLPAGDTNSRTMKEGMLFLIVAAPSFISKIISEYIYAYSTGAIDTIAPLDAKKLRSVIAKQITVEKELVEAFVTMQQDHKDLVRNFFKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILN2</accession>
    <name>K0ILN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59577">
        <property type="protein sequence ID" value="AFU59577"/>
        <property type="gene ID" value="Ngar_c26560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26560"/>
    <dbReference type="HOGENOM" id="CLU_211863_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2656-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6560" checksum="3827D7CC8A1ECA3E" modified="2012-11-28" version="1">MASEVSRKYQEEILRLLSEIVAELKESNILLKEHNSAIDSIKNRIRKIGFSTTNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP5</accession>
    <name>K0ILP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TfuA domain protein, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02510"/>
    <dbReference type="EnsemblBacteria" id="AFU57199">
        <property type="protein sequence ID" value="AFU57199"/>
        <property type="gene ID" value="Ngar_c02510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.245"/>
    <dbReference type="HOGENOM" id="CLU_090311_0_0_2"/>
    <dbReference type="OMA" id="MISFREM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-251-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012924">
        <property type="entry name" value="TfuA_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07812">
        <property type="entry name" value="TfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfuA" evidence="1">
        <location>
            <begin position="53"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="226" mass="25202" checksum="198F67AA34708780" modified="2012-11-28" version="1">MEKKPVIFLGPSLSHEKARKIFADADYRPPAKKGDFLRLAADPTGVKLVGFVDGVFLQDYPPTPIEVYQLARKEGVLLAGAASLGALRAVELEKFGMVGIGRIFQLYKTGKVNADDEVAVTFAPEGDYLLQSEAMIDIRYNLYLAHKKGVIGKKTKSALTHVAKRIYFPHRNYPNIIEEARGRYPALAGEVDSFGSYIASNRKSLKEMDAMMLVKFLKERYESLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT2</accession>
    <name>K0ILT2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59662">
        <property type="protein sequence ID" value="AFU59662"/>
        <property type="gene ID" value="Ngar_c27410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27410"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_2"/>
    <dbReference type="OMA" id="NGMIGRT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2741-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13219" checksum="19DED9EF606A2167" modified="2012-11-28" version="1">MAKSNRAICLCPLEGVIDIISKKWALLIVNEIGNHGRIRYNDLMKEIQAISPKTLADTLKELVKYNLVKREAFNEIPPRVDYTLTKDGEELRKSIIPILQWALSKKGTVIAHCSCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY9</accession>
    <name>K0ILY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57449">
        <property type="protein sequence ID" value="AFU57449"/>
        <property type="gene ID" value="Ngar_c05050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05050"/>
    <dbReference type="HOGENOM" id="CLU_1438160_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-503-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="19621" checksum="7980453642CF66FF" modified="2012-11-28" version="1">MHLKRGHIMLIAGGALVVVSFSMLGYYGLQFVSSIQQDKSLTVEPGGSLQVQQNINASQGAYVVAFPNFKGQPSVTITGPGGQVVVERTIEPPIIIEPFDAEQPGAYTLVLSNPTDQVLEANIVLGDQETVLSRGINISSAVTALVFTSLLGIGIAVAVAGAIITILDRRRISKMKQFGDTRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM87</accession>
    <name>K0IM87_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c31810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31810"/>
    <dbReference type="REBASE" id="55346">
        <property type="entry name" value="M.Nga92ORF31810P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60097">
        <property type="protein sequence ID" value="AFU60097"/>
        <property type="gene ID" value="Ngar_c31810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3166"/>
    <dbReference type="HOGENOM" id="CLU_024927_2_1_2"/>
    <dbReference type="OMA" id="WERLIQF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3181-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="309" mass="34503" checksum="1B6FBB03B06CD93F" modified="2012-11-28" version="1">MATIDSSRSSYVKKMQRINARLLHVFVDPLQNQEDAPYGVVQKNGCSATFYLKDCISGLKENVGEKSVDVVVTSPPYNIGIGYGSYNDALPREKYLAWMEEVGVAVKQALADDGSFFLNIGNKPKDQWIAWDVASVLRKHFVLQNVIHWIKSIAISKADVGNYPNIAGDIAVGHFKPIVSDRFLNDCHEYIFHFTKAGDAHLDKLAVGIPYQDKTNIGRWKTAKEDRRDRGNTWFIPYETIQSKSERPHPATFPVKLPEMCIKVHGGAKMVVDPFTGIGSTAVAAVRLGIPFVGFEIDREYLDVAISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB3</accession>
    <name>K0IMB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57724">
        <property type="protein sequence ID" value="AFU57724"/>
        <property type="gene ID" value="Ngar_c07820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07820"/>
    <dbReference type="HOGENOM" id="CLU_2519874_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-780-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9567" checksum="47B01C0031881AF9" modified="2012-11-28" version="1">MSKKEFSCEEPVSAERLKIAFDKSLSILGQSSKEALLHDLQNKGIDLDGTNPYSFKQIEQALENILGEDATELLIQRWWKALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB5</accession>
    <name>K0IMB5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07870"/>
    <dbReference type="EnsemblBacteria" id="AFU57729">
        <property type="protein sequence ID" value="AFU57729"/>
        <property type="gene ID" value="Ngar_c07870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07870"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_2"/>
    <dbReference type="OMA" id="EFVWARQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-785-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="274" mass="31582" checksum="5B45585AE2273922" modified="2012-11-28" version="1">MKYKIIEKAGSGGFGNVYKVEGNDGNIYAMKLLKDLNAVNKQRFDREIKILAQLDHPNIVKIVEWNLGGDPPDFSPWYTMEYLRGGSLRQHMDEKFRENYVFQRNWTIKTVILPILHAFGQAHHAGIYHRDLKPDNILYTDDHRAQIKITDWGLGRDIDRKSLALTAATGEVGGTPGYCAPEQWFSLDNIDGRADIFSLGVIFYEMMTGKRPPSYNNDMKRPVIEPPSRFHPTISKDLDAIILRMVDLDPEKRYTSVLELIPDIELLEDARYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME7</accession>
    <name>K0IME7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative major facilitator superfamily MFS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60202">
        <property type="protein sequence ID" value="AFU60202"/>
        <property type="gene ID" value="Ngar_c32870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32870"/>
    <dbReference type="HOGENOM" id="CLU_1599073_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3287-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="166" mass="17711" checksum="9EF59D9D8F643B58" modified="2012-11-28" version="1">MKNRDNTANRFLSKDVAASLSIIIARIFHAVNWFNVAAIFPLIALDFENDDIALLGSISAAFFIGVGIFQIPAGIFAAKFTPRSSAIFGIALSSIAALLYGFSSEASQLVWLRFIVGAGMAFFFSSGIVLIARYASAKFSGFSIGLMNSAHSAELSGYLLGLLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH3</accession>
    <name>K0IMH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c33670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60282">
        <property type="protein sequence ID" value="AFU60282"/>
        <property type="gene ID" value="Ngar_c33670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3357"/>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3367-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="19367" checksum="0D20AD8AC0517D7E" modified="2012-11-28" version="1">MPIDADFPRNHQVIGKHQHSDGEHFHFVWGPGAAKEAAENEEVKAAYQARGEELAPIGVHGTMVAIDWDSCIADGACIEACPVQVFQWYRTENDVPATQMANATSAGTGSSVKEERKDYTDKADPIREHDCIWCMACVSVCPPQAVKVDQSNLEFHEKASGTFNEALAKGSAPPPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ7</accession>
    <name>K0IMJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name evidence="2" type="ordered locus">Ngar_c10070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10070"/>
    <dbReference type="EnsemblBacteria" id="AFU57949">
        <property type="protein sequence ID" value="AFU57949"/>
        <property type="gene ID" value="Ngar_c10070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10070"/>
    <dbReference type="HOGENOM" id="CLU_071484_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="281" mass="32047" checksum="40B1F35AF3DCE636" modified="2012-11-28" version="1">MTAKHENILDTFTSQEVEALTTSQDYIESQIKQELINELKKLDIGANEAKILIFLMSNGSTTASDISRHTGIQRTDTYHYLSSLLAKGVVLSSFSKPQKYYALSFDEVIDCLVQSKYDTLKTVLNAKKRCQEKLDKIIKVTKPTRQENSYQVLNEESLYSRIKSMLGEVSTKVTVYLSQKMLVKFYHAEIADMLIALSKRGVNVRIRTESKKTVEGYEGLDNEAFSFNVFSPLPVNFIIFDDNRMIIISEEDKEGIHDLTGFYTNKSALISTFDYLFGRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK8</accession>
    <name>K0IMK8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57979">
        <property type="protein sequence ID" value="AFU57979"/>
        <property type="gene ID" value="Ngar_c10370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10370"/>
    <dbReference type="HOGENOM" id="CLU_2893367_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1035-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7231" checksum="F0C5091BF3533C2A" modified="2012-11-28" version="1">MAATNWSLAYVASLGGWENTEVLNKCYGGIPEHIKAQIAKSVHVKFDTLDLRVASTTNYSAIISFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT7</accession>
    <name>K0IMT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12540"/>
    <dbReference type="EnsemblBacteria" id="AFU58194">
        <property type="protein sequence ID" value="AFU58194"/>
        <property type="gene ID" value="Ngar_c12540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12540"/>
    <dbReference type="HOGENOM" id="CLU_2712963_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1252-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8187" checksum="DDF26D2C9331D0BF" modified="2012-11-28" version="1">MKILVAEDEQSIARMYKLALEGMKHEITVVNDGDACVGMYKANRQQAKNDRPFDVVLLDHRMPIRDGIEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU4</accession>
    <name>K0IMU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12890"/>
    <dbReference type="EnsemblBacteria" id="AFU58229">
        <property type="protein sequence ID" value="AFU58229"/>
        <property type="gene ID" value="Ngar_c12890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12890"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1235"/>
    <dbReference type="HOGENOM" id="CLU_104845_0_1_2"/>
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    <dbReference type="BioCyc" id="CNIT1237085:G1324-1287-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="15703" checksum="A00D6933FB026B5F" modified="2012-11-28" version="1">MIEDKLASLGITLPSPPAPAGSYVPVVVTHNNLAFVAGQIPTEGGQVKFKGKVGRDISIEAGQQAARLCTINALAQLKSALGSLDRVKRAVKVTGFVSCDPLFADQPKVINGASDLLVQVFGENGRHARAAVGVSSLPLDSAVEVEFIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV6</accession>
    <name>K0IMV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58289">
        <property type="protein sequence ID" value="AFU58289"/>
        <property type="gene ID" value="Ngar_c13510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13510"/>
    <dbReference type="HOGENOM" id="CLU_202281_0_0_2"/>
    <dbReference type="OMA" id="MGEITIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1349-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6790" checksum="9786A4ED23A3CB62" modified="2012-11-28" version="1">MPSVGEVTTLAKNSPKFASLRTTVPMSVVKQWKLKEGDKLEWEWKVVDGEMALVIKKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN49</accession>
    <name>K0IN49_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c18210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18210"/>
    <dbReference type="EnsemblBacteria" id="AFU58754">
        <property type="protein sequence ID" value="AFU58754"/>
        <property type="gene ID" value="Ngar_c18210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18210"/>
    <dbReference type="HOGENOM" id="CLU_166867_0_0_2"/>
    <dbReference type="OMA" id="HVKPIAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1819-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14582" checksum="EBF04F71E9C303C7" modified="2012-11-28" version="1">MHPAYNMSSTQSMGRLEERNLNTKPDETRKFDKGKLDIANIGDVSIGRFTLEPGWKWSTSVKPIVKTDSCQQHHTGYIISGRMRVRMDNGTEMECGPGDVAIIPPGHDAWVEGNEPCIGIDFTGAKTYAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN83</accession>
    <name>K0IN83_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane bound type IV pili protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c19920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19920"/>
    <dbReference type="EnsemblBacteria" id="AFU58924">
        <property type="protein sequence ID" value="AFU58924"/>
        <property type="gene ID" value="Ngar_c19920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19920"/>
    <dbReference type="HOGENOM" id="CLU_385271_0_0_2"/>
    <dbReference type="OMA" id="WITAMER"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1990-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="272"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="717" mass="78492" checksum="012AEFB3E2FCA49B" modified="2012-11-28" version="1">MVKADSRITYLIIIALLIACSYIGLHVFIQYSASGFVYTQIAGIMLTGIGVGGVLVLLTYAIELWKKPEYLELRLSWQPNPILVSYIASAVVLYFGIGVVLSALTPVNENYTDTLGPVLIGIGITSLTITAIFHYRSAAKARGSGKGSGKEVTVKPFENDLGLRVVSRNNILSAIARTMSTRLLTPEVIKSGMLANPQVLSSKYVFFSLLALVASVPLTAFALISLQQYDAPLFPAFLFLLAPLAMLVMPYLKLKSMAGDRKRGIEDELPFFCTYASVMQSVGLSLYNSFENIASRNVFANLEKEALMIQRNVQFFFKNQVEALEQAGRVHPNEKFRGLLLGYTSEWRSGGDTVHYLDAKSKELLNDMRFRWQRYTAMVSDIGEVMVSLFFIMPVLILTTAFVFPLQTTVITGAVVAVLIPLLTTVVFMMISNMQPKTYDLIEGKTTFSVVAAIASFVVAYFLSHSTVWIALATSIISTGVFYGTSVIAQRREIALVEKALPQFLRDITEYKKMGYDINKSVFKIAEENSYNTTFDALLKNTAKQMRMGLRLSDAEIKVRSWLGRLTFFLLGEIVNSGGGTASALETLTNFVSNVNQIKKEAKSTMQLYEVLTYLTPIGLAFTVALMASLMTAFSSTVASASEVGILKQISSVPDELIQTTNMMIVAASASMAFVAGKAIDLTSKNTLRIAVTAAIAAISISLSTEFVSGIIRMVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE1</accession>
    <name>K0INE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59214">
        <property type="protein sequence ID" value="AFU59214"/>
        <property type="gene ID" value="Ngar_c22860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22860"/>
    <dbReference type="HOGENOM" id="CLU_2802398_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2284-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7402" checksum="DA69E939D363EED2" modified="2012-11-28" version="1">MAHAGHIVVTTSEYPQSVQTSFVPATVFSRTSCTVFEWHLMHSLDTVSGLGIYVLAPLYTDKAKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE8</accession>
    <name>K0INE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59249">
        <property type="protein sequence ID" value="AFU59249"/>
        <property type="gene ID" value="Ngar_c23230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2298"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="KVMTGQY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2321-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="324" mass="35395" checksum="5B97835D1229E647" modified="2012-11-28" version="1">MRIAKALVTGGAGFIGSHIVDELIARGIETYVIDNLSTGTLNNLVQHRGNSLLHFMAGDVREAEALLQDTNIDVVFHEAAIASVPKSVSHPLLVHDVNVNMTLHLLNYCVKSGVKRFIFASSAAVYGILESKATEDMACRPNSPYGAGKLAIEDYLHAYRRTYGLETVMLRYFNVYGPRQIYSDYSGVITIFINKLLEGERPVIFGDGLQVRDFVHVSDIVQANMLAMDSAAAVGEMFNVASGRATNILEMVKIIKKLMGATDIEHQFAPPRPGDMKLGLASIDKIRAVLGYDPKIQIQQGLKGVIESISKIQVPKIQHAGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH2</accession>
    <name>K0INH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59369">
        <property type="protein sequence ID" value="AFU59369"/>
        <property type="gene ID" value="Ngar_c24450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24450"/>
    <dbReference type="HOGENOM" id="CLU_1559406_0_0_2"/>
    <dbReference type="OMA" id="RVIWINE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2443-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="167" mass="18868" checksum="A04DC39D055D00CE" modified="2012-11-28" version="1">MFSRGGIKPGEYVFVVQKEGNFSRIIIGRIQSVNGSRVHVVGTHVRPIGLIERIQAGRAGGRPMEIINNPDPNNCIFMLIDRVETGRFNEEVDQATSRVIWINENRYLVLDGWIKENFPEIFAAALSAETAEARAQARQTLIEKMNSLYERDLKDHVYAVARSAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ2</accession>
    <name>K0INJ2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyS</name>
        <name evidence="7" type="ordered locus">Ngar_c25470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25470"/>
    <dbReference type="EnsemblBacteria" id="AFU59469">
        <property type="protein sequence ID" value="AFU59469"/>
        <property type="gene ID" value="Ngar_c25470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2524"/>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_2"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="34"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="522" mass="60011" checksum="3A1AC214C2EA351E" modified="2012-11-28" version="1">MLCLRNKTVLHKIWTINLKPVSHVCSLQMVANYDEVMKLALERGFYFPSCEIYSDAPAGFWEYGPTGVNMKNKFVELWRRELVRRDGMMEIDGCQIMSKSVFVASGHISNFTDPIVKCTKCGSTFRADRYITEKTGENVPERMADEEINALIKKHNLRCPNCKGEFGGVSRFNMMFRVGIGPAAEEAYLRPETCQTIFVDFARVFKTMRGRLPLGIAQVGKSFRNEIAPRQSLLRLREFYQAEIEVFCNPNRLNEMPKFEEVKNTFLRISSHDGSAITEATAQEAIDKGLIPNKLVAYYLALLIEFYDKTGIDVKRSRFRRLSDEEKAFYASVAFDFEVETSIGWLELVACNYRSDYDLKGHGATSKQNLEVVDPADQTKVLPHVFELSMGIDRSIYTILEHCYYEDEQHDDRVVLKLKPYLAPILVGVLPLMTKDGLDEKARKIHSDLKYDFDTFYDESGSIGRRYRRLEEVGAPFAVTIDQTTMQDDTVTVRHRDTMQQERVKTSELRQYMQNALDAARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL1</accession>
    <name>K0INL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59564">
        <property type="protein sequence ID" value="AFU59564"/>
        <property type="gene ID" value="Ngar_c26420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26420"/>
    <dbReference type="HOGENOM" id="CLU_2679066_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2642-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8369" checksum="491BEB6779BA328A" modified="2012-11-28" version="1">MLLGLSISAYKKTALKSTIYASVAFGLFAAQLFFDYLEDAVKSFEQPYNDVIFYAMTLAILVLFFLAVVRRNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU0</accession>
    <name>K0INU0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative methylase N-4/N-6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c30430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="55347">
        <property type="entry name" value="M.Nga92ORF30430P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59959">
        <property type="protein sequence ID" value="AFU59959"/>
        <property type="gene ID" value="Ngar_c30430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30430"/>
    <dbReference type="HOGENOM" id="CLU_024927_10_0_2"/>
    <dbReference type="OMA" id="WPTKHDN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3043-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="354" mass="41713" checksum="E631CCCEDA21EB0B" modified="2012-11-28" version="1">MAQRTRLALKPHDSDLKKNLLFHCDNLDCINYLQKHGFESKIDLVYIDPPFLSGERYFRRVDNDSNLAFEDLWKQSKYLEMMHKRLAEIRKLLSKDGSIFVHLDWHAVHYVKVMMDRIFGPENFRNEIIVKRGRRKNLQYQFESIDRMHTAYDSILWYSKSAETKFAPPLAKHHSKAKWMGFWSNVNRPTMRYEIFGVRLVRGQWKWAKERALKAVENYRLYEQKFSSMMTLEEYWESTGKKLEFVRKRPGVKYAEYWIPPKTHRIIDNVWLDIQAYNYSTGYGTEKHAQLLERIIGQFSKEDGLVADFFCGSGTTLAIAQKLGRRWIGCDSSPAAIAVTKKRLGSGFSIVNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6T5</accession>
    <name>K0I6T5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56966">
        <property type="protein sequence ID" value="AFU56966"/>
        <property type="gene ID" value="Ngar_c00160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00160"/>
    <dbReference type="HOGENOM" id="CLU_2662482_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-16-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8571" checksum="CB4B51E1B42446B8" modified="2012-11-28" version="1">MSARKFLKLIRYMLLPGGSAKISTRLLAGQEEFSKFWGFLASWDTKGLSLIRYLSCIIVIENHAALIHDLCHRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I868</accession>
    <name>K0I868_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57461">
        <property type="protein sequence ID" value="AFU57461"/>
        <property type="gene ID" value="Ngar_c05180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05180"/>
    <dbReference type="HOGENOM" id="CLU_2581531_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-516-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8451" checksum="6C8446E6DE9CA77E" modified="2012-11-28" version="1">MLRLEQMTPKKKRITTVAIAGAASIALAAIAMMAYPVSYQAIVNGFSYVVEGVSGIFAMLSENVRNAVASAQSLLEGQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I900</accession>
    <name>K0I900_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08040"/>
    <dbReference type="EnsemblBacteria" id="AFU57746">
        <property type="protein sequence ID" value="AFU57746"/>
        <property type="gene ID" value="Ngar_c08040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08040"/>
    <dbReference type="HOGENOM" id="CLU_1431690_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-802-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="20432" checksum="3E234D8205249EB2" modified="2012-11-28" version="1">MEEYAGRRRSSGFPDNLGVALPAGEPAGLGSGPEFIRTTLPTSAIRQSLGRTTPLPEEKEIQEIPAGSTQSVRVGSGGPSQGSLSVGDQAEAIFQMKSFYRTNLPRLGTGASIPVGHLHTSLLEPSNGGAVISDQQFQDARNSYSRMGVIDDYNTCHCRHPSQSDGGQEKLFLEFRASFYNRWPSCRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBE0</accession>
    <name>K0IBE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58611">
        <property type="protein sequence ID" value="AFU58611"/>
        <property type="gene ID" value="Ngar_c16780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16780"/>
    <dbReference type="HOGENOM" id="CLU_009583_14_4_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1676-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="404" mass="45391" checksum="1F6FE0ACF0FD9890" modified="2012-11-28" version="1">MKKILMVSTEYPPMPGGVGRYAANLTRALEKYGSNKVIVVCDEKGKGDYAGSISPSNPRNSDNLLKIVDDVKPDIVHVQFEPGLYGLFLDAVDPRKSATYIDSFYENCKVPIVTTFHSAYTFREWVGQSLLVKRTGRTGKFGVPVRLAVRMWKSLLHYNSFHDLNKEKLALSQAGICFSHYMTKILGGGHIVYHGAEPTVSPVPGKKEARSRMSLPYEKKLAVVIGFRTMTKGWDILEKMRMPEGWALVINSSRSHYNNENLETTGFFAGRSDVIDLQRGFLSDEDLSTLMLACDAVLLPYKIASGSGVMFDALAHGLPFVASDLEFFKEFAKMGLGIITHRDQKSFVKALSKLDRNYGKYSSNVEQFRQKLRWEHVARQHMQIYEEAGKGIIKGKKKTQAQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBM4</accession>
    <name>K0IBM4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">topA</name>
        <name evidence="10" type="ordered locus">Ngar_c00150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00150"/>
    <dbReference type="EnsemblBacteria" id="AFU56965">
        <property type="protein sequence ID" value="AFU56965"/>
        <property type="gene ID" value="Ngar_c00150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.17"/>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_2"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005739">
        <property type="entry name" value="TopoI_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01057">
        <property type="entry name" value="topA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU56965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="685" mass="75013" checksum="F6906C3E028FC3D0" modified="2012-11-28" version="1">MYTLVVCEKPDAARRIAQALGDPKESKPAGISVFDVANSDCHYKVCSALGHLYGLADSTKNRSVYPVLDLEWAPVDKNPRAARAIKVISELSKNASAFVHACDYDQEGEVIGHNILQYACGGKYEKALRAKFSTLTDEEIRESFASLERPSGGLAEAGRSRHMLDFIYGVNLSRALAQSLKMASNGYCNLSIGRVQGPTLAFAVDRELEIRLHVPDPYWTIAAQFEKNNQTFSAQYEKPKVGTLAEAKSIVSACIGRDGTVSDVVDSKAVLGPPTPFNIGDLQREAYRLFKLGPGYTLAIAEKLYLQALISYPRTSSQKLPPSIGYGKIISSLSRIGGYGQLTSMLLSKGRLVPNEGRMTDPAHPAIYPTGVAPQQKLSSLEFKVYDLVVKRFLATFGDPAISRHTDVSIDVNSHTFKAQGRSPVYEGWMVFYKPHVRLEQHELPELRKGDLVKNLGIDMEEKFTQPPYRYNQASLLAKMEQEQIGTKATRADIIATLFKRNYIASSVRGGIEVTDLGFAVIDSMRTFVPAIISTSLTRSMEEQLEKVEQGSAESVLVIEQAVDKLIESLSAFIEKEVDIGARIGNAASSSANGAQAATMIGSCPVCKKGQLRMIKSYKTKKRFVGCSNYSGGCKATAPLPQKGAIRVLGKACPECGWPIVGVVFARRSKHWKICVNMQCPSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBQ5</accession>
    <name>K0IBQ5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF35_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17480"/>
    <dbReference type="EnsemblBacteria" id="AFU58681">
        <property type="protein sequence ID" value="AFU58681"/>
        <property type="gene ID" value="Ngar_c17480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17480"/>
    <dbReference type="HOGENOM" id="CLU_168008_0_0_2"/>
    <dbReference type="OMA" id="WPPSHRC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1746-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11406" checksum="5FE0E439949416F0" modified="2012-11-28" version="1">MKKGKFMVPTCISCGSKVWPPSHRCPYCLSKTSLKKIETTGILLEFSSSHIKGKEGVFGLIEMSGIKLIGSFGTPQLKEGMKVKMTRCGVRPDGTAFYSFAPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBQ9</accession>
    <name>K0IBQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="2">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bioF</name>
        <name evidence="2" type="ordered locus">Ngar_c17580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.47" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17580"/>
    <dbReference type="EnsemblBacteria" id="AFU58691">
        <property type="protein sequence ID" value="AFU58691"/>
        <property type="gene ID" value="Ngar_c17580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1733"/>
    <dbReference type="HOGENOM" id="CLU_015846_11_2_2"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="389" mass="42384" checksum="B8B90EF287C4DE78" modified="2012-11-28" version="1">MASKHKKTAAFVKERLDFLERNDLYRRLRTVEVEGPAAVVDGKEVIHLCSNDYLGLSQNKQVIKKTIKALQEVSQCSSRLIAGNHPTIMELEGLLADHRKTESALVYPTGYSANLGAITAIAGKSSTIFSDELNHASIIDACRLSGATVKVFRHNDAGHLDELVRQTKGGSKIVITEGVFSMDGDMARLPEICSIAKENDAITIVDDAHGDFVFGPKFSGIPAKFRTDVDIHISSMSKGLGCFGGYVATTEHLRELLINTSRQFIYTSALPSHLCSAAIAAIPLAKVGDLQKKLYKNIAYFIDAMKKLGFVIGNSSSQIIPIMIGPERLAVEFSKELLRQGVFAQAVRYPTVRKGSARLRVSLTAMHTQKHLDAAIDVFGKAGRKTGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBT4</accession>
    <name>K0IBT4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiA</name>
        <name evidence="6" type="ordered locus">Ngar_c17980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17980"/>
    <dbReference type="EnsemblBacteria" id="AFU58731">
        <property type="protein sequence ID" value="AFU58731"/>
        <property type="gene ID" value="Ngar_c17980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1777"/>
    <dbReference type="HOGENOM" id="CLU_022752_2_0_2"/>
    <dbReference type="OMA" id="QPFKCGP"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="248"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="456" mass="49846" checksum="51343634FAD62818" modified="2012-11-28" version="1">MQIPRIVIAGVTSGVGKTTVAVAVMHALRRKGGLKVQPFKVGPDFIDPSYHTFVTKRQSRNLDVWMMGKQGVLDCFVGACQGADVAVIEGVMGLFDGMSGKDDFASTAHVAKILDAPVVLVVDAAKSARSIAAIILGFLQFDKNLRIAGIILNNVAGERHAGYITDALAGKIKVPVVGIVRRNSEIRMEERHLGLVPAPELHEVKRKAIVAAAKYVADQIDIDKILKLCGTSLLSDAPVRTRLDTKSRIAVALDESFNFYYADNLDALRRSGAELVFFSPVQEARLPEYIHGIMLGGGFPEVLADRLERNQSMIKSIRKAVLDGMPIYGECGGLMYLTRSIRGYKGEKKARKMAGLVDADTLMTSRLTLNYTEAVCDGPIFGRTRLRGHEFHYSSIENVARDSKFAYSMKKGKGITGDKDGLVVNGSGLAAYMHLHFADTKLPDRLMQACARYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBV5</accession>
    <name>K0IBV5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58766">
        <property type="protein sequence ID" value="AFU58766"/>
        <property type="gene ID" value="Ngar_c18330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18330"/>
    <dbReference type="HOGENOM" id="CLU_176746_0_0_2"/>
    <dbReference type="OMA" id="RIILYAQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1831-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12050" checksum="7B3137D1E791F79E" modified="2012-11-28" version="1">MDDFLLPAENVRFSSKDSIAEYAEKRYRVLVTDKRLILYAQRGMLMKSDDIISERLDSLHGLKYFERGTIFRSAVVSVQGTVKFDIKGSPSHLKPLYHSLQAVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBX6</accession>
    <name>K0IBX6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pth</name>
        <name evidence="4" type="ordered locus">Ngar_c18740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18740"/>
    <dbReference type="EnsemblBacteria" id="AFU58806">
        <property type="protein sequence ID" value="AFU58806"/>
        <property type="gene ID" value="Ngar_c18740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18740"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1858"/>
    <dbReference type="HOGENOM" id="CLU_073661_2_2_2"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12071" checksum="133C7E6572EDA444" modified="2012-11-28" version="1">MVVRRDLGMGTGKIAAQVAHAAVMGAEKTKAHRRAWFDAWFEGGQAKVVVKVKSMEELMEIRKRAESYRLPVVQVQDSGLTQIPPGTTTCIGIGPAPADLIDKVTNDLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBZ7</accession>
    <name>K0IBZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58846">
        <property type="protein sequence ID" value="AFU58846"/>
        <property type="gene ID" value="Ngar_c19140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19140"/>
    <dbReference type="HOGENOM" id="CLU_2613752_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1912-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8725" checksum="FEDCB94338F4054A" modified="2012-11-28" version="1">MGYYFLHKAAFTKSDKFDKGFAIGIGSVAANLSKDLLHESLLSEGKRNESFAENFGFGVGHIISLLDSDKRHFRNNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC32</accession>
    <name>K0IC32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58911">
        <property type="protein sequence ID" value="AFU58911"/>
        <property type="gene ID" value="Ngar_c19790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19790"/>
    <dbReference type="HOGENOM" id="CLU_1682757_0_0_2"/>
    <dbReference type="OMA" id="MNVFRIN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1977-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="16557" checksum="18A29FEB71C14D9B" modified="2012-11-28" version="1">MVFSNKAYVALAAAIAGSFWIVLATFDQLLFFSPVVVFYLPSDATINFTLSNIMAGTAGIVVSMNVYVLRHSRLKLGTSLFSGSTAGVVSSACAGCSSFGFLLVTTFGGAGAAASTFLSVHQIPLRLISIGLLLWSYYSVHNRLTKSCIMTDGHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC78</accession>
    <name>K0IC78_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mdh</name>
        <name evidence="8" type="ordered locus">Ngar_c01960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01960"/>
    <dbReference type="EnsemblBacteria" id="AFU57145">
        <property type="protein sequence ID" value="AFU57145"/>
        <property type="gene ID" value="Ngar_c01960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.196"/>
    <dbReference type="HOGENOM" id="CLU_045401_2_1_2"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="7">
        <location>
            <begin position="146"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="305" mass="32461" checksum="8EC15A1BED7CCD3F" modified="2012-11-28" version="1">MTITIIGSGKVGASAALNCGLRELDRDILLLDIVQGLPQGEAMDINHQLSERGSDAVARGSNNYEDMRGSDYVVLVAGVGRKPGMTRMDLLKTNAGIVKDVAGKIASYAKDATIIVVTNPLDPMTYLALKAIGAKKNKVMGMGGMLDLSRFKSFIQDATKISRDSIQAMVISEHGENMLPLTRFSSIGGIPLHEFISKDKAMEIFEKTRKVAAEVIALKGATVYAPGNAVATMLESAIRDKKLVIPVSALLEGEYGISDLCIGVPAIIGAGGVERVIELKLDSFEQDVFNKGVASVKEAIKALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC98</accession>
    <name>K0IC98_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57165">
        <property type="protein sequence ID" value="AFU57165"/>
        <property type="gene ID" value="Ngar_c02170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02170"/>
    <dbReference type="HOGENOM" id="CLU_1067996_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-217-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="27108" checksum="F46C9CCFBA76F182" modified="2012-11-28" version="1">MIGATLFASGLGFTNGQQLATAQQQTEQQQNQTQDGNATTIANTTMTDTFVASGVITGTIQEAGGGQQTTTTAGNTTTTTAQSGNQTDNATQTAGGGTSTAPFLVGGDWTMNVESGNVTNFMANFTMVRIDGSEHHNHDITNFNVGNNTQFQLDPAGTTTINGTADYAVNGTSRWPGTDTVITIEKATVLTIQPQEQEAKDHFQGQPIYGIVLRATGENGTTITESVPAGGNQTQQQQEDGGGFLENLTRPFEDLFGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICG3</accession>
    <name>K0ICG3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59066">
        <property type="protein sequence ID" value="AFU59066"/>
        <property type="gene ID" value="Ngar_c21360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21360"/>
    <dbReference type="HOGENOM" id="CLU_3057249_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2134-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5955" checksum="2158DF468902010B" modified="2012-11-28" version="1">MPRGVKKGVSEKKFERAVRKIKRKGGAKNPYAVANAKLGRKGSRGRKMKESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICJ9</accession>
    <name>K0ICJ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57330">
        <property type="protein sequence ID" value="AFU57330"/>
        <property type="gene ID" value="Ngar_c03820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03820"/>
    <dbReference type="HOGENOM" id="CLU_2217133_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-382-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="11816" checksum="BA512F8BBF684F25" modified="2012-11-28" version="1">MSSALGSNNSSIKTVRIPNKLLKVIKYRARTEGIDESTAMRQLIAIGAKNYAVDMYRNGKLTLNDAAALTDMTVREMIDLLLDRGVTGNVRMDQQRKAIEFALKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICU6</accession>
    <name>K0ICU6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetolactate synthase small subunit</fullName>
            <shortName evidence="6">AHAS</shortName>
            <shortName evidence="6">ALS</shortName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvH</name>
        <name evidence="8" type="ordered locus">Ngar_c22410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22410"/>
    <dbReference type="EnsemblBacteria" id="AFU59171">
        <property type="protein sequence ID" value="AFU59171"/>
        <property type="gene ID" value="Ngar_c22410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22410"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2221"/>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_2"/>
    <dbReference type="OMA" id="EPYGIKE"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17623" checksum="CD01BC4BF0F08C22" modified="2012-11-28" version="1">MSALVENKPGVLFRVTNLFRARNFNIESITVGSTEQKDLSRMTITTNSDERTLDQLVKQLRKLIDVVEVKVLDTEKTVYRELALIKMKAVDPTTRSEIINYATIFRGNILDIGKETITVEITGTPDKIDAFKNLVEHYGIAQISRTGVSALPRGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICW3</accession>
    <name>K0ICW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57505">
        <property type="protein sequence ID" value="AFU57505"/>
        <property type="gene ID" value="Ngar_c05620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05620"/>
    <dbReference type="HOGENOM" id="CLU_1860762_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-560-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="1">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="16339" checksum="48C7183E53789952" modified="2012-11-28" version="1">MRNPERHSTIRYEKPVGIDVGITNYAYDSNGNHIDNPLFMSKELKPLRRAQRKVPRRQKGSKNYKKAVSWLQRLHMRIANKRKNFLHNLSTWYCRNYDLIFIYRKIKAAEYEQEPLSGKTHYGFKLGHFQANARVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID07</accession>
    <name>K0ID07_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23350"/>
    <dbReference type="EnsemblBacteria" id="AFU59261">
        <property type="protein sequence ID" value="AFU59261"/>
        <property type="gene ID" value="Ngar_c23350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2310"/>
    <dbReference type="HOGENOM" id="CLU_659899_0_0_2"/>
    <dbReference type="OMA" id="MYVTAML"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2333-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="416" mass="43637" checksum="8CA2A36E0158218B" modified="2012-11-28" version="1">MQRRAGPACSLSRSEIGSLEPTKERRQQQLSAKLVASAIIPLVVLGAMVTFLLWPGNGLLNFGIPLPDVAIERIEFLDGRIATHIRNTGPQAIEIAQADVNDRIMPAAIEPSKSLERFAEAKVVIPFNWIEGQPYEIGITTSDGTRFAKAVAAAAPTPQPDAGRISLFALLGTYVGVIPVLIGLLWYPFIKRLSMPKYSFFLSLTAGLLLFLGIDALVEANEISVENVAGVFRGQLLIATVAIVSFLALMYVSDRLVVVGNAKGRIVQGSFAIALMVAIGIGLHNLGEGLAIGGAMLVGEVALSTFLIVGFTLHNTTEGLAIVAPMAKEKPRISYLVALGIIAGAPAILGTWIGGFVASPVASIVFLAIGAGAVFQVVVAIGRFVSRSSGGKLLTGPTAAGFAVGILVMYLTALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDB3</accession>
    <name>K0IDB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c24620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59386">
        <property type="protein sequence ID" value="AFU59386"/>
        <property type="gene ID" value="Ngar_c24620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24620"/>
    <dbReference type="HOGENOM" id="CLU_1615362_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2460-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="18516" checksum="B8C9D4CA791DD970" modified="2012-11-28" version="1">MILLGDLSGIRDRSRGRRMNRIVANMPFYRLAQYITYKASWEDIPVITTKEWYSSKICHKCGSDNTSRPHQGLFVCHDCGYSCNADYNGAVNLGNRLAEHVFANGVIGFSALEQDDFLDSASQPKTWQNLQGFPLFPDCRAAHRSVSVALLLEARLTFRVSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDM6</accession>
    <name>K0IDM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57795">
        <property type="protein sequence ID" value="AFU57795"/>
        <property type="gene ID" value="Ngar_c08530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08530"/>
    <dbReference type="HOGENOM" id="CLU_2712961_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-851-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8105" checksum="1735466DF5E6ADBF" modified="2012-11-28" version="1">MKTHYILSFSIINMGQHGKHVFIVAAFAVVVDTIFPAIMLAFIAFACLVRIPDFRYRIVTQFASVLLQSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDR1</accession>
    <name>K0IDR1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57855">
        <property type="protein sequence ID" value="AFU57855"/>
        <property type="gene ID" value="Ngar_c09130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09130"/>
    <dbReference type="HOGENOM" id="CLU_1076056_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-911-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="236" mass="25891" checksum="91F9179B109353E6" modified="2012-11-28" version="1">MYLVGHAIVGFLIAYTISKKFKVGGISFALVMLIACLPDIDIIFQSLGIMSHKTYTHSLILSATIVPSIIFAIARWKKVSAVTAFVYSLAYVQHIIMGDIAVGSINILYPFGEMVVGSGIGYGTLAHQTIESLLLAAAAAVVLNRTFKKEQPDTVVLLRYNNIDKVSYLLLIGSLTVSFAYLLYGVKILPRLFIETDLELAVFIILHLSTMAWMSFTMLVARQSAILGSLKSTRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE21</accession>
    <name>K0IE21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/opine/nickel ABC uptake transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">appB</name>
        <name evidence="6" type="ordered locus">Ngar_c26900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26900"/>
    <dbReference type="EnsemblBacteria" id="AFU59611">
        <property type="protein sequence ID" value="AFU59611"/>
        <property type="gene ID" value="Ngar_c26900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2665"/>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="125"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="349" mass="38822" checksum="7BA78B78E05855C8" modified="2012-11-28" version="1">MGGFGRFLIKRSINMVIVLFATLVLTLALLGPTMDRVLLEAIRFYIVEEVNHSDIRFQTAEEREAFINNRIDLQVKNIGLDEPWYAPKRFINTVLKVMVLDLGKSSYLTSESGSVSVRDIILEKMPKTILLFTTSTLIVTIIGIYLGTYVANRAGSIWDRLNSAFAVFSGSFPTWWIGMLMIFAFAFTYHIFPARATPLTPPSDPAYALDLFYHMLLPLITIVLVSFGSWAYTVRYFVIGILGEDYIAAKRAAGISENRILYSHALKNAAPPIITVIALSLAGSFGGAITIEAVFGWPGMGSLYYQAIGFLDIPVIIGLTYISTLIFIITVFLTDIVYAYFDPRVKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE38</accession>
    <name>K0IE38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59621">
        <property type="protein sequence ID" value="AFU59621"/>
        <property type="gene ID" value="Ngar_c27000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27000"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2700-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="16204" checksum="F154390C2E1850E0" modified="2012-11-28" version="1">MKPFFQEFCDKVITLDKSIRFAGIADEDGKLMATAERKGLKPLLNPEERAQYAITAATRQYTRLRWEYLLGRINYAMSHYAKLIRATIPIADENSRLSYVLLLSFDVDGENVHNVIMKKIIPLVRKNMGKFLEEHTRTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE46</accession>
    <name>K0IE46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-alkenal reductase</fullName>
            <ecNumber evidence="3">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c27100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27100"/>
    <dbReference type="EnsemblBacteria" id="AFU59631">
        <property type="protein sequence ID" value="AFU59631"/>
        <property type="gene ID" value="Ngar_c27100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27100"/>
    <dbReference type="HOGENOM" id="CLU_020120_2_0_2"/>
    <dbReference type="OMA" id="DTRHFDY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2710-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="304"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="416" mass="43395" checksum="283F2E2956D14FE3" modified="2012-11-28" version="1">MKKTVQKQVAILAIISALLSSALAIQVVRDGGLALGQLVSPAMQTLPNINAGQSQQCSNKGTASTTTVSSSNASAILDAESAALNQVFKKAGGSVVQITSSVKTVIPNIIINGNPLEQQSTRLGSGFVYDTQGRIITNNHVVDGSKTVDVTFIDGNTYSAKVVATDAFSDIAVLQITDDFSSEHLTPLSLGDSSQLQVGQQVIAIGNPFGLSDTMTTGIVSQVGRLLPNEEMGFSIPNVIQTDAAINPGNSGGPLLDLQGNVVGVNTAISSSTGEFSGVGFAIPSNAVARIVPHLIQDGKYDHPWLGIAGTSLTPDLAEKMELPKDFKGVAIASVAPRGPADKAGIIGATRNDIPAGDVVTAINWHAVKRIEDIFFYIEEHTSVGDKVTITVYRDGHSKDLTATLQARPLPVMQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE61</accession>
    <name>K0IE61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58065">
        <property type="protein sequence ID" value="AFU58065"/>
        <property type="gene ID" value="Ngar_c11230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11230"/>
    <dbReference type="HOGENOM" id="CLU_2115556_0_0_2"/>
    <dbReference type="OMA" id="YSATLIC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1121-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12917" checksum="CE38A84462C9A322" modified="2012-11-28" version="1">MFKDGASTDAELKEALQGKTLKVYLTLLDSSEPIGAREMQRRLNYSSVNVAVHHLDKLCKVGLAAKDEHGRYFATKKVNIGIMDLFMNLGRIRFPRLLFYAAFFAAFSIISTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE80</accession>
    <name>K0IE80_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation protein TolB signature-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11440"/>
    <dbReference type="EnsemblBacteria" id="AFU58085">
        <property type="protein sequence ID" value="AFU58085"/>
        <property type="gene ID" value="Ngar_c11440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11440"/>
    <dbReference type="HOGENOM" id="CLU_2433958_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1142-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="9877" checksum="8F8C5382474953B9" modified="2012-11-28" version="1">MAGWLAAPVIAGLAVGVAFVLLFSFLLPTVASQQHDRVVFSSLMNRTDTYQLYIVNDDGTGLMKLTEDDGMWYFEPVSSPDGSKIVYVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEA2</accession>
    <name>K0IEA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58105">
        <property type="protein sequence ID" value="AFU58105"/>
        <property type="gene ID" value="Ngar_c11650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11650"/>
    <dbReference type="HOGENOM" id="CLU_1965631_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1163-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="15478" checksum="FA266259B05063FA" modified="2012-11-28" version="1">MLAYANHLGRSTTFFEIKRRDQIIAYLDRFVKREEEDPEKKWITTWNDTCHRIKHLFRWLYCQRGREETIPPSDWETPEFVKIKDKKTKRLSPYSETEIWDKDELLTIVKYEPIMVMGMHGILLLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEQ9</accession>
    <name>K0IEQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03250</name>
        <name evidence="3" type="ordered locus">Ngar_c03540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57273">
        <property type="protein sequence ID" value="AFU57273"/>
        <property type="gene ID" value="Ngar_c03250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57302">
        <property type="protein sequence ID" value="AFU57302"/>
        <property type="gene ID" value="Ngar_c03540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03250"/>
    <dbReference type="KEGG" id="nga:Ngar_c03540"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.314"/>
    <dbReference type="HOGENOM" id="CLU_945331_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-325-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="294" mass="32526" checksum="AC2174F5D3C9B798" modified="2012-11-28" version="1">MPNNKDDNLNKEKEEQPTEPTEPEQPTEPEQPEPITPASETKEVVTHEKESRQEEPNHAQTAKELLKPFAELIADKDKPRALKVREILKGLHEQGKVTLLGNDLYYAVRSELASIFGVTTQAIEKQARQVVEVGNRDTSDEPEFPNEPIGPKQPATETPAGGAPVGAPIGGFKATDSQTGEQIEAQEMMVWDKKKVGRIVALPINFGTLLSDAWVPLSKAEREELGDSFLQIFKDYLPTTKKTGSFLAAMAAMEMILMPRISGMFEARKQGADIEKVKEKVKAKIQEALGNDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IER4</accession>
    <name>K0IER4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29280"/>
    <dbReference type="EnsemblBacteria" id="AFU59846">
        <property type="protein sequence ID" value="AFU59846"/>
        <property type="gene ID" value="Ngar_c29280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29280"/>
    <dbReference type="HOGENOM" id="CLU_466635_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2928-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="584" mass="65060" checksum="185DC0DCB3F1FEBF" modified="2012-11-28" version="1">MNSFYSTLYGKFADLQVDQSFSARFAYPAKGLRPSLKIGKGILDCTVRIPQIRAAKGTISYGPFLFKDSEFGQAAAIRLAVASTCLLSGKSVFYWLYRDYLGEWLASKEDKIRAGYIVNVILDMLARQRIRQVEGEDFYADTMRHADLLVSALLPRHPKNFGILTQATLASFLLNISAAYAPTAIVKTAKNFISKLNAFAFDPSRLVDIIRDRISSNNNTVEISRAESGWDHIAKLADTLYAIIDKIPGKWHSVYLPYSNVLAVGNLESISIFESKIITEKEFTVIKRRAMNGSSNNNHAGDDTVWQEIFFELLREEKRNEKTLSRLSRATKNLNFSTVGFPTSDYVSYYSLYNELGPQIRRVIERVSLIKNALDENAFEESGSIDLQVAIQAVASETRRNDIFIKDENLLKNESWTILIDSSLSLSGSSRQLKAVSICLGETANQVMGSSNPWAMFAFSDEFYCIKDFTEPYDSQVKARIGGLAQNGLSHIPDAIRSCRALIGEHSKDRNYLILVSDGIPSGYLGIEAEFTASVKELGKYGINLAAIGMGGSAIKKAIRNARTIDTPADIVKEFIEIYQNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEU7</accession>
    <name>K0IEU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57318">
        <property type="protein sequence ID" value="AFU57318"/>
        <property type="gene ID" value="Ngar_c03700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03700"/>
    <dbReference type="HOGENOM" id="CLU_191135_0_0_2"/>
    <dbReference type="OMA" id="DMVFEVL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-370-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8501" checksum="7320615682CDE4CD" modified="2012-11-28" version="1">MLGSKEGVDDQFIGIIDDLVVMSENDSELAEGLKWIDAQSQKNGVTFYEMAMIILRKHMAERRAKEWLKNKLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEY8</accession>
    <name>K0IEY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57363">
        <property type="protein sequence ID" value="AFU57363"/>
        <property type="gene ID" value="Ngar_c04160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04160"/>
    <dbReference type="HOGENOM" id="CLU_2875198_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-415-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7069" checksum="268B1E8E55A15C7B" modified="2012-11-28" version="1">MFLITAFVAMPSNPDEITAPMDLVIGFRLASRFTMSIFWGLLGLILGAFWDRIKPHDTAKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF11</accession>
    <name>K0IF11_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59946">
        <property type="protein sequence ID" value="AFU59946"/>
        <property type="gene ID" value="Ngar_c30300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30300"/>
    <dbReference type="HOGENOM" id="CLU_309433_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3030-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="952" mass="100859" checksum="4199551E000A3E07" modified="2012-11-28" version="1">MILPQNFSVVAILLAIVIVATIFSPLSIARALASDVGNNDIRRTSGNYIINYVYEIEVEKPKLSVDKPKVAQGGSITIKGTNFANSTVSIQAFDEKLLIFKENGDKQNQTAGLLLTRSDIALAQPAVGKASVMKKFAHDNNNSIQDSNGTVTLVIKAPSEGAQNYSADLQCKSMPGSSMREDPLIISLGSGTVNGSSRQFVNASLPAGDYQNCEIVVTLPETGKTFRSESFDFAVVPDAYAKPDGKAVVAASNGSFQLRVSLHNNIQPGKYVFMAEEQLKDDDDDNNDAKRQPARAIVPIQVVAKQYTSTTTTHTSIESIQESIVEGSVQSSNRSTTTSTDMTNSNDNVSNDHQGPDNNGNNDNNGSGGGGEQPPTTTSPSDDGPKEVCTTDDFSFESPNDASHTNTILQTSIQTANNAIINDDVITITQRIIGATNASQNVIMSVDIRNDNEVMQSIRQNIVQEAEIEHCQTVGEVDGDGVDGSGGVRATNTTNLVLSAALQEAYNIYSDSDVIQIQQTIIIPKYCSANVYAPITMDDRNRISQLIDQDIVQKSKIKFTTDGSTAGQGRSAADNAGQYSYLQKNYITQLSIQGASNIALDNNVININQAIIVPASCEADVYAPTVVRSSSDIQLSIIQKAEQVSTIQQLAGQQPGITIANTISTGNNSSQAVGGSVFTNTIINHAEQYGENLFIDNDNLQVVQQVFFVNDTTGWTLDNYQDKLAEEFGDSGNNSDNSTSSSSLIATGNQTSDAPLDAADDTGDNNNDTALAEEETETADNTSSGNDTASSADNNISSDPTAATTSNTTTIVQQSGLQDASNYNQNNSTINVNQDAEGYQIDTAASVHDTNDGEQANGQAQEQDAAIASDSDMPAGDDNSTSTVENGIEQTGVQLATNYSGENNETTVDQGALGNQVNAGIEVANENNLAQSDGQDQSQEATITTGGNSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF31</accession>
    <name>K0IF31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30500"/>
    <dbReference type="EnsemblBacteria" id="AFU59966">
        <property type="protein sequence ID" value="AFU59966"/>
        <property type="gene ID" value="Ngar_c30500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30500"/>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_2"/>
    <dbReference type="OMA" id="CQHNAHM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3050-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="385" mass="42291" checksum="D50DB7DB4F047AF1" modified="2012-11-28" version="1">MALTTHTVSSNMIPINKPWIGEEEKREVASVLEENALTTAARDGGRRVRDFESQMKSYLKAKHVVSVNSGTAALHAALMAAGIKQGDEVLIPSFTFVATANAVVAAGGRPVFVDVKKDDYTIDVSDLKKKITKRAKVVIPVHLYGHPSDMDEIGELADKHALDVVEDACQSLGSTYKKKQTGTFGVMGCFSMYASKVLTAGEGGAVATDSDELADRLKMIRNHGMVEGYDTRVLGLNLRLPELSAAVAKVQMQKLDKMLQIRRRNAELMSKLLFPSAKKHGIKIPEETADKKFNWYLYTVAFQNGSRDRIKNALVKDNIGATIYYNPPAHKTPYYMQVAPKTSLRATDWCADHVLSLPVHPYVSEADIDHIASSLKAVLEKSNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF49</accession>
    <name>K0IF49_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58410">
        <property type="protein sequence ID" value="AFU58410"/>
        <property type="gene ID" value="Ngar_c14740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14740"/>
    <dbReference type="HOGENOM" id="CLU_2519877_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1472-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9042" checksum="CB928E226F0C5132" modified="2012-11-28" version="1">MFAASGGSGTERVSSIVTIPAGSSSGNKNFEPEVIKVIIGVNNTVRWINKDDVPNAVVASNDDDSVFQYHQRKRTQHLGAGWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF82</accession>
    <name>K0IF82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58455">
        <property type="protein sequence ID" value="AFU58455"/>
        <property type="gene ID" value="Ngar_c15210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15210"/>
    <dbReference type="HOGENOM" id="CLU_3021090_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1519-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6618" checksum="CDD8864608E06A99" modified="2012-11-28" version="1">MPGLEFITNIAGFIRWRIQNCNYIMKYKTIIEFRNSKLYLYFKMIFQSSIDAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF89</accession>
    <name>K0IF89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58465">
        <property type="protein sequence ID" value="AFU58465"/>
        <property type="gene ID" value="Ngar_c15310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15310"/>
    <dbReference type="HOGENOM" id="CLU_2985799_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1529-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6482" checksum="A65EB24954A58616" modified="2012-11-28" version="1">MVQLEYVNPLAGLAMLVIGLFLIWFGYWVYGITPAVVGIVLVIYYRKYLLQIMGMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFB5</accession>
    <name>K0IFB5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58500">
        <property type="protein sequence ID" value="AFU58500"/>
        <property type="gene ID" value="Ngar_c15670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15670"/>
    <dbReference type="HOGENOM" id="CLU_1425128_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1565-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="190" mass="21947" checksum="FCED30EBA1AC5040" modified="2012-11-28" version="1">MQNAPRFRWNKDLCCLIHDRESGKTTVALDLAKRVPKTKIIVLNSNFEHAYRDIAYKIVKPKFYTTEILDAFIKYLRQHVNVLGIIDDIDLYKPQYSMQLESLAINGRHQNVGLIIMSRRVVGLPKTFCKCVDLLYCGYTNAKSDLETISEYFDAKVAQVVPTLPRKYKFARWSKKDPDNIVIIESGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG05</accession>
    <name>K0IG05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07960"/>
    <dbReference type="EnsemblBacteria" id="AFU57738">
        <property type="protein sequence ID" value="AFU57738"/>
        <property type="gene ID" value="Ngar_c07960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07960"/>
    <dbReference type="HOGENOM" id="CLU_2875202_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-794-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7219" checksum="CAF97D8A41301DE4" modified="2012-11-28" version="1">MHRRQDRQTLVIILNQVGKNFSSQNNHISSSHFDFAGINIIQPKLKVSRPNDKYELEADAIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG33</accession>
    <name>K0IG33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dolichol-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dpm</name>
        <name evidence="9" type="ordered locus">Ngar_c18120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18120"/>
    <dbReference type="EnsemblBacteria" id="AFU58745">
        <property type="protein sequence ID" value="AFU58745"/>
        <property type="gene ID" value="Ngar_c18120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18120"/>
    <dbReference type="HOGENOM" id="CLU_039727_0_0_2"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="253"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="378" mass="41705" checksum="7F0E8D85BFDC5C3E" modified="2012-11-28" version="1">MPLSIVLPTYNESQNIAKMLDSIAEALPADTAAEIIVVDDNSPDGTGDIAAQHAKNISNKKVRIEVIRRPGKMGLSSAILAGVQSAAGEIVVVMDGDFSHPPQTISHMLEELQDPKCDIVVASRYVKGGSVIGWPFKRRLMSKSATKIAQVGLGIEVKDPMSGFFAFRRRIIEGVKFDAIGYKMLLEILVKAKGARVKEVPYTFTNRRAGASKLDSSVMFDYLRAVWRLYRYGKSLREKERRASVRFLSKAARFYTIGATGLLVNYAATTLFVGLLPGIWILYAAVAGIVFSITSNFFLNKLWTFEDRDFTANTTLVQYGLFAGFSSPGAAIQLSMLYMLHGSQQVSYPVALVLAVMVAAVGNFLFNKKWTFKEKIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG37</accession>
    <name>K0IG37_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease HII</fullName>
            <shortName evidence="10">RNase HII</shortName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">rnhB</name>
        <name evidence="13" type="ordered locus">Ngar_c34560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10 11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 10 11">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34560"/>
    <dbReference type="EnsemblBacteria" id="AFU60371">
        <property type="protein sequence ID" value="AFU60371"/>
        <property type="gene ID" value="Ngar_c34560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3455"/>
    <dbReference type="HOGENOM" id="CLU_036532_0_4_2"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="12">
        <location>
            <begin position="15"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU60371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="24827" checksum="296C20421204FA67" modified="2012-11-28" version="1">MNNLRSLHDGVLVGGVDEAGRGSIIGPLVVAGVSIKESKVALLTEMGVRDSKALTPRARARLFGQIMKIADSVCIRKVNPVEVDDSVSLRALNRLEARVMAAVINDIGADEVYVDCCDINPDRYKDYIGQHLKCSPKVHSIHHADVTNVVVSAASIIAKITRDEEIKRIRSKYRGIGSGYPSDDRTMRFIRRYVAKNGSAPEFARKSWKPLRLLLEQTAQCKLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGB5</accession>
    <name>K0IGB5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57868">
        <property type="protein sequence ID" value="AFU57868"/>
        <property type="gene ID" value="Ngar_c09260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09260"/>
    <dbReference type="HOGENOM" id="CLU_027402_15_4_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-924-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="13778" checksum="7E6474849ADCEB81" modified="2012-11-28" version="1">MSSEIEETRFNIIHEHERTRESITEICSKHGISRNTYYKWKNRYLVQDINGLKDRSRRPHTIRNEKVTPEIEQVILSLRLENRFGTARIKFRLKKRLGVSLSSRTVYRVLKRHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGF6</accession>
    <name>K0IGF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58885">
        <property type="protein sequence ID" value="AFU58885"/>
        <property type="gene ID" value="Ngar_c19530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19530"/>
    <dbReference type="HOGENOM" id="CLU_2103590_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1951-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="14922" checksum="655A7760A6B061C8" modified="2012-11-28" version="1">MVGWRYIDAAGISVLQSATYRASRQKHWEVFKMHSTHKESKNVLLAVVEEAKRGVNKERLPIEKSSAQVPRTTIPLLSKLNDSEKHRAAKMAAIAVEMDGEIHFMQVNRMVPETAKIVRDSTGRFVGLPAVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGH0</accession>
    <name>K0IGH0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57928">
        <property type="protein sequence ID" value="AFU57928"/>
        <property type="gene ID" value="Ngar_c09860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09860"/>
    <dbReference type="HOGENOM" id="CLU_2127912_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-984-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="13017" checksum="CE225ED09833836F" modified="2012-11-28" version="1">MRKKSTAGDSPPSSFERTTIFFTDEQDMAFLKDDAIFSDTFNSRRKAVDELAKRYKQRAIPVIREIIDACSTLKGQEDNDVFIRYCQMFIEELLESSKTASRRNNNSNSKSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGL9</accession>
    <name>K0IGL9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c10310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57973">
        <property type="protein sequence ID" value="AFU57973"/>
        <property type="gene ID" value="Ngar_c10310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10310"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.981"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="NEYQDEH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1029-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="163"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="274"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="376" mass="44331" checksum="6BC8829BE2AF390A" modified="2012-11-28" version="1">MTLNYKFRLYPTKEQELVLEQTLDGCRWVYNYFLDKNMSSEYDMNYALTELKEQHPWLRNYHSKMLQMIAKQVAAARKTAAKGILSYRKHNDFNAFTYNQSGFRLENNKLSLSKIGSIRIVLHRKLPVNVKQVTVCRSKTGKWYAVVACDVLRRLYSTIIYRKPVGIDVGIAKFCHDSDDHTEDNPQFLTKMLRPLRRAHRRVSRRQTGSSNYKKAKHMLARLYERINNKRRDFLHKTSTYYSNRYDLIFLERLRVMNMAKNHRLARKILDASWSTFKNMLQYKANRVVEVEPAYTSIDCSRCGHPVPKSLAVRTHACQKCGAVLDRDYNASINILQRGLESLMLLLLPVERREVTPVEIAMQSRKQEEAYEFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGQ7</accession>
    <name>K0IGQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59015">
        <property type="protein sequence ID" value="AFU59015"/>
        <property type="gene ID" value="Ngar_c20840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20840"/>
    <dbReference type="HOGENOM" id="CLU_2379505_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2082-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10693" checksum="2D086E62EC70F6F8" modified="2012-11-28" version="1">MLLKKESSSDKIILRRGSVGNDQDGTPLLINDRGEAYRVNDTAVSLWNMCNGITFDDLFLEVLRISSDSESEVKKSLEQMIKQFQKISVIELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGY1</accession>
    <name>K0IGY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11680"/>
    <dbReference type="EnsemblBacteria" id="AFU58108">
        <property type="protein sequence ID" value="AFU58108"/>
        <property type="gene ID" value="Ngar_c11680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11680"/>
    <dbReference type="HOGENOM" id="CLU_2021576_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1166-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="14062" checksum="E396DE87509A52ED" modified="2012-11-28" version="1">MKDNGSQENIHEIMAHAELDLQSIKRAIGETTLKESLISRDDNYHRKIDWNVAKRFLNIIYLHGPIRKTRLAMKTGVNSTTCTKYVTWLIEVDWIDVNDCDEFRLTQAGLAVSKRINSEDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH99</accession>
    <name>K0IH99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13050"/>
    <dbReference type="EnsemblBacteria" id="AFU58243">
        <property type="protein sequence ID" value="AFU58243"/>
        <property type="gene ID" value="Ngar_c13050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13050"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="OMA" id="MIMTAFE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1303-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="14148" checksum="45A7D3318C9BFDC7" modified="2012-11-28" version="1">MQQRVRIMAVDDEPDILNIVKMSLAKWGYEVDAFLDPVVALDHFSQNASAYSLILTDIKMPGMSGEELARRARQTRPDVKVMIMTAFEVDKALKESLPSIEKDGFLQKPFHTTDVCVAVKKHLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE3</accession>
    <name>K0IHE3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57187">
        <property type="protein sequence ID" value="AFU57187"/>
        <property type="gene ID" value="Ngar_c02390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02390"/>
    <dbReference type="HOGENOM" id="CLU_210073_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-239-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6871" checksum="058E7FA716DE9F04" modified="2012-11-28" version="1">MVKSMDKREYDQLDSLSSSPNAEISRLSIIVKNLKDRVESLERNQTELMDKLNALKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHL6</accession>
    <name>K0IHL6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c14670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14670"/>
    <dbReference type="EnsemblBacteria" id="AFU58403">
        <property type="protein sequence ID" value="AFU58403"/>
        <property type="gene ID" value="Ngar_c14670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1431"/>
    <dbReference type="HOGENOM" id="CLU_072493_0_1_2"/>
    <dbReference type="OMA" id="TYFNYLW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1465-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="4">
        <location>
            <begin position="117"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="331" mass="37249" checksum="E55F4842FC38E51E" modified="2012-11-28" version="1">MSISDRSRKAMENLGLTSYEIRVYLSLLDSGAMTAADISKKSGVPYSKIYEVLNSLEEKGWLESDSSRPQKFFPKSPSSALEAMRMRHENNFRESQSTIVNELMPMYTKSGMKERPEIWVARGVFNIVAKVNEIVQNARQELLVALPFVAVDVAKPLQPVLRTLHDKGVKIHILASAKITPETIKALSRVAEVRLKDGLFGGGVIGDGKQVVLLLGEGTGDGGSFEPIAIWADHAGLAGFAKGYFQYLWEDSAEKKKSKKRRYMRRDKVNRVWREQIARGDCRCKEKANRLRGRAFCRHGRVRARRDVPEGHMVHPRKRRGSQGKLDSQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS6</accession>
    <name>K0IHS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57402">
        <property type="protein sequence ID" value="AFU57402"/>
        <property type="gene ID" value="Ngar_c04560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04560"/>
    <dbReference type="HOGENOM" id="CLU_3178699_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-455-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5114" checksum="5CA662959D815674" modified="2012-11-28" version="1">MGQLLQHGFGQEVAMIVRMPYLLSDPSELFSLVKTSGFGEIVMKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT9</accession>
    <name>K0IHT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57442">
        <property type="protein sequence ID" value="AFU57442"/>
        <property type="gene ID" value="Ngar_c04980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.477"/>
    <dbReference type="HOGENOM" id="CLU_2044483_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-496-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13005" checksum="1C041AE07249152F" modified="2012-11-28" version="1">MHNPIEEMDDEVSSQKKKSFEVIITALNMAAMGAGIAAAVIAASKSKAASADAGKIEKSISDLSAKFDKMSEQLKSIQPEVNNNTTTKEVDKKPEGAAQPHNKPQDVIYVRKSSEFSFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHW2</accession>
    <name>K0IHW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16050"/>
    <dbReference type="EnsemblBacteria" id="AFU58538">
        <property type="protein sequence ID" value="AFU58538"/>
        <property type="gene ID" value="Ngar_c16050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16050"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1573"/>
    <dbReference type="HOGENOM" id="CLU_137908_1_0_2"/>
    <dbReference type="OMA" id="PAYLCWK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1603-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="15479" checksum="8857D249F5554989" modified="2012-11-28" version="1">MFTLFTPQTANKALPEVRRLFSNILMYKKQAVALQEQVEMIIQSGSQFEQFVKKKQELNTAVSNYYKAIEQLEATGVVIKDIEQGLLDFPSKRFDEEVWLCWKVEESEIKFWHAKDEGFMGRKPLESTGIIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY0</accession>
    <name>K0IHY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59540">
        <property type="protein sequence ID" value="AFU59540"/>
        <property type="gene ID" value="Ngar_c26180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26180"/>
    <dbReference type="HOGENOM" id="CLU_119856_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2618-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="17955" checksum="713340C7BFDB978E" modified="2012-11-28" version="1">MAERLKDIKETASDAVEIIRELGSPDVQESLEKIREVAKTAREIIESLKDPAMVENIENMRKMAESIENTGARMEKVTTELRNSGVLDEAKETMKSARGTISSMGDAKNMGETVDAIKEMLRSISGLIDELKLTVVSSKKEGVIHDAEEAVRETRNALGGHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY4</accession>
    <name>K0IHY4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58553">
        <property type="protein sequence ID" value="AFU58553"/>
        <property type="gene ID" value="Ngar_c16200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16200"/>
    <dbReference type="HOGENOM" id="CLU_2875205_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1618-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7590" checksum="6F071B3B603F622B" modified="2012-11-28" version="1">MLTEHERNPFCYICNLFFTPDYMPIHLKTDHTKEELASHLLLAYFDEWLEQEEAIEEAVESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY9</accession>
    <name>K0IHY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative GAF sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06040"/>
    <dbReference type="EnsemblBacteria" id="AFU57547">
        <property type="protein sequence ID" value="AFU57547"/>
        <property type="gene ID" value="Ngar_c06040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.577"/>
    <dbReference type="HOGENOM" id="CLU_1500240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-602-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="21042" checksum="FFB26C8D903183CA" modified="2012-11-28" version="1">MQDKIDELILSALSKNSKQDVREIWDFLRDFGFNLSEDEIESRIARLEEEGVITGYTISVNTRKIPKRVIRVVLVTFRTSQHLPKRIEGLKKYLADAPFVLFSGRTRGGYDWICVQSFPSEEMADEESDIYRNLFGDIIQSYEVYDFIPLKDPSFHSLAYTDKEYKKFLDEWIPPFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0II90</accession>
    <name>K0II90_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c07540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07540"/>
    <dbReference type="EnsemblBacteria" id="AFU57697">
        <property type="protein sequence ID" value="AFU57697"/>
        <property type="gene ID" value="Ngar_c07540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07540"/>
    <dbReference type="HOGENOM" id="CLU_079909_1_0_2"/>
    <dbReference type="OMA" id="GVSQPHW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-752-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU57697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="21520" checksum="F30051EC2E8D101A" modified="2012-11-28" version="1">MADPFAISSTFFEDLIISTVALFVVIDPIGIVPVFMALIQKMERAERASVTKTAIITAAGLLFAFAVAGTQLLSIFGITLSSFMVAGGILLFIVAIELLTHGEWRFGGTSAQGESGVVPLAFPLLAGPGAITAVIISFQTAGLAVTAISILIVIGITYVILKYVGKIYRVLGRRGSIIITRVFAVLIAAIAVQYVVDGVRELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA5</accession>
    <name>K0IIA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57737">
        <property type="protein sequence ID" value="AFU57737"/>
        <property type="gene ID" value="Ngar_c07950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07950"/>
    <dbReference type="HOGENOM" id="CLU_2730537_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-793-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8092" checksum="E9A80B7F7469013C" modified="2012-11-28" version="1">MQKTTIAERVKMVSGFCSRNKIEYLTYHAPIFVNGENICDEKWGGIILDSIMQNIEEAKEVIDDPGLQTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG3</accession>
    <name>K0IIG3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-ribbon RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18760"/>
    <dbReference type="EnsemblBacteria" id="AFU58808">
        <property type="protein sequence ID" value="AFU58808"/>
        <property type="gene ID" value="Ngar_c18760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18760"/>
    <dbReference type="HOGENOM" id="CLU_196471_1_0_2"/>
    <dbReference type="OMA" id="KCGFEGP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1874-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="PTHR40733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6744" checksum="BAE59D148F80557C" modified="2012-11-28" version="1">MSKPLQLPVCTSCSRPIMPNDECVKYYCPNCGYVLIWRCESCREFARPYKCVGCAFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK7</accession>
    <name>K0IIK7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58893">
        <property type="protein sequence ID" value="AFU58893"/>
        <property type="gene ID" value="Ngar_c19610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19610"/>
    <dbReference type="HOGENOM" id="CLU_2930314_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1959-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6869" checksum="FAF670FA4FDB4DEB" modified="2012-11-28" version="1">MLQALKTTIHAAIFSKASHTIFRQHFLNFLPLPHGHGSFLPTFVFPELWPFDLGEGVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS6</accession>
    <name>K0IIS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative CRISPR-associated protein Cas1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="8" type="ordered locus">Ngar_c29420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29420"/>
    <dbReference type="EnsemblBacteria" id="AFU59860">
        <property type="protein sequence ID" value="AFU59860"/>
        <property type="gene ID" value="Ngar_c29420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2917"/>
    <dbReference type="HOGENOM" id="CLU_3178704_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5625" checksum="4BB1097DDF44ED2A" modified="2012-11-28" version="1">MFKPIIVDRVIFSLINNRIIKDEHFVEELNYCYLNEQGRLTFLSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV8</accession>
    <name>K0IIV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58057">
        <property type="protein sequence ID" value="AFU58057"/>
        <property type="gene ID" value="Ngar_c11150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11150"/>
    <dbReference type="HOGENOM" id="CLU_2597862_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1113-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9089" checksum="7239224B2B86B38A" modified="2012-11-28" version="1">MANMLDDSANDATDIDAKIAYHQEMEHIAIQSGDFTKAEHHRRMEELYVKMKKQQNSSSAQAAAKKDRRDLELARKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ16</accession>
    <name>K0IJ16_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58137">
        <property type="protein sequence ID" value="AFU58137"/>
        <property type="gene ID" value="Ngar_c11970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11970"/>
    <dbReference type="HOGENOM" id="CLU_2379503_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1195-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="9825" checksum="03B2C59A627D8BA0" modified="2012-11-28" version="1">MRSGIGIGLLSGAKNKKVITIVGAVMIVIGIGGMIAVGSQAADILSTRGVFGNPDLARSYFYGEYVFLFVMVAGLALTIFGVVSMQRKKKPASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ55</accession>
    <name>K0IJ55_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpl31e</name>
        <name evidence="7" type="ordered locus">Ngar_c12770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribosomal protein L31e family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12770"/>
    <dbReference type="EnsemblBacteria" id="AFU58217">
        <property type="protein sequence ID" value="AFU58217"/>
        <property type="gene ID" value="Ngar_c12770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12770"/>
    <dbReference type="HOGENOM" id="CLU_112570_3_0_2"/>
    <dbReference type="OMA" id="KEFATHH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="14937" checksum="39C78333AD66DAB4" modified="2012-11-28" version="1">MATVEENLTRVYTINLGRAWLTPEHKRTDRVINMIREFATKHMKSDEVKLEQDLNRQIWSRGKTNPPRKVRVKMVKDEDGVVTVSLYEDVPAATEAPAAAEEEEKKPEAASVETATAVAAEEPKAEESKSQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH8</accession>
    <name>K0IJH8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative inositol-1-monophosphatase</fullName>
            <ecNumber evidence="1">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.25" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32550"/>
    <dbReference type="EnsemblBacteria" id="AFU60170">
        <property type="protein sequence ID" value="AFU60170"/>
        <property type="gene ID" value="Ngar_c32550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32550"/>
    <dbReference type="HOGENOM" id="CLU_044118_5_0_2"/>
    <dbReference type="OMA" id="RWGDERY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3255-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24144" checksum="EEDD0E734CD8DC1A" modified="2012-11-28" version="1">MSRRIDLIAEKTVIDILRKRGIDATIIGEECGRIEGKRGYIIMDAIDGTTNAVRGIPFYCCSIAYATDFRLSTVTDAAIIDLARGDLYYASKGKGAFLNGKRISAKKESPADPAIGINISGVKPTVIERLAPIIAEADHTRQFGANALEMCFLARGLLDAYIDLRGKIRPTDIAAGYLIAKEAGAKAYSDSGSDLESDLDVKTRLSYMVVANDGMRERLAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK9</accession>
    <name>K0IJK9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60215">
        <property type="protein sequence ID" value="AFU60215"/>
        <property type="gene ID" value="Ngar_c33000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33000"/>
    <dbReference type="HOGENOM" id="CLU_176747_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3300-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8803" checksum="FFFCB2E4A331DB76" modified="2012-11-28" version="1">MVSEQGGVSGERKEVDVKDYPKAAAIGQILKDLDFPADKKKKERTGRATPQSEEILPDLQRIEERQYGSVSDVTKATGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJS8</accession>
    <name>K0IJS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25560"/>
    <dbReference type="EnsemblBacteria" id="AFU59478">
        <property type="protein sequence ID" value="AFU59478"/>
        <property type="gene ID" value="Ngar_c25560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25560"/>
    <dbReference type="HOGENOM" id="CLU_145186_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2555-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="16525" checksum="AC4CE7D424185B86" modified="2012-11-28" version="1">MSRKTKTKGRAAASKLKSRAKLRAKKAVSARKSSAKTRKKAATAKTKAKSASSAGKKIVRIMGHGQFTVDGKILKKLNDIDNDLVKLVSTERSDDSEFKKKLTELNDMVVKNGKPLDPHEIIKSDIILPSADLSIDEAKRLFRGEGVIPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJY5</accession>
    <name>K0IJY5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59538">
        <property type="protein sequence ID" value="AFU59538"/>
        <property type="gene ID" value="Ngar_c26160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26160"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2616-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9875" checksum="409C3C8871D766A2" modified="2012-11-28" version="1">MKYRSRTDITAQILEAANGGVTKTKIMYKAFLSYAQLKEYLTVLVENKLLEYIEGEQIYKTTDKGNRFLKIYNQIGEYVAPDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK11</accession>
    <name>K0IK11_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c35520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60465">
        <property type="protein sequence ID" value="AFU60465"/>
        <property type="gene ID" value="Ngar_c35520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35520"/>
    <dbReference type="HOGENOM" id="CLU_862261_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3553-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="230"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="322" mass="36351" checksum="3180AB0651869CBF" modified="2012-11-28" version="1">MGAAIIPVLVGLAAGIAFVLLFNYFVTTQPAGAYYVYEAPQSYEVLPGIKPISLLAKDPEEIATVIANAEDDEIVSEKRGDGGQAMTRLYATRNGGEIAISREMIPECRSGCDYLITYSTNSSIGPDVGFPITEQQALDYAESFLERSGYQLNKHEIFDVDYEPDDRFGKMVQVYQIIDICSHVQPREEGGAICKAEGFAADFHFLSDNTIIQLGMWYDESDVRNYEMRVSLEEAEKIAREHMDLQLRTHSDLRFRSYLYEFDRASADRTMMFISSTGQLLYNVEVRYKTSEIWHCTPYRGFHVMVDAGSGEVTHSRSFTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK47</accession>
    <name>K0IK47_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59603">
        <property type="protein sequence ID" value="AFU59603"/>
        <property type="gene ID" value="Ngar_c26820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26820"/>
    <dbReference type="HOGENOM" id="CLU_1607210_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2682-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="18494" checksum="E387F8E51C311E6A" modified="2012-11-28" version="1">MASEDKTDTYEETVTRTTSEPPTEVTVRGERVVTTSSSSDELQTAAPKKEEEESVSVKAREAGRSLKDLVYSLGRKTKEVTEEKARELKAQSVDVGATTDARDIQHLGEDVEKLITVFEDTMTEIRKEPYDEQEKLLVGYKKLLEEQINVINARMAMAKRLKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK73</accession>
    <name>K0IK73_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8p</name>
        <name evidence="4" type="synonym">rps8</name>
        <name evidence="6" type="ordered locus">Ngar_c17440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17440"/>
    <dbReference type="EnsemblBacteria" id="AFU58677">
        <property type="protein sequence ID" value="AFU58677"/>
        <property type="gene ID" value="Ngar_c17440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17440"/>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_2"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_S8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15209" checksum="06275647878A99E8" modified="2012-11-28" version="1">MKYEVPALNVLSNLFTTIYNNESRRKRECVIVPASKFASEVLRVMQKHRYIGEFEQVDDGRAGKFRVQLLAKINKCGIITPRFSVKKDAYFGWERQFLPAYSMGILLVSTSKGIMSHHEAISEGLGGVLVGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKD0</accession>
    <name>K0IKD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58837">
        <property type="protein sequence ID" value="AFU58837"/>
        <property type="gene ID" value="Ngar_c19050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19050"/>
    <dbReference type="HOGENOM" id="CLU_2243946_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1903-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11770" checksum="5EAA8A4DF6FDD7E6" modified="2012-11-28" version="1">MLYDGDDGEGLGLSSIQHPACQVAGCFEPASVYVVIKESDVNVLNLDAQERQMIMEKDAPAADVNAFKLILYLCARHDYDLKYLLKENELEITKRRHLVLKETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS1</accession>
    <name>K0IKS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GvpG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59132">
        <property type="protein sequence ID" value="AFU59132"/>
        <property type="gene ID" value="Ngar_c22020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22020"/>
    <dbReference type="HOGENOM" id="CLU_2550382_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2200-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9247" checksum="A81A536B2DBCF1A5" modified="2012-11-28" version="1">MKLTLDAILQHCNSLAYEQEVREQARVLKARLLKLMSDYEAGVIDQKIYSTQEAEIMASLSKLTQQVNNKSKTQSFNTGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL25</accession>
    <name>K0IL25_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thiamine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c23520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23520"/>
    <dbReference type="EnsemblBacteria" id="AFU59277">
        <property type="protein sequence ID" value="AFU59277"/>
        <property type="gene ID" value="Ngar_c23520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2326"/>
    <dbReference type="HOGENOM" id="CLU_053822_0_0_2"/>
    <dbReference type="OMA" id="CIDCHAN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2350-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="315" mass="34728" checksum="DA8BF0BED5541C58" modified="2012-11-28" version="1">MMLEQGVDVEAVAIKTPFCDFDCGKGCGHRVKEVADELGIKLKTVYFGEEYLRMLKNPKHGYGSGMNPCIDCRGMMYNAAKEHMEKTGADFVITGEVLFQRPMSQNNRALHIIESETGMEGKVLRPLSAKHLPPTDAEKSGLIKRENMGDIKGRSRKGQLELAKRFGMAEPPNAAGGCLLTDPAFSKRIEDIMDHCSDIPSLNDIELLKVGRHFRLTPDAKLVVGRNKDENEVIRALVTEGDVVIEAKDHVGPTCILRGKHDNKILAKCAAIVLRYSDAPKDVESKVRIIITADDREMETTAVPAESSAVDALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL49</accession>
    <name>K0IL49_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c32370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32370"/>
    <dbReference type="EnsemblBacteria" id="AFU60153">
        <property type="protein sequence ID" value="AFU60153"/>
        <property type="gene ID" value="Ngar_c32370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32370"/>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OMA" id="REDQQIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3237-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10746" checksum="5F115005B2B463F8" modified="2012-11-28" version="1">MSDFDSMDDLIKEIERGEANIVITKDVRKFRKPVTVVSGLQENKNAKDVTRQLKTKIGTGGTFKDGQIILQGDHRETVKAMLVEMGFKEESIEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB0</accession>
    <name>K0ILB0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC uptake transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c00290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00290"/>
    <dbReference type="EnsemblBacteria" id="AFU56979">
        <property type="protein sequence ID" value="AFU56979"/>
        <property type="gene ID" value="Ngar_c00290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.32"/>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_2"/>
    <dbReference type="OMA" id="HHVFGYL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-29-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU56979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="303" mass="33515" checksum="FEC9F2763BC79BF4" modified="2012-11-28" version="1">MLATIYTGSRPSQQQGSSQEQDKITVVASFYPLYEFASRVGGDRAEVSSLVPAGVEPHDWEPTPQDRQRVQSASMLVINSAGFESWADDMEANIVVNTSEGIELEHDDEGEGEEEDNDEHGHEGGVNPHIWLDPVLAKHQVEKIRDAMVSADPANANYYMEDADRFAAELDSLDAFIELELADCGKSDFVAFHDAFAHFAERYGLTQHSIHGASPEGEILPQRMQEIIELASELDINVIYSEDLIDSRLADTIAGEIPDGRVLVLSPIEGIDREEQQAGIGYIDKMKENVADLKVGLECRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILC3</accession>
    <name>K0ILC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase, small subunit</fullName>
            <ecNumber evidence="4">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c24990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24990"/>
    <dbReference type="EnsemblBacteria" id="AFU59422">
        <property type="protein sequence ID" value="AFU59422"/>
        <property type="gene ID" value="Ngar_c24990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2478"/>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_2"/>
    <dbReference type="OMA" id="VYTGLHQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2498-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15426" checksum="1E857E79B0401C34" modified="2012-11-28" version="1">MSAQQQQTRPIRVLVSKLGLDGHDRGALVICRAFRDAGMEVIYSGLFCTPEQVANMAIDEDVDVVAMSLLNGAHLTLFPKVARLLKEKGADDILIMGGGIIPESDRKELEKHGVTGNFGPGTPLPVIIKHITENLQQKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD9</accession>
    <name>K0ILD9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57019">
        <property type="protein sequence ID" value="AFU57019"/>
        <property type="gene ID" value="Ngar_c00690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00690"/>
    <dbReference type="HOGENOM" id="CLU_2857202_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-69-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7552" checksum="4041D8E0BDF710BA" modified="2012-11-28" version="1">MKKNIQAVLKRDDGRIVREAKLKKQADQILQFLKGTDAAVVMESGYNYQFLYDLLKERRTMMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL2</accession>
    <name>K0ILL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter, periplasmic phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstC</name>
        <name evidence="5" type="ordered locus">Ngar_c35750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35750"/>
    <dbReference type="EnsemblBacteria" id="AFU60488">
        <property type="protein sequence ID" value="AFU60488"/>
        <property type="gene ID" value="Ngar_c35750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35750"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3583"/>
    <dbReference type="HOGENOM" id="CLU_034528_2_0_2"/>
    <dbReference type="OMA" id="KGPKNDG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="4">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="507" mass="54108" checksum="EBAFFE564F0A8732" modified="2012-11-28" version="1">MLLASFVVPIAMPAKAHAQSAITLNGAGATFPFPLIDTWRVEYNKLNPNVQLNYQSIGSGGGIKQFTEKTVDFGATDAPLTQAQFDAAPGAIHIPETIGSVVPTYNIPGIGNGELKLTGTVLADIFLGKITKWDDPAIKNLNQDLALPSEDIIVVHRSDGSGTTYVWTDYLSKASPEWEAQIGKGTSVPWPVGLGGPGNEGVANLVRQTTNAIGYNELAYAITTGMSHAQVQNREGNFIHASLETVRNAVAAESISLPAGDAPWHTVTMTNARGADSYPIASFSYLLVYKELSTFPSINSMARAKALVDFIHWAITDGQEFAPPLEYVPLPDEVVNHNLETLQMLTYNGEPVFEAPGQQAPATEPFTISYTLGGNTYTITGVSEEAKATSFRINPEQSIEVQLQGQGEIELTLPKSMVDGISTIRAGDQEIPYQQVSSSSSETTIRFTVPEGTDSVDIQAAMVVPEFEVIALLILAASIVAAIVIARVVMPGQSRSNNELAAFGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ0</accession>
    <name>K0ILQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stomatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02660"/>
    <dbReference type="EnsemblBacteria" id="AFU57214">
        <property type="protein sequence ID" value="AFU57214"/>
        <property type="gene ID" value="Ngar_c02660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02660"/>
    <dbReference type="HOGENOM" id="CLU_2103581_0_0_2"/>
    <dbReference type="OMA" id="DSATETW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-266-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="12671" checksum="0EFF676F6833E480" modified="2012-11-28" version="1">MIIPQELEAAMQMQAQAEREKNASVTYGESEVLVAKQFEEAAKVYENNHVAYVLRQSNMLYESMKVQGNTIVMIPSETLNSMGFGNLRMTLAYLKNTKKAATKPHAAAAAADTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR5</accession>
    <name>K0ILR5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59622">
        <property type="protein sequence ID" value="AFU59622"/>
        <property type="gene ID" value="Ngar_c27010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27010"/>
    <dbReference type="HOGENOM" id="CLU_2766238_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2701-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7785" checksum="84CF4A71D38CF8D2" modified="2012-11-28" version="1">MVDPVLHEGTGMHIMAKLGQSELATQPYSMLDESTKMNIVRLNRGELVIVHLAFRHPVKIVFPKVQFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR6</accession>
    <name>K0ILR6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cofH2</name>
        <name evidence="6" type="synonym">mqnC</name>
        <name evidence="8" type="ordered locus">Ngar_c27060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27060"/>
    <dbReference type="EnsemblBacteria" id="AFU59627">
        <property type="protein sequence ID" value="AFU59627"/>
        <property type="gene ID" value="Ngar_c27060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2683"/>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_2"/>
    <dbReference type="OMA" id="AFIAWNF"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="61"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="374" mass="41876" checksum="2C1E81AB212D8BC1" modified="2012-11-28" version="1">MQNRLLSDFLKKSDISDILDSALQGRRLGLNDCIRLIKSDDVYSMGLVANTLRQRLYGDTITFINNIILNYTNVCITFCKFCAFYRPPGHEESYTVPVEDIVKRVATSREMFGITQVLIQGGHNPNLKLEYYEDAFRAIKQKCPEVGINGLSPSEVDMIARVERSSTKEVLARLKAAGMDTFAGGGAEILEDRVKQEISPLKIKSHEWLRIMEEAHQLGFKSVATMMYGTVDTEEDRARHIMKIAQLQEKTGGFLVFIPWSFEPNRTEIQAEGKIKYPAGGLLLLKMIAIARIMYYGLIPHLQSSWLTNGIGMAQLALNHGADDFGGTLIGEEVVSATGARSTELTSDRIIAAIKQAGFRVAERDNSYKIIKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX1</accession>
    <name>K0ILX1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57414">
        <property type="protein sequence ID" value="AFU57414"/>
        <property type="gene ID" value="Ngar_c04700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04700"/>
    <dbReference type="HOGENOM" id="CLU_1237948_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-468-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="25921" checksum="449D942BEC2BAF24" modified="2012-11-28" version="1">MFFAFPHTRARFQYAHIRFFEREFGLEYTKFENRRMQEVYQAKTHKLSEVSGYVVWLRRNKAFLIVPTLTSPEPSVFCEIPDWINLEIPPDRAFVVTKGKWGYKVARGVEPSASPIFTVDHYKVTRPDLGSIRPDSTYHDFREILFEGLADVYPEVQDLVAHSIISSPKTLDRLGGLTLSVYNESKATSRVLLAYLKRFLPKEFLRQQALPSFSRADRSQHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX7</accession>
    <name>K0ILX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57424">
        <property type="protein sequence ID" value="AFU57424"/>
        <property type="gene ID" value="Ngar_c04800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04800"/>
    <dbReference type="HOGENOM" id="CLU_1173398_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-478-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="236" mass="25591" checksum="26074E00448A050E" modified="2012-11-28" version="1">MKTKLAIAAIAALLALFGGIFALATPALANLYSDTMTSSSDMATDDGDNDDSNTMTSRLMDHSIMSWFDKGKKFGIVSSIQNEDGEPAWVVVGHWMMTNETGNIDFYAGFYMTRLDGSAQHTHEIYNFRQAGESSTEGNVTMVRGTSTVTLREGPAEDVETTITLSQGNVIAISLDREAVEDHFGDTPIYGMTITPEIIHHIMNATTASKMMGNYGGGMHSGSNNDDTTMTGEMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILY1</accession>
    <name>K0ILY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59787">
        <property type="protein sequence ID" value="AFU59787"/>
        <property type="gene ID" value="Ngar_c28680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28680"/>
    <dbReference type="HOGENOM" id="CLU_2230468_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2868-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11548" checksum="0D3C702B3DA16A88" modified="2012-11-28" version="1">MILIAIPLPASLICWPALFQLNNFTIYTATSAEECLALYSDLKDNVDMILMDDAIAGNSRVEVIINIMRIKLDQRIMVVVEKDIVKAVAMRVGAGVVVMKPISPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ4</accession>
    <name>K0ILZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59822">
        <property type="protein sequence ID" value="AFU59822"/>
        <property type="gene ID" value="Ngar_c29030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29030"/>
    <dbReference type="HOGENOM" id="CLU_123710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2903-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="20263" checksum="CD458DA3710471F7" modified="2012-11-28" version="1">MSQRVKPSRRNFRCMLSVGLAAATLALVLTYVLGAQVLLQTPYAEPAHNLFMSLVQGIVGGHSSMAQLHGGSAPDSQSQAMPESESQMQEMNRGILGNNMLGSPAGMAAAGLAAVTLIGIIPLAAAAFVISWKQRSFVVAGLLAASGIILMILPLANMNFAIPGPIIGVVVGLAILGLGVAKGITSARTAVATTTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC9</accession>
    <name>K0IMC9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08520"/>
    <dbReference type="EnsemblBacteria" id="AFU57794">
        <property type="protein sequence ID" value="AFU57794"/>
        <property type="gene ID" value="Ngar_c08520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08520"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-850-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="15736" checksum="A5BCF0A10BFC73C0" modified="2012-11-28" version="1">MATKGEKYKILVVDDEPDITSVIKKGLEKEGFEVQAFNNPTEALSHFKVGAFDLVLLDIRMQPMNGFALFKQLRKIDDKVKVCFITAFEIYYDEFRKVFPKLRVNCFVRKPVRIEELANTIRDELELTDEIKLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG3</accession>
    <name>K0IMG3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60252">
        <property type="protein sequence ID" value="AFU60252"/>
        <property type="gene ID" value="Ngar_c33370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33370"/>
    <dbReference type="HOGENOM" id="CLU_2730548_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3337-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8128" checksum="196B59380694F867" modified="2012-11-28" version="1">MDRAFANKTMTAENLKLMLDKSAHLYGQLRFVHLSAHLDTMQVLTAEQVHIYNIWKDMMITTTNNTQCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG8</accession>
    <name>K0IMG8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60267">
        <property type="protein sequence ID" value="AFU60267"/>
        <property type="gene ID" value="Ngar_c33520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33520"/>
    <dbReference type="HOGENOM" id="CLU_2366308_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3352-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10471" checksum="DEC1EDCDDD3A22FA" modified="2012-11-28" version="1">MLQRKSLLFMIAIAPGAAILAIASYNFTTEKIIEISEQDIHSNAQIEAHAISNALTSRIADVDHNLALLASAPLVQRGTRERSSCLMPRRTILWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI2</accession>
    <name>K0IMI2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33920"/>
    <dbReference type="EnsemblBacteria" id="AFU60307">
        <property type="protein sequence ID" value="AFU60307"/>
        <property type="gene ID" value="Ngar_c33920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33920"/>
    <dbReference type="HOGENOM" id="CLU_050976_0_0_2"/>
    <dbReference type="OMA" id="INVITHY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3393-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="38724" checksum="9D65D28CF669CDB4" modified="2012-11-28" version="1">MERIEITLYPNQAEEIEKILEEFQVPYIKTSAESYKIQCLHYVIISPNEIAGALVDIIAHKFDTNQRINVITHYKPEATISDYLRKFEAFLKEEVTPASITSTDIDIVSGFKSVKDKIPIKRTGPIEGLVSRTDAFLSRKMDVYSMILVATVIALVGLVSNNVAVIIGAMLISPLMGPIASIALNSVLGRQKQIEKSIVFGSQMILSSIGLAAALTAALALFYPVETTPEILSRTEVSPILIVVAVMLGIAGGLAMLTSIPEIIVGVAIAVALVPPATTIGIGIGLGSIDIAASASLVLLSNIIGMVIGFMIIFLLKGVSPRKYYEKKKAREVLRLNVMVLVALAVALGAIEVLFGYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ4</accession>
    <name>K0IMQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="6">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoK</name>
        <name evidence="6" type="ordered locus">Ngar_c11580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11580"/>
    <dbReference type="EnsemblBacteria" id="AFU58099">
        <property type="protein sequence ID" value="AFU58099"/>
        <property type="gene ID" value="Ngar_c11580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1098"/>
    <dbReference type="HOGENOM" id="CLU_144724_1_1_2"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12222" checksum="840C557961DA7D7A" modified="2012-11-28" version="1">MHLRAERTWSNNMSELIDFLIVALALVAIGIYGLVVKRNAIRMLFSIEIIANAANLVLVAFARGLPNAQGQTFALFSIAIAAAEVAVGLGLIIVAYRLYKEIDVAEFRSMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX0</accession>
    <name>K0IMX0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58359">
        <property type="protein sequence ID" value="AFU58359"/>
        <property type="gene ID" value="Ngar_c14230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14230"/>
    <dbReference type="HOGENOM" id="CLU_1318573_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1421-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23180" checksum="ED4BDCFEF103DC8C" modified="2012-11-28" version="1">MVHFRNDKILISSVAGAGAAATTIVLFLLPLLSSGDTGITYRGYVSENNIYNNSLYKLSIAYPPGWKVLEDVGIKNSEIGSAFGTDRLSFVVVFAGPVQDNFATNINIETNYMQGMSLEEFAQNTEKSLASTFSKNNFTVLDKGHTEINGRDAYFITATLEMEQPIKNELVILERDNYAYIITYNAMATTFDDHIQEFEDSLSTFEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX9</accession>
    <name>K0IMX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c14680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14680"/>
    <dbReference type="EnsemblBacteria" id="AFU58404">
        <property type="protein sequence ID" value="AFU58404"/>
        <property type="gene ID" value="Ngar_c14680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14680"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1432"/>
    <dbReference type="HOGENOM" id="CLU_023791_0_0_2"/>
    <dbReference type="OMA" id="RCDIHYA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1466-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="104"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="567" mass="64896" checksum="E8C5D5090E496C2C" modified="2012-11-28" version="1">MDLIQISNMSSKSVGARRTIRFTQSICPDCNMILDAEVFERGGKVFMTKTCPTHGECEELYFGSYEMYKKFSTYWMDGKGAHAPNVMIDKCSCPNNCGLCTNHLSHSGLSNMIITNRCDLTCWYCFFYVKKGLEGAYLYEPNMEQVRAMMKTLKAEKPIAGNSIQITGGEPMLRDDITEIIKIMKEEGVDHVQLNTNGIKLAMSPETMRQVRMAGVNNLYLSFDGVTPRTNPKNHWEIPYTLESARKCGMTVVFVPTVIKSINDHELGSIIRYAQKNLDVVHAVNFQPVSLTGRMGKKEREKYRITIPDCIERIEEQTNGEISKDAWFPVPSCMPMTNIIEAFSKKPKYELSIHFACGAGTYVFEDMDTKKLIPLTSFVDIKGVLEYFEEKADEIKSGANRYWAMLEVVRKLKQFVNKDKQPRGLDLAKMFSSILLKRNFDSVGSWHVRSLFLGMMHFQDKYNEDLERLQRCDIHYLTPDLRIIPFCAFNVIPEWYRDRIQKKYSIPVEEWEKAHGQTLEAGLYRGLMRRGKPEAQMGCAMSEIHRAAAEASDDHRGIELRNNMAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN18</accession>
    <name>K0IN18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58599">
        <property type="protein sequence ID" value="AFU58599"/>
        <property type="gene ID" value="Ngar_c16660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16660"/>
    <dbReference type="HOGENOM" id="CLU_2433961_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1664-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10336" checksum="300D3439B827FD6F" modified="2012-11-28" version="1">MQTKKNSQVPDIDEDRDLELENIIGNLMIAQYQVDKLRSRLSERVGGYGSASNKKGSAHIFKHNDKWYKVTVRVDEMVISQRDIAADEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN40</accession>
    <name>K0IN40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family UPF0201</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17760"/>
    <dbReference type="EnsemblBacteria" id="AFU58709">
        <property type="protein sequence ID" value="AFU58709"/>
        <property type="gene ID" value="Ngar_c17760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17760"/>
    <dbReference type="HOGENOM" id="CLU_131306_1_1_2"/>
    <dbReference type="OMA" id="NMAGAYA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1774-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16710" checksum="BEB1F06704F36425" modified="2012-11-28" version="1">MPEEDLKFSTAEVNLVLHATEDGNKVLQSIHDVLSVPLERFSVSPSEGHYKNKILLLKAILSSQEAGELARRIMSLLNSSDREHLSSSLPEYSDEKGNLYLRLDKQRIVQGKVSLSEADAIRIRFRPVKRYRPSGNLESYRGLLSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA5</accession>
    <name>K0INA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxylate reductase</fullName>
            <ecNumber evidence="4">1.1.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gyaR</name>
        <name evidence="4" type="ordered locus">Ngar_c21030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21030"/>
    <dbReference type="EnsemblBacteria" id="AFU59034">
        <property type="protein sequence ID" value="AFU59034"/>
        <property type="gene ID" value="Ngar_c21030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2083"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_2"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="6"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="110"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="36354" checksum="510124F05F09B375" modified="2012-11-28" version="1">MSNKVYVTRKILDPALPMLSKECQVTLNKKPNPPSRAEVLKNVAGKDGILCMLSDRIDSQVMDAAGPSLKVVSSYSTGFEHIDIREATARGIYVTYTANILAEATADLTFALILACARNIVKADRYVRENKWKVGWSPDLMLGYNVHGATLGIIGLGRIGAAVARRAKGFNMKILYHNRSRNQQLGSELGARYVDLDDLLAQSDFVSIHTSLNSTSRHLIDSSKLSLMKKTAFLVNTARGQVVKEADLVRALKGSRIAGAALDVFENEPLSRTSPLLKMKNVVLLPHIGSATYQTRSKMAEVAARNLLDVLAGKEPDPRFLVNPEVKSVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA6</accession>
    <name>K0INA6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V4R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21080"/>
    <dbReference type="EnsemblBacteria" id="AFU59039">
        <property type="protein sequence ID" value="AFU59039"/>
        <property type="gene ID" value="Ngar_c21080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21080"/>
    <dbReference type="HOGENOM" id="CLU_105305_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2106-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="229" mass="25450" checksum="228E0C7EC6093DCD" modified="2012-11-28" version="1">MVVGGMSHASRHLASSLLIIKLKVGKSYIKEFYTQNSLMAESSNVPRKEASEHDSTVYLNPYFHFDPKANITEDLVFKCKAILTNEQFWNAIQDGLDVLLKEAGAVILFQMGLRYGVEVGSKAKEAIPDVHQAVKFLETYGLFSGWGKFTTSPFSLSMGHLTDSVTVKVENSFFATMGKKKWETPRCFLISGLLAGITEGLLGEGHNCIETKCMATGSKYCEFLITRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC3</accession>
    <name>K0INC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59124">
        <property type="protein sequence ID" value="AFU59124"/>
        <property type="gene ID" value="Ngar_c21940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21940"/>
    <dbReference type="HOGENOM" id="CLU_145187_0_0_2"/>
    <dbReference type="OMA" id="AIYRFEL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2192-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="16747" checksum="6127D84F58D03E1B" modified="2012-11-28" version="1">MGRTKAAKSEGGSQEEGLPKWAEDEIKSAQFGKPETITRTGYILDIYESDFKVDIQVYEPMPDGRTIVEGLDVPKSMKISDFMKGFVYEFKVKVFTAPLSAKVVELLKTKFDLDMKAIYRFELQELQLMDVESDLPAAASSSEDGDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING4</accession>
    <name>K0ING4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative multicopper oxidase type 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c24040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24040"/>
    <dbReference type="EnsemblBacteria" id="AFU59329">
        <property type="protein sequence ID" value="AFU59329"/>
        <property type="gene ID" value="Ngar_c24040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24040"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2377"/>
    <dbReference type="HOGENOM" id="CLU_031740_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2402-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="229"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="359" mass="40460" checksum="643ADDAE2C869777" modified="2012-11-28" version="1">MPEKSLLSVLFIAGMLGASLAALPLMQAHVSASKMTDNNISIEEYDKMKNCTTDLDKRPTSIEYLTHFNCGRVSTTEDGQTIREFTLIVEENQTVPVSHEGHTLNAWTFNGTVPGPTMRMTEGDLVRITVINSEDSVHPHSLHMHSIHEAAMDGVQSDPIAPGDSFTYEFIAQPYGVYPYHCHIDPIADHINRGLYGILIIDPKEPRPQMTELAMMMNSYDLDYDLEGPVTIPTVQELESGNRTEEEERGNEIYTVNGKAFDYMHYPIELEVGKDYRIYVVNMVEFDLVNSFHVHGALFEYYPSGTSDKPAFTNDIIVLGQGDRGIMEMSYKYPGKYMFHAHVSEFTDLGWMGFFNVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX6</accession>
    <name>K0INX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60139">
        <property type="protein sequence ID" value="AFU60139"/>
        <property type="gene ID" value="Ngar_c32230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32230"/>
    <dbReference type="HOGENOM" id="CLU_2103587_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3223-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="12471" checksum="0651B6B6557D12EA" modified="2012-11-28" version="1">MKIVDGKRMGSVTVFEDTIMLAEVVGDVILNSGHLELKGKVLGNLFVRKGTCRMLGIIRGNLENEKGDVEVFGTVHGKVITKSGYTYVNPGSKVGSIEHAVPVKREEKEKEAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6Z0</accession>
    <name>K0I6Z0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UPF0330 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57031">
        <property type="protein sequence ID" value="AFU57031"/>
        <property type="gene ID" value="Ngar_c00810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00810"/>
    <dbReference type="HOGENOM" id="CLU_170073_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-81-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8208" checksum="47625D0A66257704" modified="2012-11-28" version="1">MLSDEAYNALKAAKKEGESFSDVILRKFPKGDPARILAVVKSMKPNPDLSQSVRQASKEMRRDFKMREFDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7B2</accession>
    <name>K0I7B2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secY</name>
        <name evidence="14" type="ordered locus">Ngar_c02020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02020"/>
    <dbReference type="EnsemblBacteria" id="AFU57151">
        <property type="protein sequence ID" value="AFU57151"/>
        <property type="gene ID" value="Ngar_c02020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02020"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.202"/>
    <dbReference type="HOGENOM" id="CLU_031763_3_0_2"/>
    <dbReference type="OMA" id="KWGIGSG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="13">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="485" mass="52124" checksum="1AA1A78E25CEC321" modified="2012-11-28" version="1">MSSTTTSEHGLRRFIKAASAYVPQVPKPKKKVSLTEKFVWTGIALFAYLVMAQIPLYGVTDDPRFDFLAFARVIFAAQQGTLMELGIGPIVTAGLLMQLLKGSDLIRLDFKNPDDRSLFTSATKIVTIIVIVAEGALYGASVYGPLTAPEAPHAIYVLVLQLIGASVIVMLMDEMVQKGWGIGSGLSLFIMAGIAQTILWSVFSVVPADDGPVGIFPFTIDAIVNGHGADAIFRVGQLPSLFVLALTIAIILILVYIEGIHVDVPIVSTKYRGFTAVYPIKLLYTSVIPVILASALIANAVFMGNMLWANYNPNNQNPAFNWIAMFDTQSAQQGGQPTPIGGILYYITAPRGLDAAAADPLRAVVYVLFLTGIVTVFSRLWVELGGLSARTAARNLLDADVQVPGFRRSEGSVETLLNRYIPALTLLSGIIIGLLAGISDVLNVFGTGTGILLMVNIMVSYYQTLVKEQVDVNMPGLAALIGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7D1</accession>
    <name>K0I7D1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57166">
        <property type="protein sequence ID" value="AFU57166"/>
        <property type="gene ID" value="Ngar_c02180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02180"/>
    <dbReference type="HOGENOM" id="CLU_2857203_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-218-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7040" checksum="822240C87B5775E3" modified="2012-11-28" version="1">MQNMMQKGIGSFLSSGGNDKGSMQSALSQLDGGLNNIEHPLVQQVKQNANLRDDNQQNNTHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8C4</accession>
    <name>K0I8C4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c05830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57526">
        <property type="protein sequence ID" value="AFU57526"/>
        <property type="gene ID" value="Ngar_c05830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05830"/>
    <dbReference type="HOGENOM" id="CLU_1891500_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-581-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15066" checksum="CFBBA7896620983F" modified="2012-11-28" version="1">MVKNRHLACHVLDSGWRLFKGLLNYKSKIVIEVEPAHTSIDCSKCSNKIPKSLAVRIHRCDRCDIVIDGDYNASLNILRKGLLLLLPQRLREVTPVEIPKESLKQEEAIEQIASSPKSDSFALALGLRRSAYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I981</accession>
    <name>K0I981_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57886">
        <property type="protein sequence ID" value="AFU57886"/>
        <property type="gene ID" value="Ngar_c09440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09440"/>
    <dbReference type="HOGENOM" id="CLU_1656926_0_0_2"/>
    <dbReference type="OMA" id="KNFRYLA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-942-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="159" mass="18233" checksum="86A1D1853777C3B6" modified="2012-11-28" version="1">MKRGYLKIHVAVDIRKKKVVSLEVTSEEVHDGKVMKKLVKGASENNGIKRVLADGAYDSKKNFRYLARKGIEAAIKVRKNSSGKAMGCYPRKLVVLQQLSDFDKWKSSVSYGQRWMAESVFSAIKRMFGEYVMARNYQNMVKEMFLKVSLYNMFAGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9D9</accession>
    <name>K0I9D9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagella protein FlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flaI</name>
        <name evidence="2" type="ordered locus">Ngar_c10140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10140"/>
    <dbReference type="EnsemblBacteria" id="AFU57956">
        <property type="protein sequence ID" value="AFU57956"/>
        <property type="gene ID" value="Ngar_c10140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.965"/>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="CLEYGMS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="187"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="564" mass="63275" checksum="77C77289CBD9B2B3" modified="2012-11-28" version="1">MQSTKQAADQNQPQSQMDPKLMEQMQKVPYLMEYVSAFIQKGNPSPAFYEKIDGSFKSLKMPNLIYPISENNLIHINAYASGGDGYFEYVVIGPPEPDARLLGAVDRMFATYAGSWKPPDQLQERFMAVGNFLDKICVKSPTPVQYDKIDAKKTKTIPVYEKEYEYLKYHFLTKRVGLGILDPFLTDPHLEDISIVGAGNVYVVHKIFGPLRCTVWLTMDDIDDMVIGMSEQFGKTISHARPLVDATLPEGSRINIVFGKDVSRRGTNATIRRFASVPLSITQIINSKSIDAREAAYMWMMVGEGMSCFINGETASGKTTTMMGITQFIPPTWKIVSIEDTPEITLPHKNWISEVTRDTGSPSSSVVMFDLLKAALRQRPNYILVGEIRGAEANIAFQAMQTGHPVMSTFHAAQMSSLIQRLTGEPMKIPKPNVENLNIALFQAAVQGKDGKPVRRVLSINEIVGYNGGADSVMFVPVFTWDPASDTVTYRGKGSSNLFITKILLKRGLSRKDEGSLYDELELRTKILETMIKKKIFNYYDVYDRIVQAKEIGLEKFKKELDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9Q8</accession>
    <name>K0I9Q8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gmad1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58056">
        <property type="protein sequence ID" value="AFU58056"/>
        <property type="gene ID" value="Ngar_c11140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11140"/>
    <dbReference type="HOGENOM" id="CLU_724848_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1112-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Gmad1" evidence="2">
        <location>
            <begin position="221"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="381" mass="42266" checksum="E04D5325015BC23A" modified="2012-11-28" version="1">MMPVIAKIGLAITSFLMLFLSLFLTAAFDSHAFTQTQEAPMNYFKAEGVVTEIDVSEMQSEIVSPTGNDDDHNRTYFELHDWDSQSGKVLFTSGQFIGIMNANATDIQKIILPSELHDELCWECSPVRKALFINNTTIYALAQNNLLIYEITNDALVNAGQYQLAGSITSFDIIRQTNGDSSNNSSDTNFNLVLVDSYCTLWLSDPLGKKISKLYEAQMASDFAVSPDGRKIAFVVNDSIEGHVYLHTVRLIILDIENSSNNKTHQVYEEMTDTTPNWIKWSPDGKLILFREVGGRHNPTATLEAISTDGSYREILYGGLDAPTSYVVSKDGTTILIGVSASKLYRLDLAHPIPEFHSLALVIAALSISSIILAHTYMKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9Z9</accession>
    <name>K0I9Z9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58151">
        <property type="protein sequence ID" value="AFU58151"/>
        <property type="gene ID" value="Ngar_c12110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12110"/>
    <dbReference type="HOGENOM" id="CLU_113181_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1209-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="191" mass="22246" checksum="00CA96D68944E5D7" modified="2012-11-28" version="1">MGYPFLILMASRKEERKDEAAARQAEAQEVVSRTLDEARDSTKRALEEARRDISARTASFNEYQEQTINAARDIADNYLESQKEIVNSMQSSWVPFIENMYGMYWTGWMSPRRMTEVYARMARNFSDNAISATRMANNMVFANMEAAKASIQYTRDNMRELSRMSINAVKTFEDTSKSYQESMRTEEKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAK9</accession>
    <name>K0IAK9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58356">
        <property type="protein sequence ID" value="AFU58356"/>
        <property type="gene ID" value="Ngar_c14200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14200"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1387"/>
    <dbReference type="HOGENOM" id="CLU_2505062_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1418-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="7375" checksum="56B2A45E4622416D" modified="2012-11-28" version="1">MLATVVATTLVPAAAVAQVTGGNGGTATGGNGGNGGNGGAGVGIGGLFGIGIGGNGGNGGNGGNANARGGDATCNSFVALLSGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAN9</accession>
    <name>K0IAN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58396">
        <property type="protein sequence ID" value="AFU58396"/>
        <property type="gene ID" value="Ngar_c14600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14600"/>
    <dbReference type="HOGENOM" id="CLU_2379504_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1458-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10408" checksum="151542705CE4D533" modified="2012-11-28" version="1">MESVLAESTRLIEYPADLSGCSIIGVGDRQLLYLCTRGSGKPLVVVLGFFSGQKEDIITKDLIEPVVEESRRRIGEIVASSLFDEYQNAQILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBK8</accession>
    <name>K0IBK8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17280"/>
    <dbReference type="EnsemblBacteria" id="AFU58661">
        <property type="protein sequence ID" value="AFU58661"/>
        <property type="gene ID" value="Ngar_c17280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17280"/>
    <dbReference type="HOGENOM" id="CLU_017233_1_0_2"/>
    <dbReference type="OMA" id="FPIHKDL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1726-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="280" mass="31565" checksum="454AA62D19DB4946" modified="2012-11-28" version="1">MPNLWVAIPDSSLSDEQTRRDKSIKIAQFARACAIFQVKRIYIYHDSLSQFERDDPNLLKTILRYLDTPQYLRKALYPRMHQLEYAGILHPIKAPHHKPPEDIKRVRAGDVRTGVITKVKGQLFVEAGLGSLVPFVGQGFEGKKVNVKFISPYPNLKAIEASEEDIFEYWGYEVKEVPSLGKLLLASAENTEVVITSRKGSYFKNVEAKLIERAKNAQNILVVFGAPKHGVYDILAKEGASIKPYEFVVNMFPNQGTETVRLEEAVLGTLAILNHSIGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBU9</accession>
    <name>K0IBU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58756">
        <property type="protein sequence ID" value="AFU58756"/>
        <property type="gene ID" value="Ngar_c18230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18230"/>
    <dbReference type="HOGENOM" id="CLU_2839485_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1821-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7467" checksum="BFD22B29A701568D" modified="2012-11-28" version="1">MGMILLEIATERMVIDKDDECCIQLLAEAVNNRAKIRKAYNSFVTSTLTCLPWIFTIFQLSLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBY0</accession>
    <name>K0IBY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58811">
        <property type="protein sequence ID" value="AFU58811"/>
        <property type="gene ID" value="Ngar_c18790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18790"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1863"/>
    <dbReference type="HOGENOM" id="CLU_1052176_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1877-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="264" mass="28784" checksum="23DAA3D2F392C27F" modified="2012-11-28" version="1">MVATFLIGMLLSIARLDSAYATTSAPTPSGGSETAILVIGDQEFDIQYTINGGTLEERMTADPALKTLLVTISSTSDGNLTIGLPTEAIDAEDNEFSVFVDGEFRNFVVDELKRTADARVLYIEFENGTEEIEIVGTSMAREEDEEPEPAPQTFSVEIEDRSYDIPYKVTGGFVQSVSADIESKSLTVSISSNTSGILALWLPTEMIDADDEFSVLIDGQAANFTELDSTDDARVLQVEFENGSEEIEIAGTFIVPELAVWQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICJ6</accession>
    <name>K0ICJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csa1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csa1</name>
        <name evidence="1" type="ordered locus">Ngar_c03770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03770"/>
    <dbReference type="EnsemblBacteria" id="AFU57325">
        <property type="protein sequence ID" value="AFU57325"/>
        <property type="gene ID" value="Ngar_c03770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03770"/>
    <dbReference type="HOGENOM" id="CLU_905009_0_0_2"/>
    <dbReference type="OMA" id="FAYGYCP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009260">
        <property type="entry name" value="CRISPR-ass_Csa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06023">
        <property type="entry name" value="Csa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01896">
        <property type="entry name" value="cas_AF1879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="326" mass="37017" checksum="AD424076B0567BF7" modified="2012-11-28" version="1">MYFLSGEDRRRLFKGIVSRGRTMTVDESLRGWNWDKPPIEPPYDTIKLGVYEVASQYCQSGRDVFVRRIDGIKGVPSKDMVRGLVYHYAVADEISVAKAYMYKQGVLGAAGLYEHLKAKSEERFASYMLTHGEYFREAAFTEADIEEVKMNLDKLWGYEASQMAASIKAILSKQPRIGIDALVHTAIPVIVEQKIDGSALGLSTHLSVDAFSFDSIILDLKTGEEKEFHKLSTTGYALVYESIFEYPINVGCVVYVNFSNNSPVPIIKRVPHLIDETLRREFLEARDLRMKMIYDRRDPGLPRKCYAKCQYLRHCGVGPEQIEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICQ7</accession>
    <name>K0ICQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57425">
        <property type="protein sequence ID" value="AFU57425"/>
        <property type="gene ID" value="Ngar_c04810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04810"/>
    <dbReference type="HOGENOM" id="CLU_2103582_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-479-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="12313" checksum="19BCA22DC96DAA2B" modified="2012-11-28" version="1">MLSLGVLDTVASRLDRGTIATILAIVFFGAGHIYLGQVRRGIAILTIGIGLLLIAYPGFIGVQYMSSSGIDMQTITRSTIVNISLFAVGLGSIGYWVWQIIDARKLATKQQIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID51</accession>
    <name>K0ID51_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein Ngar_c06470</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06470"/>
    <dbReference type="EnsemblBacteria" id="AFU57590">
        <property type="protein sequence ID" value="AFU57590"/>
        <property type="gene ID" value="Ngar_c06470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06470"/>
    <dbReference type="HOGENOM" id="CLU_134829_1_0_2"/>
    <dbReference type="OMA" id="YIHRHRE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-645-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="14893" checksum="56625840CE4A918A" modified="2012-11-28" version="1">MKRLAIGSPVELKVEAPVNPSEDPQKVIDAIETIIESCSPEFRYGSRVIGRAAGIEPLSVLYEQVRSRSTMGVLRRMLLDNRAGDSTWFLLNKQAATAGIAVIIDEEQESPLGPIRVTISCEELDTLIDWLVPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID84</accession>
    <name>K0ID84_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59351">
        <property type="protein sequence ID" value="AFU59351"/>
        <property type="gene ID" value="Ngar_c24270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24270"/>
    <dbReference type="HOGENOM" id="CLU_2103386_0_0_2"/>
    <dbReference type="OMA" id="AFGWHFF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2425-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13248" checksum="9FE67778B3936CC7" modified="2012-11-28" version="1">MEFDPELIVMQAASTEPDTKAIEDLMGEVLMMAHAEESAIHISSAEQTFGWNFYIMSVDKEVARQLAQLPESGLLAVRGDSLEQKFVGWLNRRAKAKGADGKVHFNLLSDLNSSRYGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDG6</accession>
    <name>K0IDG6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ammonia monooxygenase subunit B</fullName>
            <ecNumber evidence="1">1.14.13.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">amoB</name>
        <name evidence="1" type="ordered locus">Ngar_c25230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.25" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25230"/>
    <dbReference type="EnsemblBacteria" id="AFU59446">
        <property type="protein sequence ID" value="AFU59446"/>
        <property type="gene ID" value="Ngar_c25230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25230"/>
    <dbReference type="HOGENOM" id="CLU_1431582_0_0_2"/>
    <dbReference type="OMA" id="ATRPWQV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106317">
        <property type="term" value="F:methane monooxygenase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106318">
        <property type="term" value="F:methane monooxygenase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006833">
        <property type="entry name" value="NH3_CH4_mOase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023301">
        <property type="entry name" value="NH3_CH4_mOase_suB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04744">
        <property type="entry name" value="Monooxygenase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="23199" checksum="AB864C8B27844AA0" modified="2012-11-28" version="1">MPKFGARAARAKYISLFFLVYLRYRDMMESKTLVVTALATVMVLSAFAVVFQSADAHGVQAQLQSRFVRIDNEQFSDQTLNTGEQLTVTGELRSLVNRPLRAWLSLFSESANAGNRWEFLQRDPPGNIFDIPAGGTVPYSITVKALEPGTYHVHTQLNVEHVGPGLGRGATVNVSGEAILKPIPYSNIVYQCVIIGVGLGVTFATRPWQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDT7</accession>
    <name>K0IDT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57895">
        <property type="protein sequence ID" value="AFU57895"/>
        <property type="gene ID" value="Ngar_c09530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09530"/>
    <dbReference type="HOGENOM" id="CLU_2893367_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-951-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="6703" checksum="6B03BBD6DA7ECF3C" modified="2012-11-28" version="1">MAATNWSLAYVASLGGWENTEILNKCYGGIPEHIKAQMAKSVHVRFDTLSLNISIAATGYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDY4</accession>
    <name>K0IDY4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57033">
        <property type="protein sequence ID" value="AFU57033"/>
        <property type="gene ID" value="Ngar_c00830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00830"/>
    <dbReference type="HOGENOM" id="CLU_191925_0_0_2"/>
    <dbReference type="OMA" id="HPKESYN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-83-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="9008" checksum="71F009C37E5C08CC" modified="2012-11-28" version="1">MDTTIQIDKKTRDKLKELKIHPKESYNNVVERLLALRIDEEELSEETIRDIEQSLEDVKAGRTLSMQEVKQRLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE00</accession>
    <name>K0IE00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC uptake transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c10430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10430"/>
    <dbReference type="EnsemblBacteria" id="AFU57985">
        <property type="protein sequence ID" value="AFU57985"/>
        <property type="gene ID" value="Ngar_c10430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10430"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_2"/>
    <dbReference type="OMA" id="LWQQGWL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1041-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="30766" checksum="1DF170A3ABA3FB55" modified="2012-11-28" version="1">MSYRRISDLQKLILEARKQKHRIDTTYIANTFLFLAAFVGIWQLVSNIGIFPSVLMPTPAKVVGTIARLVTDSSLVVGIGVTMWRLIAGFAMAVGIGGIVGLAMVKFLGFGKTMSSFAVGLLTFPSIAWVPFSILLIGFNDFGILFVVIMASVFSVMTSTYSSIRNVPPIYIRAAKNMGAKGFTLFRYVMIPAATPSLIMGIRQAWSFAWHALIGAEILITTLYGLGHVLHVGREFNDMSQIIAVMIAIFAIGLLVDRLVFMRLEEKVRARWGLNQHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE29</accession>
    <name>K0IE29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58025">
        <property type="protein sequence ID" value="AFU58025"/>
        <property type="gene ID" value="Ngar_c10830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10830"/>
    <dbReference type="HOGENOM" id="CLU_2021575_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1081-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13519" checksum="4F2F34CFB3B56F4D" modified="2012-11-28" version="1">MRAEKDIRLRIDLLEGQSSSIAKMLAKAIRDHNEAAFKEYSERLAANRSRVEELLWVLGEKAGQSVLDLQVAAASNNSSLSVKEVIEKLKAGELKMDDLSPDAQAMVRKGALEMKNNNAHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE66</accession>
    <name>K0IE66_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59651">
        <property type="protein sequence ID" value="AFU59651"/>
        <property type="gene ID" value="Ngar_c27300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27300"/>
    <dbReference type="HOGENOM" id="CLU_1954733_0_0_2"/>
    <dbReference type="OMA" id="IATIICW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2730-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14462" checksum="07E26A797AD130A2" modified="2012-11-28" version="1">MQVYLMLLDSPDPIGAREVQRRPDYSSVNVAVHHLEKLCRVGLATKDEHGRYSASRKVSIGIMELFMNIGRVRFPRLLFYAAFFAALAVMYFATAPIVLGRDSVYVMVFAIAGTGLLAYEAFKVWRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEA8</accession>
    <name>K0IEA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58110">
        <property type="protein sequence ID" value="AFU58110"/>
        <property type="gene ID" value="Ngar_c11700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11700"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1107"/>
    <dbReference type="HOGENOM" id="CLU_025554_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1168-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="685" mass="74227" checksum="531E5B2894BCB8E8" modified="2012-11-28" version="1">MQNTTSLVTISGEQFVLADSKITRSFSYPLLEFNGEIAAELTVTLTWDTDGTTKVKDNRGYSYTISIPELQGAFSLWYNSTHVDQRVVGPELQYDVYWTAVEGGNGYVDRYKYTIAGTSINGSIISFVVDGGKYDKIDDDRLFVGQPASVDIDASTLDPALDWTPKGVRNDQTSATNEGRNDKEGGLELDWSDAIASGHNMVFDQSNSTLRIPVDKWFIIDPTVVATTAQTLSPPSNSAFEGERRLITTNNTNTDLTTVNAFYYDGSNIVYRTSTDMGHTWSASAVSTGSGVLAADTSRWSVITTTIDSTQYVSLLYWKPAGTNMEFYAKRGTVNSDGSISWSSPILLGYTWANSDVCGSGSACGGVTTAADVNGTIYAAFTWLSGGATDYSMQIMKSTDGGLNWSTSMNQMYPVSSSRPAMALATLNSTKMLFVYAKYESASLFYKVFDGSAWGSEQTQSSVGMTTNTFKQLSAMSNTTSAVYVAYTNVTSTAGGILKIAAFSEEGSFIASETADNTLRHYLPDILRGSNDDIIINSLADGKVYNTRKANGVWEPPFDPYGTTFDSPNQLTATNFHMGEPGALWIEGTSSPYNIVFGHMHHGVVGKSSAQTSPQLSDYYEGERRVFSSKGGTKYAFFYDGSNIVYTKSYDSGHTWKGTSTSTGSGVLASDSFRWTIATTMVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEG7</accession>
    <name>K0IEG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thsA4</name>
        <name evidence="6" type="ordered locus">Ngar_c28160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28160"/>
    <dbReference type="EnsemblBacteria" id="AFU59736">
        <property type="protein sequence ID" value="AFU59736"/>
        <property type="gene ID" value="Ngar_c28160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28160"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2781"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="KNYKNYG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="558" mass="59397" checksum="6683C5F4964ADAC7" modified="2012-11-28" version="1">MSIQQGSAGGVPVLILKEGASQTKGRDAQKNNITAAKLIAEIVRSSLGPRGMDKMLVDTLGDVTITNDGATILKEIDVQHPAAKMMVEISKATDNEVGDGTTSVVVLAGALIEKAEELINKDVHPTIIVDGYRKSATKAIEVLNSIAQKIEGNEKAELARIARTSMQTKLVSKEAGDLADIVVTAATSVAEKTDTGYRLDIDDIKVEKKAGGSIRDTRLIKGIVLDKEVVHGGMPKRIENAKIALINSALEIEKTEFDAKININSPDQMKMFLEEENRMLKSMVDKIIASGANVVVCQKGMDDIAQHYLAKANILAVRRVKESDMSKMSRATGARVVNNLDDLTAKDLGSAELVEERKVETDKWVFVEGCKHPKSVTILIRGGSQRVVDEAERSVHDALMVSKDVLEKPAIVAGGGAPEAYAASKLREWASTLSGREQLAAEKFAEALEVIPLSLAENAGMDPIDTLTELRSKQSKGSKWTGVDARNAKIADMSKLDVVEPLAVKEQIIKSATEAASMILRIDDVIASSKSGGGPPAPPGGGGMGGMGGMPGMGGMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEL3</accession>
    <name>K0IEL3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stomatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02650"/>
    <dbReference type="EnsemblBacteria" id="AFU57213">
        <property type="protein sequence ID" value="AFU57213"/>
        <property type="gene ID" value="Ngar_c02650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02650"/>
    <dbReference type="HOGENOM" id="CLU_2285131_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-265-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11527" checksum="6A5BF2704A8BFBB8" modified="2012-11-28" version="1">MDVREFKAEQMLTKDNVPVTIDAIPRYRIIEERVRNAVLNVENFNQMIQQVSQTTLRNNIGSSVFQDILSRREEVNQHIKSVIAGEAGNWGSKLLASRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IES3</accession>
    <name>K0IES3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29380"/>
    <dbReference type="EnsemblBacteria" id="AFU59856">
        <property type="protein sequence ID" value="AFU59856"/>
        <property type="gene ID" value="Ngar_c29380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29380"/>
    <dbReference type="HOGENOM" id="CLU_1063970_0_0_2"/>
    <dbReference type="OMA" id="PCEKKIA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2938-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="269" mass="29689" checksum="2E37413A5F97EAD0" modified="2012-11-28" version="1">MQRFAFIWAHENKQAVVLVLLSDLKQALYEAVSRSVPEAKIAVAFSGGVDSSLLAKICQDLAKQVTLVTVGFSGSHDIGFAKGIASKMGIECRTLEIDYRDFQENLRRIMQTINCGNTSHIENCIAYFYICKLAKQNGLDIVLSANGCDELFCGYDGYRRAYSGGEAAIMKLMDEKIANEFTLMAEVATVAGQFGVAVRQPFLSNKFIEFAKAIPVGQKIKGPDDMTRKHILRQAALSIGVPEESATKPKKALQYGSLIHKYFKKARNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF05</accession>
    <name>K0IF05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58355">
        <property type="protein sequence ID" value="AFU58355"/>
        <property type="gene ID" value="Ngar_c14190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14190"/>
    <dbReference type="HOGENOM" id="CLU_1709191_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1417-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="153" mass="14573" checksum="A9ED9C9BCA567E26" modified="2012-11-28" version="1">MRNNQIQKSYFLIPVSILLVSASIGIVTGSASALKPPVTQSQADVVNHATKGRVGIGVNQPANGQDVALGFADNGNNANANGGKFAAAFGGDGETDQDGGDGTANGDLVGLGFGGAGGPGSACHNGANGGDGRGTGGIFGGGFGGPGGRGGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF09</accession>
    <name>K0IF09_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57388">
        <property type="protein sequence ID" value="AFU57388"/>
        <property type="gene ID" value="Ngar_c04410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04410"/>
    <dbReference type="HOGENOM" id="CLU_2021573_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-440-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13606" checksum="359493A2EC473428" modified="2012-11-28" version="1">MNRSIDDVFDFFNDPMGMEIGGAAKSVTKDNDGSWTFDHSIAGESRIKHAPIREAGVLDHVFTGEGLEWNVYVRMIPNYGGTTVVWTFVKPDGLSDEQFGRQLRGFDPGIILWKQALEGGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF13</accession>
    <name>K0IF13_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c14290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14290"/>
    <dbReference type="EnsemblBacteria" id="AFU58365">
        <property type="protein sequence ID" value="AFU58365"/>
        <property type="gene ID" value="Ngar_c14290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14290"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1395"/>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_2"/>
    <dbReference type="OMA" id="NCRGYLE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1427-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="21646" checksum="49A896BEF80742F6" modified="2012-11-28" version="1">MAAQKQHDSLEKVAAEVRGCPLCKLSRSRKNAVPGEGQLSAKIMFIGEAPGKSEDEKGRPFVGAAGRVLDNLLEKAGIGRSQVFITNVVKCRPPNNRVPEEDEVTACRPYLDRQIALIRPKVICILGRTAYSSLLGGGSITANRGKIVERAGQKYFLTFHPAAAIYNKNLLSALEADLKKLANEIKKEEGKHSMEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF16</accession>
    <name>K0IF16_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">dnaK</name>
        <name evidence="7" type="ordered locus">Ngar_c30350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30350"/>
    <dbReference type="EnsemblBacteria" id="AFU59951">
        <property type="protein sequence ID" value="AFU59951"/>
        <property type="gene ID" value="Ngar_c30350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3005"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_2"/>
    <dbReference type="OMA" id="DKMVLQR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="623" mass="66223" checksum="80B73B4B86971838" modified="2012-11-28" version="1">MGKIIGIDLGTSNSAAAVMIGGKPTIIQAAEGTSIGGKAFPSVVGFTKDGQLIVGEPARRQMISNPEGTVIAAKRKMGTDFKFRVFGKEYTPQQISSFILQKIKRDAEAFLGETVDRAVITVPAYFNDNQRQATKDAGEIAGLQVVRIINEPTAASLAYGLDKANKDLKIMVFDLGGGTLDVTIMEMGGGVFQVKSTSGDTQLGGTDMDNTLVEYVVNEFKKQSGLDVRNDKAAMMRIREAAEKAKIELSNVVTTEINLPFLAYDPQSGPKNLILQLTRAKLEELLKPIIERCRQPMLQAMQDAKLTAADVDKIILIGGPTRMPMVRQFVASVMGKEPERGIDPMEAVAMGAAVQGAIIAGDVSTDILLVDVTPLTLGVEVLGGLKEPLIERNTTIPTKKSKVFTTAADYQTAVTIHVVQGERPMASDCVSLGMFNLSGIPPAPRGVPQIEVTFDIDANGILNVAAKDIATQKEAKITITANNKLSKDEIEKLKRESEQFAEADKKKKEEAEVRNEADNLIYAADKLVKQDLKDKVRPDQAERVNKLSQELRDAISSNNVDTIKAKIQELKNVLAEISTAAYQSAGATPSGTAAGPQAGAGGAGFAGGAGGSGGSAAGPNPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF46</accession>
    <name>K0IF46_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="4">IGPD</shortName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hisB</name>
        <name evidence="5" type="ordered locus">Ngar_c30700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30700"/>
    <dbReference type="EnsemblBacteria" id="AFU59986">
        <property type="protein sequence ID" value="AFU59986"/>
        <property type="gene ID" value="Ngar_c30700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30700"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3042"/>
    <dbReference type="HOGENOM" id="CLU_044308_2_0_2"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="21573" checksum="0085620FEFBBD732" modified="2012-11-28" version="1">MAAARKARIERVTKETAVTVQVNIDGTGKTSVRTGLSFIDHLITSIGKHAMIDIMLNGKSNDGIVHHLAEDVAIALAQTIDKALGDRAKIMRFGYALIPMDEALAYVSIDLVKRQYHKVELKLTRDSIEGMPREDLEHFVRSLVQNLNACTHMIVQYGDNDHHKVEAALKAFAVALRMATGIDSRRKGVPSTKGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFB9</accession>
    <name>K0IFB9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57528">
        <property type="protein sequence ID" value="AFU57528"/>
        <property type="gene ID" value="Ngar_c05850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05850"/>
    <dbReference type="HOGENOM" id="CLU_2613747_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-583-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9014" checksum="994F4011254E2939" modified="2012-11-28" version="1">MSATIYTLTKRSYNLILQKTAKKLTDGKRALFPDQAKIIRCYQCKEPLIIGKKIVSKTFGCQYRIHYCISCARLLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFJ4</accession>
    <name>K0IFJ4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57603">
        <property type="protein sequence ID" value="AFU57603"/>
        <property type="gene ID" value="Ngar_c06600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06600"/>
    <dbReference type="HOGENOM" id="CLU_182718_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-658-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10765" checksum="82DFF985589A3967" modified="2012-11-28" version="1">MHNVCVLPYGIPDDMDEVIITVTKNGQIIVPKKFREKHHIADRAIVVDTNQGVLIKPVPDPLAEIGSLKRLFKTSTSKKLLDEARSTEVSGKDRTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG64</accession>
    <name>K0IG64_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-aspartate dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">nadX</name>
        <name evidence="9" type="ordered locus">Ngar_c18470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11788"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11784"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the L-aspartate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18470"/>
    <dbReference type="EnsemblBacteria" id="AFU58780">
        <property type="protein sequence ID" value="AFU58780"/>
        <property type="gene ID" value="Ngar_c18470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18470"/>
    <dbReference type="HOGENOM" id="CLU_089550_0_0_2"/>
    <dbReference type="OMA" id="ECAGHSA"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01265">
        <property type="entry name" value="NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022487">
        <property type="entry name" value="Asp_DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020626">
        <property type="entry name" value="Asp_DH_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011182">
        <property type="entry name" value="L-Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="DUF108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005227">
        <property type="entry name" value="Asp_dh_NAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03855">
        <property type="entry name" value="NAD_NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="8">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF108" evidence="7">
        <location>
            <begin position="155"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="257" mass="26928" checksum="B7AE693FF754B546" modified="2012-11-28" version="1">MAVDSDKIANTSLVALFDVVEGNLQNLKSKLQRSSPGTHSDFGAFLASGADIIVEAASQDAVRTFGRAILEAGKDMMVMSVGALADRNLLAELLQVAAKKGCRIYVPTGAIAGIDAIRSVKHLLDSVTLTTTKSPKALAGAPFFETSKIKLDDVTKSTVIYEGVAAEAVRMFPANVNVAAVLSLAGIGVDKTRVRIVADPQATTNQHEILATGSFGEIRITVNNVPSPGNPKTSFLAVLSAIECLRSICDDGMRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGP6</accession>
    <name>K0IGP6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methionine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c10660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10660"/>
    <dbReference type="EnsemblBacteria" id="AFU58008">
        <property type="protein sequence ID" value="AFU58008"/>
        <property type="gene ID" value="Ngar_c10660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10660"/>
    <dbReference type="HOGENOM" id="CLU_065946_3_1_2"/>
    <dbReference type="OMA" id="CDKPVLL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1064-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="12501" checksum="7D92941C5CDBED7F" modified="2012-11-28" version="1">MSESASEQFITFEEFSKVHLKIGKVIHAESMQGMKKVFKATIDLGSEQRELAVGGALHYKPEEFVGRMVVVCTNLEPKKIGSIISRGMLLAADGPEGKPVFLTITEDAPLGATIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGQ5</accession>
    <name>K0IGQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58018">
        <property type="protein sequence ID" value="AFU58018"/>
        <property type="gene ID" value="Ngar_c10760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10760"/>
    <dbReference type="HOGENOM" id="CLU_1665553_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1074-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="158" mass="17298" checksum="A3778880ED987C28" modified="2012-11-28" version="1">MMLAKKQPTTRFAFILAILAAIFFVIGLPYLSHGEDYRNALIGGILSLVLIFTAFALTIRRGSGIVGFIMIIIGAFYVYYSHQSFRLLLNSIANTATNDGTSSLATLLSNVSGMVDYLFATVIVGTMMVALGTMTIVRYFRRTYLSEPVAYANTGRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR0</accession>
    <name>K0IGR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NUDIX hydrolase</fullName>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nudF2</name>
        <name evidence="2" type="ordered locus">Ngar_c10810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10810"/>
    <dbReference type="EnsemblBacteria" id="AFU58023">
        <property type="protein sequence ID" value="AFU58023"/>
        <property type="gene ID" value="Ngar_c10810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1024"/>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_2"/>
    <dbReference type="OMA" id="NRDPRGH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16726" checksum="71932E3270FF4A14" modified="2012-11-28" version="1">MRYSNPTPTVDIILQQGSKVLMIRRKKDPFKGQLALPGGFVNEGETAEDAMKREAMEETSLEVEPIDILGVYSDPRRDPRKHIMSVVFVGIIIGGSGKAGDDAEGIEWVELADIERQQFAFDHITILRDYKKWKASGGTFWSTKRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR4</accession>
    <name>K0IGR4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske [2Fe-2S] iron-sulfur domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c10860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10860"/>
    <dbReference type="EnsemblBacteria" id="AFU58028">
        <property type="protein sequence ID" value="AFU58028"/>
        <property type="gene ID" value="Ngar_c10860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10860"/>
    <dbReference type="HOGENOM" id="CLU_055690_5_2_2"/>
    <dbReference type="OMA" id="TLECWLH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1084-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12123" checksum="FBD3CE86DA02BE92" modified="2012-11-28" version="1">MPEEGEKWIKVCDDKALKNGDMLDFDHGDKKILLARAGGKVFATDRICTHAYADLSMGVMNEEEKTVTCPLHLSAFKLDSGVPQNLPAEEPLKTYKVKIQDNAIYIQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGS1</accession>
    <name>K0IGS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative creatinase</fullName>
            <ecNumber evidence="6">3.4.13.9</ecNumber>
            <ecNumber evidence="6">3.5.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepQ</name>
        <name evidence="6" type="ordered locus">Ngar_c11010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="6"/>
    <dbReference type="EC" id="3.5.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11010"/>
    <dbReference type="EnsemblBacteria" id="AFU58043">
        <property type="protein sequence ID" value="AFU58043"/>
        <property type="gene ID" value="Ngar_c11010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11010"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1043"/>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_2"/>
    <dbReference type="OMA" id="YCSDRTR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016980">
        <property type="term" value="F:creatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="135"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="359" mass="39440" checksum="8C6A8CE0C759C63F" modified="2012-11-28" version="1">MMKARRSAILQHARQAAGCSVVAAFEPENVFYLTGFWGEAIAVCTENGTKLIAPRLEYWRAEKTSIDCEVILTERGGELISTFVSQIKNSRACTDCSDYSTVESVRKQGGDIIVVNTEPFFQTRRIKDESEIRIIAKASRILDKLYGICEDEIKVGLSERDLQAKLIYEAMKMGANPPSYKSTLNPLIIAGGPNGALPHAEVTDRKFRKGDMIVVDLTLRHAGYIADATRTFALGSASTEMKKVYAVVQESQKAGLDAAKAGATCGQVDAACRDLIAERGYEKLFIHSTGHGIGLDVHEPPWLRMKNGEVLQPNMAVTVEPGIYLENKFGVRIEDSIIIVNNGKPQVLNRFTKDLVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX7</accession>
    <name>K0IGX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Mg-chelatase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21850"/>
    <dbReference type="EnsemblBacteria" id="AFU59115">
        <property type="protein sequence ID" value="AFU59115"/>
        <property type="gene ID" value="Ngar_c21850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21850"/>
    <dbReference type="HOGENOM" id="CLU_043779_0_0_2"/>
    <dbReference type="OMA" id="GMIPRAN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2183-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="544" mass="60608" checksum="0F4351E5BBCE5D47" modified="2012-11-28" version="1">MVHRSYTTKPKYTEIMPGVPEDYKQVKTLGDLLKINYKHVTVEEQMRGNLIAKLKKGEHPYPGIIGYDDDVIPAVNRAILSGHDLLLVGQIGQAKTKIAEAIAKNLLSPIPVVRGTVTNDIPTSIPEDQLTALLSDSEVVRTQPEFTVSPECEDIIRSNKLETKIDWISGADRYKYILSTPDISVKDLVGQIDAIKIAKKGVELYSMESYSAGQLLQARHGILCIDELPVLDPRKQVSLLSVLQEGKFTTGAYPAVFKPDVKIIATANPIDYTHSGKIIEPLFDRLRSHVDTHYPRTVEDEMLITVQESRIADAKNVMLPVFIVRTIAKITQMTRAHHDVNHNKGVSVRMSVHSMEMMIGEAERTRSITFGVKAIPRFCDIHCIHQSSKFELAEMEDTRENRKNVLDSIIESALKEVALEYIQKLAPEQLIKVKNDFAKNKAFQVSQALVGSGGISKSPDYESQLAKFPGLKAAVNETIGTVKDEQKQLVERAKQLGIRTDSILFTPDLNGEFTAAVTEVILEGLRHTQPPILDRKDNSYGLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGY9</accession>
    <name>K0IGY9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein family UPF0104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c21950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21950"/>
    <dbReference type="EnsemblBacteria" id="AFU59125">
        <property type="protein sequence ID" value="AFU59125"/>
        <property type="gene ID" value="Ngar_c21950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21950"/>
    <dbReference type="HOGENOM" id="CLU_820405_0_0_2"/>
    <dbReference type="OMA" id="WRIATYY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2193-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="359" mass="38390" checksum="F7168E5742B578BF" modified="2012-11-28" version="1">MNWRLVAIPVSIVPFIILFLTTNVSPQDVFAVGLVPFAASAAAEIARFMLQAVRFKYFIKRFIGYDVSSTGKTISARLAGEFVTQTTPSYVGGEFVRIAWLSRNGVPAGKAAWVATMEIIADVFVGSMLAFIAGAFAIYKGGSVAGIGIILVTIPTFAVWLAVVLFSAKRNLRLPSFSQRLAEKFLSKEKAENLVNTTNTAIADLCKMSRENFNSKKAIRTFAIGMAITFMAFVFHGLSFMVLANTAEDIGFFDSLMATSASVAVASLPITIGGSGLAELGIWAYISNLSGIPELGDVVSDPRLNVIIAWRIATYHVPLVIMWVAIMRLALGKVSTTSLGQPAAGNSPGSKPEDGNAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH19</accession>
    <name>K0IH19_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusA</name>
        <name evidence="7" type="ordered locus">Ngar_c01580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01580"/>
    <dbReference type="EnsemblBacteria" id="AFU57107">
        <property type="protein sequence ID" value="AFU57107"/>
        <property type="gene ID" value="Ngar_c01580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.157"/>
    <dbReference type="HOGENOM" id="CLU_131906_0_0_2"/>
    <dbReference type="OMA" id="TDQIKYI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="6">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="159" mass="17582" checksum="1C36CDDF4C65C9B3" modified="2012-11-28" version="1">MTEIKLTSDELRLMSLFQSVTSATARDCIVDEKMDRVIFVVNKGQMGLAIGKGGSTIKQLQNVVAKKIELVEFSDNPAEFIRNMLNADMVNDVRISDRSDGTKQAVVTVDQKKKGAVVGREGRNAEKARLLAKRYFQITNVQIVSPEQGSNSHRVNIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH28</accession>
    <name>K0IH28_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58133">
        <property type="protein sequence ID" value="AFU58133"/>
        <property type="gene ID" value="Ngar_c11930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11930"/>
    <dbReference type="HOGENOM" id="CLU_3039177_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1191-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="5891" checksum="BDC4ACEBF4001281" modified="2012-11-28" version="1">MEITIMLYDQDKKVVGLATSNTHVDTIHPDQTSSFETVLLDQIADISKKSAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH96</accession>
    <name>K0IH96_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58238">
        <property type="protein sequence ID" value="AFU58238"/>
        <property type="gene ID" value="Ngar_c13000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13000"/>
    <dbReference type="HOGENOM" id="CLU_2476118_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1298-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9797" checksum="DE1E734AE8F64FF9" modified="2012-11-28" version="1">MTDLVLEETYDRFVVLYDLLALVQQENATSESLAPAVHLSLGAVSQMLSFMLAQGFVKTVRSDSEFKITTLGSNFLRDFEGMRRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHK4</accession>
    <name>K0IHK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03090</name>
        <name evidence="2" type="ordered locus">Ngar_c03390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57257">
        <property type="protein sequence ID" value="AFU57257"/>
        <property type="gene ID" value="Ngar_c03090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57287">
        <property type="protein sequence ID" value="AFU57287"/>
        <property type="gene ID" value="Ngar_c03390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03090"/>
    <dbReference type="KEGG" id="nga:Ngar_c03390"/>
    <dbReference type="HOGENOM" id="CLU_3263937_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-309-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="41" mass="5023" checksum="8F12C0E2E522E000" modified="2012-11-28" version="1">MIEYLRRKFEETNDIRWLPTNISDFDRYNTFTVRLLGGPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT1</accession>
    <name>K0IHT1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57412">
        <property type="protein sequence ID" value="AFU57412"/>
        <property type="gene ID" value="Ngar_c04680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04680"/>
    <dbReference type="HOGENOM" id="CLU_2534788_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-466-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9569" checksum="71A9D1B8149E3DEB" modified="2012-11-28" version="1">MSKVGNLAENHCQLVEGCANLIIVVSRNYIWIKEMSTTPEMKVPVLEGKDAEEFQKYNSRVLTLEEKASLKKAHDFYKKHCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHW6</accession>
    <name>K0IHW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57492">
        <property type="protein sequence ID" value="AFU57492"/>
        <property type="gene ID" value="Ngar_c05490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05490"/>
    <dbReference type="HOGENOM" id="CLU_1292060_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-547-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="213" mass="24449" checksum="1C5103B810B87AC2" modified="2012-11-28" version="1">MRGKQNNLNHILNICQDGSSTNILQQLQSVTEQKVDKVDYQQQIERWNKYQELLDEIGKKCGRDVGVRLARNVKHNFNVFTDTSSAGLAVVGAAALLTLWGAFSIYSIYYLVGSIAALSFVGWQAFIRLHHPSVIHFKCSPALHIDEFAYMRQTIRGIPPAEHDPIVRLPVLEMSISRAWLAQQGMLKFMESLRDIKWERAEERSQQEHLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0II14</accession>
    <name>K0II14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c26430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26430"/>
    <dbReference type="EnsemblBacteria" id="AFU59565">
        <property type="protein sequence ID" value="AFU59565"/>
        <property type="gene ID" value="Ngar_c26430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2618"/>
    <dbReference type="HOGENOM" id="CLU_006533_0_3_2"/>
    <dbReference type="OMA" id="RRDYKRV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2643-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="536" mass="60894" checksum="21F158DC03984959" modified="2012-11-28" version="1">MEHPAQIRKDRSIDDETPVFPHPSKLHVAKVVLKLLPVVISLRRDRREWVKKEGKNVDEEKYRRHARKALKTFIELGPSYIKLGQWLSTRVDILPQPYLEVLAKLQDDVPPALFSEIKPIIEAELGKVEDAFEEFDTAPLSGASLGQVYVAKYAGRQVIVKVGRPNIERIIEDDIYVLKKIMPLATRFIDPNLRFSAEGMLAQFIETVHEEMDYRVEAQNLLAIKENLADDPSVIIPDVFMERTSRHVLTMEYVPGTKITDIARLEEKGIDRERLVVRAHWLFFKMLLRHNIFHADPHPGNISVADDGRLILYDFGMVGRLDSETRIRLIRLYLGLLDKDPERTVNVLIELGALEPTVNRYVVERGIELSIQSMHGKQVDRMEVKALVDLANKTMSRFPFRLPKNLALYMRMASILEGIYHHHKVPFQFVKVLANLLEEEGLVRDAYIEEVKVSAKRFAKGIQDSVNVAPLLKTYLETMGPYDRQDRSDNAALAASILASALFVGSAVMLPYSPYLAYGGFAAAAAAVAVTLRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0II21</accession>
    <name>K0II21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative archaeal preflagellin peptidase FlaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flaK1</name>
        <name evidence="3" type="ordered locus">Ngar_c06790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06790"/>
    <dbReference type="EnsemblBacteria" id="AFU57622">
        <property type="protein sequence ID" value="AFU57622"/>
        <property type="gene ID" value="Ngar_c06790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06790"/>
    <dbReference type="HOGENOM" id="CLU_1127120_0_0_2"/>
    <dbReference type="OMA" id="WIWIAMI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="2">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="27768" checksum="86817815BD924725" modified="2012-11-28" version="1">MLSILFIREILCFAMLSIGAYYDLKTREVDDGLWMVFGGAGSVLYAWEYVSGAMADAQIILVFISLTAVIALALYRYGFFGGADAKALVTISVILPVYYPLIPFYMHPITGITVLTNAVLFAMVVPLYNALSNLVKVARGERIFECLEEEPTWRKVLACFVGTPSNRPIRHHLVIEYSAGEGKKKKFSFRLNYGDDEGYGSSGNRSCYARSSTDSKRWLSQNLPFLLFMLAGFLATMLFGDVLLQVLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0II99</accession>
    <name>K0II99_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57717">
        <property type="protein sequence ID" value="AFU57717"/>
        <property type="gene ID" value="Ngar_c07750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07750"/>
    <dbReference type="HOGENOM" id="CLU_3163249_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-773-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="47" mass="5725" checksum="07F95236B0C4847C" modified="2012-11-28" version="1">MNEDEKPTLRLDRAYRCTTCDAVYLFPHEKEEHCRDTDHKEFIEILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG1</accession>
    <name>K0IIG1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09000"/>
    <dbReference type="EnsemblBacteria" id="AFU57842">
        <property type="protein sequence ID" value="AFU57842"/>
        <property type="gene ID" value="Ngar_c09000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09000"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_2"/>
    <dbReference type="OMA" id="YERYSLW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-898-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="408" mass="45458" checksum="06407DE8734BD249" modified="2012-11-28" version="1">MSISVGIITENPFHGDLGFSIRTRELSIGLANARCQVHVFSPVDQESEPYPNVFLHNISGKSNRNYDNIREFLRKWSKSKRYGRYFYLNSALSFISNQSAKMVYKSAKKYDLDLLQGTQATTSSVAIRVGKHLGIPVIGGMGGMLVEEAVQAEIFEQNSIFYNSCKRFVSSVIQNSAALICASEPMKKYLIDSYGVEGKKITVIPNGANIPEGERVKKSDGDYVILYAGILDIWEKVDVLIKSMPFVISRFPNAKLLIVGDGRLKNELTELVKNNNLDKSVSFLGLQPRKKTLEMMLEADVAVLPSSVDLVRKVACPIKLFDYMAAGLPIVTMDVGWWSDLVKSKNAGIVTADDPESFAEGICKAITEGHTTNNLLGYNARKVIAEEYNWKRISENLLQLYKSILDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0III1</accession>
    <name>K0III1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19210"/>
    <dbReference type="EnsemblBacteria" id="AFU58853">
        <property type="protein sequence ID" value="AFU58853"/>
        <property type="gene ID" value="Ngar_c19210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19210"/>
    <dbReference type="HOGENOM" id="CLU_101250_0_0_2"/>
    <dbReference type="OMA" id="FISHFIP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1919-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="25932" checksum="71C628200B59842D" modified="2012-11-28" version="1">MVTLDDLFPFDTELGYLGILIISFVASLIPFIPIPYFPLLITASFNSNFNPHLIALVSASGIVAAKTIIFFASYYGRKILSDQTKHRMRPLQKLVSRYGWFGAFIAALTPIPDDIVYIPLGLAKYNPWKFATATFAGKILMNEAIVWSSIFLGRPFVERILGETTDPTWLIVGAIASIAVVGVIIYYSLKIDWARIIGRWFPWALENGDNNNNDDDNDNNSKDDDEKKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK6</accession>
    <name>K0IIK6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28150"/>
    <dbReference type="EnsemblBacteria" id="AFU59735">
        <property type="protein sequence ID" value="AFU59735"/>
        <property type="gene ID" value="Ngar_c28150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28150"/>
    <dbReference type="HOGENOM" id="CLU_199455_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2815-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6219" checksum="B757E86741F225D2" modified="2012-11-28" version="1">MHHGKALESLTNHYKEWVDAYGGISWQDFLDRLSRMQETGSWVKEVIAVELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN0</accession>
    <name>K0IIN0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flagellar protein FlaG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flaG</name>
        <name evidence="2" type="ordered locus">Ngar_c10100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10100"/>
    <dbReference type="EnsemblBacteria" id="AFU57952">
        <property type="protein sequence ID" value="AFU57952"/>
        <property type="gene ID" value="Ngar_c10100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10100"/>
    <dbReference type="HOGENOM" id="CLU_108339_0_0_2"/>
    <dbReference type="OMA" id="ESIMIIV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="17828" checksum="92D23FE0CAAFF880" modified="2012-11-28" version="1">MKNSQMGSLIISEGIILIASIIIAAGFSVTVLNQMGVFKSTLATAGAAEKEIALTRIKILYATNSSSTQIDVWVKNIGTNQIVSLDKMDVYLGKLNNVQGIPYNAASPPKWTYTNSNGNVWQQKDSIKITVTLDYSLETNVNYLVRIATPNGVSDDYIFSLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ0</accession>
    <name>K0IIQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative archaeal heat shock regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c28910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28910"/>
    <dbReference type="EnsemblBacteria" id="AFU59810">
        <property type="protein sequence ID" value="AFU59810"/>
        <property type="gene ID" value="Ngar_c28910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28910"/>
    <dbReference type="HOGENOM" id="CLU_090889_1_0_2"/>
    <dbReference type="OMA" id="CTECYFS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2891-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="216" mass="24715" checksum="B026B12084A83A27" modified="2012-11-28" version="1">MDSGVILDILGNDTRRRILQLLSEEPMYFNQLAKEIGVGQQAILRHLVALEQGGIIETYSKKSDLGAPDRKYYKLNSSFMLRISLSEDDFTIENQAISETRQKRYESTPKSAGEALSHLQTSLLDVEKEISSIEDRLRDLYALRQQILHRLHQVGRDNFDSSERRVLYRIIEESPKSVAELSDLVDEKESSLRAMLASIANKIDEKSARLLFEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW0</accession>
    <name>K0IIW0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58062">
        <property type="protein sequence ID" value="AFU58062"/>
        <property type="gene ID" value="Ngar_c11200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11200"/>
    <dbReference type="HOGENOM" id="CLU_2893368_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1118-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="7551" checksum="21590972DCD953AD" modified="2012-11-28" version="1">MEQDIFRLLTLRIYDNKIEMYDRRKQQIVEVRIIDDLMMCLSCRTDECIHVGYALGVERLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY2</accession>
    <name>K0IIY2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59053">
        <property type="protein sequence ID" value="AFU59053"/>
        <property type="gene ID" value="Ngar_c21220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21220"/>
    <dbReference type="HOGENOM" id="CLU_1217617_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2120-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M10" evidence="1">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="25851" checksum="572C9AB06C48873A" modified="2012-11-28" version="1">MYRKLSLFALAAAFLVAAFNFSPALAARYYEDQTDFTETSVPVTRYSWDQGTIEGCIYKEDGIDNSYYVWTKLAVQKWRQALREYTSNLEAWSFTARYVRSEAALVSCDVKFYIYDTYKDFPDYPAQSGAYTSVRFSEGESGLDARVYLSPFVLHGDGKTEIDLPTYAFRNSAVHEVGHVLGLGHMQSQKGYLMSPQFDYWEQDDQLPITTLELDALVGVYGDDGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY4</accession>
    <name>K0IIY4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoA</name>
        <name evidence="7" type="ordered locus">Ngar_c11510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11510"/>
    <dbReference type="EnsemblBacteria" id="AFU58092">
        <property type="protein sequence ID" value="AFU58092"/>
        <property type="gene ID" value="Ngar_c11510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11510"/>
    <dbReference type="HOGENOM" id="CLU_119549_1_2_2"/>
    <dbReference type="OMA" id="LPMECGQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="13896" checksum="760B59FF17283425" modified="2012-11-28" version="1">MAGETAADFTPILYMLGFGLLASVPALVLSRLISPRRRYNPVKFLPMECGQMPTGEGRSHFMMQYYAYILMFVVFDVMSIFLYAWGTALFNIPRAATLPIIGFLGIMFAAMGYALYLSGRKGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ51</accession>
    <name>K0IJ51_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">uvrA</name>
        <name evidence="16" type="ordered locus">Ngar_c12620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12620"/>
    <dbReference type="EnsemblBacteria" id="AFU58202">
        <property type="protein sequence ID" value="AFU58202"/>
        <property type="gene ID" value="Ngar_c12620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1208"/>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_2"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="597"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="643"/>
            <end position="650"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFU58202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="954" mass="106569" checksum="C6DF34C631349F2D" modified="2012-11-28" version="1">MHDKIIIRGARQHNLKNINVEIPKNKLVVITGLSGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLELMDKPDVDSIDGLSPAISIQQKTTSKNPRSTVGTVTEIYDYLRLLFARIGIPHCPKCGRKIASQSADSITESVMKIGDGKSVMILGPVVQAKKGTYEKLFDQLKQDGFSRIRLDGEITNLDEDDEEKPQYPRLDKQKKHTIEVIVDRLKPSVEEKSRLFDSIQSALKVGNGVVVVSIDSKDAMYSQRNACPHCGISLGDLEPRTFSFNSPFGACKDCNGLGIKIEFDPDLIIPDKTKSILDGAIKPWTGHFATFRSAMLRDVGRKFGFDLATPISKMKPDQLKVILYGTDQSIHYKYESRYSESRWEYRGTFEGVIPNLERIYRETESESKREDLMQFMRERPCERCNGRRLRDEALAVKIQGKSIMEVCDLSIDECYKFFQNLALSETERYIARTILKEIISRLEFLRNVGLNYLTLNRMTATLSGGESQRIRLATQIGSNLTGVLYVLDEPTIGLHQRDNARLIDTLKKLRDLDNTLVVVEHDEEVIRSSDWIIDIGPGAGIHGGAIVASGQLQDIMKNPDSITGAFLRGDRLVAHQHERRKSSKWLTVHGARENNLKSIDVRFPLGCMTVVTGVSGSGKSTLVNDILFRALAEHFYDAKYRPGKHDKISGLEHVDKVIGIDQSPIGRTPRSNAATYVNAFTPVRELFAKTSQAREMGYKAGRFSFNVSEGRCEACEGGGVKKIEMQFLPDVYVTCDECKGRRYNSETLLIKYKGKTISDVLDMTVEEASEFFSNIPAITKKLQTLNDVGLGYLRLGQPATTLSGGEAQRIKLAAELSRRDTGKTVYILDEPTTGLHFADVSKLLNVLKRLVDLGNTIIIIEHNLDVIASADWIVDLGPEGGEAGGRIVAEGTPEQISENQDSYTGKYLKPKLAVDQKILQRTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ61</accession>
    <name>K0IJ61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60045">
        <property type="protein sequence ID" value="AFU60045"/>
        <property type="gene ID" value="Ngar_c31290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31290"/>
    <dbReference type="HOGENOM" id="CLU_2911656_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3129-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6679" checksum="ABE9F34ED7A271FD" modified="2012-11-28" version="1">MYVKNCCPNQRSGTTTNAMGINALVADLFTIVTSPVPTTNAYFHFIMENATIAGYDSQLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC0</accession>
    <name>K0IJC0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58352">
        <property type="protein sequence ID" value="AFU58352"/>
        <property type="gene ID" value="Ngar_c14160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14160"/>
    <dbReference type="HOGENOM" id="CLU_2875204_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1414-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7220" checksum="79D77AFDF0C7945A" modified="2012-11-28" version="1">MMVPSLTPLQINVIVRYLERSGAIVIDTEGYIVWTRKEQKQLTLGEVAEISGDLREFLEKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM1</accession>
    <name>K0IJM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60240">
        <property type="protein sequence ID" value="AFU60240"/>
        <property type="gene ID" value="Ngar_c33250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33250"/>
    <dbReference type="HOGENOM" id="CLU_1381450_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3325-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="202" mass="21655" checksum="22E562377217659E" modified="2012-11-28" version="1">MKHARKSTSQRFRPRLAVTGSGLAAGLISSLAISALLLLVERVSELPVGTFYLVLAFALLQTEEHTIGMVALGFLMHLAAGSVIGLAISVPFSASRRLFAAGGKYAPAYGLAAGFVLWSALFLPITYGIMLPLLNAADSQAVMIRQKVPTGEAYTVAMGELLAMMDRVVVGALAFNMFYGLLAVTLSRSLYEAYLRRNRIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN2</accession>
    <name>K0IJN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33450"/>
    <dbReference type="EnsemblBacteria" id="AFU60260">
        <property type="protein sequence ID" value="AFU60260"/>
        <property type="gene ID" value="Ngar_c33450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33450"/>
    <dbReference type="HOGENOM" id="CLU_1297523_0_0_2"/>
    <dbReference type="OMA" id="WVGFNLP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3345-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="23738" checksum="CDAB2DF7030004AF" modified="2012-11-28" version="1">MSSGEILQELLQDHPYLWVLLIIFGVSAAPILTPPTWMVIVSANALSDYSLNPLLLSSVGATAATSGRMLLLKYSSIGRRRLNEKRKSSLERLRDYLQKTRYGYFASTFIFALTPLPSNMLFISYGLMNARSFLGIVAGFWIGRFAVYLLMIYVSGFVYQPISQILGDNLTAVIITDIAGMGMTVAILMVDWDRAISERKIALIRPRFLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJR3</accession>
    <name>K0IJR3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AmoX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59458">
        <property type="protein sequence ID" value="AFU59458"/>
        <property type="gene ID" value="Ngar_c25360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25360"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2514"/>
    <dbReference type="HOGENOM" id="CLU_165871_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2535-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="7937" checksum="8C349F3F075D93C6" modified="2012-11-28" version="1">MIGRRVENMNGIYILGFALCWAATAGGVYVGVAVYPWAYPLPSGIYALSVLTVIEALGFFFIMKIAHEKPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKJ0</accession>
    <name>K0IKJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58967">
        <property type="protein sequence ID" value="AFU58967"/>
        <property type="gene ID" value="Ngar_c20350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2012"/>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2033-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="19772" checksum="29815967C39E0548" modified="2012-11-28" version="1">MPIDADFPKNHQVIGKHQHSDGEHFHFVWGPGRYAEAAENEEVKKAYEARGEQLVPLGVHGTMVALDWDSCIADGACIEACPVQVYQWYRSEQDVPGIEMQNATSAGTGEDHSRDGRKDYTDKSDPIREHDCIWCMACVSVCPTQAIKVDQSNLEFHEKAAGTFNEALAKGSAPPPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK9</accession>
    <name>K0IKK9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c29040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59823">
        <property type="protein sequence ID" value="AFU59823"/>
        <property type="gene ID" value="Ngar_c29040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29040"/>
    <dbReference type="HOGENOM" id="CLU_122242_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2904-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="154" mass="16781" checksum="AC189B8E4E1522F6" modified="2012-11-28" version="1">MGNGAQARRAMMSKEQVAQTLKDIARRIREESVRMKETVRFMRESGAIEELTDAVKEATIAARDASKEINQTARELKERGIIRDTATAVDETTRTAKDTVQTVSEISEEARQAAPETAAGVAKAAETVKEDTRVAAEKAREKLTKGEGEATTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ2</accession>
    <name>K0IKQ2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29850"/>
    <dbReference type="EnsemblBacteria" id="AFU59903">
        <property type="protein sequence ID" value="AFU59903"/>
        <property type="gene ID" value="Ngar_c29850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29850"/>
    <dbReference type="HOGENOM" id="CLU_065947_2_2_2"/>
    <dbReference type="OMA" id="GYRWGSC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2985-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="27102" checksum="2F07CD92DD66ED5C" modified="2012-11-28" version="1">MILSLDHAGGAIKIDVLTSKRAKRLRLVSGINGVQAIVPPDYRVEELESFVSAKRDWIIKTSRYYIRLKERCGGGHEPGTIYFLGSKYRFHIVRDRQRSAVVSDAMKVITFHVTDRRKYKEEMQEWYKEQTGKIISERLPALAARLNLQYNKVSIKSQRSRWASCSKKGNLNFNLLLAAAPREVIDYVIIHELMHLIEMDHSIRFWQLVKEADPDYKKHKEWLTSYAPVIKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ5</accession>
    <name>K0IKQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21720"/>
    <dbReference type="EnsemblBacteria" id="AFU59102">
        <property type="protein sequence ID" value="AFU59102"/>
        <property type="gene ID" value="Ngar_c21720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21720"/>
    <dbReference type="HOGENOM" id="CLU_1088211_0_0_2"/>
    <dbReference type="OMA" id="RETGNTM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2170-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="245" mass="27852" checksum="89DB16C53D6D7657" modified="2012-11-28" version="1">MNFRFIHVYSDDVSIDAKAVAGEITKIFPSCKVDVRPAFKYDERRIELARIADIKQPFEKQPRQKTSDTAMMPPIYDGFALQRIFAETISAAEADHMHLIFTSLLACTFSEDDWRYHARTVICGSPSLISTAGIVEGPAKPREFYLAQLGGVAVDTNLKKRFAGRFIDYGDDKMMTAAAAIYTLQALFFFVTDGELFCKEKSCMLYNAHWQEELIYLIEKGALCAHHRQMASKFNKNNRSVKESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT9</accession>
    <name>K0IKT9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22320"/>
    <dbReference type="EnsemblBacteria" id="AFU59162">
        <property type="protein sequence ID" value="AFU59162"/>
        <property type="gene ID" value="Ngar_c22320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22320"/>
    <dbReference type="HOGENOM" id="CLU_156337_0_0_2"/>
    <dbReference type="OMA" id="CKECENM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2230-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="15056" checksum="1070225EAC502E8E" modified="2012-11-28" version="1">MLLPSEIEAKSLIPAVRAILAKKLIKEYSLKEEDVAKVLGITQAAVSNYVRGTRGDIELISKLESVREVMRMIDDIAKDLSTNKAYTPSTLAKFVGLCNYMRYTLIICDVHHSIESNIDETICEQCRGTLVREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKW2</accession>
    <name>K0IKW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60028">
        <property type="protein sequence ID" value="AFU60028"/>
        <property type="gene ID" value="Ngar_c31120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31120"/>
    <dbReference type="HOGENOM" id="CLU_2930318_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3112-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6669" checksum="F7EDB177205B24B9" modified="2012-11-28" version="1">MACNSCGHPNDAHQYVTSSLFYCSECKVLESHIAFSQEQAKGNPPKSDDVLSDVYNAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL33</accession>
    <name>K0IL33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59297">
        <property type="protein sequence ID" value="AFU59297"/>
        <property type="gene ID" value="Ngar_c23720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23720"/>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2370-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="10979" checksum="B9B853D229441BE5" modified="2012-11-28" version="1">MRPLLTREESELSIMQALIRMSTRRTLEAKLGRTLYSTTVYENVKRVTISLLFANGGENDATTYLMVSFEKDANHEEIITTKILPFLRNAGRQQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL46</accession>
    <name>K0IL46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60148">
        <property type="protein sequence ID" value="AFU60148"/>
        <property type="gene ID" value="Ngar_c32320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32320"/>
    <dbReference type="HOGENOM" id="CLU_1292062_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3232-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="213" mass="22529" checksum="DCEA278F47D13B9A" modified="2012-11-28" version="1">MNMLAASLLLLPLAAAFALLYGPAVQASLNPGNELMTASNYTFQSDTFSTDGAIGSVAGDQVDPVIITGRWSLDVQGGVVADFSANLTMVNASGAGYRTVELSNLSSTEVTMDENGTALIKGVLDVIVNSTEKLSDVDVVIKLAKLRALNMTLSEPDYYLDDGPIYGTADQQQQQQQETTTTAGSAGLMPEGSGIFGKITEKFRLPQLPNPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL91</accession>
    <name>K0IL91_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60248">
        <property type="protein sequence ID" value="AFU60248"/>
        <property type="gene ID" value="Ngar_c33330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33330"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_2"/>
    <dbReference type="OMA" id="SRRDECI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3333-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="132" mass="15079" checksum="550EC09E20A56193" modified="2012-11-28" version="1">MSAAVTTGRKLARLLYVDDEVDILNVVKVSKNHGFSVDVATSAEQALAMDLRSYDMIVIDIRMPRMDGFQFYDAIKSKVDDAAKTKVCFFTAFTSYQEEYQRRFPTWNGCCFITKPMSVRLLAEKLRELLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB1</accession>
    <name>K0ILB1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c24800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24800"/>
    <dbReference type="EnsemblBacteria" id="AFU59402">
        <property type="protein sequence ID" value="AFU59402"/>
        <property type="gene ID" value="Ngar_c24800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24800"/>
    <dbReference type="HOGENOM" id="CLU_626453_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2478-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="78"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="213"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="437" mass="47988" checksum="2036E43C67D4F588" modified="2012-11-28" version="1">MIKPLSNRRAIREEREITKIVTKIIIGFLAVAALATGAVGYYMQQSLAGAGAAATTGLVIVIIIVAAAIGAIGALLAVFILLPVRKIEQSAEQIARGNFEVQVYNGKLTKGSYKNSDELVRLMMAFEVMRRKVTEVDANLNKQIKMKTFDLQRINDELVEKEKVLQRANARLTGQSEDLKKMNEELSAKNKELSEANEKLQRLDKMKTDFILVAAHELRTPIQPIMGSVKLAEKGLISNEQAWKSIVTEAKRLSTVATYILDVGKIESGNISYDMKPLSVSELVERISSSSTKFATQDGMISIKIDLDEDVRIMGDRERLVQAFANIIDNAAKFAKNGTITIQTINNDDEGVVEIKIRDDGPGIPDEIMPVLFNKFVTKTKENERGTGLGLFITKSIIEAHSGKISAENNADGKGATFTVSFPIHEKGEVASMSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH3</accession>
    <name>K0ILH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60418">
        <property type="protein sequence ID" value="AFU60418"/>
        <property type="gene ID" value="Ngar_c35050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35050"/>
    <dbReference type="HOGENOM" id="CLU_932615_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3506-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="298" mass="33762" checksum="7F65955DE00A86D5" modified="2012-11-28" version="1">MNSPMFVSANIPPNFERNLDTNRTITVSQMVYSRKARGSKKSPVPDDREATEAFGINGSKTRIRRKYPTNSCQIGLSASSLFKFCNAPLRLVALDLLCFTKSNVVSPTMTARVIPKRARKLLTTDKTDHRNNRSDASIIAFPIWSGLSKPFFIQTPINQSIIDAKKLGKIVCQRCGSENYERSGIRHNKKAGDIQRYICKDCHYRFTFNPAFENAKASARVISAAIDLYFKGMSFRKISEHLQSEGTEINYASVCRWIRKFNKVVQPYVDSFVPSQLSGVYHVNECFCTSETKRTMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI8</accession>
    <name>K0ILI8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobM</name>
        <name evidence="7" type="ordered locus">Ngar_c35350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35350"/>
    <dbReference type="EnsemblBacteria" id="AFU60448">
        <property type="protein sequence ID" value="AFU60448"/>
        <property type="gene ID" value="Ngar_c35350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3540"/>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_2"/>
    <dbReference type="OMA" id="WSAMGEQ"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="29134" checksum="AAE4D198128CCAC1" modified="2012-11-28" version="1">MPESSNTVYFVGSGPGDPELITLKAKKLVEQADVIIYSGSLFNPKNLEYARKDAKLYDAAVIDREKIYQILRDSAKEGKLAIRFHDGDPALFSTIREQIDKLEADGIKCKVVPGVTAILGAAADLNLELTLPGITQTLIVTRAELRTPVPARESIAELAKHGATMVFYLSVHLIGDVVKELLKGGVYTENTPAAVVYRATWEDEKIIKGTLGDIAKKTREAKIIKTALIIVGDVIAPAKYEYSKVYDAGFTHGYRKAVVKEEEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP3</accession>
    <name>K0ILP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57189">
        <property type="protein sequence ID" value="AFU57189"/>
        <property type="gene ID" value="Ngar_c02410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02410"/>
    <dbReference type="HOGENOM" id="CLU_204309_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-241-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6379" checksum="6CB5F38737DF6369" modified="2012-11-28" version="1">MECIAEDHVIKPKYRSISGRVRLRCNDCGKEHEVILKHKIAKFVGASPSFKEISHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ9</accession>
    <name>K0ILQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57249">
        <property type="protein sequence ID" value="AFU57249"/>
        <property type="gene ID" value="Ngar_c03010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03010"/>
    <dbReference type="HOGENOM" id="CLU_2379501_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-301-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10673" checksum="81725424CF72AEAF" modified="2012-11-28" version="1">MQTNNTVSPSLFLGGTPKKIGKKAFVSQVKKVLESAEVSWLTTDIRSFEWSEINLDKRKFLDELSSLNFKTAHIGIFYPESKKTEYNVFQIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILS7</accession>
    <name>K0ILS7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57299">
        <property type="protein sequence ID" value="AFU57299"/>
        <property type="gene ID" value="Ngar_c03510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03510"/>
    <dbReference type="HOGENOM" id="CLU_2784234_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-351-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="8180" checksum="8C9B573960F27F0F" modified="2012-11-28" version="1">MKHVCSGIKHKHKGALRQTRHPYYIYENWCETCHYAYQKKFRVCPCCKRLLRTKSRDKPKAHTPALSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM61</accession>
    <name>K0IM61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dephospho-CoA kinase, CoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06460"/>
    <dbReference type="EnsemblBacteria" id="AFU57589">
        <property type="protein sequence ID" value="AFU57589"/>
        <property type="gene ID" value="Ngar_c06460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06460"/>
    <dbReference type="HOGENOM" id="CLU_096329_1_0_2"/>
    <dbReference type="OMA" id="DYMIVNE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-644-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="20535" checksum="8789FC85F1C0F762" modified="2012-11-28" version="1">MSKRLIICLTGMPGAGKSTVASFLKEKGFTAVTMGDAVREEAKRQGLEPTDVNLGKLMIKLRQDLGQGAVAHLALQKLARDGSRGNVVIDGIRSIPEVEVLKQVGYVKLLAIHASQDTRFKHLVDRGRSDAPANSDEFAGRDKRELSVGISEAIALADETISNNGLTLNQLKQRVCDIVKEWLEEAKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI0</accession>
    <name>K0IMI0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aspartokinase</fullName>
            <ecNumber evidence="3">2.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c33870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33870"/>
    <dbReference type="EnsemblBacteria" id="AFU60302">
        <property type="protein sequence ID" value="AFU60302"/>
        <property type="gene ID" value="Ngar_c33870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3380"/>
    <dbReference type="HOGENOM" id="CLU_579551_0_0_2"/>
    <dbReference type="OMA" id="MFGMKIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3388-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="477" mass="53342" checksum="C71E7141AD47075A" modified="2012-11-28" version="1">MTSITVAKFGGSALGIEGNMIPKIIDRIRQLQQESKVVAVFSAPLIEYDGKVSSMTDVALKVGRSYAASTPVEIEVLREVYERIASKYVKEEGGRQEFIDSLDKFYRQVIISLKQAAENRRFVDVIRSRTLAYSGEVTMSYLMDYVMQSAGLKSTHVSIEKWPIITDDNFEAANFMVQESKEHSGHLIDLVEHNDVVSMGGFIGRTVDGLETTYERGGSDRTAADIAILLNDSYDVKIDFEKDSAVLSADPRIVKDDLEFIQYLSYNEAKLAGMFGMKILDPIAIKEIDDNNLDIPIVITDMAKPGGMTMIQRKPPVDSSGNDNPIKIVTGKKNCAMVRMESNAASHLVASLELDRQYHDFVKLSPYKVDDTEMTRLLFLDADYVRRYERHFRAYYPKAEIVYGRGVVTLIGDEMWKVPKIASTASSTVSEHDINILNLDAQEETSRILIVVEDKGSSVADAVKAIHSTRTKIRGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ8</accession>
    <name>K0IMJ8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="2">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">rlmE</name>
        <name evidence="5" type="ordered locus">Ngar_c34370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34370"/>
    <dbReference type="EnsemblBacteria" id="AFU60352">
        <property type="protein sequence ID" value="AFU60352"/>
        <property type="gene ID" value="Ngar_c34370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34370"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3435"/>
    <dbReference type="HOGENOM" id="CLU_009422_4_4_2"/>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FtsJ" evidence="4">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="198" mass="21598" checksum="00B693F9C0D47984" modified="2012-11-28" version="1">MRLIDARRDQYRRLAKDQGYRARSAYKLLQLNSSYRILKKGSKVVDLGCAPGGWLQVATKEVGQAGKVVGIDLKPVEPVLGATVLEGSIEDPAMLEKIAGILDGGKADVVLSDLAPNVSGVWDVDHARQISLSTIALGFARQILRAGGSAVFKVFEGDMLNEFRAELKKSFGRVFLSKPSASRQESSELYIVCLDFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM0</accession>
    <name>K0IMM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c34890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34890"/>
    <dbReference type="EnsemblBacteria" id="AFU60402">
        <property type="protein sequence ID" value="AFU60402"/>
        <property type="gene ID" value="Ngar_c34890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34890"/>
    <dbReference type="HOGENOM" id="CLU_150443_0_0_2"/>
    <dbReference type="OMA" id="GEMGRAN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3490-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="15524" checksum="9D331AF81A14D897" modified="2012-11-28" version="1">MAKEKTAHAQVPPPTSHSAVEAIVSALSELEGDIDGLYSRVEEMKKRIMAHSNEEVEKLKQQVIAMANEEAKQIVDSARAEAEAESEKIGEMGRANVANLKKNINSSFDEAVDSIVRTVLGDTTPVKAAQPAKAKKLTSDGKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ6</accession>
    <name>K0IMQ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coenzyme PQQ synthesis protein c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11630"/>
    <dbReference type="EnsemblBacteria" id="AFU58104">
        <property type="protein sequence ID" value="AFU58104"/>
        <property type="gene ID" value="Ngar_c11630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11630"/>
    <dbReference type="HOGENOM" id="CLU_088144_0_0_2"/>
    <dbReference type="OMA" id="ACAMYAF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1161-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="74"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="275" mass="31346" checksum="47520EDFB86E6F56" modified="2012-11-28" version="1">MNPGSATRKATMLDRTVQPQKWLLHHRSTRKLCKNLPIKSFLGCFFTRFFYRVELRSPMNIVQKIDSEIERRSLLKHSFYQMWSEGKLTIDHLRGYSLEYFQLVKAVPKFVESIAAKAMDNKDIASNAREEAEHIEPWVRFAGALGVPRSDLVDYAGAAKTDAAVAKMMTLANASFEEAVAAMYAYEMELPKISRSKIDGLKKFYGMSSGDATKYFEIHEEADVRHARVWREILDKIPAEKQEAAFAAAVESLKAQNMLLDSVQERYVGSSRMNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT8</accession>
    <name>K0IMT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12590"/>
    <dbReference type="EnsemblBacteria" id="AFU58199">
        <property type="protein sequence ID" value="AFU58199"/>
        <property type="gene ID" value="Ngar_c12590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12590"/>
    <dbReference type="HOGENOM" id="CLU_2243943_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1257-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11553" checksum="663613793886668C" modified="2012-11-28" version="1">MAGELPSFWSQLGFVFGKFPFVGSHLRELIKLLHARLSSNAFFGFEITATVAVAAAVTSKSKAFDSSIKILDFSRYAGLLVCFDSRDFIFPESKFKTMQDNITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU5</accession>
    <name>K0IMU5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyridoxamine 5'-phosphate oxidase, FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12960"/>
    <dbReference type="EnsemblBacteria" id="AFU58234">
        <property type="protein sequence ID" value="AFU58234"/>
        <property type="gene ID" value="Ngar_c12960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12960"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1243"/>
    <dbReference type="HOGENOM" id="CLU_067890_2_0_2"/>
    <dbReference type="OMA" id="AKFGQNM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1294-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="24280" checksum="3E476CFD54BD75CF" modified="2012-11-28" version="1">MQLVKKYEIQSKQKIIDFLNSQPAGRIASIDKDGYPQVIPMNFVYFNDAIYMHSHPFGEKLDNIRRNPSVGFEVDQHVCFLPSYYFHPTDASQADTLYISVVIKGRAEIVEDREEKAKALNALMEKYQKEGRYEALDAEMPVVEEVAIIKVIPSDMRGKYKIGQHWARPYRLKMAKNIIMREGLENAKPVLAIMGIKVASDGNLEIEQDPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV3</accession>
    <name>K0IMV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58274">
        <property type="protein sequence ID" value="AFU58274"/>
        <property type="gene ID" value="Ngar_c13360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13360"/>
    <dbReference type="HOGENOM" id="CLU_092801_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1334-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23157" checksum="63CCA7AE4BECBE8A" modified="2012-11-28" version="1">MSTVQIPKWNIKADYVETCNCDYGCPCNFNGFPTYGFCRALVLYHIKNGSYGNTKLDGIDVIYAASWPKAIHEGNGTMQLFIGKKATEDQRKAIVNIFSGKAKGEGSFAIFANTFKYMLEPQFVDISAKIDGKKSSFSVPGIIDVRIESFKNPVTGEEQDTRIQLPNGFIWKVAEAAKSKMMRILTPNLNFDESGKNAFFSVVEYKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ0</accession>
    <name>K0IMZ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rps8e</name>
        <name evidence="5" type="ordered locus">Ngar_c15250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15250"/>
    <dbReference type="EnsemblBacteria" id="AFU58459">
        <property type="protein sequence ID" value="AFU58459"/>
        <property type="gene ID" value="Ngar_c15250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1486"/>
    <dbReference type="HOGENOM" id="CLU_080597_2_1_2"/>
    <dbReference type="OMA" id="NPNYVRR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_S8e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="PTHR10394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="14566" checksum="54C1635E5E7C0AF7" modified="2012-11-28" version="1">MRKSIENLAGRKMTGGRKVAMRGRRKFEIDRYPNEAVVGPTQIVARRTRGNNIKAAFKTAEFANVVDKEAKKVTKSKILKVNKNPANRDYERRGVISKGAVIETESGTAVVVSRPGQDGVVNAVLVKAAAAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN42</accession>
    <name>K0IN42_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein Ngar_c17860</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c17860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17860"/>
    <dbReference type="EnsemblBacteria" id="AFU58719">
        <property type="protein sequence ID" value="AFU58719"/>
        <property type="gene ID" value="Ngar_c17860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17860"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1762"/>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_2"/>
    <dbReference type="OMA" id="RGCIGFP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1784-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="204" mass="23016" checksum="DC6D599E6954E095" modified="2012-11-28" version="1">MNCRVLISDSEGAELVRLARKAVETYLRESVIIQPEQDAGRAAGVFVTLNYLTRNKEEHLRGCIGFPLPEKELYQSVVEAAIAAATEDPRFPPVDKQELDSIIFEVSVLTPPEEIRTKSAADYRKEIKIGRDGLVLRWRYGSGLLLPQVPVELKWNVDQYLANICYKAGAPADAWLDPASKLYRFQAIVFKEVEPRGKVTRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN56</accession>
    <name>K0IN56_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18570"/>
    <dbReference type="EnsemblBacteria" id="AFU58789">
        <property type="protein sequence ID" value="AFU58789"/>
        <property type="gene ID" value="Ngar_c18570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18570"/>
    <dbReference type="HOGENOM" id="CLU_130837_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1855-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021513">
        <property type="entry name" value="Phage_RSL1_Orf186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11373">
        <property type="entry name" value="DUF3175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10522" checksum="2B04BFBA13E9087C" modified="2012-11-28" version="1">MPPARKKNSKGKKRWVSKVTTESTFPKKGIFTKDAETIARHMASKKVSPKGIGSGIRMIQYFINRAGRSLPASRRRELEKAKRILQARQKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA4</accession>
    <name>K0INA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative succinate dehydrogenase/fumarate reductase</fullName>
            <ecNumber evidence="8">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhC</name>
        <name evidence="8" type="ordered locus">Ngar_c20980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.1" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20980"/>
    <dbReference type="EnsemblBacteria" id="AFU59029">
        <property type="protein sequence ID" value="AFU59029"/>
        <property type="gene ID" value="Ngar_c20980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20980"/>
    <dbReference type="HOGENOM" id="CLU_150446_0_0_2"/>
    <dbReference type="OMA" id="HRVTGFI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16112" checksum="977E6DF6C8EFA602" modified="2012-11-28" version="1">MEVADRNNREGMKGWLNPGRYGWERVSYWLQRLTGVGLLAYFVAHIYETSSLTHGPDAWAAMLELTQTPMGHLILILVIGMSTFHSANGIRLIFTHGGKGLGKPGRPDYPYDAVSLNYRQKSGIWIALILAAVAMLYGASVLFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0INE5</accession>
    <name>K0INE5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c23080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23080"/>
    <dbReference type="EnsemblBacteria" id="AFU59234">
        <property type="protein sequence ID" value="AFU59234"/>
        <property type="gene ID" value="Ngar_c23080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23080"/>
    <dbReference type="HOGENOM" id="CLU_011276_8_2_2"/>
    <dbReference type="OMA" id="TFISTED"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2306-MON"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="25261" checksum="5CDB0B3E4CF39A99" modified="2012-11-28" version="1">MIVDLNVKGKRAIVIGGGTEGVRKVRGLLGQGCKIIVISNRVNRFLSDQAALGKIELVKAKLCDAKILDNYSDDNVFLVLAATNDRELNRMIVEKGRSMGAFVYAADDPEVSDFSYASIVNIEGVMQVAISTSGKSPIMARKVRIRAERVLRRIIKKADIENAKLQEFARQAARPRIKTVGERKEFLYSLIKDKRIQNLIKEDRIEDAKSATLELLQKWERKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING3</accession>
    <name>K0ING3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mechanosensitive ion channel MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS2</name>
        <name evidence="8" type="ordered locus">Ngar_c23990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23990"/>
    <dbReference type="EnsemblBacteria" id="AFU59324">
        <property type="protein sequence ID" value="AFU59324"/>
        <property type="gene ID" value="Ngar_c23990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23990"/>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_2"/>
    <dbReference type="OMA" id="RIGFTVI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="294" mass="32439" checksum="462D9A6C19F6908A" modified="2012-11-28" version="1">MFGIPVELLTILLTIVIIVAGFVIAHSVRIVTTRYLGSHLPPDTRKTIGRISYYVIIAIALFSALGVSGIDLSGVFLAGGIAGIVIGFATQSLFSNLISGIFLQVDKPMKIGDPVLITGKLPDVAGIVVEITTLSSRLRMFDGTYVRLPNSDVFLSEIRNFSGAAARRVEISVRIAYREDTTKVVEMIRKSLRETPLVLIEPEPDIYVDSLGDSAVNINVWCWVPFSVWFNMRKQLVEQVKKELDANRIEIPLPQRIVYLADRSHSRKGGSSLGVSSGEIHEGLNIDEYMHQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP9</accession>
    <name>K0INP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c28340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28340"/>
    <dbReference type="EnsemblBacteria" id="AFU59754">
        <property type="protein sequence ID" value="AFU59754"/>
        <property type="gene ID" value="Ngar_c28340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28340"/>
    <dbReference type="HOGENOM" id="CLU_027562_2_1_2"/>
    <dbReference type="OMA" id="LNKFAGW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2834-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="343" mass="38710" checksum="66D6181E80327377" modified="2012-11-28" version="1">MRSIISDKKYAGKTNRAFAEAIKRLVHFAKAGEIGEKRDGRDYVPEVSWIRPEVYVKNGRKREIRPGDLLTGEEIEALLDAIPKISRFPGRDRAMVMCLYEGAFRPGELLNMTVGGVLFKDKVAVVTTVGKTGEKTVPLLLSYRLLLDWIEQHPFKDNLDAPLWWSFATGKGVGYGYLRKVVKKAALEAGIKKKVWNYLLRHTKLTDVAKKHPDQILKRFGNWKKGTEMMDVYIHLSESDLEEAVLKEHGLLPEGGKKNGLALKTCPRCGEQNAGAKRCTKCGYIIDEKLAIKITQREQSTLEGLTRTVKEHEHVQKKIFRMLEELMMTGTTTKKAVISSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV1</accession>
    <name>K0INV1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60014">
        <property type="protein sequence ID" value="AFU60014"/>
        <property type="gene ID" value="Ngar_c30980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30980"/>
    <dbReference type="HOGENOM" id="CLU_3057253_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3098-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6006" checksum="7C8877E7CF948F95" modified="2012-11-28" version="1">MTAEPKPLVKCQLCFEDIDPALREHHLKEVHKISAAAIGDSKPLTHWFKPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP29</accession>
    <name>K0IP29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PUA domain profile</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c34910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34910"/>
    <dbReference type="EnsemblBacteria" id="AFU60404">
        <property type="protein sequence ID" value="AFU60404"/>
        <property type="gene ID" value="Ngar_c34910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34910"/>
    <dbReference type="HOGENOM" id="CLU_116577_2_0_2"/>
    <dbReference type="OMA" id="QLIAYIY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3492-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TGT_C2" evidence="3">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20519" checksum="7FD6C59F50DDDAF8" modified="2012-11-28" version="1">MPSLDYIVVGCNCHYIYVAYKTATFYLNPLPIDAREKVCRHIDALFGVGVSEALPADVSFEFSKRTGRIKNFSIGGRLAGTLRTDGGIALTIAGAQHFFDNSRRQFRESCVAPVQEAVPFVSGGRSLFCRHVEWCGSNVQVGSDVAVVDDRSRVIAVGVAILPSDLMKWYSRGVAVKIREGLKGRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP32</accession>
    <name>K0IP32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60419">
        <property type="protein sequence ID" value="AFU60419"/>
        <property type="gene ID" value="Ngar_c35060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35060"/>
    <dbReference type="HOGENOM" id="CLU_2839489_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3507-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7519" checksum="A7D9CC8E8FE0359B" modified="2012-11-28" version="1">MRGGSFWLEQSQAQIFFYIFLANWIASIFAGYVYMNMINLIVPRCTSDSLLIDLCYTNSTPLQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP45</accession>
    <name>K0IP45_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA methylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c35710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="55344">
        <property type="entry name" value="M.Nga92ORF35710P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60484">
        <property type="protein sequence ID" value="AFU60484"/>
        <property type="gene ID" value="Ngar_c35710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3578"/>
    <dbReference type="HOGENOM" id="CLU_722831_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3572-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044832">
        <property type="entry name" value="NRP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034">
        <property type="entry name" value="PTHR46034"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00767">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DCD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="382" mass="43259" checksum="F43BB3BE30254BCA" modified="2012-11-28" version="1">MKATCGHIFACTSKSERECFDRMLFATSRVYGESVLKIKKGDLLFLLNLDTDTLYGTFRAKSAGAKDLVPEAWNGKYPYQVQVSRNGAVHSLAGAKKVLSGMGLSWRDTLDGEQARFLSQYIENPDGKAIIKIAKKDVIEDKPRLESTTLWDYPRQSYGKTQKGNNKYAGVTPAFVIYNMVKRYTEPGDLVLDPMAGSGTTIDVCKEEGRRCIAYDISPTRPDIKQNDARKIPLADESVDMIFIDSPYGDNIDYNDKPGNIGKLSAETDEFYKALDMVMAECHRVLKPGKVLGWLIGDQWVKKKFTPVGFNVYEGLSKYFDTVDIVCVARRSQTSNTGLWHSRALRFNFYLRGFKYLFIMRKPAAGEQALKRKISWTQYPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I722</accession>
    <name>K0I722_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase Nep1</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">16S rRNA (pseudouridine-N1-)-methyltransferase Nep1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nep1</name>
        <name evidence="6" type="ordered locus">Ngar_c01160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11633"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01160"/>
    <dbReference type="EnsemblBacteria" id="AFU57066">
        <property type="protein sequence ID" value="AFU57066"/>
        <property type="gene ID" value="Ngar_c01160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01160"/>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_2"/>
    <dbReference type="OMA" id="VYVHTRN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00554">
        <property type="entry name" value="NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023503">
        <property type="entry name" value="Ribosome_NEP1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="202"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes Arg-xx" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="242" mass="26915" checksum="72B0256B32C35739" modified="2012-11-28" version="1">MTTLIIAEAALETVPCEIINHPAVRNHARRLGLKPSETLLDRSYHHAAMSKLQDNGRRGRPDIVHFALMEALGTPLFLRGMLKVYVHTVNDRLITIADNLRIPKSYFRFEGLMVSLFRDKVIKSDEGRVLMEISDGTLADLVNAIRPSRVIGLSRTGIQGTAEKAVAENLADDGCCAFVVGGFPRGHFSESTTRLLNLTYSISDIGLEAHVVIARVLYECEKFLLEKGIHHEGDEKRRQVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7U3</accession>
    <name>K0I7U3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative CRISPR-associated protein, Cas6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cas6</name>
        <name evidence="6" type="ordered locus">Ngar_c03880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03880"/>
    <dbReference type="EnsemblBacteria" id="AFU57336">
        <property type="protein sequence ID" value="AFU57336"/>
        <property type="gene ID" value="Ngar_c03880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03880"/>
    <dbReference type="HOGENOM" id="CLU_1067997_0_0_2"/>
    <dbReference type="OMA" id="MERTAGF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="5">
        <location>
            <begin position="133"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="29579" checksum="CF93AACE7ED2BC17" modified="2012-11-28" version="1">MVTELEVKTFAEKSVKMPLFTGYVARGLALHILNRVDPALSQDLHEPNAIKPYSVTPLYFRSTKKLADGYQLDASTPCIFKIRFLDDRIAKSAIDYFSSNESLMIYDTAFKVSSLTIKSEDFTKVQDSKLFRLYFETPTHLAKIGSKFDQVFPEPLSVFPNLMRAWDSCMPEKFGKKVFEKYKEWMEKNVTVSAYDLHTLTVTAGKTLKIGFTGWCAYRIDDSSENPQFRLITNKLAKFAEYSNVGMERTAGFGVVKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I802</accession>
    <name>K0I802_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57401">
        <property type="protein sequence ID" value="AFU57401"/>
        <property type="gene ID" value="Ngar_c04550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04550"/>
    <dbReference type="HOGENOM" id="CLU_3057243_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-454-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6206" checksum="5409AF399C6605FA" modified="2012-11-28" version="1">MRIDVGQLFSRVSEIEYKKLFNNAERELSPFVSQDSGRISFPLKSRFVLARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8C0</accession>
    <name>K0I8C0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57521">
        <property type="protein sequence ID" value="AFU57521"/>
        <property type="gene ID" value="Ngar_c05780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05780"/>
    <dbReference type="HOGENOM" id="CLU_2406447_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-576-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10260" checksum="172A7F9898761FB5" modified="2012-11-28" version="1">MAKFDGIKGQELLDFEKTKDELTLIFKDNRYLFIKVNSGDLVVDLAACNTAKGQELQSVEEGSGEITLIFKDDHKLPVKVQSGQMQVDSIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8M9</accession>
    <name>K0I8M9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetylglutamate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06930"/>
    <dbReference type="EnsemblBacteria" id="AFU57636">
        <property type="protein sequence ID" value="AFU57636"/>
        <property type="gene ID" value="Ngar_c06930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.669"/>
    <dbReference type="HOGENOM" id="CLU_092699_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-691-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="15001" checksum="86E90B71D9C3744A" modified="2012-11-28" version="1">MRQFIVDSAYDLPSLDQTSERLLDNQEDIGNAVKPYYGEKAGDQLTKLLKEHILIAADLVNAAKAGDNSAVADADQRWSDNADDIAAFLAKANPNWDEDELSHMLHDHLKVTKDEAVARLQSDYEADIEAFDKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9T1</accession>
    <name>K0I9T1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c11400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11400"/>
    <dbReference type="EnsemblBacteria" id="AFU58081">
        <property type="protein sequence ID" value="AFU58081"/>
        <property type="gene ID" value="Ngar_c11400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11400"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_2"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1138-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="18379" checksum="2C0906E120401905" modified="2012-11-28" version="1">MEKEEAEKQAGLAEGDVAPDFAMRDKDGKTIKLSELRGKKSVVVYFYPKDFTPGCTMEATEFSRDYKKFKDAGIEIVGVSPDDEESHQKFRDKMGMPYPLVADTENEVSKKYGVYGLKSFMGREYMGVNRSTFLVDKSGKIVKIYRKVKPAGHSQEVLQALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAU7</accession>
    <name>K0IAU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58456">
        <property type="protein sequence ID" value="AFU58456"/>
        <property type="gene ID" value="Ngar_c15220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15220"/>
    <dbReference type="HOGENOM" id="CLU_2165346_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1520-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="110" mass="10876" checksum="F84747C8EC7C7251" modified="2012-11-28" version="1">MGFLITKANFTFRTMIPTTRLVMLATVVATTLVPAAAAAQTTINQSNSNTNNQAATASASVGGGGTGNTNTAVAAISQDAGACQQNVAAVNFSTASAQIGGGQNSFTDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB82</accession>
    <name>K0IB82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16430"/>
    <dbReference type="EnsemblBacteria" id="AFU58576">
        <property type="protein sequence ID" value="AFU58576"/>
        <property type="gene ID" value="Ngar_c16430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16430"/>
    <dbReference type="HOGENOM" id="CLU_1357953_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1641-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="210" mass="23205" checksum="2A80EEA35D1CB71F" modified="2012-11-28" version="1">MKQDRVELSQVKLFMFNASSFPLDPSIENFLKSKGAISLDFGATAYINSEAMPTILSELVERSKIDVSSNAELVAQLKAEISRYGAERQKLIEDNARLVTRGRSYSAEIAGLKEQIASATLLIDSLRAENARLQAALKNAPSAQKTQTVQSDDKLKQSYEKLQKEFQALRAQNVEALTSLKILEDENEELTRELDLLKSQSKNAAAPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBK0</accession>
    <name>K0IBK0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="7">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">purC</name>
        <name evidence="9" type="ordered locus">Ngar_c17230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17230"/>
    <dbReference type="EnsemblBacteria" id="AFU58656">
        <property type="protein sequence ID" value="AFU58656"/>
        <property type="gene ID" value="Ngar_c17230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1697"/>
    <dbReference type="HOGENOM" id="CLU_045637_0_1_2"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="31977" checksum="0D8FC2CEDACF333A" modified="2012-11-28" version="1">MRLLRKGKVKDIYELDNGNILFHFSDRVSAFDVNMATPIPRKGEVLCRFGQFWFDTLQTPHHMVRIVEKDKMEVKKLKMVPVECVVRGYFYGSFVDRYKGHLGKGLPLDFKPILAGKLPRPIFDPTTKSEEHDTPITRQQAIFSGILSEKDFDYLEKTSISLYEKMSKIVERAGFIIADVKFEFGRNEQGDIVLGDSLGPDEYRLWLKTDHQPGKVQESYDKQLLRDWLAKIGFKDKVDSLAKEGKKPESPEVAPEVANELSRRYILAYERISGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBL6</accession>
    <name>K0IBL6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rps19p</name>
        <name evidence="7" type="ordered locus">Ngar_c17330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17330"/>
    <dbReference type="EnsemblBacteria" id="AFU58666">
        <property type="protein sequence ID" value="AFU58666"/>
        <property type="gene ID" value="Ngar_c17330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1707"/>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_2"/>
    <dbReference type="OMA" id="VIRTHCR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="15540" checksum="A30AA2AD085BC2EF" modified="2012-11-28" version="1">MVREFKFKGYTHEQLQSLSIENLLPLLNSRQRRSLDKRVSTYMNDDKRKLREKVKLAREGKMKGNIRTHARDMIILPDMVGLTIHVHNGKEFAQVNIKPEMIGHYLGEYAITNKRVQHGAPGVGASRSSLYVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC10</accession>
    <name>K0IC10_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP cyclohydrolase I</fullName>
            <shortName evidence="3">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">folE</name>
        <name evidence="5" type="ordered locus">Ngar_c01400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01400"/>
    <dbReference type="EnsemblBacteria" id="AFU57090">
        <property type="protein sequence ID" value="AFU57090"/>
        <property type="gene ID" value="Ngar_c01400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01400"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.140"/>
    <dbReference type="HOGENOM" id="CLU_049768_3_3_2"/>
    <dbReference type="OMA" id="CEHMCMS"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="4">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="22274" checksum="73F53B33AC67FCBE" modified="2012-11-28" version="1">MTTTAEKTAAINKRKIAKLVRELLIELGENPDREGLTGTPSRIADMYEEIFSGYRMDAELDVSFSEETDAVVAKDIQFYSMCEHHMLPFFGKIHVAYVPSGKVFGVSKLVRLVEKYSRRLQIQERLTKQIADELVRMGVKGALVIAEGEHLCMKMRGVRNDSSITTIAHRGIMEQKEVREHVLALIYNPKSEMTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICB2</accession>
    <name>K0ICB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57175">
        <property type="protein sequence ID" value="AFU57175"/>
        <property type="gene ID" value="Ngar_c02270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02270"/>
    <dbReference type="HOGENOM" id="CLU_049301_16_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-227-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="159" mass="17817" checksum="5E863032DBCA7C9E" modified="2012-11-28" version="1">MALSVVSKILVPIDGSESSMRAANAAIELARRYNEESRPVEVIALHVIDINPKFHLFTKYGFHYSEYERKAKETAQKGTAEWFPKIKEKADHHNLRFRSEVTDSSSASVVGEIVKFAEREKVDLIVLGTRGQSEFERLLIGSVTSGVTVYAQCSVMIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICD1</accession>
    <name>K0ICD1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family UPF0434/Trm112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21050"/>
    <dbReference type="EnsemblBacteria" id="AFU59036">
        <property type="protein sequence ID" value="AFU59036"/>
        <property type="gene ID" value="Ngar_c21050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21050"/>
    <dbReference type="HOGENOM" id="CLU_155659_4_3_2"/>
    <dbReference type="OMA" id="ACPYDKT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2103-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10748" checksum="A7A7564274C15845" modified="2012-11-28" version="1">MKKSMLDILACPIDKHYPLELFEIVSEGQTVKEGVLFCTKCSRYYPIIDEIPVMLPDELREKDKNRDLDFLKKWQSKIPDKVIKQGNPWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICU4</accession>
    <name>K0ICU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative small-conductance mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57485">
        <property type="protein sequence ID" value="AFU57485"/>
        <property type="gene ID" value="Ngar_c05420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05420"/>
    <dbReference type="HOGENOM" id="CLU_1709190_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-540-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="153" mass="17022" checksum="3712F57F793353BD" modified="2012-11-28" version="1">MTPEPKFENIDRSANVQSQGEGTVSVVTPRERPIIIGDRKNYRYIRKKRARILKEIADIKADYAGRPPDAPVMLTIGQVPLKLALKIKEYQLKVLGMCTGHGPGTLKRLLDIQQSLLCDNCRKSSLYGGDLQCTADLWPFLAVNILMGALAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID21</accession>
    <name>K0ID21_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureF</name>
        <name evidence="4" type="ordered locus">Ngar_c06170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06170"/>
    <dbReference type="EnsemblBacteria" id="AFU57560">
        <property type="protein sequence ID" value="AFU57560"/>
        <property type="gene ID" value="Ngar_c06170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06170"/>
    <dbReference type="HOGENOM" id="CLU_049215_4_0_2"/>
    <dbReference type="OMA" id="HVRLFMN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="248" mass="27820" checksum="009E0430689AB4F8" modified="2012-11-28" version="1">MNLMREWMSMSTEHEHTMTDIADIGMMQLADSFFPTGMYTTSSGLEAIFYSERKKMSPDELRDLVKVFLEHQIGPADCTALGNAYEHASKGNLDMLLEVDNTIHAMKLVKEIREASSRSGTQMLRCIHSFSQTNKLLGGYLAALKEGKGHGTYPVALAIAANVFSIPKRKAGIMMLYSFSVSIIGAALRLGMLQHFDGQRIIDELKPIISKTVESYIDRSIEGIWQFAPQLDIIQMTHERMSSKMFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID46</accession>
    <name>K0ID46_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl2</name>
        <name evidence="7" type="synonym">rpl2p</name>
        <name evidence="7" type="ordered locus">Ngar_c06420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06420"/>
    <dbReference type="EnsemblBacteria" id="AFU57585">
        <property type="protein sequence ID" value="AFU57585"/>
        <property type="gene ID" value="Ngar_c06420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.620"/>
    <dbReference type="HOGENOM" id="CLU_036235_0_1_2"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_L2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_L2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="246" mass="26226" checksum="574632317A6A6BE5" modified="2012-11-28" version="1">MGKRTLVRRRGRGGKQFRAVIVGKIAPAKYPNFKLEDHHIGKVVDIVHERGRDAPLAKIRFDDGRYSYVPAPDGTIVGSTIEAGTGATARAGNIMSLESIPDGTIVCNIEKNAGDGGKLIKSAGSSAVVFAHGTEGVTIKFPSGKFLTLNQKCRAMIGAIAGAGRKEKPFLKAGLRAKYMQAHGRLYPTVRGIAQAAVYHPHGGGRHQHIGRQSSVGRTTPPGRKVGNIAPRKTGRGRIKDPNQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID49</accession>
    <name>K0ID49_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ecx2</name>
        <name evidence="5" type="synonym">rrp41</name>
        <name evidence="8" type="ordered locus">Ngar_c23860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23860"/>
    <dbReference type="EnsemblBacteria" id="AFU59311">
        <property type="protein sequence ID" value="AFU59311"/>
        <property type="gene ID" value="Ngar_c23860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23860"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2358"/>
    <dbReference type="HOGENOM" id="CLU_063514_0_0_2"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="6">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="7">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="247" mass="27298" checksum="B37B740BB12DB1CA" modified="2012-11-28" version="1">MTQTRNLIDENGKRTDGRGIDELREVKITVGTVKNADGSAFIEFGKNKILAAVYGPREVHPKHMAQSDRCVLRCRYHMSPFSTDTRKNPAPSRREVEISKVMREALEPALMLEDYPRAAIDVFVEVLQSDGGSRCAGITAAAVALADAGINMRDLVAACAAGKVDDKIVLDINDTEDKEGSADMPVAYMPRLEQITLLQLDGKLTPDQFNECLDKAIGGCKMVYEIQKQALMQKYFGNETELKEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDQ2</accession>
    <name>K0IDQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57840">
        <property type="protein sequence ID" value="AFU57840"/>
        <property type="gene ID" value="Ngar_c08980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08980"/>
    <dbReference type="HOGENOM" id="CLU_027402_15_4_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-896-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11960" checksum="492BA0E76F3BEAA1" modified="2012-11-28" version="1">MNTNVLERASPTTSAEEKYGVSRKTCYKWKNRYLARGIDGLKDLSRRPHNTTEQKVTPELEQIIPGLLRLDSRFGTARIKFRLKRLGASLSSRTVYRVLKRHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDR9</accession>
    <name>K0IDR9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tfe</name>
        <name evidence="6" type="ordered locus">Ngar_c00080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00080"/>
    <dbReference type="EnsemblBacteria" id="AFU56958">
        <property type="protein sequence ID" value="AFU56958"/>
        <property type="gene ID" value="Ngar_c00080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00080"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.9"/>
    <dbReference type="HOGENOM" id="CLU_100097_0_0_2"/>
    <dbReference type="OMA" id="DSGWLTY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU56958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="20023" checksum="AA4641F6517FB514" modified="2012-11-28" version="1">MRSIEYEDSFVKIAGLIGGEEYVKVARALLNTEDVTDEEIASATGLKINIVRKVLYDMFGKALITGIRVKDEKKGWFVYRWRAKQDQVDNFIENQKKKILDRLHKRLEYEESTEFYHCGNRDCPRVKFDAAVELFFKCPNCKGPLNMVDNTKVKEALRYKIDQITTDISSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDT3</accession>
    <name>K0IDT3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59546">
        <property type="protein sequence ID" value="AFU59546"/>
        <property type="gene ID" value="Ngar_c26240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26240"/>
    <dbReference type="HOGENOM" id="CLU_3094232_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2624-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5860" checksum="1B4F9E8A172BC49B" modified="2012-11-28" version="1">MMFAGAEELEEHNIAAHNFAEQEESSLLRKACEEEKARKRSRGPYRKAHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEL0</accession>
    <name>K0IEL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02600"/>
    <dbReference type="EnsemblBacteria" id="AFU57208">
        <property type="protein sequence ID" value="AFU57208"/>
        <property type="gene ID" value="Ngar_c02600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02600"/>
    <dbReference type="HOGENOM" id="CLU_3021086_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-260-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6076" checksum="4BC70774E87866EA" modified="2012-11-28" version="1">MSSGSECVGKSITRIDLNSWERLNVMPMPDVHQSGSQDGLLGMAFDPNFNNTNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEW6</accession>
    <name>K0IEW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57338">
        <property type="protein sequence ID" value="AFU57338"/>
        <property type="gene ID" value="Ngar_c03900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03900"/>
    <dbReference type="HOGENOM" id="CLU_1352150_0_0_2"/>
    <dbReference type="OMA" id="SAARMEY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-390-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="24277" checksum="AB858EB843E4369F" modified="2012-11-28" version="1">MEGSPEQEQDYFGGLDINPEFIEENKKMITNLGKLRQKSKPHNKSEIAKRRKEVYRLHFESGLPVAAIADQMKVDKNTIRNDIFVLYREIGKDREGINFEDNYAKQVDRLEAQRARLLSYLKKAGEIDQQLAIERMVADIDLKLLASAARMEYNRTAFWDAIRKTINKWAAEEKIDDLRVTQLFELVRISEKTRKNIDKITRETWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF94</accession>
    <name>K0IF94_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c05500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57493">
        <property type="protein sequence ID" value="AFU57493"/>
        <property type="gene ID" value="Ngar_c05500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05500"/>
    <dbReference type="HOGENOM" id="CLU_2519870_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-548-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9340" checksum="20E7112C8FAA136E" modified="2012-11-28" version="1">MAIERCDKCGKSFMSKSEVERHKMWEHPVPVSPFEERPAAAVNNNNGINPDEVHKLTSDVMAGTRSKGSSAIGSGQRRRVPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA4</accession>
    <name>K0IFA4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57508">
        <property type="protein sequence ID" value="AFU57508"/>
        <property type="gene ID" value="Ngar_c05650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05650"/>
    <dbReference type="HOGENOM" id="CLU_107441_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-563-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="20170" checksum="D76810F082811390" modified="2012-11-28" version="1">MLFKKSNNASIKERANAALASLQRNAYAMGMLRSRLESRINFTLNEKGSTESCQELTRVLELVKNGEMILHEMSEKIESARFLEEFVMIMDSAASSVSEIKDDIEQMMPAAEAALEEMHDAISKVSSGLPADLRQEIEPAILAEAVAAIAAGNASAAVIEAKEEKEEKTAAVPEQEEEEPESVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFD2</accession>
    <name>K0IFD2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57538">
        <property type="protein sequence ID" value="AFU57538"/>
        <property type="gene ID" value="Ngar_c05950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05950"/>
    <dbReference type="HOGENOM" id="CLU_2597858_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-593-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8797" checksum="62604B0527A0E4ED" modified="2012-11-28" version="1">MLAAAKNHCNPSKREGATLQYGNGYRDICSDDMAADRFRTDKRLVRVIFVDETLLQIETVVTTTGYGFFAYEPAIDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFH5</accession>
    <name>K0IFH5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">Ngar_c16320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16320"/>
    <dbReference type="EnsemblBacteria" id="AFU58565">
        <property type="protein sequence ID" value="AFU58565"/>
        <property type="gene ID" value="Ngar_c16320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1604"/>
    <dbReference type="HOGENOM" id="CLU_034547_0_0_2"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="364" mass="38471" checksum="F3E823066EE4933E" modified="2012-11-28" version="1">MGGSIIGERFVAMSFGESHGRCVGIVVDGCPAGLPLDESDIQGLLDLRKPGQSVVMTQRKEEDRVEIISGIFNGNTTGAPICMLIWNKDSDSRPYEMIKNIPRPGHADYPAMVKYGGFADYRGGGRFSGRLTATLVMAGAVAGKLLKRTLGIETVAYTTEIGTVKAGNITPANIATRYSNDVRCPDPAAAEKMREAILQARKDGDSLGGVIECITSSLPVGLGEPIFASLESDLSKALFSIPAVKAVEFGSGFAGSKRRGSENNDVYMIRDGKVVTKTNNAGGILGGLSNGMPLVIRVGFKPAASIAKTQETLDIAKNSQTYLEVPGRHDPCVVPRAPPVVECVVSMVLADHAIRAGLIPPVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFM0</accession>
    <name>K0IFM0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57628">
        <property type="protein sequence ID" value="AFU57628"/>
        <property type="gene ID" value="Ngar_c06850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06850"/>
    <dbReference type="HOGENOM" id="CLU_1682751_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-683-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="17448" checksum="E2A0E75AFA3EA97D" modified="2012-11-28" version="1">MPAEKGKWKMSEQKKETILVTGTSGGIGYPVAKRLAEEQHQQPSYNVVGFDRKAPSYPSPSAECLHVDLTKEKSLRRGLQAIRDLHGDRIASVIHLAAYDDFSGAASPLYDKVTVQGTRQLLQLLQEEDFNVEQFIFCPGSRSLYTMSSYQRRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFR3</accession>
    <name>K0IFR3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60201">
        <property type="protein sequence ID" value="AFU60201"/>
        <property type="gene ID" value="Ngar_c32860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32860"/>
    <dbReference type="HOGENOM" id="CLU_961774_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3286-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="289" mass="31252" checksum="35388CE93C78BB7A" modified="2012-11-28" version="1">MFVAVPTSHEAGRRLKGSSSITHDGGALDDERREEKEEKSSSPSANKQAQEGTSRGLDTSDIWRILSNTLLIALGLVLIGVQASWALLLTFIVVYLQSLNISLEGAGVIASMALISAIISAPLIGGFYDRAVKNARKILVICGAGISISFAAMSSQIMPVIIISVISIGFFSGGAFTLAYAIARRMRIIISSTTGSDVHEQKDRNDDNSPELEPRRGEEEKHDKSKDKMPDYSALNIAWINGLSLLGILWMPLVFSFTVKSWAGYPGAWLLSAILVALFVFIPLQKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFS4</accession>
    <name>K0IFS4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60226">
        <property type="protein sequence ID" value="AFU60226"/>
        <property type="gene ID" value="Ngar_c33110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33110"/>
    <dbReference type="HOGENOM" id="CLU_2191110_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3311-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12970" checksum="78F26E6E51AE7620" modified="2012-11-28" version="1">MKGSILFSSYKDEIQPLLSRQEYEAFLFKAAIRMGTRKEFLEKLGGINYAFAEYGKINQYTIPLDKEVKTLLLISEDKLSQNSDDGRHHNNNNTSSSSIDRIMKILRKYGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFX9</accession>
    <name>K0IFX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase</fullName>
            <ecNumber evidence="2">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thrC1</name>
        <name evidence="2" type="ordered locus">Ngar_c17620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17620"/>
    <dbReference type="EnsemblBacteria" id="AFU58695">
        <property type="protein sequence ID" value="AFU58695"/>
        <property type="gene ID" value="Ngar_c17620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1737"/>
    <dbReference type="HOGENOM" id="CLU_028142_5_0_2"/>
    <dbReference type="OMA" id="EGASPFH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="113"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="446" mass="49277" checksum="4CE0CB8BB6B14D97" modified="2012-11-28" version="1">MDAYAIKKCINPACGLTYEINNDIYRCSCGSLLDIKYNKKPSRDLVETFYQRRNHGGNIYNESGVWRFRDLINFAGIDTENFEECARVLVSLDGSEGRLSKPYNMSKAADYAEMNHDSFLLQPEGYNPSGSFKDNGMSTAVTHAKMLGVKRIICASTGNTSASAAMYAANENMECDVYIPKGEIAPGKLGQAFQFGAQVIQVQGNFDDALAASLKNAKETGGYTVNSVNPFRLEGQKTIVYRVLEHLNWNPPDWIVYPGGALGNTSSCGKCLIELYEWGWIKKIPRMAIVNAEGANTFYELYNGLFEGKRLTWNDGRPDLAMVDRYYEHLDKKGIRPKTHATAIQIGKPANIVKALRALDFTNGIVVQVSDKEMSDGMSIVGLNGFDCEMASGAVPAGVRKLRREGLIKRDDVVVGILTGRQKDPGLAVEYHTNPNNMFAKPPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG58</accession>
    <name>K0IG58_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57798">
        <property type="protein sequence ID" value="AFU57798"/>
        <property type="gene ID" value="Ngar_c08560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.818"/>
    <dbReference type="HOGENOM" id="CLU_020671_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-854-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="244"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="678" mass="76307" checksum="EF9A6A636DBBBB01" modified="2012-11-28" version="1">MIKAEILRFADLKAGQTTPVGLGIAKSLRLGQHLHMVLVVTRPNNFSKMAFPTDELLAYDVEITDDVGKTMTLKDLGLIGGKNSIVYQRETLPTFFLRGKDAPLNFLHGSCRKLHGKGEDCLAAADDLIESSFADLKRRPNVLFLTGDQIYADDVAGPLSHYLTQLGIRLLGWEEKINGVGKKLTEIRIGERQSLVKKYAGFTSPNAGNHLLSFGEFAAMYLLAWNAENWPAKFPDISTVSKEHQNKYREQIRQLEHTRKDLPAVRRVLANIPTYMIFDDHEITDDWNITREWQENVKGSKCGKQVVANGLAAYWAFQGWGNDPALYSSDFIGKIVEFLGKNGEPTEAERDAFEDLLWNFDNWTFRAPITPLTVVMDCRTQRQYDSHDGPPQLLSSKGFHSILQAAKEANYQKGDPIIIVLPTPVFGFLLLEALQKAAAKITGVYKLDLETWFANESGLVNFLSFLMHSLGPRHCIFLSGDVHYGFTISAAFALLQNGHEYLHMSITQLNSSALKTTSLVKIAFISEIMGRIRQLFPWRQVVRIGWVNGGLSNNRFSSKSLRIKGKPTRHLYVRPRKSPELSKQRSPDWIEARTIVKASGSIIPPLLISDNNIGLVSIEDSKVIQRFLVRKEITKDTRIHQTVVEMNQGRNELDELISAKMREFATEHSTVSSHESAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG70</accession>
    <name>K0IG70_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18520"/>
    <dbReference type="EnsemblBacteria" id="AFU58785">
        <property type="protein sequence ID" value="AFU58785"/>
        <property type="gene ID" value="Ngar_c18520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18520"/>
    <dbReference type="HOGENOM" id="CLU_3387501_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1850-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="32" mass="3953" checksum="20C929F33CC2647B" modified="2012-11-28" version="1">MYLKEIEFRFNYRNENLHPILTKMVVRTAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGB2</accession>
    <name>K0IGB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cysS1</name>
        <name evidence="5" type="ordered locus">Ngar_c19030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19030"/>
    <dbReference type="EnsemblBacteria" id="AFU58835">
        <property type="protein sequence ID" value="AFU58835"/>
        <property type="gene ID" value="Ngar_c19030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1887"/>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OMA" id="GWHAECA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="4">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="374" mass="41948" checksum="CAF6D38745F65CD4" modified="2012-11-28" version="1">MQQLYDTLSGRKERFVVKGNQVRMLLCGPTVYDYAHIGHARMLLFYDLMARYFRSKKIGVSVIVNITDIDQKVFSKARAAATGPAELASKFIDELLRDLSSLGIDGFMLARVSDHVTTARQLVAGLLQSGKAYSAGGNVYLDTAATLSLGMMAKMTKKDLDDCRLDISPAKKSPSDILMWNASESFDVSFRDDILGSGIPWWHMQDASVAMANYGGLYDIHGGASELVYPHHESHLAQLQALTLRDRPVRFWTHVGLVRTKGKKMSKSLGNTVAVRDLLKRYSANALRLYFYSRHYRDDFDFSESDLGRFQRIDDMIASAMNSRRLDGRKMAERFFDRIEDDFDTPGAISVLIEGAKSRSADLGTMVSVFGLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN7</accession>
    <name>K0IGN7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56972">
        <property type="protein sequence ID" value="AFU56972"/>
        <property type="gene ID" value="Ngar_c00220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00220"/>
    <dbReference type="HOGENOM" id="CLU_1346448_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-22-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="203" mass="23382" checksum="D69546D4A7A79103" modified="2012-11-28" version="1">MVTDEDHSRHVSKREHIAKHLGARKIEFIATTIIGVVFAVSFAHLEYYYIKDPALQISNGEVLVTDSNFDRSRETEPIIGNMYQYHLFPMLFIFVLISFAALWDDMSFKLLGRHKRIKAMFIGFANLITAIVVEDFAWFVNRWAVPLESDPKGGLLMQWTDWTSMHMGAIDFGSFVVPTWYLIAVALAALAYYGGFRKHDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGV5</accession>
    <name>K0IGV5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59080">
        <property type="protein sequence ID" value="AFU59080"/>
        <property type="gene ID" value="Ngar_c21500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21500"/>
    <dbReference type="HOGENOM" id="CLU_1709192_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2148-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="153" mass="17401" checksum="0CDB8F36D2DE0961" modified="2012-11-28" version="1">MLYLKVKESLSKDHPVIYAAEADANSVIRKMVNAGIEAENFIEKGILKIIDAQTAKQLKAQINLESMDPWYQTICKTIKQAKAKNRLLIICRTEDFEQAKLLKFEEMVDRGIASLPIELICCYPTKWLTKLDLSSIIGILNAHTLYTERSLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX6</accession>
    <name>K0IGX6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gds1</name>
        <name evidence="3" type="ordered locus">Ngar_c11620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11620"/>
    <dbReference type="EnsemblBacteria" id="AFU58103">
        <property type="protein sequence ID" value="AFU58103"/>
        <property type="gene ID" value="Ngar_c11620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1102"/>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_2"/>
    <dbReference type="OMA" id="WLIAESI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="31142" checksum="68E465C8C36747C7" modified="2012-11-28" version="1">MIEQFADHIARIEDALKRELDLYSWSEFHAPLRYACDGGKRIRPLILVLSAECINSKKPGADAYLAASAIELLHTESIIHDDIIDEENQRRGKPSFHVKYGYNSSILTADFVLGIILNIGSKLKDARIVNELSNAATRMSEGEMMEIRLNKSPDINEDDYIKVLEYKTASLFEASAKVGAMIAGGSEDQIHAMSSFGNLLGIAYQIHDDLIDWNNENRLFNMLVRKNGKSKELVDQMDKLYQSYAAKAKNELRKIPAENEAKRHLEHLTDLASVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGY5</accession>
    <name>K0IGY5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c01320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01320"/>
    <dbReference type="EnsemblBacteria" id="AFU57082">
        <property type="protein sequence ID" value="AFU57082"/>
        <property type="gene ID" value="Ngar_c01320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01320"/>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="OMA" id="TRILMSM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-132-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="460" mass="48705" checksum="A93541C5C02E85BB" modified="2012-11-28" version="1">MLKAGADKEPGLKRNVNLFQAVMYGVGLILGAGIYVLIGDVAGIAGNAMWMSFIVAAVIAAFTGLSYAELSSMFPKSAAEYVFVKKAFRNNLGAFIAGWLITFVAIVSAAAVAVGFSWYLSSFFQQLDPVLSAVALVLVLSLVNFIGIRESVWMNTMFTLIELAGLALIVTAAVLLGSFSGVDYYATPPATSSPSSSFSLSAGAILSAAGLAFFAYFGFENLANIAEEAENASRTIPRALVISVAVTTGVYIIVAASAITLLGWERLSSSDAPLALAAEQTFGRAGVVTLSTIALFATANTVLMMLIAGSRIMFGMAREHALPSTLGRIHPTTRTPWIAVVLTMLLAIAVVVLSQGSISVIANISVFAIFIVYALVNLALIWLRYKQPELKRPFRSPVKIGWFPVLAGLGFVTSLSMLTQFDSTTMLAGIVAVAAGLASYAALKKYGKRQFQAQSKHESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH22</accession>
    <name>K0IH22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22300"/>
    <dbReference type="EnsemblBacteria" id="AFU59160">
        <property type="protein sequence ID" value="AFU59160"/>
        <property type="gene ID" value="Ngar_c22300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2210"/>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="OMA" id="MKSHELF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2228-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="275" mass="31930" checksum="F1E1B64A13220F60" modified="2012-11-28" version="1">MPPAEEDVLAPYVNTKDTFIELASEQRLAIMFRLNEKRAKISQLSKDLGITMQEVHRNVKRLQDAGLIEKDPEGVFSLTTFGNTIIKQIPTLNYLAKHKDYFSEHVLGELPIKFIMRLGALDKCEFVKGVVAILERWKDIYRQADEYIYEIVPQVPIDLIEPAVTRVKEKGVKYSYIFPKDVIIPKGRKELLKKLGHNELLNKGAIERRMVESVQVAVILNEKQAAVLFPTQKGETDMNIIFYSSDPVFHEWCLDYFRYRWYGSEIFDESKLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN2</accession>
    <name>K0IHN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14980"/>
    <dbReference type="EnsemblBacteria" id="AFU58433">
        <property type="protein sequence ID" value="AFU58433"/>
        <property type="gene ID" value="Ngar_c14980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14980"/>
    <dbReference type="HOGENOM" id="CLU_408629_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1496-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="277"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="672" mass="75854" checksum="F5A28500A7D63D7D" modified="2012-11-28" version="1">MSYFALRYYLAAIFFSFIFIGVIDSITTFEEWILHTAMQFLRNAVQLYATTIGDPVPFVLQPLQTESLLDRDGLHVETDTGTITFDLPIIAQMLFLVFFPTIAFTARIDMKMRLRLLAFGMICFLLFIAVQLVIIASSLYIEPLQSPFAFRITSIIVTILTGGLAIEVALFSTVTIPTPTKVKPFIKRRYFREYANLAIILVSSSVILYLLIYFLGLDAYSGEPMTLDYIYLGFWLNVPVVITFSYFIANLMYEIKRPVHAYKAPKNEKDTPWPSVSFLISAYNEERLIGRCIESIDRAAAKYAGKVDIVVVNDGSRDNTERIISESLRKLKFCSGVFYTIPNSGKGFALAYGLQRTSGEIIFRTDADSALDENALAPMLSHFKNPEVGSVSCWIMPLEGKGAWLKAQNVLCAYYFYTKRAQEMVDGIITQPGPASAYRRDILIKAGGWVDNIFGEDGEITNRVARLGYRGVFEGNALIYSELPETLVGFMQQRARWSVAFFHSRGRNLRLAREVGNSRWPVFLWNLMSHGISLGRGLLWPYMAVSILMGTVGLSTPELITYGVIITKLLGIQAIIYAVAIILYAYRLNKAGKTRYMLYFPLVRFLVIILNFIVKPQALEVLLSWSVRWKEYTTESFRDLRKVVHTSIDPLYPSGEQVAHSKKADDATAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS1</accession>
    <name>K0IHS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubiquinone/menaquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ubiE1</name>
        <name evidence="4" type="ordered locus">Ngar_c04400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04400"/>
    <dbReference type="EnsemblBacteria" id="AFU57387">
        <property type="protein sequence ID" value="AFU57387"/>
        <property type="gene ID" value="Ngar_c04400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04400"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.422"/>
    <dbReference type="HOGENOM" id="CLU_037990_12_0_2"/>
    <dbReference type="OMA" id="FEYMPFR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="232" mass="25540" checksum="6E2DA7ED8FA8C9A0" modified="2012-11-28" version="1">MSGLGSRYWGEVIEVLRYIIPVYDKVNRVISLGKDEEYRLRGIRGRVSAGNIVLDAGSGYGNMSRVALAEAGGDAKIVMYDPIPEMLANVKNYLPDSQAALSSGVFEYMPFRDGTFDAVLCGYSLRDAIQLPQAIAEMHRVLKAGGRLVIVDLGKPDSPVARAFVSAYLKYFLGVFAYFAAGKAGLKFKTLYGTYLRWPKNSELDSMLKEKFSRVQFDKGMMGGAVIIAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT4</accession>
    <name>K0IHT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57422">
        <property type="protein sequence ID" value="AFU57422"/>
        <property type="gene ID" value="Ngar_c04780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04780"/>
    <dbReference type="HOGENOM" id="CLU_1682750_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-476-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="156" mass="17918" checksum="BFFD533C66996F04" modified="2012-11-28" version="1">MGVELQLEKHFHSIFASFHGSWMCHYYLANIDHYLSFQLAGLADVVTLSNPHVAPRAEFWRGKLWRSLKVASHCLIVLLVERIQLRLQPRYVTLGLPVVHPELDLVYLVVQVPQPLFSNMAITIYQRPAMILLVTILSIRENLLMSHCSCVVFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF8</accession>
    <name>K0IIF8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08950"/>
    <dbReference type="EnsemblBacteria" id="AFU57837">
        <property type="protein sequence ID" value="AFU57837"/>
        <property type="gene ID" value="Ngar_c08950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08950"/>
    <dbReference type="HOGENOM" id="CLU_619140_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-893-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="442" mass="51240" checksum="205C8479139574E1" modified="2012-11-28" version="1">MNIDILKEANPLIIVNQQDAQFLNLNDCKYPSIVVDYERIYGNDFVSQLEKKIASENNDFLIFSSNFLRHLYRFDKGPLLKRFRLGYSSFGGIDLQNTDEQTLKNFNALTSDPSNNYVPGIEDLWVNDESPTRNGTFSLIFDTEQVGCVGIGLERILSLLNKKHCVATFFFTNFVGSIYPQIFEQVHKLGHEVALHGLYHEFLSKRDLNLQDQMIHRMKEHIRVPVYGANFISRMNSLTLEAMFRNDIHYTVFPSIQNFLLGRFGDTEILPYVVRNEQGKMLVMFPVQVETYGREFLPVKGMVTSVYNKLRKTSFSHMTILLHPFRDGSLHRIKELNKLIEYLQDDLDLKAITLRKASENVLSNGSLLNDRKIILPVEDKIFSGSRQFRDILTGKNKRNTNLITVLLNSLVPKNKTDLVYLPVMIRNNMRLLLAHRRHMIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIF9</accession>
    <name>K0IIF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59695">
        <property type="protein sequence ID" value="AFU59695"/>
        <property type="gene ID" value="Ngar_c27740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27740"/>
    <dbReference type="HOGENOM" id="CLU_1521918_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2774-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="20094" checksum="14F9931B270B3532" modified="2012-11-28" version="1">MTLAEILFLLLAAYLIIFVGIAWILGRKYLYTNPIEGKDDEGRKWVIEEHGKSESTSMTLAGFALAALVFVFTANQEQLESAVIELLVIFLSLAFVLEIISALCYKHLYARLYPYYGFVFQYGGLLTILMGFFIFLGDRYPTSEGIWGIYGGAILIFFILTGRELQLYVKQWRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG5</accession>
    <name>K0IIG5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="11">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ctaB2</name>
        <name evidence="11" type="synonym">ctaB</name>
        <name evidence="12" type="ordered locus">Ngar_c18810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18810"/>
    <dbReference type="EnsemblBacteria" id="AFU58813">
        <property type="protein sequence ID" value="AFU58813"/>
        <property type="gene ID" value="Ngar_c18810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1865"/>
    <dbReference type="HOGENOM" id="CLU_029631_0_1_2"/>
    <dbReference type="OMA" id="QFFWQFP"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU58813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="301" mass="32755" checksum="10FA42CFFD04F8AC" modified="2012-11-28" version="1">MTARDYVEVSKPRIVVVLVITAVTSYLAATRFDATPGVAWDVDWFTLGFLTLAGALASMGASALNHYYDRDIDKVMERTARRPIPAGRLLPKSVLAYGIAVSAVSVIIAWFTLNPVATGMIALGIFFYVIIYTAWLKRSNASNIIIGGFAGSAASMAGWAAVTGSMDLLGFLVGWLVFMWTPPHFWCLAIRAREEYASVRVPMLPVLIGNQKTASYILLNTAILLPYSVAIAFFGPGVLYTAVAAVSGSLMLAYHYKLTKNPTPEFAWKAYKVTAPYLVAIFVALAVDALFYYPLPIQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ5</accession>
    <name>K0IIJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09230</name>
        <name evidence="4" type="ordered locus">Ngar_c09550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Enrichment culture Ga9.2</strain>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09230"/>
    <dbReference type="EnsemblBacteria" id="AFU57865">
        <property type="protein sequence ID" value="AFU57865"/>
        <property type="gene ID" value="Ngar_c09230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57897">
        <property type="protein sequence ID" value="AFU57897"/>
        <property type="gene ID" value="Ngar_c09550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09230"/>
    <dbReference type="KEGG" id="nga:Ngar_c09550"/>
    <dbReference type="HOGENOM" id="CLU_124929_0_0_2"/>
    <dbReference type="OMA" id="GIQEEYW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-921-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="2">
        <location>
            <begin position="95"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="18376" checksum="1CAB20097C816F6A" modified="2012-11-28" version="1">MASDMSELERLYKAESDPEVKERLLLVLKVEEDGMVPSRVAEELLHRSRTWASEWMARYRQEGVDGLKTRPKSGRPPDIPPEVALRIQKKLKESKQGWTTRQAYELIVKESGVKYHHKHIYKVLHRWGFKQKVPRKVHINTASDEEKESFKKGRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK3</accession>
    <name>K0IIK3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58888">
        <property type="protein sequence ID" value="AFU58888"/>
        <property type="gene ID" value="Ngar_c19560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19560"/>
    <dbReference type="HOGENOM" id="CLU_1253548_0_0_2"/>
    <dbReference type="OMA" id="INGVHYG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1954-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="236" mass="26298" checksum="C4DD848A04B29BC2" modified="2012-11-28" version="1">MVVRCATMTSGKCTYCSQSFAGPSMGHHLESCKEREMSLMSRITGAASKGSDKAESRVFLIKAWSRYMPEYWLFVDANTRCRLTDIDSFLRRTWLECCGHLSHFIIDDEEYESYPDPDFGSDQDMRVALDTILAPGMTFDYEYDYGSTTELVLKVVAVRPGKLKRGPVVLAARNDPISFECTSCKKAAATDVCAVCFWEGPEAMFCASCLKRHKCGEDMALPIVNSPRTGVCGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL1</accession>
    <name>K0IIL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58898">
        <property type="protein sequence ID" value="AFU58898"/>
        <property type="gene ID" value="Ngar_c19660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19660"/>
    <dbReference type="HOGENOM" id="CLU_140797_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1964-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="13557" checksum="1B7D480641082E3C" modified="2012-11-28" version="1">MWTTYRFYAADRVNFSVNETNAVFSGLVRRFGFAKGLAVQLAIIEIPTAMVLVVLLYHVYYAFTEHYSNGVVAVLNSPVSLLSYLPAALCLFGVIHMIDAFVNLNMEREEKNRSGINSGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM2</accession>
    <name>K0IIM2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59765">
        <property type="protein sequence ID" value="AFU59765"/>
        <property type="gene ID" value="Ngar_c28450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28450"/>
    <dbReference type="HOGENOM" id="CLU_157016_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2845-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="14086" checksum="134277576E444F79" modified="2012-11-28" version="1">MEGTDQCRKVCMLDDRILLVAIIENANLLGMYSKKPMAPPNERRFKVLRIQTELMVSMAKNNEDFFGELGYLMFHSRHLDMFLFPMSRGRKLRIMAVAAKQPYDHEDIVEKITNYLNGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN3</accession>
    <name>K0IIN3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheR</name>
        <name evidence="7" type="ordered locus">Ngar_c10150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10150"/>
    <dbReference type="EnsemblBacteria" id="AFU57957">
        <property type="protein sequence ID" value="AFU57957"/>
        <property type="gene ID" value="Ngar_c10150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.966"/>
    <dbReference type="HOGENOM" id="CLU_025854_1_1_2"/>
    <dbReference type="OMA" id="EWQEFVN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="271" mass="31117" checksum="32E49E742AB18648" modified="2012-11-28" version="1">MSSIEKSADPNLDLILNRLADSGDAQKYRKSFLIRRIDHRMRAKGIRTYQEYAKLLSNDPVEHATLTSLFSVTVTEFFRDIQLFHLLRTTLLPSMVHSNRITKIWCAGCATGEEPYSVALVASELLQTMPGSHRLSVFATDINPNSIRFARSGIYEERNLKNISDEIKSKYFQQVTGKKSWQISPQIREAIIFNVGDLAKVAPPASDLDMILCRNVMIYFDKESRERLLKKFYDALKPKGYLIMGQSEIMIGRTSSLFKTIYTRERVYQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN8</accession>
    <name>K0IIN8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis response regulator CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheY</name>
        <name evidence="2" type="ordered locus">Ngar_c10200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10200"/>
    <dbReference type="EnsemblBacteria" id="AFU57962">
        <property type="protein sequence ID" value="AFU57962"/>
        <property type="gene ID" value="Ngar_c10200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10200"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.971"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="OMA" id="AAGAHEY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="13698" checksum="147EB09CB38D6AE4" modified="2012-11-28" version="1">MSYRGSAKVLVVDDASFMRVVLKDILTASGFQNIVEAGDGATAVSAYQQHRPDLVTMDINMPGTDGIQALRMILQINPAAKVVMVTSVDQKHVVQEAIKLGAKDYVVKPFDRGIVATVVNRVLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP0</accession>
    <name>K0IIP0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH iclR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58933">
        <property type="protein sequence ID" value="AFU58933"/>
        <property type="gene ID" value="Ngar_c20010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20010"/>
    <dbReference type="HOGENOM" id="CLU_1933326_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1999-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14772" checksum="B28D3134A8DA1485" modified="2012-11-28" version="1">MAYLAVYSERLVQMVEHKLEDSMQRLLMPAAHSADIVQEVKALCSLGGCKGGTIMKIVTYLLERDAKTKEIADTFGINISTAHRSLERLEQHGFASKEERSRLWTLNKRRFPLLYSLSRTSTVILSTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY3</accession>
    <name>K0IIY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59945">
        <property type="protein sequence ID" value="AFU59945"/>
        <property type="gene ID" value="Ngar_c30290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30290"/>
    <dbReference type="HOGENOM" id="CLU_2613759_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3029-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="9151" checksum="B57EE978D23B140E" modified="2012-11-28" version="1">MQDTTTNNYYAHDVLYVLDTVTIDSQYRFTITKKIRNFFPVQPGDIFALFEHTKANTLIMKLQRENLIAGAWEIRVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ33</accession>
    <name>K0IJ33_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60025">
        <property type="protein sequence ID" value="AFU60025"/>
        <property type="gene ID" value="Ngar_c31090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31090"/>
    <dbReference type="HOGENOM" id="CLU_128582_0_1_2"/>
    <dbReference type="OMA" id="VEPEMSI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3109-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13492" checksum="19F2BD595D6C54E0" modified="2012-11-28" version="1">MDFEKLCMQVFALNDGIRYAGVIDSTGSPIAGGMRNGIDSIVSETDEELFLTQTALRKSMRERFDDAMGRARFAYVEREKISILTFYMEDKILLVTLEPNIESHTAMDIADDTMKLLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA1</accession>
    <name>K0IJA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NOL1/NOP2/sun family putative RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c13900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13900"/>
    <dbReference type="EnsemblBacteria" id="AFU58327">
        <property type="protein sequence ID" value="AFU58327"/>
        <property type="gene ID" value="Ngar_c13900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13900"/>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_2"/>
    <dbReference type="OMA" id="EPEENEF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1388-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
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        <property type="entry name" value="RCMT"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="4">
        <location>
            <begin position="38"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="318" mass="35761" checksum="ACD9B89137833C00" modified="2012-11-28" version="1">MTLIFPDSAESASLAAKYGYDRWLVSRFLEYVPDIQDFMDRMERPPTQYIRVNTLKIGRDELEARLRSKGFELKRTVIPEVLAVEKAPMATGATNEYLLGHYYIQDLSSCMAVDALDVSKDQIVLDIAAAPGGKTTFMAQRMENTGSIVALEPNDRRARAMSFNLARCGVYNTCILRMDGLEVEKLQAKFDRVLLDAPCSCEGVIAKDTTRKTSHTRQDIDFCASRQDRLIEAAARMVKAGGILVYSTCSFAPEENEMVVDRLLQKFDNITIEPLKYGTSGLTRFGDIVFDGRLKNARRLYPHIHDTTGFFIARLKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE0</accession>
    <name>K0IJE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
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        <lineage>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="Ngar_c23220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23220"/>
    <dbReference type="HOGENOM" id="CLU_009583_32_0_2"/>
    <dbReference type="OMA" id="VSSWVNQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2320-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="2">
        <location>
            <begin position="3"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="300"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="499" mass="56522" checksum="CD0C3ACED6E74832" modified="2012-11-28" version="1">MKKVLLVNWDSYPNVMSGGVYSWEKTLVESMTDYEFTVINLLSNPNVNGKFTVPPHVKQVIDLPLFGSNRYEEFYTDKNRPLLDKIARTKDHIIVEEFMPLYRKFLASIFSNNCDPAELSQIVYRLHRFLSVYDSKKCLEHTLAWETFLDQLECDPLYREMTMREALTAFQIVQRNMQILSLEVPRVDLVHCSLAWFPAMIAVSAKIEHDCPIIITEHGVAFRELLLYYNAFLRDEPSNIFWKLFSANVVRTVYSMADVIAPVCYANAKWEESLGAEPSKIKVIYNGVDATKFRPLDLKREDTRPTVACIGRVDVFKDIVNLIQSIRYVKDRVPDIQCLIYGASTDLEYSLRCVNMVSALGLQGNIRFMGKVKDPEIAYNAADVIVVSSITEGFPFAVIEAMACGKGIVATDVGGIREALEGCGLLVRSSHPQELANAIVQLLQDENLRSRLGAAALERARKGFTIEQSLGQYREQYKRLTEAQQSRAPVAKEEVAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE8</accession>
    <name>K0IJE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative cytochrome b/b6/petB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">petB</name>
        <name evidence="14" type="ordered locus">Ngar_c14510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14510"/>
    <dbReference type="EnsemblBacteria" id="AFU58387">
        <property type="protein sequence ID" value="AFU58387"/>
        <property type="gene ID" value="Ngar_c14510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1415"/>
    <dbReference type="HOGENOM" id="CLU_515465_0_0_2"/>
    <dbReference type="OMA" id="HIRNIHY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="12">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="13">
        <location>
            <begin position="215"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU58387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="514" mass="56996" checksum="8BC582A4BEDA65DE" modified="2012-11-28" version="1">MKFTFPGRFVSPLGFLGMLTFVIFIILGITGALLMLWYEPILTRAWDSVKMINDTIPYGFHIRNIHYHASNAMVMMALLHMYYQYFSGRYKIRNEILWVTGIILGVLTILEAFTGYDIIFSERAELAISIAASLTNSIPILGPQMREAFFGAGFHDFILRFYTFHVFMLPIALLGLMVVHFPRFLVFDVPMVMAVAGAIMLTGGVFPVGLGLKFDPNVPPGITVPEWYLTGLYAFLRTMYDKFVTGVAWPGLFIFALLVVPFVDKYKKFSWKDRPIITALGITSLAQIIVTTYWGFYIDPSIEKALLERLVIDPIFFYLVMILLVPLSFGFTYMMIKLAKHAEANAKLQPKKAAKGSINISQKWIYVLFVVLLAFQVYLNISAYYAMLQGMKNYSLFIIGIIMLVFAGMFHLYRYGRAMAKAPPPKPVPPAPSKPAAAPAAPRPAPAAPAEKPLAAPPTATAAKVGADQKPQLSQQQKQAATGTTGKSAAMSQVQPTTTSIADVDGPDKKATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG4</accession>
    <name>K0IJG4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59298">
        <property type="protein sequence ID" value="AFU59298"/>
        <property type="gene ID" value="Ngar_c23730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23730"/>
    <dbReference type="HOGENOM" id="CLU_2911663_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2371-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8644" checksum="7DB9AF1F84E222CB" modified="2012-11-28" version="1">MDSALLQVAILDDLKSIIEKEIHDLKVNLESNHYQKGEMSERLMSRIADRNDMIRINTLHWVLDVIEKLEQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK2</accession>
    <name>K0IJK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15230"/>
    <dbReference type="EnsemblBacteria" id="AFU58457">
        <property type="protein sequence ID" value="AFU58457"/>
        <property type="gene ID" value="Ngar_c15230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15230"/>
    <dbReference type="HOGENOM" id="CLU_1227618_0_0_2"/>
    <dbReference type="OMA" id="RHESTYP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1521-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="239" mass="27449" checksum="1C722B8DD602E990" modified="2012-11-28" version="1">MAKEQAEPDTKKSIAQPPLNLLFNPSLLVRKDVWNIDVALLLEMFLRLINATGTKDLRICGIAAVSSSMIYRLKVESIFALEKIAMQRKGVDDPDSQQPIPQLNPVELPFRIESTYPVSVEDLLHMLENMIMELANPRPRKKQVELEPVQGFDFDQYLVKFEQIIQRYEDMIFDIVSADGVLMFKTLVEKMEPVETARCFIAMLYLAMKGKVELDQQEGSDDVKITIAKQHNHQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN3</accession>
    <name>K0IJN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59423">
        <property type="protein sequence ID" value="AFU59423"/>
        <property type="gene ID" value="Ngar_c25000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25000"/>
    <dbReference type="HOGENOM" id="CLU_2985806_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2499-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6820" checksum="C2B77CA84896394C" modified="2012-11-28" version="1">MASPAEEVEEIREKTVREQIGLYRQLREQLVQEIERYRREGNDRLASIISESLKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJR7</accession>
    <name>K0IJR7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59463">
        <property type="protein sequence ID" value="AFU59463"/>
        <property type="gene ID" value="Ngar_c25410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25410"/>
    <dbReference type="HOGENOM" id="CLU_951889_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2540-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="287" mass="31564" checksum="E0889FA03FE8B650" modified="2012-11-28" version="1">MPKVPTAVIKFADSIPHPVALIGCRTSETSLDCCEYDLVVFAPENQNNNRVVQVDGLAVELVHFTGPVRNHVVELGSMTVLKDTKFILSSIAKDITPTKYSKALAAAGRKSLISSLFCQQKMKEAKHPAVAAMWLKLAAYDFMGGMLALSGGRPMPLHELEQARQADDASGMAEGVEVALECIGIERATRPVISRSIEAIKELKSKDYDRDLFVSKVDYLLGRSMLADCYYYVGRVAAKNLAGRKDLFHNQYAKLVQLALDLSSDVQHLEKMQKRLFRAANSGLKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT4</accession>
    <name>K0IJT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin-[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">birA</name>
        <name evidence="2" type="ordered locus">Ngar_c15990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15990"/>
    <dbReference type="EnsemblBacteria" id="AFU58532">
        <property type="protein sequence ID" value="AFU58532"/>
        <property type="gene ID" value="Ngar_c15990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1567"/>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_2"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="324" mass="35455" checksum="CC02F72440347EAB" modified="2012-11-28" version="1">MPQPEAFVSLLRSEPGYISGQALAKKAGISRSAVWKQIRMLRRYGYTIESRHGLGYRLAGQTDLPVPWELARVLRTSFIGKHVVYKETTDSTQNIAISLADRSDSHGTVVIAEQQKSGRGRQKRKWLSPKGGIWLSVVLKPGIPTAKITLLPFVAALAVCDAIKNATGLDARLKWPNDVMISGKKVAGILLDISAEADQINYAVIGIGINANVDSAAISARLDGTKITSISDELGHSTSRLDLTRSLLENLEHYYLEMEQQGVGTILQKWKKRSDMLGRKVAVVQNNNKIIQGMATDINDDGSLLLKTDVGDVNVVSGDIHVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJU8</accession>
    <name>K0IJU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c34600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34600"/>
    <dbReference type="EnsemblBacteria" id="AFU60375">
        <property type="protein sequence ID" value="AFU60375"/>
        <property type="gene ID" value="Ngar_c34600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3459"/>
    <dbReference type="HOGENOM" id="CLU_102051_0_0_2"/>
    <dbReference type="OMA" id="MKPNINP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3461-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="21129" checksum="45E31BEE19AD4EF8" modified="2012-11-28" version="1">MLDKDKSKLPVAIKDVLIIGVGVVVIWLVIWASFGSNPFYVVSSGSMVPVLQINDVLVVRDGGSWDDLRVGDIIVFNKPEGEDRVIVHRIAEIDVDSDGDRVIRTKGDANPASIPGTDFPIREDDYIGKVIYVVPGVGVITKIISPPVNYIIIAIILAILFFNRLGKKDDNSSNKGAAPAGGTGNNNNNNPGQPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ6</accession>
    <name>K0IJZ6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">radA1</name>
        <name evidence="5" type="synonym">radA</name>
        <name evidence="10" type="ordered locus">Ngar_c16690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16690"/>
    <dbReference type="EnsemblBacteria" id="AFU58602">
        <property type="protein sequence ID" value="AFU58602"/>
        <property type="gene ID" value="Ngar_c16690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16690"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1646"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="OMA" id="EARICKV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="9">
        <location>
            <begin position="259"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="335" mass="36570" checksum="C81A195074636AF3" modified="2012-11-28" version="1">MAELEIEDIEGIGPTTARKMKEAGISSVMELATAVADELATDLGSSKETAATFIMAAQKLLRESGVLDNEFTTADVELEKRKSLLRCSTGAKALDELLLGGVETQAITEFYGEFGSGKSQICHTLCVTAQQPVEEGGLGGGVILIDTEGTFRPERVDQIARARGLNPEEILKRVAICKAYNSSHLELIVKSMGKYIDDFKAKMIIIDSIISLHRAEFSGRGTLADRQQRLNSIMHKLVRIAEIYNIAIIVTNQVQSTPDTFFGDPTKPAGGNVIGHASTYRVYLRKAGNDRIAKIIDSPYHPYSDVRFTVNEKGVDDIESDAPKKKSAKEKDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK95</accession>
    <name>K0IK95_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c27370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59658">
        <property type="protein sequence ID" value="AFU59658"/>
        <property type="gene ID" value="Ngar_c27370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27370"/>
    <dbReference type="HOGENOM" id="CLU_2285139_0_0_2"/>
    <dbReference type="OMA" id="CKRAINI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2737-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11320" checksum="1E2470DC1E2077FE" modified="2012-11-28" version="1">MLNAGVKQNHAIEIFSAGCPLCRHITDEVEIGKCEGCSQTVYDINNMTDGVKRKMRDYGITSVPATIIDGNIKVVGIPDFPWICSDELYQKLKKEYPLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKA8</accession>
    <name>K0IKA8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="6">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadC</name>
        <name evidence="9" type="ordered locus">Ngar_c18440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18440"/>
    <dbReference type="EnsemblBacteria" id="AFU58777">
        <property type="protein sequence ID" value="AFU58777"/>
        <property type="gene ID" value="Ngar_c18440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18440"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1826"/>
    <dbReference type="HOGENOM" id="CLU_039622_2_0_2"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="8">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="7">
        <location>
            <begin position="115"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="288" mass="30981" checksum="7C73726034712625" modified="2012-11-28" version="1">MQRQDLQTFLDVREMLASFLQEDIGAGDITSNSVIIPGDLFARAEIVCKSGPAVVCGLEEAAIIFDLCGCTSKILVKDGSRVKKGTTVMKVSGNARAILKAERVALNMIMRMSGIATETRRMADLAKGIKILATRKTAPGLRYFDKKAVVMGGGGAHRMRLDDMVLIKDNHLALAGPADKCVRLAKKNAGSSIKVECEAKNLKEVVAAISAGADIVMLDNFTPKQAADAIRHVAKAGLRRKVKIEISGGVNAKNIRQYARAKPDFISLGHITHSPKAVDFSLEIIITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKD8</accession>
    <name>K0IKD8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c19250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19250"/>
    <dbReference type="EnsemblBacteria" id="AFU58857">
        <property type="protein sequence ID" value="AFU58857"/>
        <property type="gene ID" value="Ngar_c19250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1904"/>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OMA" id="RTELWAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1923-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="287"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="397" mass="44494" checksum="5936BDCE4CBC3BB9" modified="2012-11-28" version="1">MSSSSPADIKKKLEQNWIQFLKANSAKLALDAIDGSSPPSVFVGRYGYPKVRIGPMIPPTHGDTTILDRTELWAGKSIEEIANYRLSLVRGVFTMNVHDTSGRYLENMQELAMSERPADSEATFEKKPLADIELDKEVRLNTEAAPFGPAAPLKTFKASSLSADQRIEAAHYDTDLRASDAIMELYRRGVETSGIHRVLSVGMLGLKKNRKLVPTRWSISATDDTISSRLIKENEANPSIDLFEVTQYSHLANYYSVVLIPDEVWSFEMIESWFTSSGQIVMGSDYEDARGLDHYPTIAGAYFAARLAVAEHLAHRCRKAAALVLREIHPEYVMPLGVWQIREGVREALKKPPQKFESIEQAISFASAGMSMSRQEIASKSWLWRAFKNQTRITDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKK2</accession>
    <name>K0IKK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58997">
        <property type="protein sequence ID" value="AFU58997"/>
        <property type="gene ID" value="Ngar_c20650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20650"/>
    <dbReference type="HOGENOM" id="CLU_2949424_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2063-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6942" checksum="EFD577A1F8A09C6D" modified="2012-11-28" version="1">MQVILGMVVSDKEVVRRSRETIEFLKVESIGGVWNTPQLIDMLEDLFKEDSKIYKNKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM2</accession>
    <name>K0IKM2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59843">
        <property type="protein sequence ID" value="AFU59843"/>
        <property type="gene ID" value="Ngar_c29250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29250"/>
    <dbReference type="HOGENOM" id="CLU_1965635_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2925-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14360" checksum="F4FD659BD4C9221D" modified="2012-11-28" version="1">MAVQTTCKFCSYQWPCKGNKARATCPCCKRKNRVNSILASEGPRPQVQVLHSNQVQQEKKDDELKNNPPQVPTSPKLPQVSNEVAPDAQSELSKPEHPVESQQPLTNEQIDKIIMKLAERIRKSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP2</accession>
    <name>K0IKP2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsZ2</name>
        <name evidence="5" type="synonym">ftsZ</name>
        <name evidence="8" type="ordered locus">Ngar_c29650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29650"/>
    <dbReference type="EnsemblBacteria" id="AFU59883">
        <property type="protein sequence ID" value="AFU59883"/>
        <property type="gene ID" value="Ngar_c29650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2937"/>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_2"/>
    <dbReference type="OMA" id="RAMVIMT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="345" mass="36478" checksum="09B0A49B5C2A1E6A" modified="2012-11-28" version="1">MEQETIRAAMEMAKPTVCVIGAGGAGSNIVSWIKSKGISGGKLIAVNTDAAHLGISKADRRILIGPKLTQGRGCGGYPEKGMQATRESMSEITREVQGSNIIFLCAGLGGGTGTGAIQILADELKRATGALVVGVVTLPFAVERFRYSMAKEALLSLQRSCDTVVAIDNNRLTRVAGNLPLQQALGVANELVGQFIKGTTETITTASLINIDFADLTAIMEGRGLAAIGVGFNDGIDRIEQATRMALDTQLLDVKDMSMAHGALVHVTGGDDITLEEVTRAGELVTRSLPQDVRIVWGARVDPAMKGKARVMVVLTGVESTFGEVPKVAQAPVQEEKKKRFLGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKZ6</accession>
    <name>K0IKZ6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hemB1</name>
        <name evidence="12" type="ordered locus">Ngar_c23060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23060"/>
    <dbReference type="EnsemblBacteria" id="AFU59232">
        <property type="protein sequence ID" value="AFU59232"/>
        <property type="gene ID" value="Ngar_c23060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23060"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2281"/>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_2"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU59232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="36222" checksum="6AEF2973D6F26D18" modified="2012-11-28" version="1">MKKSSNSNAFPNVRLRRLRTTPAVRDLLQETRLSAKDLIAPVFVQEGLKKPEEIGSMPDIQRLPLSRLAGEVERIMDLGISAIILFGLPSHKDAEATSAFDDRGIVQKSVELVRKQFGNKVAIVTDVCLCQYTTHGHCGLVVDKKIDNDRSIDTLAKVAVSHAKAGADIVAPSAMMDGQVQAIRKGLDASGFSEVAIMGYSAKQASPLYAPFRDAAHSAPEFGDRCTYQMPFSNAKEAMREIETDIAEGVDIVMIKPAIPYLDLIYKARQATNLPICAYSVSGEYALIKAAAMNGWVDENAVMTEFLTSIKRAGANVIITYQAKKMAELLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL02</accession>
    <name>K0IL02_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-tyrosyl-tRNA(Tyr) deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c23110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23110"/>
    <dbReference type="EnsemblBacteria" id="AFU59237">
        <property type="protein sequence ID" value="AFU59237"/>
        <property type="gene ID" value="Ngar_c23110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2286"/>
    <dbReference type="HOGENOM" id="CLU_056464_1_0_2"/>
    <dbReference type="OMA" id="CYEATHH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2309-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="PTHR34667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="253" mass="27747" checksum="A2D669E38AA49F08" modified="2012-11-28" version="1">MADYLKNSAGFASDDDGKSYRSPRHKNVQLHVASGSLLTLEDLDRDYPDASSFIFLSKHRSDSQIPTLTCHCTGNFADNSYGGNPREIAISYPSLQKGYLKAITAARHKVPEYDIIIEATHHGPTSLKKPILFVELGSSEKQWGDRNAAGVICETLLGLLDRGIERCNKVGIALGGTHYPTKFNKLLLESEFGLAAVASKHNLEAIDEQMLDQMIEKSVEKVTHIVVDGKGLGSQKDRIIKMAEKTGLGIHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL09</accession>
    <name>K0IL09_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gas vesicle protein GvpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gvpD</name>
        <name evidence="2" type="ordered locus">Ngar_c23160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23160"/>
    <dbReference type="EnsemblBacteria" id="AFU59242">
        <property type="protein sequence ID" value="AFU59242"/>
        <property type="gene ID" value="Ngar_c23160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23160"/>
    <dbReference type="HOGENOM" id="CLU_047518_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009788">
        <property type="entry name" value="GvpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07088">
        <property type="entry name" value="GvpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="461" mass="52641" checksum="386CFC2B824794CE" modified="2012-11-28" version="1">MPDELMRFIQRDTYSLLIKGFAGTGKTTLALTILKALESKNNFFYISTRISPKQLFQYYPWLAKFVGQPRPANPAEAPDHGLMTSFEDARLDEPESLFERITNQLMDIKSPVIIIDSWDAIASFMDKEARLNNERVLQTWRERAGAKLIFISEHPDDTTLDFLVDGIVELKQSYYESVRVREIFLLKLRGIRIERPSYIYTLDNSVFRSFVPYRPIKFKPAAEPYRKKIRISNGIATTDYIRSGYPVLDSSLGGGFPRKGTVLLELDPHVNAVVAMAFLERIISNFIFDNNPVLFQPFDWMDPHAIMDYLEPSMPADKKDLFKILWMSKVNGMADNIITMPGKKQRADPIVEALAKMKQKRPDKLLLNIMGTDMMQRSYGRKGIRSGMENLLSDIRTSADLSIAVVSHSQGEVLEYLSEVSDMHLCLMMIKDTLFLQSLVPASTLYAVVFDEHQIGLEPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL76</accession>
    <name>K0IL76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32880"/>
    <dbReference type="EnsemblBacteria" id="AFU60203">
        <property type="protein sequence ID" value="AFU60203"/>
        <property type="gene ID" value="Ngar_c32880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32880"/>
    <dbReference type="HOGENOM" id="CLU_051167_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3288-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="300" mass="35198" checksum="6D6C027B03B2C80D" modified="2012-11-28" version="1">MTTTSNHPQLGHSPVKPILIIGSPGSGTSLLYQILCLHRDAAYISHNMFRAGLRRTGRFLGDRRKALFMLQNLIHRDRDSNLPNEADAFWMMYFGYYNYMTEQDYSEEMATYFRKKVLQVQSLWGRPRFVNKNLQNSFRVRLLNAIFPDAKFVHIIRDGRAVAFSILNKKDGGATSPILLVGFKDILGEKYQSNRSELYNYGLAWAEYVRKAREASAFGRDRYYEVRYENLIAEPYNELKRILDFCELDWYSEFEDRMPPIKDMNKKWIQKATKDQLVEMDESTIDMRRNLGYDNTVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK3</accession>
    <name>K0ILK3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57129">
        <property type="protein sequence ID" value="AFU57129"/>
        <property type="gene ID" value="Ngar_c01800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01800"/>
    <dbReference type="HOGENOM" id="CLU_1127114_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-180-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="246" mass="27883" checksum="7F6F93D71607157B" modified="2012-11-28" version="1">MLHDTAADSVIERKDGRTASTVDVLMELGRQKGFEVEAGKDYGAGPIDVVWHIAIHPALRDITCGFIVMKPLAETLNEAIASGEVKRQQDFEDDRGWQEYRDKEAAFLKDIEEAAMRGVRSGMDRVCLVAENEEAAKAISGKIEWLASHGSLLRMDALCLGLAMDQSSSSVIMPSQKRVPKGEKIRKRAMRRREAKLEKYNRPKGQRKRSEPEERRREREEKLERFSRPKGQKLRNNKDNSSSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM4</accession>
    <name>K0ILM4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrC2</name>
        <name evidence="9" type="ordered locus">Ngar_c35950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35950"/>
    <dbReference type="EnsemblBacteria" id="AFU60508">
        <property type="protein sequence ID" value="AFU60508"/>
        <property type="gene ID" value="Ngar_c35950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3603"/>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_2"/>
    <dbReference type="OMA" id="MLNAICK"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="70"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="407" mass="44142" checksum="BC736F9576CCF278" modified="2012-11-28" version="1">MGSIRSLRCRECGREYEPQFRYVCEECFGPLDVTYNKELSINRHTFESREKTYWRYFELLPIADKSNIVSLNAGLTPLQNADKLGEKLGLKNLFIKNDSVNPTFSFKDRPAGVAVSRAKETKLKAVGCASTGNLAAATAAHAAKAGLPCYIFAPSDIEHVKIAQALSYGAEFVAVEGTYDDANRIASIIGDKKGIGVVNINMRPYYVEGSKTLAYEVAEQLDWRVPDSLIIPVGSGAMLNAICKGFEELHALGVIDSPKSMKVIAAQPHGCAPVVDAWKRNSDEVIPVERPETIAKSLAIGDPGDGIYVLKRLKQYNGFAEEANDQEIADGIMLLAQTEGIFTEPAGGVSVAVLRKLVEEGKIQKDERTVCYVTGNGLKATEAIIGLLPKLNAVKPDATEVAAMIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ2</accession>
    <name>K0ILQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59602">
        <property type="protein sequence ID" value="AFU59602"/>
        <property type="gene ID" value="Ngar_c26810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26810"/>
    <dbReference type="HOGENOM" id="CLU_2079494_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2681-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13502" checksum="B81975B19F3BA551" modified="2012-11-28" version="1">MEAQNVEIALDVYKATRRKFIEAGDAVFGPGFLSMTEYYFMKKKGHSPFAMLFSEPRIVYDEWVWMFKGEEPVRKLLEKAAGPGYMPLLEDIMRNDGVRVWNTFYNMASSRTTAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILS6</accession>
    <name>K0ILS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59647">
        <property type="protein sequence ID" value="AFU59647"/>
        <property type="gene ID" value="Ngar_c27260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27260"/>
    <dbReference type="HOGENOM" id="CLU_3094233_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2726-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5885" checksum="E5CBC332108A785B" modified="2012-11-28" version="1">MICIEIMFCRKFQLVLLVKIAKEAHGTHKVAIMSHAKHCYQRQPSSNDSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM69</accession>
    <name>K0IM69_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57609">
        <property type="protein sequence ID" value="AFU57609"/>
        <property type="gene ID" value="Ngar_c06660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06660"/>
    <dbReference type="HOGENOM" id="CLU_2930306_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-664-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="7045" checksum="DFCC6330CC7EF576" modified="2012-11-28" version="1">MFKIMVNFVVGGKDRKDLNRNVKLLKNTLQARLLYLDSPRFVQEHRLSAQAAVASRFQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD4</accession>
    <name>K0IMD4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57814">
        <property type="protein sequence ID" value="AFU57814"/>
        <property type="gene ID" value="Ngar_c08720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08720"/>
    <dbReference type="HOGENOM" id="CLU_1040581_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-870-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="126"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="248" mass="27553" checksum="FEAF86D5E59AD2C6" modified="2012-11-28" version="1">MPSDYEQACKSIVQAHELIDLAMVIDKFANIVAKASRPSPSSSIGKMSPEDIARTAMRVNIGKGAFNASKNKTGSSSIHARYNAMDMVVQPLDNDLSLIVIGLIDAAKMPELLDLISKTFPTKIKRAIVVDDEPDIRVVIKELLEKRGFQVTLCASGRDCIRTLEKAREDKIEFGVVILDVRMPEMDGFQTFKEIQAISSNTNVLFITAFEYSQKDIAEKISSPKVHLLHKPFSRTELLQSINEVIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME4</accession>
    <name>K0IME4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08970"/>
    <dbReference type="EnsemblBacteria" id="AFU57839">
        <property type="protein sequence ID" value="AFU57839"/>
        <property type="gene ID" value="Ngar_c08970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08970"/>
    <dbReference type="HOGENOM" id="CLU_1302662_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-895-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="211" mass="25134" checksum="33F0CF59F84351A0" modified="2012-11-28" version="1">MLIRIKPKPQPSKRFQRRHVVDSLWQGDTFQFRISGVGRVYVTGFTDDDRSRYRIVSKAYLHRGAKEAINALCHALKKGRIPREMYFDNEKQFIANDFKKELAKFHIKPIYGKPYNPKGRGKVERYHEVLHQELISQVHFSSLSHFRKELRKFDRRYNYWRKSQALGWKTPASVYYDRKYFRKSAIKAATNPCNKTGHKRLHSTVTKVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME8</accession>
    <name>K0IME8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60207">
        <property type="protein sequence ID" value="AFU60207"/>
        <property type="gene ID" value="Ngar_c32920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32920"/>
    <dbReference type="HOGENOM" id="CLU_923222_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3292-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="309" mass="35282" checksum="0E0EB76E1071DB13" modified="2012-11-28" version="1">MVEIPELAPEMASSSISQLLSTLSSNDSLALFMLASNGIKADSSTIEKTGLTKRKYYTRLNQLIDAGLISKYDGIYAHTSLGRIIYQNHILQLMETAKNRKTLQMIDTLRNTKQYSNDEIQNFIEKVVGRPRAMNNPSIDIKFFWSYSELASWIVQRSHYVKREILLASRFFDEVIINAVSSKANAGIDVRVIADRSLIGKFLNEQRGNSLDKVDKHARERKTVTTNPWYPSRVKRIVGQVPFCLMIFDRNEIALELVDWSETQKIKWGITCADEKMAADLTKYYFKLWDATAPTTAQQQEEAASLSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMN0</accession>
    <name>K0IMN0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein sufA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sufA</name>
        <name evidence="2" type="ordered locus">Ngar_c10970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10970"/>
    <dbReference type="EnsemblBacteria" id="AFU58039">
        <property type="protein sequence ID" value="AFU58039"/>
        <property type="gene ID" value="Ngar_c10970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10970"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1039"/>
    <dbReference type="HOGENOM" id="CLU_069054_5_3_2"/>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="12560" checksum="98B656AC66317444" modified="2012-11-28" version="1">MESVQQQTITITPKAAEKVAEFMKQEGNSGLYLRVYVSGGGCAGLSYGMGFEEKPDEDDKVIEQNGVKLLLDSYSQRYLKGANIDYIESLMGSGFKINNPNVTKSCSCGHSFSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR3</accession>
    <name>K0IMR3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11790"/>
    <dbReference type="EnsemblBacteria" id="AFU58119">
        <property type="protein sequence ID" value="AFU58119"/>
        <property type="gene ID" value="Ngar_c11790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11790"/>
    <dbReference type="HOGENOM" id="CLU_1881146_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1177-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="14485" checksum="55A2586C4B73B12C" modified="2012-11-28" version="1">MAAQTDLCSLVGDIAELGSAKRLVDVGSGFSAPAAQWRSSHGSLDISCVNINFQQLLSAMKAEEKMSLLNATSTALPLSDESADRIVALESAQHFRLLEKFISKSRKVLKPNGLLIIVMPVVTQAKPFFKLGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV2</accession>
    <name>K0IMV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative o-methyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c13310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58269">
        <property type="protein sequence ID" value="AFU58269"/>
        <property type="gene ID" value="Ngar_c13310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13310"/>
    <dbReference type="HOGENOM" id="CLU_005533_4_1_2"/>
    <dbReference type="OMA" id="VEFGCFK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1329-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="2">
        <location>
            <begin position="140"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="343" mass="37556" checksum="7AD392F9682FB714" modified="2012-11-28" version="1">MNDQVSPEPIFQMATAYWVSKTLMAAVEFELFTKISNRSVTLEELQKVLGMTARPADVFATALVSLGLLNTSKDGRGGRLFSNSPLSATFLDRNKPSYMGDIISMFDKRLYNMWDKLPQCLLTNKPAGGSGEEMFGQARSNQATEQMQKFTHAMYGVSVGPAMALAKVFDFSKYDSLIDIGGGSGVYAIQAAQANPCLSATIADLAPVCQVADEYIRRFNLQGRVKTKVLDFFKEDIPTGYDVALLSHIIHDWSEEKDVSLLKKIYGSLNSGGAVIISEWLLDDEKTGPAFAALMGMNMIIETEGGRNYSFAEISKMLASAGFSKIEKRPLLGPASVVIGYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMV9</accession>
    <name>K0IMV9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative phosphoribosylamine-glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c13660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13660"/>
    <dbReference type="EnsemblBacteria" id="AFU58304">
        <property type="protein sequence ID" value="AFU58304"/>
        <property type="gene ID" value="Ngar_c13660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1327"/>
    <dbReference type="HOGENOM" id="CLU_362758_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1364-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="9">
        <location>
            <begin position="370"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="770" mass="87964" checksum="E933A0765827C686" modified="2012-11-28" version="1">MKFLFVSPEALSLDLAYTLRQEGNDVKFFIQSATEKDVGDGFVEKVDSWEDQIDWADVIIFDDIGFGKTAEKLREEGKKVVGGSVYTDKLENEREFGQQELAKAGVSVLPNWNFSDFEEAIKFVQSNPGRYVIKPSGKAQNEKELLFVGQEEDGNDVINVLAHYKKNWSNKIKIFQIQQFSSGVEVAVGAFFNGKEFVRPVNINFEHKRLFPGNIGPSTGEMGCYDDKTEVLTDKGWKLFKNLSYEDEICTLNPATHAIEYNKPTAIVSFTHHKKLISMQNRAIDIAVTPDHNMYVCSQENARNANNKFEFVKAKDLQDQSVIKRSGTWIGVEREYFVLPSVSLGHYEGRQIVFHETGQLEVSMDIWAAFMGIWLSEGCASCNKVSIAQKTVQKSKIIEELLRHLPFKFIKGRNEFYCYSKQLYTYLAGFGKAYDKYVPQFIKELSARQIAIFLDWYALGDATVMKSGFRIFYTSSKRMADDIQELLLKIGRVGIVKTRKRRTNRIWIEDHYANCSGIQYEIIERVNKLDSWLDKRDIKTINYEGKVYCATVKNHVMYVRRNGKPYWCGNTLMFWTHNNRIFELTLEKMKPALAASGYVGYIDVNCIANGTGIYPLEFTSRFGYPTISIHMEGITSKWGKLLHSLAKGEDTELHTKKGFQVGVVIAVPPFPFNDDRTFRKFSEDATILFKTQNLDGIHLGEVKREGNDWRIAGRSGYSLVVTGSGNTTDEARAQAYRRVANIMIPNMFYRTDIGSGWVRDSDLLLSYGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN05</accession>
    <name>K0IN05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58534">
        <property type="protein sequence ID" value="AFU58534"/>
        <property type="gene ID" value="Ngar_c16010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16010"/>
    <dbReference type="HOGENOM" id="CLU_193460_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1599-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9742" checksum="9FA4B0819F686339" modified="2012-11-28" version="1">MGVPDLKNNCQDTAFMEPKLEAEKVIAENTAIQEEEKQVEFLEHEIECPRCHDSMVLCSDFDNLYYVCEECDFCLYTIKKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0INA8</accession>
    <name>K0INA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c21180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21180"/>
    <dbReference type="EnsemblBacteria" id="AFU59049">
        <property type="protein sequence ID" value="AFU59049"/>
        <property type="gene ID" value="Ngar_c21180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2100"/>
    <dbReference type="HOGENOM" id="CLU_069532_3_0_2"/>
    <dbReference type="OMA" id="SWDAIDR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2116-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="17924" checksum="EB2DE3DD69476298" modified="2012-11-28" version="1">MAKKVKARPDAQHGNRLESIRDAHNAQKMGRTTRMEDYLEVIYELINQKGYATTVDISSYLNVSSPSVTKMLQRLNESGHVNYEKYRGISLTESGTAVAKNIHDRHGVLAEFLRIIGVDEDTANRDAEGIEHHLHPETLKKLEEFIRLVKSQGLGGLNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC2</accession>
    <name>K0INC2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S_layer_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59119">
        <property type="protein sequence ID" value="AFU59119"/>
        <property type="gene ID" value="Ngar_c21890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21890"/>
    <dbReference type="HOGENOM" id="CLU_878842_0_0_2"/>
    <dbReference type="OMA" id="AWRIMEL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2187-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022651">
        <property type="entry name" value="S_layer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05124">
        <property type="entry name" value="S_layer_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S_layer_C" evidence="1">
        <location>
            <begin position="178"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="316" mass="34707" checksum="663B2CD7E2BE372F" modified="2012-11-28" version="1">MEKKLISESDGQALAKKIVVFRDVERMRVLSNPVAWRIMELLSRGPMYPAQVAKELKIYEQSAYYYIRKLVSIGAVQEVGRNFVRGGTARLYQASSPSFGIEMDWGETKLGSMPAGGHPSTSRFFENFVAGREFKGLIVVGAPDPHGPYKSSARDGHYAVHLAFFLGHITSAVPSEFVVKLDVDAKAEKMLTGNNLITIGGPGTNILTAEFNRYLPVRFDEKNFWSGLIDGSGNRYGLDNHGLIAKIKNPYDSNSSIVVVAGVRSAGTKSAVIALTNYSEEVLKKYNGEDYWALVVQGFDMNSDGKIDHVDIVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND1</accession>
    <name>K0IND1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59164">
        <property type="protein sequence ID" value="AFU59164"/>
        <property type="gene ID" value="Ngar_c22340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22340"/>
    <dbReference type="HOGENOM" id="CLU_1840645_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2232-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15632" checksum="FD28255048283C15" modified="2012-11-28" version="1">MERGDRVLGDNTVRFINIEPRALFDHAFDIYVYTTGYLSYYLSPDTPLSDVAAGIINETTSDLQDIQLSDQIGGPIIDGNPPISIAYMYTDRLYGDTSAIRTITIDQNNVYDFLYQARPESFSEAIPIMNEILASFRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING7</accession>
    <name>K0ING7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59344">
        <property type="protein sequence ID" value="AFU59344"/>
        <property type="gene ID" value="Ngar_c24200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24200"/>
    <dbReference type="HOGENOM" id="CLU_3039181_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2418-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6183" checksum="E75E3B5E4EDAD027" modified="2012-11-28" version="1">MPFCRISAASAKSTRPVLFGSNVLFFNSIQAYLDRARRLLHVSDRARVWFPCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL6</accession>
    <name>K0INL6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59589">
        <property type="protein sequence ID" value="AFU59589"/>
        <property type="gene ID" value="Ngar_c26680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26680"/>
    <dbReference type="HOGENOM" id="CLU_665016_0_0_2"/>
    <dbReference type="OMA" id="HEPRIYL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2668-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="418" mass="47928" checksum="82557EEF89CA63EC" modified="2012-11-28" version="1">MGRSSAAAAARIARQASKLKAMVRSHSSRTDENFKVGVEIELCLIDAKGEPVNAKPAIERLRRYHDIDYEYGKCQLEYKTEPVSFDRLIRLNSQFEEFIEHLDMVVNRVFKRDVFPVFLGANPSPHVLKGGLVTRKPRYLQLARWQRRLPDIEIDGQKIKALHAAAAIQGFHLHLQGKNPNFTAQMFNHILNLIPAAILLGANSRLFAGRVFSLHEPRIYLYDQTEQQNSGFPGIPRYLAGVEDYIDYIVSRKPVIAKDYFGLVKERHDDARIRLNTGFYRVETRVMSVQPTPKTMMALTEFFAGYLHKAIHEERALRPLASIREERQAVVRSGFNARTHFNIIETVRSQLDYARKGLANLGVKPDFLGILEKRLENRTTAGEYVANMWQSKYGDREHALQEVVWNVWQKTKSNSPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP3</accession>
    <name>K0INP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28040"/>
    <dbReference type="EnsemblBacteria" id="AFU59724">
        <property type="protein sequence ID" value="AFU59724"/>
        <property type="gene ID" value="Ngar_c28040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28040"/>
    <dbReference type="HOGENOM" id="CLU_1168605_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2804-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="237" mass="26859" checksum="A4208BBBEBC91984" modified="2012-11-28" version="1">MSPANPENLYVIYYGHLVDENGAMTDQASRILAAKPELVIVPHSFPDGELNLTPDVRWQFSEADIKVLTYTWTDYGARDLNAVRADIDSQMASGVDGIFVDEVTNIETDAEHSYYAAVYQHIKSHGQDKLAIMNPGHYKVNESIMQISDIVSLEEEWVYHDQISWMDKYLPSRFMGVSSNEYCTACISESNAMSKTAEAWSAGIGYHFSTDKYIDLPAWFDSYALQVEEERKARQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS8</accession>
    <name>K0INS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59899">
        <property type="protein sequence ID" value="AFU59899"/>
        <property type="gene ID" value="Ngar_c29810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29810"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2981-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="181" mass="20343" checksum="0C76BC2B6E700D5E" modified="2012-11-28" version="1">MVSGKYFNKGVKALDSPHVGHVVRETSDKIVVFGGGDDRYDIPKSTIRFAAGNVLIDLPFYEIVRKYKVDRKDPLPADSAPSIDLPEPVDLATYEGKYPKSLFNKGVRTQDEEHVGHVMRETDDKIVVWGHYDWRFDVPKSKIIAVGRNVILGMDYSDVFKYSVDRNAPLPTGESVETLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV9</accession>
    <name>K0INV9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60054">
        <property type="protein sequence ID" value="AFU60054"/>
        <property type="gene ID" value="Ngar_c31380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31380"/>
    <dbReference type="HOGENOM" id="CLU_610633_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3138-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="448" mass="49451" checksum="1C3D06BBE1B4165C" modified="2012-11-28" version="1">MSEVDEDNDSRTIIPYVGVDRVIETVQALYKAHAREIGISELATLIDCKVSNINDVSLAMGLPGLSETVNGKIVLTSEGMVFAQAMASNEEEKAKQIIKAAVGKSEVLKFVKSLLEARSEISGEEIGRALMDRFKKNWKDVRTYRAFGNSCASIISFAGYGYFGNGVLSLNAVTKKAKSDIYPPEIGYNPMISLLTVLNGYERAKLSELSQKLGTGDRSLWAHLAICGALGLVEKDLSGSYRITETGRKLLDPTLSADKKSDIFRACLYGSHYADVIRKMASADRDLTANDIGGILTFHLKRDWSPDTKEIYGKKFLTWLNAANLAVKSQRGLYRVKSDEAATIVAAEVSQPKTEKIDYLPIFEIGRHLGALEALAEDDRSKSFSDKVAGLKLLLQDHPDLGMLIDMLKTNYELAIASNNPSIFKTNLDFVRQKIKERMKLEAMEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP06</accession>
    <name>K0IP06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60289">
        <property type="protein sequence ID" value="AFU60289"/>
        <property type="gene ID" value="Ngar_c33740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33740"/>
    <dbReference type="HOGENOM" id="CLU_2379252_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3374-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="12374" checksum="3E096326F5758668" modified="2012-11-28" version="1">MSQDQFLYLTTTGWKTGRKHEIETWFVEHKKKYYIMSEGRERAHWVQNIIHDPAVSFSVGGKNFAGTGRVVVVDDDGKEEPLVAEIKRLMKSKYRWDSGMIVELAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP22</accession>
    <name>K0IP22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60369">
        <property type="protein sequence ID" value="AFU60369"/>
        <property type="gene ID" value="Ngar_c34540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34540"/>
    <dbReference type="HOGENOM" id="CLU_1648360_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3455-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="160" mass="17866" checksum="2DB9414EBA3B0E60" modified="2012-11-28" version="1">MASKKGIALTIGIAAAIIGSSFLIWYIPQSSPGGFIDAPRTDSEVIGDVYARHNDLATSIELRFEQWKNNNDTAVAGDMPAQLASAKSQIEQMRRDLDNHQPAQEWQESYDIYMQALDSYAVYLDALELKVDSGDKTDPDQTLDQRWRDLVDQSVEAMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP31</accession>
    <name>K0IP31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA methylase N-4/N-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c35010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60414">
        <property type="protein sequence ID" value="AFU60414"/>
        <property type="gene ID" value="Ngar_c35010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35010"/>
    <dbReference type="HOGENOM" id="CLU_2679067_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3502-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="74" mass="8734" checksum="E1CBD20964E61065" modified="2012-11-28" version="1">MLIMMATRLIELHCVLKPTGSLWLHCDPNSSHYLKLMLDGIFEPHNFRNEIIWRRSHPKGHAFTRFASNHDTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP43</accession>
    <name>K0IP43_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60474">
        <property type="protein sequence ID" value="AFU60474"/>
        <property type="gene ID" value="Ngar_c35610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35610"/>
    <dbReference type="HOGENOM" id="CLU_2802406_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3562-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7752" checksum="5540006BFB05C415" modified="2012-11-28" version="1">MASHANNSEYQIEYIDGNPVVLGTRSLNWNGTEYTINTLNLFQARDSYYIQSMLAYEELMKIARSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7S4</accession>
    <name>K0I7S4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57316">
        <property type="protein sequence ID" value="AFU57316"/>
        <property type="gene ID" value="Ngar_c03680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03680"/>
    <dbReference type="HOGENOM" id="CLU_2893365_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-368-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="6842" checksum="942CEC2402D995B1" modified="2012-11-28" version="1">MADETKKAQYVLGAITYDDTTGLVTIEINTPNTALMTEGQKQTIKNEIASWVEFMGWEADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8H8</accession>
    <name>K0I8H8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">cca</name>
        <name evidence="11" type="ordered locus">Ngar_c06380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06380"/>
    <dbReference type="EnsemblBacteria" id="AFU57581">
        <property type="protein sequence ID" value="AFU57581"/>
        <property type="gene ID" value="Ngar_c06380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.616"/>
    <dbReference type="HOGENOM" id="CLU_044679_1_0_2"/>
    <dbReference type="OMA" id="DVDLVPC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="157"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU57581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="450" mass="49971" checksum="88BD98C9BB9602D5" modified="2012-11-28" version="1">MSSVRAIVAKALPLCEPSPSEERRIAAVAQEAKALVDKQVAHMSHMVVGVVFGGSFAKGTWLRGDADIDIFFKVKPSVAVEKFEELGRSVGQDALKAHRPRMRYSDHPYVEAFVKNVRINVVPCYDVEQGKWQSAADRSPFHTEFIGRNFDDEKRRQARLLKKFLKATGIYGAEISTGGFSGYVSEVLVLKYGSFEGVLNAAADWQERQVVSVGDYDPDIVKGFISPIVIIDPVDSRRNLGTAISPESAGRFMLAARAFLDRPSIKFFKKSQRGPETKKKLLQNVLVVEFSHRERSPDIVWGQLKRSVNAVAKQLELADFAVLRSSCVTDEKKSAAMAFLLESMTLPPYTKKKGPEVFRRNDTARFLAGKKKPLVTWVDKEMRVAMLVDRKAIDARKFAKSLLQKAENSGVAKDLIAGKLQIYSGSGRKVKGVAKEAISEVVSTERLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8P7</accession>
    <name>K0I8P7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c07080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07080"/>
    <dbReference type="EnsemblBacteria" id="AFU57651">
        <property type="protein sequence ID" value="AFU57651"/>
        <property type="gene ID" value="Ngar_c07080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07080"/>
    <dbReference type="HOGENOM" id="CLU_060108_2_0_2"/>
    <dbReference type="OMA" id="LNMGLCR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-706-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="297" mass="31895" checksum="962401146F95DAF7" modified="2012-11-28" version="1">MQHHRIDTLRQYLLLIRLPNVFTAPSDIMVGYFATIPLVETNGFHLASLMVSSGLLYIAGIVLNDYFDIEVDRRERPFRPLPSGSIPKEHAMAIALAAIAAANIIALAASPTSFAMSLTLTAAIIAYDYRLKRGRAAAFSMGSTRFLNVILGASIVMSASSGIGTAIFAAALLFAYVIAIMILSRKEVGNEKPKVFAAFSIIFGVIASIVAIGLLVQFQWVFLMNLAIFTAVMAVIFKQLLTATSGSSVPQAVKNMVLSIIILDSVFVAGTAGLLYSLSTLLFIIPAVLLAKKLYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8R4</accession>
    <name>K0I8R4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative iron/lead transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c07230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57666">
        <property type="protein sequence ID" value="AFU57666"/>
        <property type="gene ID" value="Ngar_c07230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.698"/>
    <dbReference type="HOGENOM" id="CLU_374547_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-721-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="785" mass="86707" checksum="D17BD9B79B84D8AA" modified="2012-11-28" version="1">MLEMISPLKNPSTVIVPTLVMLFLIISPLAAFAQQQTNNDDALIIMVNMERIRTQLQLADQSLAAGDTEAAFAHAFIPHTTTFPSIKGQLEELDEQSATELEVRLTDLPIDIRTGDQSVDALRQEISGINALLDGILAKLGLPASDKGMVSQTVVFLLRDAVQSYQLSNGGSNQVEYENTIGLVNVAESKYQSIAASFDERRSAEINSFFAELNSLLEQKADNGSIARLATAIERDFAEELSLSAGSSSAGEHATYFSTIRELLANVVTEVNNGNYELADQYAITAYLDNYEYLETPIEKHDHELMLAIEIEMREELIQMIRAEEPPAAIEEHVNGILTKLDQAEEILANDPSFSKGSGTPAGFANIEELAAGFGTYTGERREMGEANDPAKAAVRNNIDKIRIKLDETLRLYKDGNAEGALLTSRAAYLDSYENVEIPLRPIDPDFTLEMEIKFAELRNLIQARAPYEQVEGKVIEIRRGLDESERLVSGTGVLAPAIAFSTSFSIIFREGLESALIVGAILTYLEASRNERFKKHVYYGIVLAFAATAVTWFVAQFIIEISGASRELIEAIAGVSAVAVLFWVSFWILNKVETKKWIEFVKAKVWKATTTGSVMVFVMLSFFTVYREGFETVLFYQAMISFAKYMEWYVVAGMVVGLGVITAVTFVVRRLGKKLPLRVLFGLTMGIGAYMSIAFMGNAVREFQEVGYIPTTHLIGTVPRLDINTATMTGIHPTLETIVAQLVLLGVYLAGSLYVLVIQPRRNRAIESARKSHADLAKKKEDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8V9</accession>
    <name>K0I8V9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57676">
        <property type="protein sequence ID" value="AFU57676"/>
        <property type="gene ID" value="Ngar_c07330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07330"/>
    <dbReference type="HOGENOM" id="CLU_194243_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-731-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8800" checksum="BBE9CBC620D4C7E0" modified="2012-11-28" version="1">MKNMGLGGLALFMTGMWAMILAVAAFLVVFVAPIDVLLFDGQTSSRLTVSAVQAAIAIIVVIALVFGLSKMKRIYLQRKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAC4</accession>
    <name>K0IAC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c13330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13330"/>
    <dbReference type="EnsemblBacteria" id="AFU58271">
        <property type="protein sequence ID" value="AFU58271"/>
        <property type="gene ID" value="Ngar_c13330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13330"/>
    <dbReference type="HOGENOM" id="CLU_055068_1_0_2"/>
    <dbReference type="OMA" id="HIHERAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1331-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="SSF118310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="280" mass="31396" checksum="E5438EFED35D79AE" modified="2012-11-28" version="1">MRCDLCGTDEAIPFKCRYCKGTFCSVHRLPPNHDCVFMKDYLEQPARDREFLEHIHERAGMPHERIRSALYDMIYLRFSKTEVLHLAIATALVTAVGMSIYGFPFRSGFVRWELITIFISAFIIHELGHKFLAQFYRAWAEFRVLLFGAVITAISALPILPFKFIAPGVVWVSGNLSQSRSGRVSWIGPLTNLAMGTGFLVSYLLLTATGSENSILLAGVRFNGFIAFFNLIPFMGLDGQKIFAWNKLVWVLTFAAAIGLYIGGDLLGGGGTIGFLRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAL2</accession>
    <name>K0IAL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like protein</fullName>
            <ecNumber evidence="2">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gloB</name>
        <name evidence="2" type="ordered locus">Ngar_c14250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14250"/>
    <dbReference type="EnsemblBacteria" id="AFU58361">
        <property type="protein sequence ID" value="AFU58361"/>
        <property type="gene ID" value="Ngar_c14250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1391"/>
    <dbReference type="HOGENOM" id="CLU_030571_5_3_2"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="57"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="251" mass="27705" checksum="56B8E1E2DDE98D87" modified="2012-11-28" version="1">MCQGRRHDHLPPAQNWAYKGEKVHGAGARGVDRDTAGGGIRRPMNPVVLQIPVGQMANFTYIIADEESGDAAVIDPSWDLDEVFRALKKNGWRAKYVINTHTHFDHVLGNEQLAEVTGAKIVQHKNSQLGKDIAVSDGDVIEIGSLKLRVLHTPGHSKDSMCLILDGRLVFTGDTLFVGNCGRTDLPGSDPAEMYHSLFDRLAKLDDKLIVYPGHNYGTTPTSTIEREKKTNYLLQPRSKQEFLAFMSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAP5</accession>
    <name>K0IAP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Rieske [2Fe-2S] domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c14700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14700"/>
    <dbReference type="EnsemblBacteria" id="AFU58406">
        <property type="protein sequence ID" value="AFU58406"/>
        <property type="gene ID" value="Ngar_c14700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14700"/>
    <dbReference type="HOGENOM" id="CLU_1478847_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1468-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="64"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="21069" checksum="11670D2AE4C00AD2" modified="2012-11-28" version="1">MSRRDFLKLMAAAGTVMTFAPFVDWGKFLPNNRANGAEKTKIEIRGGEPSNIYSFKVNHSEVVIYPKTDDPVLNTEAFRTWQLIRLPLELGGGKNDVSAFRLYSMVCLHLWCLWRYESKLNMIACPCHASAYDPLTGKAYAGPASLQSPPSNVLPRLDLEADANGDLWILPPTWDARKNGVVGYGRHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB00</accession>
    <name>K0IB00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15830"/>
    <dbReference type="EnsemblBacteria" id="AFU58516">
        <property type="protein sequence ID" value="AFU58516"/>
        <property type="gene ID" value="Ngar_c15830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15830"/>
    <dbReference type="HOGENOM" id="CLU_1933172_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1581-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="15273" checksum="629CECCBD2085F33" modified="2012-11-28" version="1">MKKLQSSSTNSLRIIVSQAWPREDEMLIDRANNGVKISSLVGHNTILPTNVIENIMQRINELISKGIFERKMMEWVSVALFIADSQEATIAFPNTKREVDMNTMFVWEDPMFCEWCSDYFEYMWKDSKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB16</accession>
    <name>K0IB16_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58531">
        <property type="protein sequence ID" value="AFU58531"/>
        <property type="gene ID" value="Ngar_c15980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15980"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1596-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9302" checksum="2F75489744DF66E7" modified="2012-11-28" version="1">MAIILEAANGGITKTKLLTRANLTSGQLRQYLDVLIEKKLITELADEDKRHVAYRTTEKGMRYLSIYSSLKSIAVFPQEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB22</accession>
    <name>K0IB22_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="1">2.4.1.217</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mngA1</name>
        <name evidence="1" type="ordered locus">Ngar_c16030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.217" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16030"/>
    <dbReference type="EnsemblBacteria" id="AFU58536">
        <property type="protein sequence ID" value="AFU58536"/>
        <property type="gene ID" value="Ngar_c16030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1571"/>
    <dbReference type="HOGENOM" id="CLU_028916_0_0_2"/>
    <dbReference type="OMA" id="FAMESEA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050504">
        <property type="term" value="F:mannosyl-3-phosphoglycerate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012812">
        <property type="entry name" value="Osmo_MPG_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09488">
        <property type="entry name" value="Osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02460">
        <property type="entry name" value="osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="396" mass="44797" checksum="7BAAC723B003F152" modified="2012-11-28" version="1">MKLDFPRYTERLGTVSIHAVQRIYELDSGKSKGFQSSHQTVRKFDYDEISNIMHDLAIVIPIKNEKLKLLEGVLSGIPNECLVIIVSNSSRSPVDRFAMESEAVRQLSRFMDKRMIIVHQQDSGLAEVFKKTGYDSILDSEGNIRSGKAEGMIIGLLAAKMYHKDYVGFIDSDNYVPGAVNEYVKIFAAGFGMSTTPYCNVRVSWVFKPKVRNNALQFSKWGRVSEITNRNLNALLAAITGFETEVIKTGNAGEHALSMPLAECLHYTSGYSIETRELIDILEKFGGLMPSEYPQIVDKGVEIFQIETRNPHFHEDKGMAHLNEMLEASLATIFGSKICTPDLKKALQDQLKQMTKKRIDYSKKYHMLEPINAIHMPEFEKGVREKANTFLRIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBS8</accession>
    <name>K0IBS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58721">
        <property type="protein sequence ID" value="AFU58721"/>
        <property type="gene ID" value="Ngar_c17880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17880"/>
    <dbReference type="HOGENOM" id="CLU_2985804_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1786-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6615" checksum="BACF0631A14DA800" modified="2012-11-28" version="1">MMNCPSCGAIMVWLNGSVLHDPPVKEYKCRRCQLFVVKYPDGNYEAKPIEQNQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBT1</accession>
    <name>K0IBT1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17930"/>
    <dbReference type="EnsemblBacteria" id="AFU58726">
        <property type="protein sequence ID" value="AFU58726"/>
        <property type="gene ID" value="Ngar_c17930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17930"/>
    <dbReference type="HOGENOM" id="CLU_074748_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1791-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="348" mass="40372" checksum="E62F061263F7E9F6" modified="2012-11-28" version="1">MRFAIAGAGVAGSYLGKMLQQRGHDVEIFEASKKEHHWPVCAWGASRHMLEKFSDQAGLDFANYIFHVGQRLRMELPNDNEEYLDLKGLVTYDKHRWENDLLKDVKVTYGVKVTRETFPFDKYDCVIDCTGLHRTLLPKSEQDFLIPAYEYLLENVHGIDEFYVIGYKGAKGYFWYFPLDGGRGYMGAGDVQKKYYGVDEFFKEHPEAKVVKKIGRPIRLAPPKRMEPFYDGDSNIIGVGESIGCVFPMLGEGIIPSLICCDIFLDVLGRSNNNNGKFDFKEYRKRVLDRFDYYDDVYRIVRLKMDGKLSTIKHVNLMMSMYRHMKKEEKRFGFEVSLDKMTRLVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBW1</accession>
    <name>K0IBW1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE``</name>
        <name evidence="2" type="synonym">spt4</name>
        <name evidence="4" type="ordered locus">Ngar_c18430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18430"/>
    <dbReference type="EnsemblBacteria" id="AFU58776">
        <property type="protein sequence ID" value="AFU58776"/>
        <property type="gene ID" value="Ngar_c18430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18430"/>
    <dbReference type="HOGENOM" id="CLU_199467_0_0_2"/>
    <dbReference type="OMA" id="VCRECHR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="6799" checksum="4A2C2FD0C0466E2C" modified="2012-11-28" version="1">MAKEKACRRCKVITTGKVCPNCKSTDLSPDWSGIILVFDPAKSQVARTLDITTPNKYALKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC59</accession>
    <name>K0IC59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58936">
        <property type="protein sequence ID" value="AFU58936"/>
        <property type="gene ID" value="Ngar_c20040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20040"/>
    <dbReference type="HOGENOM" id="CLU_600814_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2002-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="455" mass="49214" checksum="128E0893F14827E6" modified="2012-11-28" version="1">MTKIHYGSKFIIFLLTLSFIAGNDAIFTNGAASAQTDSPAPTLNPARLEPQRVLVFEKPFPNLSDAAINPNTGKLYLVNMSDAVGESSGGHVAVFHTTLNGAIAHSTNIPVSFYPSNLVINPNTNTIYLLHNFNCPEGSTVTVIDGNTDNVTGNIEDNMVMRNWAHGIYDILVNPVINRIYVSNGTAMSIIDGNRNEVLDTIAIVAGGSSNLEDIKHENDKFVRLMAISPENNLIYGVREGNRTLAILDLRSNSIINTDTRLNAVLRENAIDSYPVDMIINSETSILYIMNQAIIPQHPDAGISIPTADIIAVNASTGEIISESMAEVQSFHFDLTLDAKQNRLYALSGSNSFVAIDTSNNKVIGKFYFETGELPNFYPRMVLNPETGILYFVGSDAIIAISTETLTSSTNKDSVPVPEIITDDGADLSLALAISIGAGITGIVAYLAFRKKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICB3</accession>
    <name>K0ICB3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">fen</name>
        <name evidence="15" type="ordered locus">Ngar_c20900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20900"/>
    <dbReference type="EnsemblBacteria" id="AFU59021">
        <property type="protein sequence ID" value="AFU59021"/>
        <property type="gene ID" value="Ngar_c20900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2070"/>
    <dbReference type="HOGENOM" id="CLU_032444_0_0_2"/>
    <dbReference type="OMA" id="GSQDYDS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="53EXOc" evidence="12">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="13">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFU59021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="341" mass="38151" checksum="C62C590A24008CE9" modified="2012-11-28" version="1">MGLDLKPLVTPASLKLPELTGKVVAIDAYNTIYQFLSIIRGPTGEPLANSKGEITSHLSGLFYRNANLLGDNIKLVYVFDGKANELKMAEIQRRSQLKKEATEKYQLAVEEGRIEDARKYGIRTAVLTDKMVEESKKLLSYLGIPYIQAPSDGEAAAAYLTRRELAFAAASQDYDSILFGAKKLVRNLAISGKRKVPNRNVYIDVEPEIFEHDKVLQEIGLTHEQLIDVGILIGTDFNPGGFPGIGPKTALKLIKENGKLENVEKIKHLLPKMPYQEIRDIFLKPEVPKVDRIDFGEVNREKVLDFLCVDKSFSADRVSSTLDKLQKSIANRSQSLEQWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICF5</accession>
    <name>K0ICF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57250">
        <property type="protein sequence ID" value="AFU57250"/>
        <property type="gene ID" value="Ngar_c03020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03020"/>
    <dbReference type="HOGENOM" id="CLU_1324055_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-302-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="24442" checksum="6ADAB9C95E1D2ED1" modified="2012-11-28" version="1">MSTTPERLGEYKDIMLTPDQIDRINKRLENEGEWETWSFMNIDLHIGARAFAMASTMWDKIALSPLFRVEQFESKIKKGSWFLTRDGKWWIKYPTNECRVIVETTYDRLPKRKFVFFDDAGSDKANCLQATYFMHKMAVRFKKIFNELDKSSWLNEKTRIYALGDGLYFTGHPLHLFRHTMAQYYLAATNWSLAYVASLGDGKIQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICL6</accession>
    <name>K0ICL6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F420-0:gamma-L-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cofE1</name>
        <name evidence="9" type="ordered locus">Ngar_c21810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21810"/>
    <dbReference type="EnsemblBacteria" id="AFU59111">
        <property type="protein sequence ID" value="AFU59111"/>
        <property type="gene ID" value="Ngar_c21810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2160"/>
    <dbReference type="HOGENOM" id="CLU_051152_1_1_2"/>
    <dbReference type="OMA" id="KHGFVCA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043773">
        <property type="term" value="F:coenzyme F420-0 gamma-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="245" mass="26433" checksum="65BDC663FC516F21" modified="2012-11-28" version="1">MIQVIPVRISADIKPHDELDAIILGAAGQEIQNGDVLVVAHKIVSKAEGRLVSLADVKPSDKALRMAKEHGKDSRIMELILRESAQILRAKDGIIISETKHGFVCANAGVDQSNVEGDSAVLLPIDPDRSASRLRDAVKKKAGKEIAVVITDTFGRPFREGQTNIAIGVAGLDPIKSYVGSRDMYGRKLRVSEIAVADEMASAAELVMGKAEGVPVAIIRGYKFEKSASSSAKALQRPRERDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICV8</accession>
    <name>K0ICV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57500">
        <property type="protein sequence ID" value="AFU57500"/>
        <property type="gene ID" value="Ngar_c05570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05570"/>
    <dbReference type="HOGENOM" id="CLU_182705_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-555-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6998" checksum="3D0784CD3564A0C8" modified="2012-11-28" version="1">MPVKKIDYSKGMKVCITCDRAIFMGLKDYHCPCCNKSLRTKPQYYGENSKAARESTLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICZ4</accession>
    <name>K0ICZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59241">
        <property type="protein sequence ID" value="AFU59241"/>
        <property type="gene ID" value="Ngar_c23150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23150"/>
    <dbReference type="HOGENOM" id="CLU_2067886_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2313-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11312" checksum="8E8CE6D89B2F00B9" modified="2012-11-28" version="1">MEFENAWLEVKGCADSVQTASVNEQALEVPAISEVLEAAASTNKLHPGMWDYSRRLDKVEVEMVRGALGLSKTAEDGRAVSLSVSVAYKGSCYTLTLFAIKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDG1</accession>
    <name>K0IDG1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycosyl transferase, family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c07320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07320"/>
    <dbReference type="EnsemblBacteria" id="AFU57675">
        <property type="protein sequence ID" value="AFU57675"/>
        <property type="gene ID" value="Ngar_c07320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.707"/>
    <dbReference type="HOGENOM" id="CLU_023982_4_0_2"/>
    <dbReference type="OMA" id="ANEIWIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-730-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="342" mass="36460" checksum="4C768994D101203C" modified="2012-11-28" version="1">MLDVVNLLIYGAIVSAISFFVILFLTPAAIRSLAAKGKTVPDAHKQDKPLIPRPAGPVIMAGIATAEIVLYLLTMNAAVLAVLLATAIAFAVGYIDDSRVMPGWFKPVALLAAAVPLVALNFLYPGEVHSDSLNLIFGRAFIPLLYIPLIFVIMPITGNTINSIDVLNGVASGFIIIATIPLLASIAIFGSHEVFLAALPLLFAAIAFYKYHKFPSRIFPGDSGTLLLGAMYGALAIAGSSEIIGVIALLPAVMNSFLFLASVKRIVEHRQVKARPTVLLDDYKLAASTDSAAPATLVRLIVADRPLGEKEVGYKIFKLAAFTALLAFVSIAIQYYVVIVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDS0</accession>
    <name>K0IDS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57870">
        <property type="protein sequence ID" value="AFU57870"/>
        <property type="gene ID" value="Ngar_c09280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09280"/>
    <dbReference type="HOGENOM" id="CLU_3178698_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-926-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5690" checksum="448F97DFB34FEC1B" modified="2012-11-28" version="1">MTQREAVCIKIVQEVPERERMTSRTNPYQLLLRILSFRERWRPTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDS5</accession>
    <name>K0IDS5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00680</name>
        <name evidence="2" type="ordered locus">Ngar_c09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Enrichment culture Ga9.2</strain>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57018">
        <property type="protein sequence ID" value="AFU57018"/>
        <property type="gene ID" value="Ngar_c00680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57875">
        <property type="protein sequence ID" value="AFU57875"/>
        <property type="gene ID" value="Ngar_c09330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00680"/>
    <dbReference type="KEGG" id="nga:Ngar_c09330"/>
    <dbReference type="HOGENOM" id="CLU_2968561_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-68-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6404" checksum="47738541E91E3574" modified="2012-11-28" version="1">MPRDALNILSVLPKALEGNIHREQSPAGASMKSAAEVRRNDRDELHMDLANMQYIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDT2</accession>
    <name>K0IDT2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">snf7</name>
        <name evidence="2" type="ordered locus">Ngar_c00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56973">
        <property type="protein sequence ID" value="AFU56973"/>
        <property type="gene ID" value="Ngar_c00230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00230"/>
    <dbReference type="HOGENOM" id="CLU_1324054_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="22893" checksum="4BA23DF3F56E5EB0" modified="2012-11-28" version="1">MAGGDKRQQFVSQITTATGVVYNQLTRLKMLDKRFASMEAYYLEQITSNIKSGNNARAKILATELSNVRRLRRTTQHTGLALEAIVIRFSTINEFAKILDTIDPTIEMIKGIHTELTRAIPAASEALSEVSTVTTDVLLNANIKADARISTPVDADALSILNEIEGVLEDEAKAKLPEVPTNIIPVQKQEQEEEQQPAEETRVMVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE24</accession>
    <name>K0IE24_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58015">
        <property type="protein sequence ID" value="AFU58015"/>
        <property type="gene ID" value="Ngar_c10730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10730"/>
    <dbReference type="HOGENOM" id="CLU_2949421_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1071-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6464" checksum="84E2B97FC32EF550" modified="2012-11-28" version="1">MEENIGFGRARIDKEVMKRLGVVEGDINSIKSKAGDIRKMPSSLARVMNISSQNCDPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEB8</accession>
    <name>K0IEB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11800"/>
    <dbReference type="EnsemblBacteria" id="AFU58120">
        <property type="protein sequence ID" value="AFU58120"/>
        <property type="gene ID" value="Ngar_c11800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11800"/>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_2"/>
    <dbReference type="OMA" id="IIIDMQT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1178-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="224" mass="25132" checksum="8389A3BE03D13CEA" modified="2012-11-28" version="1">MQENNGRTHRAGRRAAAVTIKGYELKPTLIVIDTQNGFVSDGGSYDKLGINRSHYKKALPNIIRLVNICRKIGTPIVFTIAVREPSGVDLLTKTHKILPLPREERIEEIPICIKGTWDADIVAELKPDNKEYVITKRRDSAFYGTKLEDLLRKLQVDSVIFCGFDTSMCVETSLRDAFNLGFDVMVVSDATASMNPKRYECTLDDVRSFYGLVVDTNELATELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEC7</accession>
    <name>K0IEC7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger SWIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c11900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58130">
        <property type="protein sequence ID" value="AFU58130"/>
        <property type="gene ID" value="Ngar_c11900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11900"/>
    <dbReference type="HOGENOM" id="CLU_2406452_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1188-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10750" checksum="6F3EB060BD374AEA" modified="2012-11-28" version="1">MRNKRKISSQDLLGMLKRIDRAYGIVELNEKEPVILETDQKEKLYKVRSMKDKDRFYNVDTDIKTCTCPDFNFRFLKCKHIIAAEFASGAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEI9</accession>
    <name>K0IEI9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02350"/>
    <dbReference type="EnsemblBacteria" id="AFU57183">
        <property type="protein sequence ID" value="AFU57183"/>
        <property type="gene ID" value="Ngar_c02350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02350"/>
    <dbReference type="HOGENOM" id="CLU_2392981_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-235-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10282" checksum="B7CE90414FF324B9" modified="2012-11-28" version="1">MIDKSEGAHRIEGRYDLIVKVKAETEHELKELISTNISTIQGIDVSLKNLIYYAMKILNQKVGKGSSRACSECVIVDSLADFGAKDRVSHSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEU2</accession>
    <name>K0IEU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c03340</name>
        <name evidence="4" type="ordered locus">Ngar_c03650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Enrichment culture Ga9.2</strain>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57282">
        <property type="protein sequence ID" value="AFU57282"/>
        <property type="gene ID" value="Ngar_c03340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57313">
        <property type="protein sequence ID" value="AFU57313"/>
        <property type="gene ID" value="Ngar_c03650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03340"/>
    <dbReference type="KEGG" id="nga:Ngar_c03650"/>
    <dbReference type="HOGENOM" id="CLU_2784233_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-334-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7994" checksum="A611DC1F1E4B1127" modified="2012-11-28" version="1">MMSDKERLAREEERNKNQDRDINDLYGKWEEIVKCIRRIERRQWIGMGEQAGIAVLLGFVLAKLFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF78</accession>
    <name>K0IF78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thsA1</name>
        <name evidence="6" type="ordered locus">Ngar_c05300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05300"/>
    <dbReference type="EnsemblBacteria" id="AFU57473">
        <property type="protein sequence ID" value="AFU57473"/>
        <property type="gene ID" value="Ngar_c05300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.506"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="VQFCIDA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="553" mass="59265" checksum="626F1DC70C34C680" modified="2012-11-28" version="1">MNNMSMAPGQVPIVVLKEGTSETKGNQAQRNNITAAKTIAEIVRTSLGPRGMDKMLVDTLGDVTITNDGATILKEIDVQHPAAKMMVEISKSVDNEVGDGTTSTVVLAGSLLERAEELITKNVHPTVVVDGFKKAAQKAIDTLKDIAMKVDPVDKAFLSKIARTSMASKMVAADSKELADMVVSAVLAVAEKSGDQYKVDVDNIKVEKKAGGGIHDTKFIHGIVLDKEVVHGGMPKRIENAKIALVNAALEIEKTEMSAEIRISDPHQMQQFIDEENRMLKAMVDKIAAAGANVLLCQKGIDDIAQHYLAKAGILAVRRIKESDMYKLSRATGARVINNLDELTANDLGYAKLVEERKVETDKWVFVEECKNPKSVSILVRGGSQRVVDEAERSVHDAIMAVKDVVEYPYVLVGGGAPEALASLKLREWAATLSGREQLAAEKFADGIETIPLALAENAGMDPLDTQAQLRSKSSTGKARYGIDVLNGKVADLAAKDIYEPLAVKEQVINAATEAACMILRIDEVIAASKSKDMPKPGGGHGGGSMGGSDMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFC5</accession>
    <name>K0IFC5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60071">
        <property type="protein sequence ID" value="AFU60071"/>
        <property type="gene ID" value="Ngar_c31550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31550"/>
    <dbReference type="HOGENOM" id="CLU_2379510_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3155-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10456" checksum="D2E1E501374EAE46" modified="2012-11-28" version="1">MNAIHATINVLDALTTSYFGKRASGAHTDVLSLLKGIFNASEYQDVQKQFTSLRNLKNASEYQPDLMGNEEAEKAVKWAERIIGKAKEKLKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFD0</accession>
    <name>K0IFD0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60076">
        <property type="protein sequence ID" value="AFU60076"/>
        <property type="gene ID" value="Ngar_c31600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31600"/>
    <dbReference type="HOGENOM" id="CLU_2461868_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3160-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10330" checksum="A90B7E286C89B25B" modified="2012-11-28" version="1">MIFYKTAPYGLLCDHWIEDVMSYNKSKLLLNRVSAIRNEPNTEKRLRMLQQLNDSLPNDMRLDMPSLITNAYVRKALDMIEERLLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFN2</accession>
    <name>K0IFN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58620">
        <property type="protein sequence ID" value="AFU58620"/>
        <property type="gene ID" value="Ngar_c16870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16870"/>
    <dbReference type="HOGENOM" id="CLU_2985802_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1685-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6539" checksum="7B316672B2F8093B" modified="2012-11-28" version="1">MRFAKIGIRPKLKVSQQGDAYEQEADYIASKVVAEPASVQSYQNLSDRNHRVQYLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFS9</accession>
    <name>K0IFS9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c33260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60241">
        <property type="protein sequence ID" value="AFU60241"/>
        <property type="gene ID" value="Ngar_c33260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3315"/>
    <dbReference type="HOGENOM" id="CLU_1127117_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3326-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="2">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="246" mass="27661" checksum="AA44E87AD6F41643" modified="2012-11-28" version="1">MSRSEGKKEQHDSSLDLARSVTAIYGLNLALSYENAAVDRLEQRISQCVVPEVKKSLARHLKQTREQQERLKEQIRILSSSSSSSDTADSGYSSALSVPTAESGRLPIPEPPPFLKTIMDEVGTEREREVWESVNDLIIERAEAIMYRAGMQALELLKADKKTMNVLKKNLKEEEAFAKWLEKNNPRIAKRLMRQQMREGKKKRIAEVATTAATTTEQEEGGRERKKEEEGREEITVTDAGAAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFV2</accession>
    <name>K0IFV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60271">
        <property type="protein sequence ID" value="AFU60271"/>
        <property type="gene ID" value="Ngar_c33560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33560"/>
    <dbReference type="HOGENOM" id="CLU_2340275_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3356-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10928" checksum="5E14D553D8FC81FD" modified="2012-11-28" version="1">MRVDLHAFLCIFKLPESDFLLATTIDWNRLWNNIIIFDMGTTVAATPAIQALSSALLFAFLCTIDNAIWLRFFLFRPSENVLPLHCLQLLSAVGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFX5</accession>
    <name>K0IFX5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60296">
        <property type="protein sequence ID" value="AFU60296"/>
        <property type="gene ID" value="Ngar_c33810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33810"/>
    <dbReference type="HOGENOM" id="CLU_2392997_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3382-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8844" checksum="F539733057C57179" modified="2012-11-28" version="1">MLIIFYPLIGLAAGVASALYLAYNYHPLLLNGAIHAGIFASGLVAMHFAKKLTARTTSWYLAGALPVHLAIHFTVIGDLRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG22</accession>
    <name>K0IG22_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ordered locus">Ngar_c34410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34410"/>
    <dbReference type="EnsemblBacteria" id="AFU60356">
        <property type="protein sequence ID" value="AFU60356"/>
        <property type="gene ID" value="Ngar_c34410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34410"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3439"/>
    <dbReference type="HOGENOM" id="CLU_063339_3_3_2"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU60356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="19864" checksum="FF7CF1B29986C8B6" modified="2012-11-28" version="1">MGTTKAKQFDLRDIVASYPDFPKPGILFRDINPVFRRNDALNYIIDEFYRAYGKAKVDAVAGIESRGFVLATALALKFGKGVVMIRKAGKLPGKTLKKSYDIEYGSAVMELQQNAISKGESVLIADDLIATGGTAVAAAQLVEEIGGKVAGFAFIIELSDLHGADRLRKMGYKVQSLVTYHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH55</accession>
    <name>K0IH55_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59205">
        <property type="protein sequence ID" value="AFU59205"/>
        <property type="gene ID" value="Ngar_c22750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22750"/>
    <dbReference type="HOGENOM" id="CLU_2044489_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2273-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="14139" checksum="5C57599A44BC25CE" modified="2012-11-28" version="1">MADKAYSSRRCYELATELQAIAFILFKKNATGKSFGSSTWSKMYSYFMLHREEFMKHYHQRSNIESTFSMIKKKFGPYVRSRDITAQKNEVLLKILCHNICVVNQEMHELGIQADFKTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH57</accession>
    <name>K0IH57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic acid binding OB-fold tRNA/helicase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22820"/>
    <dbReference type="EnsemblBacteria" id="AFU59210">
        <property type="protein sequence ID" value="AFU59210"/>
        <property type="gene ID" value="Ngar_c22820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22820"/>
    <dbReference type="HOGENOM" id="CLU_110881_2_2_2"/>
    <dbReference type="OMA" id="NEQNDVV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2280-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10142" checksum="79F2DEA39C167DDA" modified="2012-11-28" version="1">MKISELKAGMRNVSVVAKVESVGEPRTVNLKAGGTNTVADAIISDESGKIKLSLWGDDINKIQAGDRISIENGYINTFKGENSLSVGKFGKMTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH62</accession>
    <name>K0IH62_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-utilizing enzyme of the PP-loop superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01930"/>
    <dbReference type="EnsemblBacteria" id="AFU57142">
        <property type="protein sequence ID" value="AFU57142"/>
        <property type="gene ID" value="Ngar_c01930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.193"/>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_2"/>
    <dbReference type="OMA" id="DKPAQPC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-193-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="30135" checksum="BA9DF5EDAFC855A0" modified="2012-11-28" version="1">MDDTFNKLVEWFAKNSGSKVIVALSGGVDSAVVALAAKQALGNDAIAITADYKTLSEEELATARQVAKEIDIDHRVIEYDELENPEFVKNDRMRCYHCRTELGEHLVEEAKKAGAALIVDGTNVDDLSDYRPGIRALRENGVRSPMVELGITKSEIREIAKSFGLSIYDKPSNACLASRIPTGIEVTYEKLQRIETAEIIVKSIFGVRQVRVRDHGDLARVEVGRDELVKIFDVDKLALLDSKLKEIGFKFVSIDAAGYRTGKLVMIDNNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH66</accession>
    <name>K0IH66_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58178">
        <property type="protein sequence ID" value="AFU58178"/>
        <property type="gene ID" value="Ngar_c12380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12380"/>
    <dbReference type="HOGENOM" id="CLU_632562_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1236-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="433" mass="48513" checksum="C20380EE50FFF886" modified="2012-11-28" version="1">MLLYSPVYAQEPEPEPAFASAQIGKRTVIYLPANWTTSATDAELTLTSSVPMKKVTSSDWWNATVVEENKVTFRLLENVNRSSIFLVQTNSTEANYGYELTLNGTKYTGKIEAQAPKDSQFARWVDQKENAATAFIPEAWSADLQIIRPYKSMTGFVFFARDSENTLVYVFQPFMPLHLLPNDSLCDSEQQLCSGSISAEKVREMSLGNAPLIISDMKTPDQYFASEVLPVLRKNLHLYRVESEQMVYALSYENNNSTEMMPAHSVQYSFDVEGKRIEGRAMILTRNHTAGDVGIWNGFIVGVESSQENFGAAMQQAAVMLLTLRFDEKWLDSEQKVLLDNANASDALGAIPELMANSTLADFNVIVPTAAHKMVRTYNNTVVAGYIDKDTKQELHLPLFPDLQHWYLDGDQLVGRKVARNPMNPASSLERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH89</accession>
    <name>K0IH89_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TackOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02090"/>
    <dbReference type="EnsemblBacteria" id="AFU57157">
        <property type="protein sequence ID" value="AFU57157"/>
        <property type="gene ID" value="Ngar_c02090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02090"/>
    <dbReference type="HOGENOM" id="CLU_506824_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-209-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040572">
        <property type="entry name" value="TackOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18551">
        <property type="entry name" value="TackOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TackOD1" evidence="2">
        <location>
            <begin position="204"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="537" mass="58961" checksum="AE8C8E57506E86EC" modified="2012-11-28" version="1">MSYVQFALAPIATLVAGLSFAIFFFRIGKVGPKISNLAFVIWAAGSGVAMWYGSLAFKEQLANAMLFSDFTSLIRNTPYSTLVYGSVQQTAAAALIGIYEITMVAGFVILVNIRSHSHLRSQQQQYLKESENAISGSPQIGVSTVVPASRNDDDDEFDFQTMRQKGDNNRAGTLHYSSAGYKLQENSVAHDAQASSNTLSKEELTIMELFLFGRVSKITPRVDLSKPEGYFFEGAPISNMDTSRLRQILDSLTRKKLLNLEFSDKILSCKSCGSPNIQLRNMCPSCKSMRLSKHNVLEHFACGLVDKQENFQNSNGDLVCPKCHTKLQLIGSDYRNLSQMYICQECNSRNKDLLQMMKCAGCGTELEIGEENEQYLYAYTLNEVAAQKLGDQIKPLGACIAHFRSLGYTVVSPAFVIGKSGTQHIFDALVLGGVQGLETNRRLGGAPYKLANDSSSNMVLEIIISSNQVNLEQITRAYGKMCDVDCESLIFAIPGASDNARSYASGFNIRLVEGKTIEQALERLNILPAVGSSRGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHC5</accession>
    <name>K0IHC5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c13650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58303">
        <property type="protein sequence ID" value="AFU58303"/>
        <property type="gene ID" value="Ngar_c13650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13650"/>
    <dbReference type="HOGENOM" id="CLU_564555_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1363-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="483" mass="55716" checksum="AA1273168D509EA7" modified="2012-11-28" version="1">MAKDQRKAAVQAGYNFRRLEVYTPEEIDHCEKSKNIKRYITAKESQSSNTATAYKTKLQAFAQFVYRKLDKVAIDSLIEEIKAGKRDPYETIQDFVYFLQKERPGDKLSNNVIRESAKTVRKFFKSCKIKVSIEDFNEFVSLPRHEKPKKTGITKNDIIELIASPAAGPRLKTFLMFLGATGPRPIEPCALTERDIEFMDLKAADTSKNASWVNFNPKYDKMRDARRRPLTVEVDRQLRIWLDYKYRERRTTKIGKNGKLVHVTVKPERDPDSLLFAHVHFDGERPTPENLYDTIADEFANLVDLLGRGQRVGAGKGKRRKLTLGRFRSWVKTTYSNLGNRDFGEFMIGHSGSTYYETAGDEAIVKTLRQYERYFTFLDAKALEAIGADQQSKIEELREQLEKNNEKWERFVANFMRLYAEERMMAKFGTPEGQKMMDEERKAFFEYAKQFLAEREGRKEAVATVTTTTTSSTGQEDSISGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ4</accession>
    <name>K0IHQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57357">
        <property type="protein sequence ID" value="AFU57357"/>
        <property type="gene ID" value="Ngar_c04100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04100"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.394"/>
    <dbReference type="HOGENOM" id="CLU_1197665_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-409-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="23323" checksum="BC78E9D3BB11110B" modified="2012-11-28" version="1">MLISRQVTGAPANIQSSQPAGKQYSDDTAWSCMDTHVVLPESLQQIQGYGAFESGLALLPMTAAIMILMIGASSRLISRLSVKTSMVAGLGLLAVAMLLFAATPSSSTTFVTHVLLASLVAAAGMSLAYIPVLTAAVSHARKEESGLASGIVNTSYQIGSALGLAIMVAVASAQTFQAENNGIGSVEALNSGFHLAFIGAAAIAGLAAILALAAIKRASVSSQKEAAMAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT7</accession>
    <name>K0IHT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57432">
        <property type="protein sequence ID" value="AFU57432"/>
        <property type="gene ID" value="Ngar_c04880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04880"/>
    <dbReference type="HOGENOM" id="CLU_165240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-486-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="12909" checksum="C3E1728D1B0A0B88" modified="2012-11-28" version="1">MKQQLIIIAAATAAGILAVTSVPQSYAQYGADSIGTATQEQLLRCEELEIDRNQCNDVTILAKERLLYAQKTTYGNNPDGSGTPYFKGIETFTVIGVLGAIFGGVAGAFYMMGRKGKQVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHW0</accession>
    <name>K0IHW0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57482">
        <property type="protein sequence ID" value="AFU57482"/>
        <property type="gene ID" value="Ngar_c05390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05390"/>
    <dbReference type="HOGENOM" id="CLU_1551870_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-537-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="18863" checksum="1447FCB153ACB5B2" modified="2012-11-28" version="1">MMSDSLAVSVAAGLAIGIGFVLLLILVFGKTSSSIPTVPALMEVQVIDMMKADIKNRVGDNVTVYLYLRDSHDPANVNRPLPLIYYDQEKNLLYFINGTSYTISSSCTPSLACFNIQNMDIAKSVAGRLVYFLDGSYSGEGKSAPAYYFIDAMNGEVVWSYIGEDIYPDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0II07</accession>
    <name>K0II07_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC efflux transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c06490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06490"/>
    <dbReference type="EnsemblBacteria" id="AFU57592">
        <property type="protein sequence ID" value="AFU57592"/>
        <property type="gene ID" value="Ngar_c06490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.627"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="SFYKKDC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-647-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="323" mass="36128" checksum="8D60E0CFFC4695A3" modified="2012-11-28" version="1">MYIRLIKIRNLVKKYYNNNLTAVDDLTLDINENEVFGLLGSNGAGKTTTIHMLATLLRPTSGTATVNGYDIISQPAKVRSSIGIVFQAPSSDDMLTGYENLQLHSMLYSVPRHARQQRIDEVLELVGLTERKHDQVKTYSGGMRRRLEIARGLLHKPKVMFLDEPTLGLDPASRETMWKYVKRLVDEEKVTVILTTHYMEEADMLCDRIGIIDKGKIVALDTPSGLKAGLGGDIIRIKTKTPDAGKTVAQFDFVHKVEQSDGFLVLSVKDAKKALPMLLQHVEAESAEFASPTLNDVFIQITGRNIDKEQAEGGFMERYAKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II53</accession>
    <name>K0II53_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16900"/>
    <dbReference type="EnsemblBacteria" id="AFU58623">
        <property type="protein sequence ID" value="AFU58623"/>
        <property type="gene ID" value="Ngar_c16900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16900"/>
    <dbReference type="HOGENOM" id="CLU_500258_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1688-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="544" mass="61448" checksum="984390BCEA054DC2" modified="2012-11-28" version="1">MPTELKVHPSFFKEFATKTWVSPTEIVKELVENAFDEDATRVLVTVLNNGSIAVEDDAGMDQNGMEKFLLLGSPHKKVESISPKLKRIRTGRYGTGRLSFLTSFESMKIRTKRGNFAKAIVIDADVLDKLYTGNAKLDELKEPALKRDGTELVMTGAKIAVDMFRIMKEIRKLAVLRQPMFEVYIKTADKFKEWNFDGAQVIRAPDIQGHRIPVNLDGGRITGEIIIARRPLSDEERGIAVMVGNHIVTHSNFGFDTKLNRVTGFVRCDTLTTRFADKSAIIEDEEYAKFNQLMKTFVIDTVIPGLTEYEDVLITREESKIYREIDKVLGQAMVETLELEEEVQGYEMVEVKERVRTRKEEGGKHEHRAHAHASRQVADYEEIKPLPPASSGISKADHARQHTVSESGIIYEEGTAPEIAGEVVETVDEAQADGTVIRTRTVRKPILKKTFALKRIGYKVIPYEDETDSRYSFTTDNIVFVNKANPTYKAEAARGDEFLMRHVISIVAEAVAQEKHPEGKEALELQNRLVSEAIRIHDTNVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP5</accession>
    <name>K0IIP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58938">
        <property type="protein sequence ID" value="AFU58938"/>
        <property type="gene ID" value="Ngar_c20060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20060"/>
    <dbReference type="HOGENOM" id="CLU_1718272_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2004-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="16673" checksum="81AB066B39E3CEA4" modified="2012-11-28" version="1">MKRIKGLIIVPLAGIGITILVIAFISNLPKPPKPLDYDPTRISDIISEGDAERAARNAVDESYQMNGYEKGAVRGGALGTTELIYVSKDGNSFAVDKNDGTLGESTFFVVDNIQRDHYYWKVILNLGNTTKPEYDFKIDAHTGIVLQLGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIT2</accession>
    <name>K0IIT2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58022">
        <property type="protein sequence ID" value="AFU58022"/>
        <property type="gene ID" value="Ngar_c10800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10800"/>
    <dbReference type="HOGENOM" id="CLU_2985797_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1078-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6492" checksum="77B5BCFE7953DF65" modified="2012-11-28" version="1">MAVHINKNLAHFRNTMVILVTFSFFKELVMNIDIDIVIFASIRTINTIPLLISGCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY0</accession>
    <name>K0IIY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59940">
        <property type="protein sequence ID" value="AFU59940"/>
        <property type="gene ID" value="Ngar_c30240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30240"/>
    <dbReference type="HOGENOM" id="CLU_2802403_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3024-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7810" checksum="863E1EBA535DA663" modified="2012-11-28" version="1">MHTQNETEPQVAKVFNNAVAIQCAGYSTKRFVVVALERRDLEGFVQYRNDFVKVAAERDDRIIMFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ17</accession>
    <name>K0IJ17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59098">
        <property type="protein sequence ID" value="AFU59098"/>
        <property type="gene ID" value="Ngar_c21680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21680"/>
    <dbReference type="HOGENOM" id="CLU_202280_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2166-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8151" checksum="9FE2009C76481E56" modified="2012-11-28" version="1">MEQNNPRVFKQTTDRSLIVEKEIDLEEPELMLPVFICDNTDAILDPMDQMKFALNEVQLKYGGIVVLKDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD9</accession>
    <name>K0IJD9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="9">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysS2</name>
        <name evidence="9" type="synonym">cysS</name>
        <name evidence="13" type="ordered locus">Ngar_c32240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32240"/>
    <dbReference type="EnsemblBacteria" id="AFU60140">
        <property type="protein sequence ID" value="AFU60140"/>
        <property type="gene ID" value="Ngar_c32240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32240"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3215"/>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="376"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="494" mass="56219" checksum="8497056E29FC191A" modified="2012-11-28" version="1">MLLHRHITPHTCRSGKGKKPGQAALATLKLYSTLSRQLEELKPQDNSTVRMYVCGVTVYDDSHIGHARTVIVFDTLRRYLLSKGYRVVFVQNFTDVDDKIINRARAEGKKAEEISEKYIDSYFRDFGGLNVMPADYHPKATEHINEMIHLIDGLMKKGHAYLTLNGIYFRVKSFPGYGKLSRKPVEELESGARIEVDPTKEDPLDFALWKFSSEDPNWPSPWGKGRPGWHIECSAMSLKYLGETFEIHGGGHDLVFPHHENEIAQSESYTGKQFAKIWIHSGMVTINSQKMSKSLGNIVTIEQALKSWGMNPLRLYCLSVHYAKPLDYTDELLKESVQRWRQIETCAFELRSAAAGSSGGGEVDAVHKMCDESMKAFEAAMDDDMNTSLALTEFLKLVTRMNQYAAAEKLTKEMADAALPTFNRIMNNILGLKTVEAGEEERKEIERLVAARNSLRAEKKFKEADEIRKKLLERSVELLDHKGRTVWVKRERPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJH6</accession>
    <name>K0IJH6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NHL repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">resA</name>
        <name evidence="3" type="ordered locus">Ngar_c24030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59328">
        <property type="protein sequence ID" value="AFU59328"/>
        <property type="gene ID" value="Ngar_c24030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24030"/>
    <dbReference type="HOGENOM" id="CLU_013730_1_0_2"/>
    <dbReference type="OMA" id="IAMAGVH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="501" mass="56148" checksum="3EA874E476858C36" modified="2012-11-28" version="1">MFRRPSLVNSKAKDFQKGFVWLNTDRPLSLDDLKGHVVVLDFWTYCCINCMHTLPDLEWIEKKYRGRPVVVIGVHSAKFYNEQEAENIREAIGRYEISHPVIVDRGMEIWQSYGVSGWPTLVVIDPKGNVVYQQSGEGQREYLDDVISVLLKRHKEQGTLAPEPIEIKRPEAAHSRVLSYPGKLSLSPDGRMLAISDSNHNRILVVDADSGKIIHKVGGGSKDLRDGSFEQARFFRPQGVLWVGYDKIYVADTENHALREIDLQSRMVKTLAGNGKQGYWIQSPQDGKVTQLSSPWDLTHDSGFILIAMAGLHQIWAYHIQTGRIGPFAGSGYENIVDGSLEESQFAQPSGLAVFGNYLFVADSEVSAVRRIDLGRKVVQTAVGEGLFVFGHKDGPLEEARLQHPLGVACESSNKIYVADTYNHAVRLIDLAEQRISTLVGRPEMKTMCNIDDPSCDTLGLYEPSDVEVRGSLLYITDTNNHLVRIFDLEKKVLRTLAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI0</accession>
    <name>K0IJI0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58432">
        <property type="protein sequence ID" value="AFU58432"/>
        <property type="gene ID" value="Ngar_c14970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14970"/>
    <dbReference type="HOGENOM" id="CLU_539276_0_0_2"/>
    <dbReference type="OMA" id="FCENIAG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1495-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="553" mass="62432" checksum="52DF55E1B50B118B" modified="2012-11-28" version="1">MTRLAKFYTVSDPLISGFISSIPLNFSDIIRLLKPFTNVAADPFVLGNRIKLKSSIRRFHSEADTLSSVVSKHIDLLGDPFTQILVSMHQPNLFPYGGIYKKIVLLETLKKKLEEADPNGKIINLFIVIDHEFVDDRWICHAQLPDVHHPSGIMQLTYPIVKSQKRWLVKNVDKPSLMMLDRWRKQIRSWIRETLLVPKSSQTGTTLLNFNKSKVLDNFDHFWAKVESVRHRAKSLADFNAFLLSEMINKVFGYSTLFVRASEISPAVEDGIKYLVSNFHTYSEVLQETEKTLINHGINTRVSTNVYKSAPVWLHCKCGSKASVRLTKSGRQTLLTGICLGCRQVLRQDLGNSDAIDISGSVQNLSLRAVPTPILLARDLGVACLVSGTGGMGYVTDAAVISKMLSVRFPLIALWTSVDIYNGIGQSTALRYLGTQERIDVQPLLGKLEHDNEVYASRIKALTIEKSRMVRNNIPIDQILQEIFALKQEQRKLRKRIELVQRTSNIMNLSSCFIDYAVNFGMDNIESEWRSHLLENGNLAAPIYMNNSADVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI3</accession>
    <name>K0IJI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58437">
        <property type="protein sequence ID" value="AFU58437"/>
        <property type="gene ID" value="Ngar_c15020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15020"/>
    <dbReference type="HOGENOM" id="CLU_1976604_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1500-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="14700" checksum="A3554F43BD64AE10" modified="2012-11-28" version="1">MTASQGEGTFFPLFTIISNNFNKDLYIVKHIFSGFEKLNHTENGFKLSERAEMAAGWWFYDIYVSRDFVTKIFQQLLPEGVRDKKSATIKITDAFQDQLRKHGSEAKIKMHGDIPFAATWWAWLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJJ2</accession>
    <name>K0IJJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative major facilitator superfamily MFS-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32700"/>
    <dbReference type="EnsemblBacteria" id="AFU60185">
        <property type="protein sequence ID" value="AFU60185"/>
        <property type="gene ID" value="Ngar_c32700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32700"/>
    <dbReference type="HOGENOM" id="CLU_656603_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3270-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="400" mass="42972" checksum="067E335ECC87C101" modified="2012-11-28" version="1">MLNYGGGVKEVALAIFLSAIASTIGSLLWGKLIDRMRLRTAVIIVGAASLSILAVCTYFASDISVLILISTMVGFLTAGIGPVTNVFVMERSARKDWVMTSSWITLATCAGIVIAMLAGYLWLMFYQDDARSFAIVCSGLAMISIIMASTLSRNVKPASYLGADKKELSPNAANQGIKSWRSMLGGMTKRECIFLVGLCLYFISGNLFFTPYTPFLKENGISDSEIFLAYTILHLSKVIYLPFNSRATSALGGENNTIKWAYVPRLIGILSIAAFAAGVAGNSATILLTITFVAFIAIDVSFSMWHTATTALFMRGISLGNEGKMFGINGGVVGIGLFLGSVIAGEAAPQFGYTATFSMSAGLFAISFIIMAMLFKNAHQNAKAVSRAFSLRFWMTKRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN4</accession>
    <name>K0IJN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33500"/>
    <dbReference type="EnsemblBacteria" id="AFU60265">
        <property type="protein sequence ID" value="AFU60265"/>
        <property type="gene ID" value="Ngar_c33500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33500"/>
    <dbReference type="HOGENOM" id="CLU_1243059_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3350-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="25280" checksum="BE2B02E996B0CE7B" modified="2012-11-28" version="1">MVDSLAQVNDQLKEHDRLQHEFINIAAHELRTPIQPILRIAEIKENEFNSKDEITISKEEMDLLVRNARRLERLSSDILQVTRIEGRRLKLAKEQFDLNEKVRNVVDDIRNTLGSSADAKKGLLAFNVELPEPAIMVYADKPKIYEMISNLLNNAVKFTENGGTITVSARTEKDGTVVVKVKDTGAGIVPEIMPRLFTKFASQKRGRAWAVHRKEHCRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJT9</accession>
    <name>K0IJT9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60360">
        <property type="protein sequence ID" value="AFU60360"/>
        <property type="gene ID" value="Ngar_c34450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34450"/>
    <dbReference type="HOGENOM" id="CLU_168727_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3446-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13341" checksum="020529F227FC6524" modified="2012-11-28" version="1">MAVNLSNVEQAIVSELKVSEDEAKAFLAIVKKGKMDAAKLSSALGWNDEQRALTAAKSLVGRGMVIEITATEFESLHPRFAITNRYRRCCEEDGIPFKKNLKVDNIGIVLEKPYEDARTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ4</accession>
    <name>K0IJZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60440">
        <property type="protein sequence ID" value="AFU60440"/>
        <property type="gene ID" value="Ngar_c35270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35270"/>
    <dbReference type="HOGENOM" id="CLU_859473_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3528-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="323" mass="32934" checksum="7DF7240D9C0AA68D" modified="2012-11-28" version="1">MFKERKKFALLSILSALVVVSTAFVGVSIYAEGTDDSELTTFEEEAIKAGEKFEDMESKARSDGITDDSSSTTTIAEVSSLFDSLVLCDVGTTEVSGKTQTAGFDKESLTTPTVSVKVMTEAEIANETSTTTTAASSSAADKEETSTTSSSIDCVSMGKGGSTSTASKAKDDGADAATASNGTSTASAPESDDQILVIEGQDFVPRQAVLIFYEGALVGIDEVAKDGSIEIKIPVPNSGGTASTAAGNNTASSAELKFVETGTQRTGIFEFDGETLTAAAEGGEIEAESGDDGAAATMPAPSSDNATTSSESASSNNSNYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK08</accession>
    <name>K0IK08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26410"/>
    <dbReference type="EnsemblBacteria" id="AFU59563">
        <property type="protein sequence ID" value="AFU59563"/>
        <property type="gene ID" value="Ngar_c26410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26410"/>
    <dbReference type="HOGENOM" id="CLU_2712972_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2641-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8590" checksum="DFAF898C853E5E9D" modified="2012-11-28" version="1">MNWHIKRLEDSKIVDEIREGRFKRYKLHRDSKQVAAMLKNFYPSVWDKWSNRLAEMFLSMSGEAAEKRGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK09</accession>
    <name>K0IK09_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60460">
        <property type="protein sequence ID" value="AFU60460"/>
        <property type="gene ID" value="Ngar_c35470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35470"/>
    <dbReference type="HOGENOM" id="CLU_1933329_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3548-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024997">
        <property type="entry name" value="DUF3892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13031">
        <property type="entry name" value="DUF3892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="130" mass="14951" checksum="C7AC183B01C6D6AE" modified="2012-11-28" version="1">MTSCSGVITIFYFSLFIMISSYSIVAAIPTDCTCIEYMGTIDSHYLIPVSEVIELIEKGKDKFYVMDYKTQNKVYVNVAQKKEGMKYIRTEAYDTSYDRLLKVGYCNVTRRAPYESGPMIIQEIRDLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK18</accession>
    <name>K0IK18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pyruvate dehydrogenase/ pyruvate oxidase</fullName>
            <ecNumber evidence="6">1.2.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pox</name>
        <name evidence="6" type="ordered locus">Ngar_c26510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26510"/>
    <dbReference type="EnsemblBacteria" id="AFU59573">
        <property type="protein sequence ID" value="AFU59573"/>
        <property type="gene ID" value="Ngar_c26510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2626"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_2"/>
    <dbReference type="OMA" id="YEATHEC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047112">
        <property type="term" value="F:pyruvate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="219"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="408"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="615" mass="66796" checksum="A15B9B2371F00C40" modified="2012-11-28" version="1">MPACQLNNILLGIHISHMVAEQGTKTAEIVAESLLDWGVDVIFGLPGDGINGFIEALRQRKDRIKFVLVRHEESAAFMACAYAKYTGKLGACVATSGPGAIHLLTGLYDAKADSTPVVAITGSTYSDMMGSNYQQDVNLLQLFSDVTVYNNMINSPEHAEMAVDIACRSAISKRGVSHLTIPIDVQEKQRSGKYSRHKVAGHTSDVFSSCVMPDPAILRKAADILNSGERVVLLVGQGALGAGAEVEAVSEMLGAPIVKALLGKAVVPDDHPNSLGGIGMLGTEPATDAMEQADTLLMVGTSFPYIDYLPKPGRARGIQIDLLPERIGLRFPVEAGLVGDAKTTLAALMPLLKKKENREFLRSRQDAMRSWMDLLRERSSRTDRPVKPQVVAAAVSEELQDDAIISVDSGTNTIWAAQYIQLRRGMKFSLSGTLASMACALPYAIAAQIAYPERQCVAFVGDGGFSMLMAEFATAVQYNLPIKVVIIKNNILGMIRWEQMAFLGNPEYGVEFTPIDFAEFAESCGGRGYSINEPAEVRSIISQAMGEKEPTIIEAYVDPFEPPMPPKVDMDFVRNLAESFARGQPYARRIGLTLFRNQVHETLRGVHSHDTEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK60</accession>
    <name>K0IK60_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/opine/nickel ABC uptake transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">appF</name>
        <name evidence="6" type="ordered locus">Ngar_c26920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26920"/>
    <dbReference type="EnsemblBacteria" id="AFU59613">
        <property type="protein sequence ID" value="AFU59613"/>
        <property type="gene ID" value="Ngar_c26920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26920"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="30484" checksum="1F63105D34821E02" modified="2012-11-28" version="1">MPLDVLLEARNLRKYFPVKKSFRQLLQKSGPDFVKAVDDVSFTLKMGKVLVLAGESGSGKTTVARLVMRATDPDSGSIIFEGKDVTHYAGSQLKEFRTAVHMIYQDPYASLNPRMKIMDIVREPLDIHDKTSSKEQKAEKVLSALRDVRLEPAEEIAGRFPHMLSGGQRQRVAIARALVLRPRLIVADEPVSMLDVSVRGEILELMQSLKERFNISYIYITHDLSTARYVGDILAIMNTGKIVEVGPIDRVLSDPYHPYTKALIGAIPEPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK91</accession>
    <name>K0IK91_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59653">
        <property type="protein sequence ID" value="AFU59653"/>
        <property type="gene ID" value="Ngar_c27320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27320"/>
    <dbReference type="HOGENOM" id="CLU_2217136_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2732-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="12251" checksum="951977D0490DDD9E" modified="2012-11-28" version="1">MISMSHGISDQLMVMPETLVSHGMPIDTAKRKEIAIEYWQNFLAWFNTAYPHMQRTNTIVAYRGFLSSHSINFAHGEGKRYGLSTISERLGEYKDIICLRRSKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC6</accession>
    <name>K0IKC6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c18950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18950"/>
    <dbReference type="EnsemblBacteria" id="AFU58827">
        <property type="protein sequence ID" value="AFU58827"/>
        <property type="gene ID" value="Ngar_c18950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18950"/>
    <dbReference type="HOGENOM" id="CLU_033880_0_0_2"/>
    <dbReference type="OMA" id="WAEMYAT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1893-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="578" mass="66869" checksum="EC73F269915E6112" modified="2012-11-28" version="1">MTTTTILAHFPFPNIREKQRSVLVDIELAIKSGYKHIFLEAPTGFGKTPVAITLARYLGSSHICTATKDLQTQYRRDFPFVVEVKGRGNFACIVKEDMGLDESCDYGPCVKDDAYDCTYKTRLMDYRAEGEGTMHELVKLDSFAERKYIDKMRSKSKLVELEWRPCHYFHQKWIGARSSHTVYNYRYFLSDVFYAGSTQKRNLLVLDEAHQLESEVGDFRSFTIRKNMLPFLKMQMPDSNVDDIETWLDFCIELKEKLFEFSEKAERIIERSNQKVMTEPFTEKNLIDALEREATLTAIIDDMKADKDNWIVSGVQRDNANQLSRVTLMPLEVSGYFDSILDKGSVSLFMSATILSKDYLCKTAGLEPDKVKFIRIEESDFPVKNRLIHMKNTAWLNAKTMNESLPKIAEEVRKIMSDPKHKNQKGIIHTTSYSQLQFIKEFLKNIDHESADRLIETGSGLDRSEVLERHYSSKNPTVLISPSLHLGVDLKDEFSRFQIIVKVPYPDLTDKRIAKMKDKDPKWYTWNTVLRLVQAYGRSVRSKDDYATTYILDSSISYLLKNAQDLVPKWFTEAIVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC8</accession>
    <name>K0IKC8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-lysine exporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysE</name>
        <name evidence="6" type="ordered locus">Ngar_c19000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19000"/>
    <dbReference type="EnsemblBacteria" id="AFU58832">
        <property type="protein sequence ID" value="AFU58832"/>
        <property type="gene ID" value="Ngar_c19000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19000"/>
    <dbReference type="HOGENOM" id="CLU_104651_0_0_2"/>
    <dbReference type="OMA" id="NPYFWIW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="22159" checksum="BF8F14BFADF8E2FB" modified="2012-11-28" version="1">MSVLDFGVEVIAISASGVLAPGPLFFTNLLYGTRQGMRSGIKVAYGHTVVELPLIILLAAGLFTSAAISQYAGAIGLIGGIGILGFASLQIAGVVARRKDVQAAPVMASGKSPFVAGIALSALNPFFLVWWFTVGLKLIADSAAFGLAAGIMILFALHIWMDYAWLAGTAYLASKGSSVIKSKYYPLLLIALAAVLLYYGTTFVLSSLFADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE1</accession>
    <name>K0IKE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutamine amidotransferase class-I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19300"/>
    <dbReference type="EnsemblBacteria" id="AFU58862">
        <property type="protein sequence ID" value="AFU58862"/>
        <property type="gene ID" value="Ngar_c19300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19300"/>
    <dbReference type="HOGENOM" id="CLU_140789_1_0_2"/>
    <dbReference type="OMA" id="YHNNAND"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1928-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="17042" checksum="4E3352E6414C9916" modified="2012-11-28" version="1">MGYQYHNNANDDETVERLRSFIGMLNEESEKGSVIVVEGKRDAEALSKVGFTGSPAVFHHFKGVADFLDSHDSASKKKKIILLLDMDRTGKYLTSRLVSQLQSRRQNVSLSYKRALAKITNGKVRHVEDLVIYAPRLSGITGSRKDLYFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG2</accession>
    <name>K0IKG2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58907">
        <property type="protein sequence ID" value="AFU58907"/>
        <property type="gene ID" value="Ngar_c19750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19750"/>
    <dbReference type="HOGENOM" id="CLU_1656808_0_0_2"/>
    <dbReference type="OMA" id="RKHIVGA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1973-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="176" mass="18623" checksum="B8E5CC6AA12F391F" modified="2012-11-28" version="1">MSYNAKRSLSRGLAVSGITIAAYLLIVVVTTPSLPPLAAVNTAFAINSPIIFGTAAGTGTQSFISSYGKRMGCQLNKRKHIVGAGSGSTAFSSFLSFFSLVPLGCCGSWLFILSFLPSIFGSTLSVVLIQYSTPLSYIGLSIVLGFAGLSAFKLNRELRLRKYLAQGKDRGSNHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI1</accession>
    <name>K0IKI1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59778">
        <property type="protein sequence ID" value="AFU59778"/>
        <property type="gene ID" value="Ngar_c28590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28590"/>
    <dbReference type="HOGENOM" id="CLU_2857216_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2859-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7127" checksum="2CE77A82DB029A91" modified="2012-11-28" version="1">MHIYILIAIWFVGIATAAVALFMPVYSDYVIVGVVGWITVGASTGLILYEIKRIRAEDRKKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKL1</accession>
    <name>K0IKL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59017">
        <property type="protein sequence ID" value="AFU59017"/>
        <property type="gene ID" value="Ngar_c20860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20860"/>
    <dbReference type="HOGENOM" id="CLU_2949425_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2084-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6798" checksum="6F81C6E8FD917A37" modified="2012-11-28" version="1">MLCETCYWCATYLDKTKVVDKCPLCSATVMSSFPIMPDESFVFSYDAKRGIELDFGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL06</accession>
    <name>K0IL06_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c31720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31720"/>
    <dbReference type="EnsemblBacteria" id="AFU60088">
        <property type="protein sequence ID" value="AFU60088"/>
        <property type="gene ID" value="Ngar_c31720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31720"/>
    <dbReference type="HOGENOM" id="CLU_056931_3_0_2"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3172-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="245" mass="27447" checksum="BF43BD68538D1BB1" modified="2012-11-28" version="1">MVIAVALVEPQYHVNVGHVARLMENFGLKRLYFIKPHFDRVEALKYSTHGKDVLETAKTATLKQLRKKFDILIGTTAIPATSRLNVLREATGAEQIAKIIHSGDGKNFCIVLGRESSGLNNEELAMCDLVVIIDTKTKYRTMNIAHALAIMLYEISKLKPELPVKKSKKKIDLASQQDIDLLLHYVGKVADAGNYDAHKKPLLEAAVKKMLAKSVPTTKDVMLMVSLLRRSLLAIERRKRRAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL23</accession>
    <name>K0IL23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60113">
        <property type="protein sequence ID" value="AFU60113"/>
        <property type="gene ID" value="Ngar_c31970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31970"/>
    <dbReference type="HOGENOM" id="CLU_1754762_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3197-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16499" checksum="C1FA5F1DDFA44171" modified="2012-11-28" version="1">MQITATSLEEGKLDEKLEMLIDQFEREVAPYDRWSRISMAATSAGVVASIVLPLLLLQPAHALYATIAGIAASIGLTKLPILYADHKKHEISRVKYKPVTGVCMCDLYQYRTHLHKMQNANNTAERIRHSKLASYYKHQMGLGSAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL38</accession>
    <name>K0IL38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59307">
        <property type="protein sequence ID" value="AFU59307"/>
        <property type="gene ID" value="Ngar_c23820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23820"/>
    <dbReference type="HOGENOM" id="CLU_1369568_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2380-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="21163" checksum="D50CA131469DC4EE" modified="2012-11-28" version="1">MNKPIITLVVLFVTASLAAAADVLAAIGAATIFAQSALAQTTTTTTSTTQENNTTSLAIHIQITKDATSSYAISEGSAQIGSFDTVYVITGLIDDISGNNNLITSTIQDDFNASSTAGYVMAQETTASSNNSTQTTTTTTLPNQFASSEEIRQRIADEIQKGIEAAERSEERYAEIRCNFGMDLPRFECMSIPLLGQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE0</accession>
    <name>K0ILE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60348">
        <property type="protein sequence ID" value="AFU60348"/>
        <property type="gene ID" value="Ngar_c34330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34330"/>
    <dbReference type="HOGENOM" id="CLU_1243077_0_0_2"/>
    <dbReference type="OMA" id="THPLVDY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3434-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="226" mass="25481" checksum="9F2E1682934C0123" modified="2012-11-28" version="1">MPLKAPCYIALAGLKDFGRLVCALERTPMPAFSLRFNKRDVLAAQTDIINGRPVIYYAESDSKDGQYLAYRVSNGVEEVLLASSVDNPTFVYSPILKVEKFPSALARSARVEKKSGYTVIKLKDLSSLAKVAAYKTIYDEPPLPLFLFKERGGKVILGTTMSVNDNETVSYFYYVTLAEEPKEPFLRYSSQRVEQPVFSVRLDEHGYVYLKVIRLAADHPLVKTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI6</accession>
    <name>K0ILI6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hsp20</name>
        <name evidence="1" type="ordered locus">Ngar_c25810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25810"/>
    <dbReference type="EnsemblBacteria" id="AFU59502">
        <property type="protein sequence ID" value="AFU59502"/>
        <property type="gene ID" value="Ngar_c25810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25810"/>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="147" mass="16164" checksum="52C15D9FAB874E8C" modified="2012-11-28" version="1">MGRKTAGESIFREFEEMRRDMERMFEETVRDIDRVPKDLIREYETPTGGRVREVGPLVYGYSVTIGPDGKPKGREFGNVRSLGGGVAVPALAAEREPLADVITTDKDVKVTIEMPGISKNDVKINAYDGAVEVSTTEAAPRKISSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK9</accession>
    <name>K0ILK9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59537">
        <property type="protein sequence ID" value="AFU59537"/>
        <property type="gene ID" value="Ngar_c26150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26150"/>
    <dbReference type="HOGENOM" id="CLU_1227690_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2615-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="24462" checksum="8E30186D77866ED2" modified="2012-11-28" version="1">MTAVFAAVGVGVSVGIIAAGGGFSAPGRPILTPPTAEDIWVVGGNIKDGTALDYSLTAKSEASSLDSAQVSMVFTEAGDDNWNVEFTIVNGTGQTVVENTMTMSKELTREGQLDESFRPYFDPIQSSIFAVREMEYGDSPKYLVVGAPWNQIFYQSSEVIVRVTGEETVQTQAGTFDAFVLSYKLADKTSKIWVVRDMPLPVKAEVYDPEDNLQYRYELVRASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW2</accession>
    <name>K0ILW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59727">
        <property type="protein sequence ID" value="AFU59727"/>
        <property type="gene ID" value="Ngar_c28070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28070"/>
    <dbReference type="HOGENOM" id="CLU_3338597_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2807-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4324" checksum="9E4A3F9DEDDBF624" modified="2012-11-28" version="1">MARNRRSNKQYDRNAAKDKSTDSNKNKKKGMARRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW9</accession>
    <name>K0ILW9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57409">
        <property type="protein sequence ID" value="AFU57409"/>
        <property type="gene ID" value="Ngar_c04650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04650"/>
    <dbReference type="HOGENOM" id="CLU_2730536_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-463-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7807" checksum="AF19AB7C1D6BAF8B" modified="2012-11-28" version="1">MLVQINPFLLLKPYGSAYYADGLQPAHALNQGYSVPIDIMIVNSPTQKVPTLSRNFGSWLTMPTGFGIRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILZ1</accession>
    <name>K0ILZ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57454">
        <property type="protein sequence ID" value="AFU57454"/>
        <property type="gene ID" value="Ngar_c05110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05110"/>
    <dbReference type="HOGENOM" id="CLU_153621_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-509-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12875" checksum="26D084127E999230" modified="2012-11-28" version="1">MPKLERYWKSSKRKAPDFTNFLNDLLADIVETERFQEIIAPRMIKLGLDQDNLNCMYIKDEKDNKIAEVFLNDNKLYCQLDKSHNCNHVMFALLQPEVSRLQIKKPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM54</accession>
    <name>K0IM54_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dys2</name>
        <name evidence="2" type="ordered locus">Ngar_c06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06260"/>
    <dbReference type="EnsemblBacteria" id="AFU57569">
        <property type="protein sequence ID" value="AFU57569"/>
        <property type="gene ID" value="Ngar_c06260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.603"/>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OMA" id="YTSSPGD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="356" mass="39613" checksum="E1874229BAA8BA9D" modified="2012-11-28" version="1">MDSRHTFTGRKIDPQKVSANMTVPDLIRFYGSTGYNARRLAEAAEILQDMIDTNSTVCLTLAGAMTPIGLGRTISEMIEKGFIDWIVATGANVYHDLHFAYDLPVRQGHFDVDDDILYAKQIVRIYDVYIKEMGTLQAQDLIVQKEIRRAKDMPPNASTADIAYALGKAAKENAKHPEKSFLVKAYEHKVPVYMPAISDSSIGLNMLPLLFEGKGVFPNVILDVAESAAILWKSDRSGGLELGGGVPKNFFQQTGPALYQILKIKEGGQDYLIQLTDARPDTGGLSGATLQEGKSWGKIKTSHRGNVIVYGDSSVYFPLLCSYAMSVCSPRKHKQLYEKKDAWVEEMKRTYFKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH9</accession>
    <name>K0IMH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57909">
        <property type="protein sequence ID" value="AFU57909"/>
        <property type="gene ID" value="Ngar_c09670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09670"/>
    <dbReference type="HOGENOM" id="CLU_1976603_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-965-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="14850" checksum="272CF49D7D52CB3E" modified="2012-11-28" version="1">MTRTDKKFYQFTRRQVKDILTYDVNGRVRYSKEDHLKLLLSACLVNGFAEGVSRSLNRSPTGETLLSYIKTQDREKLLQEFDRTVHKNVRMLRRRRKLTTPVPVAVDWHDIMYYGDPKETPMVIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK2</accession>
    <name>K0IMK2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c34470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34470"/>
    <dbReference type="EnsemblBacteria" id="AFU60362">
        <property type="protein sequence ID" value="AFU60362"/>
        <property type="gene ID" value="Ngar_c34470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3445"/>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_2"/>
    <dbReference type="OMA" id="DMNTRDT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3448-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="15"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="300" mass="33030" checksum="53BA33BE9D8ECDC7" modified="2012-11-28" version="1">MLTVFGTVALDTTRTPFRTETRILGGAATFASLSSSMFAQTSIVAVVGSDMPADHIRAIRSKGIDTKGIVTVQGGKTFHYDSSFDYDLSNRTTNKTELGVIAGFDPVIPEEYAKSDYVYLANNDPKQNIKILQHFQNPKLVVCDTIEFWINGSRDDVIKMVGMADGVVINDNEARLLCKEANIAKCAKKIMSWGSKFAIIKKGEHGAILFTSDNQVFPAAAFFLDEIVDPTGAGDSFAGGFLGHIARRNRSDFATMKEAVIYGNVMGSFAVEDFGVKRLLSITKDDVEERYKKYRNLVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK9</accession>
    <name>K0IMK9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Box A-binding protein</fullName>
            <shortName evidence="5">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA sequence-binding protein</fullName>
            <shortName evidence="5">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tbp</name>
        <name evidence="7" type="ordered locus">Ngar_c34620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34620"/>
    <dbReference type="EnsemblBacteria" id="AFU60377">
        <property type="protein sequence ID" value="AFU60377"/>
        <property type="gene ID" value="Ngar_c34620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34620"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3461"/>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20572" checksum="8C8A00B083CA79DA" modified="2012-11-28" version="1">MPQTKPIVSIENVVASATVNQTVNLNLITQIFPDVEYHPDQFPGLVFRLRSPKTATLIFSSGKMVCTGAKSEKMAIQAVKNVVLKLKKGGIPLEHEPQIEIQNIVASASLGGKIHLELAARVLPRSMYEPEQFPGLIHRMLDPKTVILLFASGKLVCTGAKKESEVYRAVGNLHTLLEEKNLMIYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML7</accession>
    <name>K0IML7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58004">
        <property type="protein sequence ID" value="AFU58004"/>
        <property type="gene ID" value="Ngar_c10620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10620"/>
    <dbReference type="HOGENOM" id="CLU_1324056_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1060-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="23471" checksum="F05921B5068D83F0" modified="2012-11-28" version="1">MYWFKQLGRYALLSLSVTLITISYWHEHPIRYEVLGFSPPFPRQEIGDDIRDGVNVNGVKLVQTRDEYGDALDNSTDIQRITYLSNGMNLNATLWLGANVGNSSSLNGIDAAVYGMLIDVDSNLQTGKEGVDYQMEIQWHNETENWNKVFVEYSSLGHLRVLDIGRNHTSSLVTDVPYAMLSLDLDDIGFPDGFKIMYYQYLAITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP7</accession>
    <name>K0IMP7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/ribitol dehydrogenase family protein</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11430"/>
    <dbReference type="EnsemblBacteria" id="AFU58084">
        <property type="protein sequence ID" value="AFU58084"/>
        <property type="gene ID" value="Ngar_c11430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1082"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_2"/>
    <dbReference type="OMA" id="FPQWGAY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1141-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="229" mass="24780" checksum="C72DBAC2E32D0D68" modified="2012-11-28" version="1">MATAIVTGSGRGIGRETAILLAKKGVNVVVCSRTQSEINNTVEAIKEIHLGVLGVKCDVSVSWQVDNLVKKAVEKFGPVDILVNNAGIFTVKKLVDTSEKEWDQILAVNLKGAFLCCKAVLPYMLDKNSGAIVNISSGAGKVGFDSLSAYCASKFGMMGLTESLSWEVAGHKIKVMAICPGEVATKMQEADPEYYKENRDRMLEPKQVAAKIVDMIFSDKYRNGQSVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX2</accession>
    <name>K0IMX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sodium/hydrogen exchange</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c14330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58369">
        <property type="protein sequence ID" value="AFU58369"/>
        <property type="gene ID" value="Ngar_c14330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14330"/>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="OMA" id="PAILMCF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1431-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="15"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="388" mass="40805" checksum="8FCE0ED095749D3F" modified="2012-11-28" version="1">MTVGIELVGDLGYLLLVCSAVGALAYVLKQPMVLGFLIAGILIGPFGPFSLIKDTEMLNNFSDIAIVLLLFGVGLSFPLGQLRAIGRIGTSIAVIEVLVMLAIGFAVGSALGWSFYDAMFLAAALSISSTAIIVKVLEDMGKMESMSAILMIGVLVIEDLVAILILSAMHAGVVSGSFAFTEIIVTMGEIGLFIGGTIGVGILVMPRIFALIAKLERYEITIMFALGTAFGLAFLSYELGFSAATGAFLAGVIIAGSKFSEQISVMISPIREIFTAIFFVTIGALMDLSLISVYWVPVAIITLVTIFGKFGAVYAGTRLMGFDKSFAIGIGLSMAQLGEFSFIVLKTGQDLGVISSMLFPIIGMAVALTTFIGPMLVKLGSRVVAVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN52</accession>
    <name>K0IN52_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD linked oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18360"/>
    <dbReference type="EnsemblBacteria" id="AFU58769">
        <property type="protein sequence ID" value="AFU58769"/>
        <property type="gene ID" value="Ngar_c18360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18360"/>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1834-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="507" mass="55484" checksum="61A4A4F8913A939B" modified="2012-11-28" version="1">MLIHACGKNLLYAYGYSLPLHHVIADDLLRIAKGEVLGDSWSRQAYSVDASHYEIQPAAAICPVDSHDVEQACKYSSEKKVPITARGAGTGLLGQSLSEGIILDFTKHMNRIIEIEDDYVVVQPGIVKGVLDRELKKRNKFLPPDPASSNYCTIGGMIADNSSGMHCLGYGNTIDFLEGVDVVYADGEPGFASADRFDGRMEKLGKLLSPHADAIKNGYPKVSKNSCGYRLDTVMSDRFMPHKVFAASEGTLGIVTCAKLRLLDIPEYRCIMVLGFVDLLGAVSAVPAILKFSPVALEMLDHTVLSFGSRAGGTGCLLFVEFAGDDSKKIEDRLQACKEELAGKCSVLEYASDEQSMAKIWRARKGALNNVMKLTVGSRKPIGLIEDTVVRPELLADHATNLLQTYRQNKLDYVMYGHVGDGNIHTRPLVDMGSDKEVDLMRRIAKSVFEQVIRSGGTITGEHGDGLARVSYIEMMYGRHITDLFSAVKKLLDPAFMMNPGKKVPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN72</accession>
    <name>K0IN72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA or RNA helicases of superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19370"/>
    <dbReference type="EnsemblBacteria" id="AFU58869">
        <property type="protein sequence ID" value="AFU58869"/>
        <property type="gene ID" value="Ngar_c19370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19370"/>
    <dbReference type="HOGENOM" id="CLU_2646046_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1935-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8499" checksum="F564079FD7C7DC91" modified="2012-11-28" version="1">MEISYDVPEAMIEIILATTWNMNQIVQRIGRVLRKADGKDSALVYLVYVSDTKDDGILALVRRAVETSGDAEDNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN81</accession>
    <name>K0IN81_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58914">
        <property type="protein sequence ID" value="AFU58914"/>
        <property type="gene ID" value="Ngar_c19820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19820"/>
    <dbReference type="HOGENOM" id="CLU_1559405_0_0_2"/>
    <dbReference type="OMA" id="WRLMGRT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1980-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="177" mass="18358" checksum="002EDE25A27C6811" modified="2012-11-28" version="1">MDTNGVMVDKTNKPQLLSAVLRRPFYALLSAVVAAGLGLLYYYLTVSAVPVSSALEMLGPLYVTTSIALTFAAAALAGINISLAIFRIKNAKLIAIRRSGSSAAFGSTLMAFAPGCPACTTPLLAVLGTAGGLTLFPLQGLEFKMISVAALTLSTYWMAKMPPHQNVCGVGDKVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN82</accession>
    <name>K0IN82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58919">
        <property type="protein sequence ID" value="AFU58919"/>
        <property type="gene ID" value="Ngar_c19870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19870"/>
    <dbReference type="HOGENOM" id="CLU_182718_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1985-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8781" checksum="D1F50E8EFC1618B2" modified="2012-11-28" version="1">MNEVFVEVTRKGCVMIPKAFREKHHIEGKALLVDTKEGVLIKSILDPLTEKGSLKKLFAGRTTKQLLREARFEEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN95</accession>
    <name>K0IN95_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58984">
        <property type="protein sequence ID" value="AFU58984"/>
        <property type="gene ID" value="Ngar_c20520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20520"/>
    <dbReference type="HOGENOM" id="CLU_2821040_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2050-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7966" checksum="9A41794CE2D83506" modified="2012-11-28" version="1">MMEELAKSPTDGVEENEIGETFIEWYTSTLIDYIYKMTIASVLFFITYPWAAFFWPPYYFMGRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF6</accession>
    <name>K0INF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59289">
        <property type="protein sequence ID" value="AFU59289"/>
        <property type="gene ID" value="Ngar_c23640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23640"/>
    <dbReference type="HOGENOM" id="CLU_2839487_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2362-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="65" mass="7111" checksum="C6EE50A5F573090C" modified="2012-11-28" version="1">MPKSNDFRKGGGSSSSDGIPHTAADFQCFVCGAVFTTDEDRKHHLEKEAHGDLRDDTTEGEMRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI9</accession>
    <name>K0INI9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c25310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59454">
        <property type="protein sequence ID" value="AFU59454"/>
        <property type="gene ID" value="Ngar_c25310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25310"/>
    <dbReference type="HOGENOM" id="CLU_2230467_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2530-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11793" checksum="5D9CD7AF5DDB2419" modified="2012-11-28" version="1">MVDAQRRQVIQNTLNVRAHAKKIKKPLLNLARKKKGSKNREKTRKRGGQVIVVNPNGTSQKCSRCGVVAEKKLGLDVRMFECYSCGMVIDRDLNAAKNILKLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ0</accession>
    <name>K0INJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59459">
        <property type="protein sequence ID" value="AFU59459"/>
        <property type="gene ID" value="Ngar_c25370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25370"/>
    <dbReference type="HOGENOM" id="CLU_707136_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2536-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="383" mass="41064" checksum="56450B08249F7EF1" modified="2012-11-28" version="1">MLVFGASSVALSGSAYAQQDDLWYPGEGVRQDMYVTYRIQELDTADGDPYVMTLYFKEQQDGDWIVPAAVQHGNNVITGIMKLSDGMSYLAGGSQVPAEMNDFIGGYQGSLHWLDAFTTKSAPLSLTAGSWGKIAAIGGEEIRPRGVEKVAFEGAQDLCQADSCDATLVMWHKGVDNKIWIVNGFPFPVRADTFAEDATGSEVTQFRFELLETGTGEPPGLSGSGAAQKPPIEKRTHSGYYIRLEWTPEEIQPNNDVSLGISMFDAQKFPLLDVRYDLTIKDSSGQVIQELKNQVAELGTATHQVNFNGTGTMMVTVTITAFGGQTTGQFVEGADFGIVVVPEFPVSAAMVAAAVIGLVVIITRTRGTSIGSSLFGNKGTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK0</accession>
    <name>K0INK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly-beta-hydroxybutyrate polymerase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phaC2</name>
        <name evidence="2" type="ordered locus">Ngar_c25870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25870"/>
    <dbReference type="EnsemblBacteria" id="AFU59509">
        <property type="protein sequence ID" value="AFU59509"/>
        <property type="gene ID" value="Ngar_c25870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25870"/>
    <dbReference type="HOGENOM" id="CLU_035017_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="491" mass="56359" checksum="D47A1AD2F56A872E" modified="2012-11-28" version="1">MPVQMSFFLPLTSINAYLHGIAIANIYNLVYFRAFERAVAEQQVEYIVESQKMYSKNGREARSTINIFETFYSSWLRNVDDELKNELKSDSFAELLSKYIQDLLNLRSEFKKAGYPMDYLDRLFELFKQGQSAFFFQTAKESNLAPFDVAYRKDKSRLLHYRYEDKAEGSNFGADSDTKKKVRKRQPQPLLIIYAPINTFHILDLNPRKSVVRNLLSPGGLDIYLLDWGYPDSTDDHLSVEDYLRYIDDSVKIIKEQTGADKVSLMGYCWGGIFALIYSSLNNDNVRNLVLMAVPVDFSKDDTILTKWSKAVDIDRMMNELGRMDGQMLDLAFLMRNPPRYGFDKYMKSFQKMFDNEFVQTFIDVERWLYDTPPIPGALHRQIITDCYINNLLVSHRMQVGGKNTATGGGSKQQSTILAAVDLSKITMPVLTIIAEKDDLVSRASSLAINDHTSSKDKSVFQYPGGHVALCISDTAHKKLWPDVARWFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ8</accession>
    <name>K0INQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28800"/>
    <dbReference type="EnsemblBacteria" id="AFU59799">
        <property type="protein sequence ID" value="AFU59799"/>
        <property type="gene ID" value="Ngar_c28800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28800"/>
    <dbReference type="HOGENOM" id="CLU_085858_3_0_2"/>
    <dbReference type="OMA" id="RKGGIHE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2880-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014923">
        <property type="entry name" value="DUF1802"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008307">
        <property type="entry name" value="UCP018957"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08819">
        <property type="entry name" value="DUF1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018957">
        <property type="entry name" value="UCP018957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="20995" checksum="82A1C53E047095B6" modified="2012-11-28" version="1">MQALKEWAVVCRALEEGRQVVLLRKGGILEYRQGFEVKHDKFLLFPTFEHQSKDHLQPDYAAKLDEILKEQPAAGSNRITAYAQVVEVKEVSNRTALHSLAKYHVWNESYVNARMDYNPKKPMSVILLRVFKLDQPIMVDSRPEWAGCKSWIPLDMDASGRPVLDDLQFEKLASEVKGVLSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP30</accession>
    <name>K0IP30_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34960"/>
    <dbReference type="EnsemblBacteria" id="AFU60409">
        <property type="protein sequence ID" value="AFU60409"/>
        <property type="gene ID" value="Ngar_c34960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34960"/>
    <dbReference type="HOGENOM" id="CLU_097806_0_0_2"/>
    <dbReference type="OMA" id="MNLRRDV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3497-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="12362" checksum="275D947D80F04489" modified="2012-11-28" version="1">MGSPWKAIADDNRRQVLLLLKDKERTPSEIATHFDFTLPALSTHLKVLRDAGLVNERREGQNRYYSVNRDAMSEMMRFFDLFWDDRLKSLKEYVENKERKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP47</accession>
    <name>K0IP47_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative arsenite methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.137</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.137" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35810"/>
    <dbReference type="EnsemblBacteria" id="AFU60494">
        <property type="protein sequence ID" value="AFU60494"/>
        <property type="gene ID" value="Ngar_c35810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3588"/>
    <dbReference type="HOGENOM" id="CLU_052868_1_1_2"/>
    <dbReference type="OMA" id="RGSYVGC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3582-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="78"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="254" mass="27095" checksum="575F97320B7FE026" modified="2012-11-28" version="1">MEKRRQQNIKQTIRRNYGKIALEQSGEGACCAPGCCSGPSPAKAAADVGYDTGELESVPKASIIGAGCGAPVKFANLQKGKVVVDLGSGAGIDVFLSANKVGGSGRVIGIDMTDEMLERARRNAKENGYANVEFRKGDIEERIPVDGGSADVVISNCVINLTTDKVRTFKEIHRILKDGGRMVISDLVADRKAGSINLERWSSCIDGAMAKDDYVANIKKAGFKDASILEEREFMGGELIGGRKITSLVVRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6W2</accession>
    <name>K0I6W2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56991">
        <property type="protein sequence ID" value="AFU56991"/>
        <property type="gene ID" value="Ngar_c00410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00410"/>
    <dbReference type="HOGENOM" id="CLU_2010156_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-41-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="14002" checksum="5E58E8A78BB90E88" modified="2012-11-28" version="1">MYSPLLHKFVMNEKIAGESGLEYSFDVGIYGRSSEKLVAVGMQNNDKAQQPADTNSLHKFLAAIKDLRAVHPDMQGAYYSSSYGYQDDSAWHLARRHGEGADKTEIRFFDYKDKIYFEIKSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7T4</accession>
    <name>K0I7T4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">Ngar_c03780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03780"/>
    <dbReference type="EnsemblBacteria" id="AFU57326">
        <property type="protein sequence ID" value="AFU57326"/>
        <property type="gene ID" value="Ngar_c03780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.364"/>
    <dbReference type="HOGENOM" id="CLU_052779_0_0_2"/>
    <dbReference type="OMA" id="YYVGSFY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="345" mass="39290" checksum="2B4CE282DA5D4AF2" modified="2012-11-28" version="1">MLSEFGLFLGRKRNRYVVKNGNAKNEILSTDVEQLHILNPGVSLSTSALRLALSNQTLVVLGSRNGWPHGFVIPAKISGTIRAKREQFLAYHDFRGAVLAKKFASGKSFNQRNLLKLLWKNRVKTEPGLAEKMYKASEEVERLAREIDSIEGSSVDKIRTDVMNREARASKEYWDAVSNLFPPELKFPGRKTRGATDPVNAMLNFGYKAILFVECWKAVYYSGLDPYAGYLHADRPGKPSLALDLMEEFRQHVVDRVLFTIFSKKMLKIDEIMQFDEVKNQQRLSKQTIQVLIGEITGQLESEVAYGRNSGERCLMKNVIQNQSRALVSYLMNPSKEYDPFELAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8A8</accession>
    <name>K0I8A8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05630"/>
    <dbReference type="EnsemblBacteria" id="AFU57506">
        <property type="protein sequence ID" value="AFU57506"/>
        <property type="gene ID" value="Ngar_c05630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05630"/>
    <dbReference type="HOGENOM" id="CLU_714958_0_0_2"/>
    <dbReference type="OMA" id="ASEIAYY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-561-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="396" mass="43544" checksum="5E562DB05D5FA61D" modified="2012-11-28" version="1">MDVLTTTDSNNNSSDLPDSLEEFGLSKYEARAYLTMIGKGSLAASEIAYYANLPRTKIYQTVKKLEKKRLAVVSKQKPLICSAIPPEEAFAEIVNLHERRVKNMKKIVDRLQKINDEGQRPKGSEERRYFILDANSALEKLGSLIAGSRSSITATLDQWGLRLISQCRPSLVRAVTAGVRARFILGQQCIGSESIFQLPEGIELRTGDAAINVIIIDSTHMVSVDSSNGKAALFSSTDSFGALQSKNFEEAWSRAGEVKYLLDTEPAVAAKAVELARIVENGLSLRMLEYAVGGADMMPAELVQDIEERYGLKISDMSAAEVMDLVDSALKISCLGGLKHDRSNNIVSLQSKVDSKHVLPWALVLGSYFRRAGNEPRIMQQGKSAQLVHLRLSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8D2</accession>
    <name>K0I8D2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57536">
        <property type="protein sequence ID" value="AFU57536"/>
        <property type="gene ID" value="Ngar_c05930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05930"/>
    <dbReference type="HOGENOM" id="CLU_2712959_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-591-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8293" checksum="227F053A09195BA1" modified="2012-11-28" version="1">MFGGRRKGCKRGWGAEGKKTLVFGIYRRRNGKVITFPVSDRRKEKTLIPLIRQHTGKGSLYIIQTTILHMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9B5</accession>
    <name>K0I9B5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09840"/>
    <dbReference type="EnsemblBacteria" id="AFU57926">
        <property type="protein sequence ID" value="AFU57926"/>
        <property type="gene ID" value="Ngar_c09840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09840"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.937"/>
    <dbReference type="HOGENOM" id="CLU_078518_3_2_2"/>
    <dbReference type="OMA" id="MEIERTA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-982-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="220" mass="25261" checksum="B39FFE5FA31FDB09" modified="2012-11-28" version="1">MTRLLDLGIDRIRNLIMDMSEISERSVITAIESYEKGSSVKKTIFNWSEQLRVLQDEVSDLAIELIARYQPVATDLRFIRSCMEIAYGFSRFGRYAYDIVDVLETMGSVGECDKSAVLEMSSTAREMIRMSVLALRSKDKDAAQQLYKMDDTVDALYRKYLREALTPPHSTANKDKRFVDPRCYISALLILRYLERIADHACYIADSVHYIVTGESSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9R9</accession>
    <name>K0I9R9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58071">
        <property type="protein sequence ID" value="AFU58071"/>
        <property type="gene ID" value="Ngar_c11290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11290"/>
    <dbReference type="HOGENOM" id="CLU_1313166_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1127-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="209" mass="24240" checksum="256640E4A58D442D" modified="2012-11-28" version="1">MNIDLHTGARAFAMASMSLDRIAMSPAFRVEQFEPKIKKGSWFLTREGKWWVKYPTEECRAIVETAQDRLPKDRSFVFFDDAKSDRANCLRAGYFAKRMAVRFRKLFSELDKRSWLNEKTRIYALGDGLYFDGKPIHLFRHTMAQYYLAVTNWSLAYVASLGGWENTEILNKCYGGIPEHIKAQIARSLHVKFDTMNLNTAAMIQSIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA12</accession>
    <name>K0IA12_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58161">
        <property type="protein sequence ID" value="AFU58161"/>
        <property type="gene ID" value="Ngar_c12210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12210"/>
    <dbReference type="HOGENOM" id="CLU_1709038_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1219-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="157" mass="17384" checksum="3D2C0B81D595E708" modified="2012-11-28" version="1">MGQQDYSAYSEQRAQERLQMIDTLKAPIIQMGRDLGYEVIENHDLGAGPVHVAWVFKPGSESLPDMRLGFICLTEFSHSSINEGIARAMLNLIDKLVFVVPTETMTSQVKEAIESMPDKSILQLRKYVTVLTPSTLVSKTGVQGARERDSVQTGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAG7</accession>
    <name>K0IAG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58306">
        <property type="protein sequence ID" value="AFU58306"/>
        <property type="gene ID" value="Ngar_c13680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13680"/>
    <dbReference type="HOGENOM" id="CLU_2821038_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1366-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7726" checksum="0ED8466658668D86" modified="2012-11-28" version="1">MDILGEPSRNMIIIYIQKKYNVSIFSDISRSVSIEEIEDTIQELFPIGSELIIKMFEAEIDRMESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBQ0</accession>
    <name>K0IBQ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps14p</name>
        <name evidence="3" type="synonym">rps14</name>
        <name evidence="4" type="ordered locus">Ngar_c17430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17430"/>
    <dbReference type="EnsemblBacteria" id="AFU58676">
        <property type="protein sequence ID" value="AFU58676"/>
        <property type="gene ID" value="Ngar_c17430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17430"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1717"/>
    <dbReference type="HOGENOM" id="CLU_177289_2_2_2"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="PTHR12010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="59" mass="6931" checksum="7F2E0D98595E3143" modified="2012-11-28" version="1">MPKPREYEVTGRKKLAHGKGTRWCKRCGSYNGLIRSYNLMLCRQCFREVANSIGFVKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBT9</accession>
    <name>K0IBT9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG2</name>
        <name evidence="1" type="ordered locus">Ngar_c18080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18080"/>
    <dbReference type="EnsemblBacteria" id="AFU58741">
        <property type="protein sequence ID" value="AFU58741"/>
        <property type="gene ID" value="Ngar_c18080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18080"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="OMA" id="VYLCCKA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="251" mass="26891" checksum="4E9E26A008574E48" modified="2012-11-28" version="1">MLLLKNKVAVVTGASGGIGFQIAKEYAARGATVIVCSRKIASAEKTANMIKGKAYPERLDVTDAPGVTKFVRHVAERHGRIDILINNAGYPFDRNMWTKRFHEVAEEEFDRVIEVDLKGTLRLCLSALPFMIKGGGGVIINISSTPAVSGHTEGAPYTVAKAGVIAITKHIALEYGDKNVRAYTLALGNISSEATFNSMTVTERKKAAMENSMKRWGDPSEVAKVAASLASDDFSFATGNTIVIDGGTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICM1</accession>
    <name>K0ICM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59116">
        <property type="protein sequence ID" value="AFU59116"/>
        <property type="gene ID" value="Ngar_c21860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21860"/>
    <dbReference type="HOGENOM" id="CLU_2911654_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2184-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="7033" checksum="4EB4643B9DB27C10" modified="2012-11-28" version="1">MVVWCVLIHVKHYKLIVGRDTGRMTTKKQAGVQKLVASKKTAEELAIEEYQRQLELAIENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICQ9</accession>
    <name>K0ICQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57430">
        <property type="protein sequence ID" value="AFU57430"/>
        <property type="gene ID" value="Ngar_c04860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04860"/>
    <dbReference type="HOGENOM" id="CLU_1363691_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-484-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="200" mass="21548" checksum="F5A00C553DF4E3C9" modified="2012-11-28" version="1">MNWTSYASLVSAILLGAIFAAPSASAYFYSQTPESRLSSECGETGCFYDVTVEGNTFSVQYDIANDRGTPDSRTAQITEIVVDTGKKALVIDLNATYWGILYINVPRSLLDASDGGQDTEYTVFVNGQDVSDNVIEITKYVNNNAGDGNRVLSISYSQGQKQIEIIGTQIAPEFGPITAMIMGAAISGIIGVTIFARRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICZ3</accession>
    <name>K0ICZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57535">
        <property type="protein sequence ID" value="AFU57535"/>
        <property type="gene ID" value="Ngar_c05920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05920"/>
    <dbReference type="HOGENOM" id="CLU_677267_0_0_2"/>
    <dbReference type="OMA" id="DEIANCA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-590-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="393" mass="45958" checksum="EDD2FEF6DA1B7CE8" modified="2012-11-28" version="1">MGIIGNMANNGYNTAKALRKFGMDVDLIITSSVLNPFAAVEWEEGIFGPEISQDNFSFETVVAAGKLWDRPKWVKYYDTWLFKNRQTLFKRWFEGLQFYDIIADYDILELHVPFPIMSPFFKVPTLVYEAGWIREFPRGNTYSDFLACRGYAKADRILVTNIDMWRIFDSLDYIGKDRVLYMPFSIDYERYCPMDMIELRRKVAKDNEIILLNPSRQHWEYKGNDKVFKALKKLSTEYDNVKLWAAEWGKDLSKSKSLIQELGLVDKVLWFPPVAKPKLIEYFNAADIILDQFAEPSDKHQIWGPWGTAALEAMSCGRPLLMYYDLEGVDRYVGEKPYAVHSLSIEDIYRNLKMLIESPSFREEVGKKSREWVKRMHGPEVVARKYQQLISVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID05</accession>
    <name>K0ID05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57545">
        <property type="protein sequence ID" value="AFU57545"/>
        <property type="gene ID" value="Ngar_c06020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06020"/>
    <dbReference type="HOGENOM" id="CLU_2392982_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-600-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10471" checksum="2548EC26C737961E" modified="2012-11-28" version="1">MKTRDRNDDKINNDVTASPFPTSSEPELEAIVGETYVADFQSHRLKTALSDKVAGYMHLGSGYYRRNKKSSSSTGVFSHRGKLYRISISVREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV7</accession>
    <name>K0IDV7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59566">
        <property type="protein sequence ID" value="AFU59566"/>
        <property type="gene ID" value="Ngar_c26440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26440"/>
    <dbReference type="HOGENOM" id="CLU_153630_0_0_2"/>
    <dbReference type="OMA" id="REFMIDG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2644-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="14709" checksum="F0F1B54C62EF5209" modified="2012-11-28" version="1">MEFIDGDGNIIVPKAVRPIIDLEETILGSKKGAKRQYRYGKLHIRDYDTHYTVHMDKVDPRSSPLGHLLVDAPEYLAGAAAAVIVGRRVGAAVYSRCKKEGKSTSDAAIDAALAGYLAGSSAGNIIANAAGLLKKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDY0</accession>
    <name>K0IDY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC efflux transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c26650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26650"/>
    <dbReference type="EnsemblBacteria" id="AFU59586">
        <property type="protein sequence ID" value="AFU59586"/>
        <property type="gene ID" value="Ngar_c26650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2640"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="TFCARMY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2665-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="317" mass="35232" checksum="FC6DCBFF9C1BB6D0" modified="2012-11-28" version="1">MEEPCVHVSDLRKSYGSVQAVDGVSFDIEYGRVFGFLGPNGAGKTTTIKVLTTLVHPTSGTVKIFGKDIVKHQKEIKKKIGVVLQEPSFEANLTVERALELYGLMWGVPSEKRRDRARELLDKFDLASFKGMKNDELSIGQRRRVQVAREFMHDMDLLFLDEPTVGLDPAARRILLDYVKKHVKGGLTVFFTTHIMEEAEYLCDEIAIINRGKIIATDTPAGLKQKYGGVKAVEIKLRDSSAQSVMHIIRPIAGSSSIIETPAESMIRISSADAQEMLMKIIESLSKDAVQIESVSVNPPTLEEVFLAVIDKEEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE13</accession>
    <name>K0IE13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26850"/>
    <dbReference type="EnsemblBacteria" id="AFU59606">
        <property type="protein sequence ID" value="AFU59606"/>
        <property type="gene ID" value="Ngar_c26850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26850"/>
    <dbReference type="HOGENOM" id="CLU_929435_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2685-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="299" mass="32826" checksum="187F59BB348DB528" modified="2012-11-28" version="1">MRRVTVGIPAYNEERNIVNLLRSLEGQQPLISEVIISDDSSDRTPDLVREFAKSSPLAITLLHHETRRGAAEAWNEILYKAASDVIVFYDADTIPHPSCTEQLALRISGNMALCASNSQPVQAAGVAGRASVFISNWLRSIRQSGLSQYTVMGRALAINASTAKKIQIPSDMIAIDLYLQCRILEMGLDVAYNDDAVVYFKPPSSMQDLASQVVRAVNGHNQIKDMVSRLGIGLPSHVAIAQALKNAAMDPIGAASTVIGYSLMPYYMSRLKHTDSAKWHTADSSKTIDYQQLKVRYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE52</accession>
    <name>K0IE52_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rps2p</name>
        <name evidence="5" type="synonym">rps2</name>
        <name evidence="8" type="ordered locus">Ngar_c11130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11130"/>
    <dbReference type="EnsemblBacteria" id="AFU58055">
        <property type="protein sequence ID" value="AFU58055"/>
        <property type="gene ID" value="Ngar_c11130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1055"/>
    <dbReference type="HOGENOM" id="CLU_058171_3_0_2"/>
    <dbReference type="OMA" id="QQKTKDM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="243" mass="26339" checksum="F0006B8B2D9DC644" modified="2012-11-28" version="1">MSNPKDRPDDIDDKTSAGIDEEAPLSDSAPVETQEGQEAIDTDNLEKMILSTGIRVGTPVKTKFMAPFIVKANPEGLYILDISKTLARVDVAAKFIGRANISKVAVTSAREYGKTPVEKFCELTGATQILGRFMPGTFTNPSLPNYMEPEIVVVTDPQADQQAVLEATRAGVPVIAIANSDNVTSKVDLVIPANNRGRKALATVYWLLAREVLKKQGAIKSDSEMLEKASIDDFETKLVEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE74</accession>
    <name>K0IE74_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58080">
        <property type="protein sequence ID" value="AFU58080"/>
        <property type="gene ID" value="Ngar_c11390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11390"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1137-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="12981" checksum="69821E79E19E458F" modified="2012-11-28" version="1">MSSYYEPRTERHRSKVDIVYDILASAMGGGAKKTHILYKANISSTQVESYFSALLAHNLLEKAQDFEGNNVYRTTGKGMQFIECCEQMRSLIGLVMNNRRIDPISDFYAFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE94</accession>
    <name>K0IE94_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57128">
        <property type="protein sequence ID" value="AFU57128"/>
        <property type="gene ID" value="Ngar_c01790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01790"/>
    <dbReference type="HOGENOM" id="CLU_154322_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-179-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12895" checksum="5B15EB398D9DE9CB" modified="2012-11-28" version="1">MVNVHYYYIPIGKVEGWDGNVLWLKVPEEYVKRNYERDTYPDPSQYYLKDFPGYTAVYPEVEVILPKYSRPVYTTKNTTPEEFRVNLCELCQTAFDTEDDLSQHVSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEA5</accession>
    <name>K0IEA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative biotin/lipoyl attachment domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01890"/>
    <dbReference type="EnsemblBacteria" id="AFU57138">
        <property type="protein sequence ID" value="AFU57138"/>
        <property type="gene ID" value="Ngar_c01890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01890"/>
    <dbReference type="HOGENOM" id="CLU_016733_5_1_2"/>
    <dbReference type="OMA" id="ESMKMQV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-189-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="170" mass="18217" checksum="221D175BE71D79FD" modified="2012-11-28" version="1">MEFKVGDLAEMLEGEVLRTTDNNSVLVRIAGKQHALRLLKAGTNEFEFVLDNTFHHAKILQSGSAEVKLVLDGQPLTVKKHSKLTEVLEKASALSGAGGGDRNLTSQIPGRVVNIAAKAGTEVKKGDVIVVLESMKMQVAVKAHKDGNLKEIKVKQGASVARNDVLAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IED6</accession>
    <name>K0IED6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59691">
        <property type="protein sequence ID" value="AFU59691"/>
        <property type="gene ID" value="Ngar_c27700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27700"/>
    <dbReference type="HOGENOM" id="CLU_2490573_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2770-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="10021" checksum="CEA63549BAE2FEE4" modified="2012-11-28" version="1">MTTSALIEDFQRAIAVCKGRDILIIAQSQDHANEHLRTLNAMIINSVRYSRYLITEPAEMLFREEKTKVKVAYIYNPDNPRRPTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEI7</accession>
    <name>K0IEI7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57178">
        <property type="protein sequence ID" value="AFU57178"/>
        <property type="gene ID" value="Ngar_c02300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02300"/>
    <dbReference type="HOGENOM" id="CLU_2784231_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-230-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7730" checksum="6192C29F08190E5C" modified="2012-11-28" version="1">MVKFYTSKEQALIDILKAHPNSTVSEMKMHIGLRNRNDVPHALNGLRVKGVLLHTADKPPRYSFSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEM7</accession>
    <name>K0IEM7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative electron transfer flavoprotein, subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">etfB1</name>
        <name evidence="1" type="ordered locus">Ngar_c12650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12650"/>
    <dbReference type="EnsemblBacteria" id="AFU58205">
        <property type="protein sequence ID" value="AFU58205"/>
        <property type="gene ID" value="Ngar_c12650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1211"/>
    <dbReference type="HOGENOM" id="CLU_1197666_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="231" mass="27183" checksum="55651C4C4DF5FBBB" modified="2012-11-28" version="1">MDELDIPRVSKHEFLAFLQNEAKVRVDNYIEGAIEVAEEVHSDLMREDGTSPFLETHTWPVTMDVVRHYRSVNRNITSVEIVAAILHDVMEDDDRILNLHESKSYGFEAYLAYRFGNRIRDIATELKIKPLENYPGSNDIERQMARFYEYCDILRDAEYDIKAIKLADRLNNMLFIRRVPGHDKVRRYTREAEDFYLAYPMLPPKMPEFYKRMREAYEALKVAPAKKLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEN4</accession>
    <name>K0IEN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58215">
        <property type="protein sequence ID" value="AFU58215"/>
        <property type="gene ID" value="Ngar_c12750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12750"/>
    <dbReference type="HOGENOM" id="CLU_2857223_0_0_2"/>
    <dbReference type="OMA" id="CEICKFP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1273-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6467" checksum="A30F96B31048E87A" modified="2012-11-28" version="1">MISCGCRCIVCKSQQLTSHSFVAPDGYDDIHHTCKSCGTHFNHLDGETYAKCEICKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEX9</accession>
    <name>K0IEX9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57353">
        <property type="protein sequence ID" value="AFU57353"/>
        <property type="gene ID" value="Ngar_c04060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04060"/>
    <dbReference type="HOGENOM" id="CLU_3021087_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-405-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6419" checksum="4B4128B0F115C516" modified="2012-11-28" version="1">MSVSTSASEKPLLEDSTYDIIHQLEKKADFLYSIVEKYVHDAEKDGKPELVTWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF20</accession>
    <name>K0IF20_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59956">
        <property type="protein sequence ID" value="AFU59956"/>
        <property type="gene ID" value="Ngar_c30400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30400"/>
    <dbReference type="HOGENOM" id="CLU_182706_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3040-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="8072" checksum="7B49A361C65C08D8" modified="2012-11-28" version="1">MEIRCNICDEIISTSAVEQHVAGRNHAIKKKVAEFHEMNVQVKASCQNDTSVIKAWIKDLYNYDFLSTGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFB3</accession>
    <name>K0IFB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC efflux transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c15610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15610"/>
    <dbReference type="EnsemblBacteria" id="AFU58495">
        <property type="protein sequence ID" value="AFU58495"/>
        <property type="gene ID" value="Ngar_c15610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15610"/>
    <dbReference type="HOGENOM" id="CLU_096331_0_0_2"/>
    <dbReference type="OMA" id="AWINGWI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1559-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="251" mass="27363" checksum="0A29EC2FAFAEEC1B" modified="2012-11-28" version="1">MAEASMMLPVRQAFLIAYMTGVLWLRRNPMSLVFTAISPFSLLFVLFVISGGQYTDFAVAGSLVMALVGYGLALGQDISFYKTEYKVQDVFVASPVSPLTYMMGLALSELLFGLPALVVLASLVIFFGAPIFSIPLLVATILLIWGSMSAIGFFLSSHMLHMRNATQVISFVNVILAILPPVFYPIDIMPPALQPLAYAMPTTHASLIIQYIIGMDTLPEGWSLGFGFTVLIAYLVGFVALAKTKAIWRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFG1</accession>
    <name>K0IFG1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpA</name>
        <name evidence="15" type="ordered locus">Ngar_c31900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31900"/>
    <dbReference type="EnsemblBacteria" id="AFU60106">
        <property type="protein sequence ID" value="AFU60106"/>
        <property type="gene ID" value="Ngar_c31900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3174"/>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_2"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="14">
        <location>
            <begin position="228"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="236"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFU60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="603" mass="66113" checksum="5AF2B5B6D0892EBD" modified="2012-11-28" version="1">MVAVAKGRIVWVSGPAVKADGMSAAKMYETVEVGESKLIGEVIRLTGDVAFIQVYESTSGLKPGEPVVGTGQPLSVLLGPGIIGRIYDGIQRPLDEIAAKSGAFIGRGVVTTPVDMKKKYKFKPVAKKGDQVGPGSILGTVEETPLLTHSILVPPNSPSGKLVDIAGEGDYDIEHVIATTEKGGEKVSLKMYHKWPVRKPRPYAERYDPTVPLVTGQRVIDTYFPIAKGGTGAIPGGFGTGKTVTLHQIAKWADSKVVVYIGCGERGNEMTEVLVEFPHLIDPRSGRPLMERTVLVANTSNMPVAAREASIYTGVTMAEYYRDMGYDVVLVADSTSRWAEALREMSGRLEEMPAEEGYPSYLASRLAEFYERAGRVKALGSPNRAGSVTLVGAVSPSGADFTEPVTTHTIRFIKTFWALDTRLAYSRHYPSINWMQSYSGYLEDVSKWWKENVTGEWYDLRAESYHVLQREDTLKEIVRLLGPEALPDEEKLVLEVARMVKIGILQQNSFDKVDTYCSPQKQVKLVKLMVKFYREAQKALKAGTPLADIRAMPIIPALLKAKFEIPEEQLSKLDDLDKQIDDQFRKAVGGAAAVAAEEAKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFG5</accession>
    <name>K0IFG5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF608 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06300"/>
    <dbReference type="EnsemblBacteria" id="AFU57573">
        <property type="protein sequence ID" value="AFU57573"/>
        <property type="gene ID" value="Ngar_c06300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06300"/>
    <dbReference type="HOGENOM" id="CLU_591361_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-628-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF608" evidence="1">
        <location>
            <begin position="176"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="455" mass="51481" checksum="927CA8DAFE3F6745" modified="2012-11-28" version="1">MVNSSDLADALNPFVSKAERFMETTEDYIRQGINPGGYYKAIWCRDASYILRDWFLAGHAEAVMRELMFIWSHQIAAGREKIIYGRGSPEMRYLSQVATSETEKRFEGALPTTIFHGFSEVYGQDPDIDSTALMISATSWILNAYLKAGLVSAPQLSYITESLEARISRTVSDPSTVIDFVLPRMLKGVDYLVGRDIDGDGLLEQGHNEDWMDTVLRSGKIVYSQACWILALSNLSSLLAELGKDEDANRIMALANRSVKAVEEKLWLEEEGTYIDLQEEHHIGGPYKTLTQDVVFYMIAVTENTTSDILSVHKDRKKEPASPEFTKHASSTLDAIKARIWKEKWPLVTEVELKTTGPWVLHPNEYHNHTFWPWITGAEMLARSRLRRFEECDHLLSILIQGEHSDNNSMLAFYEWVDSITGRGNGAFPFRTGISSIRLAIIDILANMQRTISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFK6</accession>
    <name>K0IFK6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c32300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32300"/>
    <dbReference type="EnsemblBacteria" id="AFU60146">
        <property type="protein sequence ID" value="AFU60146"/>
        <property type="gene ID" value="Ngar_c32300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3221"/>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="VYTGNPF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3230-MON"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="20569" checksum="B295187A83497B7C" modified="2012-11-28" version="1">MTTTSSRGLMAGRFQPFHSGHLALAKQILEECDELVVVIGSAQFNFIDKDPFTAGERVLMIHEALKETGIDLAKCYVIPVPNDENNARWIAYLRSMVPSFDVLYSGNDFVKHLVLSQDPRLAVKSPKFAKKEEYNGTNIRRLMLAGGQWKRLVPPAVARVIEQVNGIERMRVLAGSDSNPQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFY5</accession>
    <name>K0IFY5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60311">
        <property type="protein sequence ID" value="AFU60311"/>
        <property type="gene ID" value="Ngar_c33960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33960"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3397-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="185" mass="21221" checksum="A4D735335E00EB87" modified="2012-11-28" version="1">MTSGKFFNKGVMALDAPHIGYVVRETKDKIVIFGDGDERYDVLKSEIQMVSRNVLIGLPFHEIVRRYKKSRSHPLPISKPAAKWVFTHDVDLATYEKKYPKSLFNKGVRTKDEEHVGHVMKETDKKIVVWGHYDWRFDVPKSKIVAVGRNVILDMEYSEIFKYKVDRNSPLPTGEPVASLAAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG46</accession>
    <name>K0IG46_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58760">
        <property type="protein sequence ID" value="AFU58760"/>
        <property type="gene ID" value="Ngar_c18270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18270"/>
    <dbReference type="HOGENOM" id="CLU_3194628_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1825-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="45" mass="5205" checksum="B2B2D4C290CCDDDA" modified="2012-11-28" version="1">MMQRETDISPLQRAVNIYEVMKNEPIAECNILTQQQLSLPLAFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG75</accession>
    <name>K0IG75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58790">
        <property type="protein sequence ID" value="AFU58790"/>
        <property type="gene ID" value="Ngar_c18580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18580"/>
    <dbReference type="HOGENOM" id="CLU_128582_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1856-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="124" mass="14324" checksum="FC8DB1C269710B11" modified="2012-11-28" version="1">MQRNLCDKIIKLDRNIRFVGIVNNRGEVIEGGFQQGIEPLLDETAEQQMYIQSLWNLTTLESYSDKLGKVRYSITEHDKVTLMTFPLGDGILCLSVTPRANVNRIRDRVMQTIKKKPTSRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG82</accession>
    <name>K0IG82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase, IS605 OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c08860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57828">
        <property type="protein sequence ID" value="AFU57828"/>
        <property type="gene ID" value="Ngar_c08860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08860"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="SYHCVGI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-884-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="350" mass="41003" checksum="A858BD85DF46A3A9" modified="2012-11-28" version="1">MGVHNYFLDKNMSEYDMNYALTELKEQHPWLRKYYHSKMLQMVTHQVAAARKTATGKLKYRKDSDFNSFTYNQSGFKIEEDGKLYLSKIGRIRIVLHRQPVNVKQVTVCRKNGKWYADVACETLRRSFSTIIRYVKPPVGIDVGITKFCHDSDNHVVEDNPQFLTKMLKPLRKAHRRVSRRQIGSNNREKAKHMLARLYERIHNKRHDFLHKKSAYYASHYDLIFLERLKVLNLTKNHRLARKILDASWSAFKNMLLQYKANRVVEVEPAHTSINCSRCGYPVPKSLAVRTHVCTECGAVLDRDYNASLNILKRGLESLMMLPVERREVTPVEIAMQSRKQEEAHVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGD2</accession>
    <name>K0IGD2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin kinase</fullName>
            <ecNumber evidence="6">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">rfk</name>
        <name evidence="19" type="ordered locus">Ngar_c19280</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19280"/>
    <dbReference type="EnsemblBacteria" id="AFU58860">
        <property type="protein sequence ID" value="AFU58860"/>
        <property type="gene ID" value="Ngar_c19280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19280"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1907"/>
    <dbReference type="HOGENOM" id="CLU_088476_0_0_2"/>
    <dbReference type="OMA" id="AYYVRQY"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="13 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="18">
        <location>
            <begin position="101"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFU58860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="235" mass="26268" checksum="272DA2AECD67A5A7" modified="2012-11-28" version="1">MPEIKLQHILTLVELLSKGARHNFVEVTTTELGKNIGRSQQAASKHLLDLENSGYIERAKKGQKFAVRVTDKGYSEIQSLFFSMRTALESTPAVIDFEGNVVSGMGEGAYYMSLEGYKRQFKEKLGYEPYPGTLNVRLTDQIFMNARRELGKHPSIFIDGFSDGTRTYGWVKCYRASINDGAVENAAVLVLERTHYDDSMLEVIASESIKQATGIKNGDRIKVRVMLGGGHHQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGI5</accession>
    <name>K0IGI5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57948">
        <property type="protein sequence ID" value="AFU57948"/>
        <property type="gene ID" value="Ngar_c10060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10060"/>
    <dbReference type="HOGENOM" id="CLU_982174_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1004-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="283" mass="33693" checksum="BCF787F24E5D8F99" modified="2012-11-28" version="1">MARWNKAQDVSKRLCIDRATKQERKYRLAMTRLKKLTTESRRQRNEFEKKANLLKTAHQRKILAMNSKHHIEKQMWQKKFVVQIKADRKRFEQEFARLKKSYQWQLEHIRHIYDNQTSLLRQELVNTYDRQARVNQDSFESMVAANQGQLEKLQKWLQDELIAQLIEKKQNIENSNLEQVKMAADLKIKKLREALDDREAEIQQLQERLHKAEAKKVAGYAQLLSRKMRGALIPHTEFFANEEISNDRGSENNTTTQDELMNMIREIAQEKSKMDETVKVQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGJ4</accession>
    <name>K0IGJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c35930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35930"/>
    <dbReference type="EnsemblBacteria" id="AFU60506">
        <property type="protein sequence ID" value="AFU60506"/>
        <property type="gene ID" value="Ngar_c35930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35930"/>
    <dbReference type="HOGENOM" id="CLU_146749_2_0_2"/>
    <dbReference type="OMA" id="EHWNTLR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3594-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11681" checksum="7611572E1087C7FA" modified="2012-11-28" version="1">MVAKKMWTLTIRIKKNDELHGKRLYKALLDFMMGAGISGATVVNAVDGFGRRGRSTLRIEGISMNYPLIIEVVDEQSKLEPLLPQIRRMVGDNGIVTLHEVNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW4</accession>
    <name>K0IGW4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">Ngar_c01020</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01020"/>
    <dbReference type="EnsemblBacteria" id="AFU57052">
        <property type="protein sequence ID" value="AFU57052"/>
        <property type="gene ID" value="Ngar_c01020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01020"/>
    <dbReference type="HOGENOM" id="CLU_057426_2_0_2"/>
    <dbReference type="OMA" id="CACCGIP"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFU57052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="27825" checksum="D1E2C08EDC221575" modified="2012-11-28" version="1">MASLRPVQSVLAFLTILPSSSGKQQKQNHDIHYVAKNMYLFPVAGLVIGTIVGAMALGISVAGLHPLLIGLLVAGALVIITGVHHTDALADFADGLMAKGGKEVKRKAMLDPAVGSAGVAALVMYFAGMIIVFQAGFSSSLAIFTSIITAEVIAKYVMVLLANRGLSAWEGFSSPFTAAMKDRRRMAAATAIMLGIVWLASSYAGLIALGVSLAIAGLMKYVSGKSFGGISGDVLGASNEMTRLSSLIVLSLLPPSLPTMMILWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGW8</accession>
    <name>K0IGW8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fic</name>
        <name evidence="2" type="ordered locus">Ngar_c01070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01070"/>
    <dbReference type="EnsemblBacteria" id="AFU57057">
        <property type="protein sequence ID" value="AFU57057"/>
        <property type="gene ID" value="Ngar_c01070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01070"/>
    <dbReference type="HOGENOM" id="CLU_040460_3_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="170"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="366" mass="42320" checksum="DE8B46A53B2BF641" modified="2012-11-28" version="1">MTMVTKRIKGISYYYFQDAVKRPNGQLKIVNTIVGRADLSEKELIKAQAVAFQKHLINMLKFSAIIKKPRAHFENKPTSVSEDELEYIKWLYQNIRKNISESDREEYEKTFLIRYVYGTTAIEGVTLNENETAKVLIEGLTPNNKPLEDAIAVSNYKDVKEFLKGFSGDITEHVIKHIHKLLMKGITGDDRKPIPIGEYRIRGALIRGFGYTPPPAETVPTRMRYLLDEYRRNIKKVHPVETAALFHQKFEEIHPFQDGNGRTGREILNLMLEREGFPPIYITPTERSRYLDALEAGNALNHVPLIDFIIERMNATVMYLFTKTSLYKLWESEEVVVMAAQEEGIPELFNIIKRMMDVLHKSKELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE0</accession>
    <name>K0IHE0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57182">
        <property type="protein sequence ID" value="AFU57182"/>
        <property type="gene ID" value="Ngar_c02340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02340"/>
    <dbReference type="HOGENOM" id="CLU_2968563_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-234-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6566" checksum="894400F383F11DE8" modified="2012-11-28" version="1">MAKFLLTIKPFVTTVKEKKLKYCITCANLATQEACFDVGENVTIVEKYCDTCAMKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHE9</accession>
    <name>K0IHE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57202">
        <property type="protein sequence ID" value="AFU57202"/>
        <property type="gene ID" value="Ngar_c02540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02540"/>
    <dbReference type="HOGENOM" id="CLU_214142_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-254-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5680" checksum="BDBBF0FA20E68FC8" modified="2012-11-28" version="1">MNNSNSKKEDSGSGVSCPYCASKFKDNEELSKHIDRIHHGSGLLEGDSRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ8</accession>
    <name>K0IHZ8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="5 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">aroK</name>
        <name evidence="13" type="ordered locus">Ngar_c16300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="5 10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16300"/>
    <dbReference type="EnsemblBacteria" id="AFU58563">
        <property type="protein sequence ID" value="AFU58563"/>
        <property type="gene ID" value="Ngar_c16300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1602"/>
    <dbReference type="HOGENOM" id="CLU_073768_0_0_2"/>
    <dbReference type="OMA" id="WDVLVWT"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="PTHR20861:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005758">
        <property type="entry name" value="Shikimt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="12">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU58563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="30452" checksum="17A1B6792EE8DF4F" modified="2012-11-28" version="1">MRKARATMHGAISIVNAIATGNGSSLGISLRVTAEAELGRGRGVRFLTGRNEDRLVNNIVRNTMPKEMIENNQVTIRVKSEIPIGYGLKSSSAVSNAVALACSRLARDDDIDDNAVLDAAVRASLDAKVSITGAYDDATACYFGGFTVTDNYSRRLIRREPAPDNLYAIIFLPRNTPRGDVHKLSALSDLFTDAFRLAEAGEYWKAMKLNGVLASAALSSRYAPIMAALERGALAAGISGNGPSVAVVAYEDEIEDIKSALSKFDGKIIISKVNNQKASVEIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ9</accession>
    <name>K0IHZ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monovalent cation/proton antiporter-2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c06240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57567">
        <property type="protein sequence ID" value="AFU57567"/>
        <property type="gene ID" value="Ngar_c06240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06240"/>
    <dbReference type="HOGENOM" id="CLU_2115554_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-622-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="11985" checksum="6DD62885DFC5B99D" modified="2012-11-28" version="1">MDLRGVNVKVLALAGITIAVAVGTKLVDCGLLSIIFLKDRRKAMKVGIGMISRGEVGLIVVATGASAGVLSTNLFSTRVIMVAVSTIITPVWLKLAYRKDPPPEPAVLVEKRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0II19</accession>
    <name>K0II19_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nickel/cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c06740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06740"/>
    <dbReference type="EnsemblBacteria" id="AFU57617">
        <property type="protein sequence ID" value="AFU57617"/>
        <property type="gene ID" value="Ngar_c06740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06740"/>
    <dbReference type="HOGENOM" id="CLU_059308_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-672-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="318" mass="34834" checksum="0509E2980A409D97" modified="2012-11-28" version="1">MDGYVEVKLSVTAILLGGYLIFLSFFLQSANAECISTDPIEVFCGIDLSTGRVSGVYTLHIFGIPTPSLDETAAGVVLPAVILFGLLHGLSPGHGWPVAILYSMRRPRPVFYGLISSGIIAGAHFVSAIAVVVAYIFLTTLVTIPNLYLRLSAAIALGILAYIFWKEEDDHDPIESQHDSLRGTTEHPDHHHEHHQHERKAWHHRISYHSHSHIHQHKKRMPARSLRAIAGFAFVLGFAHEEEFVILALAAGGGDPVGLMIAYASSVAAALVGITLLSLKVYERIQHRIVKYSKYLPKITAVLLLLMAISFATGIGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II31</accession>
    <name>K0II31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58598">
        <property type="protein sequence ID" value="AFU58598"/>
        <property type="gene ID" value="Ngar_c16650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16650"/>
    <dbReference type="HOGENOM" id="CLU_1113905_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1663-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="28389" checksum="551FE49B600C27D9" modified="2012-11-28" version="1">MNERQLKSLFCSALVSGHIKNNDLVPTALDIRIVQEAHSRSFDLLVAAITKEPAEDYAHYNNLLVRTQLLERFARSEKCRIDCVSFYPVEVKSDDDTLDDRLPNQIIDAILAFGLSIVVLDRNHSKKARSLAKFLPATIICYTGVDDHFEVVSKFDRLVSTGTFNLHRTSLARTLGRTDNSKAYSRLVALERILQKLTFNQIYFENLGLTEEELEFLQTLAGVRLPPDGRKRIPRLIKETANTKLTDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0II58</accession>
    <name>K0II58_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rps24e</name>
        <name evidence="6" type="ordered locus">Ngar_c26990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26990"/>
    <dbReference type="EnsemblBacteria" id="AFU59620">
        <property type="protein sequence ID" value="AFU59620"/>
        <property type="gene ID" value="Ngar_c26990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26990"/>
    <dbReference type="HOGENOM" id="CLU_1976424_0_0_2"/>
    <dbReference type="OMA" id="YMSIIET"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14349" checksum="2DAB352B3262CDE5" modified="2012-11-28" version="1">MSAQEIVTLEDRRNSLLNRREVKALFKGAAGKLKKTEAAEKMAGQLNVDKKQVIPINLVCHTGMTDVHAVFYVYDDEKEAAKQLPRYRLLRTLPKEERKKIIDEEKATKLKAKQEAAASKGAAAGGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0II92</accession>
    <name>K0II92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57702">
        <property type="protein sequence ID" value="AFU57702"/>
        <property type="gene ID" value="Ngar_c07590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07590"/>
    <dbReference type="HOGENOM" id="CLU_1607211_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-757-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="167" mass="18253" checksum="040A0D29C7612D1E" modified="2012-11-28" version="1">MIIGPRRLVLIGAIAAVALTIIFYPLLVRTPFDPQKVSFELTKVELISGSEGEQQLVVQPSLRITNTNDFTLTTSKIDYELFADGVLVGSDTISYEDVPINGRPALFPNQPVTLRDTDGLTLRYSDANADLFNRILGNSTEIGWSIQGSANIESGTTLETTQFSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID2</accession>
    <name>K0IID2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57787">
        <property type="protein sequence ID" value="AFU57787"/>
        <property type="gene ID" value="Ngar_c08450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08450"/>
    <dbReference type="HOGENOM" id="CLU_1623510_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-843-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036369">
        <property type="entry name" value="HIPIP_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="17962" checksum="15E1D7DA76C38D83" modified="2012-11-28" version="1">MGAKESADAKAKGSQNELDMSQPDTTFLQVLSQKKKVAKDEANYVLNGTGERKSCVKCKFNLGDEGKCHIVRGKINNEKGVSKFFSPKGDGMLPGDIVWIYVKQTGKKLKYKEGHVIHEGAPGYQCKDCKYYLYSGDCLLITGKFKPKMSCGFIVKIGHGTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0III4</accession>
    <name>K0III4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57882">
        <property type="protein sequence ID" value="AFU57882"/>
        <property type="gene ID" value="Ngar_c09400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09400"/>
    <dbReference type="HOGENOM" id="CLU_453903_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-938-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="636" mass="70810" checksum="C06C75EA27B2D170" modified="2012-11-28" version="1">MQQETTFSNRILEILGSKSSLLTIVASASLAVLCLFYIFSIGTQFQVRIYTLIDRVTHFTNFEFYIVSEFVDHVIIGSFSVLWLVFSLKSKIHRMMIGTFAALFVAAAITNYDPVLDGIALAALPAIVLLIIYNQYSRKILDNIKLKLAINYIAITGIIIGLISFTSAILSISSLSNDETLHRNYAHEIFLLFSSVSPILILLLLTSYPAKLLINFVSSVTGRLNVPAAPGYDNSDTINSKMKVIYLSIFVFISMMMVIIPHLPAINNDNQHIGVDTPVYNLWLNELSGAKDVQEYFGKAFVEINGGDRPLSLILMLAFQELIPAGNENNSDLRLEYLPLLLGPLLVLTTYLLTRELTMNDKTSLLAAFLTSVSYHVLIGVYAGFYSNWISLICGYLAFFFLLRFLRQSGAVNLSLYGILMILTLFSHVYTWSILAIVMGVFLAICITRWNIHIETVHNQNQGSKSSIIKKNAMAILIVLLCTVAIDIGRVALTGSSGGIERDLELGSKLAGIEQFALRWNNLTYGTTVYVGGLFANFLILGLGIYWLFTSKLKERENIALVIFLSIGILPFLFGDWVIQTRVFYNIPFQIPASIALLTIIKQTDSGLLRSIPIFIWLVAISLILVSNFHLVLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIM4</accession>
    <name>K0IIM4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57942">
        <property type="protein sequence ID" value="AFU57942"/>
        <property type="gene ID" value="Ngar_c10000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10000"/>
    <dbReference type="HOGENOM" id="CLU_3210876_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-998-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="44" mass="5292" checksum="78A4AEBFC5094EE8" modified="2012-11-28" version="1">MPVEKVYHKAKGEIIKYTCDFCNAEYDNQKDLFEHANFVHKMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP9</accession>
    <name>K0IIP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59805">
        <property type="protein sequence ID" value="AFU59805"/>
        <property type="gene ID" value="Ngar_c28860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28860"/>
    <dbReference type="HOGENOM" id="CLU_2581539_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2886-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="8983" checksum="42240E9EBBB63FA9" modified="2012-11-28" version="1">MRLFGWKPKGKMYSLKCNQCGSGFLSSYNLEAPICGKCLQKAKSLDSTIEHDKHCSKCGSSGVIYGKEYCYSCYFNFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIQ1</accession>
    <name>K0IIQ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58948">
        <property type="protein sequence ID" value="AFU58948"/>
        <property type="gene ID" value="Ngar_c20160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20160"/>
    <dbReference type="HOGENOM" id="CLU_1691593_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2014-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17316" checksum="B2E3686274894D58" modified="2012-11-28" version="1">MTLSERGGEIAAIIGIILVAFFFYTHQAWCTGFFTSASASTEAFLLYGSILTGMAEPVARLATGRRNISRLPELATSIFWIVSSVWLFYVFPFNFAHFADVVPEFLRFLVSWITNDIARILFILGILGGVAFISVNVMLYLKVRRLLHQQAVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ25</accession>
    <name>K0IJ25_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59108">
        <property type="protein sequence ID" value="AFU59108"/>
        <property type="gene ID" value="Ngar_c21780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21780"/>
    <dbReference type="HOGENOM" id="CLU_1003321_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2176-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="31915" checksum="A6904334E26926A6" modified="2012-11-28" version="1">MKKTSNNNLLHASDRQHLMLLYDNESERHAAEIACINEALKLGEYCMYASVDLHDRNFASKLASKIHDYDRHIKEGNLWLVDFMPFYESALNADLMLFNELKKQIEAKLKGRIASRKSSKVLIVADAACNLTKHMQFDECIALESWWQETYIEWARRNLDITIICAHPSLVLEQDYHSKNHISQSHSLTIDLQQFSKPIIIGNRTRGVYKPKASSIRILVAEPEPDMQTVYKEYLGSLPIDAVIARNGRECLERILTPGSKERFDMIIIDSHLKDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ38</accession>
    <name>K0IJ38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31190"/>
    <dbReference type="EnsemblBacteria" id="AFU60035">
        <property type="protein sequence ID" value="AFU60035"/>
        <property type="gene ID" value="Ngar_c31190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31190"/>
    <dbReference type="HOGENOM" id="CLU_125301_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3119-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15843" checksum="483EED78120AFC31" modified="2012-11-28" version="1">MKILHHNKLVDVTKSIAEEHGIIQKFFSSAAYLFVYDLDAMPKDVARYFYPISLERARTLVSVIMADTQSPSSFSSAKGSLNRGDIDEISAVLSRLLVLVAKQYSRQRASYGDESIVYEIYTKVFNLFLKQLELPAGNKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ40</accession>
    <name>K0IJ40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybutyryl-CoA dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.55" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21980"/>
    <dbReference type="EnsemblBacteria" id="AFU59128">
        <property type="protein sequence ID" value="AFU59128"/>
        <property type="gene ID" value="Ngar_c21980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21980"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2177"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_2"/>
    <dbReference type="OMA" id="GLRFERH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2196-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003859">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="282" mass="30567" checksum="3AF1D1B5BA0F4261" modified="2012-11-28" version="1">MKYIQLEPQGDIAIVRINRPEALNAMNVDVIAELSKTIDILVADESVKVVIITGAGERSFCAGADISYMVNIEPMQAERYATSAQAVINKIERLEKPVIAAVNGFALGGGCELAMACDIRIASSNAKIGQPEVTIGIPPGWGGTQRLMRLVGPAKAKEMIFTGKMITADEAHQIGLVNKVVSLGPDDKVPPEVKGDPAKEKERAAEVAKILNKKLMDECLALAKEITKNSFVAVKVSKMLINRGMDSDLETGLRLEIYGWALCFAHEDRQKMMSAFLNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ57</accession>
    <name>K0IJ57_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59138">
        <property type="protein sequence ID" value="AFU59138"/>
        <property type="gene ID" value="Ngar_c22080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22080"/>
    <dbReference type="HOGENOM" id="CLU_096711_0_0_2"/>
    <dbReference type="OMA" id="CLQYPHH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2206-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="254" mass="27930" checksum="94C9564871C3050A" modified="2012-11-28" version="1">MTLNIAVHSFKGGTGKSTITANLAVLLALEGRRVGVLDLDLAGPGLHVLFEMTPDEIKHTLNDYLLGLCSSEDIAIDLTEKMNLKQGSLVFVPASFKAEDIIKVLSKGYEIGMFRDALAVISRLHRLDYMIIDTHPGIEKSTLVSMGICDMNIIISRMDSQDIFGTGVMLEVTRVLEKPQILIANMIPPGVDKEKVRARLETLFNAKVITAIPFYTEILRALSSEVFVLKNPNHDFSTALRPAIEALEVKANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJR1</accession>
    <name>K0IJR1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60315">
        <property type="protein sequence ID" value="AFU60315"/>
        <property type="gene ID" value="Ngar_c34000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34000"/>
    <dbReference type="HOGENOM" id="CLU_1691595_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3401-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17918" checksum="E7ED5510E0A5737E" modified="2012-11-28" version="1">MKRNLREEQTDWGILVSKVFPSNALNDKMYIDTSGILVVKTDYASAAYLGLRHAVIHQFQVQSRLNTQQEREGAHDQILGVLKDWMQGNKLKDVFAKIDEARKATIETEDLLQKLQTYNERTVKSSREFQIKIRGWLQESTQILGELQEKLPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK28</accession>
    <name>K0IK28_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 12">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">uppP</name>
        <name evidence="13" type="ordered locus">Ngar_c35720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 12"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35720"/>
    <dbReference type="EnsemblBacteria" id="AFU60485">
        <property type="protein sequence ID" value="AFU60485"/>
        <property type="gene ID" value="Ngar_c35720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3580"/>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_2"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU60485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="29030" checksum="E6D6556B50B068D1" modified="2012-11-28" version="1">MAAVDILQAIILGAIQGLTEWLPISSSGHLALVQLAMGLKVPVFYDAVLHLGTLTGVFAIYRKDIANVVKSIFGQNRAEAKEGAHRPQGGRMLWFIVLGTIPTATIGLAFSSFFEYSFYDPLSIGVGFIVTGVFVLITLFLKAGSKKLDAADAVLIGVGQGLSIFSSISRSGATVAAGMFRGVEREQLVRYSFLLSVPAILGAAAVDMISADEQERAELYSIGIESYIVGAAISAAVGYASIRVLIRLVIRGKFYLFAFYCFAIGIATFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK42</accession>
    <name>K0IK42_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17240"/>
    <dbReference type="EnsemblBacteria" id="AFU58657">
        <property type="protein sequence ID" value="AFU58657"/>
        <property type="gene ID" value="Ngar_c17240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17240"/>
    <dbReference type="HOGENOM" id="CLU_107017_0_0_2"/>
    <dbReference type="OMA" id="PCEYCET"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1722-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="188" mass="20833" checksum="E963033260CA12D2" modified="2012-11-28" version="1">MAETLFQKDVRIKRVTTLGYSAAQALNDPVRIKILEILSHKQMSADEIAKALGSSGYKKATTTIRHHLDTLKSAGLIEATKMVEVRGAVMKYYAPTLRAFSYDVPDLEKHAKLVDDTGTRLLKVLKSVLEDKKFVAAFAGKDDVCSQCKGDHYKEYAALEILNAALAKAMGRKEYVEMIVAGKEQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE3</accession>
    <name>K0IKE3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative repair helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19350"/>
    <dbReference type="EnsemblBacteria" id="AFU58867">
        <property type="protein sequence ID" value="AFU58867"/>
        <property type="gene ID" value="Ngar_c19350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19350"/>
    <dbReference type="HOGENOM" id="CLU_1025332_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1933-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="89"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="271" mass="31174" checksum="3BCA88E640972FAA" modified="2012-11-28" version="1">MKAWLHEEKRSGLEPRQHIIFTSAFELLACSSSQQKNHEPARRSPADDDYNHYSPPNMNFETNHHHRPPAITDLSFSFALKPDQVKAVETWISNQCRGSVIYGSGIGKTEIAFECARRLAVLDRANRRRFNVLLLVPRKVLVQQNYDRLVRYKVSPERLGRYFGEEKQINEITIATYHSALANPGIVRRADRVIFDEVHLARGAFGRIIFDSIISENHGKALLGLTATIDKNDPRNVAIIGLLPPVRKYLIKMRFLTKDWQGQSYFPSMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKI3</accession>
    <name>K0IKI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59783">
        <property type="protein sequence ID" value="AFU59783"/>
        <property type="gene ID" value="Ngar_c28640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28640"/>
    <dbReference type="HOGENOM" id="CLU_3003268_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2864-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6124" checksum="96984539AD603A92" modified="2012-11-28" version="1">MAQKSVICKSCKRKFLAPAVDTGRQEISSDIDESAAFALICPFCMAHALYTAKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKL4</accession>
    <name>K0IKL4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major intrinsic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c20910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20910"/>
    <dbReference type="EnsemblBacteria" id="AFU59022">
        <property type="protein sequence ID" value="AFU59022"/>
        <property type="gene ID" value="Ngar_c20910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20910"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2071"/>
    <dbReference type="HOGENOM" id="CLU_020019_3_4_2"/>
    <dbReference type="OMA" id="IFKALMY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2089-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="239" mass="24990" checksum="8B327DB1585B5ECB" modified="2012-11-28" version="1">MVNPRAWLAESIATFALVFFGPLSVTMAAVLFGTGLSLEGIIMISLGHGAAIGIMIYTFGHISGAHINPAVTIAMMVTRNINIKDGAAYIGFQIIGAIAAAVAHMAILPEAGKQVNFGTQGGPSELLNFSAASGVGVEIILTFFLVTTIFMAAVHRKATAGMAGIAIGGMIFLLHLVGVPLTGASMNPARTLGPAIVSGYWDFHWIYWVGPIVGAIIAGLIMQYVYVKKAEKEEKKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKY1</accession>
    <name>K0IKY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blue (Type 1) copper domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c22770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22770"/>
    <dbReference type="EnsemblBacteria" id="AFU59207">
        <property type="protein sequence ID" value="AFU59207"/>
        <property type="gene ID" value="Ngar_c22770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22770"/>
    <dbReference type="HOGENOM" id="CLU_759957_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2275-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="283"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="364" mass="38840" checksum="456F027DE3EE3C11" modified="2012-11-28" version="1">MNNRKIVLLAGLSAAIIAGTVLVQPSIYAPASGSYNATTAANNDNNSTSTTTSDDSELTTFEEEAIKAGEEFEDNNTTATTSANATASNETSISNETTNMDQETSAAAATGDNKTIVLQGTVSSPGEEAGPFQIIDLLPPTLDGNIYTGWVSFTATKPILVAPLHTYNVANETLDPRFGELFVFPGIPNGTMIAPAITMPDYATQNEINSDIPMPKTYSATVPFTASGLSVGRLDGKQFLVSYTLYATVHLAETVDNVDSAITNQTQVKGIEAIIVSRAAFLNDTAYSPNPIEIKRGDTVTWVNKDFDQHTVTSGSFGEKDAGDEFDSGYMGPQTTFSHTFKQKGEFEYFCELHPNMGGVVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL14</accession>
    <name>K0IL14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23260"/>
    <dbReference type="EnsemblBacteria" id="AFU59252">
        <property type="protein sequence ID" value="AFU59252"/>
        <property type="gene ID" value="Ngar_c23260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23260"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_10_2"/>
    <dbReference type="OMA" id="HGQFWDM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2324-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="1">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="310" mass="34758" checksum="EA42C1EBF2074752" modified="2012-11-28" version="1">MQLERSAAKANAPDFLKQIGLALGALQAERQKKSIAGGKVNGGLVEIQKLEKLAVVSDLHGDSKSLFRILSELNYEQFLSDPMNKLVFLGDYVDRGSDSMGVMYAVCHLKSTYPDSVVLMRGNHEAPAEFPFSSHNLPYEIEERFGSCSKEVYQRLLSMFKLLTLATVVRQKLLLVHGGLPTENATMESLATAQENHIRSRVLEELLWNDPRQIDIEPGWEMSRRGLGRHFGSGVSRMWLQRSGAKVIVRGHEPCQGFRLDHDGAVMTLFSCKEAYPKFKAAYLALTAGQLDDINDARDLSRYVRFPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL18</accession>
    <name>K0IL18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59262">
        <property type="protein sequence ID" value="AFU59262"/>
        <property type="gene ID" value="Ngar_c23360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23360"/>
    <dbReference type="HOGENOM" id="CLU_3021093_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2334-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6407" checksum="85AE645F18A59E01" modified="2012-11-28" version="1">MKTLNIDDQTYRRLASIMNDMMHTKKHDINYDDVINELIDVYQDSLRFSGENAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL84</accession>
    <name>K0IL84_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c33080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60223">
        <property type="protein sequence ID" value="AFU60223"/>
        <property type="gene ID" value="Ngar_c33080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33080"/>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_2"/>
    <dbReference type="OMA" id="CIYCQNM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3308-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="432" mass="50071" checksum="03028B2AF6735628" modified="2012-11-28" version="1">MTKSTARQFESLKIWESFKDRLPWYFAVSTNHMPAKYLIAKCIPSNLDRLSSANEKELWNEHILLTEVFLDKWKKVRTREMPDLSKAVAGGHHPSLLDLSVELANRMLTHCNFCRWNCKVDRSKGTRHGTCQLESTSRVGSYFHHRGEELIFRGIGGSGTIFFTSCNMRCSFCQNGDISTDKDNGIPITPSALALMAWQLRMEGCHNVNWVGGEPTIHLHTIVEAINLLDSFTKPDTRQLKYIQSVKSDDGNYYFDSWQTNSEHAFYQGQLFNCPQLWNSNFFMSQEAMHILRNIMDVWLPDFKFGPGKCAFDISRTPWYWETVTGNLKLVHEWGEDMVIRHLIMPNHIECCTKPVLEWIAKNMPEVPVNIMDQYHPDNLCDPESSKYRERYNDISRACAPEEISLSYQYAKELGLNFEPLLYEKSAAFYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL89</accession>
    <name>K0IL89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59367">
        <property type="protein sequence ID" value="AFU59367"/>
        <property type="gene ID" value="Ngar_c24430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24430"/>
    <dbReference type="HOGENOM" id="CLU_1656927_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2441-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="159" mass="18015" checksum="1102726C573ADFBC" modified="2012-11-28" version="1">MPLEVVFAYLEPKETVYRIPCGQGPPGYFYRSFYFSGAGSTIIDEYHPNAQSLFDIASPTQAAEYVMYFDIVLSGEQGNKQFVITKDQYDRWAEQCIKEEDNNKTSAVKELTVTSLGDSYDVQLNFVSGSFEYRHYVVNRNGTIERLAEEALGHCGFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD1</accession>
    <name>K0ILD1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57009">
        <property type="protein sequence ID" value="AFU57009"/>
        <property type="gene ID" value="Ngar_c00590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00590"/>
    <dbReference type="HOGENOM" id="CLU_170073_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-59-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="9231" checksum="C4B25BB1AF99EFCF" modified="2012-11-28" version="1">MLATHSITITEEAYKALKRKKKETESFTDVILRLTGEGNIRQFRELLESKDFPDRELADNIEKASKEFGENFKLRNVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG2</accession>
    <name>K0ILG2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01090"/>
    <dbReference type="EnsemblBacteria" id="AFU57059">
        <property type="protein sequence ID" value="AFU57059"/>
        <property type="gene ID" value="Ngar_c01090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01090"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.113"/>
    <dbReference type="HOGENOM" id="CLU_038336_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-109-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="DUF790"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="PTHR39640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="606" mass="69091" checksum="F713788A632D8505" modified="2012-11-28" version="1">MVKEFQESCRAHERKFELYNRISAIESSHNDYKLIRGFCALLERRCVFNNAYCSARHITNNTTNNEPAPSGDGAGTTTIAIDPIDVRRMLFEESSKKGFALTDLERNSIINSISEKLHISPDDVIRVMWSDLDDNLIFEHFADIDAKTLVGWYNLSLMQTLLFNATKMEFQISGGTNWKRILRNVKRLGLMYYLENRSQRHNEGNENDIASTSSLVCSLEGPLSLFKLTDRYGTSLAKLLPSIVLAKGDVDWQIDAWILRKTMMMQGKKLYQFKISNSETLPFLSDPFFATKYDDNQNGQKKTGSAAFTSSECYSFDSLVEEKFARKFNEVVGETSGWKLVREPDPLIVANGKAFIPDFMFEKYGNRVYLEIVGFWTPDYLERKLQKVRQIMKANSDDSSNNNHHYNTRKNTTTVVDLFIAINEELAGSRISSSSSSFATFSSTVPMDRLIFYKNDSVPIRPILDYLKAVDKEMIDRKTRDPSLRIEVDRSKDIISLKDLAQKYDLPIEVVSKIVSRDYSDQYISVGGGGQQQQHHYLISKAKAKKLELLLKEVKAFTDACQILSENAIPEACHAELVDKLGYDVIWRNMDVSSAVIEKKKNDITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK5</accession>
    <name>K0ILK5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemD</name>
        <name evidence="2" type="ordered locus">Ngar_c26100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26100"/>
    <dbReference type="EnsemblBacteria" id="AFU59532">
        <property type="protein sequence ID" value="AFU59532"/>
        <property type="gene ID" value="Ngar_c26100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26100"/>
    <dbReference type="HOGENOM" id="CLU_011276_9_5_2"/>
    <dbReference type="OMA" id="FTSSMMV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="28881" checksum="1B669BEC51BCB489" modified="2012-11-28" version="1">MPGLLKNKIIAITRSERDAKEFSELVSKQGGRPIALPTIEIVPKEAEVGQEFLEKLRKEKHDYCAFMSPQAVSVLFDLAGNEAVLSALKSTTVIAVGPKTKEVLQERGVKVGLVPEKFSSAGLVELLSSSIKEPAGKKIIIPRSGAANEYASEALGRLGIKVDEVLLYNVRTSATITPVWHEFASLLRQKKVDAIIFTSASNVSSFFEIMGIVSAASGSLLQLDELTKVVSIGPFTSRELEKRQIKCFQAEEHTVMGALKLATQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL4</accession>
    <name>K0ILL4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpl13e</name>
        <name evidence="4" type="ordered locus">Ngar_c26250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26250"/>
    <dbReference type="EnsemblBacteria" id="AFU59547">
        <property type="protein sequence ID" value="AFU59547"/>
        <property type="gene ID" value="Ngar_c26250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26250"/>
    <dbReference type="HOGENOM" id="CLU_2662486_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_L13e"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8554" checksum="27BB78CC78610838" modified="2012-11-28" version="1">MQAAKPTVRNGYIVRAGRGYSLDELREAGLDLRVARKSGVPVDMWRQTKYPENIEQLKSIAKTIIIVPSKKRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ1</accession>
    <name>K0ILQ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">Ngar_c02710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02710"/>
    <dbReference type="EnsemblBacteria" id="AFU57219">
        <property type="protein sequence ID" value="AFU57219"/>
        <property type="gene ID" value="Ngar_c02710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.265"/>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_2"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="482" mass="51892" checksum="17A5F5255FA8F744" modified="2012-11-28" version="1">MVALYTLDAGQVAAGVKSREFSAEEYIYQLLERIEKVEPKVNAFVTVNNKEAIDRARAIDKKVRDGEQAGALAGVAVSVKDNICTKGIKTTCASRMLEAYVPPYDATVVKRLQDAGAIVIGKANLDEFAMGSTTEFSRHGTTRNPWDISRVPGGSSGGSAASVAALECTVSLGSDTGGSVRCPASFCSVVGLKPTYGLISRYGLVSYANSLEQIGPLGRTVSDAVSVLNVIAGADENDHTTAGGKPTYSLQERKKGLRVGLVQEFIEGADPAVAKVIHKAADTLVGQEGCTCEQASLASVQYALASYYTIATAEASSNLARYDNVRYGFDLSPEGYEWNSYFAKARSNFGEEVKRRIIVGSYVLSSGYYGKYYLKAQQVRSLLKRELKALFKKYDVLIGPTMPILPFKIGEKIDDPLKMYLVDIDTVVANLTGMPAMSVPAGFADGLPVGLQIMADEFQEQTMLDAAYLFEQAAKVQRSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILT1</accession>
    <name>K0ILT1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03320</name>
        <name evidence="3" type="ordered locus">Ngar_c03610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Enrichment culture Ga9.2</strain>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57280">
        <property type="protein sequence ID" value="AFU57280"/>
        <property type="gene ID" value="Ngar_c03320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57309">
        <property type="protein sequence ID" value="AFU57309"/>
        <property type="gene ID" value="Ngar_c03610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03320"/>
    <dbReference type="KEGG" id="nga:Ngar_c03610"/>
    <dbReference type="HOGENOM" id="CLU_1052175_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-332-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="264" mass="28587" checksum="7894A8CD659B01FA" modified="2012-11-28" version="1">MPILIITPDSGKAGDKVALQSSGWTPNAQLVYEWPAINFRIDDLRADESGRFDRFISIDPLLKPGTYKVRMYERLKPTNIAEATFTSTNLTPGTKVVTRGNPVYFFNGDQVGPSPAQARKTITWLGNLKSAILVVNFANKPGWVLEQATLNGKNYAPTSHNNISAEVKDALINGDNTLTIHYATPFLTPHLGDRNTLTAYIIPDVETIAGLSGIVSDMPSLDLLVKDIDKRLANATIPTIIILVAIAIISVAIAAIFGKVGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW3</accession>
    <name>K0ILW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59732">
        <property type="protein sequence ID" value="AFU59732"/>
        <property type="gene ID" value="Ngar_c28120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28120"/>
    <dbReference type="HOGENOM" id="CLU_1478962_0_0_2"/>
    <dbReference type="OMA" id="GHESIPA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2812-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="182" mass="20294" checksum="822E7AC7DA4D219F" modified="2012-11-28" version="1">MFGDPYAKLCFAAHLVSQFEKVTYIDLDTTFTAYFNAGLVQAKNSVDIYLPSEGRLVPMVKDVLESMGTSSLVIFDSVNSFYNLFRAQERTGGLNHLLAVLLMLLVRHGVNQNIPVLATSMLRYRKDGGWVQSPASRRLLQRKSAAKLSIERIERDLAVTVIGHESIPAGTRLVYKDSLITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW4</accession>
    <name>K0ILW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57399">
        <property type="protein sequence ID" value="AFU57399"/>
        <property type="gene ID" value="Ngar_c04530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04530"/>
    <dbReference type="HOGENOM" id="CLU_1860787_0_0_2"/>
    <dbReference type="OMA" id="HIRMETK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-452-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="14961" checksum="CBD5751E6A8F9617" modified="2012-11-28" version="1">MSAAEEDPDIEMIKARKLKELREKAAALEKSKSTVGQPKKKKSAREVVSGYLYDRGDEVLDLAYAQYPAQTEAIVTRIAELMLSGEITSKISGGELLALFRSVGLNVRVNTTIRVEDKGKLISFSDKLKQQNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM10</accession>
    <name>K0IM10_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59867">
        <property type="protein sequence ID" value="AFU59867"/>
        <property type="gene ID" value="Ngar_c29490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29490"/>
    <dbReference type="HOGENOM" id="CLU_1182908_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2949-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="234" mass="26234" checksum="4BDB35431B1638DB" modified="2012-11-28" version="1">MIYETIKNATGWQAPTTPYGQVFSSPDELTVQTAGLLSTGALWKEGSSAPYDLKYGGTSQAYRKTCTWEVRTGSGESCQGGKIWFKKAFVARTPGGSSSTNKIVNRHWCYFNNQQTQTNRFECATTYVTFKVPFGFNSTKGKNYFIESIDWKLYSPTYSNSQNNNDDPSWTKHKFVGGGFSTYKTFVWTPNNVPMYKHGGGHEPILITVKANYHCLPNPPISVTIILDMTKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM11</accession>
    <name>K0IM11_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59872">
        <property type="protein sequence ID" value="AFU59872"/>
        <property type="gene ID" value="Ngar_c29540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29540"/>
    <dbReference type="HOGENOM" id="CLU_1987694_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2954-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="14366" checksum="A4259DC4F1A6B44F" modified="2012-11-28" version="1">MSSYFEGRQIGYTDEREAWAMLLDGISASPDLLLSQKAEQLCMIEGINYKGLEPIQRLFLTHYRCPICKLLPLYHLNLAHPKRVRCSKCGNLIQFTSAGKYGRLRKKIAFMLWISLEGKRRNGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM30</accession>
    <name>K0IM30_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rps6e</name>
        <name evidence="6" type="ordered locus">Ngar_c05810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05810"/>
    <dbReference type="EnsemblBacteria" id="AFU57524">
        <property type="protein sequence ID" value="AFU57524"/>
        <property type="gene ID" value="Ngar_c05810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05810"/>
    <dbReference type="HOGENOM" id="CLU_109671_1_0_2"/>
    <dbReference type="OMA" id="DGFPMRP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_S6e_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="14726" checksum="E650B10769817978" modified="2012-11-28" version="1">MAQFKLVISDTKGRTISQELKDRAAQPLVGSRIGSIIDASIIGVAGGKLKITGGSDKSGTPMRGDVHGGVKKYVLLSTGVGNRSEARMRKLVRGNMVTEEIYQLNCMLIEGTLPQKQQATEAAAAPETITAAESAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM51</accession>
    <name>K0IM51_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c30910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2015-06" db="PDB data bank">
            <title>Hydrolytic Potential of the Ammonia-Oxidizing Thaumarchaeon Nitrososphaera Gargenis - Crystal Structure and Activity Profiles of Carboxylesterases Linked to Their Metabolic Function.</title>
            <authorList>
                <person name="Chow J."/>
                <person name="Kaljunen H."/>
                <person name="Nittinger E."/>
                <person name="Spieck E."/>
                <person name="Rarey M."/>
                <person name="Mueller-Dieckmann J."/>
                <person name="Streit W.R."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="5A62">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A=1-277"/>
    </dbReference>
    <dbReference type="PDBsum" id="5A62"/>
    <dbReference type="SMR" id="K0IM51"/>
    <dbReference type="STRING" id="1237085.Ngar_c30910"/>
    <dbReference type="ESTHER" id="nitgg-k0im51">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60007">
        <property type="protein sequence ID" value="AFU60007"/>
        <property type="gene ID" value="Ngar_c30910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30910"/>
    <dbReference type="HOGENOM" id="CLU_020336_53_0_2"/>
    <dbReference type="OMA" id="AGSYKSW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3091-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5A62"/>
        </source>
    </evidence>
    <sequence length="277" mass="31091" checksum="9D4C5CBD0B9E631E" modified="2012-11-28" version="1">MPFLSSPSNSVSTYYEDHGDARSYPLVLIHPIGGNILIWDYEIQLLLKSGFRVIAYELRGHHRTNMGKTGAYTMQDLIDDLRRLLEHLNIGKCTIIGHSIGGIISSMYAAQHPGKVDAIIMINGSPKKFQEKDLEKHFRTREVAITQGMKALAEHKLVSLDEARDLFADKRHADFFREVFTKTSVEGFVAATVALYTIPGNVVQGLRASGCKVFAIVGSDDDVFMRLIKETKEEIPEMELRVLQGSDHWVVIEKPKEMYDILMGFLAIVTKDVKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM85</accession>
    <name>K0IM85_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31760"/>
    <dbReference type="EnsemblBacteria" id="AFU60092">
        <property type="protein sequence ID" value="AFU60092"/>
        <property type="gene ID" value="Ngar_c31760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31760"/>
    <dbReference type="HOGENOM" id="CLU_1406023_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3176-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="193" mass="20933" checksum="AF2E1530BCEBC6F5" modified="2012-11-28" version="1">MIIVFAAIAAAVSGAALAQNQMPSTGTLTDNNTASSMTLDEAKEQYLAAWNQTEFDAAFSTFVEEFSAAGYGVYQEHGNVFRPGETMVLYVEPVGFDHEQVIDEEGNTLYLMNMTADYVIASGNGTELQVIEDIPVGSIVSHRSNMELFLELTLTQASPFPVGDYLITYVVTDEVSGESFMLEKQVTVAESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM90</accession>
    <name>K0IM90_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57659">
        <property type="protein sequence ID" value="AFU57659"/>
        <property type="gene ID" value="Ngar_c07160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07160"/>
    <dbReference type="HOGENOM" id="CLU_3338592_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-714-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4098" checksum="0BECA07BD7C01618" modified="2012-11-28" version="1">MAVADYGSYVFDHWSDGSTNRFHDAAAGDSLMAVYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMB2</accession>
    <name>K0IMB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07770"/>
    <dbReference type="EnsemblBacteria" id="AFU57719">
        <property type="protein sequence ID" value="AFU57719"/>
        <property type="gene ID" value="Ngar_c07770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07770"/>
    <dbReference type="HOGENOM" id="CLU_1243058_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-775-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="26925" checksum="EE1812FF920108C0" modified="2012-11-28" version="1">MAKCEASAEVMGTDHKRKENQQPIVMMLTDQQDIIDRLTRIFVNADSEICACIESETPIATTDIESLVKAKLAARKRGVKLRYITEIKEGNLYYCRKQIGMITELRHLDFVKGNFVVSDKEFLSVPLIPEEGPVTEGIYTDVDAIVLQQQLIFETLWKKARPAEERIRELERRYNSQEKFVEEENNKKQQKIIDRIYLCMKCGASFIYRGEALQHVSETGHDETREFPFGNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK6</accession>
    <name>K0IMK6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">flpA</name>
        <name evidence="5" type="ordered locus">Ngar_c34570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34570"/>
    <dbReference type="EnsemblBacteria" id="AFU60372">
        <property type="protein sequence ID" value="AFU60372"/>
        <property type="gene ID" value="Ngar_c34570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3456"/>
    <dbReference type="HOGENOM" id="CLU_059055_2_0_2"/>
    <dbReference type="OMA" id="INMATHR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24562" checksum="2377FF1264893887" modified="2012-11-28" version="1">MESDAIRWISVNGEKNAATLNLVKGDSVYGEKLVKHEGEEYRLWDPFRSKLAAALKKGMKNMPIKNGSKVLYLGASTGTTVSHVSDIVGPSGIVFAVEPATRVARELIENVASKRKNVLPILEDARKPQSYFAVFGKVDVVYCDIAQPDQTDIAIANCAAYLKQGGVMLLVVKTRSIDVTMDPRAVVTQEASKLEKNGFAIEQIINLEPFDRDHGMIYCIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP3</accession>
    <name>K0IMP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60457">
        <property type="protein sequence ID" value="AFU60457"/>
        <property type="gene ID" value="Ngar_c35440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35440"/>
    <dbReference type="HOGENOM" id="CLU_2784244_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3545-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7644" checksum="AD8FF40B43180C0A" modified="2012-11-28" version="1">MNDSIEYTQVTPPIMAKMPAARAIVDGSDDLFSRIFSQCCENDCCNMVMIDTGYNTTILRIKEDELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP4</accession>
    <name>K0IMP4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58074">
        <property type="protein sequence ID" value="AFU58074"/>
        <property type="gene ID" value="Ngar_c11320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11320"/>
    <dbReference type="HOGENOM" id="CLU_1259132_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1130-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="219" mass="24837" checksum="5EA5D094063650B4" modified="2012-11-28" version="1">MQELLKGDAFLFAQRLDSKPVYTIEDAISVAGSAKTAYRRLNDLKVLGLAKYKRGSFILKTNVVTQPANIIEKLLPSLIALSRARRFGRNYNDSDIRFAMNNISDKFVTLDYKAYELTKFQTPLDLYIYVKDVDKVAGFLKEKGFKEGKNGHVILLPKIGDFSNEIERVYLDCIANGERSTMDAIAIELLYEDRLSTRGLFPVQLVKKVQEDLPLSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ3</accession>
    <name>K0IMQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60482">
        <property type="protein sequence ID" value="AFU60482"/>
        <property type="gene ID" value="Ngar_c35690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35690"/>
    <dbReference type="HOGENOM" id="CLU_600815_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3570-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="455" mass="50495" checksum="9C73F68993B66445" modified="2012-11-28" version="1">MAHTTPEYERRTTLLPTIMMIIITAVLVVDISLSFVPDLQSIPGSWTNATFVVLVSIFAIGQFIVIRYIEQLINKGAVRARGIKIFHKVTKIVQYVLAAVLVFTALQLLLTSEYSTVILQMGSSIAYGLSVAVMAFLSFLFLSWYRSNKNLVVFSYGVSSAIVCISLSLLIAQNYALLSGLPAERDAQSEPNLPFPNDIMYLTALSSAVSFFLLWFSTALLLHHYSSRIGRAKFWLIMGAPIFSFVIQFSVLPQITAAYANPYTDMLYLVLLGNVLPAVTTGILFGVPFWIISRTIRNEVLRRCMSIAAWGSALLQLSSLAGIYLALYPPFGLYGSLSTGLACYLILVGIYSSALMASIDRKLRLFIKKNTIERTMKLINVIGEAEMKKEIEGQVLQISQKYADKMTDETGMPSSITQQEIEKYVETAIEEVRNSKSLALKNDARRNSKADSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT4</accession>
    <name>K0IMT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58179">
        <property type="protein sequence ID" value="AFU58179"/>
        <property type="gene ID" value="Ngar_c12390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12390"/>
    <dbReference type="HOGENOM" id="CLU_822875_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1237-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="337" mass="38795" checksum="688909BD86E235B4" modified="2012-11-28" version="1">MEQVRFPMIPRFPENVPYYNKDEFIRHLHKLQPTMTICIAAICEDWDGAFPRIVFCADRLVTALIQYESGQTKITRLTPYCFALSSTNNSQVSDMILENVREKLENETKHLKIKEITEMVKAELINVKNTSIEEDVLAKYNLTAKKVNIDPAEFADRAMNEVSRYRYPLVFECVILGFDSPTEAHLYTIEQDGKYYLWDSPGFAYAGSGGFLAFLQIAKSRHTKQDPVSRTISLVYFAKKVSEMAEGVGKKTTDLFVLYPHWDDPNKMGDPDTALYLLYNPNRQALLSTLDKAFEDIQKFEEQKIEEISHLIDEALTPKEEAKSDDEQAEKKDDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN19</accession>
    <name>K0IN19_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component II</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpG</name>
        <name evidence="2" type="ordered locus">Ngar_c16710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16710"/>
    <dbReference type="EnsemblBacteria" id="AFU58604">
        <property type="protein sequence ID" value="AFU58604"/>
        <property type="gene ID" value="Ngar_c16710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1648"/>
    <dbReference type="HOGENOM" id="CLU_014340_1_3_2"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="21778" checksum="D0BAD0AFD09530AC" modified="2012-11-28" version="1">MKILVIDNYDSFVYNIAQILGELGAEPVVVRNDKITLEQVKEMNPDGIVISPGPGHPADRKYFGVCTDIIRELGPKTPILGVCLGHQGIVHAFGGKVINAKKVRHGKTSPIQYMQEDRIFENVANPFKATRYHSLVAEQDSIPDCLKVTAKALDDGEIMGIKHKQYPIEGVQFHPESVLTGEGRKMLQNFLSMVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN37</accession>
    <name>K0IN37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58694">
        <property type="protein sequence ID" value="AFU58694"/>
        <property type="gene ID" value="Ngar_c17610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17610"/>
    <dbReference type="HOGENOM" id="CLU_175245_0_0_2"/>
    <dbReference type="OMA" id="NSTYEDP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1759-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="10197" checksum="DEC69C7940DF54C8" modified="2012-11-28" version="1">MIKEKIKVNNRSYNVTINEQTQMYAMRLRRLYQQSYSDMDSFDEVSSEISSTVSNLLKHAVSPEVREDDMDGVIQQLLKMYEKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN92</accession>
    <name>K0IN92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58969">
        <property type="protein sequence ID" value="AFU58969"/>
        <property type="gene ID" value="Ngar_c20370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20370"/>
    <dbReference type="HOGENOM" id="CLU_1830506_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2035-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="137" mass="14950" checksum="66D45AC9F2CB532F" modified="2012-11-28" version="1">MKNYKRIGFVLAALSAGIIAAAGILHLEIAFEVMPTSIFAAGIFIAFGIPQIAWIIPTIKQLGTKWYIAGIAWNGALIGFFLMTLFPNPVTGIAIPPVTTDIAIEILQSTFIGLSALMVLYERKRKRLTEKERTGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC9</accession>
    <name>K0INC9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59154">
        <property type="protein sequence ID" value="AFU59154"/>
        <property type="gene ID" value="Ngar_c22240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22240"/>
    <dbReference type="HOGENOM" id="CLU_2285138_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2222-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11693" checksum="9F875D5E45FCA8E6" modified="2012-11-28" version="1">MKISELCKMVEDSIRSGRYPLDTETQRKLAPTLQVINRSDGEDLKRSNNIAIETRVQDLYVVSNYVHNIQHLPGVIELDVIDSFKMICRKLERLDHGIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING0</accession>
    <name>K0ING0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L37ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl37e</name>
        <name evidence="3" type="ordered locus">Ngar_c23840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23840"/>
    <dbReference type="EnsemblBacteria" id="AFU59309">
        <property type="protein sequence ID" value="AFU59309"/>
        <property type="gene ID" value="Ngar_c23840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23840"/>
    <dbReference type="HOGENOM" id="CLU_141199_2_1_2"/>
    <dbReference type="OMA" id="ECGSAKF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8509" checksum="30ED19CB24B092E9" modified="2012-11-28" version="1">MVKKGSTNLKGLGIKFGATVRKRYGKVHRTLHKKRRCPSCGSLRFGRLAVGIWQCPKCNFKIASGAYDIDLEKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI2</accession>
    <name>K0INI2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding domain of putative signal transduction histidine kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24961"/>
    <dbReference type="EnsemblBacteria" id="AFU59419">
        <property type="protein sequence ID" value="AFU59419"/>
        <property type="gene ID" value="Ngar_c24961"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24961"/>
    <dbReference type="HOGENOM" id="CLU_2021579_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2495-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="14517" checksum="7D179CB7BF61F3C8" modified="2012-11-28" version="1">MVRNAKRLELLSSNILEVSRIESNALKLQRETLDINEKVRVVLEDSRSFIPDDKKVLIVFEPYREPLFVQADRARMFEVLSNLVRNAIKFIEKEGTITVRVEKERHRLCPCRHQRYGDWHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0INV5</accession>
    <name>K0INV5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="5">HPPK</shortName>
            <ecNumber evidence="5">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="5">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="5">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mptE</name>
        <name evidence="7" type="ordered locus">Ngar_c31180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31180"/>
    <dbReference type="EnsemblBacteria" id="AFU60034">
        <property type="protein sequence ID" value="AFU60034"/>
        <property type="gene ID" value="Ngar_c31180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3096"/>
    <dbReference type="HOGENOM" id="CLU_093043_0_0_2"/>
    <dbReference type="OMA" id="HAHGDNM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="6">
        <location>
            <begin position="43"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="245" mass="26897" checksum="0E0840AEBA1AA32F" modified="2012-11-28" version="1">MKFADWFPYYQGIRAEFGYSTEKDQEAARILSEMIKSKALDPKVLQKKIKGKNIIVVGAGPSLEDEKTLKFIKKNKKSVKIAADGAVQFLIENKIKPDIVVTDLDGDAASLQKAEKGGAIMVVHAHGDNTAMLKKLVPKFKKLVGSTQVMPVENVYNFGGFTDGDRGVFLAEEFGAKKIVLVGMDFGESIGKYSKKKGKDAELKKQKMEAGKRLLEMLAKQSRSELADISKKPIRGFAPLAANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ0</accession>
    <name>K0INZ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32940"/>
    <dbReference type="EnsemblBacteria" id="AFU60209">
        <property type="protein sequence ID" value="AFU60209"/>
        <property type="gene ID" value="Ngar_c32940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32940"/>
    <dbReference type="HOGENOM" id="CLU_2985808_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3294-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6392" checksum="4CBB64C941AFCCB4" modified="2012-11-28" version="1">MSIYHISAVTLKVRDIKKSFNFYSKLPGFKLVYGGGAIDRFTTSEIGGSNMYLNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ3</accession>
    <name>K0INZ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60224">
        <property type="protein sequence ID" value="AFU60224"/>
        <property type="gene ID" value="Ngar_c33090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33090"/>
    <dbReference type="HOGENOM" id="CLU_1088270_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3309-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="28426" checksum="0C93B4C0B99C6937" modified="2012-11-28" version="1">MAATECYFIGLEKPDPVLFQQGLAWLIDNAAKSGGSAWIAVNQRESIGNIAKYPGFGRFAIFHKRGVNRTLLADCMIELVTRFSVPEDGRGRPMLVFHPTGDFLSALERVPNIQKILVIPFLAQEVDNWAKRNFAKDLDNPDLPSIYVDDIAITAFKHLRFAFTETPPQTPAQYRAALCQTLHILVQNGIRFEPQALQSALIQQCGWGPVSSKQVAELSEIFLVGQSPAGYDGRGPWEPDIMKLWKIEAAKTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ7</accession>
    <name>K0INZ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nitrous-oxide reductase NosZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c33290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60244">
        <property type="protein sequence ID" value="AFU60244"/>
        <property type="gene ID" value="Ngar_c33290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33290"/>
    <dbReference type="HOGENOM" id="CLU_1691619_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3329-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="168" mass="19022" checksum="0E4D422053E55516" modified="2012-11-28" version="1">MYMKKKRYEERQRSSRITRKRIITYGIIATAVSLISYLGYNAMIPVNGTTPVLGAPANHFIKATHSSSSGYTWVSIASAKVKGIRNTGGNVINPDYAFNKGELETFHVINEDYTTKSNHNFNIDEFNVHTKDLAYYESQTITFVADKTGTFEYYCTIHPEMKGEIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP12</accession>
    <name>K0IP12_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60319">
        <property type="protein sequence ID" value="AFU60319"/>
        <property type="gene ID" value="Ngar_c34040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34040"/>
    <dbReference type="HOGENOM" id="CLU_3263941_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3405-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="41" mass="4425" checksum="236FB16BBD9A8434" modified="2012-11-28" version="1">MALFHVTKAVAFEDYSLGQSVAGKNRFSSAETISTHAQQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP15</accession>
    <name>K0IP15_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34190"/>
    <dbReference type="EnsemblBacteria" id="AFU60334">
        <property type="protein sequence ID" value="AFU60334"/>
        <property type="gene ID" value="Ngar_c34190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34190"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3414"/>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3420-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="316" mass="35384" checksum="623C82A6BEF61063" modified="2012-11-28" version="1">MVKDILSLFTVPERTKSGYSFADTPVKISFKESNVVVYGVPLDITTSFGKGTSRGPEAIRRASARQIETFVLDEKADIYDLVGIFDLGDLKLPKAKKMRSIAKVLAYLDSSIPKVVASLRNDNKIPVMLGGEHTLSYYQLKALAKEEPVVIHFDAHRDMKPEYEGLKMCHTTPFYHLMEYIPGENLIQIGIRQADRQEDEIAAKSGVTTFDAWQVHDDIDAVADHLQRATAGKKIYISFDIDAYDLPYVPCTGTPEPFGLDPFQVLKLVKAISPSARLIGIDMVEVGLRNGDYREGALATQTLYRILSRPYCRAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7J4</accession>
    <name>K0I7J4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LOR/SDH bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02630"/>
    <dbReference type="EnsemblBacteria" id="AFU57211">
        <property type="protein sequence ID" value="AFU57211"/>
        <property type="gene ID" value="Ngar_c02630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.258"/>
    <dbReference type="HOGENOM" id="CLU_056125_0_0_2"/>
    <dbReference type="OMA" id="GHKHHIY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-263-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12144">
        <property type="entry name" value="SDH_N_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005239">
        <property type="entry name" value="CHP00300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007545">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043009">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04455">
        <property type="entry name" value="Saccharop_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00300">
        <property type="entry name" value="TIGR00300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharop_dh_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="415" mass="45514" checksum="F0A73F16942FF8CA" modified="2012-11-28" version="1">MADNRFEQEIEVKGHLIDSMILTRIFDSIMDMQGDFQVLEFTVGKKKGDPSYARLLVKGKSKTHLESILEQVFREGAQPVSVQEVRLEPAPKDMVMPDDFYSTTNNATQVYYGGQWIDVQNMMMDKCIVVDTRRKTAECKMVRDIVKGDLVVVGERGVKIIPLERPREGVDIFQFMSSASSSERPTQHIARKVASDIYSTKKEGGKIVVVSGPVLVHSGAAEALASLIRMGYIDGLLAGNALAVHDVENALLGTSLGMRVKDGTLAIRGHRNHMEAINEVFKAGGLRAMVDKKILKSGVMYECIKNNVPFVLAGSIRDDGPLPDVVTDVVEAQRKYKEIVKGARMVLMFSTMLHSIAVGNMLPASVKVVAVDISQPVVTKLIDRGTAQAIGIVTDVGAFLPIVVEHLKQIANKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7T9</accession>
    <name>K0I7T9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57331">
        <property type="protein sequence ID" value="AFU57331"/>
        <property type="gene ID" value="Ngar_c03830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03830"/>
    <dbReference type="HOGENOM" id="CLU_838415_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-383-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="331" mass="38993" checksum="050B3322B8CF0BF3" modified="2012-11-28" version="1">MKTDFKVALEQYFSKEVNRRYSLPIIQNLTQQHMHGDIRELKTDPDNILKICNKLIQDSLSDKRYTASVVPTIISPQMARNFYLKDEKEPSENELYEFLYLILTGVYKGPYIVNITNTRSQLIDNFRQDLIDKQNIVFDSKKAKEPLGMKLAVFNTLFANERFRPPMTEFTFPFLVVSSFVYWIKERTTDRAELIAQLTQTGQKDLIENDLEINDDTTLVLFVLGRDKKKVYYFSQLRRLIIRWFKGYLQNEENYPSVVNALFSLYISNKNYRDLSIDLLDKLLYYFLDGYVNGELLDKLMLLKLDHDLKQKKVFGMNSAKQFFENLSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8E1</accession>
    <name>K0I8E1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57546">
        <property type="protein sequence ID" value="AFU57546"/>
        <property type="gene ID" value="Ngar_c06030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06030"/>
    <dbReference type="HOGENOM" id="CLU_023853_0_1_2"/>
    <dbReference type="OMA" id="SMDPIEE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-601-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="292" mass="33878" checksum="D156435BC7D75D17" modified="2012-11-28" version="1">MEFVDSSVVEQIEMKMIRPSQFAIRDKFLKNDQEFETLVNSIREHGLLQPILIRPFSNGFEIVAGHRRFQACRTLRWRFISAKIRELSDKQAYEIQLTENIQRKSMDPIEEAEAFRRYVIDFGWGGVSELARKIGKSEEYVSHHIQLLKLPEEIKQKVASKSLNISQAIEIAEVPSDKQPKLLSHIMNNNNLTVRQIRELKSALRQADDIDDDMLVISSRTRSKSFTIAKKTSLTLRIALTRLDNLINEVHTTVEPDQRAELVDFLMSVRLRIHSMIDESIRFKSKINSDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9C8</accession>
    <name>K0I9C8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57941">
        <property type="protein sequence ID" value="AFU57941"/>
        <property type="gene ID" value="Ngar_c09990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09990"/>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-997-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="83" mass="9621" checksum="8B2ED924C8097513" modified="2012-11-28" version="1">MTCKGICVRHRAPKPTNAGRYSTGQKRCQVCEIFIKWDGLWCPCCGYRLRTKPRNLKYKAKLREKMIHGKSLLAKIPLAIEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9P0</accession>
    <name>K0I9P0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58036">
        <property type="protein sequence ID" value="AFU58036"/>
        <property type="gene ID" value="Ngar_c10940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10940"/>
    <dbReference type="HOGENOM" id="CLU_2930310_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1092-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6924" checksum="80962F156B714340" modified="2012-11-28" version="1">MLNSTPAATTFRQIPNLPLSSCKKLGISEDQCYDAVTILKEEEDNKPKKWYRRIQQPTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9Y2</accession>
    <name>K0I9Y2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58136">
        <property type="protein sequence ID" value="AFU58136"/>
        <property type="gene ID" value="Ngar_c11960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11960"/>
    <dbReference type="HOGENOM" id="CLU_2140280_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1194-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="12880" checksum="E00B0DA8A55C85D6" modified="2012-11-28" version="1">MSHRLEKNTDTKYHDYKEPKMSRHLSAGDYKRRQENTRSDIQSEDAESTWNIARESESNKNRGSFANEQQSVENITKQNKKSLGSSVASEIRKGKRTEETMLGSVSNPKEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAI4</accession>
    <name>K0IAI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13890"/>
    <dbReference type="EnsemblBacteria" id="AFU58326">
        <property type="protein sequence ID" value="AFU58326"/>
        <property type="gene ID" value="Ngar_c13890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13890"/>
    <dbReference type="HOGENOM" id="CLU_114385_0_0_2"/>
    <dbReference type="OMA" id="DYWGAFD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1387-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="UPF0113_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="UPF0113_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="95"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="175" mass="19907" checksum="9088480C5BBE557E" modified="2012-11-28" version="1">MNTYRRPSREERTRINRALDRWGTFEFFKDKSLMIQENDDGGSKAVCFVPGELEPFMRMQPPYLAGLVIGELKKQFVPSMAGADLFARSGKRNEFYIVVNENAEKLVLYGRDIMGESIVEASDMLDENELVIVLNRRLEAIGIGRTRFAGRSLLQKGRITVTTVADAGYYLREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAN2</accession>
    <name>K0IAN2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blue (Type 1) copper domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c14500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14500"/>
    <dbReference type="EnsemblBacteria" id="AFU58386">
        <property type="protein sequence ID" value="AFU58386"/>
        <property type="gene ID" value="Ngar_c14500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14500"/>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="OMA" id="HCQPHPW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1448-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="154" mass="16784" checksum="707FD3F8EF7F91E2" modified="2012-11-28" version="1">MANHAGGISIITFIVAVAVSMGYYQFVYVPQANARPVLPEEIVNPPEVTNVQIVEGSALESQTRNFVPKDARAILGLSNKVVWTNNDGTSHTVTSDDGYHDQLSGAFASTEQLGALINPGETFEFIFTKEGEYPYHCDPHPWMQATVVVVPNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAW6</accession>
    <name>K0IAW6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.49</ecNumber>
            <ecNumber evidence="2">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiD</name>
        <name evidence="2" type="ordered locus">Ngar_c15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.49" evidence="2"/>
    <dbReference type="EC" id="2.7.4.7" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15420"/>
    <dbReference type="EnsemblBacteria" id="AFU58476">
        <property type="protein sequence ID" value="AFU58476"/>
        <property type="gene ID" value="Ngar_c15420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1506"/>
    <dbReference type="HOGENOM" id="CLU_035788_0_0_2"/>
    <dbReference type="OMA" id="AWIEIPA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="444" mass="48055" checksum="049EBA3A985C6A99" modified="2012-11-28" version="1">MKIALSIAGSDSGAGAGIQADLKTFSALGVYGCTTITAITAQNTKRVAEIFEVSPAMVEQQIRSVMTDMPPDAIKIGMVYSRQIIDVIYQSLKKSKVPIVLDPILAAGTGASLLRDDAFDPFVSKLMPICTLVAPNRIEAEKLSGMTIKTESDSIEAARKIKKLGAENVIVKGGHFGASSVTDLLLDRRGRLTEITNPRIEIKESHGSGCNFSSAITAYLAKGASLEDACRMANEYVHIAIKNAVRVGRGLPVTNPLSAIYRDASRYRVIAELQAAVEQVSTLDGFYKLIPETQTNFAYALPDATDISEVAGVRGRIVRIGNTAVPASYIEFGASRHMASAIIGYMQVNPAFRSVINIRFNDKLVNVCKSLFTVSSYDRSKEPKGIKKREGSSVSWGTMQALSKNPRADIIYHRGDIGKEPMITVFGRNPGEVVTKIKAILENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBR8</accession>
    <name>K0IBR8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58701">
        <property type="protein sequence ID" value="AFU58701"/>
        <property type="gene ID" value="Ngar_c17680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17680"/>
    <dbReference type="HOGENOM" id="CLU_2712981_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1766-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9949" checksum="8B6518A06FD6A6E5" modified="2012-11-28" version="1">MFVVKRLGKNGMWSAVSLIDQNGSFRGEAKFETRDEAEEYMAEYLKRMKSRQRISPEGYGEIKVFDESKQDKEKSKPSSKGKKKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBR9</accession>
    <name>K0IBR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c17730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58706">
        <property type="protein sequence ID" value="AFU58706"/>
        <property type="gene ID" value="Ngar_c17730"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17730"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1749"/>
    <dbReference type="HOGENOM" id="CLU_044464_1_0_2"/>
    <dbReference type="OMA" id="RCNHASN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1771-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="293" mass="33646" checksum="2FCFCF54AD0E4DA4" modified="2012-11-28" version="1">MEIIYDYPLYRPPSEANSMIFQVTLGCSFNKCSFCNMYRTKEYSERPWDEIKAEIDMVAKFYPDTRRVFLADGDALNLPKDRMIQILQYLYSKFPELERVSCYAMPMNLLKKKDDELEEMRAAGLHMLYVGIESGSDIVLKKVTKGATYRTIVQACQKAKRHGYILSCMVILGLGGKTYTREHIADTARILSETAPDYVGALTLHLEHGIYNEFMTKFGEPFIGLDDMGVLDELERLVANFNPKTRVVFRANHASNVYSIGGTMPDDKDKVLTLVRSLKSHPEMLKPKFLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBV8</accession>
    <name>K0IBV8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="3">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c18380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + GTP = CoA + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18380"/>
    <dbReference type="EnsemblBacteria" id="AFU58771">
        <property type="protein sequence ID" value="AFU58771"/>
        <property type="gene ID" value="Ngar_c18380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1820"/>
    <dbReference type="HOGENOM" id="CLU_120795_1_0_2"/>
    <dbReference type="OMA" id="AIYDHKT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1836-MON"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006533">
        <property type="entry name" value="UCP006533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="166" mass="18040" checksum="AFD85F9B3849B932" modified="2012-11-28" version="1">MPINENDARLLKQPFGTLVPDKQVTKRKVASVLKGVKQVIAVGDATTERLVSFGIKPDIAVIDGKERRSKRSYSASYSAKELHCINPAGTISKEAVQVLQDALRMPSPVRVLVDGEEDMLALPLFTMAPEGSAVLYGQPLEGLVIVKITSAKQKQAKDLMDRIGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC01</accession>
    <name>K0IC01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57080">
        <property type="protein sequence ID" value="AFU57080"/>
        <property type="gene ID" value="Ngar_c01300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01300"/>
    <dbReference type="HOGENOM" id="CLU_1754760_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-130-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16331" checksum="7AB9CA238F8DC88E" modified="2012-11-28" version="1">MGLLRRLPLPLLHSWSKFGREAEYVVALYLKSMGWDIALSPASRGPADIVATCCCSGNSRSTWFIQVKASAGIPRLRGYEVRRLKELAASKNGLPMVSTFQPSFPGGFSTGNYSITFYLLDSWQELDPMEFLERGGGCTSLRSSARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC26</accession>
    <name>K0IC26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58901">
        <property type="protein sequence ID" value="AFU58901"/>
        <property type="gene ID" value="Ngar_c19690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19690"/>
    <dbReference type="HOGENOM" id="CLU_2490572_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1967-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="9898" checksum="CFD3B8A0E2FD4780" modified="2012-11-28" version="1">MFCCAGLFGGFIAGAATGILWVPFVTAAAGAGGGLLIDIKMFRALNKKNDSKESHLGRMCCDALRLSKKKRSNLRPLKLPQQLCTKIVTMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICA1</accession>
    <name>K0ICA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20590"/>
    <dbReference type="EnsemblBacteria" id="AFU58991">
        <property type="protein sequence ID" value="AFU58991"/>
        <property type="gene ID" value="Ngar_c20590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20590"/>
    <dbReference type="HOGENOM" id="CLU_075000_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2057-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="278" mass="30511" checksum="C78385A051E7B1AF" modified="2012-11-28" version="1">MNPRPNRKNSNNLPVVSDGYTKVLPVTNQKIVLERPVLIAGFPDSGMIGSVTINHIIEQLKMHQIGYIESQHVMPAAIFIGKRFRHAFRIYANDSGTVCALICEVPVTARGTYSIINTIVDWCMNAKVSEIVVLGGILPANFSPPYLLERKAMLLRNELAEKPSAQSPNPADSLGMAVPDDAIIVGLSGSLLSVCAARGLGCTALMIPTMVESPDPEGAAIVLEALPKILPGLKVDTSSLRQKVEMIKKHLEEFLKMHRQQLQDYERSASREAERIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICF8</accession>
    <name>K0ICF8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative menaquinone biosynthesis methyltransferase UbiE</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ubiE2</name>
        <name evidence="4" type="ordered locus">Ngar_c21300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21300"/>
    <dbReference type="EnsemblBacteria" id="AFU59061">
        <property type="protein sequence ID" value="AFU59061"/>
        <property type="gene ID" value="Ngar_c21300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21300"/>
    <dbReference type="HOGENOM" id="CLU_037990_9_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="29140" checksum="5A546D837291811E" modified="2012-11-28" version="1">MRCQFTKYKPSNIGARPLIYFYSMHNSKYGYISTTYMLLVHEGHASARRFFTPANAGSYDSVVRLATFGQDSVWKRKVVKAVGSRKSVLELACGTGVLSSMFLGAGRSVVGIDLTFEYLRASRRKPQMAAVAQGTAEVLPYRNESFDAVASSYLAKYVDIEKVIDECWRVLKPGGIIIFHDFTYPSGIMRSLWNAHFAVLRLAGRLVTSWRTVFDQLDSVIKNSDWVNKTSDVLYIRGFQNVDCKYYTAGTAAIVSAEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICM6</accession>
    <name>K0ICM6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59121">
        <property type="protein sequence ID" value="AFU59121"/>
        <property type="gene ID" value="Ngar_c21910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21910"/>
    <dbReference type="HOGENOM" id="CLU_2447766_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2189-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="10273" checksum="E05FD104877ACEED" modified="2012-11-28" version="1">MLARFFEVGETRDKGKGLFAKELVPKGTIVFFECKQCKRISKDDLLAEEEKAFVQKYGYTKADGSYLVPCDEIIYFNHSCNANILWPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICQ8</accession>
    <name>K0ICQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c22210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22210"/>
    <dbReference type="EnsemblBacteria" id="AFU59151">
        <property type="protein sequence ID" value="AFU59151"/>
        <property type="gene ID" value="Ngar_c22210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22210"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2200"/>
    <dbReference type="HOGENOM" id="CLU_067676_4_1_2"/>
    <dbReference type="OMA" id="YSTLCMA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2219-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="22334" checksum="0615AD1A570A1A24" modified="2012-11-28" version="1">MDGRILRVISKLDRQSNMERSGKARVPSGQEMLAITADTGMFFSILLKAIKAKRVLEVGTSVGFSTLWFADAVGKKGKIVTIEMDPLKVARAEKNFKQAGIEKLIEIKQGVALDVLRTLKCRFDFVLLDADKENIIKYFDLILPLVRVGGIIAADNMLFPPHYRPMMKKYARHVQSRRNVQSVTVPIGMGEEVTIKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID29</accession>
    <name>K0ID29_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59286">
        <property type="protein sequence ID" value="AFU59286"/>
        <property type="gene ID" value="Ngar_c23610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23610"/>
    <dbReference type="HOGENOM" id="CLU_3178702_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2359-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5050" checksum="2251C10CE84C0582" modified="2012-11-28" version="1">MGASQAEPRHECRVCGRMFKTLEDLMMHNREAHVGGTTATTTGQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID62</accession>
    <name>K0ID62_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57600">
        <property type="protein sequence ID" value="AFU57600"/>
        <property type="gene ID" value="Ngar_c06570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06570"/>
    <dbReference type="HOGENOM" id="CLU_2712960_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-655-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="7430" checksum="2C51391D95E6661F" modified="2012-11-28" version="1">MIGSGVLEVNNMLNKGGGGCPSPETGGTGFYSGCDISLLYAGIIALIISDVALIVFSIRPEIIRAFPSRVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID72</accession>
    <name>K0ID72_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59336">
        <property type="protein sequence ID" value="AFU59336"/>
        <property type="gene ID" value="Ngar_c24110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24110"/>
    <dbReference type="HOGENOM" id="CLU_034350_1_0_2"/>
    <dbReference type="OMA" id="WSHTNIN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2409-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="511" mass="56158" checksum="460891A0879CC9B8" modified="2012-11-28" version="1">MPRDIKSLTCGAGLRIKYVERQVIYVQAGRQKILAFGFASVLVFSIIAIGLPRQEAFADGLTQEMFSASLGDRQAELLVRVNPPILTDASRDEAYMLLRLYDANNNQTIRFTTFIISVEKGIGENAEEIFTDTFHTESGLLQLKVQPAEGPVQIFGTREQFLNAWVADPGGTVNIRGPMFLEGGIYHLRIDILGIDNIRNLFPPDQIPRFDSWLSVGDIFTQSVEYQGQSYDTTIISYYDQVQDFNFDAQRQQFSWSMPFDWDTSRLRQTNIFVHEEIKIPKSLAGIGDATSFAATVNGNPISGRMLAVDPYSSENELILHYLVNKNDILNMAGKVPDGSSEMTFTLAPATGENAQTTGEMLTDSGNVNVLVEWTPSQLSAGTDSTLTLAFADGFSGQRITDDVNYNLKILDSNGTDVYSRSGLVAEGGTGTQTIDFPSNENYRMEVQITGIVRDGQPVDQTRNGIARGIVVVPEFPAGALVAAAGVIGAVLMMQRFASKKCRACDEKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDC0</accession>
    <name>K0IDC0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cupredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c07170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07170"/>
    <dbReference type="EnsemblBacteria" id="AFU57660">
        <property type="protein sequence ID" value="AFU57660"/>
        <property type="gene ID" value="Ngar_c07170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07170"/>
    <dbReference type="HOGENOM" id="CLU_1500326_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-715-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="179" mass="18439" checksum="FB42A4D03E2C1D2E" modified="2012-11-28" version="1">MYMPIKPGKVAFPIIIALGAVTGILSYILFSQAAPGPLFTSGQFFEPTPAGIPTGEIKEGQEGETATAGAGQESGANTTGGDQTAAIPPDAVTISILQGASVQGNPAYDPETAQASIGRTVVWKNDDSVPHTATSGKLFDSSIINPGESYSIAAEEIGAGEHEYICTLHPYMKGTIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDF4</accession>
    <name>K0IDF4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25080"/>
    <dbReference type="EnsemblBacteria" id="AFU59431">
        <property type="protein sequence ID" value="AFU59431"/>
        <property type="gene ID" value="Ngar_c25080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25080"/>
    <dbReference type="HOGENOM" id="CLU_632567_0_0_2"/>
    <dbReference type="OMA" id="ANVGTQD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2507-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="470" mass="49413" checksum="B5323CB21050B83C" modified="2012-11-28" version="1">MMIVNSTIIFALLASMVLIPVAAYAQEGGPSREDIISAYYSGPVYLDSYWTSGLNSSESTTELDVAPGDGASTLAVVLINRGPSDISGITGQLTLPSGFQATGKPAGSLATATFNQIVKVGNTFTLFFDVDVLDTASIGEHTAQLSVDYSRFFETGVPRNASMDVPFRVTGKAIINVSGISSGDGDASNQIVAGKIEDYNISVANKGTAPITNVVVTLVSPSESVKILGNSKWTIQSIGEDSQVDLPTRVFAANSLIGNPASFDVTVEYSSNGQSNTETFTLGIYIAGEISIRAYDLAINYIGGTPNIVGSLLNEGNTVALFTTIEVTGAENLVSDLPPQQYIGDLEENSPLPFSIPINVNSRAGAGTYAISLKVSYKDDLRETHMLDVNSEVQFAPEQPADESSQGPDIASISLMPVGIGVAAAAAIAGVTVARRRKKSALKRTFQAGKADDDDIESVLDSHSSKQDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDH1</accession>
    <name>K0IDH1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 12" type="primary">gatD</name>
        <name evidence="12" type="ordered locus">Ngar_c07470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07470"/>
    <dbReference type="EnsemblBacteria" id="AFU57690">
        <property type="protein sequence ID" value="AFU57690"/>
        <property type="gene ID" value="Ngar_c07470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.721"/>
    <dbReference type="HOGENOM" id="CLU_019134_2_1_2"/>
    <dbReference type="OMA" id="RKNHTSR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="SSF141300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase" evidence="9">
        <location>
            <begin position="78"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="10">
        <location>
            <begin position="297"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU57690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="421" mass="45313" checksum="3540ECC00EC4F8E3" modified="2012-11-28" version="1">MEVGDNVKVATNDGEMSGVLMPRYESASEDYIVIKLKSGYNTGIQVGRIKSITKLQKSEPAATTARAPETTEDKGLPRIALISTGGTIASKIDYRTGGVHAALSASELYASVPELANHASIDPEVLLSEYSENLRPDHWTMIADKVAEKVRSGRYRGVVVSHGTDTMHYTAAALSFALQDLPIPVVLVGAQRSSDRPSSDAALNLLGATVFAAKSEYAGVFVAMHASTSDDAIACHIGTRVRKNHTSRRDAFESIDVTPVALVRNNTIEMQKSEIKLAKRSEGSGSLATVKTKFDGKVALLKYHPGFDPSLIEHAAKAGYRAIILEGTGLGHVSKECFPALRKVVDSGMMVCMTSQCIWGRIRMTVYDTGRDLLDIGVVPLSDMISETATVKAMWALANSKDPKKTMQENLANEISSSIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDJ0</accession>
    <name>K0IDJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57725">
        <property type="protein sequence ID" value="AFU57725"/>
        <property type="gene ID" value="Ngar_c07830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07830"/>
    <dbReference type="HOGENOM" id="CLU_157016_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-781-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13275" checksum="23B1B64D88910EA9" modified="2012-11-28" version="1">MDYSDLCQKVDFLGQNLVCVIVVKKGKLVASKVKPGLEALNEKRFADMFTQVQIMVGVAQTAEDILGGMEHVKVRYGNGLDVYLFPLETPSEKTILVVAVMRPYNTDDLLEKIVNVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDL0</accession>
    <name>K0IDL0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hemolysin-type calcium-binding repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57765">
        <property type="protein sequence ID" value="AFU57765"/>
        <property type="gene ID" value="Ngar_c08230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.789"/>
    <dbReference type="HOGENOM" id="CLU_1122647_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-821-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="247" mass="25591" checksum="30DBBB4BB08F8E7C" modified="2012-11-28" version="1">MMQSKISSTTTALLAGAATIGALAFLILFAPAANVLAAGKFGNSGNNPMSGTNGADKIYAEGGNDKVNSGAGNDKVFGDLGSDTIHGGDGNDRLYGQGGNDYVYGDDGYDFVFGQLGNDHVYGGLEEDYVNGKEGDDVLYGGEESDQIFGEKDNDGMYGEGGNDRMYGGGGADMVDGGPGNDYIEGGEGNDRLYAGTGADTVNGGSQDDYISTMDGDDIVYCGPGYDTVNKKYSDTKYYSCEKFGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDW7</accession>
    <name>K0IDW7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59576">
        <property type="protein sequence ID" value="AFU59576"/>
        <property type="gene ID" value="Ngar_c26550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26550"/>
    <dbReference type="HOGENOM" id="CLU_2712973_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2655-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="7858" checksum="5AB240B6CCEF174F" modified="2012-11-28" version="1">MANGVLVILAASLSFALLPQIAFTDAYAKWPIHNADHILGQFMMLLIVPLGVAIVVLGVWAMRVRQDQIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE44</accession>
    <name>K0IE44_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01380"/>
    <dbReference type="EnsemblBacteria" id="AFU57088">
        <property type="protein sequence ID" value="AFU57088"/>
        <property type="gene ID" value="Ngar_c01380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01380"/>
    <dbReference type="HOGENOM" id="CLU_101753_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-138-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="162" mass="18013" checksum="7D9B21B036532714" modified="2012-11-28" version="1">MKAKKKPGKIQRRDIYYIAGAVAVLAVAIALIGSREVPKPEIMAHGEQVAYHHHVRFEYYLDGQKQVVPANIGVPIDQNHPLGRYGVAGIAPIHTHETDGLIHMESKDEEKPFTFGEFLELWGLDLTDKQAALLANGERITDMEGYVLKDGASLRLEVTTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE78</accession>
    <name>K0IE78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycoside hydrolase family 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01640"/>
    <dbReference type="EnsemblBacteria" id="AFU57113">
        <property type="protein sequence ID" value="AFU57113"/>
        <property type="gene ID" value="Ngar_c01640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01640"/>
    <dbReference type="HOGENOM" id="CLU_2476115_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-164-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="10031" checksum="E9A3EE325FECE808" modified="2012-11-28" version="1">MAWTILSKNINWMIYYGLLQNGYDREAEIIRDEIIKMVTKEGARKYYNLFTGEGSGGKNFSWTAALTLDLFYRQSGKKTPLDKILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEB2</accession>
    <name>K0IEB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58115">
        <property type="protein sequence ID" value="AFU58115"/>
        <property type="gene ID" value="Ngar_c11750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11750"/>
    <dbReference type="HOGENOM" id="CLU_2911648_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1173-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="7041" checksum="0677EEDD79D68895" modified="2012-11-28" version="1">MYYSFYGIGVNDTQQLAIMTQGKKHAPSKTGDHNLDVERMQYEKDKENIPATVTDYVNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IED9</accession>
    <name>K0IED9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58140">
        <property type="protein sequence ID" value="AFU58140"/>
        <property type="gene ID" value="Ngar_c12000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12000"/>
    <dbReference type="HOGENOM" id="CLU_3094228_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1198-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5829" checksum="B489B3D1D5D5F41C" modified="2012-11-28" version="1">MYVISMNQVEKSIVEQSIALLNNSFSAEDQTANKMVRDAIERLEGLLERKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEE3</accession>
    <name>K0IEE3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57163">
        <property type="protein sequence ID" value="AFU57163"/>
        <property type="gene ID" value="Ngar_c02150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02150"/>
    <dbReference type="HOGENOM" id="CLU_1943922_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-215-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14619" checksum="250731C64D8ADEFD" modified="2012-11-28" version="1">MLSGVTGLGVGVRDEDEDKMQLLLDSLRPAIVGLIESCNYEVPDILTKIDYAIIKELIKKPRIEVLDIAKAVDLARDCRENDREDDEKSLLEFSININPSAMKGQIVFFLPVRAERQFYPGCWKGYLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEF9</accession>
    <name>K0IEF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59721">
        <property type="protein sequence ID" value="AFU59721"/>
        <property type="gene ID" value="Ngar_c28000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28000"/>
    <dbReference type="HOGENOM" id="CLU_2968572_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2800-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6445" checksum="63A77359DF38CD6A" modified="2012-11-28" version="1">MTEGNSTSNDKTIADIRSAILQGKYRISDEFLNLVLAGFLQIAITVEPLDMLTVCERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEG8</accession>
    <name>K0IEG8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4443 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c12250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58165">
        <property type="protein sequence ID" value="AFU58165"/>
        <property type="gene ID" value="Ngar_c12250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12250"/>
    <dbReference type="HOGENOM" id="CLU_114386_0_0_2"/>
    <dbReference type="OMA" id="LEYEGAC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1223-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029349">
        <property type="entry name" value="DUF4443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14544">
        <property type="entry name" value="DUF4443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4443" evidence="5">
        <location>
            <begin position="109"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="23221" checksum="FEA2D4CEC968CFFA" modified="2012-11-28" version="1">MYIRALEKVASRYAPSRALSFDVVHVLAALQLIKTNGRTSRDTLSNNLALGEGTVKTLVKHLKMHALVQTSNGGTKMTAKGESICEGLLSAMPSELSLPKCSVALGRFNYAVLVREFGFAVRSGIEQRDAAIKMGATGATTLIFKEGKFVMPASTHDSLKKEPQVRRMLVEKLRPKEGDVVIIGSADSSEKTAELAAKNAALLTIFSHEKHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEI0</accession>
    <name>K0IEI0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">50S ribosomal protein L7ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpl7ae</name>
        <name evidence="9" type="ordered locus">Ngar_c28310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28310"/>
    <dbReference type="EnsemblBacteria" id="AFU59751">
        <property type="protein sequence ID" value="AFU59751"/>
        <property type="gene ID" value="Ngar_c28310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28310"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2796"/>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_2"/>
    <dbReference type="OMA" id="KPFYVRF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_L7Ae_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="8">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="12688" checksum="67BA9878EDC21992" modified="2012-11-28" version="1">MEVSKDLVNAVYEAVRVAKQSGKVRKGTNETTKAVERGISKLVVIAEDVEPPEVVAHLPILCEERNAPFIFVPSKQQLGMSLGIDVGSAAATIIDPGEAQHIVEQVVTSIGNLKGAAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEN1</accession>
    <name>K0IEN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58210">
        <property type="protein sequence ID" value="AFU58210"/>
        <property type="gene ID" value="Ngar_c12700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12700"/>
    <dbReference type="HOGENOM" id="CLU_2695892_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1268-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8247" checksum="A720AA87FE17BD69" modified="2012-11-28" version="1">MQDDLSGRILLVIVDIYDVCVWAQQVLRAAIRGPDMTSDNLTPAMERIADFCELVGYSEFGRNIPKTNNMNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEP5</accession>
    <name>K0IEP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59826">
        <property type="protein sequence ID" value="AFU59826"/>
        <property type="gene ID" value="Ngar_c29070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29070"/>
    <dbReference type="HOGENOM" id="CLU_1269966_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2907-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="25048" checksum="2BFDF3010C9835CE" modified="2012-11-28" version="1">MTKACIIDGCKNKGTIARKVGIFKELDDFTTVAYVCSAHKKRLKSGDSLLRFNFKDYSKLLLKDSNKKASETIDYIVEQAALDDRLQSVQLTIDAATHYARLADAKFLFGFYYAALFIYSSFKGFDTNVVRQKRVKEIRAKMSLKEPYPEREHPSIANEPTDICKCGHQEIMHEFGQPRGECYTCLCPRYEYEQRLSYTEVSDLGTLLYRELKKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEY4</accession>
    <name>K0IEY4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57358">
        <property type="protein sequence ID" value="AFU57358"/>
        <property type="gene ID" value="Ngar_c04110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04110"/>
    <dbReference type="HOGENOM" id="CLU_3338591_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-410-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="37" mass="4054" checksum="5B43B4F2A09D9595" modified="2012-11-28" version="1">MVCVACLIDTRRYAMVGWVIVGALLSGYGYMIITSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF27</accession>
    <name>K0IF27_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57408">
        <property type="protein sequence ID" value="AFU57408"/>
        <property type="gene ID" value="Ngar_c04620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04620"/>
    <dbReference type="HOGENOM" id="CLU_3148091_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-461-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="48" mass="5431" checksum="A8A883080F5AA065" modified="2012-11-28" version="1">MKATLFGVLEKLNIATTWSRAIILSLAQAIMDICHLGKKLREYTLPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFD7</accession>
    <name>K0IFD7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">Ngar_c06000</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06000"/>
    <dbReference type="EnsemblBacteria" id="AFU57543">
        <property type="protein sequence ID" value="AFU57543"/>
        <property type="gene ID" value="Ngar_c06000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06000"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.573"/>
    <dbReference type="HOGENOM" id="CLU_014319_0_0_2"/>
    <dbReference type="OMA" id="VAYSSWY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-598-MON"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="752"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFU57543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="923" mass="101657" checksum="D18C1EBDC79BF930" modified="2012-11-28" version="1">MFRAGSFEFQTRHLLVIAVLALAFTSALIMRFYPVKYGFYLNEFDPYFDYRATKYIVDNGLDAYWNWHDTMSWYPEGRDIPATSQSGLHITTAVLYSAFGGGSDLLDFTIVFPAVIGSLTVIVIFALVRVLGNTSAGLFSALLFAFSPAIIQRGNLGWFKSEPLGLFFGILAAYLFISAIKHKEIKYAIPKAVAGGLILGLANASWGGIQYFSIPIAIFFIALPFFRRDLTIPMYVAIAFTVFTLISAAAFPRPGMSFVLGLPGLGMIGSTIFLVIAHFLKRFSRSQVQLRNTAFLLIAFVAASVGVIATEAYLSPSFRYLNAVFPFLSSQNALVESVAEHFTPTVADYFVDFSVLIMFAGLGAWLAFRRRDDMSIFALIIGITGVYVSATFARLLVFASLGIIVLAGLGLYEVTRSIMAHRQATATPSVTQRPTAATREERRKIEFAGRGHPASGQAVRIAYTVVIIMMLSIPMFFPSNSNWLSSADSPAAIANGGTGFRTQTNDWTDALNWIEQNTEPDAVIASWWDYGYWITTLGNRTTLADNATINSTRIETIAKMLISDEQAGLKIAQDLQADYILVYTVAQVRFLGQTNNTETGATEQVPIYTLGQGGDESKKQWFMRIGGFDESKYIESDGFTPTPEFWNNTLLGKLFPFEPSSYVQLSDGRVASQPQPEWEPGLTGLYTQHIKYPTDGGSDQPLHLVYASPSFENEENIMFGVFIYKVNHDYVPNPQGDPYAEPEPTTANMTTSNEIAIINTTQGPIEIEFFPKEAPKHVDNFIKLANEGFYDGTLFHRIVPGFVIQGGDPNTKGDDSDRSTWGQGGPGYTVNAEFNDIPHTRGIVSMARAQDPNSAGSQFFIVLDDNENTRALDGKYTVFGKVISGMDVVDKIAALQTTMVGQTPQPANPEEARIISISIRESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFH0</accession>
    <name>K0IFH0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiA1</name>
        <name evidence="3" type="ordered locus">Ngar_c06350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06350"/>
    <dbReference type="EnsemblBacteria" id="AFU57578">
        <property type="protein sequence ID" value="AFU57578"/>
        <property type="gene ID" value="Ngar_c06350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06350"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.612"/>
    <dbReference type="HOGENOM" id="CLU_056590_0_2_2"/>
    <dbReference type="OMA" id="FIDICDT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="243" mass="27337" checksum="5800857B948B1118" modified="2012-11-28" version="1">MYAGLQETNWIPRSFQEAARNLAKETVERFVKPDQVVGLGSGPMAAAIVREMANFDRKDTLECIPTSFQIKLEAECSGLKLVGENRMPEVDVVFDGADEIDARFNMIKGGGGALSREKIVHSAAKKIVIAAESTKFVPTFSWPVPIETHPFAVHVVRKKLEEVGGRPKMRMLREGYPYVTENGNFILDTEFDFPPSSDIRRQEVELKSIAGVVEVGLFTRRADTYYYYYKAKEDSSFETIENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFK2</accession>
    <name>K0IFK2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">Ngar_c16570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16570"/>
    <dbReference type="EnsemblBacteria" id="AFU58590">
        <property type="protein sequence ID" value="AFU58590"/>
        <property type="gene ID" value="Ngar_c16570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1632"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_2"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="309"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="391"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="195"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFU58590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="542" mass="59851" checksum="AD623A3164BADDE2" modified="2012-11-28" version="1">MQSKSPNGSKFIFVTGGVMSGLGKGVITSSTAKLLQLAGYKISCVKIDPYVNYDAGTMNPVAHGEVFVTDDGGECDMDIGNYERFIDIAMTKDHNITTGRVYMDVIRAEREGKYLGQCVQIIPHVTDAIKNTLRKIASDEKLDIMVVECGGTVGDIESLPFLEAFRQMELELGQSNTLFIHVTLAPVLDVVGEQKTKPTQHSVQELRRIGIQPDILAVRCKMPLSDDARRKISLFASVEQKCVISCHDAPSIYKVPEVLESQGMLKAISERLALRRSTPQWGDWKAIAESFSKYGGSVRIAVVGKYVTLPDSYVSIYHALSHAGASIGKKVEIQWIDSEKFENRGQQSLSMLKNFDGILVPGGFGKRGSEGIIGAANFARANNIPYLGICFGFQLAIVAFARHVCKLGDANSTELEPNTKNPVVDFMPEQRNIHDMGGTMRLGAHDIAINPKTIAAKVYGSTAIRRRHRHRYEFNKKYLDLVSKNGLVLSAHSDSGRRMEILEIPNHRFYFAVQYHAEFNSRPGKPEQAFDAFVKSAALAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFS0</accession>
    <name>K0IFS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60216">
        <property type="protein sequence ID" value="AFU60216"/>
        <property type="gene ID" value="Ngar_c33010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33010"/>
    <dbReference type="HOGENOM" id="CLU_2695899_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3301-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8501" checksum="2C2E6004A2487C7B" modified="2012-11-28" version="1">MSLRIPHRQDDAHAYARHPSYTLHYGFQEIKKQRLLQAKGLQVTGGYNIQPINNLLCRTITKVYTQSWGDDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFT1</accession>
    <name>K0IFT1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60246">
        <property type="protein sequence ID" value="AFU60246"/>
        <property type="gene ID" value="Ngar_c33310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33310"/>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3331-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13671" checksum="3F7F9832096F09A3" modified="2012-11-28" version="1">MSGSPSSYRDRIYIIKDVILKLVEYGELNQTALISFCGLNLKKHKAILDDLEENEMIERREQIVGKRTVTFYRPTQKGMAFCRDILEPYEKVFPRRKVEKKKSTTTTAKDLMLLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFV9</accession>
    <name>K0IFV9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c33660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33660"/>
    <dbReference type="EnsemblBacteria" id="AFU60281">
        <property type="protein sequence ID" value="AFU60281"/>
        <property type="gene ID" value="Ngar_c33660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33660"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3356"/>
    <dbReference type="HOGENOM" id="CLU_081974_2_2_2"/>
    <dbReference type="OMA" id="FHHPGIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3366-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12772" checksum="59728AF935BA1662" modified="2012-11-28" version="1">MSLGEMKCEPCRGGMPPLTDEEIEQYHRQTRSWSVIEKDGIKRLEKSFKFKDFAQALAFTNKVGELAEKEGHHPDILTEWGRVTVTWWTHKIKGLHRNDFIMAAKTDALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFX1</accession>
    <name>K0IFX1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Biotin synthase</fullName>
            <ecNumber evidence="3 12">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">bioB</name>
        <name evidence="15" type="ordered locus">Ngar_c17570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17570"/>
    <dbReference type="EnsemblBacteria" id="AFU58690">
        <property type="protein sequence ID" value="AFU58690"/>
        <property type="gene ID" value="Ngar_c17570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1732"/>
    <dbReference type="HOGENOM" id="CLU_033172_2_1_2"/>
    <dbReference type="OMA" id="ADRFCMG"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 12 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="52"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFU58690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="324" mass="35261" checksum="F0D8E6ECE8504CD8" modified="2012-11-28" version="1">MMADSAFIRSCTNKVLAGGSITFEEAERLLATDDVMTLAGCANTITRTFNGDTVDVEALINAKSGRCPEDCSFCAQSSFYDTGITKYPLLPKEVLVENARKAKEAGATSFCLVCAYREPPEKDFQQICETIAEIRSKVDIEVNVSLGFMTPARARRLRELGVKRYNHNLEAAESYFSKICKTHDFADRVNTAKIVKEAGLELCSGGIIGMGESKKERLDLAFSLASLRPDEVPINILIGREGTPMAGFEPIDPLEAIKTIAVWRFIMPKTILKIAGGREVHLKDKDRLALKAGANGIITGGYLTTGGNAPNKDIAMIKEIGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG07</accession>
    <name>K0IG07_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60341">
        <property type="protein sequence ID" value="AFU60341"/>
        <property type="gene ID" value="Ngar_c34260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3422"/>
    <dbReference type="HOGENOM" id="CLU_1291992_0_0_2"/>
    <dbReference type="OMA" id="FFIAFSH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3427-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="22928" checksum="8A5323F0352141B8" modified="2012-11-28" version="1">MVEILFFELPMNLLGLGISAFIGRFAYSGYAAVASPNLLRLTFAFVSIAIGFAILAAGLLAGEYSRAVTTAGLAAQALGYFFIAFSHSLKSFDFAPPRHFLLVPLAVTGFVIPGNSIEHLVRSISFILLVYVSIETMASYMQSRRTNTLMIGSGLGLLAAAELLSWYNFIYPGSFYIAALSIKVAGFALMFIPFSKFGMASGLGRMNSQIGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG49</accession>
    <name>K0IG49_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57788">
        <property type="protein sequence ID" value="AFU57788"/>
        <property type="gene ID" value="Ngar_c08460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08460"/>
    <dbReference type="HOGENOM" id="CLU_122701_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-844-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="190" mass="20368" checksum="4FBC0143440B0BFA" modified="2012-11-28" version="1">MFFGIKIAIVFLCFKVLISLYIKSCLLTADKSLIGKIMVAGVIIAVVAITAVIVFSMQQGSGGANVAAAPNVKFVSFDADRKGIKVGEATNMFYNVQNFEERAIEDARVTIMIEPSGFEPYLSISNQTVDLPQLLGKDAATGEIKVSITAKSTPAKEAVYVVKGVLLVEGIQTDTKQFELKISQPTGIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG69</accession>
    <name>K0IG69_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative surface-associated Ca2+-binding protein, cadherin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08710"/>
    <dbReference type="EnsemblBacteria" id="AFU57813">
        <property type="protein sequence ID" value="AFU57813"/>
        <property type="gene ID" value="Ngar_c08710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08710"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.829"/>
    <dbReference type="HOGENOM" id="CLU_365478_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-869-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="763" mass="79975" checksum="6CCAE86D288BCC2F" modified="2012-11-28" version="1">MVLLSFIPAILSLQQAFADEYLLTDQESCKLEPLSGNWDEVSTTCFVEGFTLEFGDILDISSGITLQNNGMISNNGGIIDNHGILSNADKIDNEGTINNHDTINNEGTIDNDNGIIENTGSINNLETIRNDGTINNLFGGVINNDDTLDNFSTIINLFGGTINNSYMINNHGVVDNSGNFDNGGTINNHGTINNAEIFNNPGMIDNFCTGIINGPINGNQPIDLCGQPIVANSQTIVINEDTQVHITLTGSSHNEDDILTFAIVDLPSNGSLAGGAPHFVYTPNSNFFGTDSFTFTASNGTVNSNPATVMILVIAIDDPPTAVDDAVMINEDETITIDVIANDGDIDMNDDTAVISVSDSENGVTIIAGYKTITYTPNANFYGSDSFRYVVSDVSGSTAEATVWININPINDPPVANDQNVVTNEDMMTSISLSATDAEQDDLSYLITSQPSHGTLTGSAPNLQYIPAANYFGPDSFTFEVSDSDLTDSATVSITVNPVNDNPEALDDVATTSQGIAVTIDVLDNDGDIDDPEDSLSVESVTTPANGVAVVNSDNTITYTPTGTFVGTDSFTYTISDGNGGTATATVIITVKNPLPPVEEFCGVPIDSFDNVIDGTSGNDKLFGTNGDDLIRGFGGNDIIVGGNGDDCIIGGDGNDKLWGGNGDDMIEGGSGNDLISGGNGDDVINGGDGNDTIYGKNGDDTLAGGSGNDQISDSNGNDNTDGGAGTDNCYDKEGRNTVVNCEGNKTIKEKNDKPPEPTKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGA8</accession>
    <name>K0IGA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60441">
        <property type="protein sequence ID" value="AFU60441"/>
        <property type="gene ID" value="Ngar_c35280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35280"/>
    <dbReference type="HOGENOM" id="CLU_2299436_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3529-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="102" mass="10923" checksum="CBACA73000437729" modified="2012-11-28" version="1">MSSGDASSSPAPAAAIPFPTLTILYLPSEAKAVIDEVGQKYPNSTVEDCVGFFHGSQKHYKKVTIWSQGIDSLWLNAVVARTKELAGVEFVTLVSGGMMYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGH8</accession>
    <name>K0IGH8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57938">
        <property type="protein sequence ID" value="AFU57938"/>
        <property type="gene ID" value="Ngar_c09960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09960"/>
    <dbReference type="HOGENOM" id="CLU_2968567_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-994-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6819" checksum="154B0178659DBFC6" modified="2012-11-28" version="1">MITVSLVAYKKYLQWSLVMQRQFPSNRMMPGLVQHLEDVLKIVDETAYNYNLDLSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH54</accession>
    <name>K0IH54_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58163">
        <property type="protein sequence ID" value="AFU58163"/>
        <property type="gene ID" value="Ngar_c12230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12230"/>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OMA" id="MIYEDRT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1221-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="15985" checksum="0022D849209A9329" modified="2012-11-28" version="1">MKFTKILVCVDGSESSAKAADYAIEIAKNHGAQMIALNVVVSQLGYAYSSGAFGLVTPSTINDLLAKAKQEARKWFDEIERKAAEQGVKVKTEIVASPTSVVPAIVDYAEKNKVDLIVTGTKGRSGFTKLLLGSVASGVVTYATCPVMVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH73</accession>
    <name>K0IH73_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpl32e</name>
        <name evidence="6" type="ordered locus">Ngar_c23140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23140"/>
    <dbReference type="EnsemblBacteria" id="AFU59240">
        <property type="protein sequence ID" value="AFU59240"/>
        <property type="gene ID" value="Ngar_c23140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23140"/>
    <dbReference type="HOGENOM" id="CLU_071479_3_1_2"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00810">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023654">
        <property type="entry name" value="Ribosomal_L32e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_L32e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="16087" checksum="5E74963D6D9291E0" modified="2012-11-28" version="1">MVINEELLAARKKVAEKRPKFIRQESWRYDRLAENWRKPKGKDNKMRKQKSGMPAIVKVGYRGPRAARGLHPSGYTDNVVHNVAELARLDPKKDAARLGHTVGKRKRTEIIAKANELGIKVLNAGLLAPKKEQEKEKENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF1</accession>
    <name>K0IHF1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02590"/>
    <dbReference type="EnsemblBacteria" id="AFU57207">
        <property type="protein sequence ID" value="AFU57207"/>
        <property type="gene ID" value="Ngar_c02590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02590"/>
    <dbReference type="HOGENOM" id="CLU_2476116_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-259-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9474" checksum="D59D9279A282F097" modified="2012-11-28" version="1">MAAILGSSQPALAQTTYAMSSSAANENDDIPSDVQDNNSSSEAQQLPGEEGFSMRLLAMNLSAPHNILYGPDSVLWIRVRRKEHYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHG7</accession>
    <name>K0IHG7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tpiA</name>
        <name evidence="4" type="ordered locus">Ngar_c02940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02940"/>
    <dbReference type="EnsemblBacteria" id="AFU57242">
        <property type="protein sequence ID" value="AFU57242"/>
        <property type="gene ID" value="Ngar_c02940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.287"/>
    <dbReference type="HOGENOM" id="CLU_104921_0_0_2"/>
    <dbReference type="OMA" id="IPVYAQH"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="219" mass="23410" checksum="B3B547369C82AD29" modified="2012-11-28" version="1">MKRPLIINFKNYAEVSGDKAIKLAKAAQAVAKKLKVEIVVAPPQPALAVIAKSVRMPVISQHVDDEKVGSSTGYFLPEIAKSYGAVGSLINHSEHRMEMKNIANLVERLRSLRMTSIVCAREPWEVMEISLFQPDFIAIEPPELIGTGRAVSKENPAIITKSIEAAASRSKVICGAGISGKDDVAKAMELGSHGILVASGIIKASSWPAKIAELAAGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ2</accession>
    <name>K0IHQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wecB</name>
        <name evidence="2" type="ordered locus">Ngar_c15390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.14" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15390"/>
    <dbReference type="EnsemblBacteria" id="AFU58473">
        <property type="protein sequence ID" value="AFU58473"/>
        <property type="gene ID" value="Ngar_c15390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15390"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1503"/>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_2"/>
    <dbReference type="OMA" id="QAVAHNE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="1">
        <location>
            <begin position="198"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="482" mass="55069" checksum="40BCCBD44EB6AC48" modified="2012-11-28" version="1">MSVREIDVSRSLLPVKVSDNLQSVFAKARKEGTPVLAIVTGTKPDFYKQAPLVIEAAKENLPVFVINTGQHFDEVLGFGIEEFNLQQFVGCNLQIRGDLMEKASELIIKFGSFGRYCRKNFGTESLLPIVHGDTLVAGIAPLAWVFGMGQKVGQNEAGLRSMSPEAIKRLKACREPTKAEIRRFISSQFDGRWFLAREEPFPEQIDTWICSAGTQFFFAPTKLNRDNLVREGYPENFVHVVGNSVVDAIHQKRKEKSRQSIFDLYPQLEKGQWIRMDIHRRENLTHRRFTSIIGGLVQLIKNTDKKVVLVMLNATVSALKQYNLESKLKGLTEEHPDKFIMTPLWKEYANVIEFLDSGRCWAEMTDSGSMQEELLYFPKVTSLTVRLNTDRPETIFDAKSNILVPPLSPNWIASIVNEAYDKEEGLGMRLRRKKQMYGRPGQVSRSIIKIIKKEFENGDANFYPWLHQRLGLWKEGQGLDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ5</accession>
    <name>K0IHQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemolysin-type calcium-binding region signature-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58478">
        <property type="protein sequence ID" value="AFU58478"/>
        <property type="gene ID" value="Ngar_c15440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15440"/>
    <dbReference type="HOGENOM" id="CLU_1551871_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1542-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="172" mass="18756" checksum="CD0FFE6A6F3BA945" modified="2012-11-28" version="1">MPKNMIAVAEIQSDKREKIVCNLSLRFNCIFWWQTRYCVNIQSVTAFPNDLTLDKKQSIMGLNNYLPTLAPLALAALLVLPLMAAFAATISGTPDNNVIKGTPYRDTIYGYGSSDKLYGGIGDDDLYGGSGNDYMHDMSGYDTDNLYGGSGADIIKCKGYQCNVHGDSGNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ8</accession>
    <name>K0IHQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25480"/>
    <dbReference type="EnsemblBacteria" id="AFU59470">
        <property type="protein sequence ID" value="AFU59470"/>
        <property type="gene ID" value="Ngar_c25480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2525"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_2"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2547-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="395" mass="44345" checksum="9C4D90E95C09BDB2" modified="2012-11-28" version="1">MKVSDRTHGVEYAIRDITAYARKYKASGKEIIYLNIGDPVKFDFKTPEHIKKALVDAVTRDENYYTDSEGLPELRQAIVEKESEKGLDVTEDDVIVTNGVSEGLDMTMASIVDPNSEVLMPGPYYPPYSSYAKFYGGKPVEFKLYEDGRPDLEDLRSKITPRSRALCIISPNNPTGEVFDRKSLQQLVDIATEHDLYVICDEIYDKIVFDSQFTGIGKVAKDAPVILLNGFSKAYLMTGWRCGYIAMNSSSKKLAGLREDIPKLARVRIAANLPVQIAAVQALRGPQAHIPKMVEKLRSRRDYVVKRLNAMGMQCRVPRGAFYVFPKINLGHCWKDDQHFVIDLLNNTGVLTVHGSGFGSAYGAGHFRIVYLPPEEMLEKAMDKLERFVNSKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU9</accession>
    <name>K0IHU9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ordered locus">Ngar_c15900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15900"/>
    <dbReference type="EnsemblBacteria" id="AFU58523">
        <property type="protein sequence ID" value="AFU58523"/>
        <property type="gene ID" value="Ngar_c15900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1558"/>
    <dbReference type="HOGENOM" id="CLU_022389_3_3_2"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="478" mass="51989" checksum="CB6595743E2678B3" modified="2012-11-28" version="1">MVHENCGVVGIFSLDGHNVIPFVIDSLRALQHRGQEAWGIAVPGKSPFRRLGLISSAAAEFPTVVKKYKSHAAIGHVRYSTLGKSTLENAQPLKVKDLCVAHNGTIANVEELSGMVGGCTFTPQTMSDTLVAAQRLVMHLADKEDMAEAMHILKGEMVGSFCFTFLTDGGSVYAARDPRGFRPLVLGHHRETNTYMVASESCALAAVGAQLVRDVEPGELVKMSKGGISSQQFANEKPHAHCAFEYTYFAHPSSIMEGINIYAARKRIGQFLARKFPITNADVVVPVPDSARPAALGYAQELGLPFEEGLLKDRYSRKGSMRSFIEPYQSDRVEINKGIIPIQEVVEGKHVIVVDDSIVRGTSSAEIIKTLRMVGASRVSLVVTYPPIRYPCYAGIDFPSQEELVAYQHGVTEDSNATIGARVSQVIGADHIAYNDTSNLAKAIGMPEEELCFTCSTGNYAPLGIRPVFKSRIQMKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB3</accession>
    <name>K0IIB3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59670">
        <property type="protein sequence ID" value="AFU59670"/>
        <property type="gene ID" value="Ngar_c27490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27490"/>
    <dbReference type="HOGENOM" id="CLU_2662487_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2749-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8354" checksum="9E7FCD1906B96BDC" modified="2012-11-28" version="1">MSSSELAPDEEVLSLRYQGYNHDEINRKNGFSTGKISGIFAKEKVRFGAANVDAITRVGIQYAKAENHGPIWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIH9</accession>
    <name>K0IIH9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS4 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">Ngar_c09300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57872">
        <property type="protein sequence ID" value="AFU57872"/>
        <property type="gene ID" value="Ngar_c09300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.887"/>
    <dbReference type="HOGENOM" id="CLU_2766231_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-928-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="69" mass="7670" checksum="0ED9B612262AE9C5" modified="2012-11-28" version="1">MKVLPICVSTTTTYIHFLVAAQKVFTCTEAARCHPGDEPSSSPSHDAFTRLLRRQPPDPEALWKKRAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ2</accession>
    <name>K0IIJ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58873">
        <property type="protein sequence ID" value="AFU58873"/>
        <property type="gene ID" value="Ngar_c19410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19410"/>
    <dbReference type="HOGENOM" id="CLU_2230465_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1939-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12496" checksum="1D3F48DBCE4F0594" modified="2012-11-28" version="1">MKSYSQIPKTYEKELFSKGSTDQVLQDNPKLVTRLAWQFYRYSFIDSHKAMLEQLEEVRNEISTYPWLTGEHSKQELVPLFAMFNSYMNKADFYTQTSHNITNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ3</accession>
    <name>K0IIJ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59720">
        <property type="protein sequence ID" value="AFU59720"/>
        <property type="gene ID" value="Ngar_c27990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27990"/>
    <dbReference type="HOGENOM" id="CLU_3039183_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2799-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6036" checksum="C7F34BC7836986AC" modified="2012-11-28" version="1">MAIIRPLALIAGIADKAYVLRAIISFIPVMMFYDSSILCLVLFANLTFSVLRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ8</accession>
    <name>K0IIJ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c09600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57902">
        <property type="protein sequence ID" value="AFU57902"/>
        <property type="gene ID" value="Ngar_c09600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09600"/>
    <dbReference type="HOGENOM" id="CLU_471465_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-958-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027560">
        <property type="entry name" value="PEFG-CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04296">
        <property type="entry name" value="PEFG-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="578" mass="59045" checksum="2BAA24242DBE7CAF" modified="2012-11-28" version="1">MQYPKLAKHKQLLGVIIAAVLLTVIFVPFQKANAFTVTTTLPNAVGGAINNSVSGENFQITINVEAGELISIQSITLILDNGLASVKTATFNSAGTRTGGSDTLVIGNQLTISSFTANGGYGYGYGLVSSGYSFTSPYTYAFNNYGYGYIGGNTGGYANAGVTNFVNGLIGPGQITITGKLRTADLDTATPHTLDVLIDTGAGGNNNDQLVAPQLGFNVNANNNLVSVSVNVSANTPVGVTVPSTGDKVSISFGGSASGAVVVEKKTLSAINSQFPGAFTSVGSSTASFNVGSSTANTIGEVFEFDLSATSYSGSVRVTVPYNSALLSSGQSPSIFKWTGSAWEQGTNVSSNSTHVTGTFTSLSPVVAGALTPASSGGGSSSGGGGGGRGPVIISPDGTTPTTEPIPQEGDGSGGGGTGAVQWQTFSLDVEGTSYNIQYNITNGSVEDMMLDIDNRRLVVSVTSTNEDGNLKLRLPREVIDSKSGADGKSGTDQPFTVFLGDGTAATSEEGTPTATIRQISINFPAGTEEIQILGTFAVPEFGGIAAIILALSIVGIIIATARYATRNNRFSSFRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIV0</accession>
    <name>K0IIV0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59895">
        <property type="protein sequence ID" value="AFU59895"/>
        <property type="gene ID" value="Ngar_c29770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29770"/>
    <dbReference type="HOGENOM" id="CLU_3057263_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2977-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5778" checksum="90E94D583D547E64" modified="2012-11-28" version="1">MTQLKDLVDGTVVGSGSDFIVIQKGKKRLLLESPNFTIKELKSATTPYGSHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIY5</accession>
    <name>K0IIY5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaJ2</name>
        <name evidence="8" type="ordered locus">Ngar_c30340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30340"/>
    <dbReference type="EnsemblBacteria" id="AFU59950">
        <property type="protein sequence ID" value="AFU59950"/>
        <property type="gene ID" value="Ngar_c30340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30340"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3004"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_2"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="370" mass="41561" checksum="13C6DAE293B8A7DB" modified="2012-11-28" version="1">MSSKRDYYEVLGVQKGASKEEIKNAYRKLALQYHPDRNKDKAAEEKFKEISEAYAVLSDDEKRKRYDTYGHVGQEEVFRGSEANFDEIFRDMGFGGFRDIFEQFFGGARRGGFFGEDLFGFGGRRKGRDIIYDMELTLEDVLRGRKEEVDVPRMGRCGECGGTGAAPGTKPRKCTVCDGQGQTRRVYSQNRFSTFVTMEPCRTCQGRGQIVERPCGNCQGAGMARQVKKIKLEIPPGVEDGMAFQMRGEGEISDSGIPGDLVVRLHVQPDPRFERLEDGHLLYNLDVKFTDLALGTELKVPTIEGHEKLKIPQGTAANAILKVKGKGLPRYGRSGRGDQLVKINVKVPTKLNDRLKSLLKELDRELDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD6</accession>
    <name>K0IJD6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative methylated-DNA--protein-cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c23120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23120"/>
    <dbReference type="EnsemblBacteria" id="AFU59238">
        <property type="protein sequence ID" value="AFU59238"/>
        <property type="gene ID" value="Ngar_c23120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2287"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_2"/>
    <dbReference type="OMA" id="TFNEQCY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2310-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="7">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="117" mass="13049" checksum="D7511F91F03CB7C8" modified="2012-11-28" version="1">MKYLYLIFYHMKRQLKASDVYDILVRIPEGKVTTYGDIAKALGHPRASRAVGRILNSNPNPIIVPCHRVVMSNGSIGGYAFGKARKKGLLKKEGLRFMGDNMLHDFAGCRANLVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJE7</accession>
    <name>K0IJE7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59263">
        <property type="protein sequence ID" value="AFU59263"/>
        <property type="gene ID" value="Ngar_c23370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23370"/>
    <dbReference type="HOGENOM" id="CLU_796008_0_0_2"/>
    <dbReference type="OMA" id="HEDASIW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2335-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="348" mass="37804" checksum="4E0EA4F6BCCF552D" modified="2012-11-28" version="1">MMANMRILAIAVCALVLVVLAFPPLFTSVYAFDSPEMILKSSFVDSEGRVNVVGTVRNFASTPVQVTVGVETDDGSTLQKQTYGKVIWPLTDSPFKFVLDDGVVNAGEPFIMDVQEAKVSNYDSMLILSYNGMAVGEEKAFVGTVKNIAPFEMYNVSVFAAVHSPDHMSQLDTVRSNIIPVIKPGEQVEFTALPDPAIRSDVLYYSCAGLDYDNPITTIKTGDGGFVAYNLNAVAQVNNLRYENLTDSIAFGVRPYPPNGTTVNLQLPQYSQNQTITVMLDGELHEDASIWGDGKTLYIDFFVPQGDHQVKIQGVRNVPEFPFAMLALAAVTAGAIAAAKFKAAFKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF2</accession>
    <name>K0IJF2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">egsA</name>
        <name evidence="15" type="ordered locus">Ngar_c23480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23480"/>
    <dbReference type="EnsemblBacteria" id="AFU59273">
        <property type="protein sequence ID" value="AFU59273"/>
        <property type="gene ID" value="Ngar_c23480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2322"/>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_2"/>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NADP+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFU59273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="354" mass="37664" checksum="5F4794055474B9D6" modified="2012-11-28" version="1">MNSPPTHLMELPRKILIGGGVVSEVGSLVRSLDASATEVAIITGAVVKARAGRECDSSLEKALLKSSWYVVSDASMDTVTRLQNKIADKELDFVIGFGGGRSVDVAKMTAFKIGKPFLSVPTSASHDGISSPFVSVRGTDKPHSVKANTPIGVVADTRLMSRAPPRLLAGGCGDLVAKITAVKDWELGRDEKGEYFGSYAANLAYMSAKIILDESEKLKHKSQFSIRTIVEALISAGVAACIAGSSRPCSGAEHLFSHAVEYVAGPSYGLHGERVGLGTIMMAKLHGLDWEKIAATLEKVGAPTKAKQIGLTDEHVVKALTSAQSLRPDRYTILSKIKLDEKSAHRLAKSTRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG2</accession>
    <name>K0IJG2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60165">
        <property type="protein sequence ID" value="AFU60165"/>
        <property type="gene ID" value="Ngar_c32490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3243"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="OMA" id="EKWVLHI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3249-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14414" checksum="3BFDD50BBA3C22E7" modified="2012-11-28" version="1">MIEGLTDGKGATCAIVGVWEVLGRRWSLHILKNLSTKEVIRFNELKRSLAGISSTVLSERLLELEREGLVTKKIYPEVPPRVEYSMTPQAKELEVIIKELARWAEKWKRPAGLRVATAATVAAQKKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJL4</accession>
    <name>K0IJL4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60225">
        <property type="protein sequence ID" value="AFU60225"/>
        <property type="gene ID" value="Ngar_c33100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33100"/>
    <dbReference type="HOGENOM" id="CLU_3039186_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3310-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6077" checksum="B5F6285033E0B4E4" modified="2012-11-28" version="1">MTQALWESRQQVAACACSVCNHQNTRTCIEERCNCCSVEHAFLLTNPAYEEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ2</accession>
    <name>K0IJQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33800"/>
    <dbReference type="EnsemblBacteria" id="AFU60295">
        <property type="protein sequence ID" value="AFU60295"/>
        <property type="gene ID" value="Ngar_c33800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33800"/>
    <dbReference type="HOGENOM" id="CLU_030805_0_5_2"/>
    <dbReference type="OMA" id="IGNVIVM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3381-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="272" mass="29514" checksum="3C3E8C1E2D355F7B" modified="2012-11-28" version="1">MTMIAVEILCIGNELLSGITLNSNAHWLAGQIAGAGGIVKRVTVVRDDLGEISAAVQESLARKPDILITTGGLGATYDDLTLEGVALALGRKTVLDNRAVEMLKKSYAVRKLDYELTEARLKMAKIPEGSTPIQNLLGSAPGVFLQAGEKKTKIFCLQGVPSEMKAIFEKHVMPIVKQGVGRFVALEVNYNVRGVTEAMIAPTLTSIVGSHPKDAIYLKTHPQGYYRKKTPQIKIQLISRGNNKKEVKKRLDAIAVTIEKEVARLGGRILLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK86</accession>
    <name>K0IK86_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c17740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17740"/>
    <dbReference type="EnsemblBacteria" id="AFU58707">
        <property type="protein sequence ID" value="AFU58707"/>
        <property type="gene ID" value="Ngar_c17740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17740"/>
    <dbReference type="HOGENOM" id="CLU_2534505_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1772-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9146" checksum="AA45D327384B1C18" modified="2012-11-28" version="1">MHTAPANEAVNTIIKRCSDLFGSVATENAAIRLIKSENNNNSVTIIKCRLNQLENVLVAIALSDPPVVTLDMSGSIKQLKRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKA0</accession>
    <name>K0IKA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58747">
        <property type="protein sequence ID" value="AFU58747"/>
        <property type="gene ID" value="Ngar_c18140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18140"/>
    <dbReference type="HOGENOM" id="CLU_904941_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1812-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="307" mass="34065" checksum="1E4AD66FC30FF1A9" modified="2012-11-28" version="1">MGNVLTACLDLLKIDDPEVRKKAVEFVGSVPLGTVNTYGKWITAAKAIADSCAVSGRLFSQSEMCDFLTVAAKGVDSKRAGAKAVNDATFHIYVDIMENYQKSDDRVKLHYPRIIVDTISALDKGVDTRGEAVGVYSLDRYYQERKSTAILEDPAATYVGTPTSEKPASSASQDLPSYSDELVENLVHITGRPRKDLEQSLAGLQAADIKKITDLSLNYKRLQKYSKLLSSPAAFKKEVEKELGRKLTDNQLQHAINSIRKAKTYIENVLDGKFVPHGTHGINHVKHNLEYGYQLMGLMEPRKRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKB4</accession>
    <name>K0IKB4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">Ngar_c27470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27470"/>
    <dbReference type="EnsemblBacteria" id="AFU59668">
        <property type="protein sequence ID" value="AFU59668"/>
        <property type="gene ID" value="Ngar_c27470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2723"/>
    <dbReference type="HOGENOM" id="CLU_031942_3_2_2"/>
    <dbReference type="OMA" id="RMLNYSA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="263" mass="29047" checksum="411396434D0B37B2" modified="2012-11-28" version="1">MAAGMTIREHIEELRTRVFRVALSIIIITVFAMTFDLRPVEVAGLPLAYPYPDPIHNISTRLTFYMQDTLLPEGVGLIQTAPGQAFFAQIYVSALIGLIASIPIIVREISAFISPAISTKTKIGVLNIFLPAVALFVTGLVFSYFVVIPFTLNFLYQYGEALNVATFLTINDFISFVMQFFLGFGVAFQLPIVMYGISMTDAVSPRFWRDNFRYAALILVIFGAIITPDGSGVTMWFVAGPMLVLYAAGMLVVERRAAVKTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKU9</accession>
    <name>K0IKU9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aldolase LsrF</fullName>
            <ecNumber evidence="3">4.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lsrF</name>
        <name evidence="3" type="ordered locus">Ngar_c22370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22370"/>
    <dbReference type="EnsemblBacteria" id="AFU59167">
        <property type="protein sequence ID" value="AFU59167"/>
        <property type="gene ID" value="Ngar_c22370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22370"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2216"/>
    <dbReference type="HOGENOM" id="CLU_057069_2_0_2"/>
    <dbReference type="OMA" id="MFNERTF"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="28301" checksum="4BA6667D7F3ECD10" modified="2012-11-28" version="1">MLAVDHGYFLGPTERLEVPRKTIEPLLPYADSLMLTRGVLRTSVDPTTDVPIVLRVSGGTSIIGEDLSKETITVSIEEAIRLNVVCLALSIFVGSKYEHQTLTNLAKLVDEGEKYGIPVLAVTAVGKEMGRDARYLGLACRVAAEQGAHVVKTYYCENFEQVVEGCPVPLIIAGGKKLPEPDALKLAHDSITHGAVGVDMGRNIWQSDYPVAMIKAVRAIVHKNVDAKEAYGIFLKEKEKEPIQKETKVLKAVSQSGSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKY6</accession>
    <name>K0IKY6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59212">
        <property type="protein sequence ID" value="AFU59212"/>
        <property type="gene ID" value="Ngar_c22840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22840"/>
    <dbReference type="HOGENOM" id="CLU_1357952_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2282-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="201" mass="22242" checksum="7434030DEFC525F1" modified="2012-11-28" version="1">MNQYELAILRILLKSTVPLSKSKIVEGSPDDSSDFALSAISDLKRANFIVATNEGFSNEMLELAKDRKRDVIMFLNPSQNDLPADRSESKGKRMMWITATLMIMGAFASVYMAYAAGVNDRVASSQLQPASYRDVKFGVVRWLPEGYAADIAERPTATLHLKPLNEYSAKIEALPKDISVKYYLAPEFTEGTPAAQPKTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL20</accession>
    <name>K0IL20_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59267">
        <property type="protein sequence ID" value="AFU59267"/>
        <property type="gene ID" value="Ngar_c23410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23410"/>
    <dbReference type="HOGENOM" id="CLU_2340013_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2339-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="11754" checksum="2875E46E93FBB67F" modified="2012-11-28" version="1">MAKRQFTIDTGKEQIPVEGQVHRNVAVKYLMKRRRSLLMTKNPEKVEKLWTELPKKIKIIGKQLTREYKVNWERVGTQDYEGSRFVFTLDDLGEKTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL26</accession>
    <name>K0IL26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60118">
        <property type="protein sequence ID" value="AFU60118"/>
        <property type="gene ID" value="Ngar_c32020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32020"/>
    <dbReference type="HOGENOM" id="CLU_2581539_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3202-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9285" checksum="F7F69FD704FECBB2" modified="2012-11-28" version="1">MGLFRRWKPKGKMYSLKCTQCGSGFLSSYNLEAPICGKCLQKAKSLDSTIDHEKACIKCGTQGVIYGKEYCYSCYFGFQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILD2</accession>
    <name>K0ILD2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34180"/>
    <dbReference type="EnsemblBacteria" id="AFU60333">
        <property type="protein sequence ID" value="AFU60333"/>
        <property type="gene ID" value="Ngar_c34180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34180"/>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="OMA" id="FFRYGAK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3419-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="223"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="565" mass="63196" checksum="7B9AFB675CE50636" modified="2012-11-28" version="1">MSSGYKIVLSGSKTAVSDFRHSNWIGFLGCIPSNYPKMPYSREIMENIFFPTQSDDEGRLKFAPYSLRKIEAALLEYGFTKDEVIIADPRKLDRAIGPETKAIGLTVHDPLGYSAVSQLNACLFRLINWWPAPSYTAAAFGDIIKNPLLKRYNSKLIIGGPGIWQLEEHPEMFKEWGIDCLVSGEAESIAGPLFESAVKGEAVLPERAASGKPLRSDKVPIIRGPSTGGVVEITRGCGRGCQFCTPDLLFFGSIPKENILKEVEIEVRHGIRRIELHSEDALFYGRKLGSFEVNHEAIVDLFTSVKKFPGVRQVATDFFACSTIKSAPKTVKAMSEIMELDKKHPGYVETGLETVSPRLVQNIMPGKVKPYTIEEWPDVIDDALGILDDNHWFTVASMMTGLPKETEQDVIRSIEFIDRIKHHNVFVWVFPLMPLRAMLKNAAKWAPEYTPLRQELILKATRHSISLINREAPRILKVLPVWARPPALLALKYVTGMTLHFFKGADEAIARHEDRLNLYKDLQYAHNKEGEAVMHVSSVVNELVKIGGGSTTLLPEEEQNLLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW6</accession>
    <name>K0ILW6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps11p</name>
        <name evidence="4" type="synonym">rps11</name>
        <name evidence="7" type="ordered locus">Ngar_c04580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04580"/>
    <dbReference type="EnsemblBacteria" id="AFU57404">
        <property type="protein sequence ID" value="AFU57404"/>
        <property type="gene ID" value="Ngar_c04580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.441"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_2"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="14419" checksum="4A1E63BC8EB8F445" modified="2012-11-28" version="1">MSETTDEITQTKWGVAHIFSSYNNTLVHITDLSGSETISFSSGGRHVTADRYESSPYAAMKSAVAAAEVAKAKGINALHIRVRAVGGVGPRIPGPGAQAAIRALARAGFRIGRIDDVTPIPHDTTRKPGGRRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM75</accession>
    <name>K0IM75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57624">
        <property type="protein sequence ID" value="AFU57624"/>
        <property type="gene ID" value="Ngar_c06810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06810"/>
    <dbReference type="HOGENOM" id="CLU_3021088_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-679-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6399" checksum="87545A8A953819FC" modified="2012-11-28" version="1">MPRINLTVNDDNYQFLKDMKDSGKAASLSHAVRLVIQEYRRLHEKPSTRKRRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC4</accession>
    <name>K0IMC4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57769">
        <property type="protein sequence ID" value="AFU57769"/>
        <property type="gene ID" value="Ngar_c08270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08270"/>
    <dbReference type="HOGENOM" id="CLU_2802393_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-825-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7443" checksum="53A36128064AC6D0" modified="2012-11-28" version="1">MSKRGNASHNIHSIIILSDKGSTHAIYEEILNYLSNDQAVIYAAEPNPSNKRDTENVKGEESARCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME2</accession>
    <name>K0IME2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase IS200-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57834">
        <property type="protein sequence ID" value="AFU57834"/>
        <property type="gene ID" value="Ngar_c08920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08920"/>
    <dbReference type="HOGENOM" id="CLU_101320_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-890-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5987" checksum="D1C8F4DAA7BA84AC" modified="2012-11-28" version="1">MKGYTSKILREEFPELKSRLPTLWTRSYFVSTHGHVSADVIKKYIEEQKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMF0</accession>
    <name>K0IMF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60212">
        <property type="protein sequence ID" value="AFU60212"/>
        <property type="gene ID" value="Ngar_c32970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32970"/>
    <dbReference type="HOGENOM" id="CLU_2379511_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3297-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="10848" checksum="C3BAB78CDFF18B15" modified="2012-11-28" version="1">MLQCRFLAKGLRENASCSCIAHDKSEADIIERELLDNGIDVFSYLNNNRLKIRYCQIIITIVACFNPSLYQRRTQKTKIIFIRSSYAPTICLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM5</accession>
    <name>K0IMM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c10820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58024">
        <property type="protein sequence ID" value="AFU58024"/>
        <property type="gene ID" value="Ngar_c10820"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10820"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="GMVKNHC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1080-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="273"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU58024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="378" mass="44667" checksum="62064FED35F453BC" modified="2012-11-28" version="1">MLNYKFRLYPTKEQELVLEQTLDGCRWVYNYFFDKNMSKEDMQFTLVELKEQHPWLRKYYHSKMLQMVTHQVAAARKASKDKLLSYRKNEDFNAFTYNQSGFKIEEDGKLYLSKIGSIRIVLHRKPVNVKQVTICRKNSKWYAVAACQLLRRMYSTLIKYRKPVGIDVGITKFCHDSDNHVEDNPQLLTKMLRPLRKAHRRVSRRQTGSSNREKARHMLARLYERIHNKRRDFLHKLSAYYASRYDLIFLEGLKVANLTRNHRLARKILDASWSAFKNMLQYKANRVVEVEPAYSSVDCSRCGHPVPKSLVVRTHVCTKCRAVLDREYNATINILQRGLESLIMLLLLLPVERREVTPVEIQHESVKQEEEEAIGQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP5</accession>
    <name>K0IMP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58079">
        <property type="protein sequence ID" value="AFU58079"/>
        <property type="gene ID" value="Ngar_c11380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11380"/>
    <dbReference type="HOGENOM" id="CLU_1850702_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1136-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15591" checksum="DDD0496783943DED" modified="2012-11-28" version="1">MDSRLKQMERKQKLYSLLKAQHDAEVKELMHYMSILTTVENNLVRSYLHTLLGDGLRHVEYISKIMANIEGATGSASLTKKGISESIKDEKESRDTLLQCAEMADDPETAALLKSISVDEEHHIRILEHLSELVGSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ2</accession>
    <name>K0IMQ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="3">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nuoC</name>
        <name evidence="3" type="ordered locus">Ngar_c11530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.5" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11530"/>
    <dbReference type="EnsemblBacteria" id="AFU58094">
        <property type="protein sequence ID" value="AFU58094"/>
        <property type="gene ID" value="Ngar_c11530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11530"/>
    <dbReference type="HOGENOM" id="CLU_042628_6_1_2"/>
    <dbReference type="OMA" id="EWHERES"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="91"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="215" mass="23782" checksum="013A88EEB5B79B83" modified="2012-11-28" version="1">MSANKDEPNKPAAASSPPPKPPAAKPPATATAAAAKQPAPAAAKPTAAGATPPKKEPEAPPFEKGLVEEIKKKFGESIIKVVFIKPFRIKIQVEPSNIVEVATFLRDNMGFDHAESVAGTDYPKDNQIEVIYHLGSYTREDLGAHILSLTTRTSRDDARLPTLINVYKSVEYHERETFEMLGVYFEGHPRNDRFLLPEDWADIPPLRKDFRIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR0</accession>
    <name>K0IMR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58114">
        <property type="protein sequence ID" value="AFU58114"/>
        <property type="gene ID" value="Ngar_c11740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11740"/>
    <dbReference type="HOGENOM" id="CLU_798368_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1172-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="347" mass="36921" checksum="1D8C241E6191A76F" modified="2012-11-28" version="1">MIITFVAVVSALVLLLSIALPTIGSSNSVSTQGPVNYYNDTSGANASSSATNDTTATTSSLNSTNNTAMPSESDWENLTTFELFELYPVLDNLTSGASNDTSAAANETGTGQQLPSQELNQQQNETQATATANTTLSDATQQNSIAAATMPPDLLNQLQTTISSINQSITELKRNMTNTTTISVDQVVVNEPVASSSTSSQDNDLGDSNQASPVFTFSKEITDDLKKDDYIILAHLAPYSTTKGHAEVELKVPCNNDEEPQVKLVAGSIPRLREVDLGKAIEIANVRGSDDEVKLSKAGEYCLYQAKLPAGITDVILVNDSGHKLKFSEDGRFYMAMTVGLDSTKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN68</accession>
    <name>K0IN68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58849">
        <property type="protein sequence ID" value="AFU58849"/>
        <property type="gene ID" value="Ngar_c19170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19170"/>
    <dbReference type="HOGENOM" id="CLU_2392987_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1915-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10702" checksum="2700A254F96EA531" modified="2012-11-28" version="1">MADSLGERFMELGYSNRERVLKKTYHGMLFSRYFGQSVGRLYGKMSDDLRSVVMCHVEKNAQFADRLGMGVGYVYATLEPTLQHEVMQKAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN71</accession>
    <name>K0IN71_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19320"/>
    <dbReference type="EnsemblBacteria" id="AFU58864">
        <property type="protein sequence ID" value="AFU58864"/>
        <property type="gene ID" value="Ngar_c19320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1911"/>
    <dbReference type="HOGENOM" id="CLU_007415_2_2_2"/>
    <dbReference type="OMA" id="CNFNPPE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1930-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="225"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="682" mass="74210" checksum="1D9B9237243D3E49" modified="2012-11-28" version="1">MTEYGVKVPKYALVKSADEAGRQAQAVGFPLVAKIVSPEILHKTDVKGVKVGLQNEAAVKETFNDMYGRLSKQYNSVKGVLLEKMAAPGGIELIVGLQNDPQFGPVIMAGIGGIYTEVFKDVSFRVLPITKEDAISMIEDLKGNKILKGFRGMPAVNMDMLATALVNIGKFGTEMAPYYESIDFNPVIFYENDYVVVDAKILLREKPDLEVISKAQPDSEYMDLFFNAKSIALIGASPEAGKVGNSVLESMVKHDYKGKVYPVNAKGYPEIMGIKAYKSLDEIPDKIDLVVVTVDLKFVPDLLKSAAKKGIHNFVIISGGGKELGGERAAIEAQIKELSRQLRIRIIGPNCIGMFNGENRLDCAFQGHARMIRPKQGNVAFLSQSGTVGIAFMESSDAFGMSKMISYGNRSDVDEADMIWYLSEDPQTKVVGLYVEGLGDGRKFMNTAKKVIKERGKPIVVFKNGRTARGAKQAASHTGSLGGSYGVVKGALDQAGIISVDNYEELTAALKALAWQPVPNGGRVAMVTNGAGPIINAIDHFERLGLSVAELTEQSRKALKDHYPPTYVIQSGNPADITGSANADDYRFAIQTFMDDPNVDIVMPWFVFQDDPLEETIVDVLASFQKQKKKPILIGAMGGPFTKKISQRIEDANVPVYHSVIEWVTAAGAMAKWARVSGKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN80</accession>
    <name>K0IN80_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative blue (Type 1) copper domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19770"/>
    <dbReference type="EnsemblBacteria" id="AFU58909">
        <property type="protein sequence ID" value="AFU58909"/>
        <property type="gene ID" value="Ngar_c19770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1957"/>
    <dbReference type="HOGENOM" id="CLU_613419_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1975-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="364"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="446" mass="46736" checksum="B0C995068FDB9A36" modified="2012-11-28" version="1">MSQPFPMNSTGILGSKLLLAVVASGALLTGTLFGITQTGVISPEIQQAAAQGTPAATPVNEPQKVDLDGVTVSFELTPKEVHAVDLVNMNIKITDTASGAPLSHVDWAIIVKDPSGREVYKTSTSHSHMGIESFSYAFMHPGKNTVQVQVASLGPKMMGMDVPKEAQTRVFKSGDPMKSPEVDQTFFFGTRSHDFVVNVGSPGGVKTISTDMGKKVELSLSTNPETVIAGQPTTLILDVKDATTGKHIMHPDALMTVRQGSFILTKSAPAGSPMMPMNGAYHGHTGQMALTVVFPTTGFYIIDIDTNSLPVSDVQYGHAGARFKVLVTEEDAGSAGSSKAASATTATTTAPNQVAILGQAAPYFGPQSLTVKAGTTVTFTNSDFVVHTATGTDAAPGNVAPAPNDTFDTGILGHGESKQIKFDKAGTYNYFCMIHPQMRGTVTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IND8</accession>
    <name>K0IND8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c22690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22690"/>
    <dbReference type="EnsemblBacteria" id="AFU59199">
        <property type="protein sequence ID" value="AFU59199"/>
        <property type="gene ID" value="Ngar_c22690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22690"/>
    <dbReference type="HOGENOM" id="CLU_043491_0_0_2"/>
    <dbReference type="OMA" id="EYNIYKC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2267-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="205"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="398" mass="46288" checksum="85D95C2128DCC62C" modified="2012-11-28" version="1">MARQVRGLAIVSIGSCIKRINKLHYKVKSQSSEETWYDVVRTYETGRGDSRQEGQWTCSCPDFLYRKIVCKHVYAVGFSKELRRRIVQQDVVQSPQLPIASQSVECPKCKLSDNIVKDGKRLNKSGAIQKYLCRSCNYRFIVNIGFEHSKKNPKIITVAIDLYFKGVSLRKVADHIKQFHNVKVDHTSILDWIHRFADEVAPFVDSMTPPHVSGICHVDEMMVHVRREKMEKGHYAWLWNLMDDTTRFWISSKISQRREVSDARAVFQDARIKTGEPKAIIHDGLPSYDKAYRQEYFRDRKHVKNIRSISVRNEGLNSRVERLNGTMRDREKVMRGMHSKESAQKIIEAMRIHYNYCREHSTLGKTPAERAGIKLNFETNRIESLIRYASNRGHESAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM5</accession>
    <name>K0INM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59634">
        <property type="protein sequence ID" value="AFU59634"/>
        <property type="gene ID" value="Ngar_c27130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27130"/>
    <dbReference type="HOGENOM" id="CLU_2461867_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2713-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10187" checksum="28DA7A67406C5D06" modified="2012-11-28" version="1">MQLVVHKGERFYKSFKPVAVLKKMLGVLFELVSKENIDRLTEQWAAESRNIVLLSGSSFFFGDCDCLYLQGIKIFHRRGRQAHKIQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0INN4</accession>
    <name>K0INN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS200 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27580"/>
    <dbReference type="EnsemblBacteria" id="AFU59679">
        <property type="protein sequence ID" value="AFU59679"/>
        <property type="gene ID" value="Ngar_c27580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27580"/>
    <dbReference type="HOGENOM" id="CLU_3263939_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2758-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="41" mass="4813" checksum="DA6441A1FAEF4A88" modified="2012-11-28" version="1">MKELLVERVKEIGCKLISLEIMPDHVHIFVEAHNLQQLQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INR9</accession>
    <name>K0INR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system-like protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c29360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29360"/>
    <dbReference type="EnsemblBacteria" id="AFU59854">
        <property type="protein sequence ID" value="AFU59854"/>
        <property type="gene ID" value="Ngar_c29360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29360"/>
    <dbReference type="HOGENOM" id="CLU_030780_0_0_2"/>
    <dbReference type="OMA" id="SAQILYM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2936-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="292"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="519" mass="56387" checksum="C5E142D11CC2367D" modified="2012-11-28" version="1">MSSIFKSLQQKDQKNKKNAKKPKPDKRLGERLDRELPYVITLITIMAASGITPFGSFSKLARYRLLPYIMREARNIIGQVHILGEDPLTAMEKRANVSASRQYRDLLMGYVSTVRNGGDIASFLQSKMKSIFEYEVAVARQSVAKIGGLVDAYMIMQVIGLSLYVVLVAMSSTSSGGGAALPVSLPSSPVFSYFIVFVMLPGISFAILYVMDKVVFTTLVGAKELLTKGIYFSLAAIVAFVALTATGVLQKAIDPAYALPIFLIAASAWPAYKAMKMEKNMKGMEADLPSYLRDVAESRKAGLSPEKCIVYASQRMRDSVFQSVVKSFANQLEWGVPLRKIYENLASSVKSFSALIHFRILIEAIESGGGYTTSLEILAQSSESSYNIDKEKTSMLKPYFFIAFMVTALTSITTLMVAQTFNEISGSVLALGATPATPAVEPQNSGELSSTQMLAIGIAAQSWMSGFLMGKISSGSFATGFKYAVMLLLISLLATVVTQEFNLSPSAFLSPPQTSQTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY4</accession>
    <name>K0INY4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">GTP cyclohydrolase III</fullName>
            <ecNumber evidence="1 2">3.5.4.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">gch3</name>
        <name evidence="4" type="ordered locus">Ngar_c32640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:22468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57258"/>
            <dbReference type="EC" id="3.5.4.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the archaeal-type GTP cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32640"/>
    <dbReference type="EnsemblBacteria" id="AFU60179">
        <property type="protein sequence ID" value="AFU60179"/>
        <property type="gene ID" value="Ngar_c32640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32640"/>
    <dbReference type="HOGENOM" id="CLU_080076_0_0_2"/>
    <dbReference type="OMA" id="VQIAHID"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043740">
        <property type="term" value="F:GTP cyclohydrolase IIa activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00608">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007839">
        <property type="entry name" value="GTP_CycHdrlase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42202">
        <property type="entry name" value="PTHR42202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05165">
        <property type="entry name" value="GCH_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009265">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="127"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="250" mass="28088" checksum="8B116A002153361B" modified="2012-11-28" version="1">MIQLTIIRIEGYGPWTVTLGSDREAQLQMLQAKIYHDVQRLFSEKNCIVFFNRFDEYFAITNGLDALDHKEIQRELAELYNDLKMSMAIGAGKTAFEANLNAYNARKEGRMLDNEARIFGNALDDADMAQIMHIDVDSSTKVGDRLSPYEITALVMKIYSRLAEEFLKRNALTFFLGGDNFMVISNGVTKEQTDAVIKKVTAGIDIKLNCGIGIGKTGRMAAEGATKALDTIRDLRKQGKIQPIYEIRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INY8</accession>
    <name>K0INY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60199">
        <property type="protein sequence ID" value="AFU60199"/>
        <property type="gene ID" value="Ngar_c32840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32840"/>
    <dbReference type="HOGENOM" id="CLU_1109528_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3284-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="250" mass="26077" checksum="0BF01F33F35ABA7F" modified="2012-11-28" version="1">MIHAKDLYRNRSRFIVPVLLGVVLAMPSTIAAVSAADLTGTNRSDMIYGTGEDDTIHGLGGRDIISAGAGNDKAYGGSGADKIYGYRGDDLLDGGEGNDYIQDSYGYNTVYGRGGADTINILFVEDTGDQFGSVGGTIHGGSGPDTISCEGYSCAIYGEGDNDKIYLQPHDVENVAYGGIDNDYIKGIGQAGALYGEDGDDTLVGGAEHHGGAGADRFVCDQYTEIFDYNPAEGDVIENESLCGGVTMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP26</accession>
    <name>K0IP26_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Leucine aminopeptidase</fullName>
            <shortName evidence="6">LAP</shortName>
            <ecNumber evidence="6">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pepA</name>
        <name evidence="8" type="ordered locus">Ngar_c34750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="6"/>
    <dbReference type="EC" id="3.4.11.10" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34750"/>
    <dbReference type="EnsemblBacteria" id="AFU60389">
        <property type="protein sequence ID" value="AFU60389"/>
        <property type="gene ID" value="Ngar_c34750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34750"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3476"/>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_2"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="7">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="501" mass="54220" checksum="9B61E79047E7A8C5" modified="2012-11-28" version="1">MVQVKVEKAKIDQKQTSLLVMGVFEGEQDFMQSKELDPTVFASIKETLENKEFRGTFGSSILVYTLGRGPMKKIMLLGLGKKDKFTDESARICAGKAAQKAKELGVKEFSILQFSNLDEGLIEAMTEGVTLALYSFDKYKEAKEPATKIEEVTILINSDSPKFQSIADKASLIIEAVNFARDIGNLPPNDCPPAQLASIALSLAQEHGMKAKVIDRYELENMGMGGIVAVGKGSNSPPKLIILEYNGSSDPQQKPYLLVGKAVTFDTGGISIKPGEKMDEMKFDKCGGCTVLAVMRAVASMKLAVNVVGIVPSVENMPSSTSYRPGDIIRMYNGKTVEVLNTDAEGRMILADALAYGIATYNPKAVFDVATLTGAAVIALGANVAAIVGTNKQLTDRLRKLADKTGERMWELPLYDEFHEQIKSTYADIKNVGGRPGGAITAAAFLSNFVNGVPWVHIDIAGTAWTQDGTYEKSYNPRGATGFGVRTLVKLLMEDEKQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I728</accession>
    <name>K0I728_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_OrfB_IS605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01210"/>
    <dbReference type="EnsemblBacteria" id="AFU57071">
        <property type="protein sequence ID" value="AFU57071"/>
        <property type="gene ID" value="Ngar_c01210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01210"/>
    <dbReference type="HOGENOM" id="CLU_3178701_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-121-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="6084" checksum="1974E7C9D912970F" modified="2012-11-28" version="1">MCNYKYRLYPTREQETKLEETLDGCMGVYNYFVSNGFSSEYDMNYTILSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0I766</accession>
    <name>K0I766_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L30e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl30e</name>
        <name evidence="3" type="ordered locus">Ngar_c01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01570"/>
    <dbReference type="EnsemblBacteria" id="AFU57106">
        <property type="protein sequence ID" value="AFU57106"/>
        <property type="gene ID" value="Ngar_c01570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.156"/>
    <dbReference type="HOGENOM" id="CLU_130502_1_0_2"/>
    <dbReference type="OMA" id="KEDRCTI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="2">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="11219" checksum="120E3531EA5ED486" modified="2012-11-28" version="1">MKVLEKVIRDAVAADKYKSGVKEVLQSVKGTKLIIVSKSIDSADRAKLEEQAKAANVAVYEYHGTSVQLGKLCNKPFRITAIAIKSGTAAEIEAIMAEKEAAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7K5</accession>
    <name>K0I7K5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02780"/>
    <dbReference type="EnsemblBacteria" id="AFU57226">
        <property type="protein sequence ID" value="AFU57226"/>
        <property type="gene ID" value="Ngar_c02780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02780"/>
    <dbReference type="HOGENOM" id="CLU_431255_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-278-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="611" mass="66677" checksum="281C207F83FFB80F" modified="2012-11-28" version="1">MKRYPASLVLLLLLLAAIVPFIPFPAYGHGLGTDKSLPATISDKQVSVEATINPSFIDQVAGTNPTFVIRALDDTKLDSTIPGVDFHIVVELRDEIVLDQHFRSSDGVVAANLIPDGEIDGWEINGNNSPSPTDRIKVSKSNPIELKSKILSAGGLYHIAVTIESSSPGIAVQSDRKFDLYVSVGRTYTYDVQGNNQMVVKTYYDDVNNFNYSNGTISFEMPFTWNEDYVSQVPVLHMEVQFPKTIEELRTNSYRGTLNGMELEAQAVVIDDYSSEQNRIVHFVVNNAMLTRFAERVEDTDVAAFSLKPAEKPKFPLDIMSLPGEKFLFQLSWGPDLIETGTPITFVMNIQDPATGEVIRGSSFDFVLTQNGREIHRQHLAEDFGTYAYDYTFSNPGTVTLSARNINGQRESASIDLVVLQGSSPTPQPPQQPSGCLIATAAFGSELTPQVQYLRNFRDHYILSTVSGSAFMNTFNSIYYSFSPQVADYEREQPWLQATVKAGLYPLFGILMVSERAYSAVEGEAGAILAGATASSLIGAVYLWPAGMAAKRVGYKPLAIIIGAATTVLAITLVALPALLPLSTAVFVVAAAGVSAIAVTKAIRYVRSQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0I889</accession>
    <name>K0I889_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57486">
        <property type="protein sequence ID" value="AFU57486"/>
        <property type="gene ID" value="Ngar_c05430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05430"/>
    <dbReference type="HOGENOM" id="CLU_1187815_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-541-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="78"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="24805" checksum="688321FF1CC74A8B" modified="2012-11-28" version="1">MGTAGLAWDVGDYISAARMNQKDELVGTGAEIAGISPTYPGQQAFCTATGSGFTVDTLYQRNAANTAWNAVGALSGAVNANLVKFSTPTSADFTIPGAGTIAVSSGASPDNMRDNNTGTSWLSNNEANPWARIDTGATRLLGAVRIYWGGTSAETPNSFKIQVSDDAVTWADVLSRTAEPALGAYTTYEFNVVYKRYVRVIAQETLAMRINEFHYYTRVTEDAIANHGHGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0I925</accession>
    <name>K0I925_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08540"/>
    <dbReference type="EnsemblBacteria" id="AFU57796">
        <property type="protein sequence ID" value="AFU57796"/>
        <property type="gene ID" value="Ngar_c08540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08540"/>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-852-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="333"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="560" mass="64039" checksum="95C9F513A4769684" modified="2012-11-28" version="1">MEYFYPNDNSRPSHAEKTEVYHGEENAMKILLQAMRNVKKEAVVCSDANSPAFSMGTESVKRGYVDFKKRGVRIRQIVEITKDNLEYCKEFMNYAELRHMDNVKGNMAVSETEYVATAVLEGAKPITQTIYSNVKTFLEQQRYFFENLWSRAMPAEQRIKEIEQNIEPQQIVIIHDAKQALEIYQSLILSAQQEIRIAFPTARAVIRQEKAGIIHLLNKAAERRCRVKILMPNDESVFKFIRKGDANTETRLVAQKDLGKATILVVDNKESLIMELKDDDKETFQEAIGFSIRSNSRPGVLSYVSMFEGLWKQTELYEKMKASDRMKSEFINIAAHEIRTPVQPILGRAEILKEEIESGNYDMESVREAVEMIIRNSQRLHRLTEDLLTVSRIERNVLILNRHDFDLNSVIDNAINDIKNQLQIITKDITILYQPKEKIIVNADKDKITQVIHNLLNNAIKFTDRGTVTIMVEKENKDGSTLFKIRDTGIGIDASLFPRLFQIFATNTIGTSFNQSGSGVGLYISKNIIEAHGGRIWAENNEDGKGATFTFMLPSVKPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0I932</accession>
    <name>K0I932_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase, IS605 OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c08690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57811">
        <property type="protein sequence ID" value="AFU57811"/>
        <property type="gene ID" value="Ngar_c08690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08690"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="WYEMHRQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-867-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="279"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="380" mass="44715" checksum="8DAD846082F22743" modified="2012-11-28" version="1">MYKKMLNYKFRLYPTTKEQELLLEQTLDCCRWVYNYFLDKNMSEYDMNYILTELKEQHPWLHKYYHSKMLQMVAKQVAAARKVAVGRLSYRKDEDFNAFTYNQSGFRIEKDKLVLSKIGSIKIVLHRQPVNVKQVTVCRSKTGKKWYAVVACDVLRRLYSTIIKYTKPAVGIDVGITKFCHDSDNHAVENPQFLTKMLKPLRKAHRRVSRRQIGSNNREKAKHMLARLYERIHNKRHDFLHKKSAYYASHYDLIFLERLKVLNLTKNHRLARKILDASWSAFKNMLQYKANRVIEVEPAYSSVDCSRCGHPVPKSLAVRTHACQKCGAVLDRDYNASLNILQRGLESLMMLLPVERREVTPVEIAQQRSLKQEAHEFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA17</accession>
    <name>K0IA17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalt transporter family protein, subunit CbtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbtB2</name>
        <name evidence="2" type="ordered locus">Ngar_c12260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58166">
        <property type="protein sequence ID" value="AFU58166"/>
        <property type="gene ID" value="Ngar_c12260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12260"/>
    <dbReference type="HOGENOM" id="CLU_168228_1_1_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8036" checksum="C2135F1223413D70" modified="2012-11-28" version="1">MSQRSNQITKTSAGVPKMAVGILLGVLAFGVFMVGFDQGEVFGFTVPADGSGGQPGTNWAHEFYHDMRHAAGIPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBF0</accession>
    <name>K0IBF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58616">
        <property type="protein sequence ID" value="AFU58616"/>
        <property type="gene ID" value="Ngar_c16830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16830"/>
    <dbReference type="HOGENOM" id="CLU_3075478_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1681-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6417" checksum="C8B9750264F28762" modified="2012-11-28" version="1">MSLFTFRTRLQIMQQKIPKQKARHHLLLYDVIEISSKFIYNRKRTVRIENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBL5</accession>
    <name>K0IBL5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56955">
        <property type="protein sequence ID" value="AFU56955"/>
        <property type="gene ID" value="Ngar_c00050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00050"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-5-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="13960" checksum="1D7A20225F768E79" modified="2012-11-28" version="1">MNQTILLVDQKPNTAALVSTYLRADGFSVDHTPDPSEALKFASHMKYRVVITDLVMRGMTGLDLYREIRSYNGEVRFMFLLSVSSDEAIRLMGSLDRDDVIKKEPLSINEVMYKVRAALTNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBP2</accession>
    <name>K0IBP2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17p</name>
        <name evidence="2" type="synonym">rps17</name>
        <name evidence="4" type="ordered locus">Ngar_c17380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17380"/>
    <dbReference type="EnsemblBacteria" id="AFU58671">
        <property type="protein sequence ID" value="AFU58671"/>
        <property type="gene ID" value="Ngar_c17380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17380"/>
    <dbReference type="HOGENOM" id="CLU_073626_0_3_2"/>
    <dbReference type="OMA" id="DPECPWH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_S17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_S17_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="12627" checksum="3F3C3B104BDEFF48" modified="2012-11-28" version="1">MVRNIGVSVISPRKTCEDELCPFHGTLSVRGKLLTGIVSSAKAPKMVVVSREYPRPTPKFKRFQRSRSKVHAYLPPCVDVKEGDEVRIAECRPLSKTVSFVVIEVNNKDGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBX3</accession>
    <name>K0IBX3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rps27e</name>
        <name evidence="4" type="ordered locus">Ngar_c01000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01000"/>
    <dbReference type="EnsemblBacteria" id="AFU57050">
        <property type="protein sequence ID" value="AFU57050"/>
        <property type="gene ID" value="Ngar_c01000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01000"/>
    <dbReference type="HOGENOM" id="CLU_199465_0_0_2"/>
    <dbReference type="OMA" id="TTHINCR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7130" checksum="464DA6FF672D1FDC" modified="2012-11-28" version="1">MKKENIMVPKPRSAFLSVQCEKCGEKAIVFSHTTTNINCKSCGELLAERSGGLANIYGKVLGALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC17</accession>
    <name>K0IC17_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58886">
        <property type="protein sequence ID" value="AFU58886"/>
        <property type="gene ID" value="Ngar_c19540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19540"/>
    <dbReference type="HOGENOM" id="CLU_146467_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1952-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="17131" checksum="E03C9E39E9D14593" modified="2012-11-28" version="1">MTGSNIDRREEKSGVNQRNRRQTTTRTGNGMTMEQLIRETRKEVYRAQKKEAIPNKNKEKSTVRNSMQQQQKVIPREMQRYLTSAAVQVNGGALTAHLQEFCSKIPPGSYRVKVLVRKNNKVTVRMTYRGEEQQQPVQQQPDISTPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC31</accession>
    <name>K0IC31_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58906">
        <property type="protein sequence ID" value="AFU58906"/>
        <property type="gene ID" value="Ngar_c19740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19740"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1953"/>
    <dbReference type="HOGENOM" id="CLU_037493_1_0_2"/>
    <dbReference type="OMA" id="VAVTYCP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1972-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021516">
        <property type="entry name" value="DUF3179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11376">
        <property type="entry name" value="DUF3179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="39978" checksum="AB4954299748DBBC" modified="2012-11-28" version="1">MATVSAAVVVAILVGVMTGKNVLNQGSDYQDRANVNPLSGKDTTKPRSIVPLDQIVSGGPPRDGIPSIDKPRFVSVPEAGKFLQDSDIVLGLDINGDIRAYPLQILVWHEIVNDKVGGVPVAVTYCPLCFTNQVFNRMVDGQTLEFGTSGKLYNNNLVMYDRASESLWSQALGEGIVGKYAGTKLERIPFDLAYWREWKGLYPDAKVLSADTGFGRPYGADPYGDYYTSPSIYFPISNHDSRLGPKEIVIGLEHDGVYRAYQLSKIEEEHVINDDLAGRPVLIASHYQFMTRVFERTVDDQVLEFEYKDGVMTDRQTGSVWGFDGVATDGEMTGKRLQRLPLDQGFWFAWAAFHPGTELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICA0</accession>
    <name>K0ICA0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c20540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58986">
        <property type="protein sequence ID" value="AFU58986"/>
        <property type="gene ID" value="Ngar_c20540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20540"/>
    <dbReference type="HOGENOM" id="CLU_1381443_0_0_2"/>
    <dbReference type="OMA" id="MAMHGFR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2052-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="197" mass="21405" checksum="25CB4E10695E62B6" modified="2012-11-28" version="1">MVDEKKKSTITNLYRYSDLSVEAIAQQVDMDASAVQQIIDNLTREDALEVLIEQSITKVEKIMSPIVISLDVSKTPREAAALMAENQVGSVVVTKNGKPFGIVTQSDIVRWAGKWPKLLDSKLEGIASVPLIKVGRGTSVEEAAQIMMKNQIHKLPVVDGEKLLGIVTITDLAVFLSPSRRPGLALSVLQAISRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICB6</accession>
    <name>K0ICB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57180">
        <property type="protein sequence ID" value="AFU57180"/>
        <property type="gene ID" value="Ngar_c02320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02320"/>
    <dbReference type="HOGENOM" id="CLU_203621_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-232-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="10099" checksum="22D7C4F4A069E22D" modified="2012-11-28" version="1">MTNNADDTQEEKDFRSKYAHELQKKKMQSYANWHFGLDEISDELARVKHQAMITPGRRGEQIKYEEINKEILRRISIGHPVKQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICC7</accession>
    <name>K0ICC7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02520"/>
    <dbReference type="EnsemblBacteria" id="AFU57200">
        <property type="protein sequence ID" value="AFU57200"/>
        <property type="gene ID" value="Ngar_c02520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02520"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-252-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="14088" checksum="A30EB31FB8C93167" modified="2012-11-28" version="1">MKRIAVVDDEPDITIVLKRGLEHHGFAVDTFNDPQAVLASFKPGSYDLMIIDIRMPKINGFDLYRELKKRDGNVKVCFLTAFEIYYEEFRKMFPTIDIRAFIRKPVSISNLVSQVNSTIESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICH1</accession>
    <name>K0ICH1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21460"/>
    <dbReference type="EnsemblBacteria" id="AFU59076">
        <property type="protein sequence ID" value="AFU59076"/>
        <property type="gene ID" value="Ngar_c21460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21460"/>
    <dbReference type="HOGENOM" id="CLU_1324057_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2144-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="23194" checksum="F6EA7E7189C3316B" modified="2012-11-28" version="1">MKQVISVRILGPSMSSDFGGFACYAYVIRDKEGHLPHEAFGLAEKANSQASIASSSIATYTALIRALQWLIHHGYQDEIIIVKSSSKSVVSQLDEAYPSSHQVTESRMPKSVIPLHEKASRLKSKFYKISFESVKSKSGKQSSSDSNEDPADVEERKEIEELLVMAYVEAEEKIMRQNRMLADQNSPFVTVAQLMKYDNNKKQVQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICP5</accession>
    <name>K0ICP5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57410">
        <property type="protein sequence ID" value="AFU57410"/>
        <property type="gene ID" value="Ngar_c04660"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04660"/>
    <dbReference type="HOGENOM" id="CLU_1754761_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-464-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="148" mass="16719" checksum="D27A2B834167543E" modified="2012-11-28" version="1">MTFVVRSLDYKEVPDEVLNSLDSFNNTALKQFGKAVLADRFEDGIIDVVFLRSFSNGIEDLAIIEGNISIAFLSELESIDFISWTLAHELGHTLGLLDVFEFDNLMIRVDGTSMLRFSYRNAYLPSNLTDQQIVIIRNTIEAKSFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICQ3</accession>
    <name>K0ICQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57420">
        <property type="protein sequence ID" value="AFU57420"/>
        <property type="gene ID" value="Ngar_c04760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04760"/>
    <dbReference type="HOGENOM" id="CLU_094092_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-474-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="261" mass="28995" checksum="F06C32C93E3DF01B" modified="2012-11-28" version="1">MIEQNCHAACIVDLDGSGFSAIYSRIHQYLLKGYAVAYVAEDNTATAIQNIKNSGVDVDHFLPTGALQVIDRDLYYNPNKELEPQKLLDQFSKIVTQVDFQKFKGMLGIGSAGPAFFQKGKLEPLLEYEHKIGKRFKVPVEIICCYRSNDIRQLEFSHLVSVITSHAYVITSEGTEHKGLNSDAIISFIAAGINKSLCANISDIILKTLEIAYGIKKERIISQPRIFKNALEKALGITSSRIVLAEIENEIRCALLGDNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICX2</accession>
    <name>K0ICX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57515">
        <property type="protein sequence ID" value="AFU57515"/>
        <property type="gene ID" value="Ngar_c05720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05720"/>
    <dbReference type="HOGENOM" id="CLU_2748315_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-570-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8292" checksum="7E11FBA87071C37E" modified="2012-11-28" version="1">MSKAWRKLIRRQRDDFVHKTSKMLSDEGYTLIVFEKLNINNMVKNHSLASAIMDIYATWAELREYTLPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID10</accession>
    <name>K0ID10_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c06070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57550">
        <property type="protein sequence ID" value="AFU57550"/>
        <property type="gene ID" value="Ngar_c06070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06070"/>
    <dbReference type="HOGENOM" id="CLU_2204191_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-605-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="13044" checksum="2B2020F432965D5E" modified="2012-11-28" version="1">MLKPLRRAHRRVSRRQLGSSNYDKARHMLARLYERINSNSNNNRRRDFLHKLSSYYSSRYDLIFLEKLRVMNMTKNHRLLARKILDASWSLLLKICCYSTRLITSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID15</accession>
    <name>K0ID15_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="2" type="ordered locus">Ngar_c06120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06120"/>
    <dbReference type="EnsemblBacteria" id="AFU57555">
        <property type="protein sequence ID" value="AFU57555"/>
        <property type="gene ID" value="Ngar_c06120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.588"/>
    <dbReference type="HOGENOM" id="CLU_129707_2_1_2"/>
    <dbReference type="OMA" id="FYEVNDA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="122" mass="13339" checksum="2CE0FB7A62B4BFE5" modified="2012-11-28" version="1">MIPGEYVLSSDPVLCNSNRKTIKITVSNKGDRPCQIGSHTHFFEVNRALDFPREKAFGYRLNIPAGTSVRFEPGDSKEVELCEIGGKRICFGFNGLTMGGLNSSIVMRAAVEKARQLGFNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID92</accession>
    <name>K0ID92_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pfdA</name>
        <name evidence="7" type="ordered locus">Ngar_c24370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24370"/>
    <dbReference type="EnsemblBacteria" id="AFU59361">
        <property type="protein sequence ID" value="AFU59361"/>
        <property type="gene ID" value="Ngar_c24370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24370"/>
    <dbReference type="HOGENOM" id="CLU_091867_1_0_2"/>
    <dbReference type="OMA" id="AYMNDIM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="16140" checksum="5EB8630DEF704E1F" modified="2012-11-28" version="1">MAAVEQRINEMVQQSRILEAYMNDIMTRQVTVSRLMEEARLASTTIQNITSESEIESLMPVGVGVYVKTTVPPIKKVVVNLGAGVALEKSREDALNYVESRIKEYEVAARQLDAQRQEIAMRMEQMQAQINQMIRAAQQQQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDV6</accession>
    <name>K0IDV6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c09830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09830"/>
    <dbReference type="EnsemblBacteria" id="AFU57925">
        <property type="protein sequence ID" value="AFU57925"/>
        <property type="gene ID" value="Ngar_c09830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09830"/>
    <dbReference type="HOGENOM" id="CLU_060889_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-981-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="159"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="290"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU57925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="396" mass="46192" checksum="A72E5E9CEC0AB5D4" modified="2012-11-28" version="1">MNRHLLYLLGTSEKDNTKESRTHQLPRLTIKAKVTDDSKTKLELLNREYGAFQAYVQGNTTVQLYSATKQQADRLRNRILRKQKGKINPKKQYPLILRRDLIDVQKDTKFPCVYWMKVPVYPKSIHLRIQTDCRYDLIEYNLREAKVIQQAGSWYIFLCIEKEAEQPSRPPPTNVLAIDLGVHNIAVTVNTANTRPNFYGQKLRAIRGKYFNLRRKLGQKKKAFYKIKALKNREFLQVNHELHKISKEIVEEARRTNAIIVVGKLKGIRKRIKEGGSSRRIRRLVNNFPYYRLVQYIKYKAAWLGIRVMEISEAWTSQTCHHCHEKGERKTQGFFRCKHCGLETNADYNGSMNIMQRALGILSRAGGILTIPIEPLVIADRSKVITGESHMLQRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDX3</accession>
    <name>K0IDX3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26600"/>
    <dbReference type="EnsemblBacteria" id="AFU59581">
        <property type="protein sequence ID" value="AFU59581"/>
        <property type="gene ID" value="Ngar_c26600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2635"/>
    <dbReference type="HOGENOM" id="CLU_029469_2_1_2"/>
    <dbReference type="OMA" id="PMNAIPG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2660-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="201"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="458" mass="51148" checksum="567B65761CECBEB2" modified="2012-11-28" version="1">MENFYHPLSAINAVVDAEMPGLILDLQALIRQPSVSAKKQGLVECANLVAEIMHKAGINSEVLYLDDKSIPPIVYGEVKSKSNPDKTILFYNHYDVQPEEPLELWNDEPFSGKVEGNYIYGRGSADDKGELITRIKAVEYFLKKTGDVPCNVKFMVEGEEEIGSVHVEQYLTKYRDRLLCDGVIWEFGYVDAKDRPIISLGMKGLLYVELIARGPVRDTHSSLAVLIENPAWRLVSALATMRDQNGKILIKDWYKEVRAFTKEELGVISKEPFDEKEFKQEYGIDRFVKNAKGADVKKALVGMPTCNIAGFNSGYTGEGAKTVLPAQATVKIDFRLVPDMVPEKQLERLKRHLKLKGFGDIEVKFIHGEAAARTPIRDPFVRQVQQAARETFGSAITSVSSAGTGPMYSFVKVLKAPCISIGSTYMFARIHSPNEFARIDLLNKTTKCIGRIVEKFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE49</accession>
    <name>K0IE49_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57093">
        <property type="protein sequence ID" value="AFU57093"/>
        <property type="gene ID" value="Ngar_c01430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01430"/>
    <dbReference type="HOGENOM" id="CLU_088365_0_3_2"/>
    <dbReference type="OMA" id="ERSHWHR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-143-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="18704" checksum="012C24138C8BC9AC" modified="2012-11-28" version="1">MMNSQVARRLVKKLALEKHSEGGYFKQTYRSDTMVNVEGFDGPRSIATAIYYMLAGDQFSAFHRIRSDEIWHHYAGGSITLYTIDDKDGGRLSKVKIGGKGGIPQVVIKAGTWFAAALDNRKSYCLLGCTVSPGFDYRDWELGKRDELIRMYPQHRKIIERYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE64</accession>
    <name>K0IE64_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58070">
        <property type="protein sequence ID" value="AFU58070"/>
        <property type="gene ID" value="Ngar_c11280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11280"/>
    <dbReference type="HOGENOM" id="CLU_1607209_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1126-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="17078" checksum="6A11700FB8B6E74C" modified="2012-11-28" version="1">MEMISEMSQKSKQKLTMAAILAIVAVVAMGTTASAIPNAYAATSSRAQCCTSGDFTTTSTSYVDVTGFTTTFNTGSGHSKSAATFTFGNYSPSSTNGQYARLLFDGTERNFVWAANTLHEVGALNSADSVTAASHTWKVQLRALNGGTAAIYASTGVLGVMAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE68</accession>
    <name>K0IE68_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps12p</name>
        <name evidence="2" type="synonym">rps12</name>
        <name evidence="5" type="ordered locus">Ngar_c01590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01590"/>
    <dbReference type="EnsemblBacteria" id="AFU57108">
        <property type="protein sequence ID" value="AFU57108"/>
        <property type="gene ID" value="Ngar_c01590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.158"/>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_2"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="15937" checksum="BF5D2AE3A058A80E" modified="2012-11-28" version="1">MGKSPLGLFAGRVLKSKKSRARWADKYYKRRMLMLDKKANPLEGAPQARGIVLEKVGIESKQPNSAVRKCVRVQLIKNGKSVTAFLPKDGALNFVDEHDEVIIGGIGGSMGGAMGDIPGVRWQVFKVNGVSLNELVHGRKEKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEH3</accession>
    <name>K0IEH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59741">
        <property type="protein sequence ID" value="AFU59741"/>
        <property type="gene ID" value="Ngar_c28210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28210"/>
    <dbReference type="HOGENOM" id="CLU_2565860_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2821-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9510" checksum="BAD51C1B822A18B3" modified="2012-11-28" version="1">MNKKLAFVGLVLMLAAIPLVQFSLDNYGQYLEQQAEAERRALEYADTICFGGRALFPQLYFEASMHTFWQDWLQVQLERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEK9</accession>
    <name>K0IEK9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytosine-specific methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c12450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12450"/>
    <dbReference type="REBASE" id="55358">
        <property type="entry name" value="M.Nga92ORF12450P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58185">
        <property type="protein sequence ID" value="AFU58185"/>
        <property type="gene ID" value="Ngar_c12450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12450"/>
    <dbReference type="HOGENOM" id="CLU_1507433_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1243-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="19844" checksum="0CEB251CF399C1D0" modified="2012-11-28" version="1">MNDGPTFIDLFCGAGGFSLGFVKAGFKHVLGVDNWNTVCETYQANIGNAVCQDLRIFDGKPFVGKIDVVIGSPPCQTFSSANTKTRECNTELCDEFMRIVNEVKPKVWIMENVPECIDYVQAPFKEVFYAGDFGVLQGRERAFFSNIKLKPDKIGQKYLDTEQSAKQLCLKSQQSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEL1</accession>
    <name>K0IEL1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59791">
        <property type="protein sequence ID" value="AFU59791"/>
        <property type="gene ID" value="Ngar_c28720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2848"/>
    <dbReference type="HOGENOM" id="CLU_1286378_0_0_2"/>
    <dbReference type="OMA" id="HAHIPDP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2872-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="225" mass="24005" checksum="2B8AB31167C8F130" modified="2012-11-28" version="1">MTSSFNITRDRLKLAAVAIAVASTAILLTIYGSTTVFASHSFEAGVSGDNIPDNTHIRLDGLTLPPAGVLPVYDASPNFISGHFLLRAPCDPETHVPYVTVIAGHIDESEHGTYVDKVPLYYIAHASTAGSCVFHAHIPDPLNGGAARVTDIVLINLSGQNVTFNAGDVVDVNVQRVLGSISDAPYDEMKLPGSLEHGNPVFDLNDDNPNNDGLGFVHEMEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IES4</accession>
    <name>K0IES4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c13220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13220"/>
    <dbReference type="EnsemblBacteria" id="AFU58260">
        <property type="protein sequence ID" value="AFU58260"/>
        <property type="gene ID" value="Ngar_c13220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13220"/>
    <dbReference type="HOGENOM" id="CLU_069356_15_12_2"/>
    <dbReference type="OMA" id="AGLEVMY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1320-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="22164" checksum="2D5D82E30AA0991C" modified="2012-11-28" version="1">MPKVTSMYKAEVKEKIIRAAIDSFAQTGFDRTKMEDIAKRLGLSKGTIYLYFKSKEDLFLAICEHNMQQSDREDAGLFVRKDNIASDAEQIYDNIRRREQGNDRVMLEMVAESARNPKLKKAMYELHVKVHEHVMQAVKSKIDEGFLRKDVDAASLAIALVALYDGLAVNRMLGISDAVNKKAWVTMIKTMIAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEV0</accession>
    <name>K0IEV0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">lysS</name>
        <name evidence="9" type="ordered locus">Ngar_c03750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03750"/>
    <dbReference type="EnsemblBacteria" id="AFU57323">
        <property type="protein sequence ID" value="AFU57323"/>
        <property type="gene ID" value="Ngar_c03750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03750"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.362"/>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_2"/>
    <dbReference type="OMA" id="DWPMRWA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="40"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="296"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="538" mass="60531" checksum="009F7B23E7392CEE" modified="2012-11-28" version="1">MEEQIGKGTWIDKVADILIKREKKLGRSLDLIRVESGLGASGIPHIGSMGDAVRAYGIALALQNFGFKSELVAYSDDMDGLRKIPHGLPDWLQEHIARPVSSIPDPFGSCHASYGAHMSSLLLDGLDKAGIKYRFQSGREAYKQGLLVNQIDTILKSSAKLGQKIAEFVGQDKYIEVLPYFPVCHNCGRLYTAVAQKYLPDEKKVTYVCSGSRIGKADVKGCGHRGEADIAKGEGKLAWKVEFGARWAAFDIRFEAYGKDIMDSVRVNDWVADEILGYAHPLHVKYEMFLDKSGKKISKSAGNVLTPQMWLRYGTPESILLLLFKRITGTRHVGLDDVPVLMKEYDDLEDIYFGRVKVDNPAKLVKDRGLYEYINKLQPPKQPGPHVSYQLIAQQAAIFPSGEEDRYDKIFNRLVTYNIAKDKTDAIMQKIRLASNWADDNMAREEKFDIKLSDAQRKAIIDLIEAIKPFAGMQSTPDNAKELQSKVFDVARNNGMEPKEFFTLLYRMFLNADRGPRIGNYFLDLGIDRAISVLQRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEX0</accession>
    <name>K0IEX0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tyrS</name>
        <name evidence="10" type="ordered locus">Ngar_c29880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29880"/>
    <dbReference type="EnsemblBacteria" id="AFU59906">
        <property type="protein sequence ID" value="AFU59906"/>
        <property type="gene ID" value="Ngar_c29880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2960"/>
    <dbReference type="HOGENOM" id="CLU_035267_1_1_2"/>
    <dbReference type="OMA" id="YIGFEIS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="349" mass="39750" checksum="E1AD6E70E898AFB7" modified="2012-11-28" version="1">MDIEERLALVTREPTEEVVTADELRALLESKAHPKHYIGLEISGVLHLGSLVLTGFKINDFIKAGIHSTVFLADWHTYINDKLGGDWDRIKKVSQYYAEAFKFFCPGVNVVLGSDLYRQTDSYWEDFVRFSKHMTLARTMRSLTIMGRSEAEKNLDLSQLLYPPMQSVDIKALDLDIVHAGMDQRKIHMLVREIFPKLGWKVPVVVHHHLLPGLSEPVRAGLDENAAEDARISSKMSKSKPASGILIHDDEKTIRDKISKAFCPVGVAEGNPILELVRYIVFHQFDEFVIERPAKYGGNMTYTSYKDVERDFVAKKIHPMDLKNATATYVNKIIEPVYRHFKGREPAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF92</accession>
    <name>K0IF92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60036">
        <property type="protein sequence ID" value="AFU60036"/>
        <property type="gene ID" value="Ngar_c31200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31200"/>
    <dbReference type="HOGENOM" id="CLU_2875215_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3120-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7233" checksum="B1A4C040C2A3F549" modified="2012-11-28" version="1">MFELSKNISADRSNNFKKEEGLYPLQQFNKTARRKQQVWQAQKDNFLSKASSKSKLGSACIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFA8</accession>
    <name>K0IFA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57513">
        <property type="protein sequence ID" value="AFU57513"/>
        <property type="gene ID" value="Ngar_c05700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05700"/>
    <dbReference type="HOGENOM" id="CLU_3057244_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-568-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5982" checksum="F5E5AA0107998F47" modified="2012-11-28" version="1">MYRIPVGTLKRCTIIRDVNQWYCVIIIDDGIDKPITDHGTNKKPVGIDVGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFC1</accession>
    <name>K0IFC1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60066">
        <property type="protein sequence ID" value="AFU60066"/>
        <property type="gene ID" value="Ngar_c31500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31500"/>
    <dbReference type="HOGENOM" id="CLU_3094236_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3150-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5887" checksum="2C7827DC3566C4B3" modified="2012-11-28" version="1">MEFLMRSLIPKNIKDNAANKVEPQSTRKRKYVTAAFFASVTLILYLLGWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFJ1</accession>
    <name>K0IFJ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal A1A0-type ATP synthase, subunit F</fullName>
            <ecNumber evidence="4">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpF</name>
        <name evidence="4" type="ordered locus">Ngar_c16470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16470"/>
    <dbReference type="EnsemblBacteria" id="AFU58580">
        <property type="protein sequence ID" value="AFU58580"/>
        <property type="gene ID" value="Ngar_c16470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16470"/>
    <dbReference type="HOGENOM" id="CLU_135754_3_0_2"/>
    <dbReference type="OMA" id="EINRMDE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="10839" checksum="B33E83C09B033615" modified="2012-11-28" version="1">MRIVAIGSRVFVTSFQLAGVKGVKVETPSEALTEINRMDENSGIGLVLLSDDIGKEIRYQLTSLRAKRPIPLIFELPSPGSKKERVDYRALLKQILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFP8</accession>
    <name>K0IFP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57658">
        <property type="protein sequence ID" value="AFU57658"/>
        <property type="gene ID" value="Ngar_c07150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07150"/>
    <dbReference type="HOGENOM" id="CLU_178999_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-713-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11830" checksum="E6CBD06AE51BB199" modified="2012-11-28" version="1">MLFLILATHSPDMCPLTNSKVREHVLKAVPEWKNMAEKLGVKLVSEPLVNNEHMVTCVVEAQDVETLDEFINQSGMQQWNNVKMIPSTPIENAIKKYDEVKPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFP9</accession>
    <name>K0IFP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60176">
        <property type="protein sequence ID" value="AFU60176"/>
        <property type="gene ID" value="Ngar_c32610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32610"/>
    <dbReference type="HOGENOM" id="CLU_2784243_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3261-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7899" checksum="EE703E329B25F0BD" modified="2012-11-28" version="1">MAVSSLVLAVPEQEFHQEMNKINNWLVELRSLGVDAKSRNDLNNEKELQDATDNIKRSLYEEYKKAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFU6</accession>
    <name>K0IFU6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57678">
        <property type="protein sequence ID" value="AFU57678"/>
        <property type="gene ID" value="Ngar_c07350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07350"/>
    <dbReference type="HOGENOM" id="CLU_2103583_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-733-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="115" mass="13019" checksum="3876B0C917409603" modified="2012-11-28" version="1">MSSPYPTQEDELRAKEAQAEDVKKAEETKFLSTFQSVPKRNGETLAKLANAIVSSFNSVMAESRLKPFERQEDIMAGMKKLFEEQINVIEARRVYTIKINPSTAMKEEQESKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG26</accession>
    <name>K0IG26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ferritin, Dps family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60361">
        <property type="protein sequence ID" value="AFU60361"/>
        <property type="gene ID" value="Ngar_c34460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34460"/>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3447-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="163" mass="18129" checksum="B75F34FE73F3BE47" modified="2012-11-28" version="1">MGRTEKRILGKNAAKIIEILKSAYCDEMRIFHYFWYVGINMEGIGLVTYAAALKTQATGELAHAELLADRIAELGDLAPSNPSEWAKYSTIGLLDPAKHLTLRAALERALQFEGKAVENYNNLAKKALTLGDYVTYNLATTILADEVKDEQHTEDILKSLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG27</accession>
    <name>K0IG27_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">cbiD</name>
        <name evidence="7" type="ordered locus">Ngar_c18070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18070"/>
    <dbReference type="EnsemblBacteria" id="AFU58740">
        <property type="protein sequence ID" value="AFU58740"/>
        <property type="gene ID" value="Ngar_c18070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18070"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1785"/>
    <dbReference type="HOGENOM" id="CLU_041273_0_0_2"/>
    <dbReference type="OMA" id="YHGKLIK"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="385" mass="41261" checksum="7C52B54A6156B088" modified="2012-11-28" version="1">MFAEDKDLELAEQEQELPPEIEEKRRKGALRTGYTTGTTATAATKGALYALIEKPVEQVTVSLPKGKTATIKIAWTRIDGNKATCAAIKDGGDDPDVTHGAEICSTVSLSDNAGQINIDGGKGVGRVTKPGLGLEIGKAAINPIPMKMLEQAVREVAQDQLKKHGVEVVISVPKGEEIAKRTDNPRLGILGGISILGTTGIVLPYSTASFAASIRQGLDVAIAMGADTTVLTTGGRSEDFAKTLFKLPDHCFVQMGDFAGYSIKQCASKKLRKAIIAGFIGKLTKMAMGVKQTHVAGSHVDMEFMARLAAECKAPPEVVQEIRGANTARHVSEIITKNNVAGYFDLVCKKVHEQMSEHSKRQLDIEVVMFEFDGQVIGRHPPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG88</accession>
    <name>K0IG88_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA methylase N-4/N-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60416">
        <property type="protein sequence ID" value="AFU60416"/>
        <property type="gene ID" value="Ngar_c35030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35030"/>
    <dbReference type="HOGENOM" id="CLU_2257458_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3504-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="11761" checksum="87366D0BB3389D02" modified="2012-11-28" version="1">MKDIRELTAVVAKQRAAIGIFITLSEPTSEMIKEVKATDPYVMKTWNHKYPKIQILTIEQLLRGIRADIPPTSSAFEQALIAKRHQARRTSDLMICNHNTSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGB1</accession>
    <name>K0IGB1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57863">
        <property type="protein sequence ID" value="AFU57863"/>
        <property type="gene ID" value="Ngar_c09210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09210"/>
    <dbReference type="HOGENOM" id="CLU_096330_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-919-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="23564" checksum="5A63E61B0E43E45B" modified="2012-11-28" version="1">MAAKSLAPIKRRSHVAVWKWVQKYADCADRYRTDRRLVSTIFVDETLLQIDGHDYSTGCGLHMNHLQSIRVWPCTSHVTEPFSCATGSSSSCKGGRGRKPIFTDGARWYNEACRWLRLPHLVYGTELKNLMVEQFIQQVKDDRTQNVSTTIFHVEKRQIATGGMCGTGSGCSSYICTWEQTGCGSHYFWLGMEVKLTGPFPIVKILYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGB4</accession>
    <name>K0IGB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c19080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19080"/>
    <dbReference type="EnsemblBacteria" id="AFU58840">
        <property type="protein sequence ID" value="AFU58840"/>
        <property type="gene ID" value="Ngar_c19080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19080"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1892"/>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_2"/>
    <dbReference type="OMA" id="SICPHER"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1906-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="24751" checksum="45D53E91628D3671" modified="2012-11-28" version="1">MTFGYHRAEVLAALANGVALSVISIWVLYEAFLRVMSPRLIDTPLMLAAAGIGLAGNLAVMFLLKHHAGKSINIQSAFVHVVYDAVSSVAVIITGFIAMYMGITIVDPLVAFLIAGLVARSAYTIVRSSTHILLEGAPRELDIQQIISTLKQLDGVVDVHDLHVWTISTGMDALSGHVVVRDQMLSQSSKLLDDINKVLADRYNITHTTIQLENEQKVSFKRTLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGE9</accession>
    <name>K0IGE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60471">
        <property type="protein sequence ID" value="AFU60471"/>
        <property type="gene ID" value="Ngar_c35580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35580"/>
    <dbReference type="HOGENOM" id="CLU_2353301_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3559-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="96" mass="10972" checksum="03D0605788EA85CD" modified="2012-11-28" version="1">MIYVCSQIWTQKHQHKMAEDSNLRYRKRKQTIEGALEVLGPQAREIILAYLLHQKKIIIGNDYCSPIAEIEASLRELLGGTTLIVHSIVTRERGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGM7</accession>
    <name>K0IGM7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c20430"/>
    <dbReference type="EnsemblBacteria" id="AFU58975">
        <property type="protein sequence ID" value="AFU58975"/>
        <property type="gene ID" value="Ngar_c20430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20430"/>
    <dbReference type="HOGENOM" id="CLU_1954736_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2041-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13579" checksum="9E4EE632303F4EB7" modified="2012-11-28" version="1">MPLTGEEIVYRYFKCIDSKDLNGILDLFDYDAVIHEPFSNIPEGLKGRSSIEPFLKVAMMANSSLQRTIKIEKPSKPDANKITALITFEKGDKVKGRFTFEFENDTAGAKKIKSLNIEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGQ1</accession>
    <name>K0IGQ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 1A</fullName>
            <shortName evidence="1">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eIF-1a1</name>
        <name evidence="1" type="synonym">eif1a</name>
        <name evidence="4" type="ordered locus">Ngar_c00420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00420"/>
    <dbReference type="EnsemblBacteria" id="AFU56992">
        <property type="protein sequence ID" value="AFU56992"/>
        <property type="gene ID" value="Ngar_c00420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00420"/>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="OMA" id="ADITWRY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU56992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="89" mass="10133" checksum="BCF7F4EC5D1B5C9A" modified="2012-11-28" version="1">MVMPGDGQLFGKVIKLVGGDNIIVKCTDGKVRTCRIRGKIKRRMWIRDNDLVLIAPWDFQSDKADIIWRYIAAHAEKIKQDGHLTGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGQ4</accession>
    <name>K0IGQ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56997">
        <property type="protein sequence ID" value="AFU56997"/>
        <property type="gene ID" value="Ngar_c00470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00470"/>
    <dbReference type="HOGENOM" id="CLU_1830646_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-47-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15256" checksum="E85944B08BA52C81" modified="2012-11-28" version="1">MDRALKALGTTTISSMAEETITVSCAGDSQLAAEIYNHLCSKVGKADTGYISLVEDEIGIDRRSTLTKDAVRQILDSFVRSNPERLKNHQVIESGDIFVVGIVAEPSKVDALLTCEFCGYFTPYQEDLFIHKRMHAGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH46</accession>
    <name>K0IH46_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="4">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="4">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">folD</name>
        <name evidence="7" type="ordered locus">Ngar_c22600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="4"/>
    <dbReference type="EC" id="3.5.4.9" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22600"/>
    <dbReference type="EnsemblBacteria" id="AFU59190">
        <property type="protein sequence ID" value="AFU59190"/>
        <property type="gene ID" value="Ngar_c22600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22600"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2238"/>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_2"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="6">
        <location>
            <begin position="123"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="287" mass="30891" checksum="28ACB1C370F02B4C" modified="2012-11-28" version="1">MVARIIDGKVVSADVKARVKKAVEQLKDNGVQPCLATVLVGDDPASATYVGSKQSDAKEVGIATRDHRLTSTFKQSELVELMQLLNNDHEVHGILVQLPLPKHIDEFEVIAALSPFKDVDGLTPYNAGMLQSGMGVLKPCTPSGIIELLDYYKIDITGMDAVVVNRSNLVGKPLALLLLERNATVTICHSKTKDLNAKLHNADLVVTAVGNRQRFTLTGDMIKEGAIVIDVGIARLNNKLVGDADFESVKQKASWVTPVPGGVGLMTRAMLLKNTVTAASISKEMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR0</accession>
    <name>K0IHR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15490"/>
    <dbReference type="EnsemblBacteria" id="AFU58483">
        <property type="protein sequence ID" value="AFU58483"/>
        <property type="gene ID" value="Ngar_c15490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15490"/>
    <dbReference type="HOGENOM" id="CLU_065731_0_0_2"/>
    <dbReference type="OMA" id="TWMISAY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1547-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="277" mass="31152" checksum="589003630F735F89" modified="2012-11-28" version="1">MDNSIPRLIIKLKNEFVRTYRGQSLLREVLPLPNSRYLPVDDDVLHSLHQFAAANLIYFRSYDSEISGIACKVYEGDINNYWLNSKKYDTSYQPFYPTWILSAFALAHGAKSLGFEQLVDVGSGDGRIAYCGRLLGMESHGIEIDYDLVQLQNSISAATGIRYSAIRADATRFDYKTLKLSKPIFFISGLPEMGEMLANSVISQAKSIEGLMHNSAGFNFMGSHVMKSFSRDQTGWGWGSVIANHDLELVDTVTLPTLWTTDQVVDTAYVYTRFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR2</accession>
    <name>K0IHR2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04250"/>
    <dbReference type="EnsemblBacteria" id="AFU57372">
        <property type="protein sequence ID" value="AFU57372"/>
        <property type="gene ID" value="Ngar_c04250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04250"/>
    <dbReference type="HOGENOM" id="CLU_082268_3_0_2"/>
    <dbReference type="OMA" id="TGMYRPE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-424-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="12318" checksum="03AF6DABB2C813F2" modified="2012-11-28" version="1">MKKIEAVVPAARLDRAFAALKELDLGGFTYYDSKGRGQIPRQEVHSGRGTGMYRPEFNVNSTIVVVTKDSMADKVIDKILQSTSTGLAGEGKIFVSDVDEAIDIGSRQRGEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHX3</accession>
    <name>K0IHX3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemL2</name>
        <name evidence="7" type="synonym">hemL</name>
        <name evidence="9" type="ordered locus">Ngar_c26130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26130"/>
    <dbReference type="EnsemblBacteria" id="AFU59535">
        <property type="protein sequence ID" value="AFU59535"/>
        <property type="gene ID" value="Ngar_c26130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26130"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2585"/>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_2"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="425" mass="46117" checksum="F5D483EF135F3379" modified="2012-11-28" version="1">MNRSEQLFGRAKKVLPGGVNSPVRFYEPYPFFATSARGSKLTTADHKTYLDYCMGYGAMVLGHGYSSVIEAVRSQLDNGTLFCVPTEREIKLAEMICKVVPCAEMARLLNTGSEATMHAIRLARAFTKRKCVIKFEGGYHGAHDYVLAKAGSGAASMPASEGVLEEASAQTAVVPYNDPAALERAIEKNRDTACVIIEPVLANIGLVLPEKRYLNEVRRITEQNDVVLIFDEVVTGFRLQLGGASEFFGIKPDLAAFAKALGNGLPIAAIAGKREIMSKLAPAGAAYQASTFAGNSVSVAAAIATLETLIEAKNAIYPKIARTCDSIVDGIKDALSAAQLDCTVNSIGSMFQLFFTGEKVKDEASAKKSNAAIFRRLFDELLKRDVFIPPSQFETCFVSYAHSEDDADKTIEAYSEAFRRIKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0II08</accession>
    <name>K0II08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58568">
        <property type="protein sequence ID" value="AFU58568"/>
        <property type="gene ID" value="Ngar_c16350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16350"/>
    <dbReference type="HOGENOM" id="CLU_2581534_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1633-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9251" checksum="3C7DF22EBCB42E89" modified="2012-11-28" version="1">MTLLWRDSWLKPLSDFDVGADKCGYCKKAFRKIDFVTACDFCDKGIMHDACANKHILSAHKKQLEAKINLHKDKPLHDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0II49</accession>
    <name>K0II49_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase subfamily</fullName>
            <ecNumber evidence="4">3.5.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c07140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.10" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c07140"/>
    <dbReference type="EnsemblBacteria" id="AFU57657">
        <property type="protein sequence ID" value="AFU57657"/>
        <property type="gene ID" value="Ngar_c07140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07140"/>
    <dbReference type="HOGENOM" id="CLU_2392983_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-712-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047789">
        <property type="term" value="F:creatininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10332" checksum="C7BF8A6AB617D1AD" modified="2012-11-28" version="1">MGHGSEGETSVMLAVRPDLVDMTLAPQEVVPKLPDNIKIYWKFNELTTTAATGAPRKATAKKGQKIMQILENVLLGFITDMDKNQWKYGNARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0II78</accession>
    <name>K0II78_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl3p</name>
        <name evidence="6" type="ordered locus">Ngar_c17300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17300"/>
    <dbReference type="EnsemblBacteria" id="AFU58663">
        <property type="protein sequence ID" value="AFU58663"/>
        <property type="gene ID" value="Ngar_c17300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1704"/>
    <dbReference type="HOGENOM" id="CLU_033361_2_0_2"/>
    <dbReference type="OMA" id="HQRTEYN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="36606" checksum="D67FF3D62E41183E" modified="2012-11-28" version="1">MGHRKYSAPRRGSVAFRPRARARSLEARVRTWPQLAAEKSSLLGFAGFKAGCIHVLTIDDREKTPNFGKQLLNPATVIVTPPIRVIGIRGYKKDIYGQHAIFDVYAKDLPKELSRKFDAKSSDEAFAKAEGMLGSASAIMAIVAVSPNSIGLSQKTPFVFEMAVSGKDAKSQYDYVKSVLGREVKVSDIFQVGQNIDVFGITRGKGIEGPVTRFGIKRKQHKSRKSVRAVGTLGPISPAVVMYTVARQGQRGFHQRTEYNKRILVMSNTEKDGQNSINPSGGFKHFGLVKGDYIIVRGSVPGVPKRLIKMRQPIRNVSKKVLEPKVLEVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA6</accession>
    <name>K0IIA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57742">
        <property type="protein sequence ID" value="AFU57742"/>
        <property type="gene ID" value="Ngar_c08000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08000"/>
    <dbReference type="HOGENOM" id="CLU_3210874_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-798-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="44" mass="4927" checksum="3E880C7F338F0EC4" modified="2012-11-28" version="1">MSMTRGMPRVISLQSGKSNENVIRDHKIGMIRRNSLSINPSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIG4</accession>
    <name>K0IIG4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57847">
        <property type="protein sequence ID" value="AFU57847"/>
        <property type="gene ID" value="Ngar_c09050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09050"/>
    <dbReference type="HOGENOM" id="CLU_1329512_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-903-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="206" mass="23308" checksum="07D2EA4B2995E711" modified="2012-11-28" version="1">MRHTYILLTDSRSISGKSYPLSRHRFCLLYFRGRCRLTTMLSSVSAAAFMSCVLAPSTTTPMGTPLPSTRRLLLVPDLALSVGFGPVLFSPEGRFCHHAIHRLPFPVDSFLYVVFQQALDPHAPEHTSLPPLLEPVKYGGRCAQAARERVPLAASTQDVEDGTHCFPVVHPWTASLLLFLWWRQQWHYPLPQNIRYFVQTVNSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIP3</accession>
    <name>K0IIP3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenosine 5'-phosphosulfate reductase</fullName>
            <ecNumber evidence="5">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c10300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10300"/>
    <dbReference type="EnsemblBacteria" id="AFU57972">
        <property type="protein sequence ID" value="AFU57972"/>
        <property type="gene ID" value="Ngar_c10300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10300"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.980"/>
    <dbReference type="HOGENOM" id="CLU_044089_1_0_2"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1028-MON"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="9">
        <location>
            <begin position="39"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="28417" checksum="DC1299ACA2CE2A60" modified="2012-11-28" version="1">MGPKFTPTQIEKLADEFEAKSAEEVLKWALDNFGTKIGLASSFGAEDVAIIDMMTKINKEKTKVFTLETGRLNQETYDVMDAIRARYGIQIEAYFPDQKEVEEMIRSKGMNLMYESVENRKLCCEIRKVHPLNRALATLDGWITGLRRDQVATRATTKKIELDAVHGGIIKLNPIADWSSDRVWDYIRKNNIPYNALHDKGFPSIGCEPCTRAVQPGEDPRAGRWWWENAAAKECGLHFDPTKKKQQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ13</accession>
    <name>K0IJ13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58132">
        <property type="protein sequence ID" value="AFU58132"/>
        <property type="gene ID" value="Ngar_c11920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11920"/>
    <dbReference type="HOGENOM" id="CLU_2911649_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1190-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6776" checksum="0571D6DBB179A311" modified="2012-11-28" version="1">MVHNNLRKPFEHIIIIANPMTPPSTAIMNAGNSGTMVYSVLSIFNDAEKMFLEFGFPMTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ54</accession>
    <name>K0IJ54_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58212">
        <property type="protein sequence ID" value="AFU58212"/>
        <property type="gene ID" value="Ngar_c12720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12720"/>
    <dbReference type="HOGENOM" id="CLU_2044303_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1270-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14533" checksum="378A993F77C74DFA" modified="2012-11-28" version="1">MSEDHHQRLEQTASAIEDLLYMEVIKLGDEQDKALLSPHFSIVVSNVMANMKLNEDAGSSDTMKLMYYSLLIYMNEHLKMPKPLIMALGNDLEKNRESMESGKLITTYVAVLSEIWAQNRRQANNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJA2</accession>
    <name>K0IJA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31790"/>
    <dbReference type="EnsemblBacteria" id="AFU60095">
        <property type="protein sequence ID" value="AFU60095"/>
        <property type="gene ID" value="Ngar_c31790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31790"/>
    <dbReference type="HOGENOM" id="CLU_736932_0_0_2"/>
    <dbReference type="OMA" id="GASWDIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3179-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="358" mass="37461" checksum="D5B54612146EB3A1" modified="2012-11-28" version="1">MNYFKQSPAQSIIGSSSRFLASYVLVSLGVLLAAGGGSWDISNHLLNKPETFFAPPHAVLYSGAGAAVVGAIILFLTSRRAGAMIIRPIKLVVAGVIILVVAGPVDFAWHSAFGLDGLLSPPHFVLVSGMVASSIGSLAGMVYYGSMAFKESRLPPLLIIIGVLPVWLAVSGIVDMFSLPFSKTDYFNFNPHPTLGVAVATLGFPAVISVLACSSSALAGRRFGVMTAVGAAFIVTGMLTSIVPNDALVQTLLFYAATNIIPFIAADAVLSFSRSKISLYAAGAIVGLAFFTLYYPLITYTYGEALGRTTIWPSLIAITYFEIMGTVMPLMVAPAAAMGILGAAVSAKLVSKNKALEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJM5</accession>
    <name>K0IJM5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative signal transduction histidine kinase, with PAS, phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c24860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24860"/>
    <dbReference type="EnsemblBacteria" id="AFU59408">
        <property type="protein sequence ID" value="AFU59408"/>
        <property type="gene ID" value="Ngar_c24860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24860"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_2"/>
    <dbReference type="OMA" id="YPAHEIV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2484-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="387" mass="42716" checksum="91A3CD28C4F3391B" modified="2012-11-28" version="1">MEQKADRSLEDGRGYPNTYLRTYWILESLYESSPVLYCVVNAAGTILDCNETYARRVGYSRAESVGRSIFNHVGPNSLVAMQEYLEAWEKKGLVENCEVWLKKKDGSVFPALLSAASVHDERGRVVACNIALIDQTDIYKTKRDVEKANEELKIKEQLKNEFIAIASHELRTPIQPLLGYAILAKKGKISQEAAWEGVLREARKLQQLANDILDVSRIESGSLMYQMEKVAINDLLVGVVDSAKTNLAKDVTMDLVIDDASRSLEVNLDRSRITQVLSNVIGNAVKFTEQGSIKVECRAFPGKNRVEIRVIDTGTGIPEQVLPNLFGKFVTKSTGDTDGHGGTGLGLFISKAIVTAHKGEIYGYNNATGGATFTIVLPIDQSNIIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJP1</accession>
    <name>K0IJP1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59438">
        <property type="protein sequence ID" value="AFU59438"/>
        <property type="gene ID" value="Ngar_c25150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25150"/>
    <dbReference type="HOGENOM" id="CLU_1444623_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2514-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="18352" checksum="AB09B0B523328C1B" modified="2012-11-28" version="1">MGAAALVALVIIPALAPPPPPHTVCLRGEEGIETFQLHPRIEVIVDGRNMMLPDDVGKQPKDGEECRRPIHTDEVGNVVHIEYIRPVRLTLGNFMDVYNINNTITVVDNSTGTNVERTLNLTDYDIAYSYFSEAGEFTRVASPYETPAFPQDNKMVARIELTSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKG6</accession>
    <name>K0IKG6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58917">
        <property type="protein sequence ID" value="AFU58917"/>
        <property type="gene ID" value="Ngar_c19850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19850"/>
    <dbReference type="HOGENOM" id="CLU_1192654_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1983-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="232" mass="25230" checksum="5DAF7DAB1D72D47D" modified="2012-11-28" version="1">MPEVIRSLWFEEIGFLHEKFFDTPIGKLTVRQVAIVFVFGISAWAAFNSVGDDMLKVAVTSLLVILGLAFAFQRIKTLTPEQSMVFALFAPKTGAGGTGRTKKNKIPILTLPVNSVHGGSETIDISMLDAGDDVHDAQMQKLVVLVRDPQTGSPLPNRGCEILVEGKSIGRRLTDEEGFLTIPLVPKLGINTIEVKPDGYAAIVKNVTVDVHMRQQAERPHSATKTAQGARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKJ7</accession>
    <name>K0IKJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59803">
        <property type="protein sequence ID" value="AFU59803"/>
        <property type="gene ID" value="Ngar_c28840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28840"/>
    <dbReference type="HOGENOM" id="CLU_3075482_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2884-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5793" checksum="682DADF15EFD0CB2" modified="2012-11-28" version="1">MSNDNNRAKTYLCVYQMLAITAGDVSWLALVIALSVGVTFAILYLLRSWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT2</accession>
    <name>K0IKT2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c30470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30470"/>
    <dbReference type="EnsemblBacteria" id="AFU59963">
        <property type="protein sequence ID" value="AFU59963"/>
        <property type="gene ID" value="Ngar_c30470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30470"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3016"/>
    <dbReference type="HOGENOM" id="CLU_029695_1_0_2"/>
    <dbReference type="OMA" id="YKMFIRW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3047-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="411" mass="47179" checksum="1DC5BAFC07FEC7DF" modified="2012-11-28" version="1">MIYSTIVPIHSVLILIVAWGVYRDPAKGQVSNDLVSVVIPIYNQKSMIRLVIDSIFQSTYQNIEVIAVNDGSKDGTKEVLDELAHKYPKLKVLHKKNAGKRKAIGTGFMMSRGKYVVFIDSDSIVHRNAVEQFVKTFNSDKQIGAVVGNAKVWNASKNIMTKLQSVWYDVQFNIHKTCESTFGLVICCSGCLCAYRREAISEFIPRWTNAKVIIGDDRELTSFVTAKPWSKPELLSHFAQTNLDRASRYDDAEDRVLTAQTLVQWKAVYVASAVVFTDVPEKFKGFIKQQVRWKRGYLRAQFFVSSFFWHNNPLMVFIFYLEFMASLTMPLIIFTVLVYEPFFRGEYMFSIFFAASHLVTGLIEALDSKFRNPNDSVWKYKPMMNVLSTTVLSWLVIYSWLTLKTDKWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL81</accession>
    <name>K0IL81_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33030"/>
    <dbReference type="EnsemblBacteria" id="AFU60218">
        <property type="protein sequence ID" value="AFU60218"/>
        <property type="gene ID" value="Ngar_c33030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33030"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3293"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="WRHPDEP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3303-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="32"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="294" mass="32996" checksum="B3DBF4EFF6FE7A95" modified="2012-11-28" version="1">MEKCTDKAIMSSSTITVPKRKFGWTGVEVPVVGQGTWMIEGNTAPVASRRHAVEALRLGLDLGLTHIDTAEMYGNGRVEEIVAEAVAGRREQVFLVSKVLPSNASYEGTIAACRRSLKRLRTEWLDLYLLHWPSGYYPIKETMRAMEKLADDGLIRFIGVSNFDVAQLEEAQQALSKYRIACNQVPYNLSDRQVELDLLPYCADRHIAVVGYSPFGHGYYFPSPGSRQGQLLADIGRRHGRTPRQVVLNYLIRHPETFTIPKARRPEHVIENSRGAGWSLTEKDIAAIDRAFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA5</accession>
    <name>K0ILA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60278">
        <property type="protein sequence ID" value="AFU60278"/>
        <property type="gene ID" value="Ngar_c33630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3352"/>
    <dbReference type="HOGENOM" id="CLU_202921_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3363-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8510" checksum="D711AF9789D17C30" modified="2012-11-28" version="1">MVRKFDDWWRTVPADLKTKARKGDEANKPLLNQINYVLLHLHLAGKHDLKPTHEELKDWLHSGQVDVLRMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILA7</accession>
    <name>K0ILA7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c00240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00240"/>
    <dbReference type="EnsemblBacteria" id="AFU56974">
        <property type="protein sequence ID" value="AFU56974"/>
        <property type="gene ID" value="Ngar_c00240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00240"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.26"/>
    <dbReference type="HOGENOM" id="CLU_023341_0_0_2"/>
    <dbReference type="OMA" id="NKDETYF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-24-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="117"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU56974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="690" mass="74256" checksum="287C2EDE8FDAD3E9" modified="2012-11-28" version="1">MSFDSQAKDSKKGGVLESASKRVRMIFSVMASPNRIDILRILNTKGPLTYSELKALAGFKSKKESGKFAYHLRKLLRQLLVALNKAERRYTITNLGKLVLSLARQIEERSIIESGKMYVRTSRHTIEEFNSHKIIQSLVREANLPLEQAHKITEEVENKIYKFQTAYLTSSLIRETVNSVLIEHGHEEYRNKLARVGLPSSDIVEMLSAEGATVDSVMAKTAGSVFSEYLVFNTLPKDIADMHLAGEINISNAGVWGLLPDTVFFDLSELEEGLDLKGRFLNVARIPAIKSPDDVIAALPALVSLLSREASSEVVIEGIVPALLKNLKDPEDIASRFARALAASSAAPSYSGTIATIAVPDGIDARQLNALLDGYRKYVDATPAPRIGLAIAAGKIIIKDNLDHVAAAVRSGGIISIGSSSGGARASNGIRKSGKGAAAMSFHSLSINLPRLAYESNKDETYFRAKLALMIKPSLAAMSMRKKTIVDYAKRGLLPSLASATQSMQRGTSTIVINLTGARESVYNILGESSSSEVLQKVLKTATEVAASQGKQLGEEGAGIAMVSDGSGVRFATLDSEKYGKVSLLQSQNTTSYSQGMTLNGKEILSDKGATQECIAIDKLLNGGFAATLDVTDLSAAEAKSAIEVAVAAELPFLRPRIKLAVCTTCGQRSKAVADKCEHCKSPHKLTMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP0</accession>
    <name>K0ILP0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57184">
        <property type="protein sequence ID" value="AFU57184"/>
        <property type="gene ID" value="Ngar_c02360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02360"/>
    <dbReference type="HOGENOM" id="CLU_2784232_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-236-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="68" mass="7971" checksum="78BEF495723E5F4F" modified="2012-11-28" version="1">MPKYFTPNEELVMLFLRKHVNSTAAEITRDTRLKRRGVVRRAQDGLDAKGVLRHTGDTIERYYLVHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILS8</accession>
    <name>K0ILS8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c27310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59652">
        <property type="protein sequence ID" value="AFU59652"/>
        <property type="gene ID" value="Ngar_c27310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27310"/>
    <dbReference type="HOGENOM" id="CLU_1801758_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2731-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="143" mass="15905" checksum="B7BAF575210BE8DA" modified="2012-11-28" version="1">MSSAKGSKLFASDRKSIIIMLTISLFALGVTAGVLLAYQQFTRSAIPNLIAEKDAIQLAIKEGNWDEQSLNDKKIEATLLHVKANGFSFIVDKTALHDTLTLYHSQFPNYEGQYIWIVSITAPNNRDWGYVIDATNGEILMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU8</accession>
    <name>K0ILU8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c04220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57369">
        <property type="protein sequence ID" value="AFU57369"/>
        <property type="gene ID" value="Ngar_c04220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04220"/>
    <dbReference type="HOGENOM" id="CLU_1987689_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-421-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="13539" checksum="30D8832D3BA5EBF4" modified="2012-11-28" version="1">MMRTGEQDRKRSKNASDVTFPAAVFAILIAALVLLLPAISVYAQTVSNEEHADGEQTMTATEQQHEEAGGEHEKADWVGPVIAGAMIATSTITYETLKRRAIREEEKKKGSTAGKEKDKSQHGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM89</accession>
    <name>K0IM89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60102">
        <property type="protein sequence ID" value="AFU60102"/>
        <property type="gene ID" value="Ngar_c31860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31860"/>
    <dbReference type="HOGENOM" id="CLU_2930320_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3186-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6240" checksum="544C7D54A55B75EE" modified="2012-11-28" version="1">MLIILTAVAIIPFAGAVEDYYVSVYTSVASGAGLIVYFAALGMVIIGLVLRIYRSVSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME6</accession>
    <name>K0IME6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57844">
        <property type="protein sequence ID" value="AFU57844"/>
        <property type="gene ID" value="Ngar_c09020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09020"/>
    <dbReference type="HOGENOM" id="CLU_2243942_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-900-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="11750" checksum="0B796AB8FACFD500" modified="2012-11-28" version="1">MRYLTRWIMLLERILQAYATRTGLFRLYNLLLQLGSGFGSIMYNLKGNLRTIGSRCRLAAGVQVFHSLISFVMKKMAQQRKDIGSDTILAMLTGLLSKSKGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMG2</accession>
    <name>K0IMG2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57874">
        <property type="protein sequence ID" value="AFU57874"/>
        <property type="gene ID" value="Ngar_c09320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09320"/>
    <dbReference type="HOGENOM" id="CLU_3194627_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-930-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="45" mass="5287" checksum="AE4F6C31154DDB69" modified="2012-11-28" version="1">MKENLQISRIFNSVRKPVGMIHSMSYELRQLHAVKFKLKEEEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH0</accession>
    <name>K0IMH0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57889">
        <property type="protein sequence ID" value="AFU57889"/>
        <property type="gene ID" value="Ngar_c09470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09470"/>
    <dbReference type="HOGENOM" id="CLU_1292061_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-945-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="213" mass="23852" checksum="42F96AF84877291E" modified="2012-11-28" version="1">MVNYYVFSRIANKYKISMAQQWAIRTYNTYENLSEYSQTKLEHYKTQANKEFSSLIDDISGKLTEVDDKVKWVITFVNPMERLVLHLEQNILPLITSGSENQLADIRPYLLKLTTYFLAPSEELLKELLPSGTSSIESISTSTGLRMIDQNIHGGQKLALPQKHVIIMGLSVLVGIGVYFLAIFIEVDKSSAFLGSVTLAGALIGGYLAYTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH1</accession>
    <name>K0IMH1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC efflux transporter, FtsX-domain permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c33620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33620"/>
    <dbReference type="EnsemblBacteria" id="AFU60277">
        <property type="protein sequence ID" value="AFU60277"/>
        <property type="gene ID" value="Ngar_c33620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33620"/>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OMA" id="DQFRIMD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3362-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="342"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="444" mass="46693" checksum="F5DEB29B4F09AED5" modified="2012-11-28" version="1">MKVTETFRISFKALGDRKVRTSLTILMVIVGSSLMVTLNGIVAGLGQFAMDVFSKLAPNILFITSIPLGGSETEGGDAGGDDGGPPSFLGQGLVSVPAITLDQAVVEKLESLPHVSSVIPSYQGRITVSVENESQSASVLSMQPENLEIIAPALEFVEGSNVSPEDRSAIYLPLSIANKLWGLSEADDGDDNISAAAAAAAKIGRQVEVTYTYIDLATASRQSRSETFTVAGIMEPVGNPTIDRAVVFNLDAGNELLGKSGRYDSLFVAADSTDNVEQVEKEIRNLYGPDIGITTSEAILQTIQEFAAGFGSVISSIALVALLVGSVGIVTTMYTSVTERTREIGVMKAIGARDRNVLALFLAEAAIIGIIGASVGLVVGVLEGYGVLSLFASNLFSSAEVTPRYPLSDLAKVWWISLGLSVAAGLYPAWKASRLSPIVALRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ0</accession>
    <name>K0IMJ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57934">
        <property type="protein sequence ID" value="AFU57934"/>
        <property type="gene ID" value="Ngar_c09920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09920"/>
    <dbReference type="HOGENOM" id="CLU_2230462_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-990-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12211" checksum="1577B1D1BBC15F66" modified="2012-11-28" version="1">MPIRHLVPLLKSHSHNLLGRDWIERRIDDYRILSIMEKGIDDIVGKNSGRLFFHTLRLVYGIDEDKIIQQPELLEEKLQKLFGKSGNAVLQSVGNRLRNEIYEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMJ3</accession>
    <name>K0IMJ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34220"/>
    <dbReference type="EnsemblBacteria" id="AFU60337">
        <property type="protein sequence ID" value="AFU60337"/>
        <property type="gene ID" value="Ngar_c34220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34220"/>
    <dbReference type="HOGENOM" id="CLU_1264598_0_0_2"/>
    <dbReference type="OMA" id="YARYIFT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3423-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="SSF63712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="218" mass="24982" checksum="636EDC8BBE8A33A3" modified="2012-11-28" version="1">MLKYQSLMRSLMMLLLLVSIADITFGRLFTQSFAQGDDDVISSAPTIKQYTIGVYLINVGKIDMQIGSYDLDFYYWLASDDKEVDFVQNPPKVDFMNALNARIEPSRIEPNYYEARVKGTFLKNMDFRNYPFDKQEVTVEIEGFETIENLTFVPDTAASGFDSLVNVPGWTLGTSRSEVIIHDYPDGSYARYIFTFTIERAPLSSFLKTIFPIISTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMK7</accession>
    <name>K0IMK7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10320"/>
    <dbReference type="EnsemblBacteria" id="AFU57974">
        <property type="protein sequence ID" value="AFU57974"/>
        <property type="gene ID" value="Ngar_c10320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10320"/>
    <dbReference type="HOGENOM" id="CLU_583458_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1030-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="433" mass="47561" checksum="5C98EDDEAC43FF98" modified="2012-11-28" version="1">MKSALADTKRSSIKISPSWFDSFYHIDGKMPELTRRVYSLTNPVVDKEVEVKRALAIFRVHTGAGEYAPLLSESLQNFLKVFSTKVSVSCVSAVLTEHPEAQFGMLDYIELHRGDKVGYMPCVTSATQVTDVTRAPDADVHSNIAMTSAIELLNLLGCGMPSSFRLFPVYDAPSEEILDRIRSNLDVFTSRYNLAMEDYSSLKIGKLFYGTTAMASTTKEMPTRYDQIEQGMEIIVTNKFGGLLALNLYTLGRMDSENIIKYEQNEVSFASISEARDEAIKNLSEPHFALGKIITKYCPDFGAPFDKNAHIMAVHPVGSQGVFALGSLAELANSHLLVNELPVRNEEIARFATKEFLVENATASVNGCHLIVAARDVASLVIEDLKKHNFAPERIGVVAKKGAASVAFAKDISQFVASKAKLARLTTSPATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMM1</accession>
    <name>K0IMM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58014">
        <property type="protein sequence ID" value="AFU58014"/>
        <property type="gene ID" value="Ngar_c10720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10720"/>
    <dbReference type="HOGENOM" id="CLU_3094227_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1070-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5626" checksum="FD0340ACA3CA15A3" modified="2012-11-28" version="1">MNVIETELVLPSFALAFLGKGGSDDTTATTREEAKNRIRDTIEEGVKQMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMQ8</accession>
    <name>K0IMQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58109">
        <property type="protein sequence ID" value="AFU58109"/>
        <property type="gene ID" value="Ngar_c11690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11690"/>
    <dbReference type="HOGENOM" id="CLU_2067878_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1167-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="118" mass="13967" checksum="64101C0FD494E202" modified="2012-11-28" version="1">MLLVRILHLLINLQIILLQAVLKNNQQITVHLLVIQRTITIPRLRMVKNRNHRMPLHHLKVSTIILLTRQPRMNNHQKLQVISHHLEMLMLHQAMLLLQPHLLTVQISKVSSNHQLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY8</accession>
    <name>K0IMY8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58449">
        <property type="protein sequence ID" value="AFU58449"/>
        <property type="gene ID" value="Ngar_c15140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15140"/>
    <dbReference type="HOGENOM" id="CLU_119855_0_0_2"/>
    <dbReference type="OMA" id="IASMAWY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1512-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="15890" checksum="B0FA5D937BD3251D" modified="2012-11-28" version="1">MQSATKSRPRGATIAATVSIIGGIAGLFFGIGFIAQDALLHPLIESAIGDLPRQNLSADQASTPGFGIALGTAFLPLAIVSFIAASGLLKGRRWAWTATLVLSIASMAWYAFTVALIPSNGGRMLGVIIGAVTIYFLYRPHVKAYLGKGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN01</accession>
    <name>K0IN01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58514">
        <property type="protein sequence ID" value="AFU58514"/>
        <property type="gene ID" value="Ngar_c15810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15810"/>
    <dbReference type="HOGENOM" id="CLU_2629852_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1579-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8670" checksum="21E68B8DD064E1B0" modified="2012-11-28" version="1">MAHTVRTRRDNLKLLAFMIGAAVFFVVTLFISFFIVIVALNNSDIPGEDKPNMFMLGLIPPSIGTFLLFTKVFGRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN12</accession>
    <name>K0IN12_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58569">
        <property type="protein sequence ID" value="AFU58569"/>
        <property type="gene ID" value="Ngar_c16360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16360"/>
    <dbReference type="HOGENOM" id="CLU_2550379_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1634-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="8439" checksum="28E4D9A9C7475B1F" modified="2012-11-28" version="1">MAICTLALQKCGATLCKTVPHLQKGTCHCPGHPVGFLLVGVAGASNYWLCAGKLGNILMFLKANSALVDATDGLLLLDGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN14</accession>
    <name>K0IN14_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaJ1</name>
        <name evidence="3" type="ordered locus">Ngar_c16460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16460"/>
    <dbReference type="EnsemblBacteria" id="AFU58579">
        <property type="protein sequence ID" value="AFU58579"/>
        <property type="gene ID" value="Ngar_c16460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16460"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1618"/>
    <dbReference type="HOGENOM" id="CLU_1792030_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="16103" checksum="D81C0C54EC79F775" modified="2012-11-28" version="1">MPSYYEILGVSSEATQDEIKKSFRNLALKYHPDKNRNSEESKQKFMSIVEAYEVLSDDQARKIYDNSTLQQRPGPTPRWTPPADFTTVYSYEEIKRRYRPSNIGGGMWDISDKASFGMWKATMVLFACLGAVVIYILLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN54</accession>
    <name>K0IN54_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S30e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps30e</name>
        <name evidence="4" type="ordered locus">Ngar_c18460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18460"/>
    <dbReference type="EnsemblBacteria" id="AFU58779">
        <property type="protein sequence ID" value="AFU58779"/>
        <property type="gene ID" value="Ngar_c18460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18460"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1828"/>
    <dbReference type="HOGENOM" id="CLU_209471_0_0_2"/>
    <dbReference type="OMA" id="RRNIRNY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_S30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6907" checksum="0A6638F517899681" modified="2012-11-28" version="1">MPTHGSLTKAGKVRGQTPKIQGKPRLSPIARMRNKDNFVKRFEKKRLPGQKKPERRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB6</accession>
    <name>K0INB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.1</ecNumber>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gds2</name>
        <name evidence="3" type="ordered locus">Ngar_c21590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21590"/>
    <dbReference type="EnsemblBacteria" id="AFU59089">
        <property type="protein sequence ID" value="AFU59089"/>
        <property type="gene ID" value="Ngar_c21590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2138"/>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="OMA" id="ISYEHRD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="336" mass="36616" checksum="EC5ABFC1E98C5FEC" modified="2012-11-28" version="1">MKASSIKSELESYASTVNEFLLRSLEGKPKELYQASSHLIRTGGKRLRPFMVIKSCEMLGGTVKRALPAAAAVELVHNFTLVHDDIMDNDEMRHGTETVHRYYGLPLAILAGDILFSKSFQLITFNGKKVGIPESDITNMVAQLSRACTEICEGQATDIGFASSTKFPGVQQYIDMIEKKTAALFEVSCALGALSAPSHITRDIENLSSFGRNIGIAFQLVDDLIGVVGDPKLTGKAAGNDIREGKKTYPILLALNSTKGEKRDKILKVFGAKDKASSSDIKEAVRIISDVGIDQDVRNEARKYMNDAIKAIEGYGDSDAKRSLQFSADFVVGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI0</accession>
    <name>K0INI0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59409">
        <property type="protein sequence ID" value="AFU59409"/>
        <property type="gene ID" value="Ngar_c24870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24870"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2485-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="174" mass="20145" checksum="74ADF440847ED6E3" modified="2012-11-28" version="1">MKILIAEDEPDIAMQYELALKDRKHDVIITNDGEQCLEAFYHELEKDEPARNRKMMKRPPFDAVILDYRMPKKDGMEVAKEILAIEPKQRILFASAYVLETLVDSVKTLQQVVELIQKPFELDPFVDLIEDKGIYSELEKLNVNAKEIKDLNPTHQQVLDLLEGLKKLQKGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI7</accession>
    <name>K0INI7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpl21e</name>
        <name evidence="4" type="ordered locus">Ngar_c25210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25210"/>
    <dbReference type="EnsemblBacteria" id="AFU59444">
        <property type="protein sequence ID" value="AFU59444"/>
        <property type="gene ID" value="Ngar_c25210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25210"/>
    <dbReference type="HOGENOM" id="CLU_103610_1_1_2"/>
    <dbReference type="OMA" id="KGMPHRR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12066" checksum="EF2005F803D21496" modified="2012-11-28" version="1">MPRSHGTRRKARSILTKDNVVRGISYLLHDYKVGEKVIVDVDPREHDTTPHRRFHGRIGVVEGVGRRTLRVAVMFGDKKKILQTRFNHIKPLAGAPEMSSAAAGANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL2</accession>
    <name>K0INL2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC uptake transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c26470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26470"/>
    <dbReference type="EnsemblBacteria" id="AFU59569">
        <property type="protein sequence ID" value="AFU59569"/>
        <property type="gene ID" value="Ngar_c26470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26470"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_2"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2647-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="29763" checksum="76C39C00FDA81554" modified="2012-11-28" version="1">MLEKETQSQERRSKGRFDLADVANVALFLAAFVGVWQLVFLLGIWPESSLPSPATVVEAIGNLIANYSLPIGIGVTLLRLVAGFAISIGIGVAVGLAMVKFRGFGKTMSSFAVGLLTFPSIAWVPFAILLIGFNDLGILFVVVMASVFSVMITTYSSIRNIPPIYLRAGRNMGAKGFTLFRHVMIPAATPSLILGIRQAWSFAWHALIGAEILITTLYGLGHVLNVGREFGFMEDVIATMITIFAIGIVFDRVLFAKVEERVRTRWGLDQHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INS4</accession>
    <name>K0INS4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29610"/>
    <dbReference type="EnsemblBacteria" id="AFU59879">
        <property type="protein sequence ID" value="AFU59879"/>
        <property type="gene ID" value="Ngar_c29610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2933"/>
    <dbReference type="HOGENOM" id="CLU_036524_3_0_2"/>
    <dbReference type="OMA" id="GHDWFHI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2961-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="23797" checksum="724610B25F2064BF" modified="2012-11-28" version="1">MLDKIKKRVKKALEGRDPAHDFQHIMRVYKNAEIIGRCEGADLTILLPAALLHDLVVYPKGSAKTSKSADDSADLAEKWLQRYGYPHDKIDKICYCIRTHSYSKRLVPSTLEGKILQDADRLDALGAIGIARTFSVGGTENRAFYNPSDPFWKTKRELNDREWTLDHFQTKLLKLKKSMHTKTAQEIAQERAKFMELFIGQMQKEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU3</accession>
    <name>K0INU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase, CDC48 subfamily</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c30580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30580"/>
    <dbReference type="EnsemblBacteria" id="AFU59974">
        <property type="protein sequence ID" value="AFU59974"/>
        <property type="gene ID" value="Ngar_c30580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3028"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="ENFRFAQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3058-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="214"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="487"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="731" mass="80462" checksum="81705861E08B27AE" modified="2012-11-28" version="1">MSPHGTVSLKVLESYTRDVGRGIARIDYDTMDSLGVRTGDIIEIKGKRRTVAKILPLYPSDEQKGIIRIDGLVRNNAGTAIGDNVTVKKAKTIQAERVTAAPLEPIPPIDERYLTDALEGTSVVKGDNVMIPYFGGRLTFEIGSITPAIGPENAAIVTQKTKFSIVERTQAARGLPQVTYEDIGGLKEEIQKVREMIELPLRHPEIFEKLGIEAPKGVLLYGPPGTGKTLLAKAVANESNAHFISISGPEIMSKFYGESEARLREIFKEARDRAPTIMFIDEIDSIAPKREEVTGEVERRVVSQLLSLMDGLEARGKVVVIAATNRPNAVDPALRRPGRFDREIEIKVPDKFGRLEILQIHTRNMPLESDVNLPKISSVTHGFVGADLEYLCKEAAMKCLRRVLPDLDLEREKIPPEDLEKLIITQGDFEGAIKDVMPSAMREVFLESPDVSWSDIGGLEQVKRELQEAVEWPMKYPELYAKIGHTVPKGILIHGPSGTGKTLLAKAVATESEANFISIKGPELLSKWVGESERGIREVFKRARQASPCVIFFDEIDAIAPIRGGMMGEGGSTSGISDKVVSQILTEMDGISSLHGVVVLAATNRPDMVDPALLRPGRFDRIVFVPNPDRETRRKILQIHSEGKPLAENVDLDRIADITDGFSGADIAAVANAAVSLVLHEYLAKYPTPEEAGKHASEADVTMRHFEEAVKKIRTQKEMKPEEKTSLSLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW2</accession>
    <name>K0INW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative GAF sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31530"/>
    <dbReference type="EnsemblBacteria" id="AFU60069">
        <property type="protein sequence ID" value="AFU60069"/>
        <property type="gene ID" value="Ngar_c31530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31530"/>
    <dbReference type="HOGENOM" id="CLU_1500240_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3153-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="178" mass="20675" checksum="8BD5619BB19452BA" modified="2012-11-28" version="1">MSSEAEEINEVILSCLIENARMSSQEIHKRLKSRGINRTPRAVLERISKLEKEGRIAGYTLKPQPKNFEGFVIRLILISFKTSSVFNERVAMFTSYLQNAPFAAFAGRTRGEYDWINIKIFPNTKIANQESDMYRTVFGDIIEKYTAFDVTVVKAPRFIQATNYSIDNFYEFCQKWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP01</accession>
    <name>K0IP01_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl24e2</name>
        <name evidence="3" type="synonym">rpl24e</name>
        <name evidence="5" type="ordered locus">Ngar_c33490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33490"/>
    <dbReference type="EnsemblBacteria" id="AFU60264">
        <property type="protein sequence ID" value="AFU60264"/>
        <property type="gene ID" value="Ngar_c33490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33490"/>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OMA" id="GTGKMYV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="80" mass="9180" checksum="42B0D73FBFC93175" modified="2012-11-28" version="1">MMRRRTAVDIATTTPTFRNCAFCGRSIPGGTGTMHVRNDGRILWTCSTKCSKNMFVIRRDPRKLKWTEKYVKGGAQVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP08</accession>
    <name>K0IP08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60299">
        <property type="protein sequence ID" value="AFU60299"/>
        <property type="gene ID" value="Ngar_c33840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33840"/>
    <dbReference type="HOGENOM" id="CLU_3075485_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3385-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5668" checksum="05498EF5244C0AE2" modified="2012-11-28" version="1">MAAAECISCGSWTQYGELCIHCRKQRVAIVVEYMVVAGTAANRRAGPVRVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP19</accession>
    <name>K0IP19_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxybutyryl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.120</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c34390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.120" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34390"/>
    <dbReference type="EnsemblBacteria" id="AFU60354">
        <property type="protein sequence ID" value="AFU60354"/>
        <property type="gene ID" value="Ngar_c34390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34390"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3437"/>
    <dbReference type="HOGENOM" id="CLU_023920_1_0_2"/>
    <dbReference type="OMA" id="GWDALNT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3440-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043721">
        <property type="term" value="F:4-hydroxybutanoyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="2">
        <location>
            <begin position="279"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="507" mass="56527" checksum="B54D6D24E5DF14E9" modified="2012-11-28" version="1">MPIKNGAEYIQSLRGRKLKVYLFGELVKEPVDHPMIRPSINAVAETYDLAVEEPELASAKSSLSGIQVNRFLHIAESAQDLVNQNRMQRKLGQLTGTCFQRCVGMDALNSLYSTTFEIDQKHGTQYHKRLIEFIKMVQRENLVIGGAMTDVKGDRSLSPSQQEDPDMFVHITKRDSKGVYITGAKAHQTGCINSHWIIVMPTMRLKAEDKDYAIVGAIPVDAPGITYIYGRQSCDTRSMEGGEIDAGNVMYSGQEAMVIFKDVFIPNELIFMDGEYEFASMLVERFTCYHRRSYVCKTGLGDVLIGAAAAIADYNGVANASHIKDKLVEMTYLNEAIFGAGIASSYMAHKTASGNWQNDDMLANVCKHSVTRFPYEIGRMAQDIAGGLMVTMPSEKEFRSPETGPLLEKYLKGRKGVSTENRMRILRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKKAAKKLANVKEGEAAETAPEQSDYFDKIFGTKDKKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP36</accession>
    <name>K0IP36_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PpiC-type peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35260"/>
    <dbReference type="EnsemblBacteria" id="AFU60439">
        <property type="protein sequence ID" value="AFU60439"/>
        <property type="gene ID" value="Ngar_c35260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35260"/>
    <dbReference type="HOGENOM" id="CLU_090028_6_2_2"/>
    <dbReference type="OMA" id="GPVRTQF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3527-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PpiC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10286" checksum="61DE39F314545AFC" modified="2012-11-28" version="1">MANKIKCSHILVQKQSEAIAILDRLKKGESFSKLAQELSIDRGSGKRGGDLGYFGRGMMVKPFEDAAFKLEKGQLSEPVKTEFGYHIIKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6U7</accession>
    <name>K0I6U7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c00260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56976">
        <property type="protein sequence ID" value="AFU56976"/>
        <property type="gene ID" value="Ngar_c00260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00260"/>
    <dbReference type="HOGENOM" id="CLU_120314_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-26-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU56976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20189" checksum="EE8AC59A3EB245F0" modified="2012-11-28" version="1">MSNVRVNESPNHFMVLDAIARGMKTVDKIAKVTRLSKPEVELIINDLMTQRLIIGTEKKSFFGGKKMEFSISHTGLQLLNTKKLELEKQAQQIQQWYQNGQTQQLQSYMDNNRMWIPMMLFSGIMNAMFFMSMMSLMGMAMSPAESGFAGGEGGAATDGGAAGGAEGDAGGGGDFGGGDFGGGDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8X5</accession>
    <name>K0I8X5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57706">
        <property type="protein sequence ID" value="AFU57706"/>
        <property type="gene ID" value="Ngar_c07640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07640"/>
    <dbReference type="HOGENOM" id="CLU_2032932_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-762-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="13084" checksum="612D764A124366AE" modified="2012-11-28" version="1">MDNGPDVVDNKIVSSSTGRNFFLQAIFFLNGCFFIITEGERRIGAVSVAISTPNSKANVAKVIPSKYDSIFINTVAEKVSSMINGICLVSLHSKSQLQLDDMKAIMGEVMSIVGSKKHEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0I915</accession>
    <name>K0I915_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08340"/>
    <dbReference type="EnsemblBacteria" id="AFU57776">
        <property type="protein sequence ID" value="AFU57776"/>
        <property type="gene ID" value="Ngar_c08340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08340"/>
    <dbReference type="HOGENOM" id="CLU_023082_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-832-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="725" mass="79208" checksum="86DFBA8BC132BB2C" modified="2012-11-28" version="1">MKQHLRLASIALAAILVMATAAATTSVATGSLEKRAQAQHADNEEGISSTTALVRFVTNVEFVRGHLEKAIENKQAGSTELAVAHAGHPIEEVYTLIHQDISVKDSQLASNLKSKLEALPNTVSSDSISTFTQKVTEINGLLDQAVQKVAAGSEAQEEANFTIEIITGLLETANIEYEEAVANGQIIEMIEYQDASAFINRANVLFKTIQTGIDDHEAEEIVEFMDELNFRVASKTDPSQVETVIQGIIRELEEASSAANEHAEFVANLEFIKGHLAQAVANKQAGSTELAVAHAGHPIEEVYALIEPEISEHNSSLNTKLKEALTNLANQIHSLSTSAVQTMVTEINGMLDEAGTSVVSEAERNDPKFNAMVILLLLATAQVEYEEAVENGEIVEMIEYQDSTAFIARSQIISDSIKSKIPAHKAEEIQEFYAELNSLTKSNASFEQVKTVFGGIIHEYEEIFGLEAMEEEEPGEHENSSTTTTKSLGYIENIRKILTKLSEAYRAGNYAEADRLAVDAYLNNFEFVEGDLEKSGNRALMLEIEQLMRIELREMIKGKASVGEIDAHIAKINSKLDQAVNALSPDTIAKTTATRGYHIVRTTITQQSEPHDAEGHSAHQVVYMVYPTEGMIYEGSITFTSTRSVDVFVYHDVTWAEAEDTAGLNIHKVNGRLYAVTTLLKNASSGTVQFAGAGILAHVHSETEGEGEYNLVASMEVYGRLLSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9A9</accession>
    <name>K0I9A9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57921">
        <property type="protein sequence ID" value="AFU57921"/>
        <property type="gene ID" value="Ngar_c09790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09790"/>
    <dbReference type="HOGENOM" id="CLU_2406450_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-977-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10442" checksum="96CD99F1F2BB43C8" modified="2012-11-28" version="1">MGCIARLAKRKPVLFVDDSSESQEAILLFDKSGIEYVKYHIKKFEESCCGELPTTKAPSVFAPDGVFKGMEGVRQYLSEKHDYEKPSESAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9F8</accession>
    <name>K0I9F8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57981">
        <property type="protein sequence ID" value="AFU57981"/>
        <property type="gene ID" value="Ngar_c10390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10390"/>
    <dbReference type="HOGENOM" id="CLU_2406451_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1037-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="11118" checksum="213181B748497CAC" modified="2012-11-28" version="1">MPNDVLLQAHLHANLAFFFPELHLWNRLNQISSIIFDMDFRSQEDQVSQVDARGIYRRYGTRPSEGYVRLRQLTVKDRELRQRFLEEYPHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9G6</accession>
    <name>K0I9G6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57996">
        <property type="protein sequence ID" value="AFU57996"/>
        <property type="gene ID" value="Ngar_c10540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10540"/>
    <dbReference type="HOGENOM" id="CLU_2565855_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1052-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9195" checksum="D8D6E0FFA2729EA5" modified="2012-11-28" version="1">MEVVKASLDRFEGNYAVVYSDDGKKFDVPKDMIGAKAGSRIRLYIEGSKIFRVEVDSKATDEALDKVRKKYGRLKRGDHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9N0</accession>
    <name>K0I9N0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ordered locus">Ngar_c10840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10840"/>
    <dbReference type="EnsemblBacteria" id="AFU58026">
        <property type="protein sequence ID" value="AFU58026"/>
        <property type="gene ID" value="Ngar_c10840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10840"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1027"/>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_2"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="467" mass="52519" checksum="3CD81C0C6A7A3090" modified="2012-11-28" version="1">MTAKEDLNMDYSKYDFKDSTELYIYLSKKGLSRGTVEEISRLKGEPDWMRDFRLRSYEVFMSKPMPNWGGDLSKIDFQNIYYYAKASEKSSKSWEDVPESVRNTFEKLGIPEAERKFLAGVGAQYESEVVYHNLREDLQKQGVIFVDTDTAVKEYPEIVKKHFGKVIPPEDNKFAALNSAVWSGGSFIYVPPNVKVELPLQAYFRINAENIGQFERTLIIADEGAEVHYIEGCTAPVYTTESLHSAVVELIAKKGAKIRYTTIQNWSKDVYNLVTKRAYAYENARVEWIDGNLGSKLTMKYPGVYMLGKGAHAEVVSVAFAGKDQHQDAGAKAVHLAPNTTSRITSKSVSKDSGRTTYRGLLHVAKGATAVKSNVRCDALLLDEHSRTDTYPYIEVNEDDATITHEATVGKIGEDQIFYLMTRGYSESDALSMIVGGFMEPFTKELPMEYAVELNRLVKLEMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAP2</accession>
    <name>K0IAP2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58401">
        <property type="protein sequence ID" value="AFU58401"/>
        <property type="gene ID" value="Ngar_c14650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1429"/>
    <dbReference type="HOGENOM" id="CLU_1727301_0_0_2"/>
    <dbReference type="OMA" id="KWRQVRR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1463-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="17005" checksum="E2186F6F5D5E64C8" modified="2012-11-28" version="1">MVQIETTASLESFRKFIIVSTCRSFIPESYLRDYEVFPEREEGPGAIYIEAADKVTLKKIREMTFVNAKEILGIIYSSKSGNTQLKWRQVRRRGGKVQGFASPNALVNLVESGVLTQEWVDNYLKSVQNQERGSEDSSSPSSSVTESEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAV3</accession>
    <name>K0IAV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal recognition particle 19 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp19</name>
        <name evidence="5" type="ordered locus">Ngar_c15270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15270"/>
    <dbReference type="EnsemblBacteria" id="AFU58461">
        <property type="protein sequence ID" value="AFU58461"/>
        <property type="gene ID" value="Ngar_c15270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15270"/>
    <dbReference type="HOGENOM" id="CLU_169299_1_0_2"/>
    <dbReference type="OMA" id="WLDYFNK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="12292" checksum="92C7F34EA7DA8C10" modified="2012-11-28" version="1">MKDYDHVVLWLDYFNKNLKRRQGRKVNREQAVFDPTVQELAEAAKAAGFQFSDQEVNDNARFPRRSFTRSGYVMVAKKEGVKKSQVIDAVAEKIVQRRSKQKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IB98</accession>
    <name>K0IB98_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S26e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps26e</name>
        <name evidence="4" type="ordered locus">Ngar_c16530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16530"/>
    <dbReference type="EnsemblBacteria" id="AFU58586">
        <property type="protein sequence ID" value="AFU58586"/>
        <property type="gene ID" value="Ngar_c16530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16530"/>
    <dbReference type="HOGENOM" id="CLU_129451_3_0_2"/>
    <dbReference type="OMA" id="DKAICVT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_S26e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_S26e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="PTHR12538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="95" mass="10159" checksum="3784264BEF73097D" modified="2012-11-28" version="1">MPKKRASRGRSKGGKGSSGVVHCSSCGALVPRDKAKKVTGRITLVEPTLAKELRAAGAYIPMSTDVKFYCVSCAVHRGVVKVRSESDRRTAGKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBM7</accession>
    <name>K0IBM7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56970">
        <property type="protein sequence ID" value="AFU56970"/>
        <property type="gene ID" value="Ngar_c00200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00200"/>
    <dbReference type="HOGENOM" id="CLU_2968560_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-20-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6634" checksum="4E8B929528BB26C0" modified="2012-11-28" version="1">MYMFESKVYECQACGQFFFFKQDADDHTSKTGHASFKVTDWTSPAQPSPRINRGKAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBW4</accession>
    <name>K0IBW4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Ngar_c00900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57040">
        <property type="protein sequence ID" value="AFU57040"/>
        <property type="gene ID" value="Ngar_c00900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00900"/>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="OMA" id="SEYIMSA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-90-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="181"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="292"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU57040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="398" mass="46946" checksum="487C0C321CB5DB9E" modified="2012-11-28" version="1">MKNMLLYYHNQSIIMTLNYKFRLYPTKEQELLLEQTLDGCRWVYNYFLSLPSPMSEYDMNYALTELKEQHPWLRKYYHSKMLQMVAKQVAAARKVAKGRKLSYRKDSDFNSFTYNQSGFRLENNNRLSLSKIGRIRIVLHRQPVNVKQVTISRTKTGNKWYAIVACDVLRRSFSTIIRYAKPVGIDVGIAKFCHHSDNHVEDNPQFLTKMLRPLRRAHRRVSRRQIGSNNRKKAKRMLARLYERINNKRKDFLHKKSAYYASRYDLIFLERLRVMNMTKNHRLARKILDASWSAFKNMLQYKANRVVEVEPSYTSINCSRCGHPVPKSLAVRIHVCTKCGAILDRDYNSAINILKRGLESLVLLLLPVERREVTPVEIVLQQRSLKQEEKEEAIGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICK4</accession>
    <name>K0ICK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphohydrolase, DHH superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c03980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03980"/>
    <dbReference type="EnsemblBacteria" id="AFU57345">
        <property type="protein sequence ID" value="AFU57345"/>
        <property type="gene ID" value="Ngar_c03980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03980"/>
    <dbReference type="HOGENOM" id="CLU_076809_0_0_2"/>
    <dbReference type="OMA" id="IYSATHY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-397-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="321" mass="36014" checksum="35F46D97790BD5AB" modified="2012-11-28" version="1">MQIMKVMIFSHESDLDGLYSAAIGLLRYPQAMTIFLGYGVENFQKLGNFIYSATHYSPERGLIIISDLGLNDDLIETCRQIFSDAVRNGWKIMWIDHHHWSQQAIDAVKPLVEVVLDTSGTKCASDLMYETFLPGSELAARLAGMAHTMDFFTKDQYLTPISELIRYYQTFPNFYDRLSELARKSAKGILWDVEMQSDYNDYARLRDEARIQVFATIQVRPVGRFKVAYVQSSPYLQNSLFSEEVFAKTNADLIMFYSTKGKVSIRRSNDAISCRDVAANLHEGGGHAYAAGATFKSDPSDVSAVISELEAAVAKAVASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICQ0</accession>
    <name>K0ICQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57415">
        <property type="protein sequence ID" value="AFU57415"/>
        <property type="gene ID" value="Ngar_c04710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04710"/>
    <dbReference type="HOGENOM" id="CLU_2597856_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-469-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8777" checksum="A6A12F8C7A21E19F" modified="2012-11-28" version="1">MYKSFDADRELSKDALTLLCRPSDFSVPDEVMISLESDYSKPKSLRDPPAAMADVPIVAANTLEKGEQCMIHPLTFQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICV2</accession>
    <name>K0ICV2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22510"/>
    <dbReference type="EnsemblBacteria" id="AFU59181">
        <property type="protein sequence ID" value="AFU59181"/>
        <property type="gene ID" value="Ngar_c22510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22510"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2249-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11176" checksum="A400DCFADE17032B" modified="2012-11-28" version="1">MSLQRTGFRVHSFTDPLEAINHIAKDGCKDCELLVPDIRMLGMDGFELVRRVKMLRPEMNVVMMMAFEVNKREFEQVFPSTPVENVLSKPFVPHLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0ID17</accession>
    <name>K0ID17_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein Ngar_c23450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23450"/>
    <dbReference type="EnsemblBacteria" id="AFU59271">
        <property type="protein sequence ID" value="AFU59271"/>
        <property type="gene ID" value="Ngar_c23450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23450"/>
    <dbReference type="HOGENOM" id="CLU_095956_0_0_2"/>
    <dbReference type="OMA" id="LRLAHMI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2343-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="21831" checksum="7C76C2B83BB9187D" modified="2012-11-28" version="1">MRPPAHRVHPEKKGIRVLGIAESFKKSGEKSTLAGVVMRRDLIIDGMAFGSATIEGDDATDSIISMHRSLERDDINCMLLDGLVISMYNIIDGERVATETGLPIIAITFEDSDGLEGSIKHHFDDDKWQSKLEQYRKLGRRERIMLKTGKSLFIRYWGLSQKRAVAILNSFTLQGSVPEPIKVAKLAARSHANALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDA6</accession>
    <name>K0IDA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57645">
        <property type="protein sequence ID" value="AFU57645"/>
        <property type="gene ID" value="Ngar_c07020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07020"/>
    <dbReference type="HOGENOM" id="CLU_2802392_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-700-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7333" checksum="F4235DA9D85B21B4" modified="2012-11-28" version="1">MVVEKMKAKTFIAITILAGAIASTILATINIVVIEPYIDRAIEIENQNAAAAGEMINPIEFLNYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDD7</accession>
    <name>K0IDD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24840"/>
    <dbReference type="EnsemblBacteria" id="AFU59406">
        <property type="protein sequence ID" value="AFU59406"/>
        <property type="gene ID" value="Ngar_c24840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24840"/>
    <dbReference type="HOGENOM" id="CLU_1003322_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2482-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="270" mass="28887" checksum="E7E9718042C1F8AE" modified="2012-11-28" version="1">MEEQQAYLDIKRARRNLVLGLIAAIAAIDGAVFFTAGSEIEAIVSDISRVGTVCAAAALSLVVVRRQKVGGLFGRAYAALAAGLMLWVVAESIWAYYELGLGIGAHTTSIADVFWISGYGPFAYHLLSTARFFGKGLKRSAIAIVGVAAALFLAFYIQTLVGVFELEGPGALATLAISIVYPVLDALLIVPAVLIVMNAGKGQLTSIPWIFIGWILLVLADSMLGVAAASDMSEVFHITMAYNAAYLCFAAGLLWYNRQFIISDKKLVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDF9</accession>
    <name>K0IDF9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59436">
        <property type="protein sequence ID" value="AFU59436"/>
        <property type="gene ID" value="Ngar_c25130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25130"/>
    <dbReference type="HOGENOM" id="CLU_2379508_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2512-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="94" mass="9892" checksum="CF2F51FAD59DBB16" modified="2012-11-28" version="1">MQFLCALKVTSKNANATVMGYQICLSSACASSEGLRHEASGTVVGQNNTPPKEREWSNAILLGSIEGWKVGDTADIKIQVNLLPIVMAAADGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDN5</accession>
    <name>K0IDN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59506">
        <property type="protein sequence ID" value="AFU59506"/>
        <property type="gene ID" value="Ngar_c25840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25840"/>
    <dbReference type="HOGENOM" id="CLU_3130974_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2584-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="49" mass="5520" checksum="7C52F72624CA8C97" modified="2012-11-28" version="1">MAATYRPKTFTCKKDGKQFDSLADLQKHITIEHLQKGEVTSPDAITKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDS2</accession>
    <name>K0IDS2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59536">
        <property type="protein sequence ID" value="AFU59536"/>
        <property type="gene ID" value="Ngar_c26140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26140"/>
    <dbReference type="HOGENOM" id="CLU_1665401_0_0_2"/>
    <dbReference type="OMA" id="CRIDERV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2614-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17579" checksum="C52F5AA7C09AFD7F" modified="2012-11-28" version="1">MDDLRHNIESNRDALAAALKRSPNMAYQKVNELALFVGFRHGVDLQLHFPEPAKISDIGSYGTENVGIVVDKFRKTFPVPREAVKQKAVELLGSDARPQDAYMYEGKEGVKVIMPEGRIEILPGSVHFWCRIDERVRSYADWLVENVYFPNKTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDU2</accession>
    <name>K0IDU2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56983">
        <property type="protein sequence ID" value="AFU56983"/>
        <property type="gene ID" value="Ngar_c00330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00330"/>
    <dbReference type="HOGENOM" id="CLU_210694_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-33-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU56983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6682" checksum="6D749B3B7E2A0703" modified="2012-11-28" version="1">MNFRNAIQTRVGSGAPKNEQERTVTDRDGVAHLEYFMNGSWRHSTARCKLRVNKTCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDX2</accession>
    <name>K0IDX2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flaB</name>
        <name evidence="6" type="ordered locus">Ngar_c10080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10080"/>
    <dbReference type="EnsemblBacteria" id="AFU57950">
        <property type="protein sequence ID" value="AFU57950"/>
        <property type="gene ID" value="Ngar_c10080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10080"/>
    <dbReference type="HOGENOM" id="CLU_084671_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="PTHR35903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="228" mass="24070" checksum="2D859CFA9663F020" modified="2012-11-28" version="1">MNHKGKFRRSRRGVIGIESAIVLIAFVIVAAALSFVVLNMGFSTTQKAKQTIGQGLDTSSSVLEVGGSVSGHLNSTAGALDIVTIPLKVASGSKSVDLQESLTAVRYFTRTLNYDNIYNGTLSSTTYGSVSDALAAAKTAGILDKNPLASSGAANPTKTVAIIYWTVNENNNDVLDKSESATLAIVFRNADMPKQLDRINAEVIPSIGAPMTVARDVPTLTDTYQDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE26</accession>
    <name>K0IE26_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="3">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">garR</name>
        <name evidence="3" type="ordered locus">Ngar_c10780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.60" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10780"/>
    <dbReference type="EnsemblBacteria" id="AFU58020">
        <property type="protein sequence ID" value="AFU58020"/>
        <property type="gene ID" value="Ngar_c10780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10780"/>
    <dbReference type="HOGENOM" id="CLU_035117_0_6_2"/>
    <dbReference type="OMA" id="WSSEVNN"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="2">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="292" mass="30863" checksum="92C6D6360C599E20" modified="2012-11-28" version="1">MMKVGVVGLGLMGSGIATRLASTGHLMSVYNRSSEKARRFSKSASIASSPKELADNCDLVITVVTDFDAVKDVLLGKGGVIESTNRDLIVADASTISPMQSEHCARELRRAGIEMLGMPVMGGPAAAEAGDLVPMVAGRRQAFEKAKTVIEKLGKTFYIGERDGSANAIKLALNLNIALIASAVSEGITLAKGSGIDPAIFVQILNSTYFKTGLSEKKGPKMVKNDFTPSFHLKNMLKDLELATGTAQAAGITLPQTALAQQIFRAANNSGFSEQDYTSICAFLAKINGMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE34</accession>
    <name>K0IE34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system FeS cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nifU</name>
        <name evidence="2" type="ordered locus">Ngar_c10880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10880"/>
    <dbReference type="EnsemblBacteria" id="AFU58030">
        <property type="protein sequence ID" value="AFU58030"/>
        <property type="gene ID" value="Ngar_c10880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1031"/>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_2"/>
    <dbReference type="OMA" id="YKNPRNY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="15754" checksum="22EFC3BAC21B4E6B" modified="2012-11-28" version="1">MSDDIYREIILDHYRNPRNKGKLPDADVSIHDSNPLCGDEIDIHLKVDGDRIKDIRFEGRGCAISQASASMLTEMVQGKPLTSVKDLSKDDILENIGLMNLGPARIKCALLSLKVLKLGMVKYYADRDPASAKKLQEDSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IED0</accession>
    <name>K0IED0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC uptake transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c27600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27600"/>
    <dbReference type="EnsemblBacteria" id="AFU59681">
        <property type="protein sequence ID" value="AFU59681"/>
        <property type="gene ID" value="Ngar_c27600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27600"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="GHDHVHP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2760-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="247" mass="27870" checksum="39ED0645E28F7126" modified="2012-11-28" version="1">MPIIDAVKVDRVSYDYGQGKILDDISFSVEEGDLLGMIGPNGAGKTTLFNCMLGLIEDYDGRIEIFGEDIRKSRKVLQQIGYVPQKKSIEQGFPATVEDIVSLGATRKPSKGNISQAIETVGLLDFKDRRIGELSGGQQQRVFIAKALVNEPRLMILDEPATGIDQETQNKFYSLVKKLNKENHITIIWSSHDLEAINSIANKVACINRSMFFHGKSHEFFDNPELLRKYSESSMQAHMHDHYHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEE8</accession>
    <name>K0IEE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative modification methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c27850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27850"/>
    <dbReference type="REBASE" id="55352">
        <property type="entry name" value="M.Nga92ORF27850P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59706">
        <property type="protein sequence ID" value="AFU59706"/>
        <property type="gene ID" value="Ngar_c27850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27850"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2757"/>
    <dbReference type="HOGENOM" id="CLU_027633_1_0_2"/>
    <dbReference type="OMA" id="SHTTVAY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2785-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="427" mass="49055" checksum="78218886A75B2795" modified="2012-11-28" version="1">MQSTFEGPERKREIKDDWTFADADTRRMTHGLHTYPARMIPQVTEKLITKFAKSESDDLCIDPFCGSGTVLVEAKLKGIKSVGVDANPLAVLISKVKTTPIKKEVLEREWSSLRQKIEGDISKEKPVEVPTIKNLEYWFKPQAINGLAIIKHHINKIENKDVQDFFKVCFSVTVRKVSNIRSGEFKLYRLPPDKLKLHDPKPLLAFSEVTNNNIQRMDKFYKAVDKSVKSIVVKGDTRKLLELDPRNLYENCATLLITSPPYGDSHTTVAYGQFSRYSSAWLDFDEEEVWKVDRIALGGKLFDEVEDLESPALTHTLHMIADADEYRARETYAFFKDIDTCFAQIAKVMKKRKSTICFVLGNRTVKRMVVPADQIMIELGHKHGFKYYDTYHREIPNKTMPLQNAPENEIALKGETISKENIVVWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF00</accession>
    <name>K0IF00_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Ngar_c14140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="55356">
        <property type="entry name" value="M.Nga92ORF14140P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58350">
        <property type="protein sequence ID" value="AFU58350"/>
        <property type="gene ID" value="Ngar_c14140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14140"/>
    <dbReference type="HOGENOM" id="CLU_024927_2_2_2"/>
    <dbReference type="OMA" id="LWNFSGE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1412-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="9">
        <location>
            <begin position="104"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="326" mass="36230" checksum="D8ADBECD61D7E4A5" modified="2012-11-28" version="1">MSLAHGAREKPRIKSGRLVLKIIILAPDCGIMAGRRKTTETSDFGVSRREGHDSSKFYSRKLYDNNGKDGTSSSGVENAVPPEYVDKVLCKSSEKMTELPDSCVHLAVTSPPYNVGKTYDQDLTLAEYRQLLKTVFSEVFRVLVTGGRVCVNVANLGRKPYIPLHSYVIADMLDIGFLMRGEIIWNKGSSAGASTAWGSWQSAANPALRDTHEYILVFSKGSFSRAAMGRYNTISKEEFLSYTKSVWEFPAESANKVGHPAPFPIELPYRCIQLYTFWGDFVLDPFCGVGSTCVAAIRTGRHFLGYETKQEYVGSALRRISKEDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF19</accession>
    <name>K0IF19_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="9">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rtcB</name>
        <name evidence="10" type="ordered locus">Ngar_c04520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04520"/>
    <dbReference type="EnsemblBacteria" id="AFU57398">
        <property type="protein sequence ID" value="AFU57398"/>
        <property type="gene ID" value="Ngar_c04520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04520"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.435"/>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_2"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="6">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="491" mass="53039" checksum="63297B0D38A892D1" modified="2012-11-28" version="1">MSELVTRSGNHRVRKVSDLEYRIDPNPDRGMKVPVTIYANDLLISKMVTDRTIDQAANVATLPGVKKHVVVLPDGHEGYGFPVGGVAATDIEEGVISPGGVGYDINCGVRLVRTNLTESDLRPRLKDLVNELFKSIPSGVGSEGAVRLTKAELDELLVEGVRWAVRHGYGTEDDAEVCEESGMMAGADPASVSDTARKRGAPQLGSLGSGNHFLEVQKVDKIFDERAAKAMGLDQVGQLTVLIHCGSRGFGHQICTDYLRVSESALRKYGLTLADRELACVPNNSKEGEDYRKAMYSALNFAWANRQMITHWTRKTFERVFKAGEGGLDMDLVYDVAHNIAKVERYKVDGEGTRDVVVHRKGATRAFPAGMEQVPGKYRGIGQPVIIPGSMGTASWILLGNKKSLDLSFGSTAHGAGRTMSRSAAKRSYTAEGVKSGLESKGIYVKALTREGVVEETPDAYKDVDAVANVSHSLGIATKVVRLVPIGVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFE1</accession>
    <name>K0IFE1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urea active transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c06050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06050"/>
    <dbReference type="EnsemblBacteria" id="AFU57548">
        <property type="protein sequence ID" value="AFU57548"/>
        <property type="gene ID" value="Ngar_c06050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06050"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.578"/>
    <dbReference type="HOGENOM" id="CLU_010778_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-603-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="entry name" value="PTHR46154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="8">
        <location>
            <begin position="649"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="788" mass="84325" checksum="C55624076C77002B" modified="2012-11-28" version="1">MVVLSEGVGYFILLGVGLVMALAVTSLVRAETKWLGTRKTFEWFSTAGRTVKTGLIASSVVSAWTWAATLLQSSTVAYQFGISGPFWYAAGASIQVVLFAILALEVKRKAPSSHTFPEIIFARFGKNSHKVFLFFALMTNTIVTAMLVLGGAAVVNSLTGVDIYIAAFLIPVGVIIYTFFGGLKATFLAEYLNSVFLFAVVLVFISVIYFSNPQVGGISGMFDRLTEAAAIKPVDGNFAGSYLTMASTGALIFGIINIVGNFGTVFVDQAYWQRAIAAAPKSAFKGFLIGGLAWFAIPFALATALGLAAVAIHAPLMPEQISMGLVAPTAASQILGDVGAILLLTMLFTAVMSAGSAELVSVSSLITYDVYRTYIRPSATGRSLMRISRLSILFFGMGMGSLALVLLQVGASLQYVYLAMGVLIGSAVVPIALAVVWKKTNKVAATVGALIGLCCGLVVWLLTAYTLYGAISVHSTGQNIPLLAGNLTSILVGGAITLLGSVIKPENFDFRVMKQKILIVDAKIRRLVEDENDEEYLLRSSRFGYKVAVALTLVLVVAWPMPLYLSGYIFSQTVYSIWIGVAVLWAGAAAAAIILLPLIESRKGIVKVLQRIGYHVIDTRPGYRLSADDDRSDNNHYGDTGINRSAAYNRKILVPLDGSLQSLRALNSSTNLLANAGSVTATTTVYILNVIEWMDENDESVDDELAAIMEEQGKKMLRSILLPKSRSSVKYERIVKLGDPATKIIETAEKLGVDLIAMGTTGLGDAKEIGHVSSKVLRLASMPVVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFF0</accession>
    <name>K0IFF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57558">
        <property type="protein sequence ID" value="AFU57558"/>
        <property type="gene ID" value="Ngar_c06150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06150"/>
    <dbReference type="HOGENOM" id="CLU_1933332_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-613-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="138" mass="15431" checksum="549CEBF72432018D" modified="2012-11-28" version="1">MSGKEMLIRHCVEENNVDEEMNVIDATKVRHVTVKAGKIESMSGLVDPASHLNLDYPDHRVTICVIAEQFAVGAKVRMDDDGLLFATVQRSSYGHYGKVDYTQRLVELISAVKKNQQSTRSAAASQQEQQQQQQVTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFG6</accession>
    <name>K0IFG6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-dehydroquinate synthase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
            <ecNumber evidence="3">4.2.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroB</name>
        <name evidence="3" type="ordered locus">Ngar_c16220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EC" id="4.2.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16220"/>
    <dbReference type="EnsemblBacteria" id="AFU58555">
        <property type="protein sequence ID" value="AFU58555"/>
        <property type="gene ID" value="Ngar_c16220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1591"/>
    <dbReference type="HOGENOM" id="CLU_056379_0_0_2"/>
    <dbReference type="OMA" id="HFGMAIK"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="332" mass="36335" checksum="563D0002AAD807F2" modified="2012-11-28" version="1">MSKLKEKGITIINADPKVAGKDFHTIYESEDADMVICKTFDQLKSLRSSSGKSLGYFKKVLSNADVDEIERASQAGAEFVIVDASDWKIIPLENIIAKLHKSKTKVFTTAKSSREVATMFAVLELGVDGVILSTDSEDEVDKARQQLSTARFPIKPAKIVEIKDVGTGERVCVDTASMMGMGEGMLVGSRSNFMLLVHNESVGSSFTSPRPFRVNAGAVYCYTIAPDGKTRYLSEIESGSEVWVVNKEGSARRAVVGRSKIETRPLRLIRAEIEGETGTVILQNAETIRLITKDGKLLSVTEIKVGDEVLGYAKPASGRHFGMEVDEYIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFX2</accession>
    <name>K0IFX2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">K+ transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c33760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60291">
        <property type="protein sequence ID" value="AFU60291"/>
        <property type="gene ID" value="Ngar_c33760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3369"/>
    <dbReference type="HOGENOM" id="CLU_1297524_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3377-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="23970" checksum="C883A2F096292DC0" modified="2012-11-28" version="1">MAGLSFTGFFLMAYGEKGQMNLRQASIFIVTSFVVMSLFGSLPYIYLTRLGRTLMAICSVNSLFESASGFTTTGLSMITQPENLPQSFNFYRAYTQWVDGLSFIYLVMIFFPEEKLSAWKSVLGGGMLQFKEFLVTLVCIFSVYTVVLVFLLLLTGQIADIYAVSAVFATITGGGFFAYLRFYFAGQHWFPRSHQRRHDTLRAPLRLPLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG40</accession>
    <name>K0IG40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57778">
        <property type="protein sequence ID" value="AFU57778"/>
        <property type="gene ID" value="Ngar_c08360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08360"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.798"/>
    <dbReference type="HOGENOM" id="CLU_1159087_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-834-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="239" mass="26645" checksum="CD65EAA845C0B358" modified="2012-11-28" version="1">MATVLLGTAVVLHLINHEVFHHNAAYAQDTTTVLADTEALIVIVNIERIRTQLELTEKSLNTDDLEMAFAHAFIPHTTTFPAIKSQLRAIDEQPATQLEAMLTDLPIKIRTAGKDSEGEARDDIKQIQTLLDKISQKAIGSQLMSDKGMVSKTVVFLLRDAAQSYQVSNAAAGGQEQFSQVDYENAISITARAESTYQIIAPEIDKRRRGEIDSFIAELLTAFDQKSDIMNQYRVWLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG43</accession>
    <name>K0IG43_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34610"/>
    <dbReference type="EnsemblBacteria" id="AFU60376">
        <property type="protein sequence ID" value="AFU60376"/>
        <property type="gene ID" value="Ngar_c34610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34610"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3460"/>
    <dbReference type="HOGENOM" id="CLU_096980_1_2_2"/>
    <dbReference type="OMA" id="WPGGWAA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3462-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="16065" checksum="DCC7D81E367344B1" modified="2012-11-28" version="1">MTMMKSKTEYLTFNTSTRRAFINITPQVAKIVAESGVKEGLCLVNAMHISASVFINDDESGLHQDFDRWLEKLAPYSPDSYLHNRTGEDNADAHLKRQVMGREVVVAITNGRLDFGPWEQIFYGEFDGRRQKRVLVKVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGA5</accession>
    <name>K0IGA5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57853">
        <property type="protein sequence ID" value="AFU57853"/>
        <property type="gene ID" value="Ngar_c09110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09110"/>
    <dbReference type="HOGENOM" id="CLU_1976602_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-909-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="126" mass="13643" checksum="902DC603D1C6DA92" modified="2012-11-28" version="1">MNFFSHSWHRLVAPSALAVVYMNIASGIFLPGVAHAFVYKPMFLLQLVVRPPYSSVYTHRQTDRESRAIADAAPQTTSTKGCCTGTSKTVIPPPLPHGCMLSSAVPFQKSPPSPPWLEPAFSGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGA9</accession>
    <name>K0IGA9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58830">
        <property type="protein sequence ID" value="AFU58830"/>
        <property type="gene ID" value="Ngar_c18980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18980"/>
    <dbReference type="HOGENOM" id="CLU_2550393_0_0_2"/>
    <dbReference type="OMA" id="KPELMET"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1896-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="82" mass="9269" checksum="F643BA7E05D9823D" modified="2012-11-28" version="1">MAAGGDDYPVVAGQDGIKLKTEKMVTDQLYYCIYDNKVFLFYKDEEGLLHCYEVENPDAVREIAQNPSEIESILKRYAAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN9</accession>
    <name>K0IGN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC uptake transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c00270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00270"/>
    <dbReference type="EnsemblBacteria" id="AFU56977">
        <property type="protein sequence ID" value="AFU56977"/>
        <property type="gene ID" value="Ngar_c00270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00270"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.29"/>
    <dbReference type="HOGENOM" id="CLU_028808_5_2_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-27-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU56977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="14937" checksum="E1193AE4A5E0DB4F" modified="2012-11-28" version="1">MAGAILAIVILLYRQFMYVAFDEEQAKVSGLSITNLSYLFAVLASVSVIVSMRLVGILLVSSLIVIPNITALLLGKGFKKTALISVGISIFSVVTGIIVSYAANFPPSATIVIVLIAVFLATLAAKYSSKKKKQIVEAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGP8</accession>
    <name>K0IGP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56987">
        <property type="protein sequence ID" value="AFU56987"/>
        <property type="gene ID" value="Ngar_c00370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00370"/>
    <dbReference type="HOGENOM" id="CLU_2968563_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-37-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6720" checksum="CD771D2E88BE6FC5" modified="2012-11-28" version="1">MKSLIALKPFAHSPKDKKPKYCSTCGSLATLEAHFDVGDSVTMIEKYCDAYSKKITTYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH45</accession>
    <name>K0IH45_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like/flavin-/F420 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12080"/>
    <dbReference type="EnsemblBacteria" id="AFU58148">
        <property type="protein sequence ID" value="AFU58148"/>
        <property type="gene ID" value="Ngar_c12080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12080"/>
    <dbReference type="HOGENOM" id="CLU_1640019_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1206-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="161" mass="18283" checksum="07297D5839815074" modified="2012-11-28" version="1">MDRHGIKRCWPSDHYMPWWHTGAAGGAAWPWLGAALAKTNKIAIGTGVTAPILRYNPAIVAQVFATLGYMFPCRVFFGLGTGESLNEVPAGSAWLSNHERLERLEEAIKLLWVEEWVTFQGKYYQVKDQTSTQNWRSQSRYTSLALARRPQGWTVRKQMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH97</accession>
    <name>K0IH97_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57162">
        <property type="protein sequence ID" value="AFU57162"/>
        <property type="gene ID" value="Ngar_c02140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02140"/>
    <dbReference type="HOGENOM" id="CLU_3094222_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-214-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5729" checksum="42C10DBE8A57CC5D" modified="2012-11-28" version="1">MTDNIILSFNLTNQVDAIGLNLASDNVFKIEAIRARIESFDRALEANVFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHG1</accession>
    <name>K0IHG1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Copper resistance family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Ngar_c02840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02840"/>
    <dbReference type="EnsemblBacteria" id="AFU57232">
        <property type="protein sequence ID" value="AFU57232"/>
        <property type="gene ID" value="Ngar_c02840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02840"/>
    <dbReference type="HOGENOM" id="CLU_302009_0_0_2"/>
    <dbReference type="OMA" id="NVWFVEQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-284-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="10">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="11">
        <location>
            <begin position="333"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="12">
        <location>
            <begin position="652"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU57232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="973" mass="103044" checksum="A92193861BC88122" modified="2012-11-28" version="1">MMLASGILQQQSFAHPVTTDSSPKAFEGVRSPPREVNVFFSEPIELSYSKISVIGPDGSRVDNNDPHHVDGDTASIGVTLKPDLPDGEYTVSTSVLSAIDGHVVPGTFVFGIGTMPQQGGGQVGEQQQDVLAPGYSASRFPGMVGQVMVVGAAFGALWLWKPLARVPWLSSTLSQTRVSIDRSMMRIMIIGVALVLVSGAAMIVVQAISIGSGIPEAILTKFGNVWVARMLQSSILMGIVFAVYRKAAKNSSSPSRAEMYAILILGLAVMATSSLIAHAAATNQIHSIILDFFHNAAASIWIGGLILLGFAAVPKILAIADERVKATALSLLIPRFSTVVATLLGIAVITGPVLLFTLESDLSLTIASVYGQILAVKLGLAGVMVGMGAYSQFVIQKRAVAVMVGGRGRSSVQDTGLRRYGRTLKAEAAVGIALLLAVSFMANGSLPAGQFPAYARQQQAADGSQAAFAKESKVDFVRTLYTDNGKIQLAITPFAVGQNSFKISFLNQDGSSATGIESATIKLTQVDRGIGPIPIETRKQAGSNNVFLADAAFSLPGNWQIEIEGVNTQGGNMLASLDANVKPQVSNLQFKVDQYKTPENSLPLYPVFDAARQSIWVGDSIPGSGRIWQMDITTGNYTVHNIDGAVLVTNVLLAPDGRIWYIDPLGGGSSDGSNRGALGVYNPEDNSNRRFIMPEAGTPSGIAIDGSGNLWITVGGLANKIAKFDPVNEEFSLYDVPTQEADPRGIVVDNSGNIWFAEATAGRIAKVDHATGNITEYAPNSKLQTLDEPTALFPDPEGFDIYIAEHGGHTITVFNSLLGTFREYPSVNEEGLPFGMAMDSYGNLWFAEHTIDRVGVIDPRTGEGTEARIPITGSQIQWITADNDGRIWFAAQRGSALGSITITARPSTAPPGSGEQNGSTTTGGIIPQLPFSFTDVVGPAIAAGIVISALAYTKSAIDLKRNTQSALRLEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHI6</accession>
    <name>K0IHI6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cob(II)yrinic acid a,c-diamide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24770"/>
    <dbReference type="EnsemblBacteria" id="AFU59400">
        <property type="protein sequence ID" value="AFU59400"/>
        <property type="gene ID" value="Ngar_c24770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24770"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2452"/>
    <dbReference type="HOGENOM" id="CLU_070764_3_1_2"/>
    <dbReference type="OMA" id="FMQPWDF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2475-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02145">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="250" mass="27948" checksum="4E01319106A94F88" modified="2012-11-28" version="1">MTAADSSNGSSLTGSEKEGLYKAIFSRRDVRSHFVDREIPDDVLLRILNAAHHAPSVGFSQPWNFILIKDRAIRQKVKESFLRERSRSISMLDGNKQRQKQYVSLKLEGILESAINICVTYDPTRFGPFVLGRTSIEETGVYSVACAIQNLWLAARAEGVGVGWVSILANEDLEKILAIPPHVKPIAYLCLGYVSEFAEKPDLERAGWLPRMDLASVVCYEQWGVHDSKSWSSLCAIMGKMSEGNREDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN1</accession>
    <name>K0IHN1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histone acetyltransferase, ELP3 family</fullName>
            <ecNumber evidence="15">2.3.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Ngar_c03740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="15"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03740"/>
    <dbReference type="EnsemblBacteria" id="AFU57322">
        <property type="protein sequence ID" value="AFU57322"/>
        <property type="gene ID" value="Ngar_c03740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03740"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.361"/>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_2"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-374-MON"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="72"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="389"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFU57322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="527" mass="59736" checksum="8D4EA18238B1371D" modified="2012-11-28" version="1">MTDNNNSSYQQACRSIAEQIESRKLLSVRQALKVVREVASAYHLDTMPKNEHIIHHIHDNRYRRLLMVKPAKTASGVAVVAVMPKPYECPHGRCTYCPGGIEFNTPLSYTGTEPATKAAQKFSYDPYQQVCGKMEQLQSRGHDTGKTEIVIVGGTFPFMPADYQREFAKSCYDALNGRRSSSLQEAISINETADNRCVGFTVETKPDYCKEPHIDLMLELGVTRVEIGVQSLRNSVYKLVNRGHTLDDVVDAFRIARDAGYKIVAHMMPGLPGSSPEKDVEDFRRLFEDDAFKPDMLKIYPTLVLEHTGLFRMHKAGKYRAYSDDDFVNVIVEAKKVVPEWVRIMRVQREIESKDIVAGPKSGNLRQIVLQRLRQQGYRCRCIRCRETGLQRRYPDEDEVTLRRTDYSASGGREVFLSYESKDGDTILGFLRLRRVAKPHRNELGGAAIVRELHVYGQAVSVGSKEIDGSYQHRGYGTKLLREAERIAKDEFGVTKIAVISAIGTRQYYKKKLGYCQDGPYVSKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN8</accession>
    <name>K0IHN8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas2</name>
        <name evidence="9" type="ordered locus">Ngar_c03790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c03790"/>
    <dbReference type="EnsemblBacteria" id="AFU57327">
        <property type="protein sequence ID" value="AFU57327"/>
        <property type="gene ID" value="Ngar_c03790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03790"/>
    <dbReference type="HOGENOM" id="CLU_161124_2_0_2"/>
    <dbReference type="OMA" id="IDIFPIC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10641" checksum="C1D00908CF30CB1B" modified="2012-11-28" version="1">MRYIIVYDITDDNLRTLTSETLKDYGLKRIQKSAFMGSLKKHALNSLLTDLRRMVNVDSVIVFPLCDSDFRNMVSIGKEFVEEEKQDVQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHU1</accession>
    <name>K0IHU1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ISCpe7, transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c05030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57447">
        <property type="protein sequence ID" value="AFU57447"/>
        <property type="gene ID" value="Ngar_c05030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05030"/>
    <dbReference type="HOGENOM" id="CLU_043491_0_0_2"/>
    <dbReference type="OMA" id="DANTRFM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-501-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="195"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU57447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="378" mass="42958" checksum="CABFB6C9C0146BB4" modified="2012-11-28" version="1">MQTQPTANNSEARMTRGLQILKGKQIVENTDGSFAVPSQTSKNIYEVRLLGQAWACTCPDFEFRQIDACKHIFAVKMFIAANVYLKEEPKPKVFASDAIPCVRCGSIRVIHYGVRSGKQVYFCKDCKRKFGEQSLLKKVQFTPELITLTLDLYFSGLSLRKVARNISDHFNIHVEYTTIYSWIKRYVPMIAEYVNTLAPKELSDTWHVDEMFVKLKGGQFHKSGARIGFLWNIMDRQTRFLLSSKLSEERDKIGGIAAFKEAITNAHGLIPNEVRADSLNSYPHIVKTTLPNAKLIAKCGIRKPHTNNNRIERLNGTLRERVKVQRGWKTISTPLAEGQKLQYNFVKPHMALDGQTPAQVAGIQVKGWGELLKRSLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHZ2</accession>
    <name>K0IHZ2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c06090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urea transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06090"/>
    <dbReference type="EnsemblBacteria" id="AFU57552">
        <property type="protein sequence ID" value="AFU57552"/>
        <property type="gene ID" value="Ngar_c06090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06090"/>
    <dbReference type="HOGENOM" id="CLU_047509_0_1_2"/>
    <dbReference type="OMA" id="GLHGFNQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-607-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="PTHR10464"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU57552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="372" mass="39882" checksum="55804F1471C92249" modified="2012-11-28" version="1">MAIPTYSTGDPALDFFFTLFNGIAEVPLFSSPITGILILAGVFLASRKAGAMMVLAGLIGAGVAILAGADYGLVTFGLFGYNSILTGMAFWSGPFVKANKATFFISVFGAAITAFSWMAFAHLMGDMFALGSTAAGWAIPGFTSSFIFTTWALMYATKRFGHDIWPAPAPPPKEELIAGSGNPMTSDAGSFKWTPKEFMIATLKGVSQVTFVENWKTGVFWVVGLTLAFELAPFIAGVQDRPWWTNGYTAQWNEFSPLYLAGLMALLGSGIGVAMAILTKLPTAEIRMGLHGFNQVLVMIALTSFVPLTPQSFMMAVFATIGCCFLMPALQRFFGQWGLPALTGPFVFTAWIFLLATSGFQNIPAGLGWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0II32</accession>
    <name>K0II32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC efflux transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Ngar_c26640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26640"/>
    <dbReference type="EnsemblBacteria" id="AFU59585">
        <property type="protein sequence ID" value="AFU59585"/>
        <property type="gene ID" value="Ngar_c26640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26640"/>
    <dbReference type="HOGENOM" id="CLU_039483_6_0_2"/>
    <dbReference type="OMA" id="AWIFKTG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2664-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="255" mass="27421" checksum="621453FA80E9FD43" modified="2012-11-28" version="1">MNAVAILLYRNLVASIDKVFLVWQVVFPIVYIFIAGYSYSALIGEGGVPVGSAFIAYPAYLAAGMIGFNMMNSSTIAGSIIWNDKRNGMFQQILVMPFARMEYIAGSIITIMLMGLASAGLILVAGTPTLVGSAVPTLVGSMYVLYALITGAIFFGSIAIIISTRLKSNEGFNVIVNSVFLFFSFVSTAFYPTQGVPGALSTAFYFNPLTYIVDITRAGIFNQIDFFTNVEVGIIAAITAAAFFLATLSMLRMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0II47</accession>
    <name>K0II47_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58618">
        <property type="protein sequence ID" value="AFU58618"/>
        <property type="gene ID" value="Ngar_c16850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16850"/>
    <dbReference type="HOGENOM" id="CLU_3039179_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1683-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6049" checksum="E225503DBA7E7A6C" modified="2012-11-28" version="1">MSWKSDAAGSYNAKMFVLDYIGDTPMIPSERHQKDISNIAYRDAPSIILICKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0II52</accession>
    <name>K0II52_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/opine/nickel ABC uptake transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dppC</name>
        <name evidence="6" type="ordered locus">Ngar_c26890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26890"/>
    <dbReference type="EnsemblBacteria" id="AFU59610">
        <property type="protein sequence ID" value="AFU59610"/>
        <property type="gene ID" value="Ngar_c26890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26890"/>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_2"/>
    <dbReference type="OMA" id="IKEQTYV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="257"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="462" mass="50654" checksum="CC9918C466FC9402" modified="2012-11-28" version="1">MTAAKVVSRSELLREFRRSKSGLAGAGILLVLILMTTYAAVAVPLESFRQWNNPNFWIDTPKSAAPAWTNLFGPKVPEHIFMTAKDAAVSSSVQGGVRTVTHSYTVNFNYDSYPSDFMMLYSARYGSTQPALQIDVLRPDGKEFRIYFASLPSSQQGSNEFSARVFSTDRLIADNLRNYLDDFAYRQDVSRPQVMIFSDSQQDSVLKGTYVIRETFYLFDSNDSVTNSGVILGGEVYGLMGTDELRHDLAIGILWGAPVALFIGLTVSIAGMIIGLIYGVIAGYKGNRTDEGLMRINDVFYSLPPLPLLIILSITVGKSIFLITGFLVIFGWVGMAKISRSIALQLKNLQYVEAAKLMGQSDRKIIFKHIIPQLLPLTFASIAISVPGAILGEAMLSFLGLGDPSIPTWGQILHDANSAGAASRGLWWWIIPPGLMIAITGLAFVLIGNALDAIVNPRSRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0II61</accession>
    <name>K0II61_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c17050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58638">
        <property type="protein sequence ID" value="AFU58638"/>
        <property type="gene ID" value="Ngar_c17050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17050"/>
    <dbReference type="HOGENOM" id="CLU_2748322_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1703-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8088" checksum="127CB32DFCF6134C" modified="2012-11-28" version="1">MSELAPQPQQPDQPVTATEEQLQEPMQQFNIILACRPCSVKMNFTYRNPDRKPSRCIYCGRRAEEMIESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0III6</accession>
    <name>K0III6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59710">
        <property type="protein sequence ID" value="AFU59710"/>
        <property type="gene ID" value="Ngar_c27890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27890"/>
    <dbReference type="HOGENOM" id="CLU_2032933_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2789-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="121" mass="14014" checksum="8787434130B23285" modified="2012-11-28" version="1">MEYSNDIIICSKSKSLLELDCTITANGHSFTANGSFLVPDKKGKLRGILYAYPNENKIGSWNGEIKIDAEYLHEWKNGFYDVTGRPQINQKIRFKYQGRQFAGIWHNKNWSSIVRVREVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK4</accession>
    <name>K0IIK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57912">
        <property type="protein sequence ID" value="AFU57912"/>
        <property type="gene ID" value="Ngar_c09700"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09700"/>
    <dbReference type="HOGENOM" id="CLU_2230461_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-968-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="105" mass="12167" checksum="B1D9D80E0046F7C9" modified="2012-11-28" version="1">MATINQLRFFIDGYHIYNNYVRPHTCLLSEQQTPAEATKRLRSVALNLQNRLKDLIVKSAEQKEIILMTITRRNREPGLSIYVCVYMVAVVVMSQPSIKKCRVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIS1</accession>
    <name>K0IIS1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59850">
        <property type="protein sequence ID" value="AFU59850"/>
        <property type="gene ID" value="Ngar_c29320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29320"/>
    <dbReference type="HOGENOM" id="CLU_1237951_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2932-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="223" mass="24441" checksum="1EA5BF533F8F8D41" modified="2012-11-28" version="1">MSSPIATQILSFENFGALENHLRSLKNRYNDLIKKYEETLGFILRDTKPTSAKSQKVQEKWALEMQRAMAATTTAAAAAAKSAKGTPLAKKEESKPKLLFGNGKDKEKDKERLGDDSGEWIPLDPMSLFIGKKNRGLAEIYFDTINILRENVSKINTALSVCSALKAKAATAGSTSLVVSFVNDIPTKVMLKPLRDDGSKKYTMAFSFAVPSMPPAAKSHIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ08</accession>
    <name>K0IJ08_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58127">
        <property type="protein sequence ID" value="AFU58127"/>
        <property type="gene ID" value="Ngar_c11870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11870"/>
    <dbReference type="HOGENOM" id="CLU_2490567_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1185-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9510" checksum="82F9507C920D5690" modified="2012-11-28" version="1">MAKTRKGFGAKPRGTAKHKGAKGQSYKRKDKNKIKTKAKTANRNLDTRQQRIAMAKATRANENMDRNRSLNEAAPAATSDTEPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ59</accession>
    <name>K0IJ59_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58232">
        <property type="protein sequence ID" value="AFU58232"/>
        <property type="gene ID" value="Ngar_c12940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12940"/>
    <dbReference type="HOGENOM" id="CLU_2204002_0_0_2"/>
    <dbReference type="OMA" id="MSEINEF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1292-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12341" checksum="8A822782A590D0E8" modified="2012-11-28" version="1">MHDESTRYRINQLTDTGTTVNLALSEDVELETVSQQQMMLEAVDRAVADKEVKEQIKPILEAILRSQPQTVIKSYSQTVIQITMPKKRYEKIGSPRVGDRLLIDIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ81</accession>
    <name>K0IJ81_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60060">
        <property type="protein sequence ID" value="AFU60060"/>
        <property type="gene ID" value="Ngar_c31440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31440"/>
    <dbReference type="HOGENOM" id="CLU_1773260_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3144-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="15853" checksum="E00C5C61EC48CDCF" modified="2012-11-28" version="1">MAGHRNQRHGKRKKKKAAEANPTKNGARVGYHSEAANPPELISETGANEGMEIGYHSEVANTSKTEEDVAGMQVGYHSERANPQRPNQNDGMKIGYHSEVANPPREGQDGMNIGYHSEAVNIGSHSKRLHGAKGSLEERADDASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ87</accession>
    <name>K0IJ87_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60070">
        <property type="protein sequence ID" value="AFU60070"/>
        <property type="gene ID" value="Ngar_c31540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31540"/>
    <dbReference type="HOGENOM" id="CLU_1387624_0_0_2"/>
    <dbReference type="OMA" id="MIYHHYL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3154-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="196" mass="21671" checksum="585E09FBAE074970" modified="2012-11-28" version="1">MLGSKVSIRLIRALVKYPDKIFTVRKLAEVAGVSPSEAALAVQELEKFGILTIQPVGRSYLISLNDKSYILNRILRPTVKAEEDTLHELVSILKRHLMTDKSIMSAVLFGSVAIGRERKDSDVDLLVISNDFEAASSIVSKAGDEISLVFNSRLSPIIMNGTELTSKKNDRLINSILNSYVVVAGRDLKEMIIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB1</accession>
    <name>K0IJB1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="4 9">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">purD</name>
        <name evidence="13" type="ordered locus">Ngar_c22580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="4 9"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22580"/>
    <dbReference type="EnsemblBacteria" id="AFU59188">
        <property type="protein sequence ID" value="AFU59188"/>
        <property type="gene ID" value="Ngar_c22580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2236"/>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_2"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="106"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU59188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="426" mass="46450" checksum="58C788341F6A04B5" modified="2012-11-28" version="1">MNVLIVGSGGREHAIGWKISQSRHVDKIYFAPGNGGTFENLDIKQNDIDKLVSFAKKQRSKKLLTIVGPEEPLSLGIVDAFEKEDLRIFGPTRQAAMLEASKAFAKELMREAGIPTAEFAIFTDAHKAKDYVSKQSKPLVVKADGLAAGKGVVVCDNADQAIAAIDSMMTKKEFGAAGSRIVIEERLSGEEASFIALCDGMTIMSLASSQDHKRVSDGDKGPNTGGMGAYSPAPVVDNDLYDKIVKRVMEPVTSIMKKRGTPFKGFLYAGIMVDQNGNPHVLEFNARMGDPECQPIMMRMESDLYEYVDAAVDGRLGSMPPIQWKDQTAVCVVMASRGYPGSYNKGEVIEGLDSKFGNDIMIFHAGTARDSQNRIVTNGGRVLGVTALGQNARQAIENAYSAVRKIRWGENGHYYRTDIARRAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJB2</accession>
    <name>K0IJB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L40e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl40e</name>
        <name evidence="4" type="ordered locus">Ngar_c14060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14060"/>
    <dbReference type="EnsemblBacteria" id="AFU58342">
        <property type="protein sequence ID" value="AFU58342"/>
        <property type="gene ID" value="Ngar_c14060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14060"/>
    <dbReference type="HOGENOM" id="CLU_175093_1_0_2"/>
    <dbReference type="OMA" id="FQYKICR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_L40e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="PTHR39649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L40e" evidence="3">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="55" mass="6224" checksum="7C8371A1D6C6B048" modified="2012-11-28" version="1">MPITDAAKKQIAQQRKLFFKICFKCGGKNPISASRCRKCHGSQMRLKNRTLGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC2</accession>
    <name>K0IJC2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59208">
        <property type="protein sequence ID" value="AFU59208"/>
        <property type="gene ID" value="Ngar_c22800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22800"/>
    <dbReference type="HOGENOM" id="CLU_1297522_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2278-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="212" mass="24144" checksum="EAB861C4DEC8D949" modified="2012-11-28" version="1">MENSKPPLLEQNSSGTDRLGKNKIAVLALWFGVLIGVRFLLGFVLQHTWIGTLGAVAITFAIFYLTLRYTQLQKYRQLINSSLNYWYRKKFFYISGMASLVILGGILGFIEYGYANYADRLIAVDFNQQEIEESFGVLTASEQMQAKLIENLQKYSPIEIIAITLASADKSLDGYYSLVVSYMFAEDIEIMIFMMLFRTRREIFTAKAPATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJC7</accession>
    <name>K0IJC7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0284 protein Ngar_c14260</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0284 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14260"/>
    <dbReference type="EnsemblBacteria" id="AFU58362">
        <property type="protein sequence ID" value="AFU58362"/>
        <property type="gene ID" value="Ngar_c14260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1392"/>
    <dbReference type="HOGENOM" id="CLU_053134_0_0_2"/>
    <dbReference type="OMA" id="TRWVAED"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1424-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01086">
        <property type="entry name" value="UPF0284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="entry name" value="PTHR38811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00303">
        <property type="entry name" value="TIGR00303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="36927" checksum="3BBFBEB9055AADC9" modified="2012-11-28" version="1">MRDIAASHKLAIKRFAAKNPVFVCVISYTATSEIPGLTVAGANPELVKYTSPADAEFLYYGRCRCIDAVPATPDGKPTPALITRAALQAAGIPLLVVDAGAKVKPSIPCVSFGLEPGRNIANENAMDYHMVVQAFGHGELLGKQLAALSDLVVIGESIPGGTTTALAVLGALGIDARFKVSSSMPENPHSLKNSVVASATKRAGSIITRSPFEAVAAFGDPMMPSVAGIASGALAAGGRVMLAGGTQMSAVVAILKRIGRPLSSLCIGTTTYVAKDPSADLAGLVKAASGQVPVLSCDLHLGESSKPGLQAFAKGFVKEGVGAGGSSIAAMLKLRCRITGEKLLKAIEKEYETSIGTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD1</accession>
    <name>K0IJD1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="1">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">tgtA</name>
        <name evidence="3" type="ordered locus">Ngar_c32140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32140"/>
    <dbReference type="EnsemblBacteria" id="AFU60130">
        <property type="protein sequence ID" value="AFU60130"/>
        <property type="gene ID" value="Ngar_c32140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32140"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3202"/>
    <dbReference type="HOGENOM" id="CLU_030083_0_0_2"/>
    <dbReference type="OMA" id="FPCSCPV"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="500" mass="55991" checksum="8834E8F18C47C05E" modified="2012-11-28" version="1">MFVFEVRYSDLAARVGRLETPHGVVETPAFVPVVHPVRQTVSTQFLKKMGFGIVITNAYITLRHYGDEARRRGIHDIIGYDGAVMTDSGGYQVLEYGSVEVEPAAMAQFEKDIRSDIPIPLDKPTGYGLDYERAKEYVATTLKNSQETLDVVGNTDAIWVGPVQGAEHSDLVEHSARELGRMGFKLMALGSPVELMEAYEFATLARMIVAAKKVIPAKPVHLFGAGHPLTIPLAVALGCDMFDSASYMLYAKDGRYMTPNGTVRLDELVYLPCQCPVCSSHSLQELRGMNGDERVIEVAKHNLHVLKAEVDAVKQAIMDGRLWEYVMQKARAHPKLMEAVQLFKDIEMLESGTPLFKERAIFFYDPIDQHRPEAKRFRRAAAGFQSSKKKLVLCPEGEVHPFYSTRSYREIVKRLPDAQVCSYSPFLGIIPAEISDIFPAAHNLATRYGHRPEDYPTFIESLKEFVKKFEQVTIIADDFMEQAAKAARLNARLVNDISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJN5</accession>
    <name>K0IJN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58492">
        <property type="protein sequence ID" value="AFU58492"/>
        <property type="gene ID" value="Ngar_c15580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15580"/>
    <dbReference type="HOGENOM" id="CLU_2010163_0_0_2"/>
    <dbReference type="OMA" id="LEMHEYK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1556-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="11955" checksum="25C79319528485A4" modified="2012-11-28" version="1">MRREYIIARIEASQDGSPYVYVTFNDPKEYKPDRPNMNPFGSGVATFNSIEDLMKNMPKVMANIPGLGGGLTESPTIKLSMREYQDMGIKVGDKVYIEIQKTESSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJS0</accession>
    <name>K0IJS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59468">
        <property type="protein sequence ID" value="AFU59468"/>
        <property type="gene ID" value="Ngar_c25460"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25460"/>
    <dbReference type="HOGENOM" id="CLU_1965640_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2545-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="15030" checksum="71F3CF8DA9B5459E" modified="2012-11-28" version="1">MKGRKSIASGDEVPTEKWLVAYRNPTSKRHPGGSVFMRQFYAPGYYEAYDTVLTHAEKMNLEVLWFREKRSCEPFLNRDFPELEAICTYCNKRFNHTEPVPCSHEGCNAEFCSRDCMSEHRAMRHRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJS1</accession>
    <name>K0IJS1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">purL</name>
        <name evidence="9" type="ordered locus">Ngar_c15890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c15890"/>
    <dbReference type="EnsemblBacteria" id="AFU58522">
        <property type="protein sequence ID" value="AFU58522"/>
        <property type="gene ID" value="Ngar_c15890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15890"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1557"/>
    <dbReference type="HOGENOM" id="CLU_003100_0_1_2"/>
    <dbReference type="OMA" id="FIEPYQG"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="74"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="192"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="427"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="556"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="724" mass="78188" checksum="AFA8B2DD76EED56A" modified="2012-11-28" version="1">MGVLTKQELDYLEENLKRKANEVEQDIVGAEWSEHCSYKSSKKYLRLLPTKGKRVLVGPGYDAGVLDIGDGYVLTVHIESHNHPSAVEPFGGAATGVGGVIRDIMSMGTRPIAVLNALRFAPITGKSKAVAKSKWLFKNVVKGIADYGNCIGIPTVGGEIEFDPSFEDYCLVDVASIGFGRKEDIVANQADVGDVIVLAGGSTGRDGIHGASFASKALEVENRSAVQIPDPFLEKLLLEATMEAVKQGCIKGIKDLGGGGLSCCLSETSDTLGKGFDVELTRVRARESGMTPNELMISESQERMLYITDKTRLPALQLILDKYEISYSVLGEVQGHRDLVVRHGGRVVAKMPSHLVAHAPLADRATKRPAYLDRLKSSVKQPKMPANLGKTLLSLLSNPTIASKSWVYQQYDHEVGVRTVVKPGMGDAAVMRLDNGRFVAIKLDGNSKHCYLDPYQGTLGCLSEGCRNVICAGAEPIGVVDHLQFASPEDPEIYWTFTQAINAIVDYCKFMDVPVVGGKVSFYNETAKGPIKPSPVMGMLGLIENESQITRPSLSSGDSIFIIGNTAPEMGGSEYYEYVHNITGGPVPKVNLQVDKQNRNTVQSLIRSGLVTCTHDCSKGGLAVALAEMAIAGSTGFKVDLDAVPNSCDRMDDLLFSESHSRYIVGTKEPEKVRKALSSAGVTFAQIGSATSAVKFTKGKKKVIRLTLKQLQTSFYSLGKVMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ2</accession>
    <name>K0IJZ2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="8">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpA</name>
        <name evidence="10" type="ordered locus">Ngar_c16640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16640"/>
    <dbReference type="EnsemblBacteria" id="AFU58597">
        <property type="protein sequence ID" value="AFU58597"/>
        <property type="gene ID" value="Ngar_c16640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16640"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1639"/>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_2"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="28975" checksum="A4F95F9279AA8A77" modified="2012-11-28" version="1">MPNRITEKFGELAGRDKCALICYVVAGYPDIKTSEQVIDALVKGGADIIEIGIPFSDPIADGPTIQAASNSALKRGITPEKALQLAKSVRKKHPELPLLAMTYSNILVHAGMEKFMSRAKSCGIDGFILPDMPVEEAESYSAAASKLGLATVFLASPNTSEVRLKKIVDSTSGFLYLVSVFGITGARKSFEDYTLNAVKSVKQAASGRVPVAVGFGISTPAHAKFMIEAGADAVIVGSAIIDMIAKSSGKKMLAGLQEFARSMKKACKKSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK10</accession>
    <name>K0IK10_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">prf1</name>
        <name evidence="11" type="ordered locus">Ngar_c16890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16890"/>
    <dbReference type="EnsemblBacteria" id="AFU58622">
        <property type="protein sequence ID" value="AFU58622"/>
        <property type="gene ID" value="Ngar_c16890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16890"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1665"/>
    <dbReference type="HOGENOM" id="CLU_035759_3_0_2"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="426" mass="47917" checksum="0F114D7E4A6BF561" modified="2012-11-28" version="1">MVNNNNNGDGKWDSVKRYKLTKMINELSSISGHGTELVTVYIPPRRPIFDVIAQLRNESGTASNIKSDLTRTHVQDALSRTIEQLKLFKETPENGLVIFCGAIPNDKGIGKEKIEIYPVIPPKPIQISLYRCDDHFWTDHLKEMMKDDKVIGILSIDTQETGIGILTGDRWEVVDTITSGVAGKHRQGGQSARRFERLRENELNEYYHRVADHVKKVFIDQYNVKGIILGGPGPTKENFLKEEYLDYRLQKSVIATIDSSYSGEEGVRELIEKAQKDGILQEYRVMEEKQLVKKFMSEVHSGRGLGIYGVHDVVRALEGGVADLVIVTDDISHVRLEFKCKACKNVQTKIVERAQVIATKQEYLTKPCPSCHATDIEPVEKDIVDYLNELATMTGARLEVISSKTEEGSQLASLGKIGAILRYKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK75</accession>
    <name>K0IK75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetyl-CoA thiolase or ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="3">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c17490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17490"/>
    <dbReference type="EnsemblBacteria" id="AFU58682">
        <property type="protein sequence ID" value="AFU58682"/>
        <property type="gene ID" value="Ngar_c17490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17490"/>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OMA" id="ALHVRRY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1747-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="233"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="367" mass="38903" checksum="729FBBB0622D10B2" modified="2012-11-28" version="1">MRRVAISSWATSKFAKDSKMPLLELACEPCADILKRNDISGKEIDAVLFSSCATDQYSSTIISEMLGMHPRISHRIDNLCNSGTNAVASAFAMIASGLCDSALVVGAEKADSPGNKLLWDITRGSFMFPAHWAAIFAKAHMRKYGTTEEQMARVSVKNHKNAAKNPQALFRKEVTLNEVINSKKIADPIKLLDCSAPCDGASAVLLVSEEKAKKLDNPVWIKGIGQQTNSASFANATTTGDLTTIGAAKRAARQAFEMSQAKPSQIDVAELHDAFTILEILAYEDLGFAKKGEGGRFVDQNQIAINPRGGIIGCGHPVGTTGVAQVAEIASQLAGKAGKRQVKGCKTGLVHNLAAAGSSATVIIMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC9</accession>
    <name>K0IKC9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nickel-responsive regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c27620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27620"/>
    <dbReference type="EnsemblBacteria" id="AFU59683">
        <property type="protein sequence ID" value="AFU59683"/>
        <property type="gene ID" value="Ngar_c27620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27620"/>
    <dbReference type="HOGENOM" id="CLU_113319_0_1_2"/>
    <dbReference type="OMA" id="KCLEVMI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2762-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="5">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="6">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14824" checksum="225E2D2989FE81C7" modified="2012-11-28" version="1">MSKGVTIVSVSLNEDIIGEIDKLQKELGFSGRSEIVRAGLRSLIAEEKERKNLAGNVHAVMLVIHDEKSDNEVNEMGHSFDSIITTHIHNKTGRDKCLEVFLLKGDAKEINEMVKRFKTNRKMDHVRLLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKH3</accession>
    <name>K0IKH3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58932">
        <property type="protein sequence ID" value="AFU58932"/>
        <property type="gene ID" value="Ngar_c20000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20000"/>
    <dbReference type="HOGENOM" id="CLU_2476128_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1998-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10220" checksum="C6E0581879153977" modified="2012-11-28" version="1">MVYIIKDWDVFKQAALLNSSCCNHNDLGCYRIIDRGREQEVKVLVGKFGYTGRFVSDDPEFEEIISFCQKQSFAEITGGHIEAGSFFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKM9</accession>
    <name>K0IKM9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21210"/>
    <dbReference type="EnsemblBacteria" id="AFU59052">
        <property type="protein sequence ID" value="AFU59052"/>
        <property type="gene ID" value="Ngar_c21210"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21210"/>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_2"/>
    <dbReference type="OMA" id="LEMAIHT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2119-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="165" mass="18463" checksum="BA0EAD8A98ECF8FA" modified="2012-11-28" version="1">MESCWPDNSILNAKARSDGIFFNSSSQRALAALFGEGGDNNNLWVMMRNISRMKKVEAIVRAERMPIVKEKLRQMGIGGMTISTVSGWSKQRELHLQWRGQPVAYDLLPRVKFEIVVPDEQTDKVVQTVIESARTGEHGDGVVFVSTIEQAFNIATLDKGEKVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKN3</accession>
    <name>K0IKN3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59057">
        <property type="protein sequence ID" value="AFU59057"/>
        <property type="gene ID" value="Ngar_c21260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21260"/>
    <dbReference type="HOGENOM" id="CLU_2476122_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2124-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9817" checksum="70BA050EDF8DB7FA" modified="2012-11-28" version="1">MEEDRIEYTGKVYVYSSGMPADHVQLAKEKLGEYGVNEGDIEVIEVPEGVPEGCIMVTVWPHYLSVAKVKRVRQGSIYAPQLFNIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP3</accession>
    <name>K0IKP3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59077">
        <property type="protein sequence ID" value="AFU59077"/>
        <property type="gene ID" value="Ngar_c21470"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21470"/>
    <dbReference type="HOGENOM" id="CLU_142654_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2145-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="13776" checksum="B653713332631B9A" modified="2012-11-28" version="1">MFTPIHEIGHRLVCISEGYQSVIAFDIRGGHQMCSGEVANQLLYNFAGGLSELIASVGLVLTGLLLLKKSGPVSDRLAFAVDIVMKIVAEGFLTEMYSPGVFDILITAIQLASLFGFVIYFAEKDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKP8</accession>
    <name>K0IKP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fumarylacetoacetate hydrolase</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21570"/>
    <dbReference type="EnsemblBacteria" id="AFU59087">
        <property type="protein sequence ID" value="AFU59087"/>
        <property type="gene ID" value="Ngar_c21570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2136"/>
    <dbReference type="HOGENOM" id="CLU_028458_4_2_2"/>
    <dbReference type="OMA" id="PPEPIIF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2155-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="264" mass="29888" checksum="0D62172DF43FAA06" modified="2012-11-28" version="1">MTKAEIQQQTGIPVPPNIKDFMFRGWLDEVRQHKNKLKYNHKVTDVELLVPIPNPPKIICLAFNYYDHARDAGLTPSDEPVIFMKPRTALNEPFKDVICPSFVTRLDYEAELAVIIGKETKKVTEEAALDYVFGYMIMHDVSARDIQFKDKQFTRGKGIDTFAPCGPWITTKDEVADPQNLQIITKVNDEMRQNSSSSNMVLPIRRIISALSRTMTLEPGDIISTGTPAGVAMSMKEPKYLKDGDVVEITIEKLGTIRNRIVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS3</accession>
    <name>K0IKS3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gvpA2</name>
        <name evidence="5" type="ordered locus">Ngar_c22070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22070"/>
    <dbReference type="EnsemblBacteria" id="AFU59137">
        <property type="protein sequence ID" value="AFU59137"/>
        <property type="gene ID" value="Ngar_c22070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22070"/>
    <dbReference type="HOGENOM" id="CLU_169045_1_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8321" checksum="C8F0204F554AFC6E" modified="2012-11-28" version="1">MSQQQSFRPILSIFDLLDRVLDKGLVIDANLSVSLVGIEILVVRARIVVAGVDTFLRYAAALGLAGPPALVAAQTSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT4</accession>
    <name>K0IKT4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59152">
        <property type="protein sequence ID" value="AFU59152"/>
        <property type="gene ID" value="Ngar_c22220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22220"/>
    <dbReference type="HOGENOM" id="CLU_2985814_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2220-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="54" mass="6247" checksum="18278BA095D4A7E9" modified="2012-11-28" version="1">MPEEEMISDDHRIAIEGWKARKDQLHKQQLSVMEINDEAEKVNLLSLSKQKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKT8</accession>
    <name>K0IKT8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisC</name>
        <name evidence="5" type="ordered locus">Ngar_c30670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30670"/>
    <dbReference type="EnsemblBacteria" id="AFU59983">
        <property type="protein sequence ID" value="AFU59983"/>
        <property type="gene ID" value="Ngar_c30670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3039"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_2"/>
    <dbReference type="OMA" id="YPDMACT"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="39953" checksum="8F4BA418DD615A9F" modified="2012-11-28" version="1">MKKNNSSSRFDDSIRRIAKLGHYTKPEKVQGAIKLDSNENFALDRDFVAGIAAEAARQVDLREYPLDQLDELYSQLAKYAGVSVKCVAAGSGSDQIIELLLSTLGSRRATVFSPTFSYFINRCELHGIKVDKVPLDQDFTLDKKEFVRSARKSDLIYICSPNNPTGNQIGRQEAIDIIDSLEDKLVLVDEAYVDFADYSLSTYATKRDNIIVLRTLSKAFGLAGARVGYMVANEKFVRTFRSTIQSPYPISTLSLAIASSVLARADHIRQTVNAVRNERGRVLAKLAKVDSIKVFPSDANFLFIEAGKNYQRISKVLKSSGVVVKELGSIAGHRGCMRVTIGTREMNDKFLQCIEEGSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKV8</accession>
    <name>K0IKV8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c31070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60023">
        <property type="protein sequence ID" value="AFU60023"/>
        <property type="gene ID" value="Ngar_c31070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31070"/>
    <dbReference type="HOGENOM" id="CLU_3075484_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3107-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041057">
        <property type="entry name" value="ZHX_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18387">
        <property type="entry name" value="zf_C2H2_ZHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="5856" checksum="86B10B594C43C88F" modified="2012-11-28" version="1">MSEAKGKFTCEACGASFYLHEDLVRHNANVHGAAIGTQLRQSEEIQKQREHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKW9</accession>
    <name>K0IKW9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative diacylglycerol kinase, catalytic region</fullName>
            <ecNumber evidence="2">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.107" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22620"/>
    <dbReference type="EnsemblBacteria" id="AFU59192">
        <property type="protein sequence ID" value="AFU59192"/>
        <property type="gene ID" value="Ngar_c22620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22620"/>
    <dbReference type="HOGENOM" id="CLU_045532_2_1_2"/>
    <dbReference type="OMA" id="GFDSRVN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2260-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="331" mass="35334" checksum="A128C9F5715775F8" modified="2012-11-28" version="1">MKNIGVQVRAKQRAFDTALIVNPNSCSGLTGKNWDELYAKMEKIFGGRIKVAFSKKSGDGTVLARDMLRKGFDKVIAIGGDGTINEVANGFFEDTTGVRGHKLRLINPDAIMGVVPCGTRNVLVKSLGLPAGVVECCQNFVGGNPTKIDVIAISATNPDNGFRLRPRIFLNAAEIGVGAEIIDRSKKVRSKIKSRIVSTAAAIISTVPSYESNACDLFIDGRKKSTNMTMAVVANGKFLGGGFMAAPEASMSDGLLDLLVLKDSGSLKMLDEMANIKAGNYAGEDNILYSKAKKVLIKSMEREVTVTVDGEPIGILPATFQVFPKALTIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB6</accession>
    <name>K0ILB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59412">
        <property type="protein sequence ID" value="AFU59412"/>
        <property type="gene ID" value="Ngar_c24900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24900"/>
    <dbReference type="HOGENOM" id="CLU_123710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2488-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="13635" checksum="0C70295644F6856C" modified="2012-11-28" version="1">MSKIDRVKDCVMTNNSKLALAVGLAAAALALVLPNLAGGIAVLGLSLGTALNISSLVLSAAAFAVSWKQRSFLVAGLLAAAGVIYMIPGLVALASINFAVIVFPGPILGVIFGLIVFGLGVAKGIRTARAVTVAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILE7</accession>
    <name>K0ILE7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">Ngar_c34480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34480"/>
    <dbReference type="EnsemblBacteria" id="AFU60363">
        <property type="protein sequence ID" value="AFU60363"/>
        <property type="gene ID" value="Ngar_c34480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34480"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3446"/>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_2"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="187" mass="20617" checksum="DF249A9C6A03977E" modified="2012-11-28" version="1">MRLVVAITGASGVIYGIRTLEVLRELRVETHLIMSEWGAKNIKIETDKTADYVRSLATKCYEDDNMAAPMSSGSFRTDGMVVIPCSMKTLASIANAFDDSLVSRAAGVCIKEQRKLVLVPREAPLSKIHLENMSKLADAGAVILPAMPGFYHRPKTMDDLINHVVGKLLDQFNIDHGLFRRWGGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILG4</accession>
    <name>K0ILG4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25550"/>
    <dbReference type="EnsemblBacteria" id="AFU59477">
        <property type="protein sequence ID" value="AFU59477"/>
        <property type="gene ID" value="Ngar_c25550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25550"/>
    <dbReference type="HOGENOM" id="CLU_099871_0_0_2"/>
    <dbReference type="OMA" id="FPVWGAP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2554-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="23183" checksum="4ED76939AD799B2A" modified="2012-11-28" version="1">MSFFKRIRDNIINSKRLSKADSEILFSISSIHVTLEVKLGLKVTGRCALTFKTVSGTFFYEMEQDIRRFLSSLQPEFDLAFRTVTDSYGYMWVVFEGKRIEDLLAGLTATGDIVEERGFSDQLLAAVFEFANERHGGQQQYLIYNYRRNNFYPFVPTGNKTRNIEQEMKMMSAIGEEMPFEKDMTLWYPLWDLPLRSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILK0</accession>
    <name>K0ILK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57124">
        <property type="protein sequence ID" value="AFU57124"/>
        <property type="gene ID" value="Ngar_c01750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01750"/>
    <dbReference type="HOGENOM" id="CLU_1017867_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-175-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="30437" checksum="08F220B190A6DCEC" modified="2012-11-28" version="1">MATQTSIYPHEVGRDLIPELATRVYSSQLDSFREAISNAFDEGSKQVALAITKDRIVIEDWGGGIKDYDEFRKFGQASKKSRKGEIIGEKGLGKLSLLNLGRTVRFETNNSSIGMRFYMTLAGFTKPEYGKAGSFLSHRGTKITVTKLANTVDTSEVASYLRKAFGLRLVRGADITINGEPVKPRFAFDPKETLLFRLKHNIDVTGNVRFSEGGKGAVDVYIDHVFVTSLEVDMRRKFEGGSTAMILHQRHQGTISFKTKFTRSSLSSFDNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILP9</accession>
    <name>K0ILP9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxyacid dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">serA</name>
        <name evidence="5" type="ordered locus">Ngar_c26760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26760"/>
    <dbReference type="EnsemblBacteria" id="AFU59597">
        <property type="protein sequence ID" value="AFU59597"/>
        <property type="gene ID" value="Ngar_c26760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2651"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="YGNIGTQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="7"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="311" mass="33618" checksum="BECAFD344A4349E2" modified="2012-11-28" version="1">MQVSGKVLICDSIDQAGIDSMKRAGLTVDYKPEIKPAELTSSSVKDYDVIIVRSRTKITKEVIDAAANAKIIARVGVGLDNVDVRAAEAKKIRVINAPEAASVAVAELAIGLMISLARSIPRADAEGKRGNWIKKELMGTQLSGKYLGIVGVGNIGRNIGRMAKALRMNLIGYDPYPINREFISETGMIVTDLNTLLESSDFVTCHVPATPETRHMFNAERLAKMKPTAYLVNTSRGEIIDENALYEALKNGKIAGAALDVFEIEPPTNKQLLSLPNLICTPHIGAQTKEAQELASTVIAEKVIQILRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILW1</accession>
    <name>K0ILW1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59722">
        <property type="protein sequence ID" value="AFU59722"/>
        <property type="gene ID" value="Ngar_c28010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28010"/>
    <dbReference type="HOGENOM" id="CLU_2629856_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2801-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8593" checksum="2F6D8B26EFE6C0C9" modified="2012-11-28" version="1">MEELQASPVANLKKAVQQEFTRIVPSLEKARKGEIEAALSKVAAKLKIDNKVLDYRLSKDDQGALYITITICVTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM09</accession>
    <name>K0IM09_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57494">
        <property type="protein sequence ID" value="AFU57494"/>
        <property type="gene ID" value="Ngar_c05510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05510"/>
    <dbReference type="HOGENOM" id="CLU_2433698_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-549-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="104" mass="12284" checksum="DD7F32BAF39094B9" modified="2012-11-28" version="1">MTLEKRERAEEDDDSMIYRCPDGHISFAKQLQYCGMKGCGKPIEIISEQDIEWLYKINPSGLAMNEKDLNKILEDKNMPNEVKEAVKQVFPELKEKKKRRFWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM45</accession>
    <name>K0IM45_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57549">
        <property type="protein sequence ID" value="AFU57549"/>
        <property type="gene ID" value="Ngar_c06060"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06060"/>
    <dbReference type="HOGENOM" id="CLU_2911645_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-604-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="6372" checksum="98C154D65EF122AF" modified="2012-11-28" version="1">MIFGPLESSINAATQVGLLIIGLVIGLHHSIEADHLAAVSTMVTTANNKSSKFRAPMLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM48</accession>
    <name>K0IM48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase, CDC48 subfamily protein</fullName>
            <ecNumber evidence="5">3.6.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c30810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30810"/>
    <dbReference type="EnsemblBacteria" id="AFU59997">
        <property type="protein sequence ID" value="AFU59997"/>
        <property type="gene ID" value="Ngar_c30810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3053"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="HACHDIK"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3081-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="210"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="483"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="721" mass="79344" checksum="1CBAE3EA0A043569" modified="2012-11-28" version="1">MSQNTLSLKVLEAYTRDVGRGVARIDYDSMDSLGASTGDVIEIRGKRRTVAKCLPLYPSDEGKGIIRVDGLVRNNAGIAIGDTVIVKKIKAVPAEKVIVAPLEAIPPIDERYLADALESVPLIKGDNVMVPYFGGRLTFQVIGVTPAADAVLVTQKTIFHIAEKGETLRGVPQVTYEDIGGLKEEIQKVREMIELPLRHPEIFEKLGIEAPKGVLLYGPPGTGKTLLAKAVANESNAHFISISGPEIMSKFYGESEARLREIFKEAKEKAPSIIFIDEIDSIAPKREEVTGEVERRVVSQLLSLMDGLEARGKVIVIAATNRPNAIDPALRRPGRFDREIEIKVPDKRGRLEILQIHTRNMPLDTDVDQDKIAAVTHGFVGADLEYLCKEAAMKCLRRVLPELNLEDEKLSPEVLNKLVVTMSDFENAVKEVMPSAMREVYLESPDIPWSAIGGLEEVKRELQEAVEWPLRYPDLYTKLGHTMPKGVLMHGPSGTGKTLLAKAVATESEANFISVRGPELLSKWVGESERGIREIFRRARQAAPCVVFFDEIDSIAPTRGMGGDSMVTERVVSQLLTELDGIQALSGVVVIAATNRADMIDPALLRPGRFDKIVFVPMPDKAARQRILEIHAKGKPMGPDVDFAKVAELTEGFSGADTSAVANTAVSLVLHEYLAKYPTPEEAAKHASEAHVMLRHFEEAVRKIKTQREGKPTEKAVPYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM66</accession>
    <name>K0IM66_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c31260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31260"/>
    <dbReference type="EnsemblBacteria" id="AFU60042">
        <property type="protein sequence ID" value="AFU60042"/>
        <property type="gene ID" value="Ngar_c31260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31260"/>
    <dbReference type="HOGENOM" id="CLU_640330_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3126-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="181"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="450" mass="50198" checksum="9C2A433CBECDB930" modified="2012-11-28" version="1">MTSFLAEAGFAASEHETIQVLSTPDRVKRHYLNLVRIARSEILLTFPTVNTIHREREIGIVDELKKAVKRGVQIRILSPEDDFIKDKLDELRSSGVVIRRIETPTETKLNMIIVDKKVLLVVETKDDARRIFSQAIGLALYSNSKATVVPCASIFESLWRETYLYEKSRDAERIKGEFVNIAAHELRNPIMPILNGADLIQQGLMKHKDKFRKEDFEELFSSASLVIRNASKLMKLSEDILQVSRIESGVLSLNLEEVDLEKLVNTVIADIEKKYLGERDDVRIIFDSKLDIADSSSSGSSSENGTKIYCDGPKIWQTLYNLIDNAVKFTESGEVGISASVFKGEVMIQVQDSGKGIDPEIMDRLFEKFASKSNGGTGLGLFVSKKIVEAHGGRIWATQNKEKGGAIFTFTLPTDLLPEIPEEEISSAKDDKAASYASSQENVTGFKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI8</accession>
    <name>K0IMI8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57929">
        <property type="protein sequence ID" value="AFU57929"/>
        <property type="gene ID" value="Ngar_c09870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09870"/>
    <dbReference type="HOGENOM" id="CLU_3113193_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-985-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5830" checksum="66033EC4561B3401" modified="2012-11-28" version="1">MAAWKCKICGREHRDELSLMEHVSGHLRQYLFAGSSKRVKKPKEERMAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMZ5</accession>
    <name>K0IMZ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58484">
        <property type="protein sequence ID" value="AFU58484"/>
        <property type="gene ID" value="Ngar_c15500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15500"/>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1548-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="368" mass="41024" checksum="771B6AC7F0266B95" modified="2012-11-28" version="1">MGIDVELVTLEKPEAVSIRDAYGTSIDRDVKRIRTLSLSQIAGTKSHGVTINTHGDMLPFFRHNFAKNNAITYCHYPIAGQLIDSGDSSYYNILQNMNLSTTTPKCRSMYFEIARDACNKMMTNSTVLTNSEFSRKAIFKTHGVDSTVLHPPVDVDTFRNAALSSDARDDSILVISRFHPSKKIENAIHFAKLLRQNELGSRMNIVGNISPDGASYFNYLRHLVRCYGLEDFIRFEVNASFDRLLGLMRISKAYFHPLPGEPFGISTVEAMSAGVIPIVPDTGGHTEFVPAKYQFHTFDQAVEAVAAALDAPASERIQISYFTQKYSTANYIRGFQKIVAEVSDIGKKPLEQTPVISMPKRFPESMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN20</accession>
    <name>K0IN20_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c16760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16760"/>
    <dbReference type="EnsemblBacteria" id="AFU58609">
        <property type="protein sequence ID" value="AFU58609"/>
        <property type="gene ID" value="Ngar_c16760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16760"/>
    <dbReference type="HOGENOM" id="CLU_887447_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1674-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="132"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="313" mass="35973" checksum="BBBD9316D5219114" modified="2012-11-28" version="1">MAKGSSGHHYHFLSWLTGEYVEGYVPEIDRAIMFLPKAIFLTSRRSARLLLGQKRRDKIKFLQRFWLADYESPSYHLLRLYHRKNRNKLIKVRVPKYGYSYLCRINSGDYTPSRELEVLQKFTPSSGDVVVDVGAHIGRYTIVSSKAVGPMGRVVAIEADPDNFKILNYNIELNELTNVLPLNYAAYSEDTRLRLYKVTSSEIYNTVMSSRAHSKNAYVDVDACTLNKILHLIGISRVDWIKIDVEGAEFEVIKGATQIMANNPGLSILIEVHNIDDDPQHYDRIKNFLESFGFCVKFELAYSSGERHVIFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH4</accession>
    <name>K0INH4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">leuC2</name>
        <name evidence="6" type="synonym">leuC</name>
        <name evidence="8" type="ordered locus">Ngar_c24550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24550"/>
    <dbReference type="EnsemblBacteria" id="AFU59379">
        <property type="protein sequence ID" value="AFU59379"/>
        <property type="gene ID" value="Ngar_c24550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24550"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2429"/>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_2"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU59379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="426" mass="46202" checksum="45BCA7222DFC8FD3" modified="2012-11-28" version="1">MTITEKILARAAGKQRLSPGDVVFAKVDKVMMHDVSGPGVIKVFSEWEKKGIKLDHIWDPNKVWVTEDHFVPAADRVSAENIITLSNFTKKYGINKHFKYGLGQYGICHTLSHEEAMVLPGEVYVGGDSHTNTTGAMGAFAAGLGHTDIAYVLMNGQIWFRVPETMLFKIEGTKPAHIMAKDIILRIIGDIGTDGANYKAMQFAGSVVKKLAMEERLTLTNMTTEAGAKNGIVEPDETTYAYLRERTDAKYSPVNGDPDAHYSEVFTYDIEKLEPTVAKPFSPGNISAARELQGTELDKAYIGSCTGAKLEDLREAAKILKGKKVKIRTEVLPAAQSIYAKAMKEGLINIFMEAGAVVGPPTCGACCGAHMGVLGKGEVCISTTNRNFPGRMGHVESKTYLASPIVVAASAVMGKITDPRDVKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INH5</accession>
    <name>K0INH5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59384">
        <property type="protein sequence ID" value="AFU59384"/>
        <property type="gene ID" value="Ngar_c24600"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24600"/>
    <dbReference type="HOGENOM" id="CLU_1965634_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2458-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14174" checksum="43DC7CC128CBEAF2" modified="2012-11-28" version="1">MLVAAVSIIGVALVAWSNFSFAMQQQTIANQTNSRINLINESFIIEDVWFYIQSGNYANVTIRNTGDLAIKVTHVYINNTQAWNTGKVIAAGTVEEIKVPTSWGPDRLQSIWVKTERGSEAKQVWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU5</accession>
    <name>K0INU5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30680"/>
    <dbReference type="EnsemblBacteria" id="AFU59984">
        <property type="protein sequence ID" value="AFU59984"/>
        <property type="gene ID" value="Ngar_c30680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30680"/>
    <dbReference type="HOGENOM" id="CLU_876084_0_0_2"/>
    <dbReference type="OMA" id="FNTFYLG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3068-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="311" mass="35026" checksum="24174C6AD4E92E98" modified="2012-11-28" version="1">MSFDCVLFDIDGVLVDIRKSYNAAIKKTVEYMLKSITDRRSFRGLVTDQIILKFRQSGGFNNDTDTTYAITLAMLASQPKSVAEGRKFLMKVAGNADEGGYVSVEKFLANYDIEKWKKLLNYPAPVKDSMLARVFDELFYGPELFRKQNSLEPKYWAGGKPFIKNDRIDVSIKTMKKLHEMFRGNLAIVSGRSRLAAEYSLRPVMKYFNLDACVFLEDEKREYAKPNPYAIKRAMKVMNAKTAIYAGDSAEDLLMARRAEKEAGVKIAFVGIYGNSPNPARTVAQFRQEGVEAVAKSVSQLIRIINAIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INU7</accession>
    <name>K0INU7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59994">
        <property type="protein sequence ID" value="AFU59994"/>
        <property type="gene ID" value="Ngar_c30780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30780"/>
    <dbReference type="HOGENOM" id="CLU_2115372_0_0_2"/>
    <dbReference type="OMA" id="RTIMVDL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3078-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="12279" checksum="45B88F8EBA239077" modified="2012-11-28" version="1">MFSEQPGRTPFESHLERLKEPARTIMVDLRNFTRSLGTNVIEEVRPHRVVYAKTMNFRTFLDIEPAGDSLVLSIRYGRAAPPVTATIRTTQDAESVKKQIADAYSKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ8</accession>
    <name>K0INZ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60249">
        <property type="protein sequence ID" value="AFU60249"/>
        <property type="gene ID" value="Ngar_c33340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33340"/>
    <dbReference type="HOGENOM" id="CLU_2257457_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3334-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="103" mass="12128" checksum="1DD1123BC344A18B" modified="2012-11-28" version="1">MLLRENSGKQIDGRTETKILEDLFDDKVNKAIDANRYQVREALKEIERNTRAFYLTNTEYHRRMMEEAKTKGDIATAIHHQVLMETYQGILKNFSLSESYDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP38</accession>
    <name>K0IP38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60449">
        <property type="protein sequence ID" value="AFU60449"/>
        <property type="gene ID" value="Ngar_c35360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35360"/>
    <dbReference type="HOGENOM" id="CLU_095961_1_0_2"/>
    <dbReference type="OMA" id="VAPDIWI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3537-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="217" mass="23672" checksum="52A9D189A9D03C86" modified="2012-11-28" version="1">MTGFDKNWSNQSRASASEKLKESLRPQGPLKPRIETAVNKLQLQTSKLDTMITKLNERDASLFRRVVDAMQRHDTDSAKVLSNELAEVRKIARTLGQARMALEQVSMRLSTIHEMGDAMVALGPAISSIKSLKPSLGRFVPGADSEINNMQTLLNGIMMESLQGSSVGIELNTSAGGADIDQIMMEASAVAEQKVNDKFPSIPAGSFRISDTESHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6W8</accession>
    <name>K0I6W8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57006">
        <property type="protein sequence ID" value="AFU57006"/>
        <property type="gene ID" value="Ngar_c00560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00560"/>
    <dbReference type="HOGENOM" id="CLU_3178698_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-56-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5603" checksum="EFBFFA69654FEC1D" modified="2012-11-28" version="1">MTQRKAVCIKIVQEVPERERMTSRTNPYQLLLRILSFKARWRPTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0I6Y6</accession>
    <name>K0I6Y6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57026">
        <property type="protein sequence ID" value="AFU57026"/>
        <property type="gene ID" value="Ngar_c00760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00760"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.78"/>
    <dbReference type="HOGENOM" id="CLU_820435_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-76-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="338" mass="36494" checksum="51AEB93ECB5B592D" modified="2012-11-28" version="1">MRKEHASNNTSKNKLLALAIAAALVASILSIVGGSIPSASAAEPKTINAGTGQGLLYYEAHRIPSSHWNPCFATSCDQGTGPGTWVWFVLFNDAGEPIVADLANEDGVLITGLEVGKTYFLQPTDCVYPNCGEPPHDVIFNNWHDCDDTRQRPFVIAAGTIVSGAAYYRYHLHGEPNEPVACFTTGTPNPPANNNPPPTNNPPQNPNQPTSPGTVETGMTDPVFYFKLVNFVNNEFGIGTVIAEENDTRTAAEILAEQIPDTNLSGQPLDSDSSLRYAMYNSLYEIVRDDPVSCMQIMRAAVDAGIPWDQLSDMQKAYIILKVKGSSLDATNVDFGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I792</accession>
    <name>K0I792_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57126">
        <property type="protein sequence ID" value="AFU57126"/>
        <property type="gene ID" value="Ngar_c01770"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01770"/>
    <dbReference type="HOGENOM" id="CLU_2968562_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-177-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="58" mass="6887" checksum="45D7F9AB9C327DD6" modified="2012-11-28" version="1">MIMIHFHMHFKRRFSLVLFPHIEQTFPWLLSSLSAILAAKFTIEYDNIVLEIKIAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8A3</accession>
    <name>K0I8A3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tRNA methyltransferase complex GCD14 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c05580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05580"/>
    <dbReference type="EnsemblBacteria" id="AFU57501">
        <property type="protein sequence ID" value="AFU57501"/>
        <property type="gene ID" value="Ngar_c05580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05580"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.533"/>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_2"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-556-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="31902" checksum="DED663F01686346A" modified="2012-11-28" version="1">MNILAKIEEGSYVLLFHTPRKKWLTKVTQDKKLHTHLGIIDISATIGMEYGSAIRTTEGKLVFLIEPTIHDFIMKSERRTQIVYPKDLGYIAARTGLKNGSKVLEVGTGSGALATFMASIVKPDGHIYSFDVNPEFMDIARRNLEKAGMSQYVTLHQHDPHQGVDVRDADIAIVDLGDPWTVLDQVHDALKGSGAFVAICPTMNQIEKTATELKKSGYADIDCVELMIRNIEAREGMTRPSMRMIGHTTYLVFARKVQKLQERVEAEAIAEEEGAEENDEENRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8K1</accession>
    <name>K0I8K1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c06680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57611">
        <property type="protein sequence ID" value="AFU57611"/>
        <property type="gene ID" value="Ngar_c06680"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06680"/>
    <dbReference type="HOGENOM" id="CLU_114386_0_0_2"/>
    <dbReference type="OMA" id="WKRGAYP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-666-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="214" mass="23344" checksum="BDF0FDA113E15130" modified="2012-11-28" version="1">MLIRTLTKVASRYAPSRVLSFDMVHIFKALQLMENEGHISRALLTKELGLGEGAIKTLVKHLKMQNLIETSKSGTRMTQKGRAICSALVSAVPAETRLPKCSVALGKYNHAVLLKNLSFAVKSGIEQRDAAVKMGAIGATTLSFKDSKFVMPMDSSGYDSLEKEPNIRKLLVEKLKPEEEDIVIIGSANDSSRTAELAAKNAALVTLVNHEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8P3</accession>
    <name>K0I8P3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57646">
        <property type="protein sequence ID" value="AFU57646"/>
        <property type="gene ID" value="Ngar_c07030"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07030"/>
    <dbReference type="HOGENOM" id="CLU_2519872_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-701-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9723" checksum="1B79B895988D8E11" modified="2012-11-28" version="1">MPIFLYREMQVPKLQNPILPSTDFADSRLSQDRLLLVGLRGTRKRTKNMIPARIRAFFLLFDAGIELLLYAKTTQKARRGTSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9K0</accession>
    <name>K0I9K0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c10690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58011">
        <property type="protein sequence ID" value="AFU58011"/>
        <property type="gene ID" value="Ngar_c10690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10690"/>
    <dbReference type="HOGENOM" id="CLU_1599070_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1067-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011094">
        <property type="entry name" value="Uncharacterised_LppY/LpqO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07485">
        <property type="entry name" value="DUF1529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="166" mass="17377" checksum="CD14EB8AE6D18638" modified="2012-11-28" version="1">MEVTDNATGANISNLLVINPIFEFTPVSGTNTSGTGNSTEDGATSNQTTTTTTGTSQRQEGNATTSAAGQGIVYGFAEIGGPEDQIPSLMRILSNSTWNVVAVHNHVTMESPKMMFVHAVGVSDIDTLTSEAKSILDGMAARQRTTTAGETTRSEMRGESNQTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IA05</accession>
    <name>K0IA05_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c12160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58156">
        <property type="protein sequence ID" value="AFU58156"/>
        <property type="gene ID" value="Ngar_c12160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12160"/>
    <dbReference type="HOGENOM" id="CLU_2629848_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1214-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8609" checksum="ABBF368C4ED3B2EA" modified="2012-11-28" version="1">MISIDDWQALVNKPVFTSDGKDVGVVTQIQPEKLVVSYGPITPDKYLIPKSSVKGIEKGVVYLSENGSFVERNYKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAE8</accession>
    <name>K0IAE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c13480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58286">
        <property type="protein sequence ID" value="AFU58286"/>
        <property type="gene ID" value="Ngar_c13480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13480"/>
    <dbReference type="HOGENOM" id="CLU_1965633_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1346-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14246" checksum="BFF8FAE45AC96C15" modified="2012-11-28" version="1">MSEPIKVFGDRAEQIKEGDTFRAVVKFIEGRKMVMLMKQERPESDSSSEQPKINAEPSESTAMNNKMRLLTKISGRPAEAIMKELLGSEAYFEFKDESRDDGQPVVAIYVEGNGSPMDKLENVEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAU0</accession>
    <name>K0IAU0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58451">
        <property type="protein sequence ID" value="AFU58451"/>
        <property type="gene ID" value="Ngar_c15160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15160"/>
    <dbReference type="HOGENOM" id="CLU_123710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1514-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="123" mass="12292" checksum="6D91730107E700C8" modified="2012-11-28" version="1">MTNSRFVLAVWLASTALVLFLVVIALGGALQAGLAPWPGIGLVVLATAAFVASRNQRSFLVAGLLVASGMVGLVYGLIVTGFFSVIVFPGPIIGVIIGVGIIGLGAAKGIEAARIGSKTATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBA6</accession>
    <name>K0IBA6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58591">
        <property type="protein sequence ID" value="AFU58591"/>
        <property type="gene ID" value="Ngar_c16580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16580"/>
    <dbReference type="HOGENOM" id="CLU_1943925_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1656-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="129" mass="14040" checksum="5B3660162FF4D362" modified="2012-11-28" version="1">MDNKQISSKRLRGRSAIEAAHASVTGEDEARLDATISKLYGVKSDEAAEIHINYHIDKILESLARRAGDNGMKRQALAERVQHLDVSGAASQVAKGKLTEAAAVDALFRSLSTIERGGKTIDDRFSIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBZ0</accession>
    <name>K0IBZ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">albA2</name>
        <name evidence="7" type="synonym">albA</name>
        <name evidence="10" type="ordered locus">Ngar_c18990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18990"/>
    <dbReference type="EnsemblBacteria" id="AFU58831">
        <property type="protein sequence ID" value="AFU58831"/>
        <property type="gene ID" value="Ngar_c18990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1883"/>
    <dbReference type="HOGENOM" id="CLU_110989_1_1_2"/>
    <dbReference type="OMA" id="KPTTNYI"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="9">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU58831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="108" mass="11657" checksum="617656C5B85B07C7" modified="2012-11-28" version="1">MSTNTANAANTNTVRSGKPSNEIFIGKKPLMTYVTATLVQLANEPTVVIKARGKSITRAVDVAQIIVKRMDTLGYKIGPIKLGSETVQSEDGRTRNVSTIEVPISRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICM9</accession>
    <name>K0ICM9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c21960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21960"/>
    <dbReference type="EnsemblBacteria" id="AFU59126">
        <property type="protein sequence ID" value="AFU59126"/>
        <property type="gene ID" value="Ngar_c21960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21960"/>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_2"/>
    <dbReference type="OMA" id="CFEYLLQ"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2194-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="252" mass="27098" checksum="F7EA9DC3E9F99886" modified="2012-11-28" version="1">MTVNAIFITGTAGSGKSLLTSRLIQWYRDNNAYPIALNLDPGAASLPYDPDVDVRDHIDIATIMESYGLGPNGSLVMASDMIATKIDEIQNEIDELNPDYVIVDTPGQIELFAFRASGPYFVASMHADNKATIFAFDGMLVSSPINFVSISLLASSVKLRLKTAQINVLTKRDLVIEKLKNIMDWAGSHTALEHALEGEKDAEYSLLSKDLARSMSKGGFAPGLVAVSSLTMNGMINLAAALARTLNLGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICX7</accession>
    <name>K0ICX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5'-phosphate oxidase FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22890"/>
    <dbReference type="EnsemblBacteria" id="AFU59216">
        <property type="protein sequence ID" value="AFU59216"/>
        <property type="gene ID" value="Ngar_c22890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22890"/>
    <dbReference type="HOGENOM" id="CLU_123922_5_1_2"/>
    <dbReference type="OMA" id="PRYMATW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2287-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="150" mass="17045" checksum="065E2380B954DCC8" modified="2012-11-28" version="1">MRFTLADRAAKPLDEGELSDLLNKPNILRLAMIDARDGMPLVHPVWYYYKDWKFFAAVDRDGAKARSLRKNPNVYFLVDIDPDDSPPRGVRGKGVAQVIDDPDYATKVTAHNVLRYLGSLEGKVAQKLIEMSKDSSVVEITPRYMATWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDA2</accession>
    <name>K0IDA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06970"/>
    <dbReference type="EnsemblBacteria" id="AFU57640">
        <property type="protein sequence ID" value="AFU57640"/>
        <property type="gene ID" value="Ngar_c06970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06970"/>
    <dbReference type="HOGENOM" id="CLU_2519871_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-695-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9826" checksum="CEFAA18EE8324989" modified="2012-11-28" version="1">MLKATGPWTLKPYQYHNYIFWPWITGIEMLARSRFARVEECNLLLTTLTSESKLNMHTFYEWVDPIKGEGNGAFHSEQGFLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDA8</accession>
    <name>K0IDA8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59381">
        <property type="protein sequence ID" value="AFU59381"/>
        <property type="gene ID" value="Ngar_c24570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24570"/>
    <dbReference type="HOGENOM" id="CLU_104053_0_0_2"/>
    <dbReference type="OMA" id="TIPSIYE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2455-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="183" mass="21417" checksum="AD2204598F1A290E" modified="2012-11-28" version="1">MPEFLTSYPKTISIVKGLQDFIRKEEIELDHLSLMVRTKKDEIINALISEGFKRVKLENRKPTQIGHGFSKKLAKPWEMHVRLLEMQQGLIAIHAEVEISRKYIQHIRSVRAPVIYEIESILKKHKIEYQIWHAKLKQYITTIIDNHQITLNAPRLPPLPWKHMAGSVVTLSLIYLAKFIGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDB6</accession>
    <name>K0IDB6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59391">
        <property type="protein sequence ID" value="AFU59391"/>
        <property type="gene ID" value="Ngar_c24670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24670"/>
    <dbReference type="HOGENOM" id="CLU_204996_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2465-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7433" checksum="24A07E36B53A07B1" modified="2012-11-28" version="1">MTTTFATDSFKVVNVSPISDQFKRLQVISCDISNVGRKSFNVLIDGIISEVTVLKRCCDKSVKSFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDJ5</accession>
    <name>K0IDJ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59471">
        <property type="protein sequence ID" value="AFU59471"/>
        <property type="gene ID" value="Ngar_c25490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25490"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2526"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_2"/>
    <dbReference type="OMA" id="IPGWVWR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2548-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="462" mass="49081" checksum="96F302504B5554C8" modified="2012-11-28" version="1">MILPAIPDFIRDFNISYSTSSWLLSAYVIAAAVMTPIGGRLSDIYGKKKILLIVMGVYAVGLLAGRFATNIEFMIAARAAQGIGMAMFPIAFGIIREVFPEKKLSIGQTIFSSTFSGGAIIGLVGGAAIIQNFGWPATFLAILPAAIALWFVIARYVHVPSQAARAEAGHQPNDRTIDIKGTLMLAVTIISFLAGITFLESHDSSAWYTIAGLFATSAASLAAFIAIEKRVPSPLLDLKLMTNKSFLPPTIILMLIFMSIFMVYLTIPILVRSPEPLGFGGDAVAVASVQLPFMVVLLIGTVMSGFILNKIKNTKLTLIGTLISAAGFFILLMFHSTEGMVSFGLAILATGLSLSITGAFNVILLSVPMQMTGIALGMTLLLNLVGQSVGPAAAGILQQMYRGTVEGVDRQFPTQDAYNLIFITAAIISLASVAMSLAVNRRKAVPVMVPKGAPPPKKDEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDS8</accession>
    <name>K0IDS8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetyl-CoA thiolase</fullName>
            <ecNumber evidence="3">2.3.1.16</ecNumber>
            <ecNumber evidence="3">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c00180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.16" evidence="3"/>
    <dbReference type="EC" id="2.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00180"/>
    <dbReference type="EnsemblBacteria" id="AFU56968">
        <property type="protein sequence ID" value="AFU56968"/>
        <property type="gene ID" value="Ngar_c00180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00180"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.20"/>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OMA" id="GAERMTN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-18-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="259"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU56968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="389" mass="40789" checksum="CC8F56EAF6CAB8BC" modified="2012-11-28" version="1">MANSKVCVLGAGSTKYGKLNESIIEIALNAAKDAIESAGITPKDIQAGYISNVFGVADKQVHMAPVIMSNLGISHVPGLTIESACGSGSVMFREAYANVAAGFYDCVLALGVEKVTHTGTVHSTTLFSYCSDFFYEGGNGASFPGLFASMARAYMNTHKATEEDLAHVAVKNHENGLLNPKAHVRKKITVDDVLKSPVVASPLKLLDCCPFSDGASATILCSEEFAKKSGRPYVEIIGSGRGASPAAVQGREDITTIPSTVAAARQAYKMAGVTPKDINFAEVHDCFTIAEVIDIEDLGFFPKGKAAHAVRDGATRLNGEIPINPSGGLKSKGHPIGATGVGQVVEVFEQFTGMAGERTVPNAEIALTHNFGATGASAAVHIFKKVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDZ4</accession>
    <name>K0IDZ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archaeal thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ths</name>
        <name evidence="6" type="ordered locus">Ngar_c00930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00930"/>
    <dbReference type="EnsemblBacteria" id="AFU57043">
        <property type="protein sequence ID" value="AFU57043"/>
        <property type="gene ID" value="Ngar_c00930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.97"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="QTGSNDM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="555" mass="59575" checksum="CFD1BC42106D20E1" modified="2012-11-28" version="1">MASIQTTAGGMPVLILKEGTKETKGKEAQKNNITAAKLIAEIVKTSLGPRGMDKMLVDSLGDVTITNDGATILKEIDVQHPAAKMMVEVAKSVDNEVGDGTTSSVVFAGALLERAEELINKDVHPSVIVDGYNAAADQALKLLEKIAVKVDIADKDMLLKITRTSMDSKLVSDDSPVLAQIVVEATKQVAEKTESGGLKVDLDDIKVEKKAGGSMRDTKLIKGIVLDKEVVHAGMPKKVENAKIALINSALEIEKTEMSAEIRISDPHQMQMFLEEENRMLKSMVDKIKSSGANVLLCQKGIDDIAQHYLAKAGILAVRRVKESDMTKMSRATGARIVNNLDDLTAKDLGSANLVEERKVETDKWVFIEGCKNPKSVSILIRGGSQRVVDEADRSIHDALMVMKDVLEHPAIVAGGGAPEAYIANELRQWASSQEGRAQLAVQKFADALDAIPLNLAENAGMDPIDTMTELRASQSKGAKWTGIDCRNTKVTDMYKQNVLEPLVIKQQIIKSATEVVSMILRIDDVIASGKSKMPAGPPGGGGMGGGGMGGMDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE62</accession>
    <name>K0IE62_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27250"/>
    <dbReference type="EnsemblBacteria" id="AFU59646">
        <property type="protein sequence ID" value="AFU59646"/>
        <property type="gene ID" value="Ngar_c27250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27250"/>
    <dbReference type="HOGENOM" id="CLU_2420147_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2725-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10208" checksum="86951A6166234141" modified="2012-11-28" version="1">MEDSYGKGCQILHLVNNGGGEPTSRKDFLELIQHLKSLHLPVTVVTNRSFLHTFDIKILKENIDSLCVSVDSIHKDLYCKIRGVLQNNTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IER5</accession>
    <name>K0IER5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c13120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58250">
        <property type="protein sequence ID" value="AFU58250"/>
        <property type="gene ID" value="Ngar_c13120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13120"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1260"/>
    <dbReference type="HOGENOM" id="CLU_000288_47_1_2"/>
    <dbReference type="OMA" id="APEDRYF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1310-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="239" mass="25925" checksum="F8934D10EEE8394C" modified="2012-11-28" version="1">MASKTMILAAIAVGVIVAGVATAFMMSSSAVPATITNDKPAAAKSADQIITQLASPSIASAPALGSDDAKVTIVEFGDYQCTWCYRWHEGTKDVLVADYVDTGKVRFLFKDFPINDLSDRASSLAAEGSYCAADQGKYWEYHDEVYSNWNGENTGWVTRDSLERFAKDAGVQDLSAFSDCLDSGKYARVVRDNYNLARSIGLDATPSFIVLIDGKTPQLIRGAHPYSTFERVINEAYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF76</accession>
    <name>K0IF76_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58445">
        <property type="protein sequence ID" value="AFU58445"/>
        <property type="gene ID" value="Ngar_c15100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15100"/>
    <dbReference type="HOGENOM" id="CLU_2285134_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1508-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="101" mass="11755" checksum="E277A82C5980B3E2" modified="2012-11-28" version="1">MFRSKKLKTIASISIQFCNQSSNKLFVISLHKVYSCCRSCDQESVDIIVMSNNDVQQQQQILKDGIEDEICDKCRKEKAELFQLTGEYCLKCWQIMTHPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF83</accession>
    <name>K0IF83_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57478">
        <property type="protein sequence ID" value="AFU57478"/>
        <property type="gene ID" value="Ngar_c05350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05350"/>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-533-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="81" mass="9329" checksum="6BDA5F5C23E150B5" modified="2012-11-28" version="1">MTCKGLCVRYKAPKPPAHVGGRYGIGQKRCQVCSMFIEWNDLWCPCCHFRLRIKPRNPKSKKRILLAVAANSKTRRLANTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF98</accession>
    <name>K0IF98_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <shortName evidence="1">PGP</shortName>
            <shortName evidence="1">PGPase</shortName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-phosphoglycolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal SPP-like hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c05550"/>
    <dbReference type="EnsemblBacteria" id="AFU57498">
        <property type="protein sequence ID" value="AFU57498"/>
        <property type="gene ID" value="Ngar_c05550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05550"/>
    <dbReference type="HOGENOM" id="CLU_044146_2_0_2"/>
    <dbReference type="OMA" id="DTGYAYH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-553-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01419">
        <property type="entry name" value="GPH_hydrolase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006382">
        <property type="entry name" value="PGPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="236" mass="25379" checksum="EF53D8D43893D225" modified="2012-11-28" version="1">MAAIKVFAVDIDGTLTENGGGAIHLAALAKLRYLERLGYNVVYVTGRSSIEAYVLAVFGGTTRIAVGENGGAITIAPQEHKLLASREKCMEGYEVLKKSIDGVQIKPVFPRMTEVVLLRTFDLKEGQKILEEHNLPLYLSDSKYAFHINEKGVDKGYGLAEALKMLKADPEETVAIGDSETDVPMYGICGCSIALGHAEESVKKKADHVVAGSEGAGLAEAIDYVAFNYLGVKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFB2</accession>
    <name>K0IFB2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57518">
        <property type="protein sequence ID" value="AFU57518"/>
        <property type="gene ID" value="Ngar_c05750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05750"/>
    <dbReference type="HOGENOM" id="CLU_3057245_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-573-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5815" checksum="38B7D64604066FE8" modified="2012-11-28" version="1">MYAGFIYCAVGLDLLQQHHIGALLFANFNGELLAHTTKNINTGRAIDIRIDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFB8</accession>
    <name>K0IFB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58505">
        <property type="protein sequence ID" value="AFU58505"/>
        <property type="gene ID" value="Ngar_c15720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15720"/>
    <dbReference type="HOGENOM" id="CLU_2433959_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1570-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="9615" checksum="0AE4984C6AC98DA8" modified="2012-11-28" version="1">MASCSWQEFLINPQATSISCIGGFFSWASGGIVGGINWIGEQIKIGLKGFADALRPYWVYIAGGLVVVFGILVWKYGIVGAFGKVVSKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFP4</accession>
    <name>K0IFP4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative proline dehydrogenase</fullName>
            <ecNumber evidence="6">1.5.99.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c32560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.99.8" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32560"/>
    <dbReference type="EnsemblBacteria" id="AFU60171">
        <property type="protein sequence ID" value="AFU60171"/>
        <property type="gene ID" value="Ngar_c32560"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32560"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3251"/>
    <dbReference type="HOGENOM" id="CLU_061158_0_0_2"/>
    <dbReference type="OMA" id="YPMIGSH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3256-MON"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="5">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="273" mass="31280" checksum="7504D4E52211F349" modified="2012-11-28" version="1">MAKKWVAGYDAGEAIAAALDSNSRGMSAILNFLGEDTTDAKIVDQTVREYLSLMDLIGKRQVRGCVSVKPTQLGLAIDYDMCLQNFKRLTARAKELDQFMWIDMESVKFTEDTIAIYLELYKQYDMTGVAIQSYLRRSASDLLHIAEHGGKVRLVKGAYHEPEEHAFSTKEEVDANYVKLMRMLFESGSFFAIATHDSNMIEEAIRLSNDSTKEFEFQLLMGIRDELKNELTTKEFAVAEYIPYGSQWLPYSVRRIRERKRNLLLLARSLIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFQ8</accession>
    <name>K0IFQ8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c17170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17170"/>
    <dbReference type="EnsemblBacteria" id="AFU58650">
        <property type="protein sequence ID" value="AFU58650"/>
        <property type="gene ID" value="Ngar_c17170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17170"/>
    <dbReference type="HOGENOM" id="CLU_045498_5_4_2"/>
    <dbReference type="OMA" id="MYHHIIN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1715-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="256" mass="26458" checksum="2B9EE27B7654C89E" modified="2012-11-28" version="1">MLDPITTIVVLIAVGLGAGTLGSMIGVGGGIIMVPALTFLGLPPAQAASTSLIAVTSTSVSSTIEYSRQKRIDYRLGLTMSAFAVPGAVLGAILSESVSVESFKLYFGILLMFAGIYVLYKNSILKDSAAKKRSMAYAAVFPATFGAGIIASLFGVGGGIIFVPLMLLVLGLTMPRAVPTSQLTLMTTSIAGIFAHGLLGHPDYLQAAALSAGAFAGAQIGARISRTTKDVLLQRLLGLALIAVAIEFVIDWFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IG80</accession>
    <name>K0IG80_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MBF1 (Multiprotein Bridging factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34930"/>
    <dbReference type="EnsemblBacteria" id="AFU60406">
        <property type="protein sequence ID" value="AFU60406"/>
        <property type="gene ID" value="Ngar_c34930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34930"/>
    <dbReference type="HOGENOM" id="CLU_130237_0_0_2"/>
    <dbReference type="OMA" id="VQCEMCG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3494-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="140" mass="15638" checksum="8A2CE66443883A1F" modified="2012-11-28" version="1">MSYCELCGRQTMEKKMVIVDGTVFNVCIACSKHGKPYAPAQVAAAKKKKPMAVIRQQKKIGLADATVLTPDFARLIREARMKMGLTHEQLGMKMNEKAQLLRKFETGALKPDELFAKKLERYLGIKLYVSAEGSGDDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGC0</accession>
    <name>K0IGC0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57873">
        <property type="protein sequence ID" value="AFU57873"/>
        <property type="gene ID" value="Ngar_c09310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09310"/>
    <dbReference type="HOGENOM" id="CLU_3210875_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-929-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="44" mass="5073" checksum="CFD43FF64BA19C3F" modified="2012-11-28" version="1">MDLVTYHWSGKHHDVVKGINLITLLWSDGKALVPTDFRLYGDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGQ3</accession>
    <name>K0IGQ3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59010">
        <property type="protein sequence ID" value="AFU59010"/>
        <property type="gene ID" value="Ngar_c20790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20790"/>
    <dbReference type="HOGENOM" id="CLU_3094230_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2077-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="5572" checksum="BEF758E660956364" modified="2012-11-28" version="1">MPNQGLGREMGKEEEEGSADDVNVQEIASDPHTGNTGIETSFSHVRKTKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGT7</accession>
    <name>K0IGT7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c21240"/>
    <dbReference type="EnsemblBacteria" id="AFU59055">
        <property type="protein sequence ID" value="AFU59055"/>
        <property type="gene ID" value="Ngar_c21240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21240"/>
    <dbReference type="HOGENOM" id="CLU_2783847_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2122-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7943" checksum="9C8E78BAB75E532F" modified="2012-11-28" version="1">MLFGKKKEIKPEIYSEDTCQSCGENTKRQFEEGDYVYGTGLQCKKCSSSNTLVTAIYGEYPPDDKSSSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGX1</accession>
    <name>K0IGX1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57062">
        <property type="protein sequence ID" value="AFU57062"/>
        <property type="gene ID" value="Ngar_c01120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01120"/>
    <dbReference type="HOGENOM" id="CLU_191934_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-112-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="85" mass="9967" checksum="1580CE4C8FA7DE3F" modified="2012-11-28" version="1">MFIMGRGREVRKRIETSLCVPSQKVLGEKKETLLQMIRKVGNTEQRKVNDILHKISRARERKKEKERELVNIAKQNNACIFCLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGY7</accession>
    <name>K0IGY7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57087">
        <property type="protein sequence ID" value="AFU57087"/>
        <property type="gene ID" value="Ngar_c01370"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01370"/>
    <dbReference type="HOGENOM" id="CLU_2821036_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-137-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7617" checksum="4C6D1EB34C1FB4D3" modified="2012-11-28" version="1">MLISLMTLQNRLLVAYWNTYAKTGQYLAHKDVFLRSALTSQGMAEQLCNDPQRQRNRKGNLILSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH18</accession>
    <name>K0IH18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate/guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c11880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c11880"/>
    <dbReference type="EnsemblBacteria" id="AFU58128">
        <property type="protein sequence ID" value="AFU58128"/>
        <property type="gene ID" value="Ngar_c11880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11880"/>
    <dbReference type="HOGENOM" id="CLU_057456_1_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1186-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="247" mass="27855" checksum="4A1365314EBE0CC7" modified="2012-11-28" version="1">MQDIHRAHWLAAKCRLLSPIRDFNSIQTRVRQTLDKGVQIDLSTESCKRFLRRRVNQKISVVILYVDIDGSTKMSMSLAPDKFATILHIFSQEMSLVIAEYGGYVLKYVGDAVIALFPAEYDSSQASRNAIECAKSMQEIIKQCINPELRSHGLPEIRAKMSVDNGDVQVVLYGKSIERSHIDIVGLSISMAAKMNPLAQAWHLVIGQSLYEKLANKDDFVEINIDPARWTYVDEKSGSGYKLYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH23</accession>
    <name>K0IH23_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c01630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01630"/>
    <dbReference type="EnsemblBacteria" id="AFU57112">
        <property type="protein sequence ID" value="AFU57112"/>
        <property type="gene ID" value="Ngar_c01630"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01630"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.162"/>
    <dbReference type="HOGENOM" id="CLU_1902001_0_0_2"/>
    <dbReference type="OMA" id="ECEFRED"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-163-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="133" mass="15029" checksum="CDC400BB92DFBDBD" modified="2012-11-28" version="1">MSDWIPLTVKFKGKCAECGKEIPQGERALWSKSSKAIKHIKCESPAAPEKKEEEEGKKKEEKKKKTPEVPELNCFICGRPAGCAECGFEIDCDRQAVSQACICSQCLEDKNAFENYQQAFIEKARRVAKNLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH38</accession>
    <name>K0IH38_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59175">
        <property type="protein sequence ID" value="AFU59175"/>
        <property type="gene ID" value="Ngar_c22450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22450"/>
    <dbReference type="HOGENOM" id="CLU_678999_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2243-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="394" mass="42257" checksum="37E59A6C08649CAA" modified="2012-11-28" version="1">MNYFSTNKLQAIAIISAIVISVGTGAFFALGSPIPKAYSQTSSSASLASSSNPTIRVTGDAMTSLMPDRATLVINVQSQPDDLSMVLNEHADKIEEIKQAVMAADDSAKVTVGHRNLSPYYSGGGVPASNDVTFNVYASVAIQTDIDHLSDLVSALAQAGFGFESVYIDPVYYSRLAQVAASTDAKGSVESGENVTDGVKNPITIGVSLNTKPDVLTSAIAEYEAKYRTLLSILEEQDISEDQIKQNNFNIYPQYYGSSQTATYQANTQIIVKTGVDNIQTVSSAIRQVDGVFVENVIISVSDEAIDNARQDLTQQAIANAQQRASEMVEPLGLEVKGIKSIEAVGSQGQNPYGGDVFYRGVKILQPYYYQSINGDISVSVMVEFEIGEETSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH79</accession>
    <name>K0IH79_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59250">
        <property type="protein sequence ID" value="AFU59250"/>
        <property type="gene ID" value="Ngar_c23240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23240"/>
    <dbReference type="HOGENOM" id="CLU_494026_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2322-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="551" mass="60307" checksum="3AA7F8B6DE9E41C8" modified="2012-11-28" version="1">MESVQENKEISREARVFANKTARSIAEIQQSVNNMADVLVFLEVLGYDDRTAKRNGFENLYELAKYVYNFVDAYDDDDKSHTSNSFAMEVPSTKKRLAESLSMIFPWLGSLVLLFLTGVSLWMAWDLPASVTTAFLAGVFLGLVVTEGLLQNYNRLFSFYYSQTNIGEIKRSIERSYVLAGVILSGTVALLYGVSELANIPLELAMIAAVSTVTISLHRISYVIMYALKKLTHIGISYAIALGVLAGVFFLAPDAIPDVTVRYFAALGSAFAVLSSFAMYHHYKIMGKSSTSIVAKNAPHFYSPLTVNDNTITSRFGVQLWECLPYFMYGTFYFILLFADRAISWFFNPVSVTAANGTILPLSFNSIYHIGADLALLVILPVAIMQYVITSPIYALVHNRAIVLKVSENKKIDWFLQYSYHKLMAASIAVSVAGALILNLVAPAIIIGYLGGSEVSMRILTFASAGAVFLSVFAANGVFMIFLGKVKALAQVSLAAAFIVIVGGTFLAQYGGFENIVIAYLAATVFAGMASTVAMRVAIRKAASLLFARYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH92</accession>
    <name>K0IH92_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation elongation factor EF Tu-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c23440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23440"/>
    <dbReference type="EnsemblBacteria" id="AFU59270">
        <property type="protein sequence ID" value="AFU59270"/>
        <property type="gene ID" value="Ngar_c23440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23440"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2319"/>
    <dbReference type="HOGENOM" id="CLU_077867_0_0_2"/>
    <dbReference type="OMA" id="MMDYALV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2342-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_EFTU_D2" evidence="1">
        <location>
            <begin position="155"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="310" mass="33520" checksum="7F4AE88BF59150C6" modified="2012-11-28" version="1">MNSINFVVLGDSSIAVQLGKKGTATDIVIYDRKTADTVYTWTAPTTFPDKIQSLMQAVNIAEYAILNVAKLDKFLGEQIMALDSVGLADGFVFHSYEVDREKLKMLLKGTTLANYQFVDSVDQLKQEMAKLKPKKNADGPLTIPIDHAFDVKGVGTVALGVVKQGTIKVYDELVLLPGKKNVFVKSIQMHDDPVESSSSPARVGLAIKGVSVDDISRGDVICAPDDAVKVSSGAIAVKFAKSPFFKGDLPENHTYMVSVGMQVKAAKVKFEGETLQVTPEKPIVYKQGQTLVLLKPDSQGTRIAGKGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF0</accession>
    <name>K0IHF0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58328">
        <property type="protein sequence ID" value="AFU58328"/>
        <property type="gene ID" value="Ngar_c13910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13910"/>
    <dbReference type="HOGENOM" id="CLU_1976608_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1389-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="125" mass="13748" checksum="5C412ED25C763783" modified="2012-11-28" version="1">MHRAVIFAGIVAAVAAVAGYIVYQQINRPPFALEVDAIKDTTDIGIQYRIRMTNVGTQQLTGIIVELGANDIQEKSFLNPGQSYYFYPDPETQVSKVRVKTNEGIMIESDYRSPTKVLGLPGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHF3</accession>
    <name>K0IHF3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ftsY</name>
        <name evidence="7" type="ordered locus">Ngar_c24360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c24360"/>
    <dbReference type="EnsemblBacteria" id="AFU59360">
        <property type="protein sequence ID" value="AFU59360"/>
        <property type="gene ID" value="Ngar_c24360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24360"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2407"/>
    <dbReference type="HOGENOM" id="CLU_039705_0_0_2"/>
    <dbReference type="OMA" id="SISAHFD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="114"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU59360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="490" mass="54404" checksum="1BE25000556A3294" modified="2012-11-28" version="1">MFDKLKKAFSSAAKGIGQKELTEQVLDDALLDLQIALLESDVAQEVVDDLSKKLKNELLGLKLEKNQDATQVVQSKLQAAVAEIFARAGRLDLTEKIKAKKDAKAGPFVIVFLGINGTGKTTTVAKVANLLRKAGFTVVVAAGDTHRAGAIEQLEQHTNRLSLKIVKQRYGADPSSVGRDAYEHAKKNFIDVVLMDTAGRMQTSKNLMDEMGKIVRVVKPDVKLFIGDSLAGNDTINQAREFFQYTNFDGAILTKIDADAKGGAAISIAHITSKPIAYIGVGQGYDDIIPFDPDKFIESLFGSVGEVSVENLMSMPRAPEPAKAPEAPVVEEKEEELPPPKPVEKPRPAIVAPPVQPPVQEKSAPKPVIREEPKPAPKIVEYTLPPPQSEREKEQEEPPLSPKIEEPPKEKKSRFSLFGGKKKTDDDRKKKEEEEKRCREEEERAREEEERARLEEEEEEKKKRKEDKGTGEQEDKVIYLTDEDIEDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHN9</accession>
    <name>K0IHN9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative blue (Type 1) copper domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c15130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58448">
        <property type="protein sequence ID" value="AFU58448"/>
        <property type="gene ID" value="Ngar_c15130"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15130"/>
    <dbReference type="HOGENOM" id="CLU_084115_4_0_2"/>
    <dbReference type="OMA" id="CSIHPFM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1511-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002386">
        <property type="entry name" value="Amicyanin/Pseudoazurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00155">
        <property type="entry name" value="AMICYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="3">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="135" mass="14090" checksum="BCADEE8359931A06" modified="2012-11-28" version="1">MVKKNVVVIASVVIAGAIVATYVLSGSMNMGVEGSGNRQEPVTPIPENSTVVKIVANAGSNSFSPNPAEVKVGETVTWVNDDSGGHTVTSKDGVFDSGMIGKGQSFSFTFDKAGEYQYFCEPHPNMVGTVVVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHR8</accession>
    <name>K0IHR8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57382">
        <property type="protein sequence ID" value="AFU57382"/>
        <property type="gene ID" value="Ngar_c04350"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04350"/>
    <dbReference type="HOGENOM" id="CLU_3057241_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-434-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="5956" checksum="AFCCB6221607639C" modified="2012-11-28" version="1">MVANSAYLSVSSNVINGFRVFRYLLAIMYPSLLATAQKRIDLSRDNIRSGKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIA2</accession>
    <name>K0IIA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57727">
        <property type="protein sequence ID" value="AFU57727"/>
        <property type="gene ID" value="Ngar_c07850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07850"/>
    <dbReference type="HOGENOM" id="CLU_1113903_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-783-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="28112" checksum="61E95444C924D5EE" modified="2012-11-28" version="1">MSSATYRRDLVWFSHAVNEYEILQVANAKKKFAFTDRVIKLDWDNCTVDVAKKLDDGKIRFVIRSKTNRNSDYMGSIPVQLRFMLGVDVDPSEISEPRLEKDYTLSASKRKNLPQSVKEIVHDRWVFDLGSRSQVWEWTRAGSADIRSSVVYGVYEKIRKYLEEAPTPASNNNIFRVEVEKLDDVVPVIYQPAVDSLDNFLREMHCAKSTNPDGSRISRSHCCSITSSCANSGLLTGSIGGLGRSFMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IID1</accession>
    <name>K0IID1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58738">
        <property type="protein sequence ID" value="AFU58738"/>
        <property type="gene ID" value="Ngar_c18050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18050"/>
    <dbReference type="HOGENOM" id="CLU_198710_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1803-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8435" checksum="5C77E35997896C58" modified="2012-11-28" version="1">MSEPVILHWERVIHKNVRSRDGYDIGNIISEAGDTITVMQGASREYNIPKSAVDGFNGSEVSLSMTYSEVQSYKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIE8</accession>
    <name>K0IIE8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb7</name>
        <name evidence="6" type="ordered locus">Ngar_c18400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18400"/>
    <dbReference type="EnsemblBacteria" id="AFU58773">
        <property type="protein sequence ID" value="AFU58773"/>
        <property type="gene ID" value="Ngar_c18400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18400"/>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="ESHYIDE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="313" mass="34490" checksum="27B91E99B2D0BA81" modified="2012-11-28" version="1">MYAKAGNMSYKLASEQAADVCALCNSKSIVFDSETSEAVCSSCGMVIKDNIESMGPEWRSYSGEDIESKSRTGMPSSLAFHDMGLSTFISYSNVDANGVAISAEQRSKVQRMRRWNKISSNNRSYHRNLKNAFAILSTIKDKLSLSDTLIEKAAYNYRKALDKKIIKGRSIRALIVAAVYAACRDLSVPRTLEEISAAANTDAIFAGKCYRLLVQNLDLRLPVIDSNKYLARISNKAKVSEKTYRNALEMLSTIKDNPISHGKDPNALAVAVLYAACLKEGENVSQAQVAVAGDISIVTLRKRFQDVRKIFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIK0</accession>
    <name>K0IIK0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59730">
        <property type="protein sequence ID" value="AFU59730"/>
        <property type="gene ID" value="Ngar_c28100"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28100"/>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OMA" id="FVYGPYD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2810-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9635" checksum="43FA7DE26F32B6B5" modified="2012-11-28" version="1">MPTAYVLINCDLGSEEEIIREIKKLPEAVEVSGVYGVYDIIAKIRSDSMDKLRETITWHVRRIDKVRSTLTMIVIEGQGEQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU3</accession>
    <name>K0IIU3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TatA subunit of twin-arginine targeting system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatA1</name>
        <name evidence="8" type="ordered locus">Ngar_c10950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c10950"/>
    <dbReference type="EnsemblBacteria" id="AFU58037">
        <property type="protein sequence ID" value="AFU58037"/>
        <property type="gene ID" value="Ngar_c10950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10950"/>
    <dbReference type="HOGENOM" id="CLU_086034_3_2_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="116" mass="12729" checksum="E0125D9D71A3C6F7" modified="2012-11-28" version="1">MEEASAALLMSIAGTEWIIIILLGLVLLFGTKKLPQFSRSMGKAMGEFEKARIMFKREMEEAADPLRSVSRIPKITGPVATEREKLETIANSLGIGGYAGMTDEQLRTLISKRIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU4</accession>
    <name>K0IIU4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29670"/>
    <dbReference type="EnsemblBacteria" id="AFU59885">
        <property type="protein sequence ID" value="AFU59885"/>
        <property type="gene ID" value="Ngar_c29670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29670"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2941"/>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="OMA" id="PVTMMFT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2967-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3" evidence="1">
        <location>
            <begin position="268"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="575" mass="65361" checksum="A65FAF75FE724198" modified="2012-11-28" version="1">MGRYPKVVLTADRTLMSPYRGISLASFFGCAPALDFNRDHNSFWYHVLGNQVTPRMLFDFICNPIDHTNGHANYAPYGLRKVEAALLRDGYSREDVIVAHPDHVEKFIGPETEVVGTYEMDPLGMGPVTMTFTYGRKHMSYDEFYNRDLHHRINAAKARTGSKAKVVAGASGTWQYNYDPAKIEEYGLYGIVEGELGGIGPEIDGAAGAFFDALIAGEFDTANPFKKSQFKVEIKEFVRNDRTLHGRFIHYWNEPSVDEIPNIVNPSMHGMIEVMRGCGRGCKFCDVTLRPLRYYPVEKVQKEIEVNMKYGGLKNAWVHSDDIFVYGLNPRTTKNMQPNREAIEELFKGIMATGIEHTNPTHGTLAGAIADERLIPNVSKIIKSGPNNHIGIQCGFETGSIRLIGKYADRKLSPYRPDEWHWVVKNGIKTLNENYWVPAFTLIMGLDNDETPEDSWETIRLIHEIEMEQPDSKFTTTPLTFVPIGLLEKSDFYDIGNTMDPAKLGVMYKTWQHNFKYGIQKFMSKVGRDNPIKNWFFTQLASTLGGVPLSAMERFARRKGPEHERVIEKIKANYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIU6</accession>
    <name>K0IIU6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58042">
        <property type="protein sequence ID" value="AFU58042"/>
        <property type="gene ID" value="Ngar_c11000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11000"/>
    <dbReference type="HOGENOM" id="CLU_1109528_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1098-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="285" mass="30063" checksum="881C0549ECB1EF64" modified="2012-11-28" version="1">MGMKIEKKNVVLLITTTLLLLPLLLFLPLSPIEVLAAVVINGTPRGETINGTPEPDTIKGFGGDDIIYGYDGNDMISAGAGNDRVYGGNGNDRIYGYKGNDVLSGDKGNDFIKDSYGDNKAYAGPGDDRIEFVHVDKFGGCSGESAYGGSGNDYVRIALGGGDCNMDVHLGIGDDIVICELGNCYTRGGLGNDKIYLNDGTETASTAALGGDGNDYLYGNGIHSLYGEEGDDTLEYGPMRGGPGADHFICNVEGSEVFDYNPDEGDTFEGKYCVDIDGNPLVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJD7</accession>
    <name>K0IJD7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58372">
        <property type="protein sequence ID" value="AFU58372"/>
        <property type="gene ID" value="Ngar_c14360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14360"/>
    <dbReference type="HOGENOM" id="CLU_198711_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1434-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="7357" checksum="36D983B447DBD380" modified="2012-11-28" version="1">MVLIHLQSRQQKEAEVISEILLKAASEPEFRNELIKDPGIVLEKYDVSPEAKLIIRRSIIDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJF6</accession>
    <name>K0IJF6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c23580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59283">
        <property type="protein sequence ID" value="AFU59283"/>
        <property type="gene ID" value="Ngar_c23580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23580"/>
    <dbReference type="HOGENOM" id="CLU_2177767_0_0_2"/>
    <dbReference type="OMA" id="RLYFLKV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2356-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="114" mass="13656" checksum="49AA8C778CD5BAA2" modified="2012-11-28" version="1">MVVYPETPIDYASGKIISGVKNLREGLDPDILAYWYKRVEDRSREVVPPHLKDKIHFQQDRILWMKFKMDVSKRAVPYVMQVIEEYIPMMPYSTGLYFRKVQEILTDEMNKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJK8</accession>
    <name>K0IJK8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59383">
        <property type="protein sequence ID" value="AFU59383"/>
        <property type="gene ID" value="Ngar_c24590"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24590"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2433"/>
    <dbReference type="HOGENOM" id="CLU_1773075_0_0_2"/>
    <dbReference type="OMA" id="YPDGDEW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2457-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="17274" checksum="5A0FAA1E0C654B33" modified="2012-11-28" version="1">MNLKEVNEVFRRAIIKAYFEPELLRMDYHRSSVKHPNIQEDGLTVEDVLHLYFDVSTGNDYPDGDEWFSIEYLLPYNVKLPDGLKGPDYFTTLSISEGKHYWRHRELVRFKYGKSKKLTESLEFIDKKYKELSKAVHSSPVINQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJQ1</accession>
    <name>K0IJQ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartokinase</fullName>
            <ecNumber evidence="3">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thrA</name>
        <name evidence="6" type="ordered locus">Ngar_c25250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25250"/>
    <dbReference type="EnsemblBacteria" id="AFU59448">
        <property type="protein sequence ID" value="AFU59448"/>
        <property type="gene ID" value="Ngar_c25250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2503"/>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_2"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="325"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="469" mass="49876" checksum="A4E53C55C548C480" modified="2012-11-28" version="1">MKFGGTAVDSPDKVRHVAQLVKSHKKGNNSNEIVCVVSAVRGMTDGLLSIADSVRRGDKTSIDEFVSKSAKIHTDIAEGAISDKKLKSEAVAAVKKVISELKDVLGGIVLLGEVTPKSLDYLMSFGERLSTPIVSFALQDIGIRSEYLTGKEAGVLTDGNFGEARPLMDTTKLRVSHKLEPMLKQDTVPVVTGFIGADQYGNITTIGRGGSDYTATIIAASIGAEEVWLWSDVDGLMTADPKIVKDAQVLKEVSFAEAMEMALFGAKYMHPRALEPVIDTKIPIRIRNTFNTKHAGTVITQNPGRESQKIVKSVSAIRHTALIDVSGGGMVGAPGTAAKIFDTLAKNRVNIMMISQSPSESSISMVVRKSDLDKATTTLELSLLGKVIKQINVNDDVAVIAVVGSGMRGIKGVAAKVFGAVAKRGVNVIMIAQGSSELNLAFVVNDSDCEQAVRALHDEFELARAAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJU5</accession>
    <name>K0IJU5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N(2),N(2)-dimethylguanosine tRNA methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.213</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trm1</name>
        <name evidence="8" type="ordered locus">Ngar_c34550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.213" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34550"/>
    <dbReference type="EnsemblBacteria" id="AFU60370">
        <property type="protein sequence ID" value="AFU60370"/>
        <property type="gene ID" value="Ngar_c34550"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34550"/>
    <dbReference type="HOGENOM" id="CLU_010862_5_1_2"/>
    <dbReference type="OMA" id="VFYNPVM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="386" mass="42791" checksum="D80BB9E846BA950C" modified="2012-11-28" version="1">MAAEEKEKKDFVRTVEGRTTFLVPQSSLTERVPPKTPAFFNPAARLNRDLSVLAYRAFAPSLTRKTFADSFTGIGARALRVAVEVPEIEKVYGNDINPVAIEAARKAAKINSVDSKCHFSIDEVCKFLLHGDSEGERFGIVDLDPFGTPAKHIDCVLRAVLDGGLVSITATDTAVLCGVYPEVCLRRYYGRPLNNSYGNETAIRLLLSLIALTASRLELSIRPLFVHAAMHYLRIYASVSVSSSEANDVYASIGYVMHCLQCGHRFKTEEYNNAKKCELCGSVMRTGGQLWTGPFHDREFVKKMMLEQSPDRQSKKVLDAAAEEESGIPYYFRADEISAKLRTNPHSVQNIIERLQSAGFVASKTVLNPSAFKTDARIDQILEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJV2</accession>
    <name>K0IJV2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c34650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34650"/>
    <dbReference type="EnsemblBacteria" id="AFU60380">
        <property type="protein sequence ID" value="AFU60380"/>
        <property type="gene ID" value="Ngar_c34650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3464"/>
    <dbReference type="HOGENOM" id="CLU_028221_0_1_2"/>
    <dbReference type="OMA" id="AGWVGIL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3466-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="330" mass="36061" checksum="7D9D6A927C6CC9EA" modified="2012-11-28" version="1">MVATAKRSNYFWKLMPTLSSAIRLPIENGGIVISVFKLQKQKPKSGYQRSIPFLLFVAAICLVFVDGIFRSDSPLARTQLQDPILLAAIYTVSLMGILGIHELGHVLANRKYGIKASWPYFIPGIPGILPTFGALIVLRANMTNRNVMFDVGVTGPIAGLIVTVIVSIYGSAISTLITTAEAERLFDENQLAPLPFGESLLMVATLHLTGMVVDGTVLVVSPVLFAAWLGFLITFLNLMPAWQLDGGHLTRSALGVRWHKVLTYVSIVILFALRFYPMALLVLFFSLRAPESAPLDDVTPLSSKRKAFFFLALGLAVVCAPIPTSLMPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJV9</accession>
    <name>K0IJV9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60390">
        <property type="protein sequence ID" value="AFU60390"/>
        <property type="gene ID" value="Ngar_c34760"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34760"/>
    <dbReference type="HOGENOM" id="CLU_161796_0_0_2"/>
    <dbReference type="OMA" id="CAKFAST"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3477-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="139" mass="15536" checksum="ECC958C719DBA9C7" modified="2012-11-28" version="1">MSLSSTFQRPLLIYDDKCYSCTKFAKAASMLSRGWIRVAGHYYSQEAKEAKEMIFPPGYDATKMFWLVNKDGAYGARSGLLPVVREIIVGLFRGGKASDDDIAAAACEYDGTSMSCYTPTNVFKRLATMLRHGAKFRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJW3</accession>
    <name>K0IJW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NorQ like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c34810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34810"/>
    <dbReference type="EnsemblBacteria" id="AFU60395">
        <property type="protein sequence ID" value="AFU60395"/>
        <property type="gene ID" value="Ngar_c34810"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34810"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3482"/>
    <dbReference type="HOGENOM" id="CLU_1044353_0_0_2"/>
    <dbReference type="OMA" id="CALFEHA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3482-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="276" mass="31117" checksum="115C7EB539C966E2" modified="2012-11-28" version="1">MESPTAKISPEEIIYLDWNNALEILEKAHKSGLFVLIIGPKGTGKTTLVRKFASRMKKDLDSVNFSLRTRESHLVGSRTLDKGEISFVEGVLVKSMRSGTILYLDELNAAEADVLLRLDEALDDRRQLVLKEAEGQVIKATDDWFVIATINPLSHVGTKELPPQLLSRFPVRMRLEYPPEEVELEIVRRHVTIDESKVKDVKHAIQLAKNLREAAAVEELYYSPSLRETIAFAKMLNAGLSGRSAAEVVYANAYDQWGQVEYQKVMDMITSIFGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJW8</accession>
    <name>K0IJW8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phoU1</name>
        <name evidence="2" type="ordered locus">Ngar_c34920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c34920"/>
    <dbReference type="EnsemblBacteria" id="AFU60405">
        <property type="protein sequence ID" value="AFU60405"/>
        <property type="gene ID" value="Ngar_c34920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3494"/>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="HSWRIAQ"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="360" mass="40813" checksum="7B5682D39A376F87" modified="2012-11-28" version="1">MENNNSEGNSNGENLLQGEETRKLQYTGGSSYIVSLPKKWIQDLGLKQGDHVVILRQGNSVLQIAPASKRMAKEQKEATIEVGKDNNPYFIARKLIALYFLGFNVITIVPKEDRLLVEQREVIKSIVRRVLMGTEIIADSATGITLQVLINLLDLSVDAAFKRMLLIAKSMYRDTLLALKENNVELAEEVVKSDDEVDRFSFYIVRQLKIAIKNEHLLKEIGLEEPRNCLGYRLIAKSVERVADHAVIIAKDIMENPHPLNKDIVEKIAGMSYFALEVLDDACLSMFKRDYEAADRAIEKARKIDEVEKIILKAVSEPRDVSELYRIKLITENIRRVAEYASDIAEIVLNMTVQQTLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJZ5</accession>
    <name>K0IJZ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truD</name>
        <name evidence="4" type="ordered locus">Ngar_c26260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26260"/>
    <dbReference type="EnsemblBacteria" id="AFU59548">
        <property type="protein sequence ID" value="AFU59548"/>
        <property type="gene ID" value="Ngar_c26260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26260"/>
    <dbReference type="HOGENOM" id="CLU_005281_4_1_2"/>
    <dbReference type="OMA" id="GFPNYFD"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="3">
        <location>
            <begin position="163"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="420" mass="47628" checksum="4BE2C8219377FCFB" modified="2012-11-28" version="1">MTLYVSKIDRLAGIECYCTSFAGTGGSIKQRSEGFRVSELVDELLVGNISLTFDNRHRYPLYILEKHDIDSNHALFEIERECRMRLRVMGIKDAKAVTTQYASADRVMRNPPGELKTKHTRLTLEGFTRRPLGKEFLAGNKFEITIHRPRSHDLSGLLPEIDKVGNFYGLQRFGSERLVTHLVGREIVKRNFRRAVELLLSYTTEYDTPASKEIRSKSADPGNYRQVLRILPRGMDIERQVLTALVAGKDAVSALRTVPITIRRLFVQAYQAYIFNKCLSTAVINGEDLLQPAAGDLCFEMEGPATFGRIIKYDHASKAKKMVPAIRMAGYTFQPGKGRFENITKAILQEEGVTAKDFYVKEMQELSHQGGFRQAPLWCMDFSYSKNPQLIVSFKLPKGSYATTLLREIIKPQDPIRSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK81</accession>
    <name>K0IK81_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59643">
        <property type="protein sequence ID" value="AFU59643"/>
        <property type="gene ID" value="Ngar_c27220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2701"/>
    <dbReference type="HOGENOM" id="CLU_1096680_0_0_2"/>
    <dbReference type="OMA" id="HVYITEN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2722-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="293" mass="31045" checksum="B1E8499313ECE041" modified="2012-11-28" version="1">MQSADPVLVTSGMDEKRWQGLRESGFRIFFVGLFSLVIAFIVYSRLTVPSADPLAVQAQQLSNLAYAVLAITAASMASMLYGVYTIFRAEQMRTAGSDSLISFITGAFANRTYWKIMAVAAIGYGVFFGFLSQILVYRPDVSLTERGVEVSSVDLTLCCAAPGYMPMFTVYITDHFLILIIPLNVILATVVSGLVGFNVALSIFAYRLKKAMRATTSLAGGVGATCGLFVGCPTCAGSLFSALIGVGVAGAGTSASVLAPFQTLFIAASIPALVIAPFLIARSIRSVSNCRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK82</accession>
    <name>K0IK82_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ordered locus">Ngar_c17640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17640"/>
    <dbReference type="EnsemblBacteria" id="AFU58697">
        <property type="protein sequence ID" value="AFU58697"/>
        <property type="gene ID" value="Ngar_c17640"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17640"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1739"/>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_2"/>
    <dbReference type="OMA" id="PFGRYVM"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFU58697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="559" mass="59759" checksum="600E09D7B5031F5E" modified="2012-11-28" version="1">MELQSRKAIEGPARAPHRAMYKAMGLTNEDLDRPLIGVSSTCNEATPCNIHLGQLAQSAKRGVKDAGCTPREFTAIAVSDGIAMGHEGMKASLVSREIIADSIEVMVRAHQYDGVVGISGCDKSLPGTLMGMGRLNLPAIFVYGGTIMPGVWNGKQVTVQDVYEAVGAYDAGKMTLQELLSLEDVACPAAGSCAGMYTANTMASISEAIGMSLPGSASPPAESERRHEICYNTGKAIMNLLENNIRPRDIMTFEAFENAIMMANAIGGSTNAVLHLLAIAREVGVKLTLSDFERIRKRTPHIADMRPGGMYVMLDLDKVGGVPVILNSLLKKGLLHGDIMTVTGKTMKENLESMTFNYGPDAKVVRHLDNPIKIEGTLKILKGTLAPDGAVVKLAGVQSKRFVGRARVFDAEEKAFDAISKRKIVEGDVVVIRYEGPKGGPGMREMLAVTAALVGQGLGEKVAMVTDGRFSGATRGFMIGHVAPEAMVGGPIALVKEGDEIVIDTSKSRIDLRVSKAELKKRMKKWKPIRPHYKTGALAKYASLVQSASEGAVTLPVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKQ6</accession>
    <name>K0IKQ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c29900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59908">
        <property type="protein sequence ID" value="AFU59908"/>
        <property type="gene ID" value="Ngar_c29900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29900"/>
    <dbReference type="HOGENOM" id="CLU_3003269_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2990-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="56" mass="6014" checksum="F1137EDBED48A99A" modified="2012-11-28" version="1">MYQSTIEVVAGKPLAYPSTQAFSIIVLTAAMLAVVSIALSVYLKRRLSSMSIPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKS0</accession>
    <name>K0IKS0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59938">
        <property type="protein sequence ID" value="AFU59938"/>
        <property type="gene ID" value="Ngar_c30220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30220"/>
    <dbReference type="HOGENOM" id="CLU_2165139_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3022-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13951" checksum="1D73BF59470E80E2" modified="2012-11-28" version="1">MVQIGSLRILIHIDMKARCGHHESNSYAEAHHGLCRKCHSNFAYIVELEEKYGEDALVEYWYSQILANLSDSKDAGCLIDHLIDFYQRKLAEVPSRQRYITKMLYMLRSVKDPFDASKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKU0</accession>
    <name>K0IKU0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ordered locus">Ngar_c30720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 8 10"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30720"/>
    <dbReference type="EnsemblBacteria" id="AFU59988">
        <property type="protein sequence ID" value="AFU59988"/>
        <property type="gene ID" value="Ngar_c30720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3044"/>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_2"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="24566" checksum="85C788F92CB43D07" modified="2012-11-28" version="1">MKVIAAVDIMGGSVVRLVKGDPANKTVYSSDPVETAKKWEAEGADMLHIVDLDAAFASGSSNFELVASIATAVKIPVQVAGGIRTIEKAEEMLAKASRVVIGTMAYSEPETVKRLAKKNPGRVVVSIDQIDGKVMVKGWKESTGITVADAISRFSEMSIDEFLLTSIERDGTLEGPDVRILAEAAKSARIIASGGIASLEDIVKVRSAGCSSVILGKAMYDGRVSIEKVKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL34</accession>
    <name>K0IL34_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c32120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60128">
        <property type="protein sequence ID" value="AFU60128"/>
        <property type="gene ID" value="Ngar_c32120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32120"/>
    <dbReference type="HOGENOM" id="CLU_2327347_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3212-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11442" checksum="8DCCCC5D960D5F9D" modified="2012-11-28" version="1">MSASRTFEVQISVLCKHWNDEKLRRQWLKDEFTVRKATANNSMRITWKDDTNVEVYFCSKGASTSQVAVQHSKLARLALVERTRSQWKAALERLSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL48</accession>
    <name>K0IL48_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily MFS-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c23970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59322">
        <property type="protein sequence ID" value="AFU59322"/>
        <property type="gene ID" value="Ngar_c23970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23970"/>
    <dbReference type="HOGENOM" id="CLU_040020_1_0_2"/>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2395-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="394" mass="41804" checksum="1B54A4CDE3F7ADD4" modified="2012-11-28" version="1">MEPKKDSDFSNVKHLGLVSFFTDLSSEMVFGLLPLFLTGPLGASRTLLGLVEGVAEMLGYTVRMASGVTSDRVQKRKPLVLIGYSLSAASKPFFALAGGWADAFAVRSADRVGKGIRTAPRDALISESVPEAKVARAFGLHRSLDQAGAIIGPLVAFALFPFVGFAGVFYFSLVPGSIAVVILIFFVKEKFVPSSEVKRSIAGNIRHVLAEKKLVALLVIMGMFSVGAFNFSFVLIRASDLGVADSMVVLVYAVINTAHTLIGYPAGMLADRVGKEKVLSISYGIFLASTVLMLLSTSSAHAYLLAVVYGLYIGIAETVQRAVVPKYVASHMRGTAYGLYNMVIGSSFLVANLVFGFLLDLSGMPAAALYSIVTSTVAIAGLVGFQTLTRSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH4</accession>
    <name>K0ILH4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative blue (Type 1) copper domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c25650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25650"/>
    <dbReference type="EnsemblBacteria" id="AFU59487">
        <property type="protein sequence ID" value="AFU59487"/>
        <property type="gene ID" value="Ngar_c25650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25650"/>
    <dbReference type="HOGENOM" id="CLU_978666_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2564-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="278" mass="28698" checksum="F6D97C3506E49FFB" modified="2012-11-28" version="1">MILTSGRRMAKGLAIVVITLAIGAAIIVPFFDEMFSIPPPVTQLRQPTPPPSEGEEPQPGGATTIQIPSGASVQGNPSYEPANAEVPMGSEVVWDNTDSVPHTATSGTGQNDPTSGDLFDTSIINPNEKSDSVVLEGVSEGDVIDYYCTLHPYMTAQLTIVAAGEGSSGGAQTGGEGGAAGSTINILSGSSVQGNPDFDPDGLTAKVGDKINVVNQDNVPHTVTSGTGQNDPNKGQAFDTNIIMGGQSATISLAEVEPGQYDYFCTIHPYMTGKLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILI9</accession>
    <name>K0ILI9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59507">
        <property type="protein sequence ID" value="AFU59507"/>
        <property type="gene ID" value="Ngar_c25850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25850"/>
    <dbReference type="HOGENOM" id="CLU_3194630_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2585-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="45" mass="5002" checksum="76578EA058570584" modified="2012-11-28" version="1">MPFFGRSAITAVTNIQFTLALSISAVERKQGPTFDNKLKDEPETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ6</accession>
    <name>K0ILJ6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c35500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35500"/>
    <dbReference type="EnsemblBacteria" id="AFU60463">
        <property type="protein sequence ID" value="AFU60463"/>
        <property type="gene ID" value="Ngar_c35500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35500"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3554"/>
    <dbReference type="HOGENOM" id="CLU_052344_1_0_2"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3551-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU60463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="266" mass="30327" checksum="25EF2DFD1774A1EC" modified="2012-11-28" version="1">MTNNPVAVFDSGIGSLSIIRELKREVPNEDLLYFADRAHFPYGNKSHQQLREIMVNTINYLRRYKPKLVVVASNTPSVQVLDEVRRMITDLPIIGVRPPLKEAARLTKKKHIGIMATEGTIGSKELKIQIRREVPQHILVTKFNASPIIELIEHGVHLENERRTFDIISRVLGEGVDEKMDVITLSSTHLPFVKTYLNALLPTVRFVDPAQIVAKDVRKFLKFYRMAKKSGTGKLQILVSDGKREFEKSVRAMGIREPVEEVFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILL6</accession>
    <name>K0ILL6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmk</name>
        <name evidence="6" type="ordered locus">Ngar_c02050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c02050"/>
    <dbReference type="EnsemblBacteria" id="AFU57154">
        <property type="protein sequence ID" value="AFU57154"/>
        <property type="gene ID" value="Ngar_c02050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02050"/>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_2"/>
    <dbReference type="OMA" id="FIFRDMA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="195" mass="22143" checksum="6A95A30B2A98980D" modified="2012-11-28" version="1">MVAANKFSIVISGWPAVGKTTIAAKLAEEFGLVMYNGGDILKMLAAEKGYFTGRDDWWDTAEAKKFMQERKSDPSFDKKVDKKLAEIVRKGGAVITSYTLPWLVQGEESLIKIWLRGSSENRAKRMANRDDISFAEAKKIIALRDKENKKIYHRLYGFRFGEDLTVFDYVLNTDKLPLDSLIEISKLIVRRQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILQ5</accession>
    <name>K0ILQ5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c02860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57234">
        <property type="protein sequence ID" value="AFU57234"/>
        <property type="gene ID" value="Ngar_c02860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02860"/>
    <dbReference type="HOGENOM" id="CLU_1192587_0_0_2"/>
    <dbReference type="OMA" id="TCTRREM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-286-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="207" mass="21410" checksum="6A26836E71485446" modified="2012-11-28" version="1">MLAAFNFIPALAHTEIARGDVQVVVGWGNEPPLVGQLNTIVLEVTRISDGQPITNALAQADISLTKGTTAKQLNFRPQEEPGVYAAEILPTQTGQFSLVLGGTIGGQAFDDIAKVEDVGDTSLIEFPQASGDGISQEAIRQLQAVIDDLTTQVEEANVAASEAKAAADSAAELSSTVNSAYLLGMIGIGVGVAGIVIGVAALRREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILR0</accession>
    <name>K0ILR0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide/opine/nickel ABC uptake transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c26910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26910"/>
    <dbReference type="EnsemblBacteria" id="AFU59612">
        <property type="protein sequence ID" value="AFU59612"/>
        <property type="gene ID" value="Ngar_c26910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26910"/>
    <dbReference type="HOGENOM" id="CLU_010991_0_0_2"/>
    <dbReference type="OMA" id="YNDTRYE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2691-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="942"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110231" checksum="A57199AB4EA15193" modified="2012-11-28" version="1">MSTFTGFVNPAFSQSSDEKGPYVDQVTFIWRDDENLALEEVRAGDFDLYFFRIPLEAADDAKNDPRLNVYDRTAGSQGLFVNPAPSRDGSTLNPFQFREARYALNYLIDREFVVNEILKGYGSPLVDPFGVYSPEYLNVIDIVESFGFRYNPALAESMISKVMISAGAVKEDNKWMYNGNPVAVKILIRQDDAPRKSMGELISSELEKIGFTVQKEYGDLNKANSVVYGSDPQDLQWHIYTEGFAGTAVFVRYNPIIPAQMYGPWLSRMPGALNPAYWNYKNATLDEVTQRIALFNFTSEEERNELVREAVKMGIQESVRIFVAQKTDPFVASSKIDGLVNDFGAGITSKYSLLNARPTDGSNSLDIGVKQIHQGSWNTIAGLQDTYSKDIYYSVVDLDTFRDPYTGEIIPFRTEWTDISTEGPLGTLDVPADAQMWDPTSQQWKPRGEGVKAISKVTFRPLYSNWHHGIPMDISDMMYADYFSTEWGTDLGAGDLTVDPEYTPQVSESLKLAKGTRYVAPDKIEVYVDIWHYDEKEIADSGTFFPVEPWEIMAASERLVTAGKLTYSRSEEAVRGVGWYDPIVPAHTEMIKQELQKMKSENFVPPALRDVVTVKDAIRRYDASIKWIEDHDNAVIGNGAFYLDSVNLAGGTMTIKAFRDQSYPFEVGHWSKYEAPRLADISRIDVPQSIAIGQPTTMAVDVEVAGQPSSDATVSYFVSDKDGNVVARGEAAPGVAGRFKIELTAEETSKLSPGPNQLRIFASSTEALRPDITTNTILATISATNNDNNPATNGQTSNNNNNPTLPPQQPSGCLIATAAFGSELTPQVQYLRNFRDHYILSTVSGSAFMNTFNSIYYSFSPQVADYEREQPWLQATVKAGLYPLFGILTAAERAHFVANGGEAGALASGAVASALIGAVYLWPAAVSTQLQRRFGTVTKISLVVLSLAVAFTVAGIIIAGSVQLLMASTALFVISLASISAMAAGRLVRVAYSKLSTGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILU1</accession>
    <name>K0ILU1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04020"/>
    <dbReference type="EnsemblBacteria" id="AFU57349">
        <property type="protein sequence ID" value="AFU57349"/>
        <property type="gene ID" value="Ngar_c04020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04020"/>
    <dbReference type="HOGENOM" id="CLU_082268_3_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-401-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13202" checksum="3CF0B295D37D9E6B" modified="2012-11-28" version="1">MLVNGMKRLDLIIPHERLTDINELLHKHKVGGMTFYDIKGRGRAKREPVSVGRGVMRYVPEFGFRTKIEVLVPDDKAKAIIDDVLKVISTGSASDGKIFVYDVAEAYDIGSKEKGDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILV3</accession>
    <name>K0ILV3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04320"/>
    <dbReference type="EnsemblBacteria" id="AFU57379">
        <property type="protein sequence ID" value="AFU57379"/>
        <property type="gene ID" value="Ngar_c04320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04320"/>
    <dbReference type="HOGENOM" id="CLU_204995_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-431-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7005" checksum="EF610A7EFD8D39CA" modified="2012-11-28" version="1">MTGFELARRIKDVKPDVKVIIMTASEINRLEFENVLPSTKIDGFVTKPATLKVVCVAIERCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM32</accession>
    <name>K0IM32_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59947">
        <property type="protein sequence ID" value="AFU59947"/>
        <property type="gene ID" value="Ngar_c30310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30310"/>
    <dbReference type="HOGENOM" id="CLU_009583_41_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3031-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="412" mass="47208" checksum="FC23BE10A8FB0B74" modified="2012-11-28" version="1">MVSGEYPPMKGGVSRYTHSLVQALAKKVEVAVATNIAVNNKVAQKGDIDDNFKDGNNTTTIYPLIRKGDKENSDRLLELAFRLKPDIINIQYERGLYEIDTPFHMIQNTLFGTTLDKFYRASPFPTVTTIHTVYPYKEYHKYIRQRAERKAGKLRFLPLPLRAAIRSQIMEQRYRLLLKIVQLSGGIISPARTIHDIVGRGTVIYHGAEPAILTNADYFPLSSMKREEFRKEFGLPAKEMLLLAFGYAGFYKGFDILDNLVLPKDWKLVIKQDRHERGNEHPMQVKNAINLNLGYLDDRILSMLFFACNAIIFPYKLVSISGVMFDALAHGLPFVASELEFFKEFADMGLGIVCKRDAKSFSDAIHYLDENYSQYRRSIEQFGPKLQWRNIADRHIEVYSKNISKRSATLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM50</accession>
    <name>K0IM50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureE</name>
        <name evidence="5" type="ordered locus">Ngar_c06160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06160"/>
    <dbReference type="EnsemblBacteria" id="AFU57559">
        <property type="protein sequence ID" value="AFU57559"/>
        <property type="gene ID" value="Ngar_c06160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06160"/>
    <dbReference type="HOGENOM" id="CLU_1639890_0_0_2"/>
    <dbReference type="OMA" id="GRYAKAM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="173" mass="19854" checksum="46D18DC87BAD6782" modified="2012-11-28" version="1">MITVDSIIGNIYRDKSLGKKYDEMLSKSQAESVRINRIESQRVRMRKTSNKGTDIALTLPSGTKLRHGDILLNTSNQMIVIELEPENVISLEIKKNLHDDDDHVVQIPARIGHAIGNLHRPLKLQGRTIYFPIQAESEVEMFRKIFSPLEDHLEIKSMKMVFEPDEGMDVHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM68</accession>
    <name>K0IM68_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60047">
        <property type="protein sequence ID" value="AFU60047"/>
        <property type="gene ID" value="Ngar_c31310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31310"/>
    <dbReference type="HOGENOM" id="CLU_2152489_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3131-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="112" mass="13011" checksum="C22D1457C27D9E55" modified="2012-11-28" version="1">MPNIRYVKKNIVYFKSSLDREKGTSIFIEFFRDIIAAKVQAGREMKGHMILQSISNPNESIVLTFWETKEEMDKFYSPDNKLLADLVERVKPLFETMPERSDYTLSAAVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM80</accession>
    <name>K0IM80_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06910"/>
    <dbReference type="EnsemblBacteria" id="AFU57634">
        <property type="protein sequence ID" value="AFU57634"/>
        <property type="gene ID" value="Ngar_c06910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06910"/>
    <dbReference type="HOGENOM" id="CLU_591361_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-689-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="473" mass="53611" checksum="4E7197514FD6285D" modified="2012-11-28" version="1">MNRSAGVRGDWQSFSKEAQDFVQRTEKFVEQGVNPGGYYKACWCRDASYILKDWFLSGAVDSVMQEITTIWSHQIEPKKEKIVYGRGSPEMKYLSQVANSDFEKKFEGALPTSIFRGHSEVFGKNPDIDSTALMISTTSWIFDAYLGAGLASNSDFLPGIQGRSKAPAKIQVQNPSEIIDSTVPKMLKAVEYLQSRDIDNDGLLEQDHNEDWMDSVLRAGKIVYTQACWIMGLTNLSLLLSHIKMEREASKMLQLADKTVSAVEKQLWSEEEECYIDMQESHHLGKSYKTLTQDVSLYLIATTEKTVRDRLGSEIQRQTKGDDGELLPIRRFSVDEKSLAVHAKSTLDAIKSRARKDKWPLVTEIEMKSTGPWVLNPNVYHNHTFWPWATALEMLARSRFKRYDECAALFSYMTGYDINGDLLAFCEWVNPITGKRGGAFPFRTGISTIRISITDILGQMKHLSKNTDMNVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMA1</accession>
    <name>K0IMA1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c07410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57684">
        <property type="protein sequence ID" value="AFU57684"/>
        <property type="gene ID" value="Ngar_c07410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07410"/>
    <dbReference type="HOGENOM" id="CLU_1615359_0_0_2"/>
    <dbReference type="OMA" id="EWEVEIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-739-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="164" mass="18628" checksum="0ADF3E698F6BF18F" modified="2012-11-28" version="1">MGDRPPEEVKIKLKHGEWEVEITCVESRVKQVVENVLSSLDTAKIVGPAIQGQFDELRREIESLKLRPAIVEPRSDEQKVPTKGGMTCRGLLESLWVEGYFGSERSLGEVHEELSRRGYNYDRTAVSHSLTDMVRENILTRIGTMRNYRYIQKRPPSNDAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMC7</accession>
    <name>K0IMC7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative diacylglycerol kinase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c08420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57784">
        <property type="protein sequence ID" value="AFU57784"/>
        <property type="gene ID" value="Ngar_c08420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08420"/>
    <dbReference type="HOGENOM" id="CLU_2930308_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-840-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="60" mass="6637" checksum="ACD32439ADD03282" modified="2012-11-28" version="1">MIVNPNSCSGLTGKNWDQLYSQIKKVLGKSSIKVAFSKKAGDGTSLARGYLRKALQRYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IME1</accession>
    <name>K0IME1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly-beta-hydroxybutyrate polymerase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phbC4</name>
        <name evidence="2" type="ordered locus">Ngar_c32720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32720"/>
    <dbReference type="EnsemblBacteria" id="AFU60187">
        <property type="protein sequence ID" value="AFU60187"/>
        <property type="gene ID" value="Ngar_c32720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32720"/>
    <dbReference type="HOGENOM" id="CLU_035017_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="167"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="441" mass="50263" checksum="01908785B1032853" modified="2012-11-28" version="1">MDREFTPIDNLQKAITANNSMIFHYWLVYASASMKPSSYVTDSLPFYFHRWLSQSDIESNRYLRSESFLDSLIGFTKSVATLYSTTNAICFPAITAITHLHRDIGAMQGSLLELQETPHEVVYQMDDVKLLHYYDLQQNRSTKKYPVPLLIVYAPVNRYHIMDIRKGRSIVEQFVSAGFDVYLLDWGAQLNNKPSVSGYVGYIHRAVDLIKKASHSEQVSILGYSWGGVLSMIYSSLRGTDVRNLILQSAHVDFHKDSSILASWFRKLPVDDIARAFDTIDCHFINFALIMRNPAVHSFDALRFAADMNSWTPSMKFGLDTMRIIAWLNDTPLIPAGFFRDYISKLYQQNQLVKNKLEIALPDGKLETVDLARITMPLLNIVGDLDDICTPPASIPINDIATSKDKKLLRYPTGHIELSVSSAVHKELWPQVVKWLEQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMI1</accession>
    <name>K0IMI1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57914">
        <property type="protein sequence ID" value="AFU57914"/>
        <property type="gene ID" value="Ngar_c09720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09720"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.926"/>
    <dbReference type="HOGENOM" id="CLU_175266_0_0_2"/>
    <dbReference type="OMA" id="VCLVCNN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-970-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="11635" checksum="75C5AB5E5CFB936F" modified="2012-11-28" version="1">MNPDTKRFLSVQMMWIGISIAISLTLSFLLPFPISLVAIIGVFIAMNYYMRRRQMRRMGMGMAGGFGGIFGAGSGGGGVNYVCMACGQRFKGGSCPRCGSKMRRADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IML8</accession>
    <name>K0IML8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c34830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60397">
        <property type="protein sequence ID" value="AFU60397"/>
        <property type="gene ID" value="Ngar_c34830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34830"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3484"/>
    <dbReference type="HOGENOM" id="CLU_120314_0_0_2"/>
    <dbReference type="OMA" id="DIMMFSM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3484-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="20319" checksum="F66513555BDD4077" modified="2012-11-28" version="1">MSENIKVTESPRHFMVLDAISRDIEDAGKIAKVTKIDKVEVEMILNDLAVQRLVVAEQKKGLFGKKVQARITDTGRRLLSSKKQELEEKAAELKGMYRNGDRRGMESFMDDNRAWLPMMLFSGIISAMIFASMMSFMGMTMNPAEAAMAGDAANADAQGAADAGADSGSADSAGFDAGGGGDFGGDFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMP1</accession>
    <name>K0IMP1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35390"/>
    <dbReference type="EnsemblBacteria" id="AFU60452">
        <property type="protein sequence ID" value="AFU60452"/>
        <property type="gene ID" value="Ngar_c35390"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35390"/>
    <dbReference type="HOGENOM" id="CLU_046006_10_7_2"/>
    <dbReference type="OMA" id="ISDHEWG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3540-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12681">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14927" checksum="6BB621E2C8E6C9FD" modified="2012-11-28" version="1">MFHKIGAVILLVSDMKRSTKFYRDTLGMKLKQQSKDWTEFSEGGTVLALHPSSKKRIKKNNSMLVGFSISDFDDVVSSLKKKKVKFYKKPKEEPFGKHAIIQDPDGHLISIVQMPQEELAQIPYYHGFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT3</accession>
    <name>K0IMT3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase</fullName>
            <ecNumber evidence="4">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cofG</name>
        <name evidence="11" type="ordered locus">Ngar_c12340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.32" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12340"/>
    <dbReference type="EnsemblBacteria" id="AFU58174">
        <property type="protein sequence ID" value="AFU58174"/>
        <property type="gene ID" value="Ngar_c12340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12340"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1184"/>
    <dbReference type="HOGENOM" id="CLU_054174_0_0_2"/>
    <dbReference type="OMA" id="TTACRYT"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="52"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU58174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="392" mass="43493" checksum="A1BB50BA5F21CB8E" modified="2012-11-28" version="1">MLTNPAIAEMLNRAVESGVTKPQAHQLMTECDTDMLVAMAGRIRDRTKPGAVTYSRKVFINLVNLCRDTCTYCTYKKAPSDPLLSMMGPQQVLAVAEAGKKFRCTEALFVTGERPEQKYRQASAWLRSLGHSSTIEYIREMSELVLEKTGLLPHTNAGSMTKKEMSMLKDTNVSLGVMLETSSERLMGKGMPHENAPSKNPKVRIKTLESAGELRIPMTTGLLVGIGETQEELVDSLFVIRQLHEKYGHIQEVIMQNFAPKPETGMAQFPPAPSEYFIRAVAIARIVMPGMNVQVPPNLNPDIFGRYIDAGINDWGGISPVTIDHVNPEFPWPSIESVQKVTEGKGHRLRARLPVYPEFLKGGFITSGRLLQQISLIADSSGLVREDYYVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY1</accession>
    <name>K0IMY1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58414">
        <property type="protein sequence ID" value="AFU58414"/>
        <property type="gene ID" value="Ngar_c14780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14780"/>
    <dbReference type="HOGENOM" id="CLU_152985_0_0_2"/>
    <dbReference type="OMA" id="DAGSVEM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1476-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12398" checksum="5C7EB595FA26ABE1" modified="2012-11-28" version="1">MKRVSDIDPGRISRPPDRVKVILAEGEQKNQGFVIKRVEMRQFIERKDDWLGDYSLLTVLVETDKGTAEMKYDEGFRGPDALDSAVTMLTQYVGLASLINRALIELLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMY3</accession>
    <name>K0IMY3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14890"/>
    <dbReference type="EnsemblBacteria" id="AFU58424">
        <property type="protein sequence ID" value="AFU58424"/>
        <property type="gene ID" value="Ngar_c14890"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14890"/>
    <dbReference type="HOGENOM" id="CLU_049311_3_3_2"/>
    <dbReference type="OMA" id="GINEYRA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1487-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="237" mass="25905" checksum="804ECD6B828B2153" modified="2012-11-28" version="1">MTTGRRIVMAIGAHPDDVELGMAGTVAKHGDRGDEVHMVICSLGIGGQSGDPKIREMEAKTAAGILGAKLHILDYPVVKLNRPSAEFEQLVRKAIEEIGPDRLYTHSPFDYHQVHESVSHCVTQAAQDVRQVLFYEVIPSTNPCFIPNAYVDITRYIDLKIKSVAAHNTQGKKWYMQPNALTSLAYTRYMLGKIGVRHDGMAEAFAIKKFIVEDIAEGAQKTAARGLAGKVTTTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN03</accession>
    <name>K0IN03_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58524">
        <property type="protein sequence ID" value="AFU58524"/>
        <property type="gene ID" value="Ngar_c15910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15910"/>
    <dbReference type="HOGENOM" id="CLU_2340270_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1589-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11330" checksum="1C86E0EEEE4CDB0F" modified="2012-11-28" version="1">MESGRKGAWLFINQQKNFVDDLSIMRLCCQDFTTYPLLEKEGASNNNMALIPRSKESTAACCPYCKHPMLKLWENSKYWHRERCSTIFDEGSFINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN89</accession>
    <name>K0IN89_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c20220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58954">
        <property type="protein sequence ID" value="AFU58954"/>
        <property type="gene ID" value="Ngar_c20220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20220"/>
    <dbReference type="HOGENOM" id="CLU_196475_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2020-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="79" mass="8735" checksum="1E5BE1BEDE9F2477" modified="2012-11-28" version="1">MTYAIEHMTDKLCPVCGLKFTETSRGITVDGKPYHDKCITELRCDNCGAIMGYLARDATIEGRNPKMFCAACSKKVIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB4</accession>
    <name>K0INB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59079">
        <property type="protein sequence ID" value="AFU59079"/>
        <property type="gene ID" value="Ngar_c21490"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21490"/>
    <dbReference type="HOGENOM" id="CLU_2476123_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2147-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="87" mass="9998" checksum="D1D5AACC34F31591" modified="2012-11-28" version="1">MKSKMQLAMGIFHFLYFDMAMSSSSSYLIEQTNAAKTPQDFVKCHTAVQPFAYILRKKQIVIWAADKLAADKTFAELQLEYIERVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0INC5</accession>
    <name>K0INC5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein GcpK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gvpK</name>
        <name evidence="6" type="ordered locus">Ngar_c22040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22040"/>
    <dbReference type="EnsemblBacteria" id="AFU59134">
        <property type="protein sequence ID" value="AFU59134"/>
        <property type="gene ID" value="Ngar_c22040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22040"/>
    <dbReference type="HOGENOM" id="CLU_1727297_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="151" mass="16594" checksum="38F33C65A721C797" modified="2012-11-28" version="1">MDTSSVDSNNNNNILLALEKKPEGPDAEKLQHGLAKLVLTLVQTMTDILERQAVRRVESGTLTAEEVERLGLAFMQIRERTADIADKFGVKPEELSIRFQQQSENQRQVTIVDVVDKLIDQGTVIAGDVTLVVAGVDLATLRLLATLTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL4</accession>
    <name>K0INL4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c26580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59579">
        <property type="protein sequence ID" value="AFU59579"/>
        <property type="gene ID" value="Ngar_c26580"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26580"/>
    <dbReference type="HOGENOM" id="CLU_1418635_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2658-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="199" mass="23082" checksum="2DB76F9FECCDF3CA" modified="2012-11-28" version="1">MFISAFRDIFSMPNLVKRSSGEHVMFLYDSLDARNKAALRYINDGLKNSQLVIYASVDADNESHISMISSKIRNYRKNIDQGNLLILKLRTFYERVLAGDLEAFKDFKELVEEIVRERVASGRTGEVLIVADCADELSRNKMFDESLFVERWWQNTYLEWLEGDLKITIICPHPGSVLENELFMSHKHDISSQHSMTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0INL8</accession>
    <name>K0INL8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fumarate hydratase</fullName>
            <ecNumber evidence="3">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fumC</name>
        <name evidence="3" type="ordered locus">Ngar_c26780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26780"/>
    <dbReference type="EnsemblBacteria" id="AFU59599">
        <property type="protein sequence ID" value="AFU59599"/>
        <property type="gene ID" value="Ngar_c26780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26780"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2653"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_2"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="406"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="460" mass="49707" checksum="BA5CCACB57209141" modified="2012-11-28" version="1">MSFRTDKDSLGKIKVPSAAYYGPFTARAINQYKVTGQKAHINLIRAFVMIKRSAALANKELKALDAEKARAIVKACDEILAGKLLDQFVVEAINSGAGTAFNMNTNEVIANRALEILGKRKGSYEIISPNDHVNMSQSSNDTFPTAMHVAILLNMKETIASLDKLIASLQRKAKKFSGVVKIGRTHLMDAIPVTLGAEFEQYAFALKQARTMLVQSMDGLRYVGLGGTAVGTGANAPKGYRQLAIRNLSKISGLSLGPSDNMFYSLQSKFDVANCSSALRNLAIELNKMANDIRLMASGPTAGLAEILIPAVHAGSSIMPGKVNPSLAECLNMICFNVIGNDVSVAMAAQAGQFELNVMLPGMLKCVLDSTDMLKNFLPIFAANMVDGIEANSEKLESYIEKSPVLVTLLNPYIGYLKAAEIYKESLKTNKSIRELVLAKKLMTKEQLDSALSKKNILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM1</accession>
    <name>K0INM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26930"/>
    <dbReference type="EnsemblBacteria" id="AFU59614">
        <property type="protein sequence ID" value="AFU59614"/>
        <property type="gene ID" value="Ngar_c26930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26930"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2668"/>
    <dbReference type="HOGENOM" id="CLU_010289_0_2_2"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2693-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="230" mass="25398" checksum="73098B6FB6A50FE7" modified="2012-11-28" version="1">MYVKLAALFSGGKDSTYAIYRAKEIGHQVVCLVTMHPVADDSPLFHYPNSWVTEYLADAMQIPLIGFSVSGRAKEDELKALEGAIAQAKSLYGIEGIAYGGISSNYQKQAFEEICVRLNVAAVAPLWNIEPQKYMNDLVECGFSIIVVGVSVMGLEKEWLGRQIDKEALGRLAALAKKYGFNLTFEGGEAETLVVDCPLFRKKLQINAATTHWDGQRGIFEIRDVSLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM4</accession>
    <name>K0INM4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59629">
        <property type="protein sequence ID" value="AFU59629"/>
        <property type="gene ID" value="Ngar_c27080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27080"/>
    <dbReference type="HOGENOM" id="CLU_2875211_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2708-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7225" checksum="BB57DD94C9C1C1FE" modified="2012-11-28" version="1">MVNQKADQRTELLCDRQQVFRNLASFFDNARSQVLACLNSYTLTFTTDIESLQAPKRAAERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0INP4</accession>
    <name>K0INP4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28090"/>
    <dbReference type="EnsemblBacteria" id="AFU59729">
        <property type="protein sequence ID" value="AFU59729"/>
        <property type="gene ID" value="Ngar_c28090"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28090"/>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_2"/>
    <dbReference type="OMA" id="MGKAVCF"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2809-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="210" mass="22773" checksum="824D86906C1DAE4D" modified="2012-11-28" version="1">MVRVIDLTMRITPSIRVFPGSPQPSFIPWSRFDSHGYDSEAVFMSTHTGTHVDAPSHFAPCLASIDMVPASRLVCSAVLIKAPKGANQLIEREDFENEPVREGEVVMIATGWEKRVAKSNYMTENPGLSEQAARYLARKKVNAVAIDGPSIDAGADSKFTAHNILLPRSILVVENLCNVSKISMTRFTLVISPLKLGGATGSPARVLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0INW9</accession>
    <name>K0INW9_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31880"/>
    <dbReference type="EnsemblBacteria" id="AFU60104">
        <property type="protein sequence ID" value="AFU60104"/>
        <property type="gene ID" value="Ngar_c31880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31880"/>
    <dbReference type="HOGENOM" id="CLU_112469_1_0_2"/>
    <dbReference type="OMA" id="CGQIYWP"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3188-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="171" mass="18737" checksum="C01A7ED9D1645569" modified="2012-11-28" version="1">MALKAPSFLADAMLGSVARKLRIFGFDTLYIAHAHDDEILKMGIEQGRVILTADKELFKRVVKAGARGVLVSGASDLEDLVHILSKNGITSVDLDGIGSRCSVCNGLLEEKKPEQVKNGLPDKVAKMHREFYQCTVCNKVYWEGGHLRRIRALAKSVDSKLLLLGRTSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0INX7</accession>
    <name>K0INX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="8">3.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ahcY2</name>
        <name evidence="8" type="ordered locus">Ngar_c32280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32280"/>
    <dbReference type="EnsemblBacteria" id="AFU60144">
        <property type="protein sequence ID" value="AFU60144"/>
        <property type="gene ID" value="Ngar_c32280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32280"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3219"/>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OMA" id="QPTHLCE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="192"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="420" mass="45554" checksum="C1F1ACFAC3247101" modified="2012-11-28" version="1">MYRSKHCESMPGKIADTKLAAKGRLSHEWALRRMGIIEKIRSKNEREQPLAGLRLGICLHITKETSVLAMAAKSLGAEIAICSANPLSAQDDIAAFLYEQGMHVYAWRGETKAQYQQCIQSVLAFKPAIVTDDGGDLHAAAHCQQKARNIIVGGTEETTSGVKRLAALQAAGKLLYPVIAVNNARTKYLFDNRHGTGQSTLDGILRATDMLLAGKNVVVCGYGWVGKGVASRARGMGATVTVTEVDPVRAIEAKMDGFAVSRLSDAAPAGDVFITCTGQTGVIRKEHFLKMKDGAVLANAGHFDVEIDTGALYATARPTQVRPNVERFIVNGKRLFLLSKGRVVNLVAAEGHPPEVMALSFANQLLSILHVAKNHDKMERKVHSVPEKIDEQVARYALGAMGIKIDEMTKEQRHYQASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7A3</accession>
    <name>K0I7A3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">iscS</name>
        <name evidence="10" type="ordered locus">Ngar_c01920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c01920"/>
    <dbReference type="EnsemblBacteria" id="AFU57141">
        <property type="protein sequence ID" value="AFU57141"/>
        <property type="gene ID" value="Ngar_c01920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01920"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.192"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_2"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="6"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="393" mass="42577" checksum="B8BCA3C5C6532200" modified="2012-11-28" version="1">MATDHIYLDNAASTPVADEVMAEMLPYMKQQYGNPSSIHRFGRETTRAIQLARKRVAEMIGASPREITFTSGGTEADNLALKGTAIHARSREPEKNRIITSNIEHDAVLEPCKDLESRGFVITYLPVTGEGLVRPSDLKNALGKDVALVSIMHANNEVGTIQPIKELAGIAHQAGALFHTDAVQAAGKIPLSVKDLGVDMMSMSSHKINGPKGVGALYIRSGLKIAPIIHGGGQESELRSGTENVPGIVGFGKACELAAKRLSQYQTHVSELRDYLIERVSKEIPHSRLNGSRTSRIPNNAHFTFFGVNGEDLIIKLDENGVAASTGSACSVKKQKPSHVLKAMGFSYEEITGSLRLSLGMHNTREEIDRTVSVLSSVVKELRELSPFKGKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0I7F9</accession>
    <name>K0I7F9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Ngar_c02230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57171">
        <property type="protein sequence ID" value="AFU57171"/>
        <property type="gene ID" value="Ngar_c02230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02230"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.221"/>
    <dbReference type="HOGENOM" id="CLU_045717_5_1_2"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-223-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="196"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU57171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="307" mass="33851" checksum="2A150F4168191039" modified="2012-11-28" version="1">MVTKNSLVNNNDSTTSTSRSVQRIVNSTRTMEGEGFLVHRSFPTHFLPDFDPFMLLDEMGPMVLAPGEAKGAPDHPHRGFETVTYLLDGRFEHKDSQGHSGKLAAGDVQWMTAGAGVIHSEMPEREFVRTGGRLHGFQLWVNLPRRDKMVKPRYQDIPSAEIPVAKSPDGRVKVRVIAGEALGKQAVIETRTPIMYLHFTLEPGAEMAQPVPQDYNAFAYIVGGKGLFGVDEKPAQREQVVLFANGGDKVSIKSPSDAASPLDVLLIAGVPLKEPVARYGPFVMNTKDEIYQAIEDYRSGRMGKIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I811</accession>
    <name>K0I811_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c04670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57411">
        <property type="protein sequence ID" value="AFU57411"/>
        <property type="gene ID" value="Ngar_c04670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04670"/>
    <dbReference type="HOGENOM" id="CLU_2204190_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-465-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="107" mass="11959" checksum="FB9CDA05494D622A" modified="2012-11-28" version="1">MLESYMFPEKLKKAIQLLGDDVNWKIVELLADRGKVTWQELLDGSGAVHAKTLNFQLKELIGVGLVDRYEVGRSLEGNTGILSFDLSPWGKDIVRGLQSALNTKQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0I8X7</accession>
    <name>K0I8X7_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57711">
        <property type="protein sequence ID" value="AFU57711"/>
        <property type="gene ID" value="Ngar_c07690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07690"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-767-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11250" checksum="38B6D13BA65F9672" modified="2012-11-28" version="1">MIKYRSRTDIASQMLEAANGGTTKTKIMYKAFLSYSQLREYLSMLTDNGLLEYDKSTETFKTTEKGTRFLRIYNEMAEFVTTTEQQTTTTAAEVKGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0I9A4</accession>
    <name>K0I9A4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57916">
        <property type="protein sequence ID" value="AFU57916"/>
        <property type="gene ID" value="Ngar_c09740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09740"/>
    <dbReference type="HOGENOM" id="CLU_3323102_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-972-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="38" mass="4603" checksum="9B4B38CB2F394CFA" modified="2012-11-28" version="1">MRINSKTAIPLLPEKIIVLKRMRIRRRGRKKKEDNNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IAM1</accession>
    <name>K0IAM1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="K0IAM1"/>
    <dbReference type="STRING" id="1237085.Ngar_c14400"/>
    <dbReference type="EnsemblBacteria" id="AFU58376">
        <property type="protein sequence ID" value="AFU58376"/>
        <property type="gene ID" value="Ngar_c14400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14400"/>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_2"/>
    <dbReference type="OMA" id="VYILENC"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1438-MON"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-20694"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="261" mass="29562" checksum="BF8EFA8687EB111E" modified="2012-11-28" version="1">MTYVNGYATRYLEHGPPDGKTLILLHGIGASAERWSRVIPTLSKYFRVITPDIVGFGYSDKPTVEYTMDFFLDFFTGFLDNLDVSKAIVVGSSFGGHLATEFAIRHNRKVDKLVLVSPAGMMRTSTPTLDGYIMAALYPTYENAYRAFREMAHDPDAVTEEIVMDFVNRMRLPNAKYAFMSTLLGMRYAPKLQGRLGKIISPTLLVWGDSDRMIPVQYAKEYNEIPDSELVVIKNCGHTPYVEKPMTFNKLILKFLVRSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IBN0</accession>
    <name>K0IBN0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="14">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">nrdZ</name>
        <name evidence="16" type="ordered locus">Ngar_c00250</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="14"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00250"/>
    <dbReference type="EnsemblBacteria" id="AFU56975">
        <property type="protein sequence ID" value="AFU56975"/>
        <property type="gene ID" value="Ngar_c00250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00250"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.27"/>
    <dbReference type="HOGENOM" id="CLU_000404_2_3_2"/>
    <dbReference type="OMA" id="MMATMRC"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="12 14" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="15">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFU56975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="911" mass="102595" checksum="DE2EFC6DDCBCD2CD" modified="2012-11-28" version="1">MAGVTEFNSNSNSGTLIAKIRKRDGRIVNFEQSKISNAIYKALVATGKPDYPLAERLAAKVVQKMVQGEKSVIPSVEDVQDMVESILIEEGLSETAKAYILYRHERRKLRDEKMKILNKRDLDEVDKAFDINSLRVLAARYLLRDSNNEIIEGPKQMFERVATLVAIADVLHDPAVFNLAGGHTQSIEEAERYYAKLDDFDNKLHIGDYYLNKYHFEAMIRHYIHCAQQGQMKVSFKELLRMIAENKMAQYEEQIKTYYNLMVSRDFLPNTPTLMNAGARLGQLSACFVLDMPDDMAGIMKSSTDAAMIFKSGGGVGINYSDLRPEGDIVASTSGVASGPTSFMRIIDTITDVVKQGGKRRGANMGILEAWHPDIEKFVTAKTKPGVFENFNVSVGIWEDFWQALVNKEGNHKYTLRSPRSREPVRQIDAQQLIDLIALSAWRSAEPGVIFFDNINKYNPLINARHGPLRATNPCGEQSLYPYESCNLGSINLANFVKRKADGAYEFDWQRYEQAIRLATRFLDNIIDMNKYPVEEIKVATKETRRIGLGIMGIADLLFLLKIPYNSKDGYEFMNKLAEAVSYLSMDESVAIARARGPFPMFKDSDYVKGRIPVAGYYELPKETHTYDWDTLVEKIKKYGIRNSWTSTIAPTGTLSMIADTANGVEPVFALVYEKRVTVGRFFYTDKVFESMLKENGLYNDEILTKIANNYGSVRGLPEIPEWMQRIFVTAIDIHWTDHVMAQAVWQKWISNAIAKTINMPGDVTAEDVKCAYLLSHELGLKGVTVFRDGSRHEQVLHITGKNTGEKAFAVKPSRYIADYVSTNIKEPYVLEQMQKIFKESGVEEEKPVPKEIPLQEIPAAPKKPAPQPAVPQMAMMDADEDRCPTCNARLIITEGCNVCIECGFSGCGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IC66</accession>
    <name>K0IC66_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c01860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57135">
        <property type="protein sequence ID" value="AFU57135"/>
        <property type="gene ID" value="Ngar_c01860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c01860"/>
    <dbReference type="HOGENOM" id="CLU_2747970_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-186-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="8081" checksum="B4885E053B95CCC3" modified="2012-11-28" version="1">MSSEYEHNVGKLLAEKKERLEQLMKNPEGHRSEIAMLSLEIESLQSLFENYNLGMNVFRRAQGGRSGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICF7</accession>
    <name>K0ICF7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57255">
        <property type="protein sequence ID" value="AFU57255"/>
        <property type="gene ID" value="Ngar_c03070"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c03070"/>
    <dbReference type="HOGENOM" id="CLU_1870803_0_0_2"/>
    <dbReference type="OMA" id="YKTRIIA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-307-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="136" mass="15715" checksum="9951401663F25B2E" modified="2012-11-28" version="1">MRRKDMEREYNNLAIDVGKRKCRAAVKDSDGNILDEFFFANDLDGRTRLVEAAHKYYPCRAVLESTGNMWIKVHDALEESGIDTKVAHPYKTRIIAEARIKSDKLDARILADLLRADLIYGSYVPPKEFREKRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICG7</accession>
    <name>K0ICG7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c21410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59071">
        <property type="protein sequence ID" value="AFU59071"/>
        <property type="gene ID" value="Ngar_c21410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21410"/>
    <dbReference type="HOGENOM" id="CLU_2730546_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2139-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="71" mass="7682" checksum="97D2ED4A41A1D569" modified="2012-11-28" version="1">MKTVGIASVGRMGQLIAGLSENNIAIILEVSIALIFMRWVQMELTKTEQMIADAAVIKAVKEIEPVLAAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ICS6</accession>
    <name>K0ICS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59166">
        <property type="protein sequence ID" value="AFU59166"/>
        <property type="gene ID" value="Ngar_c22360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22360"/>
    <dbReference type="HOGENOM" id="CLU_1821076_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2234-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="141" mass="15816" checksum="79FF9874E86BB892" modified="2012-11-28" version="1">MEEREYFRELCMGVLQADRNIRFAGVIDDTGKLLVGEYRKDIESPLIKASRLKENVVDSNGISNSSLAGITNGTFLASRMIFALNKQFEGDLGHLNYQLTEYGKVKLLTIALSNENNYYLCVSIDPVKNCHPVVLKVLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDC3</accession>
    <name>K0IDC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59396">
        <property type="protein sequence ID" value="AFU59396"/>
        <property type="gene ID" value="Ngar_c24720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24720"/>
    <dbReference type="HOGENOM" id="CLU_2857213_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2470-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="64" mass="6798" checksum="9E92D1295E791DE4" modified="2012-11-28" version="1">MGAILAAILIGILVLAIIGLGWQKFFSGIASGARQVVDNPLVEEAKEYLGGFAGQKDIPKRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDE3</accession>
    <name>K0IDE3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c24940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59416">
        <property type="protein sequence ID" value="AFU59416"/>
        <property type="gene ID" value="Ngar_c24940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24940"/>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2492-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="111" mass="12727" checksum="8FC31FACE9032F6B" modified="2012-11-28" version="1">MSENMADGDLDLGIWGMLGKRWTWPILKSIGSKEAARFCEIKRALAGISSTVLSERLLELEHEGLIAKTRDSSKVEYRLTASARELEFMLTKLDRWWSAHRKECQPVIAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDG9</accession>
    <name>K0IDG9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-directed RNA polymerase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoL</name>
        <name evidence="4" type="ordered locus">Ngar_c25280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25280"/>
    <dbReference type="EnsemblBacteria" id="AFU59451">
        <property type="protein sequence ID" value="AFU59451"/>
        <property type="gene ID" value="Ngar_c25280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25280"/>
    <dbReference type="HOGENOM" id="CLU_090381_5_0_2"/>
    <dbReference type="OMA" id="WMRINSS"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="92" mass="10605" checksum="FA817AD2C8619941" modified="2012-11-28" version="1">MLAEIVDVKDNAIELKIREEDISILYIIQHELLKEKSVDFAGVIQKHPLTKEYQMRVVTKRKDPMEVIQDTSSSAQEYSKDVVSMIKSALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDQ0</accession>
    <name>K0IDQ0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25990"/>
    <dbReference type="EnsemblBacteria" id="AFU59521">
        <property type="protein sequence ID" value="AFU59521"/>
        <property type="gene ID" value="Ngar_c25990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25990"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2599-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="15076" checksum="E946CA59CE5E4886" modified="2012-11-28" version="1">MQSGRNSIMVLDDESELVTLFSTMLKKNGYDVAGFTSPIEASEDFKFNHDRYALVISDIRMHQMNGFEIVRNVRSVDDKIKVILMTAFEVQKQEFEKVFPKTKVDEFIEKPIPLSKLVQIVSKYAGTMQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE82</accession>
    <name>K0IE82_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-formaminoimidazole-4-carboxamide-1-(Beta)-D-ribofuranosyl 5'-monophosphate ligase</fullName>
            <ecNumber evidence="5">6.3.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purP2</name>
        <name evidence="5" type="ordered locus">Ngar_c27450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27450"/>
    <dbReference type="EnsemblBacteria" id="AFU59666">
        <property type="protein sequence ID" value="AFU59666"/>
        <property type="gene ID" value="Ngar_c27450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27450"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2721"/>
    <dbReference type="HOGENOM" id="CLU_065084_0_0_2"/>
    <dbReference type="OMA" id="PEYTVCG"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="PTHR38147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004602">
        <property type="entry name" value="ATPgrasp_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1246" evidence="3">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1297" evidence="4">
        <location>
            <begin position="179"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="366" mass="41740" checksum="E72612D735A0249D" modified="2012-11-28" version="1">MIGLQQIASIVDRYDPKNVTVGTIGSHSALEVMDGAKDEGMKTVCICQKGRDLPYRRFKRLADEIILLDKFSDIMNRENQERLRELNTIMVAHRAFTAYLGYDNIENNLKVPIFGNRSLLRAEERTAPRNQYYLLEKAGIRHPKLYRKSSDIDGPAMIKVQEAKRKLERAFFIVSSYEDYKKKSKQKIEQGLVTKQDLDKATIEEYVPGTYFNLNYFVSPLTGETEFLGIERRLQTNVHDFVSLPARQQIEMDLPQPSNIEVGHTPASIRESLLEKVFEMGDKFAVAVRKEYPPGVIGPISLQSVVTTDLDFVVYDVSLRVPGNPIMATTSPYTKYYYGHTMGVGRRIAMEIKDAAAQRKLRDIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEJ4</accession>
    <name>K0IEJ4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c02400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57188">
        <property type="protein sequence ID" value="AFU57188"/>
        <property type="gene ID" value="Ngar_c02400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c02400"/>
    <dbReference type="HOGENOM" id="CLU_1811511_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-240-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="142" mass="15723" checksum="955E80F3633498D7" modified="2012-11-28" version="1">MSSPVDRNCLSYDIAIERAKNKLKQLVAPPNTQLVNEYAALMRKEFDAIEQFVYNNKTPPEDIEKLDDALKAKYGIDPDADLSSYVGDKLHIIVKAGRELNICPCCDGLKAHIIPERTSASGNSFKEESYDCQTCHGTGTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IEQ8</accession>
    <name>K0IEQ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59841">
        <property type="protein sequence ID" value="AFU59841"/>
        <property type="gene ID" value="Ngar_c29230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29230"/>
    <dbReference type="HOGENOM" id="CLU_3094235_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2923-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="6106" checksum="E41A590A91F510E1" modified="2012-11-28" version="1">MSREKRFKNTFAPWVENKWLTVEMLIGMVKIGFPWEKMPHDAQIAILEAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IES7</accession>
    <name>K0IES7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c13270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58265">
        <property type="protein sequence ID" value="AFU58265"/>
        <property type="gene ID" value="Ngar_c13270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13270"/>
    <dbReference type="HOGENOM" id="CLU_2730545_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1325-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8502" checksum="BEB66C75A4C147BA" modified="2012-11-28" version="1">MDSAITYVHEFLSPLKLKYSYCRWCDKRSPHICFLCGYCYSCHPKVESLERKKVPANIDMNRLTDIESLPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF25</accession>
    <name>K0IF25_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59961">
        <property type="protein sequence ID" value="AFU59961"/>
        <property type="gene ID" value="Ngar_c30450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30450"/>
    <dbReference type="HOGENOM" id="CLU_2299432_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3045-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="10817" checksum="C031B2325244D50E" modified="2012-11-28" version="1">MNDFNQGFLQTTSTNYNIFKDIHINVRGVGGFDISLETDCNDNLLEFVRVQSSDDGNVTGFLMKGFSNTLMKCTVEGGTTDPSIGLDVAAITHDTVCIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF50</accession>
    <name>K0IF50_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59991">
        <property type="protein sequence ID" value="AFU59991"/>
        <property type="gene ID" value="Ngar_c30750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30750"/>
    <dbReference type="HOGENOM" id="CLU_2712975_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3075-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="72" mass="8776" checksum="0FC07CDC1774E3EB" modified="2012-11-28" version="1">MSYCGLNNVKHKPIIDELVEKGLIIRFEESWGEQNRIIKYRVSEKGKERSPEQYSSHMNYCFQGERKRYEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>K0IF67</accession>
    <name>K0IF67_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c15000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58435">
        <property type="protein sequence ID" value="AFU58435"/>
        <property type="gene ID" value="Ngar_c15000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15000"/>
    <dbReference type="HOGENOM" id="CLU_688149_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1498-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="400" mass="45349" checksum="BE10E45F6CBDD2EA" modified="2012-11-28" version="1">MANLDSQRADNGTQEKEANRPSLAADAASKAVKQDDDTITIVNHKDTVRSFIEKSPLATQFAIIVLFYLAKEYMNSSKSLSSNRTDANISAAILEPFSFTSKEFFDTYSQLALEMGLIKYLVRHIAFAEFMLTLEYLVLIREEESTARYQFKVNFEDLRWMASIALQQIVGGQNLSSPEIFYPSPPRTTRPPDNNTPQPDKTIINPLTQNNTDRTAALVKDIAQSILAKNELEQSGGGTGRSIDDAVRLRSKDYGRYRPYFQHRVPPTQYSFRLPNKDEVKRIYQEFVENQTCIECGEKIVLDYFDVWIGEPLEANTRPEISDQRMTEVLGSITQERSDTTIQETISHDYHPTDRELLSFNYGIIPMDGRDAFIAFAKPKLLCSKCGANPANSVSLMPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFJ0</accession>
    <name>K0IFJ0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease V</fullName>
            <ecNumber evidence="2">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Deoxyribonuclease V</fullName>
            <shortName evidence="2">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">nfi</name>
        <name evidence="3" type="ordered locus">Ngar_c32150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32150"/>
    <dbReference type="EnsemblBacteria" id="AFU60131">
        <property type="protein sequence ID" value="AFU60131"/>
        <property type="gene ID" value="Ngar_c32150"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32150"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3203"/>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_2"/>
    <dbReference type="OMA" id="VKVGKYY"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="203" mass="22111" checksum="5E0124D23E47504A" modified="2012-11-28" version="1">MTTTYADAIKLQKEVAKKVVAKDDFGEINRICGVDVAYSGDTAYCSAVVMDRNLQLLESVHAETVATHPYVSGLLMLREAEPIFHVLKKLKSVDYDLLMVDAHGQLHPRKCGLACYVGVTLDKPTIGVAKSHLCGTARPDGFVELGGEVLGCVIGKKKRLYVSVGHRVSLETAVAIVKELGIEPLRLADINSKAQKRRKGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFR4</accession>
    <name>K0IFR4_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ordered locus">Ngar_c17220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17220"/>
    <dbReference type="EnsemblBacteria" id="AFU58655">
        <property type="protein sequence ID" value="AFU58655"/>
        <property type="gene ID" value="Ngar_c17220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1696"/>
    <dbReference type="HOGENOM" id="CLU_011534_0_2_2"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="91"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="368" mass="40837" checksum="E148CAA43017C343" modified="2012-11-28" version="1">MIAHEARRMSLKVIVLDPTEGCPASGVADEQIVADFKDENAIMKLAEKCDILTYEIELANSAALKELEAKSYPVRPAPETLRIIQNKYRQKSFLKDHKIAVPDFALVRSEEHLHELCEQFGFPAMLKACEDSYDGRGNFLITSKNKMHEAFNYFAGRECMLEKFVPFTKEISIMVARNPSGQIESFPVAENIHKNSILDTTIVPARIDRKVELKAKKMAERTMQVLHGAGIFGIEMFVTKKGDVLVNEIAPRPHNSGHYTNEACSVSQFEQHLRAVLDLPLSKPELLSPAVMINILGAENSNGPYAVKGLTKMLRVPGAKLYIYGKKTAKPQRKLGHITATGRTVKEALARAAKARKAVELIPTGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFS6</accession>
    <name>K0IFS6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c33160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60231">
        <property type="protein sequence ID" value="AFU60231"/>
        <property type="gene ID" value="Ngar_c33160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33160"/>
    <dbReference type="HOGENOM" id="CLU_2662490_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3316-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="75" mass="8408" checksum="7FA29F2865910D5E" modified="2012-11-28" version="1">MKIRAKLTLVIISLIIASLVIPSTMALESFSQGLESQITQNLEQKGIATTDKISRFMFERYGMVILSYLQILETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IFZ6</accession>
    <name>K0IFZ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57728">
        <property type="protein sequence ID" value="AFU57728"/>
        <property type="gene ID" value="Ngar_c07860"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c07860"/>
    <dbReference type="HOGENOM" id="CLU_3075471_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-784-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6029" checksum="CE0E20C9205C0A22" modified="2012-11-28" version="1">MEPIESAMWVALGFFPTLAALVAISKARIFRIRKYGRIAKIEVRRPRLREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGC1</accession>
    <name>K0IGC1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60451">
        <property type="protein sequence ID" value="AFU60451"/>
        <property type="gene ID" value="Ngar_c35380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35380"/>
    <dbReference type="HOGENOM" id="CLU_1340767_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3539-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="191" mass="21551" checksum="DB197529596C26ED" modified="2012-11-28" version="1">MIVLDSYMAMVLPDDIATRISEFIAGRRSFPIVGRDELMCMMYLYGKTGGVIGEKQVEEVNGFAQRTASQLGQEIDIYANSSAKLDPEYIRGKYINRQLQLTVENKPERMAGDPAILSDCFAQHIAYYKQDYFFELYGPLKDSEITSDIRPMLAGRMVMVCCNRKGAQETGLAHPLIPVYVWFRDQAGANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGE2</accession>
    <name>K0IGE2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c19380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19380"/>
    <dbReference type="EnsemblBacteria" id="AFU58870">
        <property type="protein sequence ID" value="AFU58870"/>
        <property type="gene ID" value="Ngar_c19380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19380"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1918"/>
    <dbReference type="HOGENOM" id="CLU_051789_0_0_2"/>
    <dbReference type="OMA" id="EARYSTN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1936-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="471" mass="53352" checksum="4059B474BECAA001" modified="2012-11-28" version="1">MGRAEKGDSIDGKTGRKKKGRGKYRKLLQHEDVRRWYDNLCRGSKVTADVYLRRLGLISETTGITLQEIVKKAAQDERWAYNFLLDFVTRMEGQNHAGSYIASGVKAVKSWLSHNGIELKRKIKIRGVGDAPTLKDKGTLAQDRLRTLFLNSPPEARCVESLIAQSGLRPEVIGNYDGSDGLRVGDILEIKVRNGDGNGNSNTIAFDRIPCMLVVRKELSKAGHQYFTFMTSETCEYLREYLYRRIKSGEVLVPDSPLIVPEKSRRPFLTAASVGKIARTYMRKVGINLRPYDLRHTFATQLMLAESRGMILRDYRTFFMGHKGDIENRYTTNKHSLPETVIDDMRKAFARSASFLQSNSSLNSDGVLNLRDESYKRMLLLAGYTEEEIDKENILRLSDEEIAKRAREKLLQSVSNAAAVQNNEQKVIPLDELPDYLSKGWKCDHIIESRQQVIVSCAGHTQTDHQLTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGE7</accession>
    <name>K0IGE7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c19430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19430"/>
    <dbReference type="EnsemblBacteria" id="AFU58875">
        <property type="protein sequence ID" value="AFU58875"/>
        <property type="gene ID" value="Ngar_c19430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19430"/>
    <dbReference type="HOGENOM" id="CLU_623515_0_0_2"/>
    <dbReference type="OMA" id="TIHFANE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1941-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="122"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="439" mass="49099" checksum="A32DEBDDBE2C629E" modified="2012-11-28" version="1">MVDYLEGDAVDHEPNLLFDKFDSSAIHHQVYWGLRKFGPYEKSKSRIKLAIIAPKDKLIQTKSIVSDLQSGSISILPGGMKSFFRCELELVDERVIDKPTGDAYSKIANEFVAASNPSNLDLVLVNIPKTGQYILDSPYYKVKGTLASAGFVTQMVTEATFANLKWSYLNLASGIFSKAGAIPWVLHSPMQNTDMILGISKSNILPPDEGPSQMKRYVGHVNVFDNNGKWMTFESNAEPYNPKEKKEISTKLGELVGRAAAKFRAMKKYEPKKIVLHNSKRFGKEDREAIIASLRANLSDFNVAFVTIDESHPFRLYDMSTDDGSFPRGYFAYLDRNDALLSTTGQSAAGGRRIGTPKILHISLYQPLSEFITMEEVVNQVVGLTKLDWATSMAFVREPVTIHFANEVAYLTAALTYSQWRSINGPAINSILNQRPWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGF5</accession>
    <name>K0IGF5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase, IS605 OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c09710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09710"/>
    <dbReference type="EnsemblBacteria" id="AFU57913">
        <property type="protein sequence ID" value="AFU57913"/>
        <property type="gene ID" value="Ngar_c09710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09710"/>
    <dbReference type="HOGENOM" id="CLU_032903_10_4_2"/>
    <dbReference type="OMA" id="NGSEMDL"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-969-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="62" mass="6827" checksum="B4865D1402C4CFAB" modified="2012-11-28" version="1">MLQYKANRVVVEVEPSYTSINCSRCGHPVPKSLAVRIHVCTKCGAILDRDYNASLITSSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGK4</accession>
    <name>K0IGK4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58940">
        <property type="protein sequence ID" value="AFU58940"/>
        <property type="gene ID" value="Ngar_c20080"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20080"/>
    <dbReference type="HOGENOM" id="CLU_1782543_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2006-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="145" mass="16142" checksum="DA1ED6DF02A84E89" modified="2012-11-28" version="1">MWSQNIILRKGRHSLAFVGIAVATIVAAFLFQRLTIYGDAVVSVYQDFYVQDLSENHSDILNGAITIDDATLSQAPKLRELMNGSLKIKDSPYGSSVASQISIFDYNVIKTISENNPLGAERLRQSNSHVVNYDGQYYGVIIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGL3</accession>
    <name>K0IGL3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57968">
        <property type="protein sequence ID" value="AFU57968"/>
        <property type="gene ID" value="Ngar_c10260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10260"/>
    <dbReference type="HOGENOM" id="CLU_3075473_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1024-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="52" mass="6114" checksum="034B57E773520BBD" modified="2012-11-28" version="1">MHDFVFMSYYFLHKAYGRAIPPLDKSSGLLASISMILFEEQDNNSFLKHFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGL6</accession>
    <name>K0IGL6_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase II small subunit</fullName>
            <shortName evidence="12">Pol II</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Exodeoxyribonuclease small subunit</fullName>
            <ecNumber evidence="12">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">polB1</name>
        <name evidence="12" type="synonym">polB</name>
        <name evidence="14" type="ordered locus">Ngar_c00020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EC" id="3.1.11.1" evidence="12"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c00020"/>
    <dbReference type="EnsemblBacteria" id="AFU56952">
        <property type="protein sequence ID" value="AFU56952"/>
        <property type="gene ID" value="Ngar_c00020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00020"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2"/>
    <dbReference type="HOGENOM" id="CLU_027850_1_0_2"/>
    <dbReference type="OMA" id="FIGPGNH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00325">
        <property type="entry name" value="DNApol_II_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011149">
        <property type="entry name" value="Pol2_small_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="PTHR10416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000803">
        <property type="entry name" value="Arc_Pol2_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_E_B" evidence="13">
        <location>
            <begin position="303"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFU56952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="487" mass="53234" checksum="874E55018068E861" modified="2012-11-28" version="1">MSYAVSKGFQIHPDAFAMLKGLESADVLKTVQEIIKSKKPSKNAVILVEDIKGLLSPKKNDGPIEQTCTVLMDPTPKVTTGEGVEGYAALFRSRFEKTMRILAQRPDSKRISKIASVKQNSRNNNSSKFVERGEKSLHGSAGSTIVAGLLMSRRTKKNGIEIAVDDYTGILTVTAVAEDAKKQAAALAMDQMVMLELENGKGAPGLTVKNIMSPDIPDHLPNRSKSEAYAVLISDLHVGSKYFMEKEFLRFLDWLSSDDDNDIVRKIKFLCIGGDVIDGIGIFPNQDKELLMMDADKQMSHAARLLAKVPKHIKMLVIPGNHDPGRRALPQPAIPGKDLADHLYGLPNCTMLGNPAFVDLNGVKLLMFHGQSLDDVIATTPGLSYSRPAEAMKVLLKARHLAPTYGERTPVAPEQEDMMVITDVPDIFHAGHVHVTDVQSYRGTLIVNSGAWQSQTKFQQTMGITPSPGMAILVNLATLQPSIQDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGN4</accession>
    <name>K0IGN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c20530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58985">
        <property type="protein sequence ID" value="AFU58985"/>
        <property type="gene ID" value="Ngar_c20530"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c20530"/>
    <dbReference type="HOGENOM" id="CLU_117038_0_0_2"/>
    <dbReference type="OMA" id="FYHYLEN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2051-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="167" mass="17487" checksum="AF62EB95303E8395" modified="2012-11-28" version="1">MAAAVVQGAVVAGLTVFLVLGQISFIKPEVSRVMAAGGAGTWFTFGYMMYIIVGVMGVAVSALFYHYLENVLGRRIRRSAKALAWTHLVLMNVGTAAAMGLLMYAGYLGGSSMLPENVGGQGFNAGQAHEILAPFVEPISVAILVIVASVVAGGTGFLMTYRYSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR9</accession>
    <name>K0IGR9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57017">
        <property type="protein sequence ID" value="AFU57017"/>
        <property type="gene ID" value="Ngar_c00670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00670"/>
    <dbReference type="HOGENOM" id="CLU_3113188_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-67-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="50" mass="5281" checksum="6DB496EE70926821" modified="2012-11-28" version="1">MCIFPPAIQTQTDIEGVVKAHAKKEGVCLLSPTTAHPLCAGVSSTVWTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH40</accession>
    <name>K0IH40_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59180">
        <property type="protein sequence ID" value="AFU59180"/>
        <property type="gene ID" value="Ngar_c22500"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22500"/>
    <dbReference type="HOGENOM" id="CLU_2433965_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2248-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="90" mass="10160" checksum="3EB3515309CF39AE" modified="2012-11-28" version="1">MDEMAQNPSSFDKETQKAKRQQAKKSVAKWLVVLGTVLAIVLASSTYLLEPILSSQHVRYLQVTEVAIIGFFAIQLITSVSYNIYVRDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH49</accession>
    <name>K0IH49_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Ngar_c22650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015019730.1">
        <property type="nucleotide sequence ID" value="NC_018719.1"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c22650"/>
    <dbReference type="EnsemblBacteria" id="AFU59195">
        <property type="protein sequence ID" value="AFU59195"/>
        <property type="gene ID" value="Ngar_c22650"/>
    </dbReference>
    <dbReference type="GeneID" id="41597885"/>
    <dbReference type="KEGG" id="nga:Ngar_c22650"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2243"/>
    <dbReference type="HOGENOM" id="CLU_076902_11_1_2"/>
    <dbReference type="OMA" id="GYDVHMN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2263-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="PTHR10553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU59195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="76" mass="8220" checksum="54CB4079691359E2" modified="2012-11-28" version="1">MSVDMAVKVLDESLGKVVLIKLKGGKVIRGNLHGFDQHMNLLLEDSVEILEEGKSNDLGTIVVRGDNVVIISPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IH58</accession>
    <name>K0IH58_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58168">
        <property type="protein sequence ID" value="AFU58168"/>
        <property type="gene ID" value="Ngar_c12280"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12280"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1178"/>
    <dbReference type="HOGENOM" id="CLU_1773257_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1226-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="146" mass="16045" checksum="DDFEEEBF35406167" modified="2012-11-28" version="1">MPRSRPVKANEMLTAEKAAEAVKETARSVREAASAARDIVKVFRESGAVEEIANAAREAAIAARDTTVEIRDAARDVNKTVADTTDIVRETAEVAQDTAQVVAKELPKPRISRRKGRTGAVKRRTTKARRQVKLKAAKKERKGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHJ7</accession>
    <name>K0IHJ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c14420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c14420"/>
    <dbReference type="EnsemblBacteria" id="AFU58378">
        <property type="protein sequence ID" value="AFU58378"/>
        <property type="gene ID" value="Ngar_c14420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14420"/>
    <dbReference type="HOGENOM" id="CLU_2534504_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1440-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="9132" checksum="FF6F1A4A2F965352" modified="2012-11-28" version="1">MSLSECPACCSRIYEYRDGRWTEWICWRCGHYESDTPAFKAYPHLFHDIVRKNGNYFLVKYAYYGKGIVRNPEPSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS3</accession>
    <name>K0IHS3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c15650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58498">
        <property type="protein sequence ID" value="AFU58498"/>
        <property type="gene ID" value="Ngar_c15650"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c15650"/>
    <dbReference type="HOGENOM" id="CLU_2629850_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1563-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8569" checksum="95AD35C865221F7F" modified="2012-11-28" version="1">MALMENDDGYAVEGFYVRKDSIDIFVRYASRAAIGAIPVVHNVHYVKSIRTIDADTAESLTEAMQKLLKYARAMEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHT3</accession>
    <name>K0IHT3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like monooxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59500">
        <property type="protein sequence ID" value="AFU59500"/>
        <property type="gene ID" value="Ngar_c25790"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25790"/>
    <dbReference type="HOGENOM" id="CLU_027853_6_4_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2578-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="300" mass="34017" checksum="B5A632CB84976A25" modified="2012-11-28" version="1">MKFIVALWGNWHRQWQLIQRAAPEADKLGYWGFVIPDHYMWSGYPNGNSTLDTWITLTYLAAKTEKIQLGTVVTPIPLRPPSILAKMVATLDVISNGRVILGVGAGWSKTEFKGYSQWDEPNVRVDKTKEGLELILKLWQSDKGGTSSKVSFNGKYYLADNAVLDPKPVQKPHPLLMFGGLGARMLRLAGRYADICLIPPWIDREFEDAKAIVLEETRRHSRENKISFAAIPTIAFEQVQRTIMSSDKSSSQYDSRMYAKGIEQAEEYGCKYVIIPFPFESFIKSMSDFALQIMPSFVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHV5</accession>
    <name>K0IHV5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59520">
        <property type="protein sequence ID" value="AFU59520"/>
        <property type="gene ID" value="Ngar_c25980"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25980"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2598-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="91" mass="10690" checksum="B00A6D3AEAF1F519" modified="2012-11-28" version="1">MKYRSRIDIVAQMLEAANNGGATKSKIMYKAFLSYGQLKDYLTIMNEKGLLDYDKKEQLYRTTEKGRKLLKLCNKIEHFTHEQEVAELPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHY5</accession>
    <name>K0IHY5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c05940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57537">
        <property type="protein sequence ID" value="AFU57537"/>
        <property type="gene ID" value="Ngar_c05940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05940"/>
    <dbReference type="HOGENOM" id="CLU_2875201_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-592-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="7351" checksum="1447343A552B1631" modified="2012-11-28" version="1">MEELKDSGAMPRHGCVPSPWCCTETVVVDFHLYLKEIEFRFNYRNENLYPILTKMLVKAASDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0II00</accession>
    <name>K0II00_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase FAD/NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c06290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06290"/>
    <dbReference type="EnsemblBacteria" id="AFU57572">
        <property type="protein sequence ID" value="AFU57572"/>
        <property type="gene ID" value="Ngar_c06290"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06290"/>
    <dbReference type="HOGENOM" id="CLU_2490566_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-627-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="86" mass="9820" checksum="D050FFED098EB3F3" modified="2012-11-28" version="1">MIGGLWTIKNLKIIYTVTDENAVGSWSGKRGRINKEMITRHLGSDEIANAIFYICGPPAMLKAMQELLQEFQVQEERIKVKEFTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0II01</accession>
    <name>K0II01_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c06340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06340"/>
    <dbReference type="EnsemblBacteria" id="AFU57577">
        <property type="protein sequence ID" value="AFU57577"/>
        <property type="gene ID" value="Ngar_c06340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06340"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.611"/>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_2"/>
    <dbReference type="OMA" id="GHPTHKT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-632-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="208" mass="22640" checksum="3EFBB8591FBB1AA7" modified="2012-11-28" version="1">MKLSRIHDLTRTISEDMQVYPGDPRPKFEPHVTIKEDGKANVTRITLGSHTGTHVDAPWHFLQDGNGIDMEPLDKFVGEAAIIDASGKSSITAGDFSCNDIRSGDIVLIHTGTGDRPTDFAYLDVSAAKWITEHGVRCVGIDTPSVEKYGVKDAPVHKMLLASNIGIIENLVNLEQFAGSRMFFVCLPLPLKGIDGSPARAVLFDIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0II18</accession>
    <name>K0II18_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC uptake transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c26480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26480"/>
    <dbReference type="EnsemblBacteria" id="AFU59570">
        <property type="protein sequence ID" value="AFU59570"/>
        <property type="gene ID" value="Ngar_c26480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26480"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="YSLFPWR"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2648-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="279" mass="31027" checksum="E33646B9963DB0CD" modified="2012-11-28" version="1">MISSEYRQSNAALLQIKNVSKTFSYADSRQNHTVLNKVSIDIKDGEFVTIVGPSGCGKSTLLNIIAGLEDPDSGKILVKGENKTSTDPGRLVIFQEGALFPWLTVLENVEFGLKLAGIPKDEQRKAASRFIDMVQLSKFADSYIYQLSGGMKQRVAIARALAIDPDILLMDEPFAALDVQTRDMLHNELLQIHEATKKTILFVTHNINEALALGTRVIVLSPRLGNIKREFTVNLPRPRDIDSPEIALIKRQILKELEEDFQFARKGNTIAGAAQQRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0II62</accession>
    <name>K0II62_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59625">
        <property type="protein sequence ID" value="AFU59625"/>
        <property type="gene ID" value="Ngar_c27040"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27040"/>
    <dbReference type="HOGENOM" id="CLU_2313877_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2704-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="99" mass="10857" checksum="D9E07D2E2CBA9997" modified="2012-11-28" version="1">MSEQDRQYEEGAGGTEVERKDDPLKQYREKEAMTPAKIKEHEPTAVKREMTEEIVEKGQEGGNPEEAREIARSKGMAKGTAGAAETGDQYEQGAAGTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC2</accession>
    <name>K0IIC2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue copper domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c08300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08300"/>
    <dbReference type="EnsemblBacteria" id="AFU57772">
        <property type="protein sequence ID" value="AFU57772"/>
        <property type="gene ID" value="Ngar_c08300"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08300"/>
    <dbReference type="HOGENOM" id="CLU_1163827_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-828-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU57772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="238" mass="25653" checksum="3C0FBA9660815202" modified="2012-11-28" version="1">MSLIPSLGLSKTQVSGAVVAAIVAASIAIAAMGILAYIRKMEPLKTWLVVYEPASQYGGIFFYSNVIWGSLWVGLFFALRHRQSMSNLRTWLIFFLVSLGIGTGFAKASLDWSQLPTVMQLGSNGEEAAFSTGGQQIANEISIKILEGSSIQGNPAYEPTIVTASRDSVIIWVNEDAAPHTVTSGIGISDPETGNMFDSGSIGKGQKFSLPVSRLEETGTFDYYCTVHPFMKGKIIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0III8</accession>
    <name>K0III8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c19360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19360"/>
    <dbReference type="EnsemblBacteria" id="AFU58868">
        <property type="protein sequence ID" value="AFU58868"/>
        <property type="gene ID" value="Ngar_c19360"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19360"/>
    <dbReference type="HOGENOM" id="CLU_2911653_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1934-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="61" mass="7072" checksum="90AE30839224933B" modified="2012-11-28" version="1">MVLMKEENGFPRWQTRAWFLNVKKRKRLLASAENKLAAAVNIIAQYRGEKSHDIQRDSGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIJ6</accession>
    <name>K0IIJ6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c28050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59725">
        <property type="protein sequence ID" value="AFU59725"/>
        <property type="gene ID" value="Ngar_c28050"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28050"/>
    <dbReference type="HOGENOM" id="CLU_2748326_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2805-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7756" checksum="C1BF9B81B3543DF1" modified="2012-11-28" version="1">MELLHTPKSELLRLMRENSLTVDEVVFLFGSNKLAAADVRMNAPTICDKLLTIFLRQAANRATVPPMTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW3</accession>
    <name>K0IIW3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c29920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59910">
        <property type="protein sequence ID" value="AFU59910"/>
        <property type="gene ID" value="Ngar_c29920"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29920"/>
    <dbReference type="HOGENOM" id="CLU_1159088_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2992-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="239" mass="24691" checksum="CF84A95273CB9A09" modified="2012-11-28" version="1">MRLDKSAQTFSIVALLVAAVAVLPLASSPASAQMAHPDNNSSYGLGDTITSADSNGTGKSFLAVFGASLVEGAKVTGVVVESEDEVSVTVANENETGRSDPVTIVAFAGKIDMMSLMMHSMMNGSGGSYGDDSFGTTNSGGGLDYSGRDPLSDFAMEDPGVHDDLGSSKSSTELFKNIKTGSSVIQEDWTSPQTVTVTLVNNGTDSTTVPDKSDTTFVLVLVFPYTEEATGTTTGEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW9</accession>
    <name>K0IIW9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c30020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c30020"/>
    <dbReference type="EnsemblBacteria" id="AFU59920">
        <property type="protein sequence ID" value="AFU59920"/>
        <property type="gene ID" value="Ngar_c30020"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30020"/>
    <dbReference type="HOGENOM" id="CLU_920149_0_0_2"/>
    <dbReference type="OMA" id="WLVAREY"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3002-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="2">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="302" mass="33770" checksum="C53A8B92135D29FF" modified="2012-11-28" version="1">MYRRYTLEEVKRKIVDILQGAGTGLSGIELADRTGINRMTITKYLDIMHAMGLVKKKKTGNVNVWFLETGVADIEFPVNYIQVQQKLISAVMAGEEEQARRILLSVLNSDIDQVRVLTDVILPATNTIGELYSRGRVDKTERAFLLNLMMELIDLVKFNVRPSEQKANANMLAVAGSDDKVHVAKSAAVAFSVLGWDALYIGDVEEQIDPFFDIDFQRYILRVWGAKRGLMLVCIFSSGEGSLRFLSSTAKAMRGRLKGELRVAVLATPELQAVAEENSDHVAKDLLSLVQWAEREYNSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIX4</accession>
    <name>K0IIX4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c30120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59930">
        <property type="protein sequence ID" value="AFU59930"/>
        <property type="gene ID" value="Ngar_c30120"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c30120"/>
    <dbReference type="HOGENOM" id="CLU_2748327_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3012-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7531" checksum="0D1F7F61F396D422" modified="2012-11-28" version="1">MKSISKCHFDNGMGIVKCVDSGQVCSGCGTGLLADEICRFCRMNVSLMYEGRGRMEGSVHGHEGQRGECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIZ8</accession>
    <name>K0IIZ8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c11720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58112">
        <property type="protein sequence ID" value="AFU58112"/>
        <property type="gene ID" value="Ngar_c11720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c11720"/>
    <dbReference type="HOGENOM" id="CLU_1493023_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1170-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="180" mass="20349" checksum="0EBDEF57B5858789" modified="2012-11-28" version="1">MIPREKPWETWIKDDTYPIGEFGWSTQSTVFLSGGESIIEVHVGESLEIPIKAIYVHRDDGRNNPKAVTLRMRAADSCELLKLSKTLSQEELLQKAYQCESGEAYDRALFFNTANLVSFTNIHRFVRLNDRVIRTINMKVTIPLDLPVELRRTIKVMPSGSVNPATVGVASRGVFLKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ35</accession>
    <name>K0IJ35_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alcohol dehydrogenase protein</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31140"/>
    <dbReference type="EnsemblBacteria" id="AFU60030">
        <property type="protein sequence ID" value="AFU60030"/>
        <property type="gene ID" value="Ngar_c31140"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31140"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OMA" id="THIATRE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3114-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="336" mass="35943" checksum="AB88304355DD01C3" modified="2012-11-28" version="1">MKAVAFYEHGGLDVLQYRDFPDPVAAGKDTVVVDVEYCGVNHLDIWTRMGIAGKKIKLPHICGCDIVGTVKGQRVMVYPGASCRKCPQCKAGRETLCSEFAIIGGMSDWNGGYAEKVAVPARNVIKLPPVLKSETAATLAVSYLVAWNMLKANGAGRGKTILVYGATSGVGMATIQLAKALGAKKVITTVSGKEKHDFAKKLGAHHVIDRSNQNIAEEVKRIAPAGVDIVIDHVGAATWPTSISMLKQGGRMAVCGMTSGNDATVPVRMFYSKQIVMTGALLGTRAQLQELIKFVVRNKIQPVIDSIFPLQDAREAQSKMEAGLHAGKIILDCKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ52</accession>
    <name>K0IJ52_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">etfA</name>
        <name evidence="3" type="ordered locus">Ngar_c12670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12670"/>
    <dbReference type="EnsemblBacteria" id="AFU58207">
        <property type="protein sequence ID" value="AFU58207"/>
        <property type="gene ID" value="Ngar_c12670"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12670"/>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_2"/>
    <dbReference type="OMA" id="EYSTILC"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="392" mass="44036" checksum="1FA758E85205FE29" modified="2012-11-28" version="1">MKKYQHLYVIIEHEDGKPVPVSLEMLGEARRLMDGYNKKYSADEKVVAVVLGHDVRRLCEELIFYGADAVIYADSPELRYARNLIDTKVISRIATSKELAAKFSDASEFVRPRYMFFAADSIGRHLSSTVLAELESGLASDINKLVIEDLEIKHEHKTKGQPMKYERTLEMYRPDFSGFLWTTILCLDNRNPAIERDYHPQACSIIPGVFAPIERDSTRRGPIVDYVPKFDECDLRVKIINRKIVKSTVDFDSKKAIVSFGRGIKDSPEENIKLVAELARELEAEVGISLPISKKPFAVSEGTSSTYMIPDRVIGTSGRKVAPLLYVAAGISGAMQHIAGMKEAGFVVAINPDEDSPIKDECDIFIKGRMEDVIPLLLEELRKQKPAIEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ96</accession>
    <name>K0IJ96_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Ngar_c13800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c13800"/>
    <dbReference type="EnsemblBacteria" id="AFU58317">
        <property type="protein sequence ID" value="AFU58317"/>
        <property type="gene ID" value="Ngar_c13800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c13800"/>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OMA" id="TIRDSWI"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1378-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFU58317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="11900" checksum="13B42265DE2621CA" modified="2012-11-28" version="1">MYYSMAVICKKCGLPDDLCACGELDKEEARIVVRLETRRFSKTTTLIEGINPKQSDMQKIVKELKSTFACGGTAKDGFIMLQGDHRDDVKGYLVKMGFNEEAIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ97</accession>
    <name>K0IJ97_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c22380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59168">
        <property type="protein sequence ID" value="AFU59168"/>
        <property type="gene ID" value="Ngar_c22380"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22380"/>
    <dbReference type="HOGENOM" id="CLU_1902037_0_0_2"/>
    <dbReference type="OMA" id="WRILHEH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2236-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="127" mass="14716" checksum="8F237E862C44BC68" modified="2012-11-28" version="1">MIYKYFQLAKTKEIEKIEEFLYTNFTKFGDSPPYDRRDFERALMLEQLQFASISDYDFKIEDLKTEVMGGGDAAIATFVLQVTGMIVDDYSFRGTSINNKSRATVVLHKDKKGQWKMVHQHLSKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJ98</accession>
    <name>K0IJ98_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c31740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60090">
        <property type="protein sequence ID" value="AFU60090"/>
        <property type="gene ID" value="Ngar_c31740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31740"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3158"/>
    <dbReference type="HOGENOM" id="CLU_1933328_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3174-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="131" mass="14579" checksum="AE4B59C89E147584" modified="2012-11-28" version="1">MKKTKWQMRAYYLDSCNCDWGCPCQFNARPTHGNCDSVIRIHIIKGNYGSIEFARLNMAWIGSWPGPIHEGHGKISYYIDERASDDQFEALSKIITGGASGGPFAVYGSSADTVQEPRRAKIAFQARSTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJW2</accession>
    <name>K0IJW2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c25910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59513">
        <property type="protein sequence ID" value="AFU59513"/>
        <property type="gene ID" value="Ngar_c25910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25910"/>
    <dbReference type="HOGENOM" id="CLU_2613757_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2591-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="78" mass="8606" checksum="CB5C4AFC77D5BE32" modified="2012-11-28" version="1">MVDYSSAYASKGGEAYFYHFGPITRTVDDDVEECQNLAGKIEKDDGSWADDALIELGCCPTILKPFCNVNSWTISNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJY0</accession>
    <name>K0IJY0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysG</name>
        <name evidence="6" type="ordered locus">Ngar_c26110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26110"/>
    <dbReference type="EnsemblBacteria" id="AFU59533">
        <property type="protein sequence ID" value="AFU59533"/>
        <property type="gene ID" value="Ngar_c26110"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26110"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2583"/>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_2"/>
    <dbReference type="OMA" id="TRPEQEE"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="249" mass="26808" checksum="313F9A1646A1E5C9" modified="2012-11-28" version="1">MMEKKGKVFICGAGPGDPKLITLRAMELLKTCDVVLYDRLVGKEIIDQIPAGAKKIYVGRTVGDPTTHQDRTNELMVKYAKKGKSVLRLKGGDPFIFGRGAEEAEHLIRHGIKFEIIPGITSAIASPAYAGIPLTHRRYSSSVAIVTGHEGAEKDELAVRWDKLAGAVDTIVVLMGIGQLDQISRDLTRAGMKKSTKVAIVASGTTEKQKVVRGTLGTIAGIAKKADIKPPAVIVIGKVAGLENLEWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK39</accession>
    <name>K0IK39_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt-precorrin-6Y C(5,15)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiE</name>
        <name evidence="6" type="ordered locus">Ngar_c35870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35870"/>
    <dbReference type="EnsemblBacteria" id="AFU60500">
        <property type="protein sequence ID" value="AFU60500"/>
        <property type="gene ID" value="Ngar_c35870"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35870"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3595"/>
    <dbReference type="HOGENOM" id="CLU_089162_1_0_2"/>
    <dbReference type="OMA" id="HSGYQFV"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU60500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="239" mass="27039" checksum="62B9D3AE89F5D267" modified="2012-11-28" version="1">MPKKLFVIGVGPGSPAYLTDAAKEAIRKSSYIIGYRYTLSTIEGIIDRDRQQVFEVTMKTQESVYQDVYNNKMKDGEYCTVPFTGDVNFSESEVVDRLLEIFGDDNVEVIPGISSIQVAAARARVPTDKALIVTFHVTGDIEQKKKDLLDAVRQGRSVILLPRPWPADPLKHFMQSEIAKFLRQNGVNTTKLKAWVFERLTTEKETTFRGTVADLEGKEFSDLSAMVIDQTKRQTYLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK77</accession>
    <name>K0IK77_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ordered locus">Ngar_c17540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17540"/>
    <dbReference type="EnsemblBacteria" id="AFU58687">
        <property type="protein sequence ID" value="AFU58687"/>
        <property type="gene ID" value="Ngar_c17540"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17540"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1729"/>
    <dbReference type="HOGENOM" id="CLU_072551_3_1_2"/>
    <dbReference type="OMA" id="SPHWAAE"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU58687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="233" mass="25185" checksum="AE1978A72AE14CE1" modified="2012-11-28" version="1">MRGIFVTGTGTGVGKTAVSAGLVWALRRHKVNVGVMKPFATANRTFSKKYRSQDTAILAEAAGVDDPDSELNPFFYSVAASPLLAWQLRREPPTSIENALQVLQNLAKKHDFMVVEGIGGIMVPLTENESVADFAKRAGLPAIIVTTPVIGTLNHTLLTVMACKEFGINIRGIIVNKMPKKPSIAEQKAPEMIERLTGIRVLGTLPFSKSANHTIIGKILEKIIDLDSLLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK85</accession>
    <name>K0IK85_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c27270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c27270"/>
    <dbReference type="EnsemblBacteria" id="AFU59648">
        <property type="protein sequence ID" value="AFU59648"/>
        <property type="gene ID" value="Ngar_c27270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27270"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2705"/>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="OMA" id="GPAAWQW"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2727-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="213"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="503" mass="57010" checksum="0D04D57D670B99B8" modified="2012-11-28" version="1">MIKGRQYVLTADRSLMSHYRHNMLFGFIVCFPAENVPPFMFKQVFCPAVPFDKNTGKADAAPLGLRRIEAGLMQGGFDRKDIIIAHPDHINKSIGQDTKIVGLNVMDPLGVGPFPSATTQGQVVTINRVIFRDLCMKVKDLKEKYGFKVVVGGSGAWQLSFDKNIREEYGIDHLVIGEADDKIAEIYQNIIAGNAQEITFTRTNTIKDIPYIQGPTTNGLIEAMRGCGRGCDFCDPNLRMKRDFPIDRLKKEAMINLKHGITSVWLQSDEILLYGCDNSELRPNKDAVINLFKEMKSLPNVNYVGAVHLTFSSAMAEPECIRQMSQINNFGPDRWNGVQIGLETASAKLIKRHMPYKVKPFSPQEWPWIVRDGIKLLNDNYYFIANTIVIGLPGEDDDDVRETIELIKSLDGTACVVAPLLYTDYHDPNKTVTANKLTKLQWELYFRCWYLNAKTVSNWVWYGTAHFNPIVRMVAVTFTKLGLWYALRLIHRDAKRFAGVELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IK92</accession>
    <name>K0IK92_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">nop10</name>
        <name evidence="8" type="ordered locus">Ngar_c17940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17940"/>
    <dbReference type="EnsemblBacteria" id="AFU58727">
        <property type="protein sequence ID" value="AFU58727"/>
        <property type="gene ID" value="Ngar_c17940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17940"/>
    <dbReference type="HOGENOM" id="CLU_196480_1_0_2"/>
    <dbReference type="OMA" id="FRIRKCP"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6300" checksum="DEABA6E7A5D7019B" modified="2012-11-28" version="1">MKHLIRKCPSCNTYTLKHECPKCKTPTTDPHPPKYSPDDKYVRYRIADRYSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC0</accession>
    <name>K0IKC0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c18800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c18800"/>
    <dbReference type="EnsemblBacteria" id="AFU58812">
        <property type="protein sequence ID" value="AFU58812"/>
        <property type="gene ID" value="Ngar_c18800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18800"/>
    <dbReference type="HOGENOM" id="CLU_180512_0_0_2"/>
    <dbReference type="OMA" id="DEQNKEM"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1878-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="100" mass="11339" checksum="9B8CB6C56BF8E8D4" modified="2012-11-28" version="1">MQRILQAQKNITSRVPIARHSTGNNMKYPIRNLMYEKIRQAGTLTDADLMKDLSKDGVTLAESEFNKTLLDLEIYGLVRVSWVTKDKRRIELVADSGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKC3</accession>
    <name>K0IKC3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c18850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58817">
        <property type="protein sequence ID" value="AFU58817"/>
        <property type="gene ID" value="Ngar_c18850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c18850"/>
    <dbReference type="HOGENOM" id="CLU_1691591_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1883-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="155" mass="17654" checksum="313B62B2969EDA28" modified="2012-11-28" version="1">MTDFKDAEVYTVEGKRMGRIKEINARYFTAFKRGLVTDEEFRIPISAISAVENYDSATTVVRLSLKEEQLKHGYEFARAKPNSEFASGVAESERKILLEKPMIRYESPHPVEETIMAERPPPISEYLCDMCNEKFGSPGELQEHRVAQHKAPTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE7</accession>
    <name>K0IKE7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative archaeal preflagellin peptidase FlaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flaK3</name>
        <name evidence="3" type="ordered locus">Ngar_c19450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19450"/>
    <dbReference type="EnsemblBacteria" id="AFU58877">
        <property type="protein sequence ID" value="AFU58877"/>
        <property type="gene ID" value="Ngar_c19450"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19450"/>
    <dbReference type="HOGENOM" id="CLU_1127120_0_0_2"/>
    <dbReference type="OMA" id="EILCLAM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="2">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="243" mass="26836" checksum="9729A63BDF0BFA21" modified="2012-11-28" version="1">MLSILFVREILCLAMLSIGAYYDLKTREVNDRLWMVFGAAGLVLYPWEYVSGATADVQMILVSVSLTAAIAVALYRYSFFGGADAKALMAISAIMPVYYSPSTFYVHPITGIMVLTNAVLFAMAVPLYNALSNLVRVTRGGRIFEGFDEPVWRKVLACFVGAPSIGQKCHHSAIECAADEKKKFSFRLNNDEAFSKDGCHSRIPANGPVWLSQNLPFLVFLLAGFLAAMLFGDLLLTTMLRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKX7</accession>
    <name>K0IKX7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c22720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59202">
        <property type="protein sequence ID" value="AFU59202"/>
        <property type="gene ID" value="Ngar_c22720"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c22720"/>
    <dbReference type="HOGENOM" id="CLU_718905_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2270-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="384" mass="44854" checksum="D5601C92463BF8E1" modified="2012-11-28" version="1">MRPRYGTEFWVYNMTHPSEDSLAGLLEEMLMRNHDEQITILFLVCKNSIKQVIESNSSGFSNEIWRSNDSGTIFSMKIGRKPRRNSPASALGNVLIVQSSHEQIYYAITNESRKFVESILRPFFKGYYPSISGAFLSSDELEDILEQLETVTESEVLLDRMTAYRRISYQRLFLDKASNKKKARKVERKESAVFYAERPYKEAFADAIANDRWVDKIQFHLISKGELALEGYISRKGLLKARRGFLPFYTVIFPYIVEIIQKKFNLYSNRARVPSKPKPSPLVVEFDYDIFKEVIQNHRFIELMKQMKFSSISVYHSNPYVHLSLVDYLDGSSFDLWVLSPNRLTVVPQLRASEASIARLMNHIFERFREGQIKDYSEMQYARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL60</accession>
    <name>K0IL60_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59342">
        <property type="protein sequence ID" value="AFU59342"/>
        <property type="gene ID" value="Ngar_c24180"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24180"/>
    <dbReference type="HOGENOM" id="CLU_2629855_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2416-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="77" mass="8858" checksum="0464C7D4055C0E50" modified="2012-11-28" version="1">MNDATTEETQIADNPRTRVRINTEIEGEPAKILLELKQRGLVSDNTDAVNQGLLVLYDRTLRRDLARLQLRQLKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL74</accession>
    <name>K0IL74_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine protease DO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c32830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32830"/>
    <dbReference type="EnsemblBacteria" id="AFU60198">
        <property type="protein sequence ID" value="AFU60198"/>
        <property type="gene ID" value="Ngar_c32830"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32830"/>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_2"/>
    <dbReference type="OMA" id="NQQWIEV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3283-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="226"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU60198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="316" mass="33662" checksum="1941B3A3B783D828" modified="2012-11-28" version="1">MSKNNESPSSTLTSLSDAIISVAEKVSPSVVGVQTGRMFGGGSGVIWSNDGYIVTCYHVVKGFKEVQVSSQELGSAMHADVVGKDPYSDIAILKISNAKNNGKTLQPIEISDSEDLKAGQMILALANPFGEQASITKGIITSSRSSVRGRWRRTMMNNVVITDARLNPGYSGGPLVDASGKMIGLNAFYISSRGIAIRTSKVKGIVENLKSYGRVRRAYLGITSYSISIPEEVAKQAGINQDSGLMVVSVEPNSPAKKAGLLIGDVVLSLDGKQVESLHDIEQLLTQELIGKAVKLVVLRSEKLTELTIVPDDASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL75</accession>
    <name>K0IL75_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59357">
        <property type="protein sequence ID" value="AFU59357"/>
        <property type="gene ID" value="Ngar_c24330"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24330"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2403"/>
    <dbReference type="HOGENOM" id="CLU_061722_0_0_2"/>
    <dbReference type="OMA" id="VIQQGMN"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2431-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="389" mass="43269" checksum="C718B26FB4092758" modified="2012-11-28" version="1">MQKKSCGFFSRASELQRAPFINLPLHTGRAPAYLVRRMIRMSHAMSKVIIDEYGQVEFLRRLSDPLWFQAFGCVLGFDWHSSGVTTVVSGVLKQALKLDVHGISIAGGKGKKSTSAKTDILLLAENFGLSSAKIDSLLYANRMAAKVDTAAVQDGYSLYHHVILFDKCGNWAVVQQGMNAENGMARRYHWFSDNVQNFVREPHTGIISEKKNPCALDMTAAQSQENQKVCVDLAKSDTNNLKSSVYRLAARDTLDRWLGGDMVVDVVNTSGYEMPRRLDWALFKRIYDVQPGSYEELLSIPGVGGATVRALSLIAELIYGAKASWSDPVKYSFAHGGKDGVPYPIARKVYDESIRYLYGAIEGAEIEREERTDALKKLASFTTRMFPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILB4</accession>
    <name>K0ILB4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU56984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU56984">
        <property type="protein sequence ID" value="AFU56984"/>
        <property type="gene ID" value="Ngar_c00340"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00340"/>
    <dbReference type="HOGENOM" id="CLU_2821034_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-34-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU56984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="66" mass="7193" checksum="E6B88EE60C88D066" modified="2012-11-28" version="1">MMNRIFTSIRASQNIAGSPRRACKDCGQPATKDALFDVGNGIAVVERYCDQCAKVIENNSNNRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILH1</accession>
    <name>K0ILH1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA methylase N-4/N-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60413">
        <property type="protein sequence ID" value="AFU60413"/>
        <property type="gene ID" value="Ngar_c35000"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35000"/>
    <dbReference type="HOGENOM" id="CLU_2695900_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3501-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="73" mass="8129" checksum="FA79DD9D0F33DEBC" modified="2012-11-28" version="1">MSSGFNTNKLFHGDNLQILRDRIPAESVDLIYLDPPFNSKADYNILFKETTGELSTAQISGIGMKLRVNPTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILJ1</accession>
    <name>K0ILJ1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c35400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60453">
        <property type="protein sequence ID" value="AFU60453"/>
        <property type="gene ID" value="Ngar_c35400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35400"/>
    <dbReference type="HOGENOM" id="CLU_1745605_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3541-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="149" mass="17265" checksum="1878488EDC7EEB8A" modified="2012-11-28" version="1">MQDSSATPLVRFSDFLGIGYFGDNRQHIIAPIFDLQQSAERAWARVMEPQLFHAVFVEHTGKYEFIAYPVELKPDKINHILYRSFSSLDSLHKFKSSYGGRTFIKFGWHDLTKPQKFDVLAQYAMVDSVEFVKVDEIRSGTLVDQIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM2</accession>
    <name>K0ILM2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35900"/>
    <dbReference type="EnsemblBacteria" id="AFU60503">
        <property type="protein sequence ID" value="AFU60503"/>
        <property type="gene ID" value="Ngar_c35900"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35900"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3598"/>
    <dbReference type="HOGENOM" id="CLU_2340274_0_0_2"/>
    <dbReference type="OMA" id="FWMRPMD"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3591-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10718" checksum="FD57FC86C9999DDF" modified="2012-11-28" version="1">MPVAILPDISEQHCIGCALCVEICTALGPDVLRVKPVEGWKRGKAFVFYPERCISDGACIGVCPTKAIFWMRPMDYTPGQPIPLKKHGLFVKGWEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILM3</accession>
    <name>K0ILM3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26400"/>
    <dbReference type="EnsemblBacteria" id="AFU59562">
        <property type="protein sequence ID" value="AFU59562"/>
        <property type="gene ID" value="Ngar_c26400"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26400"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2614"/>
    <dbReference type="HOGENOM" id="CLU_1217618_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2640-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="227" mass="24439" checksum="5EAF7A04D2F7BED7" modified="2012-11-28" version="1">MILIGVIVSLTTSGVFTQAQKKGGQDPNKDPLIDSVAAQQGDSNDGEGSGEEEDDQNEDAAQAEDDAEDKDDEGEKEFTTSFMAENCTFDSAGRTPFFILEPNYRLVLKGVENGATKVGLTITVLDETKDVDGTEARIVEERHTENDSLVEVSSNYFAICEETNNVFYFGEDVDMYENGEIVSHEGAWLAGENNNRAGIIMPGTPLLGVVLTHIGTDSITDIGNTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILN5</accession>
    <name>K0ILN5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59582">
        <property type="protein sequence ID" value="AFU59582"/>
        <property type="gene ID" value="Ngar_c26610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26610"/>
    <dbReference type="HOGENOM" id="CLU_2985807_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2661-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="57" mass="6013" checksum="C48A291179648481" modified="2012-11-28" version="1">MAGIGMWLLLVIPAIVAFAFGAWVFYSMVIDVSERDTGDAALSRCVEGCAAPPPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0ILX0</accession>
    <name>K0ILX0_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="11">5.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glmM</name>
        <name evidence="11" type="ordered locus">Ngar_c28320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="11"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c28320"/>
    <dbReference type="EnsemblBacteria" id="AFU59752">
        <property type="protein sequence ID" value="AFU59752"/>
        <property type="gene ID" value="Ngar_c28320"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28320"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2797"/>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="155"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="260"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="388"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFU59752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="457" mass="49482" checksum="9C507A2EC56D7527" modified="2012-11-28" version="1">MQAAARQRLFGTNGVRGVYGQELTHDLVIDLCYALGTYFGRGPIVVGHDGRKSSPVLSRLVRATLNSAGLDTANAGLVPTPCLQYAAKRLGYRGGIMITASHNPPQYNGIKPTASDGVEISREDELRVEDIYYSKKFAKIDGTGRDSIDDSVISKYIDAVLLLVDADKIRQKKLTVAMDTGNGAQAAVAPLVAKKLGCKVIVINGNIDGEFPARGSEPTPDNLGVLAETVRSARADFGVAYDGDGDRSIFCDDTGAIYMGDKTGALFIRHLLAGRHKGSEVVCPINTSMILEKVAEQAGSKVVYTKVGSVEVSREMVRRRSPLGLEENGGFMYGALNEVRDGVMATALALDMLAASAVDMSFSQHIAQLPQTFQYKSKFACPSREVVDKVIQACKDHGSPKKVETLDGAKIWIDEETWVMVRPSGTEPLIRMYAESTDKSLLDSKVDEYCRLVQSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM16</accession>
    <name>K0IM16_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57504">
        <property type="protein sequence ID" value="AFU57504"/>
        <property type="gene ID" value="Ngar_c05610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c05610"/>
    <dbReference type="HOGENOM" id="CLU_3178701_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-559-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5650" checksum="5CF33D907536E2CB" modified="2012-11-28" version="1">MLNFKFRLYPTREQEARLEAVLEVNCIVYNYFILNHFRSRNDMSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM62</accession>
    <name>K0IM62_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c31160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c31160"/>
    <dbReference type="EnsemblBacteria" id="AFU60032">
        <property type="protein sequence ID" value="AFU60032"/>
        <property type="gene ID" value="Ngar_c31160"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c31160"/>
    <dbReference type="HOGENOM" id="CLU_1243058_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3116-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="26030" checksum="AA496C1A6D423344" modified="2012-11-28" version="1">MSQDSVLIIWNQKQMFDRVVKLLENAKTEVLGFFNAYVFTITTDNEVFQIPKRAARKRGVKFRYITEITNDNISYCKRQLGLVDELRHLDRIRGNFIMNDSEFIASHDISPRNPITQGFYSSMGKMLKQERYVFQTLWDNAIPAEERIDQLEMGRRHDSLDSMRIMSDQAVVKEQKKTIIDRFYVCEACRSVFIYADDAEDHKTATSHKKIAEFPFFESNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IM83</accession>
    <name>K0IM83_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF608 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c06960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c06960"/>
    <dbReference type="EnsemblBacteria" id="AFU57639">
        <property type="protein sequence ID" value="AFU57639"/>
        <property type="gene ID" value="Ngar_c06960"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c06960"/>
    <dbReference type="HOGENOM" id="CLU_1431689_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-694-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF608" evidence="1">
        <location>
            <begin position="102"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="189" mass="21088" checksum="16EDC53588D68F45" modified="2012-11-28" version="1">MKFMSEEAKEDKQKEFAGVLPTTIYQAGFSEVYDQNPDIDSTALMISTTARILNRALKKIATSPVTDPTSISTIASEHSADYVHDLLLKLGITDPTKAIDFLVPRMLLAVDYLAKRDIDSDGLLEQNHNEDWMDTVLRAGKIVYSQACWILTLKNLAALLVTVDRQDAADKIRNMADKAIQAVEDKLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMD5</accession>
    <name>K0IMD5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-pyrroline-5-carboxylate dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rocA</name>
        <name evidence="5" type="ordered locus">Ngar_c32570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32570"/>
    <dbReference type="EnsemblBacteria" id="AFU60172">
        <property type="protein sequence ID" value="AFU60172"/>
        <property type="gene ID" value="Ngar_c32570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32570"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3252"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_2"/>
    <dbReference type="OMA" id="DAWKVYM"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="53"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU60172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="523" mass="57513" checksum="2BC2BF8D864A4A1E" modified="2012-11-28" version="1">MFENEHTVRRFMAEKAEGQFHDRYERALEQVRTEFGRKYAMIIGGREVRTPATTSHVSPIDTRIVLGHLPVGSASHVKQAVAAAKKAFESWSRTNYQERVQICRSAADIMSQRKFELAAWISYENGKNRYEAIADVDEAIDFLRYYSEEMERNNGFETVMKSAQPNEKSRSVMKPYGVWGVIAPFNFPAAILVGMSTGAIITGNTVVVKPSSNTPIIACKFAEVFKQAGLPDGVFNLVIGPGGKVGGELVSNKDVSGIVFTGSRDVGYGMAQEFSKTRPKPLIAELGGKNPAIVTETADIGKAVDGVLKAAFGYSGQKCSACSRVYVHKKVKDEFVKRLVEKTRDLPVGNPLDPNTFVGPLANEDAYKKYQRYAKMADRDGKVLVGGSAIKDGELKHGYYVQPMIVTGLPKKHRLFKEELFVPILCVAHYEKFDDAIKLANESDYGLTAGIFSGKQEEIKEFLDCIEAGVVYVNRQASATTGAMVGCQPFGGWKSSGTTGRGTGGPHYLTQFMREQSQTIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMH2</accession>
    <name>K0IMH2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c09520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57894">
        <property type="protein sequence ID" value="AFU57894"/>
        <property type="gene ID" value="Ngar_c09520"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09520"/>
    <dbReference type="HOGENOM" id="CLU_152989_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-950-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="11031" checksum="278D9E1F92BA29DD" modified="2012-11-28" version="1">MDNIIRTAIASKKLIEFSYEQKHRIAEPHVYGILNGKRQLLVYQIGGQSSSGNLPNWRRMDVSKISNMQMLDDHFPGRRPYPSGEHSSFDTVLAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMT1</accession>
    <name>K0IMT1_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger C2H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c12240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58164">
        <property type="protein sequence ID" value="AFU58164"/>
        <property type="gene ID" value="Ngar_c12240"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12240"/>
    <dbReference type="HOGENOM" id="CLU_214147_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1222-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="51" mass="6153" checksum="E55CFD6B1D161103" modified="2012-11-28" version="1">MWGFSIYLIRIADYFYGRRSRKKCDVCGKKFNNIDEMEVHRRDLHPDAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMU3</accession>
    <name>K0IMU3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c12840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c12840"/>
    <dbReference type="EnsemblBacteria" id="AFU58224">
        <property type="protein sequence ID" value="AFU58224"/>
        <property type="gene ID" value="Ngar_c12840"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c12840"/>
    <dbReference type="HOGENOM" id="CLU_923221_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1282-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="301" mass="33346" checksum="FA08DD8F74B1AEDD" modified="2012-11-28" version="1">MPEIMGNVHRYFATTVGLITTKGKHGPNVMAAEWTMHVSYDPMLIAVFVHDSPTYWNIEETRVFGVNIASDDQSELVNIAGGYSGTEINKLAIPGTFSTYSAKHIDVPMIKGCALNAECRVTTIEKMGDHIMVVGEAVSAIFDEKKFPLIYTRGNYRKLSRSKIPSGRKVVRITPDQMSQFQKMSAGQFVLKAAAAVIRRQNGGQILLQKFGDWWILPMVVVNKGANYKEALEKHLGSIGVSASVSKISGIKRMTLKAGKTELRANFITFDCKLRSLEGSDAEWFTRLPKNSTVLTLLEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMX4</accession>
    <name>K0IMX4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c14430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58379">
        <property type="protein sequence ID" value="AFU58379"/>
        <property type="gene ID" value="Ngar_c14430"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14430"/>
    <dbReference type="HOGENOM" id="CLU_032903_10_3_2"/>
    <dbReference type="OMA" id="ERIFECH"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1441-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="119" mass="13525" checksum="81ED2E2E2974C0BD" modified="2012-11-28" version="1">MFEKLNINNMVKNHNPASAIMDVTWSKLRQMTAYKVERRGGQVILVNPSGTSQKCSRCGVDKEEKKLGLDERIFECHSCGLVVDRDVNAAKNILKRGLEQAYAERQPRPSTKKNKQVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN11</accession>
    <name>K0IN11_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ordered locus">Ngar_c16310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c16310"/>
    <dbReference type="EnsemblBacteria" id="AFU58564">
        <property type="protein sequence ID" value="AFU58564"/>
        <property type="gene ID" value="Ngar_c16310"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16310"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1603"/>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_2"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU58564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="433" mass="46247" checksum="9394C245172EB703" modified="2012-11-28" version="1">MVSILVRKSKIAGSVRCPSSKSYSHRAIAIASLAERQSTITNALLARDTLATLASCRALGAEIKHEGTTVQVKGRHTFEPPENVINAENSGTTIRIMTAMSGLVRTGYTVLTGDESLRKRPMQPILDALAQLGVEAHSTKGNGTPPLIVKGGGIRGGTTVIDGSISSQFISGLLIAGIYADSEIVMRIKGNLVSKPYVSATLATMKHFGVTVDHRSDMLEYQIKNARYCATKFDVPSDFSTAALILAAGALVGEKLEVKGLNFALPQGDSQIVDILKQMGCPIKIDKSKGEVVVQKAEELEGGDFNLNDTPDLLPVVSILALKAKTPVTITGVAHARVKETDRVANIASELTKFGARIKEFQDGLKITAPKPLKNASLKAYNDHRLFMAFTIASMMTEKSVVAGAESVDVSYPAFIQDMKDLGAKISPAPDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN13</accession>
    <name>K0IN13_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c16410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58574">
        <property type="protein sequence ID" value="AFU58574"/>
        <property type="gene ID" value="Ngar_c16410"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c16410"/>
    <dbReference type="HOGENOM" id="CLU_207595_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1639-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="44" mass="4945" checksum="3E0EA7E6598E39B0" modified="2012-11-28" version="1">MTRENVALTYELNNVRIAVPGSLNNRSEQAQWIIDGSITVRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN30</accession>
    <name>K0IN30_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome subunit alpha</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">psmA1</name>
        <name evidence="3" type="ordered locus">Ngar_c17260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17260"/>
    <dbReference type="EnsemblBacteria" id="AFU58659">
        <property type="protein sequence ID" value="AFU58659"/>
        <property type="gene ID" value="Ngar_c17260"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17260"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1700"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="222" mass="24328" checksum="0E89349B77D72CD4" modified="2012-11-28" version="1">MEYAIETVRRGTLAIGIKSKDGVILAVEEKARKLQISNVTQKIFQVDDHIGVAAAGYIPDARTQVDHARFFAQSNRLIYDEPVDVEGVAKNIADMAQQFTQYAGVRPFGVALILAGVDKNGSALFLTDPSGTYIGYDAVAIGAGSDQVTEFLEKSYKADISLDEGAALAIESIYLVSEEKTGTRHLKMAIIDNKTKTMRKVEDEEIERYASMARDRTSKRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN77</accession>
    <name>K0IN77_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TrwB_AAD_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c19620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58894">
        <property type="protein sequence ID" value="AFU58894"/>
        <property type="gene ID" value="Ngar_c19620"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19620"/>
    <dbReference type="HOGENOM" id="CLU_322024_0_0_2"/>
    <dbReference type="OMA" id="HENERYV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1960-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10412">
        <property type="entry name" value="TrwB_AAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwB_AAD_bind" evidence="2">
        <location>
            <begin position="54"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU58894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="899" mass="102057" checksum="495E64198404348F" modified="2012-11-28" version="1">MGLFERIRKKPDGGKEGNNQEEFDISKYVEPNTEPVYLLGVDSNTGEKKGLYKSDRGHTLIIGRTQYGKTTLIETLILEHVQEDEPFVYIDPSGDSVNKILALIPDEKRKNTILIDPMTIHTHGKVVKIDFLEYSNSLSRLKVAQGFIDAVKKLSGGMWGPLLERIMRNTILLLIDQEKGSTDITDCYYVVNNVEYRERLMRNCSNKDVVNFFVNDFGRIRPESLEPILTRLNTILVDPLVKEMFKTKRKDGAVVKTLDLRDAIDSGKFVLVNLSKARLGDMSAFIGSLLLDKIFQTAISRADERVKEKRRACYLYVDEAHTFVTDAVIDILREVAKYRLYLTLVSQYPSGFTEEIKKAVFGNCSTIITFSVGPDTAKEIAPFFAPYDTQTIMLLPRYEFMVSTKMKGMPLKPFSLSTHYKQISDSELIMRSEECMVESLCIYGQEVSSDLEDKADSSETIVIAPKNASFPRPPFFTTPLKWFIQTRLFFDRNGMTTKALFEQAVSSPHHHKPYNAGFQKVKAVLHEMVREGLVQTTQITAADSQSDEKRFTFTLTESGLKPFYEIPKGARAGGDVHLNWIDLFLHAFWRMGWYCIADNGHLSEGHSDIYAFSPKLADNGSKYDSDEWESPPAWAVEFEVYPERHPDRVIENYLRNAASGIRTVFVTDSEERKKRILQALKERSISAYVPVLLVSRAATHSNVEKVVHALTAIREPALLKQVIADAESFVSKGQEKENVRDDVEMTAEKHSRVEMTSTAISRPEVEGANMKERDPEDDDDASNTDVSGENEEQIIWGEDVERGEPSTTVMDMLYQELADDESLVKILLAVKENPGLKSSDILPKLDMPRRTFMRKSLKLKELGLISAMERVPGYTITERGMALLEEIRKGKQRWLNRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INB8</accession>
    <name>K0INB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c21690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59099">
        <property type="protein sequence ID" value="AFU59099"/>
        <property type="gene ID" value="Ngar_c21690"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c21690"/>
    <dbReference type="HOGENOM" id="CLU_2519587_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2167-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="88" mass="10081" checksum="10C579ACA9E17503" modified="2012-11-28" version="1">MESKHIIPQDKADEVKALVARYVLLRIEQKKIEAKLNEITRFYDENSLRTIFEPIGDSMMGVIGLELPRRKQSVETSVEQTTTSSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>K0INF8</accession>
    <name>K0INF8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rieske (2Fe-2S) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c23740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c23740"/>
    <dbReference type="EnsemblBacteria" id="AFU59299">
        <property type="protein sequence ID" value="AFU59299"/>
        <property type="gene ID" value="Ngar_c23740"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c23740"/>
    <dbReference type="HOGENOM" id="CLU_055690_5_3_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2372-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU59299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="14039" checksum="5E5622365BF57B80" modified="2012-11-28" version="1">MNDGYYRPVCRSDELKDDSMRVFRVDSTDVLVGRRNGKLFACNNSCPHRGASLSKGEFKDDNIVCYMHGYEYNVFTGKLENMKSWKKEETWVEQNPEWRKSGDLVLYEIKEHGGTVYVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0ING8</accession>
    <name>K0ING8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59349">
        <property type="protein sequence ID" value="AFU59349"/>
        <property type="gene ID" value="Ngar_c24250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24250"/>
    <dbReference type="HOGENOM" id="CLU_2802400_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2423-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7585" checksum="219D1CF5B267D444" modified="2012-11-28" version="1">MPEKLKWSVISLKIFLSYQLSLTQSLSPDVEMVLLTPDEINRFISTLKSRYTTGPVAKKKTARARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INI3</accession>
    <name>K0INI3_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c25010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25010"/>
    <dbReference type="EnsemblBacteria" id="AFU59424">
        <property type="protein sequence ID" value="AFU59424"/>
        <property type="gene ID" value="Ngar_c25010"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25010"/>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_2"/>
    <dbReference type="OMA" id="DWRPPIV"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2500-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="307" mass="33042" checksum="04A9B8E8FEFDE50F" modified="2012-11-28" version="1">MLPIVKGLLAGERRALARAISIVDNDEPESREIIRQIFSKIGGARTVGFTGPGGAGKSSLVGRLIPECQALGYRVAVLAVDPTSPLTGGAILGDRVRMQGNLDDEKVFMRSMASRGAVGGVSKSLRNAIRILDAAGYNLVLVESVGAGQLEIEISKVVDITAVLFTPHTGDNVQAVKAGLTEIGDMYIINKSDLEGAGALYNTIVDLIGDTDRKPVVLKASAKTGKGVRELAKSIDKLLKEKSINYKERERRMLENELRDMVLNTVEKKASQMLAGSKKYSEFVDKLTRKEIDPYAAAEELAAGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ8</accession>
    <name>K0INJ8_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Ngar_c25780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59499">
        <property type="protein sequence ID" value="AFU59499"/>
        <property type="gene ID" value="Ngar_c25780"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25780"/>
    <dbReference type="HOGENOM" id="CLU_137479_3_2_2"/>
    <dbReference type="OMA" id="MIVAEFS"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2577-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFU59499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="106" mass="11565" checksum="8492F74624F3AC8E" modified="2012-11-28" version="1">MNNLPIVDAEISIEPIGTSDTSMGKEVAAAYNAIRSIQNLKVTLTPMSTQIESDNLDDILQAIRIAHNSAKSSGVKRVISTIRIDERLDKPNTMEEKVQSVKAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ7</accession>
    <name>K0INQ7_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction response regulator, receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59794">
        <property type="protein sequence ID" value="AFU59794"/>
        <property type="gene ID" value="Ngar_c28750"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28750"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2875-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="128" mass="14509" checksum="CE57BE9997B6DA6F" modified="2012-11-28" version="1">MEKQHKLLVVDDEPDILYITVRTLQKYFLVDPFTSPIKALAHFEKHANEYTLVLSDIRMPGMSGMEFLNVVKLIRPDIPILVMTAYSASDDEIVGAIPWIAKEEIVHKPFRALEICGAVKKILKITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0INQ9</accession>
    <name>K0INQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59804">
        <property type="protein sequence ID" value="AFU59804"/>
        <property type="gene ID" value="Ngar_c28850"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28850"/>
    <dbReference type="HOGENOM" id="CLU_2875213_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2885-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="63" mass="6776" checksum="29299127A4DAA049" modified="2012-11-28" version="1">MAVTKWMPYSSVGAAISFVVGFVFSLPPAQVIVSAAMTATLIFSGLFFQSYGRDKEEQAKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ5</accession>
    <name>K0INZ5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c33190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c33190"/>
    <dbReference type="EnsemblBacteria" id="AFU60234">
        <property type="protein sequence ID" value="AFU60234"/>
        <property type="gene ID" value="Ngar_c33190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c33190"/>
    <dbReference type="HOGENOM" id="CLU_2802405_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3319-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="67" mass="7086" checksum="1AE0AD6C54F4C74B" modified="2012-11-28" version="1">MPRLFGKFVTKSVQGGTEHGTGLGLFISKAIVKAHGGEIYAHNNREGGATFTILLPIRNGQDGTGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IP20</accession>
    <name>K0IP20_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c34440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60359">
        <property type="protein sequence ID" value="AFU60359"/>
        <property type="gene ID" value="Ngar_c34440"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c34440"/>
    <dbReference type="HOGENOM" id="CLU_139543_0_0_2"/>
    <dbReference type="OMA" id="CKKRFCE"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3445-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="147" mass="16921" checksum="103C3723FE4F8E76" modified="2012-11-28" version="1">MVPCNKDIAMTTSDPTGGDKVVYFGVININENGRTMGSVDVWRSLLTKELFCEEKRLGIDQIVDYIGMPKIEKDKKWAVAISRNRKGHLRWRLVKMIKEGKLEFTDADDKAIEVNVKDYKIADPEWWSFLVEENVNRNMEVADGPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>K0IDP8</accession>
    <name>K0IDP8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase, with phosphoacceptor and ATP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Ngar_c08930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c08930"/>
    <dbReference type="EnsemblBacteria" id="AFU57835">
        <property type="protein sequence ID" value="AFU57835"/>
        <property type="gene ID" value="Ngar_c08930"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08930"/>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-891-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="407"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU57835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="649" mass="71968" checksum="E1BB0283CDDF11AF" modified="2012-11-28" version="1">MLVNYIIEFTDTIIYSITTSINQCRRLNVVRSSADTLVAIREAAKSRPTRFAIVVLALIVGFALGFSIYFQLVNEQSIKATLFEEQRIRQSQSMEARARQISSELESILGRLQGIANSNYIQEGELSGDRISTLLAENYNPVKESVRSIFILDSNDVETATTVLLDDQNYIGLLHFGKDYVAETKVKLAPVLSRSYSGVNGTSYVILSYPVIQRESGEYLGLVAAVIPLQQILSGLGGPYTTQESEHVLVTDKSGTFILADDNDLIGKHFENKEILQRLDNPDDFQNLFTQALAGQSRSIVVDGLYQNERLLVAYPANLRQQTVFVIASSTPTEGIYSKIEGIVFTQRIQTLALVGAVVASIAVILYFLARWSETLQREVKKRTKELETANKQLEAHDRMQSEFINIAAHELRTPVQPLLGIADLLHLSFEQDPHNGEIAISKADLDLIRRNAKRLERLSSDLLEVSKIESNSFKLHKEWVDLDKKIKEAIIDAKSSLRDEKKQKIQILNAQAGAPIGNSNRPLLVYCDKVRIFQVLSNLIANAIKFTEEGQITIRSEERDDGYAVINVIDSGKGIVEEMMPRLFKKFATKSDSGTGLGLYLSKKIIESHGGTIWAENNAGGKGATFSFALPIAGGGGKGGGEEEKQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IE03</accession>
    <name>K0IE03_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57990">
        <property type="protein sequence ID" value="AFU57990"/>
        <property type="gene ID" value="Ngar_c10480"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10480"/>
    <dbReference type="HOGENOM" id="CLU_2044485_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1046-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="120" mass="13518" checksum="6AD27BEFBE3DCC58" modified="2012-11-28" version="1">MTEFSKAVAGCIAEWGKRAAACNDSAECLEHSARQLRECLDAAFPDSKKVELESDKVNYMLSSIFFLANRLSKASQGLAEFDKVMSDIEKVGKASLEDGENRQLYIKFHKELDEILARYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGA2</accession>
    <name>K0IGA2_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c35230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU60436">
        <property type="protein sequence ID" value="AFU60436"/>
        <property type="gene ID" value="Ngar_c35230"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35230"/>
    <dbReference type="HOGENOM" id="CLU_1067998_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3524-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="260" mass="29134" checksum="474141C3B6ADD885" modified="2012-11-28" version="1">MYSSDRKKVGFLRKTLPEYMVVKKGLIGLSSYLIPKSLAESVDKKGIRLRITAYEARHKYSHSKMKRLAIYGQVPKSAVQQRIVYDRLQTLRYSTTRNRLAAGIAFVSGILFLLSGYRANIEIYNLIRDQLVINTARDFWTYAVIPIGFLALLSQLGGLTVLMGAGLFAANRVNIGKFLVFVGTGQGLITVLIRIALEFWSGRLALDNNYITWLTSTATGLGILFAVVASYITKGKGESVYVKAIRFILRKRSVARRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGR6</accession>
    <name>K0IGR6_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c10910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58033">
        <property type="protein sequence ID" value="AFU58033"/>
        <property type="gene ID" value="Ngar_c10910"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c10910"/>
    <dbReference type="HOGENOM" id="CLU_2748316_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1089-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU58033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="70" mass="7719" checksum="93584766F1070D89" modified="2012-11-28" version="1">MKKTGKARPLLPVIILIIIINAILLLTLLGSNPAYAKILPSNHPDIEVSARMVPEEIELEEDGSVDTEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IGV4</accession>
    <name>K0IGV4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57047">
        <property type="protein sequence ID" value="AFU57047"/>
        <property type="gene ID" value="Ngar_c00970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c00970"/>
    <dbReference type="HOGENOM" id="CLU_2327340_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-97-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU57047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="98" mass="11474" checksum="F683C517980002F0" modified="2012-11-28" version="1">MPDIIYIMSYYKLCAKSRMPLAGILANRKKSIMHGMNLRPYAKKPLLVLCYGFKIADGILRVSLDERQYFDIPLNGYVRRTLSNQSIREFLFYRAPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHQ9</accession>
    <name>K0IHQ9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative YHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c04200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04200"/>
    <dbReference type="EnsemblBacteria" id="AFU57367">
        <property type="protein sequence ID" value="AFU57367"/>
        <property type="gene ID" value="Ngar_c04200"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04200"/>
    <dbReference type="HOGENOM" id="CLU_185152_1_1_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-419-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="46" mass="5333" checksum="661FCB1734B92DF6" modified="2012-11-28" version="1">MATDPVCGMEVDEKKAPKETYQGKDYYFCCPSCQWAFQTNPFQFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0IHS5</accession>
    <name>K0IHS5_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylosuccinate lyase</fullName>
            <ecNumber evidence="5">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">purB</name>
        <name evidence="10" type="ordered locus">Ngar_c04510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ga9.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c04510"/>
    <dbReference type="EnsemblBacteria" id="AFU57397">
        <property type="protein sequence ID" value="AFU57397"/>
        <property type="gene ID" value="Ngar_c04510"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c04510"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.433"/>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_2"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="9">
        <location>
            <begin position="362"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFU57397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="451" mass="49663" checksum="B77207A4A7FEDBC5" modified="2012-11-28" version="1">MPILPIDSGRYGSKEMREIFEDEKRLQYQLDFEAAVAQAQAQIGMIPAEAAREIAKGARSSKVTLARVSELESVSEHDTAAMVEALSEQVSAKAKPWIHYGLTSNDVVDTSTCMQMRDAFSIIESKVAKLALLLSDRAVEFKAMPAVGRTHGQHASIISFGLKFAVWAAEMAKHVERIQQGSKRFLLCKTLGVVGTGSLMGDRALEVQKIVAQNLDLYPVDAATQVVPRERFAEMQFCIALIGSTLDKIAIEIRNLQRTEIGEVAEPFRKGQMGSSAVPVKRNPIKSERVSSLAKMLRALVSVSMENVALWHERDLSNSANERFTLPMAAILLDEMLNAMTKVVSELKVNVEKISSNIEMTKGQIYAEFVLEALVKKGVARFEAYRDIQRVAFAALESGDHLFDAASNDKSISKHLSKQELEAIFEAKNHLAASGKIIDSVAKMVRNVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIB8</accession>
    <name>K0IIB8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c08250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU57767">
        <property type="protein sequence ID" value="AFU57767"/>
        <property type="gene ID" value="Ngar_c08250"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c08250"/>
    <dbReference type="HOGENOM" id="CLU_2340269_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-823-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU57767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10561" checksum="4859C9CA125A4A48" modified="2012-11-28" version="1">MNEQKDGQKDMSCMQGSILHKVQRTIAFNINRLLKIGYWLSLFGILAIMIPSGLVLLSGIGANNNAYGATPDVIHYMSGPSLHNMAGEEITSLQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIC8</accession>
    <name>K0IIC8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2, subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">eif2a</name>
        <name evidence="5" type="ordered locus">Ngar_c17950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ga9.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c17950"/>
    <dbReference type="EnsemblBacteria" id="AFU58728">
        <property type="protein sequence ID" value="AFU58728"/>
        <property type="gene ID" value="Ngar_c17950"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c17950"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1774"/>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_2"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFU58728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="270" mass="30288" checksum="ECEB6D4F414FBD58" modified="2012-11-28" version="1">MTATDEVQRLPEEGEIVIATVKEVTGHGAYVTLDEYNNMTGFLHISEIATGWIRNVERYVRPKQKAVLKVIRVNKARGEVDTSLKQVSGEERKSKLIEVKKNEKATAFMDFIKSKLKLTDQQVAEIEEKILQKYDYVYDAFEAVARKGPEAIQNIDLAPEIKQAIEEESNKIQIPQVEVRGIMEISSKKPDGIEIIKNTLAGIESSKGGATTTVTYVGAPRYRIVVTAENFKVAEKSMNNAVEKIRSAIEKQHGSFNFTREESKKSHQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIL0</accession>
    <name>K0IIL0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pstS1</name>
        <name evidence="13" type="ordered locus">Ngar_c09800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PstS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU57922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c09800"/>
    <dbReference type="EnsemblBacteria" id="AFU57922">
        <property type="protein sequence ID" value="AFU57922"/>
        <property type="gene ID" value="Ngar_c09800"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c09800"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.933"/>
    <dbReference type="HOGENOM" id="CLU_379772_0_0_2"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="485"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU57922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="729" mass="78559" checksum="9F2A52558243A8CD" modified="2012-11-28" version="1">MRKRAALLAITAIVLLVPPVLTVFAQNPVTINGAGATFPYPLIDTWRTQYQSVEPSVNINYQSIGSGGGVKQFLEKTVDFGASDAPLSSSELERAQNAVHIPETIGSIVVSYNLPSVPEKGLKLTGPVIADIFLGNIRKWNDPQIQSLNSDISLPDREIIVVHRSDGSGTTFVWTDYLSKVSREWHDKIGTGKSIQWPRGIGAPGNEGVANAIKGNLFTIGYIELSYALSTGMPYAFLQNREGVFVEPSFETIQAAIESSATSLPKGDESWEEVSTTDAPGANSYPIASFSYILLYKELTDNPSIDHRKAETLVNFLLWAITDGQQYADDLGYVPLPESVVKLNQETISSLTFNGQPIVVAAGGQAGAGQIDQRLELAALAGVTTAVVTSAVYITYRRRKSRFGSITSRKDISSFLVKGSPRGDRVFRFIAVATAGYTLFLIVLVAIATFAGSSEAFVREGFNFIVGTDWNAVEGRESYGALPYIIGTLASSAIAMAIGVPISLGIAMFISDMAPRKLTAPLSFVIELLAAVPSIIYGLWALFVFRFWVRDLIELPLYNAFGGSIPLFARTPFGLDIFTAGIVLAVMIIPTVSSISREVMRAVPNSQREAAYSLGATRWETLRMAVFPYARSGLFGASILGLGRAVGETMLVTMVIGNAIGLAAIPNTLFSPSQTLASLIANEFNEAVTSFHTSALIGLGAVLFLLTIVINIGARLMVSRIQKIERVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIN4</accession>
    <name>K0IIN4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c28610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59780">
        <property type="protein sequence ID" value="AFU59780"/>
        <property type="gene ID" value="Ngar_c28610"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c28610"/>
    <dbReference type="HOGENOM" id="CLU_032903_4_6_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2861-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="113" mass="13688" checksum="00ACF47B26297233" modified="2012-11-28" version="1">MFCFTKDLQTYKFRLYPTEQQIKVMNETIEICRHLYNDSLGERSSNWSVGFYEQKQLLTLRRQDNKYYKQVHSQVLQDIVLRLDKAYQAFFKKYLGIQDSSEKRGTFFHIPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>K0IIW5</accession>
    <name>K0IIW5_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysX2</name>
        <name evidence="6" type="ordered locus">Ngar_c29970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ga9.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c29970"/>
    <dbReference type="EnsemblBacteria" id="AFU59915">
        <property type="protein sequence ID" value="AFU59915"/>
        <property type="gene ID" value="Ngar_c29970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c29970"/>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_2"/>
    <dbReference type="OMA" id="YEHKVFY"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="96"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFU59915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="287" mass="31803" checksum="9BE954F3E7ECAAF8" modified="2012-11-28" version="1">MVVELSIIYDKVRFEEKVLYEKAQSKGVKAQIVDAKTVTVSTDSKKKDFTFGDVIMQRSVSHYRGLYLTACLEHLGFNIINKFKVAETCGNKLITSLVLAENNIPTPRTQFAFSAEGALETIRKAGFPLVLKPIVGSWGRGVFPLRDEETAGMIVEMREEDDSPLARIYYVQEMIDRPPRDIRCIVVGNRVVTAIYRYSAENEFRTNVARGGKAELAPITKELEDLAIKAAKAVGGGILGVDMMEDKKRGLIVHEVNNTVEFHGAASVSKTDIPGAMIDYAVKLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJG3</accession>
    <name>K0IJG3_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c14710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU58407">
        <property type="protein sequence ID" value="AFU58407"/>
        <property type="gene ID" value="Ngar_c14710"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c14710"/>
    <dbReference type="HOGENOM" id="CLU_622046_0_0_2"/>
    <dbReference type="OMA" id="WLTHHIT"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-1469-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="1">
        <location>
            <begin position="241"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU58407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="440" mass="51347" checksum="04F7145B03C7577E" modified="2012-11-28" version="1">MKAMSAKTFLGSFTEPRELFLGSLENIADSTTKKLELKLYNLRNQKVVSSRHRFGGAAVSWSTWRQFNSAQKDPAKRKQVFDEFISKTKYLSPTIKARFDQMGKIYSEYSRKKLSPLDGYLENEKVSYSQLIDFVKSMGQQAKKPFQEALATISKKVLGRDAEYYDDFYFFRNRVYADLEKEFAGVNPPDQVRRTLAAMQFDLSPIHFDTEDRKNKYPSPICFFVQVPSDIRVLYKSESPYFDLQGCYHEMGHAMHASSISSRAKYWDRYGFSMGIAEVFSIFLERLTKNKKYLSSLGVHDERVLDEIEERNNFMELFFVTFYTANSLMKAEFWRKKLSMEKASDLYANLIKEYTGLEMPGEYWMLHHILPDAIMYVPSYLLAAVRAAELDHHLQGRFGEEWWTQTEAGSYIREITEPGAKIDLSRFSRLDSSLFMNEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>K0IJI4</accession>
    <name>K0IJI4_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c24190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59343">
        <property type="protein sequence ID" value="AFU59343"/>
        <property type="gene ID" value="Ngar_c24190"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c24190"/>
    <dbReference type="HOGENOM" id="CLU_3057252_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2417-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="53" mass="6177" checksum="1EDD491A2CE80710" modified="2012-11-28" version="1">MIPELVLVPNTTLVSPILAPVVPDHMLKVVPLVPKFLFWCQIWYHWYQANCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>K0IKE9</accession>
    <name>K0IKE9_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Ngar_c27970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59718">
        <property type="protein sequence ID" value="AFU59718"/>
        <property type="gene ID" value="Ngar_c27970"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c27970"/>
    <dbReference type="HOGENOM" id="CLU_1718275_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2797-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFU59718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="152" mass="16880" checksum="2FE1D4D997A78542" modified="2012-11-28" version="1">MEETKPSAADSIKAKPVEMVNISTTQPTTITNKIAKKKPLPLKKQIEYVKKNFESGDGYLVTIEAKRINQSQAILHGKVYQMKIGHDDRLAYEGTMTYTIKDPNFQDQEFVIAVNLGQESLMQRFEGMLKGNASNVMGTIVQIIGGIGFKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>K0IL37</accession>
    <name>K0IL37_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c32170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32170"/>
    <dbReference type="EnsemblBacteria" id="AFU60133">
        <property type="protein sequence ID" value="AFU60133"/>
        <property type="gene ID" value="Ngar_c32170"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32170"/>
    <dbReference type="HOGENOM" id="CLU_2340274_0_0_2"/>
    <dbReference type="OMA" id="DEQRCIG"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-3217-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="97" mass="10694" checksum="F200C511E41668D3" modified="2012-11-28" version="1">MPIAILPDVDEQRCIGCALCVEICTALGPDVLRVKPVEGWKRGKAFVFYPERCISDGACVGVCPTHAIFWMRPMEYTAGQPVPLHKNGVFSKGWEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>K0IMR2</accession>
    <name>K0IMR2_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisI</name>
        <name evidence="9" type="ordered locus">Ngar_c35940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c35940"/>
    <dbReference type="EnsemblBacteria" id="AFU60507">
        <property type="protein sequence ID" value="AFU60507"/>
        <property type="gene ID" value="Ngar_c35940"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c35940"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3602"/>
    <dbReference type="HOGENOM" id="CLU_048577_5_3_2"/>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU60507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="109" mass="12312" checksum="FE91AA1E1BE12649" modified="2012-11-28" version="1">MNAKSLKDIDFEKRNGLLPVIVQDRKTKDILMLAYANKEALANTAKTGNAWFWSTSRNKLWMKGEESGNVQPVHEILVDCDSDAILYMVDSDKPACHTGNRSCFHNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN69</accession>
    <name>K0IN69_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proline--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="6">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">proS</name>
        <name evidence="8" type="ordered locus">Ngar_c19220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="6"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19220"/>
    <dbReference type="EnsemblBacteria" id="AFU58854">
        <property type="protein sequence ID" value="AFU58854"/>
        <property type="gene ID" value="Ngar_c19220"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19220"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.1900"/>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_2"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="45"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFU58854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="489" mass="55432" checksum="42EC8EA4512FE25E" modified="2012-11-28" version="1">MSSGVSSQPRGEAAGITVKKSEDFSEWYTQVVLKAGLADYAPVKGFIVLRPYGYAIWESIRDILDRRFKETGHQNGFLPVLIPESLLSKEEDHFAGFTPEVFWVTKAGDNNIGEKLALRPTSETLAYSVFAKWITSYRDLPLKINFWNTALRAEIKATKPFIRTSEFLWQEGHTVHATEEEAEQEVMTILGIYKDMIENYLAVPVITGYKSDTEKFVGAKYTTTLEGLMADGKALQMGTSHHLAQNFSKPFEIKYLGKDTKEHFAWQTSWGVSWRLIGALIMVHGDDKGLVLPPQIAPIQVVIVPIHKDKDAKLVKDKAAEIELELKHAGIRAYMDSRDEYTSGWKFNEWEMKGVPLRINLGPRDIEKGQVEFVRRDTKDKKQDDRTKLVDTANSLLVEIQKNLLSKARAFLQENISRPASYDEFKSIIENKGGFVMVGWCGQEECEEKIKQDTGADIRVLPFDQKDRPGKCIYCGQDSKKAAIFARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>K0IN76</accession>
    <name>K0IN76_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">res</name>
        <name evidence="4" type="ordered locus">Ngar_c19570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU58889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c19570"/>
    <dbReference type="EnsemblBacteria" id="AFU58889">
        <property type="protein sequence ID" value="AFU58889"/>
        <property type="gene ID" value="Ngar_c19570"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c19570"/>
    <dbReference type="HOGENOM" id="CLU_540380_0_0_2"/>
    <dbReference type="OMA" id="NIGWLER"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="246"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU58889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="558" mass="63637" checksum="82FE710715EE6160" modified="2012-11-28" version="1">MTNAQEEKAGTTAPPSGATNAAEDAVASSSTIIRHEGQTVVKQRNVAEVKARADRPHFVYNRVYVGLAKGPCEEYSIDRDTSVLTRDSTVADFMKKPYALIPQAEGNTYLLVVPKWIDYKAGWLETQTETYNIYKVDHYATWAGLVPEELREELDLKPRFLTLKIQGDYLVGSEDELDDAWIRYRDSLLRREEGIGIRIKPSRASRFNLASRLVEDGVIPWTSKPVEQRWKWQTDIQLRPYQQEAFDFFLKNGAMTLVYPFGGGKSFFGVYVAACISGRTLVVVPSLSLISVWQKYIMEHFPDSGSRPSVGLFYGAKKEKHKDITIATYDSALAHLTKEKYELLIFDESHHFPAETYSRLAFLDARYRLSLSGSPHREDGRSELIYVLGGAPYGSDWERLFKEGWVKRPEVYLHVTSTKLMLLKSLLEEKLKGPTMVFCDTIAIGEDTSRITGLPYIHGRHSLKERSELVRKHPRFIASRIFDEGIDLPDIKNIIEIDFLGGSRRQQLQRVGRLMHSVLEGAEYHLLMSPEELAKYGKRLYGLYSRNFRVSVVTEQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>K0INJ1</accession>
    <name>K0INJ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Ngar_c25420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ga9.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c25420"/>
    <dbReference type="EnsemblBacteria" id="AFU59464">
        <property type="protein sequence ID" value="AFU59464"/>
        <property type="gene ID" value="Ngar_c25420"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c25420"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2519"/>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_2"/>
    <dbReference type="OMA" id="WDVIRCA"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2541-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="8">
        <location>
            <begin position="346"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFU59464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="458" mass="49604" checksum="5CE78FCA426E1908" modified="2012-11-28" version="1">MKGGKAKTVSATKYNSKADLARRVKSGEFKIAVYGLGHVGSPLASVWLRAGAYVIGVDKSPRVLENAKKGKTHVPEPGVNEAFSKGLKDKRFYVYDDPVKASQNAHFKLICVPVLLTDSFSADLAAVKQVASAIGRGLKKGDVVSLNPSVPPGTSEDVVLPILEKESGLQAEWDFYMVYNPERIYEGRAIEDIEERYPAVIAGAGPKSLEIGSKLYSLVAKKGVIKMSSMRTAETEKLLEGVYRDVNIALANEMAKFCEKVGVDFWEAREAANSQPFCHIHKPGAGVGGACIPVYPHFVLHTADINKVECNITRLGRNVNDSMPAYCVDQAMKLLEGASVSQSTVTLLGLAFRGSVSDTRLSPTYKIIEELKKLKVKEIRVHDPLVASDPALPQDVMLTSNLSKAVQGADLVMLVSDHPEYRSLTQRELGGAPVYDGRGILDGSRFASGRFAAIGKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>K0INK8</accession>
    <name>K0INK8_NITGG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Ngar_c26270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ga9.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFU59549">
        <property type="protein sequence ID" value="AFU59549"/>
        <property type="gene ID" value="Ngar_c26270"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26270"/>
    <dbReference type="HOGENOM" id="CLU_2392989_0_0_2"/>
    <dbReference type="BioCyc" id="CNIT1237085:G1324-2627-MON"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFU59549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="93" mass="10465" checksum="D64812A332DE5344" modified="2012-11-28" version="1">MCGKNLFLLENLWFQMQLKSWMAIAGLVAVGSVLTGLLYFQPQLFDNIIAAKEPFIAITIEGLKDTYKVGEPIDFIVRIEGHGCDRASFNRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>K0INM0</accession>
    <name>K0INM0_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">eIF-5A</name>
        <name evidence="11" type="synonym">eif5a</name>
        <name evidence="13" type="ordered locus">Ngar_c26880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU59609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c26880"/>
    <dbReference type="EnsemblBacteria" id="AFU59609">
        <property type="protein sequence ID" value="AFU59609"/>
        <property type="gene ID" value="Ngar_c26880"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c26880"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.2663"/>
    <dbReference type="HOGENOM" id="CLU_102600_3_0_2"/>
    <dbReference type="OMA" id="QIMDMET"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="PTHR11673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF-5a" evidence="12">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFU59609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="134" mass="14852" checksum="E427626DFBC9D3FC" modified="2012-11-28" version="1">MSKPMDLGALKVGSYIIIDGEPCRIVSYDHSKPGKHGSAKARITAVGVFDGRPHPFVGPVSTKVDVPLIDKRNGQIISKQGDTLQIMDLETFETFETSSVEDEIKEKLAQGDIQGREVEYWKVLDRIKIVRVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>K0INZ1</accession>
    <name>K0INZ1_NITGG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="2">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="2">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">msrA</name>
        <name evidence="4" type="ordered locus">Ngar_c32990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Nitrososphaera gargensis (strain Ga9.2)</name>
        <dbReference type="NCBI Taxonomy" id="1237085"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Thaumarchaeota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Environ. Microbiol." volume="14" first="3122" last="45">
            <title>The genome of the ammonia-oxidizing Candidatus Nitrososphaera gargensis: insights into metabolic versatility and environmental adaptations.</title>
            <authorList>
                <person name="Spang A."/>
                <person name="Poehlein A."/>
                <person name="Offre P."/>
                <person name="Zumbragel S."/>
                <person name="Haider S."/>
                <person name="Rychlik N."/>
                <person name="Nowka B."/>
                <person name="Schmeisser C."/>
                <person name="Lebedeva E.V."/>
                <person name="Rattei T."/>
                <person name="Bohm C."/>
                <person name="Schmid M."/>
                <person name="Galushko A."/>
                <person name="Hatzenpichler R."/>
                <person name="Weinmaier T."/>
                <person name="Daniel R."/>
                <person name="Schleper C."/>
                <person name="Spieck E."/>
                <person name="Streit W."/>
                <person name="Wagner M."/>
            </authorList>
            <dbReference type="PubMed" id="23057602"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2012.02893.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ga9.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CP002408">
        <property type="protein sequence ID" value="AFU60214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1237085.Ngar_c32990"/>
    <dbReference type="EnsemblBacteria" id="AFU60214">
        <property type="protein sequence ID" value="AFU60214"/>
        <property type="gene ID" value="Ngar_c32990"/>
    </dbReference>
    <dbReference type="KEGG" id="nga:Ngar_c32990"/>
    <dbReference type="PATRIC" id="fig|1237085.11.peg.3290"/>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_2"/>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="Proteomes" id="UP000008037">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="3">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFU60214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008037"/>
        </source>
    </evidence>
    <sequence length="184" mass="21189" checksum="C3AC6E64C6C31CB0" modified="2012-11-28" version="1">MKENNIEVATLANGCFWCSEAIFTRLKGVKSVVPGYSGGLIENPTYDEVCTGTTGHAEAAQIEFDPSIISFEKLLDVFWHTHDPTTLNRQGADVGTQYRSVIFYHNEKQREIAERSKMELEKSGIYKDPIVTEITPFKKFYLAEDYHKKYYESHKSAPYCRFVIEPKIHKLLNKYGKDIKSEYS</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>